Protaphane® HM (Protaphane® HM)

Ho emisoa bakeng sa tsamaiso e potolohileng	1 ml
ntho e sebetsang:
insulin isophane (boenjiniere ba lefutso la motho)	100 IU (3.5 mg)
(1 IU e tsamaisana le 0,035 mg ea insulin ea motho ea nang le lerootho)
Baeti: zinc chloride, glycerin (glycerol), metacresol, phenol, sodium hydrogen phosphate dihydrate, protamine sulfate, sodium hydroxide le / kapa hydrochloric acid (bakeng sa ho lokisa pH), metsi bakeng sa ente
Botlolo e le 1 e na le 10 ml ea lithethefatsi, e lumellanang le 1000 IU

Protafan ® HM Penfill ®

Ho emisoa bakeng sa tsamaiso e potolohileng	1 ml
ntho e sebetsang:
insulin isophane (boenjiniere ba lefutso la motho)	100 IU (3.5 mg)
(1 IU e tsamaisana le 0,035 mg ea insulin ea motho ea nang le lerootho)
Baeti: zinc chloride, glycerin (glycerol), metacresol, phenol, sodium hydrogen phosphate dihydrate, protamine sulfate, sodium hydroxide le / kapa hydrochloric acid (bakeng sa ho lokisa pH), metsi bakeng sa ente
1 Penfill ® cartridge e na le 3 ml ea lithethefatsi, e lumellanang le 300 IU

Ketso ea pharmacological

E sebetsana le receptor e ikhethang ea plasma le ho kenella ka seleng, moo e buellang phosphorylation ea liprotheine tsa cellular, e tsosang glycogen synthetase, pyruvate dehydrogenase, hexokinase, inhibits adipose tisase lipase le lipoprotein lipase. Hammoho le receptor e itseng, e nolofalletsa ho kenella ha tsoekere liseleng, e ntlafatsa ho ts'oaroa ha eona ka lisele mme e khothaletsa phetoho ho glycogen. E eketsa phepelo ea mesifa ea glycogen, e matlafatsa synthes ea peptide.

Clinical Pharmacology

Phello e ba teng kamora lihora tse 1.5 kamora ho tsamaisoa ha sc, e fihla hofihlella kamora lihora tse 4 ho isa ho tse mashome a mabeli. , hammoho le li-insulin tse sebetsang ka potlako.

Tšebelisano

Phello ea hypoglycemic e ntlafatsoa ke li-acetylsalicylic acid, joala, alpha le beta blockers, amphetamine, anabolic steroids, clofibrate, cyclophosphamide, phenfluramine, fluoxetine, ifosfamide, MAO inhibitors, methyldopa, tetracycline, trifamizididi, trifamifidigidi, trifamifidigidi, trifamifidigigidi, trifamizigidi, trifamigidigidi, trifamizigidi, trifamquididi, trifamigidigidi, trifamigidigidi, trifamigidigidi, trifamizigidi, trifamquidigigidi, trifamizigidi, trifamigidigidi, trifamigidigidii, trifamizigidi. thiazides), glucocorticoids, heparin, lithibela-pelehi tsa lihormone, isoniazid, lithium carbonate, nicotinic acid, phenothiazines, sympathomimetics, li-antidepressants tsa tricyclic.

Tekanyetso le tsamaiso

Protafan ® HM Penfill ®

P / c. Setlhare sena se etselitsoe tsamaiso e tlisoang ke subcutaneous. Litšisinyeho tsa insulin li ke ke tsa kenngoa / ka.

Tekanyo ea lithethefatsi e khethoa ka bonngoe, ho nahanela litlhoko tsa mokuli. Ka tloaelo, litlhoko tsa insulin li pakeng tsa 0,3 le 1 IU / kg / letsatsi. Tlhokahalo ea insulin ea letsatsi le leng le le leng e ka ba e phahameng ho bakuli ba hanyetsang insulin (mohlala, nakong ea ho kena bohlankaneng kapa ho bakuli ba nang le botenya), le tlase ho bakuli ba nang le tlhahiso ea insulin ea insulin.

Protafan ® NM e ka sebelisoa ho monotherapy hape le motsoako o potlakileng kapa o mokhuts'oane oa insulin.

Protafan ® NM hangata e tsamaisoa ka mokhoa o potelletseng ka thipa. Haeba sena se loketse, joale liente li ka boela tsa etsoa ka leboteng la ka mpeng la mpa, karolong ea gluteal kapa karolong ea mesifa e senyehileng ea mahetla. Ka kenyelletso ea moriana ka serope, ho kenngoa butle butle ho feta ha ho kenngoa libakeng tse ling. Haeba ente e etsoa lesakeng le lelelele la letlalo, kotsi ea ts'ebetso ea ts'ebetso ea methapo ka phoso e fokotsoa.

Lenaliti le lokela ho lula le le ka tlasa letlalo bonyane metsotsoana e tšeletseng, e leng le netefatsang lethal dose. Hoa hlokahala hore kamehla o fetole sebaka sa ente kahare ho sebaka sa anatomical ho thibela nts'etsopele ea lipodystrophy.

Protafan ® NM Penfill ® e etselitsoe hore e sebelisoe ka lits'ebetso tsa ente ea Novo Nordisk insulin le li-needle tsa NovoFine ® kapa NovoTvist ®. Litlhahiso tse qaqileng tsa ts'ebeliso le ts'ebeliso ea moriana li lokela ho bonoa.

Mafu a khahlang, haholo a tšoaetsanoang le feberu, hangata a eketsa tlhoko ea mmele ea insulin. Phetoho ea mori le eona e ka hlokahala haeba mokuli a e-na le mafu a a amanang le a liphio, sebete, ho senyeha hoa sesole sa adrenal, gland ea pituitary kapa tšoelesa ea qoqotho. Tlhokahalo ea tokiso ea tekanyetso e ka hlaha le ha o fetola ts'ebetso ea 'mele kapa lijo tse tloaelehileng tsa mokuli. Ho ka hlokahala phetoho ea tekanyetso ha u fetisetsa mokuli ho tsoa mofuteng o mong oa insulin ho ea ho e 'ngoe

Bongata

Matšoao Nts'etsopele ea hypoglycemia (mofufutso o batang, palpitations, ho thothomela, tlala, ho ruruha, ho teneha, pallor, hlooho, ho otsela, ho hloka motsamao, ho bua le ho fokola hoa pono, khatello ea maikutlo). Hypoglycemia e matla e ka lebisa ho senyeha ha nakoana hoa ts'ebetso ea boko, ho akheha le lefu.

Phekolo: tharollo ea tsoekere kapa tsoekere ka hare (haeba mokuli a hlokahetse), s / c, i / m kapa iv - glucagon kapa iv - glucose.

Fomu ea tokollo

Ho emisoa bakeng sa tsamaiso ea subcutaneous, 100 IU / ml (vials). Ka botlolo ea khalase ea sehlopha sa hydrolytic 1, e koahetsoeng ka lithupa tse tsoang rabara ea brkidutyl / polyisoprene le li-cap tsa polasetiki, 10 ml ka ngoe, ka pakete ea karete ea 1 fl.

Ho emisoa bakeng sa tsamaiso ea subcutaneous, 100 IU / ml (li-cartridge). Ho 3 ml ea Penfill ® li-cartridge tsa khalase, likharafu tse 5 ka marang-rang, 1 lekhoakhoa le le leng ka pakete ea karete.