Lantus SoloStar

Lithethefatsi Lantus SoloStar (Lantus solostar) e thehiloe ho analogue ea insulin ea motho, e nang le solubility e tlase tikolohong e sa nke lehlakore. Ka lebaka la tikoloho ea acidic ea tharollo Lantus SoloStar insulin glargine e felisitsoe ka botlalo, empa ka tsamaiso ea subcutaneous, asiti ha e nke lehlakore 'me microprecipitates e thehoa ka lebaka la phokotseho ea solubility, eo ho eona insulin e tsoang butle butle. Ka hona, keketseho ea butle-butle ea ho kenella ha insulin ntle le litlhoro tse bohale le phello ea nako e telele ea lithethefatsi Lantus SoloStar lia phethahala.
Ho insulin glargine le insulin ea motho, kinetics ea puisano le li-insulin receptors le eona e joalo. Sebaka le boemo ba insulin glargine bo tšoana le ba insulin ea motho.

Setlhare se laola metabolism ea tsoekere, haholoholo, e fokotsa tsitsipano ea glucose ka ho fokotsa tlhahiso ea eona ka har'a sebete le ho eketsa tšebeliso ea tsoekere ka lithane tse kenellang (haholo-holo mesifa le adipose tiske). Insulin e thibela protheine le lipolysis ho li-adipocytes, hape e ntlafatsa tšebeliso ea protheine.
Ketso ea insulin glargine, e tsamaisoang ka mokhoa o sa ts'oaneng, e tsoela pele butle butle ho feta ka ho hlahisoa ha NPH ea insulin, mme e bonts'oa ke ketso e telele le ho se be teng hoa boleng bo phahameng. Ka tsela ena Lantus SoloStar e ka sebelisoa nako e le 'ngoe ka letsatsi. Hopola hore katleho le nako ea insulin e ka fapana haholo ho motho a le mong (ka ho ikoetlisa ka matla, ho eketsa kapa ho fokotsa khatello ea maikutlo, jj.).

Phuputsong e bulehileng ea kliniki, ho ile ha netefatsoa hore insulin glargine ha e eketse tsoelo-pele ea lefu la tsoekere (matšoao a kliniki bakeng sa ts'ebeliso ea insulin glargine le insulin ea motho e ne e sa fapana).
Ha u sebelisa lithethefatsi Lantus SoloStar tekanyo ea insulin ea insulin e fumanoe ka letsatsi la 2-4.
Insulin glargine e tšeloa 'mele' meleng ho theha metabolites tse peli tse sebetsang, M1 le M2. Karolo ea bohlokoa phethahatsong ea litlamorao tsa lithethefatsi Lantus SoloStar e bapaloa ke metabolite M1, ho plasma e sa fetoheng ea insulin glargine le metabolite M2 li ile tsa beoa ka tekanyo e nyane.
Ho ne ho se na phapang e kholo ho katleho le polokeho ea insulin glargine ho bakuli ba lihlopha tse fapaneng le bongata ba bakuli ka kakaretso.

Matšoao a sebeliso:
Lantus SoloStar e sebelisoang bakeng sa kalafo ea bakuli ba kaholimo ho lilemo tse 6 ba nang le lefu la tsoekere le lahleloang ke lefu la tsoekere.

Mokhoa oa ts'ebeliso:
Lantus SoloStar e etselitsoe tsamaiso e potolohileng. Ho khothalletsoa ho hlahisa moriana oa lithethefatsi Lantus SoloStar ka nako e ts'oanang ea letsatsi. Tekanyetso ea lithethefatsi Lantus SoloStar e khethoa ka bomong ke ngaka. Re lokela ho hopola hore litekanyetso tsa moriana li hlahisoa ka likarolo tsa ts'ebetso tse ikhethileng mme li ke keng tsa bapisoa le likarolo tsa ts'ebetso ea li-insulin tse ling.
Tšebeliso ea lithethefatsi e lumelloa Lantus SoloStar ho bakuli ba nang le mofuta oa lefu la tsoekere la mofuta oa 2 hammoho le mahlahana a molomo.

Ho tloha insulin tse ling ho Lantus SoloStar:
Ha o fetohela ho Lantus SoloStar le li-insulin tse ling tse pakeng kapa tse telele, ho ka ba le tlhoko ea ho fetola tekanyetso ea letsatsi le letsatsi ea insal insulin, hammoho le ho fetola litekanyetso le kemiso ea ho sebelisa lithethefatsi tse ling tsa hypoglycemic. Ho fokotsa kotsi ea nocturnal hypoglycemia nakong ea phetoho ea Lantus SoloStar nakong ea libeke tse 'maloa tse qalang, ho kgothaletsoa ho theola tekanyetso ea insulin le khalemelo e nepahetseng ea insulin, e hlahisoang mabapi le tšebeliso ea lijo. Libeke tse 'maloa ka mor'a ho qaleha ha lithethefatsi Lantus SoloStar, ho etsoa tokiso ea lethal la insulin le insulin tse nkang nakoana.
Ho bakuli ba fumanang insulin nako e telele, ponahalo ea li-antibodies ho insulin le ho fokotseha hoa karabelo ho tsamaiso ea lithethefatsi Lantus SoloStar lia khonahala.
Ha o tloha ho insulin e 'ngoe o ea ho e' ngoe, hammoho le nakong ea tokiso ea litekanyetso, maemo a tsoekere ea plasma a lokela ho hlahlojoa ka hloko haholo.

Kenyelletso ea lithethefatsi Lantus SoloStar:
Setlhare sena se tsamaisoa ka mokhoa o ikhethileng tikolohong ea deltoid, thipa kapa mpa. Ho khothalletsoa ho fetola setsi sa ente kahare ho libaka tse amohelehang ho jarete e ngoe le e ngoe ea Lantus SoloStar. Ha hoa lumelloa ho tsamaisa Lantus SoloStar kahare (ka lebaka la kotsi ea ho sebelisa tekano le ho hola ha hypoglycemia e matla).
Ha hoa lumelloa ho kopanya tharollo ea insulin glargine le meriana e meng.
Hang-hang pele ho ts'ebetso ea insulin glargine, tlosa lipompo tsa moea ka sejelong ebe u etsa tlhahlobo ea polokeho. Ente e 'ngoe le e' ngoe e lokela ho etsoa ka nale e ncha, e kenngoang pene ea syringe hang pele u sebelisa moriana.

Ho sebelisa pente ea Syringe Lantus SoloStar:
Pele o sebelisoa, o lokela ho hlahloba mokotla oa pente ea syringe ka hloko, o ka sebelisa tharollo e hlakileng ntle le ho qhekelloa. Haeba motho a ka hlaha morusu kapa o fetoha, kapa a feto-fetoha ha 'mala oa tharollo, tšebeliso ea lithethefatsi e thibetsoe. Ho lokela ho lahloa lipentšele tse se nang letho. Haeba pente ea syringe e senyehile, o lokela ho nka pene e ncha ea syringe ebe o lahla e senyehileng.

Pele ho ente e 'ngoe le e' ngoe, tlhahlobo ea polokeho e lokela ho etsoa:
Hlahloba ho fumana tharollo ea insulin le ponahalo ea tharollo.
2. Tlosa mokokotlo oa pene ea syringe ebe o hokela nale e ncha (nale e lokela ho hatisoa hang-hang pele e kenella, ho thibetsoe ho kenya nale ka sekontiri).
3. Lekanya tekanyo ea li-Units tse peli (haeba pene ea syringe e e-so sebelisoe li-Units tse 8) beha pene ea syringe ka nale, 'me u thelle mokotla ka thaole, tobetsa konopo ho kenya tsela eohle' me u shebe ponahalo ea lerotholi la insulin ntlheng ea nale.
4. Ha ho hlokahala, tlhahlobo ea polokeho e etsoa makhetlo a 'maloa ho fihlela tharollo e hlaha ntlheng ea nale. Haeba kamora liteko tse 'maloa insulin e sa hlahe, nka nale ena. Haeba mehato ena e sa thusa, pene ea syringe e na le phoso, u se ke oa e sebelisa.

Ho thibetsoe ho fetisetsa pente ea syringe ho batho ba bang.
Kamehla ho khothalletsoa ho ba le setlolo syringe pen Lantus SoloStar ha ho senyeha kapa ho lahleheloa ke pente ea syringe e sebelisitsoeng.
Haeba pene e bolokiloe sehatsetsing, e lokela ho tlosoa lihora tse 1-2 pele ho ente e le hore tharollo e futhumale ho fihlela mocheso oa kamore.
Pene ea syringe e lokela ho sireletsoa litšileng le lerōleng, u ka hloekisa karolo e ka ntle ea pene ka lesela le mongobo.

Ha hoa lumelloa ho hlatsoa pente ea syringe Lantus SoloStar.

Khetho ea mori:
Lantus SoloStar e o lumella ho beha lethal dose ho tloha ho yuniti e le ngoe ho isa ho tse 80 ka nyolohelo ea 1 unit. Ha ho hlokahala, kenya tekanyetso ea li-unit tse fetang 80 ho etsa liente tse 'maloa.
Etsa bonnete ba hore kamora tlhahlobo ea polokeho, fensetere ea dosing e bonts'a "0", khetha tekanyetso e hlokahalang ka ho fetola sethala sa dosing. Kamora ho khetha tekanyetso e nepahetseng, kenya nale ka lethekeng ebe o tobetsa konopo ho e kenya tseleng eohle. Kamora hore ho sebelisoe lethal dose, boleng ba "0" bo lokela ho beoa fensetereng ea dosing. Ha u siea nale ka letlalong, bala ho isa ho 10 'me u hule nale e tsoang letlalong.
Tlosa nale ka penereng ea syringe ebe u e lahla, u koale pene ea samente ka cap, ebe u boloka ho fihlela ente e latelang.

Litlamorao:
Ha u sebelisa lithethefatsi Lantus SoloStar ho bakuli, nts'etsopele ea hypoglycemia e ka etsahala, ka lebaka la ho hlahisoa ha lethal dose e phahameng ea insulin, le phetoho ea lijo, ho ikoetlisa ka 'mele le nts'etsopele / ho felisoa ha maemo a sithabetsang. Hypoglycemia e matla e ka baka kholo ea khatello ea methapo ea kutlo mme ea baka ts'abo bophelong ba mokuli.
Ntle le moo, ha u sebelisa lithethefatsi Lantus SoloStar nakong ea liteko tsa bongaka ho bakuli, ho ile ha hlokomeloa litla-morao tse latelang:
Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa kutlo: dysgeusia, retinopathy, e fokotse pono ea kelello. Hypoglycemia e matla e ka lebisa kholong ea tahlehelo ea nakoana ea pono ho bakuli ba nang le proliferative retinopathy.

Karolong ea letlalo le lisele tse poteletseng: lipodystrophy, lipoatrophy, lipohypertrophy.
Litlamorao: Lintho tse hloahloa tsa letlalo ka kakaretso, bronchospasm, anaphylactic, edema ea Quincke.
Litlamorao tsa lehae: hyperemia, edema, soreness le ts'oaetso ea ho ruruha setsing sa ente sa Lantus SoloStar.
Tse ling: bohloko ba mesifa, ho lula ha sodium 'meleng.
Boemo ba ts'ireletso ea lithethefatsi Lantus SoloStar ho bana ba fetang 6 lilemo le batho ba baholo lia tšoana.

Contraindication:
Lantus SoloStar se ke oa fa bakuli ba nang le hypersensitivity e tsebahalang ho insulin glargine kapa likarolo tse ling tse hlahisang tharollo.
Lantus SoloStar ha e sebelisoe ho phekola bakuli ba nang le bothata ba ho ruruha le ho senyeha haholo.
Boikoetlisong ba bana, lithethefatsi Lantus SoloStar e sebelisoang feela bakeng sa kalafo ea bana ba ka holimo ho lilemo tse 6.
Lantus SoloStar eseng lithethefatsi tsa khetho bakeng sa kalafo ea lefu la tsoekere la ketoacidosis.
Ho bakuli ba tsofetseng, hammoho le bakuli ba nang le bothata ba ho thatafala ha renal le hepatic, litlhoko tsa insulin li ka fokotseha, bakuli ba joalo ba lokela ho fuoa Lantus SoloStar ka tlhokomeliso (ka ho lekola khafetsa maemo a tsoekere ea plasma).
Ho lokela hore ho sebelisoe tlhokomeliso ha ho khethoa litekanyetso bakeng sa bakuli bao hypoglycemia e ka bang le litlamorao tse mpe.

Haholo-holo, ka tlhokomeliso, Lantus SoloStar e laeloa bakuli ba nang le lefu la mokokotlo kapa la coronary stenosis le proliferative retinopathy.

Ho lokela hore ho sebelisoe tlhokomeliso ha ho fanoa ka taelo ea Lantus SoloStar ho bakuli bao matšoao a hypoglycemia a sa bonahaleng kapa a le bonolo, ho kenyelletsa bakuli ba nang le ntlafatso ea indices ea glycemic, nalane ea nako e telele ea lefu la tsoekere, neuronomia ea kelello, lefu la kelello, nts'etsopele ea butle-butle ea hypoglycemia, hammoho le bakuli le bakuli ba tsofetseng. tse tsoang ho insulin ea liphoofolo ho ea ho motho.
Ho boetse ho lokela ho ba hlokolosi ha u fana ka litlhare. Lantus SoloStar bakuli ba nang le tloaelo ea ho ba le hypoglycemia. Kotsi ea ho ba le hypoglycemia e eketseha ka phetoho sebakeng sa tsamaiso ea insulin, keketseho ea kutloisiso ea insulin (ho kenyelletsa ho felisoa ha maemo a sithabetsang), ho eketseha ha mmele, phepo e mpe, ho hlatsa, lets'ollo, tšebeliso ea lino tse tahang, mafu a sa lefelloeng a tsamaiso ea endocrine, le ts'ebeliso ea meriana e itseng ( bona Tšebelisano le Meriana e Meng).
Bakuli ba nang le lefu la tsoekere ba lokela ho ba hlokolosi mabapi le ho sebetsana le mekhoa e sa sireletsehang; nts'etsopele ea hypoglycemia e ka lebisa ho tsekela le ho fokotseha ha khatello ea maikutlo.

Boimana
Ha ho na data ea kliniki mabapi le ts'ebeliso ea moriana Lantus SoloStar ho basali baimana. Lithutong tsa liphoofolo, ho se be teng ha litlamorao tsa teratogenic, mutagenic le embryotoxic tsa insulin glargine, hammoho le litlamorao tsa eona tse mpe ho ima le ho beleha bana li senotsoe. Haeba ho hlokahala, Lantus SoloStar e ka fuoa basali ba baimana. Bophahamo ba glucose ea plasma bo lokela ho beoa leihlo ka hloko ho basali ba baimana, ba fuoe liphetoho tsa litlhoko tsa insulin. Ka trimester ea pele, tlhoko ea insulin e ka fokotseha, 'me ea bobeli le ea boraro e batla e eketseha.

Hang ka mor'a ho hlaha, tlhoko ea insulin e fokotseha haholo mme ho na le kotsi ea hypoglycemia.

Nakong ea lebone, setlhare Lantus SoloStar e ka sebelisoa ka ho shebella ho tsoelang pele ha boemo ba glucose ba gluas. Ha ho na data mabapi le ho kenella ha insulin glargine ho lebese la matsoele, empa ka har'a tšilo ea lijo, insulin glargine e arotsoe ka li-amino acid mme e ke ke ea utloisa masea a macha bao 'm'a bona a fumanang pheko le Lantus SoloStar.

Ho sebelisana le lithethefatsi tse ling:
Ho sebetsa ha lithethefatsi Lantus SoloStar e ka fapana le ts'ebeliso e kopaneng ea lithethefatsi tse ling, haholo:
Li-ejenti tsa antidiabetic tsa molomo, angiotensin tse fetolelang li-enzyme inhibitors, monoamine oxidase inhibitors, salicylates, sulfanilamides, fluoxetine, propoxyphene, pentoxifylline, disopyramide le fiberrate li ka baka litlamorao tsa insulin glargine ha e sebelisoa hammoho.
Corticosteroids, diuretics, danazole, glucagon, diazoxide, estrogens le progestin, isoniazid, sympathomimetics, somatropin, protease inhibitors, lihomone tsa qoqotho le li-antipsychotic li fokotsa phello ea hypoglycemic ea lithethefatsi Lantus SoloStar.
Litlolo tsa Lithium, clonidine, pentamidine, ethyl alcohol le beta-adrenoreceptor blockers li ka ba le monyetla oa ho fokotsa phello ea hypoglycemic ea lithethefatsi Lantus SoloStar.
Lantus SoloStar e fokotsa botebo ba litlamorao tsa clonidine, reserpine, guanethidine le beta-adrenergic blockers.

Bongata
Ka tšebeliso e feteletseng ea insulin glargine, bakuli ba hlaolela hypoglycemia ea mefuta e fapaneng ea boima. Ka hypoglycemia e matla, nts'etsopele ea ho ts'oaroa, komello le khatello ea methapo lia khoneha.
Sesosa sa lithethefatsi tse ngata Lantus SoloStar ho ka ba le phetoho ea dosing (tsamaiso ea lethal dose e phahameng), ho tlōla lijo, ho eketsa boima ba 'mele, ho hlatsa le lets'ollo, mafu a fokotsang tlhoko ea insulin (ho kenyelletsa mesebetsi ea mokokotlo ea mokokotlo le hepatic, hypofunction ea gland ea pituitary, adrenal cortex kapa gland ea qoqotho). kenyelletso ea lithethefatsi Lantus SoloStar.

Mefuta e bonolo ea hypoglycemia e lokisoa ke tšebeliso ea 'mele ea nama ea nama ea kolobe (o lokela ho fa mokuli nako e telele le ho lekola boemo ba hae, kaha lithethefatsi Lantus SoloStar li na le tšusumetso ea nako e telele).
Ka hypoglycemia e matla (ho kenyelletsa le lipontšo tsa methapo), tsamaiso ea glucagon (subcutaneally kapa intramuscularly) kapa tsamaiso ea methapo ea tharollo ea glucose e kenelletseng e bontšoa.
Boemo ba mokuli bo lokela ho beoa leihlo bonyane lihora tse 24, hobane liketsahalo tsa hypoglycemia li ka khutla kamora ho emisa tlhaselo ea hypoglycemia le ho ntlafatsa boemo ba mokuli.

Foromo ea tokollo:
Tharollo ea liente Lantus SoloStar Li-3m tsa li-cartridge tsa hae li kentsoe ka pene ea litšila tse ka li phelisang, lipene tse 5 tsa sindako ntle le nale, li kenngoa ka lebokoseng la karete.

Maemo a polokelo:
Lantus SoloStar ha ea lokela ho bolokoa nako e sa feteng lilemo tse 3 kamora ho etsoa ka likamoreng moo mmuso oa mocheso o bolokiloeng ho tloha ho 2 ho isa ho 8 Celsius. Boloka pene e le hore bana ba e fihle. E hanetsoe ho theola tharollo Lantus SoloStar.
Kamora ts'ebeliso ea pele, pene ea syringe e ka sebelisoa matsatsi a sa feteng 28. Kamora ho qala ts'ebeliso, pene ea syringe e lokela ho bolokoa ka likamoreng tse nang le mocheso oa likhato tse 15 ho isa ho 25 tsa Celsius.

Moetso:
1 ml Tharollo ea ente Lantus SoloStar E na:
Insulin glargine - 3.6378 mg (e lekanang le likarolo tsa 100 tsa insulin glargine),
Lithako tse ling.