Heinemox ea lithethefatsi: litaelo tsa tšebeliso

Matlapa, a koahetsoeng ka koae e bofubelu ba bofubelu, a entsoe ka ovic, biconvex, le notch, nakong ea khefu - bongata ho tloha ho tšoeu ho isa ho mosehla o moputsoa o nang le botala bo bosehla.

Bahlomphehi: poone starch - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, talc e hloekisitsoeng - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl starch - 20 mg, anrogenrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg microcrystalline cellulose - 130,7 mg.

Sebopeho sa Shell: Opadry e tšoeu 85G58997 Makc-Colorcon (joala ba polyvinyl, titanium dioxide, talc, macrogol 3000, lecithin (soy) - 17.32 mg, oxide e khubelu ea tšepe - 0,68 mg.

Li-pcs tse 5. - Mabokose (1) - liphutheloana tsa karete.
7 likhomphutha - Mabokose (1) - liphutheloana tsa karete.
Li-pcs tse 10 - Mabokose (1) - liphutheloana tsa karete.
Li-pcs tse 5. - Mabokose (2) - lipakete tsa karete.
7 likhomphutha - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 10 - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 5. - marang-rang (10) - lipakete tsa karete.
7 likhomphutha - marang-rang (10) - lipakete tsa karete.
Li-pcs tse 10 - marang-rang (10) - lipakete tsa karete.
Li-pcs tse 100 - mekotla (1) (ea lipetlele) - makotikoti a polasetiki.
Li-pcs tse 500 - mekotla (1) (ea lipetlele) - makotikoti a polasetiki.
Li-pcs tse 1000 - mekotla (1) (ea lipetlele) - makotikoti a polasetiki.

Ketso ea pharmacological

Sebaka sa antimicrobial sehlopheng sa fluoroquinolones, se sebetsa ka bactericidal. E sebetsa khahlano le mefuta e fapaneng ea likokoana-hloko tsa gram-positive le gram-negative, anaerobic, acid e thibelang acid le atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. E sebetsa hantle khahlanong le mefuta ea libaktheria e hanyetsanang le beta-lactams le macrolides. E sebetsa khahlano le mefuta e mengata ea likokoana-hloko: gram-positive - Staphylococcus aureus (ho kenyelletsa le lintho tse sa tsotelleng ho methicillin), Streptococcus pneumoniae (ho kenyelletsa le mefuta e hananang le penicillin le macrolides), Streptococcus pyogene (sehlopha A), gram-negative - Haemophilus influenzae le mefuta e seng ea beta-lactamase e hlahisang), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (ho kenyelletsa mefuta e sa hlahiseng beta le e seng beta-lactamase e hlahisang), Escherichia coli, Enterobacter cloacae, atypical Chlamydia pneumonia. Ho ea ka liphuputso tsa in vitro, le ha likokoana-hloko tse thathamisitsoeng ka tlase li tsotella moxifloxacin, leha ho le joalo, ts'ireletso ea eona le ts'ebetso ea eona ea ho phekola tšoaetso ha e e-so thehoe. tse phelang a mob mobile ea HIV: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (ho akarelletsa le mefuta e, methicillin nahanela), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Likokoana-hloko tse seng ntle tsa Gram: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogene, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Likokoana-hloko tsa Atypical: Legionella pneumophila, Caxiella burnettii.

Li-blocks topoisomerases II le IV, li-enzyme tse laolang lintho tsa mantlha tsa DNA, hape li kenelletse phetolelong ea DNA, ho e lokisa le ho etsoang. Matla a moxifloxacin a ipapisitse le khatello ea ona maling le liseleng. Metsotso e fokolang ea bactericidal e batlang e sa fapana le maemo a fokolang a thibelitsoeng.

Mekhoa ea ho hanyetsa mokhoa oa ho hanyetsa, ho kenya penicillin, cephalosporins, aminoglycosides, macrolides le tetracyclines, ha e ame mosebetsi oa antibacterial oa moxifloxacin. Ha ho na khanyetso pakeng tsa moxifloxacin le lithethefatsi tsena. Mokhoa oa nts'etsopele ea plasmid-Mediated hanyane ha oa ka oa bonoa. Liketsahalo tsohle tsa ho hanyetsa li tlase. Liphuputso tsa in vitro li bontšitse hore ho hanyetsa moxifloxacin ho hlaha butle butle ka lebaka la letoto la liphetoho tse latellanang. Ka ho pepesetsoa khafetsa likokoana-hloko tse nang le moxifloxacin maemong a fokolang a thibelitsoeng, matšoao a BMD a eketseha hanyane feela. Ho hanyetsa ka sefapano ho bonoa pakeng tsa lithethefatsi ho tsoa sehlopheng sa fluoroquinolone. Leha ho le joalo, likokoana-hloko tse ling tsa gram-positive le anaerobic tse hananang le fluoroquinolones tse ling li tsotella moxifloxacin.

Mofumahali

Kamora ho tsamaisoa ka molomo, moxifloxacin e kenngoa ka potlako mme e batla e le ka botlalo. Kamora tekanyetso e le 'ngoe ea moxifloxacin ka tekanyetso ea max mg C max maling e fumaneha ka nako ea lihora tse 0.5-4 mme ke 3.1 mg / L.

Kamora ho kenngoa ka mokhoa o le mong ka tekanyetso ea 400 mg bakeng sa 1 h, C max e fihlella qetellong ea infusion mme ke 4.1 mg / l, e tsamaellanang le keketseho ea hoo e ka bang 26% ha e bapisoa le boleng ba letšoao lena ha le nkuoa ka molomo. Ka infusions tse ngata tsa IV ka tekanyetso ea 400 mg bakeng sa hora e le 'ngoe, C max e fapana ka bongata ho tloha ho 4.1 mg / l ho isa ho 5.9 mg / l. Karolelano ea C ss ea 4,4 mg / L e fihlella qetellong ea infusion.

Boaoavailability e felletseng e ka ba 91%.

The pharmacokinetics ea moxifloxacin ha e nooa ka tekanyetso e le 'ngoe ho tloha ho 50 mg ho isa ho 1200 mg, hammoho le tekanyo ea 600 mg / ka letsatsi bakeng sa matsatsi a 10, e mola.

Mmuso oa tekano o fihlelloa nakong ea matsatsi a 3.

Ho ikopanya le liprotheine tsa mali (haholo-holo albin) ke hoo e ka bang 45%.

Moxifloxacin e ajoa ka potlako ho litho le lisele. V d ke hoo e ka bang 2 l / kg.

Ho tsepamisa mohopolo o phahameng oa moxifloxacin, e fetisang e leng plasma, e bōpiloe ka liseleng tsa matšoafo (ho kenyelletsa le alveolar macrophages), ka mucous membrane ea bronchi, mokhoeng oa kahare, ka lisele tse bonolo, letlalo le likarolo tse poteletseng. Ka mokelikeli oa methapo le matheong, moriana o khethoa ka foromo e sa lefelloeng, e senang protheine, pokellong e phahameng ho feta plasma. Ntle le moo, lintlha tse phahameng tsa ntho e sebetsang li hlahisoa ka har'a litho tsa ka mpeng le mokelikeling oa litho tsa botona le botšehali.

Biotransformed ho metsoako e sa sebetseng ea soffo le glucuronides. Moxifloxacin ha e ea biotransformed ke microsomal sebete enzymes ea cytochrome P450 system.

Kamora ho fetela mohatong oa bobeli oa biotransformation, moxifloxacin e nkuoa ho tsoa 'meleng ke liphio le mala, ka bobeli e sa fetoheng' me e le mofuta oa metsoako e sa sebetseng ea sirapo le glucuronides.

E pepesitsoe ka har'a moroto, hammoho le makhopho, a sa fetoloeng le a mofuta oa metabolites e sa sebetseng. Ka tekanyo e le 'ngoe ea 400 mg, hoo e ka bang 19% ha e hlahisoe ntle ho moroto, e ka ba 25% e nang le makhopho. T 1/2 ke hoo e ka bang lihora tse 12.

Matšoao le litekanyetso:

pneumonia e fumanoeng ke sechaba, ho kenyelletsa le pneumonia e fumanoeng ke sechaba, bao e leng lisosa tsa likokoana-hloko tseo e leng likokoana-hloko tse sa bonahaleng tse ngata tse hanyetsanang le lithethefatsi tse thibelang likokoana-hloko *

sinusitis ea hlobaetsang

tšoaetso e sa rarahanang le e rarahaneng ea letlalo le lisele tse bonolo (ho kenyeletsoa leoto la tsoekere le tšoaelitsoeng),

tšoaetso e rarahaneng ea ka mpeng, ho kenyelletsa le tšoaetso ea polymicrobial, ho kenyeletsoa hanglsabella

mafu a sa rarahanang a amang litho tsa ka hare (ho kenyeletsa le salpingitis le endometritis).

Nka li-hinemok kahare, ho metsa ka botlalo, eseng ho hlafuna, ho noa metsi a mangata, haholo-holo ka mor'a ho ja. Se ke oa feta tekanyetso e khothalletsoang.

Ts'oaetso ea tšoaetso e ka bang lihora tse 24 (nako e le 'ngoe ka letsatsi), mg Nako ea kalafo, matsatsi a sechaba a fumanoeng pneumonia 4007-14 Ho eketseha ha tšoaetso ea lefu la mokokotlo 4005-10 Ho kenella habonolo ha ts'oaetso ea baktheria ea letlalo le likarolo tse 4007 Tse rarahaneng tsa ts'oaetso ea letlalo le likarolo tse bonolo tsa litho tse 147 - 21

Se ke oa feta kalafo e khothalelitsoeng.

Ha ho phetoho ea mofuta oa kalafo ea litekanyetso e hlokahalang: ho bakuli ba tsofetseng, bakuli ba nang le ts'ebetso ea sebete e sa sebetseng (sehlopha sa A, B sethaleng sa bana-Pugh), bakuli ba nang le ts'ebetso ea renal e sa sebetseng (ho kenyelletsa le ho hloleha ho matla ha renal le "creatinine Cl" min / 1.73 m2, hammoho le tse ntseng li tsoela pele ka hemodialysis le nako e telele ea oritatial dialysis), bakuli ba merabe e fapaneng.

Litlamorao

Boitšoaro bo kulang ho likarolo tsa Heinemox: lekhopho, ho hlohlona, ​​urticaria.

Ho tsoa ho ts'ebetso ea pelo: tachycardia, edema ea potoloho, khatello e phahameng ea mali, palpitations, bohloko ba sefuba.

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho opeloa ke mpa, ho nyekeloa ke pelo, lets'ollo, ho hlatsa, dyspepsia, botlaaseng, ho sokela, ho eketseha hoa ts'ebetso ea transaminase ea hepatic, tatso e litšila.

Karolong ea li-paramente tsa laboratori: ho fokotseha ha boemo ba prothrombin, keketseho ea mesebetsi ea amylase.

Ho tsoa ho tsamaiso ea hemopoietic: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, anemia.

Ho tloha lehlakoreng la methapo ea methapo e bohareng le tsamaiso ea methapo ea methapo: ho tsekela, ho hloka boroko, ho tšoha, ho tšoenyeha, asthenia, hlooho ea hlooho, ho thothomela, paresthesia, bohloko ba leoto, mesifa, pherekano, khatello ea maikutlo.

Ho tsoa tsamaisong ea musculoskeletal: bohloko ba morao, arthralgia, myalgia.

Ho tsoa ts'ebetsong ea kemolo: vagi candidiasis, vaginitis.

Lipotso, likarabo, litlhahlobo mabapi le lithethefatsi Heinemoks

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebeletsang e le sebaka sa boipiletso ba motho ho setsebi.

Tlhophiso ea Nosological (ICD-10)

Sebopeho le mofuta oa tokollo

Matlapa - Letlapa le le leng:

• Ntho e sebetsang: moxifloxacin hydrochloride 436.3 mg, e tsamaellanang le se ka har'a moxifloxacin 400 mg.
• Baeti: starch ea poone - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, talc e hloekisitsoeng - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl starch - 20 mg, anhydrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg, microcrystalline cellulose - 130.7 mg.
• Sebopeho sa Shell: Opadry e tšoeu 85G58997 Makc-Colorcon (joala ba polyvinyl, titanium dioxide, talc, macrogol 3000, lecithin (soy) - 17.32 mg, oxide e khubelu ea tšepe - 0,68 mg.

Li-pcs tse 5. - Mabokose (1) - liphutheloana tsa karete.

Matlapa, a koahetsoeng ka koae e bofubelu ba bofubelu, a entsoe ka ovic, biconvex, le notch, nakong ea khefu - bongata ho tloha ho tšoeu ho isa ho mosehla o moputsoa o nang le botala bo bosehla.

Sebaka sa antimicrobial sehlopheng sa fluoroquinolones, se sebetsa ka bactericidal. E sebetsa khahlano le mefuta e fapaneng ea likokoana-hloko tsa gram-positive le gram-negative, anaerobic, acid e thibelang acid le atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. E sebetsa hantle khahlanong le mefuta ea libaktheria e hanyetsanang le beta-lactams le macrolides. E sebetsa khahlano le mefuta e mengata ea likokoana-hloko: gram-positive - Staphylococcus aureus (ho kenyelletsa le lintho tse sa tsotelleng ho methicillin), Streptococcus pneumoniae (ho kenyelletsa le mefuta e hananang le penicillin le macrolides), Streptococcus pyogene (sehlopha A), gram-negative - Haemophilus influenzae le mefuta e seng ea beta-lactamase e hlahisang), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (ho kenyelletsa mefuta e sa hlahiseng beta le e seng beta-lactamase e hlahisang), Escherichia coli, Enterobacter cloacae, atypical Chlamydia pneumonia. Ho ea ka liphuputso tsa in vitro, le ha likokoana-hloko tse thathamisitsoeng ka tlase li tsotella moxifloxacin, leha ho le joalo, ts'ireletso ea eona le ts'ebetso ea eona ea ho phekola tšoaetso ha e e-so thehoe. tse phelang a mob mobile ea HIV: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (ho akarelletsa le mefuta e, methicillin nahanela), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Likokoana-hloko tse seng ntle tsa Gram: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogene, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Likokoana-hloko tsa Atypical: Legionella pneumophila, Caxiella burnettii.

Li-blocks topoisomerases II le IV, li-enzyme tse laolang lintho tsa mantlha tsa DNA, hape li kenelletse phetolelong ea DNA, ho e lokisa le ho etsoang. Matla a moxifloxacin a ipapisitse le khatello ea ona maling le liseleng. Metsotso e fokolang ea bactericidal e batlang e sa fapana le maemo a fokolang a thibelitsoeng.

Mekhoa ea ho hanyetsa mokhoa oa ho hanyetsa, ho kenya penicillin, cephalosporins, aminoglycosides, macrolides le tetracyclines, ha e ame mosebetsi oa antibacterial oa moxifloxacin. Ha ho na khanyetso pakeng tsa moxifloxacin le lithethefatsi tsena. Mokhoa oa nts'etsopele ea plasmid-Mediated hanyane ha oa ka oa bonoa. Liketsahalo tsohle tsa ho hanyetsa li tlase. Liphuputso tsa in vitro li bontšitse hore ho hanyetsa moxifloxacin ho hlaha butle butle ka lebaka la letoto la liphetoho tse latellanang. Ka ho pepesetsoa khafetsa likokoana-hloko tse nang le moxifloxacin maemong a fokolang a thibelitsoeng, matšoao a BMD a eketseha hanyane feela. Ho hanyetsa ka sefapano ho bonoa pakeng tsa lithethefatsi ho tsoa sehlopheng sa fluoroquinolone. Leha ho le joalo, likokoana-hloko tse ling tsa gram-positive le anaerobic tse hananang le fluoroquinolones tse ling li tsotella moxifloxacin.

Kamora ho tsamaisoa ka molomo, moxifloxacin e kenngoa ka potlako mme e batla e le ka botlalo. Kamora tekanyetso e le 'ngoe ea moxifloxacin ka tekanyo ea 400 mg C _max maling a fihlella ka nako ea lihora tse 0.5-4 mme ke 3.1 mg / l.

Kamora ho kenngoa ka mokhoa o le mong ka tekanyetso ea 400 mg bakeng sa 1 h C _max e fumaneha qetellong ea infusion mme ke 4.1 mg / l, e tsamaellanang le keketseho ea hoo e ka bang 26% ha e bapisoa le boleng ba letšoao lena ha le nkuoa ka molomo. Ka li-infusions tse ngata tsa IV maemong a 400 mg a lulang a le 1 h C _max e fapana ka bongata ho tloha ho 4,5 mg / l ho isa ho 5.9 mg / l. Karolelano ea Css ea 4.4 mg / L e fihlella qetellong ea infusion.

Boaoavailability e felletseng e ka ba 91%.

The pharmacokinetics ea moxifloxacin ha e nooa ka tekanyetso e le 'ngoe ho tloha ho 50 mg ho isa ho 1200 mg, hammoho le tekanyo ea 600 mg / ka letsatsi bakeng sa matsatsi a 10, e mola.

Mmuso oa tekano o fihlelloa nakong ea matsatsi a 3.

Ho ikopanya le liprotheine tsa mali (haholo-holo albin) ke hoo e ka bang 45%.

Moxifloxacin e ajoa ka potlako ho litho le lisele. Vd e ka ba 2 L / kg.

Ho tsepamisa mohopolo o phahameng oa moxifloxacin, e fetisang e leng plasma, e bōpiloe ka liseleng tsa matšoafo (ho kenyelletsa le alveolar macrophages), ka mucous membrane ea bronchi, mokhoeng oa kahare, liseleng tse bonolo, letlalo le likarolo tse thellang. Ka mokelikeli oa methapo le matheong, moriana o khethoa ka foromo e sa lefelloeng, e senang protheine, pokellong e phahameng ho feta plasma. Ntle le moo, lintlha tse phahameng tsa ntho e sebetsang li hlahisoa ka har'a litho tsa ka mpeng le mokelikeling oa litho tsa botona le botšehali.

Biotransformed ho metsoako e sa sebetseng ea soffo le glucuronides. Moxifloxacin ha e ea biotransformed ke microsomal sebete enzymes ea cytochrome P450 system.

Kamora ho fetela mohatong oa bobeli oa biotransformation, moxifloxacin e nkuoa ho tsoa 'meleng ke liphio le mala, ka bobeli e sa fetoheng' me e le mofuta oa metsoako e meng e sa sebetseng ea sirapo le glucuronides.

E pepesitsoe ka har'a moroto, hammoho le makhopho, a sa fetoloeng le a mofuta oa metabolites e sa sebetseng. Ka tekanyo e le 'ngoe ea 400 mg, hoo e ka bang 19% ha e hlahisoe ntle ho moroto, e ka ba 25% e nang le makhopho. T1 / 2 ke hoo e ka bang lihora tse 12. Kakaretso ea tumello ka botlalo kamora ho ba ea lethal dose ea 400 mg e tsoa ho 179 ml / min ho isa ho 246 ml / min.

Setlhare sa antibacterial sa sehlopha sa fluoroquinolone.

Tekanyetso ea Heinemox

Ka hare, 400 mg 1 nako / letsatsi. Nako ea kalafo bakeng sa ho mpefatsa ha mafu a sa foleng a bronchitis - matsatsi a 5, pneumonia e fumanoeng ke sechaba - matsatsi a 10, sinusitis e matla, tšoaetso ea letlalo le lisele tse bonolo - matsatsi a 7.

Moxifloxacin e laetsoe ka hloko ha ho ka ba le lefu la sethoathoa (ho kenyeletsa nalane), lefu la sethoathoa, ho hloleha ha sebete, letšoao la ho eketsa nako ea QT.

Nakong ea phekolo e nang le fluoroquinolones, ho ruruha le ho phatloha ha tendon ho ka hlaha, haholo ho bakuli ba tsofetseng le ho bakuli ba amohelang li-corticosteroids ka nako e tšoanang. Ka matšoao a pele a bohloko kapa ho ruruha ha methapo, bakuli ba lokela ho emisa kalafo mme ba lokolle leoto le amehang mojaro.

Pharadodynamics

Moxifloxacin ke sethethefatsi se thibelang likokoana-hloko se thibelang likokoana-hloko ka bongata ba mofuta oa fluoroquinolone, 8-methoxy fluoroquinolone. E sitisa topoisomerase II le topoisomerase IV, e sitisa ho kopanya le ho hokahanya ha marang-rang a DNA, e thibela synthes ea DNA, e bakang liphetoho tse tebileng tsa morphological ho cytoplasm, leboteng la sele le likarolo tsa likokoana-hloko tse bobebe.Metsotso e nyane ea bactericidal ea moxifloxacin hangata e bapisoa le botebo ba eona bo fokolang ba inhibitory (MICs).

Mechine e isang nts'etsopele ea ho hanyetsa li-penicillin, cephalosporins, aminoglycosides, macrolides le tetracyclines ha e khahlanong le ts'ebetso ea antibacterial ea moxifloxacin. Ha ho na khanyetso pakeng tsa lihlopha tsena tsa lithethefatsi tsa antibacterial le moxifloxacin. Ho fihlela hajoale, ha ho e-so be le maemo a hanyetsano ea plasmid. Khafetsa e akaretsang ea kholo ea khanyetsano e nyane haholo (10 -7-10 -10). Ho hanyetsa moxifloxacin ho hlaha butle butle ka liphetoho tse ngata. Tšusumetso e pheta-phetoang ea moxifloxacin ho likokoana-hloko tse ngata tse ka tlas'a MIC e tsamaisana le keketseho e nyane ho MIC. Ho hlokomeleha maemo a ho hanyetsoa ha quinolones. Leha ho le joalo, likokoana-hloko tse ling tse ntle tsa gram le anaerobic tse hanyetsanang le li-quinolones tse ling li lula li le kotsing ea moxifloxacin.

Moxifloxacin in vitro e sebetsa khahlano le likokoana-hloko tse fapaneng tsa gram-negative le gram-positive, anaerobes, libaktheria tse thibelang acid le libaktheria tsa atypical joalo ka Mycoplasma spp., Chlamydia spp., Legionella spp.hammoho le libaktheria tse hanyetsanang le lithibela-mafu tsa beta-lactam le macrolide.

Kakaretso ea mesebetsi ea antibacterial ea moxifloxacin e kenyelletsa likokoana-hloko tse latelang.

E ntle feela: Gardnerella vaginalis, Streptococcus pneumoniae * (ho kenyelletsa likarolo tse loantšang penicillin le likarolo tse hanyetsanang le meriana e thibelang likokoana-hloko tse ngata), Streptococcus pyogene (sehlopha A) *, sehlopha Streptococcus milleri (S. anginosus *, S. constellatus *, S. intermedius *), sehlopha Streptococcus viridans (S. viridans, S. mutans, S. mitis, S. sanguinis, S. salivarius, S. thermophilus, S. constellatus), Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus aureus (ho kenyeletsoa likarolo tsa methapo ea methapo ea methapo ea kutlo) *, coagulase-negative staphylococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans), ho kenyelletsa le likarolo tsa methapo ea methapo ea methapo.

Ha e na grram: Haemophilus influenzae (ho kenyelletsa le mefuta e hlahisang beta-lactamase) *, Haemophilus parainfluenzae *, Moraxella catarrhalis (ho kenyelletsa le mefuta e hlahisang beta-lactamase) *, Bordetella pertussis, Legionella pneumophila, Acinetobacter baumannii, Proteus vulgaris.

Anaerobes: Fusobacterium spp., Porphyromonas spp., Prevotella spp., Propionibacterium spp.

Mohlolo: Chlamydia pneumoniae *, Chlamydia trachomatis *, Mycoplasma pneumoniae *, Mycoplasma hominis, Mycoplasma genitalium, Legionella pneumophila *, Coxiella burnetii.

E ntle feela: Enterococcus faecalis * (feela likarolo tse amehang ho vancomycin le glamicin) Enterococcus avium *, Enterococcus faecium *.

Ha e na grram: Escherichia coli *, Klebsiella pneumoniae *, Klebsiella oxytoca, Citrobacter freundii *, Enterobacter spp. (E. aerogenes, E. intermedius, E. sakazakii), Enterobacter cloacae *, baetsi ba litaba tsa Pantoea, Pseudomonas fluorescens, Burkholderia cepacia, Stenotrophomonas maltophilia, Proteus mirabilis *, Morganella morganii, Neisseria gonorrhoeae * Prov. (P. rettgeri, P. stuartii).

Anaerobes: Bacteroides spp. (B. fragilis *, B. distasonis *, B. thetaiotaomicron *, B. ovatus *, B. sareis *, B. vulgaris *), Peptostreptococcus spp., Clostridium spp.

E ntle feela: Staphylococcus aureus (methicillin / ofloxacin antiistrain) **, coagulase-negative staphylococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans)Metsoako ea methicillin.

Ha e na grram: Pseudomonas aeruginosa.

* Sensitivity ho moxifloxacin e netefatsoa ke data ea kliniki.

** Ts'ebeliso ea Heinemox ha e khothalletsoe kalafo ea ts'oaetso e bakoang ke lits'oants'o. S. aureuskhahlanong le methicillin (MRSA). Maemong a tšoaetso e belaelloang kapa e netefalitsoeng e bakoang ke MRSA, kalafo e nang le lithethefatsi tse nepahetseng tsa antibacterial e lokela ho fanoa.

Pontšo Heinemox

Mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke likokoana-hloko tse amang moxifloxacin:

pneumonia e fumanoeng ke sechaba, ho kenyelletsa le pneumonia e fumanoeng ke sechaba, bao e leng lisosa tsa likokoana-hloko tseo e leng likokoana-hloko tse sa bonahaleng tse ngata tse hanyetsanang le lithethefatsi tse thibelang likokoana-hloko *

ho mpefala ha bronchitis e sa foleng,

sinusitis ea hlobaetsang

tšoaetso e sa rarahanang le e rarahaneng ea letlalo le lisele tse bonolo (ho kenyeletsoa leoto la tsoekere le tšoaelitsoeng),

tšoaetso e rarahaneng ea ka mpeng, ho kenyelletsa le tšoaetso ea polymicrobial, ho kenyeletsoa hanglsabella

mafu a sa rarahanang a amang litho tsa ka hare (ho kenyeletsa le salpingitis le endometritis).

* Streptococcus pneumoniae ka ho loants'oa tse thibelang likokoana-hloko tse ngata ho kenyelletsa likarolo tsa 'mele tse loantšang penicillin le likokoana-hloko tse hanyetsanang le lithibela-mafu tse peli kapa ho feta tse tsoang lihlopheng tse kang penicillin (e nang le MICs ≥ 2 μg / ml), cephalosporins ea molokong oa bobeli (cefuroxime), macrolides, tetracyclines le trimethoprim / sulfamethoxazole.

Contraindication

hypersensitivity ho moxifloxacin, li-quinolone tse ling kapa likarolo tse ling tsa lithethefatsi,

ho hlaseloa ke lintho tsa tlhaho kapa li-soya,

Tšenyo ea tendon ka kalafo e fetileng e nang le li-quinolones,

Tsamaiso e le 'ngoe ea lithethefatsi tse eketsang nako ea QT (ho kenyeletsa le lithethefatsi tsa antiarrhythmic tsa sehlopha sa IA, III) - bona "Tšebelisano",

bakuli ba nang le nako e telele ea QT e fumanehang, likotsi tsa electrolyte (haholo-holo tse sa hlophisitsoeng), li-bradycardia tsa bohlokoa tsa bongaka, ho nyeleha hoa pelo ka sekhahla ka karolo e fokolitsoeng ea ejection e fokolang, nalane ea meferefere e tsamaeang le matšoao a kliniki (ts'ebeliso ea moxifloxacin Q e lebisa ho ),

bakuli ba nang le ts'ebetso ea sebete e sa sebetseng (class-Pugh class C) le keketseho ea ts'ebetso ea transaminase e fetang makhetlo a 5 ho feta VGN,

bana ba ka tlase ho lilemo tse 18.

Ka tlhokomelo: Maloetse a CNS (ho kenyelletsa le a belaelloang ke ho kenella ha CNS) a ikemiselitseng ho ts'oaroa le ho theola monyako oa ts'ebetso ea ho ts'oaroa, bakuli ba nang le nalane ea psychosis le lefu la kelello, bakuli ba nang le maemo a proarrhythmic a joalo ka haholo basali le basali. bakuli ba tsofetseng, myasthenia gravis gravis, sebete cirrhosis, tšebeliso e kopanetsoeng le lithethefatsi tse fokotsang potasiamo.

Tšebelisano

Ha ho na tšebelisano ea bohlokoa ea moxifloxacin le atenolol, ranitidine, calcium supplements, theophylline, lithibela-pelehi tsa molomo, glibenclamide, itraconazole, digoxin, morphine, probenecid. Khalemelo ea moriana oa litekanyetso ha o kopantsoe le meriana ena ha e hlokahale.

Li-antacid, liminerale le li-multivitamine. Ts'ebeliso e tšoanang ea moxifloxacin le litokisetso tsa antacid, liminerale le li-multivitamine li ka senya ho amoheloa ha moxifloxacin ka lebaka la sebopeho sa li-chelate complexes tse nang le li-cation tsa polyvalent tse fumanehang litlhare tsena, 'me ka hona, li fokotsa mokokotlo oa moxifloxacin ka plasma ea mali. Mabapi le sena, lithethefatsi tsa antacid, antiretroviral (jk. Didanosine) le lithethefatsi tse ling tse nang le magnesium, aluminium, sucralfate, tšepe, zinki li lokela ho nkuoa bonyane lihora tse 4 pele kapa lihora tse 4 kamora ho tsamaisoa ha molomo ka moxifloxacin.

Lithethefatsi tse eketsang karohano ea QT. Kaha moxifloxacin e ama ho atolosoa ha nako ea QT, ts'ebeliso e kopaneng ea moxifloxacin le lithethefatsi tse latelang e ea tšoaetsanoa: antiarrhythmic IA (quinidine, hydroquinidine, disopyramide, jj) le III (amiodarone, sotalol, dofetilide, ibutilide, etc.licole, metabolites. phenothiazines, pimozide, sertindole, haloperidol, sultopride, jj. boikhohomoso, vincamine, bepridil, difemanil) lichelete.

Warfarin. Ha e kopantsoe le warfarin, PV le likarolo tse ling tsa coagulation ea mali ha li fetohe. Leha ho le joalo, ho bakuli ba fumanang li-anticoagulants hammoho le lithibela-mafu le moxifloxacin, ho bile le maemo a eketsehileng a ts'ebetso ea anticoagulation ea lithethefatsi tsa anticoagulant. Lintho tse kotsi li kenyelletsa boteng ba lefu le tšoaetsanoang (le ts'ebetso e amanang le ho ruruha), lilemo le boemo bo akaretsang ba mokuli. Ho sa tsotelehe taba ea hore tšebelisano pakeng tsa moxifloxacin le warfarin ha e a ka ea fumanoa, ho bakuli ba fumanang kalafo e kopaneng le lithethefatsi tsena, ho hlokahala ho lekola boleng ba INR mme, haeba ho hlokahala, ho fetola tekanyetso ea li-anticoagulants tse sa tobang.

Digoxin. Moxifloxacin le digoxin ha li ama likarolo tse ling tsa pharmacokinetic e mong le e mong. Ha o sebelisa tekanyetso ea khafetsa ea moxifloxacin C_max Digoxin e eketsehile ka hoo e ka bang 30%, ha litekanyetso tsa AUC le C_mets digoxin ha ea fetoha.

Khabone e sebetsang. Ka tšebeliso e tšoanang ea khabone e sebetsang le moxifloxacin kahare ho tekanyo ea 400 mg, systemic bioavailability ea moxifloxacin e fokotseha ka ho feta 80% ka lebaka la thibelo ea ho amoheloa ha eona.

GCS. Ka tšebeliso e tšoanang ea moxifloxacin le corticosteroids, menyetla ea ho ba le tendonitis le ripture ea tendon lia eketseha.

Tekanyetso le tsamaiso

Ka hare ho metsa ka botlalo, eseng ho hlafuna, ho noa metsi a mangata, haholo-holo ka mor'a ho ja. Se ke oa feta tekanyetso e khothalletsoang.

Se ke oa feta kalafo e khothalelitsoeng.

Ha ho phetoho ea mofuta oa kalafo ea litekanyetso e hlokahalang: ho bakuli ba tsofetseng, bakuli ba nang le ts'ebetso ea sebete e sa sebetseng (sehlopha sa A, B sethaleng sa bana-Pugh), bakuli ba nang le ts'ebetso ea renal e sa sebetseng (ho kenyelletsa le ho hloleha ho matla ha renal le "creatinine Cl" limitara / 1.73 m 2, hammoho le tse holim 'a hemodialysis e tsoelang pele le nako e telele ea orpatient peritoneal dialysis), bakuli ba merabe e fapaneng.

Bongata

Phekolo: haeba ho na le lithethefatsi tse ngata, motho o lokela ho tataisoa ke setšoantšo sa bongaka 'me a tsamaise matšoao a tšehetsang a nang le matšoao a ECG. Tsamaiso ea khabone e butsoitseng hang ka mor'a ts'ebetso ea molomo ea lithethefatsi e ka thusa ho thibela ho pepeseha hoa ts'ebetso ea moxifloxacin maemong a ho feta tekano.

Litaelo tse khethehileng

Maemong a mang, kamora tšebeliso ea pele ea lithethefatsi, hypersensitivity le allergic reaction li ka hlaha, tse lokelang ho tlaleheloa ngaka hanghang. Ke ka seoelo, ts'oaetso ea anaphylactic e ka tsoelang pele ho sokela bophelo ba lefu la anaphylactic, le kamora ts'ebeliso ea pele ea lithethefatsi. Maemong ana, kalafo e nang le Heinemox e lokela ho khaotsa mme mehato ea kalafo e hlokahalang e nkuoa (ho kenyelletsa anti-shock).

Ha o sebelisa lithethefatsi tsa Heinemox ho bakuli ba bang, ho atolosoa ha nako ea QT ho ka hlokomeleha. Ho eketsa nako ea QT ho amana le kotsi e eketsang ea ho theha li-ventricular arrhythmias, ho kenyelletsa polymorphic ventricular tachycardia. Ho na le khokahano e tobileng lipakeng tsa keketseho ea khoholeho ea moxifloxacin le keketseho ea nako ea QT. Ka lebaka leo, lethal dose le khothalletsoang (400 mg / letsatsi) ha lea lokela ho fetisoa.

Bakuli le basali ba tsofetseng ba ela hloko lithethefatsi tse eketsang nako ea QT. Ha u sebelisa lithethefatsi tsa Heinemox, menyetla ea ho ba le li-ventricular arrhythmias ho bakuli ba nang le maemo a rerang ho rera pele ho nako e ka eketseha. Mabapi le sena, Hainemox e ka se sebelisoe maemong a latelang: nako e atisang ho kenella kapa ea ho nkuoa ha nako ea QT, hypokalemia e sa hlophisitsoeng, li-bradycardia tsa bohlokoa tsa bongaka, ho nyeleha ha pelo ho tebileng ka sekhechana sa "ente" se senngoeng sa pelo, pale ea pelo le methapo e tsamaeang le matšoao a bongaka. lithethefatsi tse holisang nako ea QT (ho kenyeletsa le lithethefatsi tsa antiarrhythmic tsa sehlopha sa IA, III) le ba bang (bona "Ho kenella").

Ha o sebelisa Heinemox ea lithethefatsi, linyeoe tsa nts'etsopele ea lefu la hepatitis e phetseng hantle, li ka 'na tsa hlokomeleha. Haeba matšoao a ho hlobaela ha sebete a hlaha, o lokela ho bona ngaka pele o tsoela pele kalafo le moriana.

Ha u nka sethethefatsi sa Heinemox, ho ile ha tlalehoa linyeoe tsa nts'etsopele ea likotsi tsa letlalo la lipolao (Stevens-Johnson syndrome kapa checrolysis e nang le chefo). Mokuli o lokela ho tsebisoa hore maemong a matšoao a letlalo kapa mucous, ho hlokahala hore o buisane le ngaka pele o tsoela pele ho nka Heinemox.

Ts'ebeliso ea lithethefatsi tsa quinolone e amahanngoa le kotsi e ka bang teng ea ho ts'oaroa. Heinemox e lokela ho sebelisoa ka hloko ho bakuli ba nang le mafu a tsamaiso ea methapo e bohareng le mathata a methapo ea methapo ea kutlo e rerang ho hlaha ha ts'oaro kapa ho theola monyako oa ts'ebetso e ts'oaroang.

Heinemox e lokela ho sebelisoa ka hloko ho bakuli ba nang le myasthenia gravis. gravis mabapi le lefu le ka eketsang.

Heinemox e lokela ho sebelisoa ka hloko ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase ka lebaka la nts'etsopele ea methapo ea hemolytic.

Ts'ebeliso ea li-antimicrobials tse pharalletseng, ho kenyeletsa Heinemox, e amana le kotsi ea pseudomembranous colitis. Tlhahlobo ena e lokela ho hopoloa ho bakuli bao lets'ollo le matla le bonoang nakong ea kalafo le Heinemox. Tabeng ena, moriana o lokela ho khaotsa le kalafo e loketseng e boletsoeng. Lithethefatsi tse thibelang motility ea ka mpeng li tšoaetsanoa nts'etsopele ea lets'ollo le matla.

Ka morao ho kalafo ea quinolone, ho kenyeletsoa moxifloxacin, nts'etsopele ea tendonitis le ripture ea tendon lia khoneha, haholo ho bakuli ba tsofetseng le bakuli ba fumanang corticosteroids e tšoanang. Matšoao a pele a bohloko kapa a ho ruruha ha methapo, o lokela ho emisa ho sebelisa lithethefatsi le ho nolofatsa leoto le amehang.

Moxifloxacin ha e na phello ea sensensing, leha ho le joalo, e khothalletsoa ho qoba mahlaseli a UV nakong ea kalafo le moriana, ho kenyelletsa khanya ea letsatsi.

Tšebeliso ea moxifloxacin bakeng sa kalafo ea tšoaetso e bakoang ke lits'oants'o ha e khothalelitsoe. Staphylococcus aureuskhahlanong le methicillin (MRSA). Maemong a tšoaetso e belaelloang kapa e netefalitsoeng e bakoang ke MRSA, kalafo ka lithethefatsi tse nepahetseng tsa antibacterial e lokela ho fuoa (bona. Pharmacodynamics).

Bokhoni ba lithethefatsi Heinemox ho thibela kholo ea mycobacteria bo ka baka tšebelisano in vitro moxifloxacin ka liteko tsa Mycobacterium spp., e lebisang liphellong tse mpe tsa leshano tlhahlobisong ea mehlala ea bakuli ba tšoaroang le Heinemox nakong ena.

Ho bakuli ba kileng ba phekoloa ka li-quinolones, ho kenyeletsa Heinemox, linyeoe tsa sensory kapa sensorimotor polyneuropathy li hlalositsoe, li lebisa ho paresthesia, hypesthesia, dysesthesia, kapa bofokoli. Bakuli ba ntseng ba phekoloa ka Heinemox ba lokela ho lemosoa ka tlhoko ea ho bona ngaka hang-hang pele ba tsoela pele kalafo bakeng sa matšoao a lefu la ho ruruha, ho kenyelletsa bohloko, ho chesa, ho tsikinyeha, ho ts'oha kapa ho fokola (bona "Litla-morao").

Boitšoaro ba kelello bo ka hlaha le kamora ho khethoa ha fluoroquinolones ka lekhetlo la pele, ho kenyeletsoa moxifloxacin. Maemong a sa tloaelehang, khatello ea maikutlo kapa maikutlo a ts'ebetso ea kelello a tsoela pele menahanong ea ho ipolaea le boitšoaro ka mokhoa oa ho intša kotsi, ho kenyelletsa le liteko tsa ho ipolaea (bona "Litlamorao"). Haeba karabelo e joalo e hlaha ho bakuli, moriana oa Heinemox o lokela ho khaotsa le mehato e hlokahalang.

Ka lebaka la ts'oaetso e pharalletseng le kholo ea tšoaetso e bakoang ke chefo ea fluoroquinolone Neisseria gonorrhoeae, kalafo ea bakuli ba nang le mafu a ho ruruha ea litho tsa pelvic, moxifloxacin monotherapy ha ea lokela ho etsoa. Ntle le ha ho ba teng ha fluoroquinolone e thibelang N. gonorrhöeae qheletsoe ka thoko. Haeba ho sa khonehe ho kenyelletsa boteng ba fluoroquinolone e thibelang N. gonorrhöeae, ho hlokahala ho rarolla bothata ba ho tlatselletsa kalafo e matlafatsang ka moxifloxacin e nang le lithibela-mafu tse loketseng tse sebetsang khahlanong le N. gonorrhöeae (mohlala, cephalosporin).

Tšusumetso ho bokhoni ba ho khanna koloi le mechini e tsamaeang. Fluoroquinolones, ho kenyelletsa moxifloxacin, e ka nyenyefatsa bokhoni ba bakuli ba ho khanna koloi le ho etsa lintho tse ling tse kotsi tse hlokang tlhokomelo e eketsehileng le lebelo la karabelo ea psychomotor ka lebaka la ts'ebetso ea tsamaiso ea methapo e kholo le ho senyeha ha pono.

Moetsi

Highvlans Laboratories Pvt. Ltd. E-11, 12 & 13, Site-B, UPSIDC, Surajpur, Sebaka sa Indasteri, Greater Noida-201306, (U.P.), India.

Fono: +91 (120) 25-69-742, fax: +91 (120) 25-69-743.

imeile: [email protected], www.higlance.com

Moemeli oa moetsi ho Russia Federation: Pharma Group LLC. 125284, Moscow, st. Ho matha, 13.

Tel./fax: +7 (495) 940-33-12, 940-33-14.

Lokolla liforomo le sebopeho

Moriana oa antimicrobial o rekisoa ka mofuta oa matlapa a 400 mg ea moxifloxacin (karolo e sebetsang).

Lintho tse ling tse hlophisitsoeng:

• anhydrous colloidal silicon dioxide,
• sodium hammart
• cellulose microcrystals,
• magnesium stearate,
• peeled talcum phofo
• sodium lauryl sulfate,
• 3000 macrogol
• soya lecithin,
• oxide e khubelu
• White Opadry 85G58977.

Matšoao a ho sebelisoa

Litsela tse latelang tsa ts'oaetso le tšoaetso tse futsitsoeng ke likokoana-hloko li tsotella meriana:

• pneumonia e fumanoeng ke sechaba e halefisitsoeng ke Streptococcus anginosus le Streptococcus milleri,
• sethala se matla sa mofuta o sa foleng oa bronchitis,
• sinusitis (hlobaetsang), e halefisitsoeng ke libaktheria tsa pathogenic,
• mafu a tšoaetsanoang a ka mpeng a kenyeletsang (ho kenyeletsa le tšoaetso ea polymicrobial),
• tšoaetso ea letlalo le liso tse bobebe tsa tiske,
• maloetse a ho ruruha ha pelvic, ho kenyeletsa endometritis le salpingitis.

Heinemox e laeloa mafu a tšoaetsanoang a litho tsa kahare.
Ka tšoaetso ea letlalo, Heinemox e laetsoe.Thrombomagum ha e fuoe ho senyeha hoa tsamaiso ea phefumoloho.
Ho nwa moriana ho laetsoe pneumonia.
Ka sinusitis, ke moetlo ho fana ka Heinemox.

Mokhoa oa ho nka Heinemox

Matlapa a antimicrobial a lokela ho nooa ka molomo ka botlalo, a hlatsoe ka metsi. Ho khothalletsoa ho etsa sena kamora lijo.

• pneumonia (mofuta o fumanoeng ke sechaba): lithethefatsi li nooa ka tekanyetso ea 400 mg, kalafo e nka libeke tse 1 ho isa ho tse peli,
• bronchitis (ka ho eketsa): litekanyetso tsa letsatsi le letsatsi tsa lithethefatsi - 400 mg, nako ea tsamaiso - matsatsi a 5-10,
• sinusitis ea baktheria: 400 mg ea lithethefatsi e fanoa ka letsatsi, nako ea kalafo ke beke e le 'ngoe,
• tšoaetso ea letlalo / subcutaneous: lethal dose - 400 mg, nako ea kalafo - ho tloha libeke tse 1 ho isa ho tse tharo,
• methapo ea tšoaetso ea ka mpeng: methapo - 400 mg, nako ea kalafo - ho tloha matsatsing a 5 ho isa ho a 14,
• maqeba a ho ruruha (a sa rarahanang), a fumanehang kahara litho tsa pelvic: tloaelo e tloaelehileng ea letsatsi le letsatsi - 400 mg, nako ea tsamaiso - libeke tse 2.

Matlapa a antimicrobial a lokela ho nooa ka molomo ka botlalo, a hlatsoe ka metsi.

Phekolo ea ka mpeng

• mala a bohloko
• ho nyekeloa
• lets'ollo
• botlaela
• takatso e fokotsehileng
• stomatitis
• dysphagia
• colitis (mofuta oa pseudomembranous),
• gastroenteritis.

Nakong ea ts'ebetso ea lithethefatsi, ho ka ba le makhopho a mesifa.
Bohloko ka mpeng ke litla-morao tsa lithethefatsi Thrombomag.
Nakong ea kalafo le Heinemox, ho fokotseha ha takatso ea lijo hoa khoneha.
Moriana o ka baka lets'ollo.Ha o ntse o nka thrombomag, ho nyekeloa le pelo le ho hlatsa li ka hlaha.

Tsamaiso ea methapo e bohareng

• ho tsekela
• dysesthesia / paresthesia,
• ho senyeha ha tatso
• pherekano,
• ho hloka boroko
• khatello ea maikutlo
• vertigo
• mokhathala
• ho otsela
• Ketsahalo e makatsang
• Mathata a sebetsang ka puo,
• hypnothesia.

Ha u ntse u sebelisa lithethefatsi, ponahalo ea bofokoli bo akaretsang lia khoneha.
Ho tsitsipana ha maikutlo ho sa feleng ke litla-morao tsa ho nka Aspirin.
Ho hloka boroko ke e 'ngoe ea litlamorao tsa lithethefatsi.
Heinemox e ka baka ho otsela.

Ho tloha ka lehlakoreng la metabolism

• hyperuricemia
• sekhahla sa bilirubin,
• hyperglycemia
• Hyperlipidemia

• eosinophilia
• anaphylactic reaction,
• makhopho
• Edema ea Quincke
• laryngealimbe (e sokelang bophelo).

Mathata a utloang le dyspnea ka linako tse ling a ka hlaha.

Nakong ea kalafo le Heinemox, ho bonts'a ho se sebetse hantle hoa pelo hoa khoneha.

Tekanyo ea joala

Moetsi ha a fane ka tlhahisoleseling mabapi le motsoako o joalo.

Avelox ke analogue ea Heinemox.
Lekhetho la lithethefatsi Heinemox - Maxiflox.
Sebakeng sa Heinemox, ka linako tse ling Vigamox e laetsoe.Rotomox ka linako tse ling e fanoa ho fapana le Heinemox.

• Avelox,
• Maxiflox
• Vigamox
• Moksimak,
• Moxigram
• Aquamax
• Alvelon MF,
• Ultramox
• Simoflox,
• Rotomox,
• Plevilox,
• Moflaxia.