Matlapa a Symlo 5 mg: litaelo le litlhahlobo tsa lithethefatsi

Sebopeho Simlo

• Matlapa a koahetsoeng a SIMLO

Ba hlahisang: starch ea poone, lactose, cellcrystalline cellulose, sodium starch glycolate, starch ea gelatinized, oxide ea tšepe, isopropanol, hydroxytoluene butylate, metsi a hloekisitsoeng, citric acid monohydrate, talc e hloekisitsoeng, magnesium stearate, hydroxyphenyl methylene dichlorhen.

Li-pcs tse 10 - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
14 li-PC. - Mabokose (2) - lipakete tsa karete.
14 li-PC. - lithutsoana (3) - lipakete tsa karete.

Lintho tse tsoang ho bona: starch ea poone, lactose, cellcrystalline cellulose, sodium starch glycolate, statin e tsoang ka lehare, oxide e khubelu ea tšepe, isopropanol, hydroxytoluene butylate, metsi a hloekisitsoeng, citric acid monohydrate, talc e hloekisitsoeng, magnesium stearate, hydroxyphenylmethylene methylypyleneyleyleyleylene methylpylstylene.

Li-pcs tse 10 - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
14 li-PC. - Mabokose (2) - lipakete tsa karete.
14 li-PC. - lithutsoana (3) - lipakete tsa karete.

Lintho tse tsoang ho bona: starch ea poone, lactose, cellcrystalline cellulose, sodium starch glycolate, statin e tsoang ka lehare, oxide e khubelu ea tšepe, isopropanol, hydroxytoluene butylate, metsi a hloekisitsoeng, citric acid monohydrate, talc e hloekisitsoeng, magnesium stearate, hydroxyphenylmethylene methylypyleneyleyleyleylene methylpylstylene.

Li-pcs tse 10 - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
14 li-PC. - Mabokose (2) - lipakete tsa karete.
14 li-PC. - lithutsoana (3) - lipakete tsa karete.

• Matlapa a koahetsoeng a SIMLO

tab. sheath, 5 mg: 20, 28, 30 kapa 42 li-PC.

• Matlapa a koahetsoeng a SIMLO

tab. sheath, 10 mg: 20, 28, 30 kapa 42 li-PC.

• Matlapa a koahetsoeng a SIMLO

tab. sheath, 20 mg: 20, 28, 30 kapa 42 li-pcs.

Contraindication Simlo

• Tafole tse kopaneng tsa SIMLO

- lefu la sebete le matla,

- lefu le sa foleng la sebete sehlopheng se hlobaetsang,

- keketseho e phehellang ts'ebetsong ea li-transaminase tsa tlhaho e sa tsejoeng,

- ho anyesa (matsoele),

- bana le bacha ba ka tlase ho lilemo tse 17,

- Hypersensitivity ho simvastatin le likarolo tse ling tsa lithethefatsi,

- Hypersensitivity ho li-inhibitors tse ling tsa HMG-CoA reductase.

Tekanyetso le tsamaiso ea Simlo

• Tafole tse kopaneng tsa SIMLO

Mokhoa oa kalafo ea litekanyetso le nako ea kalafo li beoa ka bonngoe.

Ho latela boholo ba hypercholesterolemia, lethal dose la pele ke 5 mg / letsatsi. Ka hypercholesterolemia e matla - 10 mg 1 nako / letsatsi. Haeba ho hlokahala, eketsa lethalfu le nang le nako ea libeke tse 4. Tekanyo e phahameng ea letsatsi le letsatsi ke 40 mg.

Moriana o lokela ho nooa 1 nako / letsatsi ka shoalane, pele kapa nakong ea lijo.

Bakeng sa bakuli ba fumanang li-immunosuppressants, litekanyetso tsa ho qala tse khothalelitsoeng ke 5 mg / ka letsatsi, tekanyetso e kholo ea letsatsi le letsatsi ke 5 mg / ka letsatsi.

Bakuli ba nang le bofokoli bo fokolang ba 'mele kapa bo itekanetseng ha ba hloke ho lokisa mofuta oa kalafo. Bakeng sa bakuli ba nang le ho se sebetse hantle haholo ha renal, lethal dose la pele ke 5 mg / letsatsi, athe sehlopha sena sa bakuli se hloka ho hlahlojoa khafetsa kalafo.

Litla-morao tsa Simlo

• Matlapa a koahetsoeng a SIMLO

Ho tsoa ho tsamaiso ea tšilo ea lijo: hangata - ho sokela, letšollo, ho felloa ke takatso ea lijo, ho ruruha, ho nyekeloa ke pelo, bohloko ba ka mpeng, pancreatitis, mohlomong keketseho e phehellang ea lipalo tsa li-transaminase le CPK maling a mali (hangata hangata qetellong ea khoeli ea pele ea kalafo). Kamora nako e pakeng tsa beke ea bobeli le ea 4 ho tloha ha ho qala kalafo, ho ka ba le keketseho ea lipalo tsa mali tsa ALT, AST le alkaline phosphatase. Keketseho e phahameng ea lipontšo tsena e bonoa ho pota beke ea borobeli ea 8 ea kalafo. Kamora ho khaotsa kalafo ea lithethefatsi, maemo a enzyme a fokotsoa ho maemo a tloaelehileng.

Karolong ea methapo ea pelo le methapo ea pelo: methapo ea methapo ea kutlo e ka etsahala (ho etsahala hangata haholo ha ho nooa moriana ka tekanyo ea 10 mg / ka letsatsi, ho nka nako butle ka tlhaho mme ha ho hloke tokiso ea moriana oa litekanyetso).

Ho tsoa ho tsamaiso ea methapo e bohareng le tsamaiso ea methapo ea methapo: hlooho ea hlooho, likhathatso tsa boroko, asthenia, ho tsekela ho ka etsahala.

Ho tsoa ho tsamaiso ea musculoskeletal: ka seoelo - myopathy, rhabdomyolysis.

Ho tsoa ho sistimi ea hemopoietic: ka seoelo - eosinophilia, thrombocytopenia.

Litla-morao: Ha ho na nako - urticaria, angioedema.

Tse ling: ka seoelo - photosensitization, vasculitis, lefu la lupus-like.

Ka tloaelo lithethefatsi li mamelloa hantle. Litla-morao hangata li ba bonolo ebile li ba bonolo.

• Matlapa a koahetsoeng a SIMLO

Lintlha tse mabapi le overdose ea lithethefatsi Simlo ha e fanoe.

• Matlapa a koahetsoeng a SIMLO

Ka tšebeliso e tšoanang ea Simlo e nang le li-immunosuppressants (cyclosporine), erythromycin, gemfibrozil, nicotinic acid, kotsi ea rhabdomyolysis le ho hloleha ho hlobaetsang le leqeba ho eketseha.

Ka tšebeliso e tšoanang ea Simlo e nang le li-anticoagulants tse sa tobang, keketseho ea ts'ebetso ea pharmacological ea ho qetela e ka etsahala.

Ka tšebeliso e tšoanang ea Simlo e nang le colestyramine, bioavailability ea simvastatin ea fokotseha (ho kgothaletsoa ho nka Simlo lihora tse 4 kamora ho nka colestyramine).

Ka tšebeliso ea nako e le 'ngoe ea Simlo le digoxin, keketseho ea khatello ea ho qetela ea plasma e etsahala.

• Matlapa a koahetsoeng a SIMLO

Ka tlhokomeliso e fetelletseng, moriana o lokela ho fuoa bakuli ba sebelisang joala hampe le / kapa ba nang le nalane ea mafu a sebete.

Ka tlhokomeliso, lithethefatsi li lokela ho fuoa bakuli kamora ho fetisoa ha litho ho amohela li-immunosuppressants, ka lebaka la kotsi e eketsehang ea rhabdomyolysis le nts'etsopele ea ho se sebetse hantle ha renal.

Ka arterial hypotension, mafu a tšoaetsanoang a hlobaetsang, a nang le mathata a tebileng a metabolic, tsamaiso ea endocrine, tekanyo ea motlakase oa metsi, nakong ea ts'ebetso ea ho buoa (ho kenyeletsa le meno) kapa likotsi, ho bakuli ba nang le tonus ea lesapo la methapo ea etiology e sa tsejoeng, e nang le lefu la sethoathoa, moriana o laetsoe ka hloko, hobane mafu le maemo a thathamisitsoeng a ka lebisa ho se sebetse hantle haholo ha renal.

Tlhokomelo ea laboratori

Nakong ea ts'ebeliso ea lithethefatsi, hoa hlokahala ho laola se ka har'a k'holeseterole ea plasma. Boithuto ba pele bo etsoa libeke tse 4 kamora ho qaleha ha moriana, ebe ho etsoa tlhahlobo e hlophisehileng ea letšoao lena kamehla.

Pele le nakong ea kalafo le lithethefatsi, litaba tsa li-enzyme tsa sebete ka serum li lokela ho hlahlojoa: nakong ea likhoeli tsa 3 tsa kalafo, tlhahlobo e etsoa ka nako ea libeke tse 6, ebe kamora likhoeli tse ling le tse ling tse 6. Ka keketseho ea litekanyetso tsa serum transaminase ka makhetlo a fetang a 3 ha ho bapisoa le maemo a motheo, kalafo e nang le Simlo e lokela ho emisoa.

Nakong ea ts'ebeliso ea lithethefatsi, ho hlokahala ho laola boemo ba CPK ho bakuli ba fumanang li-immunosuppressants kapa nicotinic acid, le myopathy (myalgia, bofokoli ba mesifa). Ka keketseho ea boemo ba CPK ka makhetlo a fetang 10 ha ho bapisoa le litekanyetso tse tloaelehileng, moriana o lokela ho emisoa.

• Tafole tse kopaneng tsa SIMLO

Setlhare se lokela ho bolokoa ka se omileng, se sirelelitsoeng ke bobebe, hole le bana ka mocheso o sa feteng 25 ° C.

Bophelo ba Shelf ke lilemo tse 2. Setlhare ha sea lokela ho sebelisoa kamora letsatsi la ho felloa ke nako le bonts'itsoeng sephutheloaneng.

Sebopeho sa moriana

Letlapa le leng le le leng la Simlo le kopantsoe le koae e le 'ngoe,' me e na le mofuta o latelang:

Motsoako o sebetsang: simvastatin 10,000 mg

• Lactose monohydrate ka bongata ba 75 500 mg,
• Cricric monohydrate eseng ho feta 1,250 mg,
• Ascorbic acid 2 500 mg,
• Cellulose e boima ba 9,400 mg,
• Magnesium stearate 1,200 mg.

Khetla ena e na le: hypromellose, tolk, titanium dioxide 0.520 mg, dae ea tšepe e putsoa 0,002 mg, macrogol-400 0.120 mg., Iron oxide red oxide 0.038 mg.

Letlapa le leng le le leng la Simlo 20 mg le nang le koae ea lifilimi le na le:

Motsoako o sebetsang: motsoako simvastatin 20,000 mg.

• 151,000 mg lactose monohydrate,
• 2 500 mg ea pregelatinized starch,
• Silicon diabetes colloidal 2,400 mg,
• Sodium carboxymethyl starch (mofuta A) 15,000 mg,
• Butylhydroxytoluene 04040 mg,
• Cricric monohydrate 2,5 mg,
• Khoele e khoele ka boima bo sa feteng 20,360 mg,
• 5,000 mg ascorbic asiti,
• Microcrystalline cellulose ka bongata ba 18,800 mg,
• ntho ea magnesium stearate ha e fetang 2,400 mg.

Khetla ea khalase e na le: talcum boima 1,040 mg, hypromellose e boholo ba 2,400 mg, titanium dioxide e boima ba 1,040 mg, dae oxide 0,036 mg, macrogol-400 0,240 mg, tšepe oxide dae 0,044 mg.

Simlo e bontšoa hore e ka sebelisoa maemong a itseng:

1. Ka hyperlipidemia, maemong a ha kalafo ea ho ja ka k'holeseterole e tlase le mehato e meng eo e seng ea meriana e sa sebetse.
2. Sebakeng sa ho hlaha ha hypercholesterolemia e kopaneng, hypertriglyceridemia le hyperlipoproteinemia, e ke keng ea lokisoa ke lijo tse khethehileng kapa mojaro.
3. Ha homozygous lefutso la hypercholesterolemia le hlaha.
4. Ha lefu la pelo le matla la coronary le hlaha (joalo ka thibelo ea bobeli).
5. Ha e khothalletsoa hore e sebelisoe ke bakuli ba hlokang ho fokotsa lefu.
6. Ho fokotsa kotsi ea infaration ea myocardial.
7. Haeba ho hlokahala, fokotsa kotsi ea ho shoa ha coronary.

Foromo le sebopeho sa litekanyetso

Simlo ke mofuta oa litekanyetso o nang le phello ea ho fokotsa lipid. Mochine oa phekolo ke tšitiso ea ts'ebetso ea enzymatic ea HMG-CoA reductase.

Sokolla foromo Simlo - likhabapo le litafole, filimi-e koahetsoeng ka holimo. Mmarakeng oa rona oa litheko ho na le mefuta e meraro ea litekanyetso - 5, 10 le 20 mg.

Ntho e sebetsang - simvastatin (simvastatin - ho ea ka radar - ts'ebeliso ea lithethefatsi). Lintho tse ling tse hlahisang letlapa: starch ea poone, ferrum oxide, 4-valent titanium oxide, microcrystalline le hydroxypropylmethyl cellulose, isopropanol, methylene chloride, citric acid monohydrate.

Litlamorao tsa ts'ebeliso ea meriana ea simvastatin ena li amahanngoa le bokhoni ba eona ba ho thibela tlhahiso ea cholesterol ea pele ke 'mele. Ka hona, kamora ts'ebeliso ea eona, ho na le phokotso ea likarolo tsa mafura maling. Haholo-holo, khatello ea li-triglycerides, LDL le VLDL, cholesterol e felletseng ea fokotseha, tekanyo ea lipoprotein ho e mong le e mong ea ntlafala, mme karolelano ea cholesterol e felletseng ka likarolo tsa eona (litaba tsa cholesterol le HDL li tsitsitse ka mokhoa o itekanetseng).

Phello ea kalafo e etsahala libeke tse peli kamora ho qala ho nka Simlo. Tlhako ea phello ea kalafo e etsahala nakong ea beke ea bone ho isa ho ea botšelela ea tšebeliso ea statin. Ho feta moo, ts'usumetso ena e sala e le nakong ea kalafo, leha ho le joalo, ha phekolo e felisitsoe, palo ea tekano ea lipid e tla khutlela boemong ba pele pele ho kalafo ea lithethefatsi.

Litšobotsi tsa Pharmacokinetic li kenyelletsa ho monya mucous ea mucosa ka potlako haholo. Biotransformation le metabolism ea simlo e hlaha ho sebete. Li-metabolites tse sebetsang li thehoa moo, e leng beta-hydroxymetabolites. Ho fihla ho 95% ea bona ba tlama ho haha ​​liprotheine tsa mali.

Mekhoa e meholo ea excretion ea ntho e setseng ea lithethefatsi e teng ka bile le liphio. Ke ka lebaka leo, symlo e sa fuoeng mafu a liphio le sebete sethaleng sa liponahatso tse mpe. Nakong ea ts'ebeliso ea simvastatin, li-transaminase tsa plasma le CPK li lokela ho betoa leihlo khafetsa.

Bakeng sa enzymes ea hepatic plasma, thuto ea pele e lokela ho etsoa libeke tse tšeletseng kamora ho qala kalafo.

Litlamorao

Maemong a sa tloaelehang, 'mele oa mokuli o ka fana ka likarabo tse' maloa mabapi le tšebeliso ea symlo. Liponahatso tse latelang li hlahisitsoe ke motsoako ona oa matšoao:

1. Ho ba le takatso ea takatso ea lijo, nts'etsopele ea letšollo le ho sokela, tse tla tsamaeang le liketsahalo tsa ho nyekeloa, pelo, le bohloko ba ka mpeng.
2. Arterial hypotension e ka etsahala - boemo boo khatello ea mali e fokotsehang ka tlase ho lipalo tse tloaelehileng, mathata a metabolic.
3. Cephalgia, mathata a potoloho ea neurogenic.
4. Ho senyeha ha mesifa - joalo ka myopathy, bohloko mokokotlong, maemong a matla - rhabdomyolysis e tsoang mochining oa moroto o nang le ts'oaetso e matla ea renal.
5. Boitšoaro ba Hypersensitivity le mekhoa e meng ea autoimmune - vasculitis, allergic edema, syndrome ea lupus-like.
6. Letlalo la letlalo, bofubelu bo hlakileng, ho hlohlona.
7. Lithutong tsa laboratori tse tsoang tsamaisong ea hematopoietic, ho ke ke ha khonahala ho kheloha tataiso ea setšoantšo sa lefu la anemic le eosinophilia.

Haeba u na le letšoao le le leng kapa a mangata a thathamisitsoeng ka holimo, o lokela ho ikopanya le ngaka hang-hang, 'me haeba ho hlokahala, fokotsa tekanyetso ea moriana, kapa o khaotse ho o sebelisa.

Ho sebelisana le lithethefatsi tse ling

Simlo e lokela ho kopanngoa le ho ba hlokolosi le lithethefatsi tse kang fibrate (gemfibrozil), cyclosporine, niacin, erythromycin le lingoloa tse 'maloa tsa bona. Ha e sebelisoa hammoho le bona, bioavailability ea lithethefatsi e eketseha, mahloriso a bona a plasma a eketseha, menyetla ea rhabdomyolysis e tsoela pele makhetlo a 'maloa, e lateloe ke ho se sebetse hantle ha renal, mme haholoholo ka lebaka la khatello ea methapo.

Ha e kopantsoe le li-anticoagulants, li-simvastatin li ka ntlafatsa katleho ea tsona. Ho lebisoa tlhokomelo e khethehileng ho bakuli ba nang le ho nyekeloa ke pelo ba fumanang kalafo ka pelo le pelo - digoxin. Simvastatin e eketsa haholo khatello ea eona ho plasma, eo, ha e fuoa bokhoni ba glycoside, e ka fanang ka mathata a tebileng ho tsamaiso ea pelo le pelo, e mpefatsang lefu la pelo.

Analogs Simlo

Marakeng oa rona oa meriana, Simlo statin e na le li-analogu tse 'maloa. Tsena li kenyelletsa sebaka sa ntho e sebetsang - Simvakard 10, 20, 40 mg, Simgal 10, 20 le 40 mg, Vasilip 10, 20 le 40 mg.

Mananeo a tlase le ona a fanoa. ho latela molao-motheo oa ketso. Mona, mola oa lithethefatsi tsa mantlha le li-generics ha o na moeli - ho tloha Atorvastatin, Torvakard, Atoris, Liprimar, Krestor, ho ea Holletar, Lipostat, Livazo le Rosucard. Tsena kaofela li na le litlamorao tse fokolisang lipid mme ke tsa sehlopha se seholo sa lithethefatsi - li-statins.

Tlhahlobo

Viktorova S.N., Moscow, ngaka ea sehlopha se phahameng ka ho fetisisa, hlooho ea lefapha la endocrinology Sepetlele sa Clinical City No. 7: Ke qetile lilemo tse ngata ke khetha Simlo bakeng sa bakuli ba ka. Ha e khotsofetse ke liphetho, moriana o paka ts'ebetso ea ona le ts'ebetso ea ona liprothong tsa bongaka. Ha e le statin, litla-morao tsa eona ha li fumanehe ka mokhoa o khahlisang; kalafo ea bakuli bohle e mamelloa hantle. Kamora kalafo ea lithethefatsi, lipid tsa mali li lula li tsitsa. ”

Pavelko P.A. Kiev, ea lilemo li 65, ea penshene: “Hoo e ka bang lilemo tse 'ne tse fetileng, ngaka e ile ea mpolella Simlo, hobane ho na le lintho tse ngata tse ileng tsa kheloha ponong ea lipid. Ho fihlela moo nke keng ka bua ka 'nete, ke hopola hore ho ne ho na le cholesterol e phahameng le triglycerides, hoo e ka bang tlhahlobo eohle e ile ea phahamisoa. Hona joale letsatsi le leng le le leng ke nka pilisi le taelo ea bophelo bo botle. Ntho feela e ferekanyang ke hore hona joale bophelo bohle ba ka ke tla tlameha ho lula litafoleng. Ngaka e ile ea re kamora ho emisa kalafo ka moriana, mabele ohle a methapo ea mali a ka khutla, ka hona ke hloka ho a sebelisa khafetsa. ”

Litlhahlobo mabapi le Simlo ho tsoa ho lingaka le bakuli li ntle maemong a mangata. Sena se bakoa ke keketseho e ntle ea theko / boleng, e nang le boiphihlelo bo bolelele, 'me ka ho fetisisa, bo atlehileng tšebelisong ea lithethefatsi tsa bongaka. Ke inhibitor e sebetsang e netefalitsoeng ea HMG-CoA reductase, e na le boteng bo atileng liketaneng tsa litlama 'me hangata ha e hlahise litlamorao.

Litaelo tsa sethethefatsi sena

Sephutheloana se seng le se seng sa lithethefatsi Simlo e kenyelletsa litaelo tsa ho amoheloa.

Litaelo tsa moriana li na le tlhahisoleseling mabapi le matšoao, litekanyetso tse hlokahalang, litla-morao, li-contraindication, mofuta oa tokollo, sebopeho, liketso tsa bongoallo, mokhoa oa tsamaiso, maemo a kamohelo nakong ea kemaro kapa ea matsoele, maemo a polokelo, le bophelo ba sefuba.

Ntle le moo, ho boetse ho na le data ka theko le analogues.

Thutela-litso

Simlo ea lithethefatsi e etselitsoe ho etsa hore likarolo tse ngata tsa mali li fetohe. Molao-motheo oa phello ea lithethefatsi Simlo o thehiloe ho bokhoni ba eona ba mantlha ba ho hatella lits'ebetso tsa e mong oa li-cholesterol tse tlang pele ho sebete.

Tsamaiso e tloaelehileng ea sebopeho sa biochemical ke e 'ngoe ea lintlha tsa bohlokoa tse fokotsang tsoelo-pele ea atherosclerosis, e fokotsang monyetla oa ho ba le lefu la ischemic, hape ke tšireletso e ntle ea ponahalo ea infraction ea myocardial.

Ha a nooa, lithethefatsi li qala ho bapisoa ka mpeng e nyane. Re lokela ho hlokomela hore methati ea pele ea ho belisoa ha ntho e sebetsang e etsahala marapong a mala. Ha o feta ka har'a sebete, boholo ba lintho bo fetoloa hore e be tse tsoang ho eona.

Matšoao a ho amoheloa

Sethethefatsi se khothalletsoa hore se sebelisoe:

1. Hyperlipidemia (e ka fuoa feela maemong a kalafo e sa sebetseng ea phepo le mehato e meng eo e seng ea lithethefatsi.
2. Lefu la pelo (le thibelo ea bobeli).
3. Le mofuta oa phekolo o kopantseng oa hypercholesterolemia le hypertriglyceridemia.
4. Hyperlipoproteinemia, e ke keng ea lokisoa ke lijo, hammoho le boikoetliso ba 'mele.
5. Ho fokotsa kotsi ea ho ba le lefu la coronary, hammoho le thibelo ea infyo ea myocardial.
6. Ho tšoenyeha ho potoloha ha boko.
7. Atherosclerosis

Ho amoheloa ha chelete

Hlokomela! Haeba ho hlokahala, ngaka e ka fetola litekanyetso.

Ka hypercholesterolemia, litekanyetso tsa pele ha ea lokela ho feta 5 mg / ka letsatsi. Ka ho tlola ka matla k'holeseterole maling, ho na le litlhare tse lekantsoeng ea 10 mg.

Moriana ha oa lokela ho fuoa mokuli nako e fetang hanngoe ka letsatsi. Haeba ho hlokahala, eketsa litekanyetso ka nako ea libeke tse 'ne. Tekanyetso e kholo e lumelletsoeng e ka nkuoang ka letsatsi ke 40 mg. Sesebelisoa se lumelloa ho nkuoa mantsiboea.

Tabeng ena, moriana o ka nooa o ntse o ja kapa o le ka pel'a oona. Bakeng sa bakuli ba fumanang li-immunosuppressants, litekanyetso li khothalelitsoe ke li-mg tse hlano ka letsatsi.

Bakuli ba nang le ts'enyo e bonolo ea letsoana kapa e leka-lekaneng, ha ho hlokahale phetoho ea litekanyetso.

Haeba lesion e tebile, joale litekanyetso tsa pele ha ea lokela ho feta 5 mg ka letsatsi. Maemong ana, ho bohlokoa haholo ho etsa tlhahlobo ea bongaka khafetsa.

Ka tšenyo e fokolang ea tšenyo ea sebete, ho lokisoa ha litekanyetso le hona ha ho hlokahale. Haeba tlhaselo e le matla, Simlo o lokela ho hana ho nka moriana.

Bakeng sa kalafo ea IHD, sethethefatsi se laetsoe ka tekanyetso ea 10 mg. Phallo ea ho amoheloa ka letsatsi ha ea lokela ho feta nako e le 'ngoe. Tekanyetso e phahameng e lumelletsoeng e lokela ho ba 10 mg.

Motsoako oa chelete le lithethefatsi tse ling

Ka tsamaiso e tšoanang ea Simplo e nang le cyclosporine, gemfibrozil, erythromycin kapa nicotinic acid, kotsi ea rhabdomyolysis e eketseha makhetlo a 'maloa.

Ha e tsamaisoa hammoho le li-anticoagulants tse sa tobang, phello ea morao e ka eketseha.

Ha e nkiloe ka cholesterol, bioavailability ea simvastatin e fokotseha. Haeba ho hlokahala hore ho sebelisoe lithethefatsi tse peli, Simlo e lokela ho nkuoa lihora tse 4 kamora ho nka cholestyramine.

Lithethefatsi Simlo makhetlo a 'maloa e eketsa khatello ea "digoxin" maling a motho.

Litlamorao

Ka linako tse ling 'mele o amehileng o ka arabela, o ka iponahatsang ho mokuli ka mokhoa oa matšoao a kang:

1. Letšollo, ho ruruha, ho fokotseha kapa takatso e matla ea lijo, ho nyekeloa ke pelo, ho ruruha, pancreatitis, bohloko ka mpeng.
2. Hypotension.
3. Bohloko bo bohloko hloohong, peripheral neuropathy, paresthesia.
4. Myopathy, myalgia, rhabdomyolysis.
5. Lupus-syndrome, lefu le eosinophilia, ho hema hanyane, vasculitis, angioedema, thrombocytopenia, feberu, ramatiki, urticaria.
6. Letlalong la letlalo, ho fifala ha letlalo, ho hlohlona, ​​alopecia, photosensitivity.
7. Boloetse

Haeba matšoao ana a qala ho bonahala, tsebisa ngaka hang-hang.

Nakong ea kemolo

Setlhare sena ha sea lokela ho nkuoa nakong ea kemolo kapa sefuba, joalo ka litlamorao tse ke keng tsa lokisoa li ka qala ho hlaha ho lesea.

Setlhare se tlameha ho beoa sebakeng seo mocheso o ke keng oa feta likhato tse 25.

Kamore ena e lokela ho futhumala ka ho lekaneng, e pholile, hape e lefifi. Setlhare se lokela ho bolokoa hole le bana le liphoofolo tse ratoang.

Ho latela litlhahiso tsohle, sehlahisoa se ka sebelisoa lilemo tse peli.

Sesebelisoa se felisitsoeng ha se lumelloe ho nkoa, hobane sesebelisoa se joalo se tla lematsa 'mele oa hau o seng o ntse o amehile.

Ho latela sebaka, litšenyehelo li ka fapana haholo.

Russia theko e tsoa ho li-ruble tse 275 ho isa ho 390.

Ukraine theko e ne e behiloe ho 198, 57 hryvnia.

Har'a litlhaloso tsa sesebelisoa sena, hoa khoneha ho khetholla lithethefatsi tse kang Vazilip, Zovatin, Zokor, Levomir, Ovenkor, Simvakol, Simvastol, Simvagestal, Holvasim, Simplakor, Simvakard, Holvasim, Simvor, Sinkard, Simplakor, Simgal, hammoho le mekhoa e meng.

Ha ho fanoa ka analogue, ngaka e lokela ho nahanela bokhoni ba lichelete ba mokuli, boemo ba hae bo akaretsang, hammoho le ho se utloane ka likarolo.

Har'a melemo, lenane le pharalletseng la li-analogues le ka khetholloa. Ntle le moo, ba bangata ba boetse ba khetholla mofuta o bonolo oa tsamaiso, hammoho le litšenyehelo tse tlase.

Ka ho fokotseha, bakuli ba kenyelletsa ho ba teng ha contraindication le litla-morao.

Litlamorao

Ho tsoa ho tsamaiso ea tšilo ea lijo: dyspepsia (ho nyekeloa, ho hlatsa, gastralgia, bohloko ba ka mpeng, ho sokela kapa ho ts'oaroa ke lefutso, hepatitis, jaundice, ts'ebetso e eketsehileng ea "transaminase" ea "sebete" le "alkaline" phosphatase, CPK, ka seoelo - pancreatitis e hlobaetsang.

Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa methapo ea kutlo: asthenia, chizungu, hlooho ea hlooho, ho hloka boroko, ho tsitsipana, paresthesia, peripheral neuropathy, pono e fifalitsoeng, tatso e sa sebetseng.

Ho tsoa ts'ebetsong ea musculoskeletal: myopathy, myalgia, myasthenia gravis, ka seoelo rhabdomyolysis.

Litla-morao le mathata a amanang le immunopathological: angioedema, lupus-like syndrome, polymyalgia rheumatism, vasculitis, thrombocytopenia, eosinophilia, ESR, ramatiki, arthralgia, urticaria, photosensitivity, feberu, hyperemia ea letlalo.

Boitšoaro ba letlalo: Rash letlalo, ho hlohlona, ​​alopecia.

Tse ling: phokolo ea mali, palpitations, ho hloleha ha renal haholo (ka lebaka la rhabdomyolysis), ho fokotseha ha potency.

Litaelo tse khethehileng

Pele o qala kalafo, ho a hlokahala hore a etse tlhahlobo ea ts'ebetso ea sebete (ho lekola tšebetso ea "sebete" transaminases libeke tse ling le tse ling tse 6 bakeng sa likhoeli tse 3 tsa pele, ebe libeke tse ling le tse ling tse 8 bakeng sa selemo sa pele se tlang ebe hang kamora likhoeli tse ling le tse ling tse tšeletseng). Bakeng sa bakuli ba fumanang simvastatin ka tekanyetso ea letsatsi le letsatsi ea 80 mg, ts'ebetso ea sebete e hlahlojoa hang ka likhoeli tse tharo. Maemong moo tšebetso ea "sebete" transaminase e eketsehang (e fetang makhetlo a 3 tekanyetso e kaholimo), kalafo e felisitsoe.

Ho bakuli ba nang le myalgia, myasthenia gravis le / kapa ka keketseho e tšoaeang ea ts'ebetso ea CPK, kalafo ea lithethefatsi e emisoa.

Simvastatin (hammoho le li-inhibitors tse ling tsa HMG-CoA reductase) ha ea lokela ho sebelisoa ka kotsi e eketsehang ea rhabdomyolysis le ho se sebetse hantle ha mali (ka lebaka la ts'oaetso e matla ea methapo, hypotension ea methapo, ts'ebetso e kholo ea mokokotlo, khatello ea maikutlo le mathata a tebileng a metabolic).

Ho hlakoloa ha lithethefatsi tse fokotsang lipid nakong ea kemolo ha ho ame litlamorao tsa kalafo ea nako e telele ea hypercholesterolemia ea mantlha.

Ka lebaka la hore HMG-CoA reductase inhibitor inhibit cholesterol synthetic, le cholesterol le lihlahisoa tse ling tsa motsoako oa eona li bapala karolo ea bohlokoa ntlafatsong ea ngoana, ho kenyelletsa motsoako oa li-steroid le membrane ea sele, simvastatin e kanna ea ba le phello e mpe ho lesea ha le laeloa basali ba baimana ( basali ba lilemo tsa ho ba le bana ba lokela ho latela mehato ea ho thibela pelehi ka hloko). Haeba ho ima ho etsahala nakong ea kalafo, moriana o lokela ho emisoa, mme mosali a lemose ka kotsi e ka bang teng ho lesea.

Simvastatin ha e bontšoe maemong ao ho nang le mofuta oa I, IV, le V hypertriglyceridemia.

E sebetsa ka bobeli ka mokhoa oa monotherapy, mme e kopantsoe le li-sequestrants tsa bile acid.

Pele le nakong ea kalafo, mokuli o lokela ho ja lijo tse matlafatsang.

Bakeng sa ho lahleheloa ke tekanyetso ea hona joale, moriana o lokela ho nooa kapele kamoo ho ka khonehang. Haeba ke nako ea tekanyetso e latelang, u se ke oa eketsa habeli tekanyetso.

Bakeng sa bakuli ba nang le bothata bo matla ba ho phekola ba renal, kalafo e etsoa ka tlasa taolo ea ts'ebetso ea renal.

Bakuli ba eletsoa hore ba tlalehe bohloko ba mesifa bo sa hlalosoang, mokhathala, kapa bofokoli, haholo haeba bo tsamaisana le malaise kapa feberu.

Ka tlhokomelo

Bakuli ba nang le bothata ba bokhoba ba tahi le bakuli ba fetisoang ke setho sa botona ba eletsoa ho etsa kalafo ea Simlo ka hloko e kholo.

Ho khothalletsoa ho ba hlokolosi hape ha ho e-na le mafu a tšoaetsanoang a tšoaetsanoang, haeba ho ka ba le mathata a tebileng a metabolic, ka nts'etsopele ea methapo ea kutlo, tlolong ea tekanyetso ea metsi-maemong, maemong a ts'ebetso ea ts'ebetso kapa likotsi.

Simlo e boetse e lokela ho nkuoa ka hloko ke bakuli ba nang le molumo oa mesifa o fetotsoeng, le lefu la ho akheha kapa ho tsuaroa ho sa laoleheng. Ka boteng ba efe kapa efe ea maemo a thathamisitsoeng, ho kgothaletswa ho nka moriana ona feela joalokaha o laetsoe ke ngaka.