Tio-Lipon-Novopharm ea lithethefatsi: litaelo tsa tšebeliso

HoTFELISITSOE
Taelo ea Tšebeletso
tlhokomelo ea bophelo bo botle ea Ukraine
12.11.13№ 968
Setifikeiti sa ho ingolisa
№UA/13320/01/01

TLOTLISO
bakeng sa ts'ebeliso ea litlhare tsa bongaka

TIO-LIPON - NOVOFARM
(TIO-LIPON-NOVOFARM)

Moetso:
ntho e sebetsang: thioctic asiti,
1 ml ea tharollo e na le 30 mg ea thioctic (a-lipoic) acid,
baamohelang : meglumine, macrogol 300, metsi a ente.
Foromo ea litekanyetso. Tharollo ea infusion.
Sehlopha sa Pharmacotherapeutic. E bolela ho sebetsa ho ts'ebetso ea tšilo ea lijo le ho sebetsa ha metabolism. Khoutu ea PBX A 16A X 01.
Litšobotsi tsa Kliniki.
Matšoao.Thibelo le kalafo ea lefu la tsoekere la polyneuropathy, lefu la joala bo tahang, lefu la sebete (hepatitis, cirrhosis, mafura a mafura), ka ho taoa (mohlala: li-mushroom, letsoai la tšepe e boima).
Contraindication

Hypersensitivity to thioctic (α-lipoic) acid kapa ho likarolo tse ling tsa lithethefatsi,

maemo a ka lebisang ho lactic acidosis,

ho sitisoa haholo ke ts'ebetso ea liphio le sebete.

Tekanyetso le tsamaiso.Setlhare sena se fanoa ka mokhoa oa ho kenella ka hare ho sesepa ka mor'a ho ts'oaroa nakong e fetileng ka tharollo ea 0,9% ea sodium chloride.
Batho ba baholo ba khethoa hanngoe ka letsatsi 20 ml ea tharollo ho 250 ml ea tharollo ea 0,9% ea sodium chloride (e lekanang le 600 mg ea thioctic (a-lipoic) acid ka letsatsi). Maemong a boima haholo, tekanyetso ea letsatsi le letsatsi e eketsoa ho 900-1200 mg / ka letsatsi.
Tsamaiso ea methapo e etsoa butle - eseng ka potlako ho feta 50 mg ea thioctic (a-lipoic) acid (e lumellanang le 1.7 ml ea tharollo ea infusion) ka motsotso, nako ea infusion e lokela ho ba bonyane metsotso e 30.
Tharollo e lokiselitsoeng infusion e tlameha ho sebelisoa hang-hang, ha u ntse u sebelisa mekotla e sireletsang bobebe.
Lefu la tsoekere le joala bo tahang. Qalong ea thupelo, Tio-Lipon-Novofarm e tsamaisoa kahare bakeng sa libeke tse 1-2. Ka mor'a moo, ba fetohela kalafo ea tlhokomelo ka mefuta ea litekanyetso ea thioctic (a-lipoic) acid bakeng sa tsamaiso ea molomo ka tekanyetso ea 600 mg ka letsatsi.
Lefu la sebete. Lithethefatsi li fanoe ka tekanyetso ea acid e 12-2500 mg ea thioctic (a-lipoic) ka letsatsi, ho latela boholo ba boemo ba mokuli le lipontšo tsa laboratori ea boemo ba tšebetso ba sebete.
Bakeng sa prophylaxis lefu la tsoekere, polyneuropathy, ho tahoa ho sa foleng, lefu la sebete, tekanyo ea lithethefatsi e beoa ka bonngoe, ho latela: lilemo, boima ba 'mele ba mokuli le ho teba ha lefu lena. Hoa hlokahala ho qala kalafo ka tekanyetso ea pele ea 10 ml ea tharollo ka 250 ml ea tharollo ea chloride ea 0,9% (e lekanang le 300 mg ea thioctic (a-lipoic) acid ka letsatsi.
Likarabo tse fapaneng
Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa kutlo: phetoho kapa tlolo ea maikutlo a tatso, ka taolo e potlakileng, maikutlo a boima hloohong, khatello e eketsehileng ea maiketsetso, ho tuka ho chesang, mofufutso o eketsehileng, ho hema ka thata hoa khoneha. Maemong a mang, ka mor'a taolo ea methapo, hlooho ea hlooho, ho tsekela, ho tsitsipana, diplopia le ho senyeha hoa pono li ile tsa bonoa. Maemong a mangata, lipontšo tsena kaofela li feta ka botsona.
Ho tsoa tsamaisong ea mali: ho ne ho e-na le li-hemorrhages tsa petechial mucous membrane, letlalo, thrombocytopathy, dysfunction ea methapo, hypocoagulation, hemorrhagic rash (purpura), thrombophlebitis.
Ho tsoa ho tšilo ea lijo: maemong a mang, ho ile ha bonoa ka ho kenella kahare ho moriana, ho nyekeloa, ho hlatsa, lets'ollo, bohloko ba ka mpeng, bo ileng ba feta bo ikemetseng.
Ka lehlakoreng la metabolism: ka lebaka la phetoho e tsoetseng pele ea tsoekere, maemo a tsoekere ea mali a ka fokotseha, a ka bakang matšoao a hypoglycemia e ts'oanang le ho tsekela, ho fufuleloa haholo, hlooho e bohloko le ho senyeha ha mahlo.
Ho tsoa ho tsamaiso ea pelo le pelo: ka tsamaiso ea methapo e potlakileng, bohloko sebakeng sa pelo, tachycardia, e fetang ka boithatelo, e ka bonoa.
Litla-morao: sebakeng sa ente, ho hlaha ha urticaria le nts'etsopele ea eczema, petechial rashes, ho hlohlona, dermatitis, ka seoelo - systemic allergic reaction ngakhale le pele ho anaphylactic.
Boitšoaro ba lehae: ka linako tse ling - ho bakuli ba nang le hypersensitivity, maikutlo a tukang a ka hlaha sebakeng sa ente ea Tio-Lipon-Novofarm.
Bongata.Haeba ho na le lithethefatsi tse ngata, ho nyekeloa, ho hlatsa, hlooho e ka hlaha. Boemo ba ho ba le chefo ea bongaka bo ka ba teng qalong ea kalafo bo ka baka ho ferekana kelellong kapa ho ferekana ho amanang le litlamorao tse kang ho ts'oaroa ke lefu la sethoathoa ka kakaretso le nts'etsopele ea lactic acidosis. Litlhaloso tsa litlamorao tsa ho tahoa ha litekanyetso tse phahameng tsa thioctic (a-lipoic) asiti, tse kang hypoglycemia, ho tsitsipana, rhabdomyolysis, masapo a methapo ea methapo ea methapo, hemolysis, ts'ebetso ea methapo ea methapo ea methapo (DIC), thibelo ea ts'ebetso ea boko le mathata a litho tsa kahare tsa setho (ho se sebetse hantle ha litho tse ngata), li fumanoe.
Mehato ea kalafo ha motho a tahiloe.
Haeba ho na le lipelaelo tsa ho tahoa hoa bohlokoa ka thioctic (a-lipoic) acid, mokuli o lokela ho kenngoa sepetlele hang-hang mme a qale ho sebelisa mekhoa e akaretsang ea kalafo e behiloeng molemong oa chefo (e leng, ho tsosa, ho hlatsa ka mpeng, tšebeliso ea mashala a qotsitsoeng, jj.). Phekolo ea ho ts'oaroa ke sethoathoa ka kakaretso, lactic acidosis le litlamorao tse ling tse behang bophelo kotsing li lokela ho etsoa ho latela melaoana ea morao-rao ea kalafo e matla le ho latela matšoao. Ts'ebeliso ea hemodialysis, hemoperfusion le filtration mekhoa bakeng sa ho felisoa ho potlakileng ha thioctic (a-lipoic) acid ha e so ka e hlahisa melemo e kholisang.
Sebelisa nakong ea bokhachane kapa nakong ea matsoele.Ts'ebeliso ea acid ea thioctic (a-lipoic) nakong ea kemolo ha e khothalletsoe ka lebaka la khaello ea tlhaiso-leseling e hlokahalang. Ha ho na data mabapi le ho kenella ha acid ea thioctic (a-lipoic) ka lebese la matsoele, ka hona ha ho khothalletsoe ho e sebelisa nakong ea matsoele.
Bana. Tio-Lipon-Novofarm ha e khothalletsoe bana le bacha ka lebaka la khaello ea boiphihlelo ba kliniki le lithethefatsi sehlopheng sena sa bakuli.
Likarolo tsa ts'ebeliso.Molemong oa phekolo ea bakuli ba nang le lefu la tsoekere, ho laoloa khafetsa glycemic hoa hlokahala. Maemong a mang, ho hlokahala ho fetola tekanyo ea li-agents tsa hypoglycemic ho thibela hypoglycemia.
Nakong ea kalafo ea polyneuropathy, ka lebaka la lits'ebetso tse nchafatsang, keketseho ea nako e khuts'oane ea kutloelo-bohloko e ka khonahala, e tsamaisana le paresthesia ka maikutlo a "likokoanyana tse nyamelang."
Ho noella ho sa khaotseng ke sesosa sa kotsi ea polyneuropathy mme ho ka fokotsa katleho ea Tio-Lipon-Novopharm. Ka hona, ho khothalletsoa ho hana ho noa joala nakong ea kalafo le moriana. Tio-Lipon-Novofarm ha ea lokela ho beoa ka nako e ts'oanang le litokisetso tse nang le tšepe (litokisetso tsa tšepe, magnesium, calcium), hammoho le lihlahisoa tsa lebese tse nang le calcium.
Setlhare sena se na le mathata, ka hona, libotlolo li lokela ho tlosoa sephutheloaneng hang feela pele li sebelisoa.
Litharollo tsa infusion li lokela ho sireletsoa ke letsatsi ka ho li koahela ka mekotla e sireletsang khanya. Tlas'a maemo ana, tharollo ea infusion e lokiselitsoeng e lula e loketse lihora tse 6.
Bokhoni ba ho susumetsa sekhahla sa karabelo ha u khanna kapa u sebetsa ka mekhoa e meng. Setlhare ha se ame boemo ba karabelo nakong ea ho khanna kapa ho sebetsa ka mekhoa e meng, empa ha ho bonahala matšoao a litla-morao tsa lithethefatsi (bona "lits'oants'o tse fapaneng"), hoa hlokahala ho hana mofuta ona oa ketsahalo.
Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano. Asiti ea Thioctic (a-lipoic) e kopana le li-ionic irones complexes (mohlala, chisplatin), kahoo lithethefatsi li ka fokotsa phello ea sisplatin.
Ka limolek'hule tsa tsoekere (ka mohlala, le tharollo ea levulose), acid ea thioctic (a-lipoic) e hlahisa metsoako e mengata e rarahaneng e qhibilihang.
Thioctic (a-lipoic) asiti ke chelator ea tšepe, ka hona e ke ke ea sebelisoa hammoho le tšepe (tšepe, litokisetso tsa magnesium).
Asiti ea Thioctic (a-lipoic) e ka ntlafatsa phello e fokotsang tsoekere ea insulin le / kapa lithethefatsi tse ling tsa antidiabetes, ka hona, haholo-holo qalong ea kalafo ka thioctic (a-lipoic) acid, ho hlahlojoa khafetsa maemo a tsoekere ea mali ho bontšitsoe. Ho thibela ho qaleha ha matšoao a hypoglycemia maemong a mang, ho ka 'na ha hlokahala hore u theole tekanyetso ea insulin le / kapa moemeli oa antidiabetesic ea molomo.
Melemo ea pharmacological.
Pharadodynamics Thioctic (a-lipoic) asiti ke ntho e hlophisitsoeng 'meleng mme e bapala karolo ea coenzyme ka har'a oxidative decarboxylation ea acid-keto, e bapala karolo ea bohlokoa ts'ebetsong ea matla a ho etsa sele ka seleng. E thusa ho fokotsa tsoekere ea mali le ho eketsa bongata ba glycogen bokong. Ho haella kapa metabolism e senyehileng ea thioctic (a-lipoic) asiti ka lebaka la tahi kapa ho bokella ka bongata lihlahisoa tse itseng tse bolileng (mohlala, 'mele oa ketone) ho lebisa ho sitisoeng ha aerobic glycolysis. Asiti ea Thioctic (a-lipoic) e ka ba teng ka mefuta e 'meli e sebetsang ea' mele (e nang le oxidized le e fokotsehileng) ka litlamorao tsa antitoxic le antioxidant. Asiti ea Thioctic (a-lipoic) e ama metabolism ea cholesterol, e nka karolo taolong ea metabolism ea lipid le carbohydrate, e ntlafatsa ts'ebetso ea sebete (ka lebaka la hepatoprotective, antioxidant, detoxification). Thioctic (a-lipoic) asiti e tšoana maemong a meriana le livithamini tsa B.
Mofumahali Asiti ea Thioctic (a-lipoic) e ba le liphetoho tse ngata nakong ea ha e qala ho fetela ka har'a sebete. Ho fokotseha ho hoholo ha lintho tse kopantsoeng molemong oa ho ba teng hoa acid ea thioctic (a-lipoic) hoa utloahala. E hloekisoa ke liphio haholo ka mokhoa oa metabolites. Ho thehoa ha metabolites ho etsahala ka lebaka la oxidation ea lehlakore le thipa. Bophelo ba halofo ea thioctic (a-lipoic) acid e tsoang serum ea mali ke metsotso e 10-20.
Litšoaneleho tsa meriana.
Mefuta ea mantlha ea 'mele le ea lik'hemik'hale: tharollo e hlakileng ea 'mala o mosehla kapa o moputsoa.
Ho se lumellane. Tharollo ea thioctic (a-lipoic) asiti ha e lumellane le tharollo ea glucose, tharollo ea Ringer le tharollo e ka arabelang ka lihlopha tsa SH-group kapa li-dissuffide bond.
Letsatsi la ho felloa ke nako. Lilemo tse 2
Maemo a polokelo. Boloka ka har'a sephutheloana sa mantlha ka mocheso o sa feteng 25 ° C. Qoba hole le bana.
Ka lebaka la hore acid ea thioctic (a-lipoic) e tsotella leseli, lipilara li tlameha ho bolokoa ka paketeng ea karete ho fihlela li sebelisoa kapele.
Ho paka. 10 ml kapa 20 ml ka libotlolong, libotlolo tse 5 tsa polasetiki ea blister, 1 kapa 2 blist strip ka lebokoseng la karete.
Mokhahlelo oa phomolo. Ka lengolo la ngaka.
Moetsi Khampani ea LLC "Novopharm-Biosynthesis".
Sebaka. Ukraine, 11700, tikoloho ea Zhytomyr, Novograd-Volynsky, st. Zhytomyr, 38.
Letsatsi la ntlafatso la ho qetela.

Sposib zastosuvannya that dozi

Setlhare se fanoa ka phatleng ea tšelo ea methapo ea kahare ea infusion ea 0,9% ea sodium chloride.

Doroslim e bolela nako e le 'ngoe ka dob 20 ml, motso ho 250 ml ea 0,9% rosin sodium chloride (e lekanang le 600 mg ea acid (a-lipo) acid ho dob). Ho arc ea linoha tse matla, ke tla eketsa lethal dose ho fihlela ho 900-1200 mg / dob.

Ho tsamaisa kahare ho feta eseng ka tlase ho 50 mg ea acid (a-lipoic acid) (e leng 1,7 ml ea theko ea infusion) bakeng sa palo ea chelete, litšenyehelo tsa infusion ha li tlase ho makhetlo a 30.

Litokisetso tsa infusion ea rozschin slid ha li amoheloe ka mokhoa o sa reroang ka tsela, ka liphutheloana tsohle tse hlōlang.

Lefu la tsoekere le joala bo tahang. Holiming, tseleng ea Lіkuvannya Tіo-Lіpon-Novofarm zatosovyut kahare ho otlolla ka hare 1-2 tizhnіv. Nadal e lokela ho fetohela pidtrimuyuyu kalafo ka mefuta ea lіkarskimi tіoktovoi (a-lіpopovo) acid le bakeng sa tsamaiso ea molomo ka tekanyo ea 600 mg ka ho fetisisa ka Dob.

Ho ts'oaroa ha setofo. Setlhare se fanoe ka tekanyo ea 600-1200 mg ea acid (a-lipoic acid) bakeng sa kalafo e tlatselletsang, mokuli o kula haholo, mme ho na le lipontšo tsa laboratori le tsa laboratori tsa kampa e sebetsang ea sebete.

Bakeng sa prophylaxis Lefu la tsoekere la polyneuropathy, ho tahoa ho sa foleng, bokuli ba sebete, lethal dose e lokela ho fetoloa ho moriana ka o mong, ho sa tsotelehe mofuta: bokuli, boima le boima ba maemo a boima. Lokisa tlhoko ea tekanyetso ea cob ea 10 ml bakeng sa 250 ml 0,9% ea sodium chloride (e lekanang le 300 mg ea acid (a-lipoic acid).

Boitšoaro

Ho tloha lehlakoreng la tsamaiso ea methapo le setho seo ka botebo: Zmina abo a otla smakovyh vidchuttіv, a na le lehlabatheho lihlahisoa tsa vlvdchuttya hloohong, pidvyshennya ka hare torsion grip, leqhubu, pidvisthennuyu pitlivist, mathata a ho hema. Tabeng ea ho oa ho hoholo, hlooho e ka hare, ho koala, Judomis, diplopia, zora e senyehileng e ile ea bakoa. Eba le li-vipadkiv us_kazan_ tse fetang ka tsona.

Ho tloha lehlakoreng la tsamaiso ea mali: petechial hemorrhages ho li-membrane tsa mucous, letlalo, thrombocytopathy, ts'ebetso ea thrombocyte e fokolang, hypocoagulation, hemorrhagic visipa (pherese), thrombophlebitis fueled.

Ho tloha lehlakoreng la tsela ea joang: ho okremich vipadka, ka moriana o ka hare oa shvidkoy, ho nyekeloa, moea, lets'ollo, bohloko ba ka mpeng, le yelp li ile tsa fetisoa ka bohona.

3 side obmіnu rechovin: ka lebaka la ho eketsoa ha tsoekere e ngata, re ka fokotsa tsoekere e maling maling, ka ho eona re ka utloa matšoao a matšoao, a kang ho koaloa, mocheso o eketsehileng, hlooho e opang le serame.

Ho tloha lehlakoreng la sistimi ea ho tsamaisa pelo: ka tlhahiso ea shvidku e kahare, o ka tseba ho potlaka ka pelong, tachycardia, empa e ikemetse.

Karabelo: khoeling e fetileng, re ka hapa mahlaseli a selemo le hoetla le selemo, petroleum, dermatitis, dermatitis, and systemic allergic reaction to anaphylactic shock.

Likarabo: Inodi - ho mokuli ea nang le sensitivity ea utloisisang nako e ngata, Lonu-Novofarm e kanna ea ba matla le ho feta.

Ho feta tekano

Haeba ho na le bongoana bo bongata, ho betsa ho hlonama, ho phunya, hlooho. Bohlokoa ba ts'oaetso ea chefo e ka ba bohlasong ba ho tšoenyeha ha maikutlo a psychic, empa tlhoko ea ho kenella kalafong e joalo, joalo ka ho ts'oaroa ka kakaretso le nts'etsopele ea lactic acidosis. Buli otrimanі inventory joalo іntoksikatsіynih naslіdkіv tekanyetso sebeletsa tempeleng tіoktovoї (a-lіpoєvoї) acid e gіpoglіkemіya Yak, makala, rabdomіolіz, GOSTR necrosis ya marapo m'yazіv, gemolіz, disemіnovane vnutrіshnosudinne zgortannya (FEP), prignіchennya funktsії hlooho mozk hore rozladi vnutrіshnіh organіv (multiorganna nedostatnіst )

Pheko e kene ho Intoxication.

Haeba ho na le kotsi e kholo ea ho ba chefo, mokuli o hloka ho kena sepetlele lapeng kaofela, mme ho hlokahala hore a ba qhetse ka thoko tlhokahalo ea ho itlhokomela.Ka mokhoa o ts'oanang, ho ts'oaroa ka kakaretso, lactic acidosis le tahi e atileng, e ka sokelang bophelo, e lokela ho etsoa ntle ho tšenyo ea nako ho fihlela ho hlahisoa letšoao la bohlokoahali. Nts'etsopele ea hemodialysis, hemoperfusion le filtration mekhoa ea ho potlakisa ts'ebetso ea acid (a-lipoic acid) le dosi ha ea tlisa mosebetsi o mongata.

Zastosuvannya nakong ea bokhachane vag_nostnost abo selemovannya

Nako ea acid (a-lipo) acid le hora ea tšebetso ha e khothalletsoe ka ho fumaneha ha tlhaiso-leseling ea molao. Sedanishe mabapi le ho kenella ha acid (a-lipo) acid matsoeleng, lebese ha le tsebe letho, e le hore sefuba sa sefuba selemong sa pele ha se khothalletsoe.

Tio-Lіpon-Novofarm ha e khothalletsoe ho tsoala bana ka ho fumaneha ha liteko tsa tliliniki bakeng sa ho hlophisoa ha sehlopha se fanoeng sa bakuli.

E na le zastosuvannya

Tabeng ea bokuli ba lefu la tsoekere la chukrovia, taolo e hlokahalang ea karolo ke glikemії. Tabeng ea ho oa ho hoholo, ho hlokahala hore o fetole litekanyetso tsa lietsahala tse kotsing e tlase ka sepheo sa ho fumana gogoglіkemії.

Bakeng sa halofo ea hora ea polieneuropathy, lits'ebetso tse ngata tse nchafatsang, kutloelo-bohloko e atisang ho feta, ke kopa ho beha leihlo makhetlo a 'maloa ka "goosebump".

Ho noesa joala ka potlako ke sesosa sa ho phahama ha polyneuropathy mme ho ka fokotsa katleho ea Tio-Lippon-Novopharm. Ho khothalletsoa hore u hlokomele joala le ho noa joala ka hora. Eseng hang-hang ho saena Tio-Lіpon-Novofarm hang-hang ka lithethefatsi, tse hlokahalang ho nka tšepe (ho lokisa zaliza, magnesium, calcium), empa le lihlahisoa tsa lebese tse hlokahalang ho nka calcium.

Setlhare se na le kutloelo-bohloko, ke botlolo ea ho jara tilka ntle le tšenyo kapele ho ba atlehang.

ІІфу зІ to to ho nka mefuta eohle ea leseli le robetseng ka thuso ea liphutheloana tse ikemetseng. Ka mehopolo ena ea litokisetso, motsoako oa rozchin o tla lahleha ka letsatsi le latelang ho feta lilemo tse 6.

Vz зmodiya le іnshimi lіkarskimi bonaba hore іnshі vidi vzakmodiiy

Tioktova (a-lіpoєva) asiti e sebetsa hape ka li-complexes feela tsa tšepe (mohlala, ka lisplatin), kahoo lithethefatsi li ka fokotsa phello ea lisplatin.

Ka limolek'hule tsa likomkomere (mohlala, ka sesosa sa levulose) th_oktova (a-lіpoєva) asiti ke tla tiisa bohlokoa bo amanang le li-spoluki tse rarahaneng.

Tioktova (a-lіpoпva) asiti ke chelator ea tšepe, ka hona, ho ke ke ha khoneha ho tsitsisa tšepe ka nako e le ngoe (litokisetso zaliza, magnіyu).

Tioktova (a-lipo) asiti e ka fuoa phello e ntle ea insulin le / kapa mafu a tlase a protibiotic, haholo-holo ho cob ea i-uric acid (a-lipo) tlhahlobo ea khafetsa, matšoao. Bakeng sa melemo ea matšoao a hypoglycaemia ho okimich vipads, o ka hloka ho ba le lethalinyana le tlase la antidiabetic ea molomo le molomo.

Litsebi tsa meriana

Pharadodynamics. Tioktova acid (a-lіpoєva) ke acid ов cystic acid, e hlophisitsoeng 'meleng le karolo ea coenzyme ka har'a oxidative decarboxylation ea acid-keto acid, mme karolo ea coenzyme e bohlokoa ts'ebetsong ea ho fana ka matla ho mokuli. Ho fafatsa phetoho ea tsoekere ea mali maling le ho eketseha ha tsoekere ea mali maling. Ho sitoa ho fokotsa bongata ba asiti (a-lipo) le lintho tse nang le chefo hammoho le ho bokella lihlahisoa tse ngata ka thomello (mohlala, mefuta ea ketone) ho lebisa ho timeng ha aerobic glycol. Tіoktova (a-lіpoєva) asiti e ka fumaneha ka mefuta e 'meli e sebetsang ea' mele (e nang le oxidized le e nchafalitsoeng), e bitsoang antitoxic le antioxidant. Tioktova (a-lipoic) asene e kenngoa ka har'a phapanyetsano ea cholesterol, hlokomela metabolism e tloaelehileng ea lipid le carbohydrate, ts'ebetso ea polyphenol ea sebete (hepatoprotective, antioxidant, antioxidant function). Tіoktova (a-lіpoєva) asiti e loketse ba boholong ho tsa meriana le sehlopha sa V.

Mofumahali. Tіoktova (a-lіpoєva) asiti e tsejoa e le ea bohlokoa haholo nakong ea karolo ea pele ka seboping. Ho potlakisa bohlokoa ba bongata bo bongata tsamaisong ea ho fumaneha ha acid (a-lipo) acid. Ho boima haholo ho fumana li-nirkas ho metabolism ea viglyad. Metabolism e amohetsoeng ka lebaka la oxidation ea lance ea morao le kopane. Nako eo ka eona acid (a-lipo) acid le sirapo ea mali e bang 10-20 hvilin.

Umovi zberigannya

Zberigati ka har'a polasetiki ea pele ka mocheso oa 25 ° С. Zberigati ha e khonehe ho bana.

Ho zvіyazku zim, scho tіoktova (a-lіpoєva) asiti e tsotella dііv svіtla, vials іlіd zberіgati іn carton e pakela li-tо tse sa tsitsang.

10ml kapa 20 ml ka vial e le ngoe, lipompo tse 5 ka sehokelo sa terata e le ngoe, tse 1 ho tsetelloa ka polasetiki ka lebokoseng la karete.

Sokolla foromo le sebopeho

Mefuta ea litekanyetso tsa thiolipone e lokolloang:

Matlapa a koahetsoeng ka filimi: khetla e 'mala o mosehla kapa o mosehla o bosehla bo botala,' mala oa botala o bobebe, 300 mg e 'ngoe le e' ngoe e pota-potile, biconvex, 600 mg e ngoe le e ngoe e ka lehlakoreng le leng, ka lehlakoreng le leng le nang le notch (ka lebokoseng la karete e 1 ea khalase e lefifi sekotlolo sa litafole tse 30 kapa tse 50, ka lebokoseng la mekotla e meraro ea li-1-3, ka paketeng ea li-pcs tse 10.),
tsepamisa maikutlo ha ho etsoa tharollo ea tharollo ea methapo: e pepeneneng, e botala bo bosehla (ka har'a karete e tšetseng li-ampoule tse 10 kapa lipakete tse 1 tsa li-ampoules tse 5).

Phetolo e le 'ngoe ea tafole e le' ngoe ea thiolipone:

ntho e sebetsang: thioctic acid (lipoic acid) - 300 kapa 600 mg,
likarolo tse thusang (300/600 mg): calcium stearate monohydrate - 5 / 8,2 mg, lactose monohydrate (tsoekere ea lebese) - 91.5 / 80.6 mg, sodium stearyl fumarate - 5 / 8.2 mg, hypromellose - 5 / 8,2 mg, sodium carboxymethyl starch (primogel) - 17.5 / 28.7 mg, colloidal silicon dioxide - 7.5 / 12.3 mg, cellcosestalline cellulose - 50/41 mg, magnesium stearate - 5 / 8.2 mg magnesium hydrosilicate - 13.5 / 24.6 mg,
khetla (300/600 mg): Opadry II (hypromellose - 3.4 / 4.1 mg, macrogol 4000 –1.1 / 1,3 mg, lactose monohydrate - 3 / 3.6 mg) - 10/12 mg, mebala ea 'mala - 2,5 / 3 mg, titanium dioxide (E 171) - 2 / 2.4 mg, varnish ea aluminium e thehiloeng holima quinoline (E 104) - 0,4 / 0,48 mg, alarnum varnish e thehiloeng ho indigo carmine ( E 132) - 0,05 / 0,06 mg, aluminium varnish e thehiloeng mohloling o mosehla oa letsatsi (E 110) - 0,05 / 0,06 mg.

Complication ea 1 ml Tiolipon tsepamisa maikutlo:

ntho e sebetsang: thioctic acid (lipoic acid) - 30 mg,
likarolo tse thusang: propylene glycol, ethylene diamine, metsi a ente.

Pharadodynamics

Thioctic acid (alpha-lipoic acid) ke antioxidant ea endo native (e kopanyang li-radicals tsa mahala), e thehoa 'meleng nakong ea oxidative decarboxylation ea alpha-keto acid.

E na le hypolipidemic, hepatoprotective, hypoglycemic le hypocholesterolemic effect.

Joalo ka coenzyme ea mitochondrial multenzyme complexes, e nka karolo ea oxidative decarboxylation ea alpha-keto acid le pyruvic acid. E kenya letsoho ho eketseha ha glycogen ho sebete le ho fokotseha ha khatello ea tsoekere maling le hammoho le ho hlola insulin.

Ka mofuta oa ts'ebetso ea biochemical, lipoic acid e haufi le livithamini tsa B. E hlokahala bakeng sa metabolism ea carbohydrate le lipid, e tsosa metabolism ea cholesterol, e ntlafatsa ts'ebetso ea sebete le tropic neurons.

Mofumahali

Tsamaiso ea methapo: C_max (boholo ba mahloriso) ke 0.025-0.038 mg / ml, nako ea ho e fihlela ke metsotso e 10-11, sebaka se katlasa nako ea nako ea mahloriso ke hoo e ka bang 0.005 mg / ml,
Tsamaiso ea molomo: lipoic acid e amoheloa ka botlalo 'me e kenella ka potlako mokhoeng oa mpa, ha ho nkoa hoa mali ha ho ntse ho nooa moriana ka lijo. Nako ea ho fihlela khatello e phahameng e tsoa ho metsotso e 40 ho isa ho e 60.

Bioavailability ke 30%. Lipoic acid e na le "phello ea pele" ka har'a sebete. Ka lebaka la oxidation ea lehlakore le enjine, ho etsoa ha metabolites ho etsahala.

Bophahamo ba thomello ke hoo e ka bang 450 ml / kg. Thioctic acid le metabolites ea eona li hlahisoa ke liphio (80-90%). Ho felisoa ha halofo ea bophelo ho etsa metsotso e 20-50. Tlhahiso ea plasma ka botlalo ke 10-15 ml / min.

Contraindication

khaello ea lactase, ho se mamelle lactose, glucose-galactose malabsorption (matlapa),
ho ima le ho nyeka,
lilemo tse 18
ho se mamelle setho ka seng sa karolo ea lithethefatsi.

Setsoalle (thiolipone se laetsoe tlasa taolo ea ngaka):

lefu la tsoekere (matlapa),
lithethefatsi tse sa foleng (matlapa).

Litaelo tsa ho sebelisa Thiolipone: mokhoa le litekanyetso

Thiolipone e nooa ka molomo ka metsi a fokolang, ntle le ho hlafuna.

Matlapa a nooa hang ka letsatsi ka mpeng e se nang letho, metsotso e ka bang 30 pele ho lijo tsa pele.

Sekhahla sa letsatsi le letsatsi ke 600 mg.

Nako e fokolang ea thupelo ke likhoeli tse 3 (maemong a mang, ho ka hlokahala kalafo e telele).

Tharollo ea ente

Thiolipon e tsamaisoa ka matla. Pejana, ho tsepamisa mohopolo ho lokela ho kenngoa ka tharollo ea isotonic sodium chloride.

Mefuteng e matla ea lefu lena, 300-600 mg e tsamaisoa hang ka letsatsi ka mokhoa oa infravenous drip infusion (ka metsotso e 50).

Nako ea ts'ebeliso e tsoa libeke tse peli ho isa ho tse 'ne. Kamora ho fela ha nako ena, mokuli o fetisetsoa tšebetsong ea molomo oa lithethefatsi (300-600 mg ka letsatsi) ka likhoeli tse tharo.

Litlamorao

Litla-morao tse ka 'nang tsa hlaha: hypoglycemia (e amanang le ho ts'oaroa ha tsoekere e ntlafalitsoeng), maemo a ho kula (ho kenyeletsa urticaria, anaphylactic shock).

Litlolo tse ling tse ka etsahalang:

lipilisi: dyspepsia, ho kenyelletsa ho nyekeloa, ho hlatsa, ho opeloa ke pelo,
Tharollo ea ente: ka seoelo - ho thothomela, diplopia, hemorrhages letlalong le li-membrous tsa mucous, thrombocytopathy, hemorrhagic rash, thrombophlebitis, le tsamaiso e potlakileng ea tharollo - khatello e eketsehileng ea intracranial (ponahalo ea boima bo boholo hloohong), ho hema ka thata (kalafo e eketsehileng ha e hlokehe).

Litaelo tse khethehileng

Bakuli ba nang le lefu la tsoekere ba hloka ho hlahlojoa khafetsa ka tsoekere ea mali, haholo-holo methating ea pele ea moriana. Maemong a mang, ngaka e ka fokotsa tekanyetso ea lithethefatsi tsa insulin / molomo ka molomo ho thibela hypoglycemia.

Nakong ea kalafo, o lokela ho hana ho nwa joala, hobane ka nako e ts'oanang ho na le bofokoli ba phello ea kalafo ea thioctic acid.

Li-ampoules tse nang le mohopolo li tlameha ho tlosoa ho tloha hang hang ka pele ho ts'ebeliso, e amanang le foto ea ntho e sebetsang. Nakong ea infusion, ho bohlokoa ho sireletsa botlolo ea tharollo ho tloha leseli (ho ka khoneha ho sebelisa mekotla e sireletsang bobebe, foil ea aluminium). Nako e phahameng ea ho boloka tharollo e lokisitsoeng ke lihora tse 6.

Ho sebelisana le lithethefatsi

cisplatin: ho fokotseha ha ts'ebetso ea eona (cisplatin e khothalletsoa ho nkoa ka mor'a lijo tsa motšeare kapa mantsiboea),
Litokisetso tsa magnesium / iron, hammoho le lihlahisoa tsa lebese ka lebaka la khalsiamo e ho tsona: kaha thioctic acid e kopana le li-complexion tsa tšepe tsa ionic, nako e khothalelitsoeng ea tšebeliso ea lithethefatsi tsena e ka ba thapama kapa ka shoalane.
joala (ethanol): ho fokotseha hoa ts'ebetso ea bongaka ea Thiolipon,
li-insulin le li-agent tsa hypoglycemic tsa molomo: ho matlafatsa ketso ea bona.

Mokhoa oa kopo

Lithethefatsi Thiolipone e etselitsoe ho hlophisoa ha tharollo ea infusion kamora ho qala ho hlatsoa tharollo ea isotonic sodium chloride.
Mefuteng e matla ea lefu la tsoekere kapa lino tse nang le tahi, 300-600 mg 1 nako ka letsatsi e lokela ho fanoa e le infusion e kenang ea lerapo. Ho kenella ka hare ho mpa ho lokela ho tsamaisoa pele ho feta metsotso e 50.
Setlhare se khothalletsoa hore se sebelisoe nakong ea libeke tse 2 ho isa ho tse peli.
Ebe o ka tsoela pele ho sebelisa moriana o kahare ka tekanyetso ea 300-600 mg ka letsatsi. Nako e fokolang ea kalafo ka matlapa ke likhoeli tse 3.

Ho sebelisana le lithethefatsi tse ling

Alpha - lipoic acid (e le tharollo ea infusion) e fokotsa phello ea cosplatin. Ka tšebeliso e tšoanang le insulin le li-agents tse ling tsa hypoglycemic ea molomo, keketseho ea phello ea hypoglycemic e bonoa. Alpha-lipoic acid e etsa metsoako e rarahaneng e bonolo ea metsoako ea limolek'hule (mohlala, tharollo ea levulose), ka hona, ha e lumellane le tharollo ea glucose, tharollo ea Ringer, hammoho le likhomphutha (ho kenyelletsa le tharollo ea tsona) tse arabelang ka di-disulfide le lihlopha tsa SH. .

Sehlopha sa mahlale

Mekhoa e amang ts'ebetso ea tšilo ea lijo le lits'ebetso tsa metabolic. Khoutu ea ATS 16A X 01.

Thibelo le kalafo ea lefu la tsoekere la polyneuropathy, methapo ea joala, mafu a sebete (hepatitis, cirrhosis, mafura a mafura), ka ho taoa (mohlala, li-mushroom, letsoai la tšepe e boima).

Karabelo e mpe

Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa kutlo: phetoho kapa tlolo ea maikutlo a tatso, ka taolo e potlakileng, maikutlo a boima hloohong, khatello e eketsehileng ea maiketsetso, ho tuka ho chesang, mofufutso o eketsehileng, ho hema ka thata hoa khoneha. Maemong a mang, kamora ho busa, ho opeloa ke hlooho, ho tsekela, ho tsitsipana, diplopia le ho senyeha hoa pono li ile tsa bonoa. Maemong a mangata, lipontšo tsena kaofela li feta ka botsona.

Lehlakore la mali: ho ne ho e-na le li-hemorrhages tsa petechial mucous membrane, letlalo, thrombocytopathy, ts'ebetso ea mokokotlo oa mokokotlo, hypocoagulation, hemorrhagic rash (purpura), thrombophlebitis.

Ho tsoa ho tšilo ea lijo: maemong a mang, ka ts'ebetso e potlakileng ea lithethefatsi, ho nyekeloa, ho hlatsa, lets'ollo, bohloko ba ka mpeng, bo ileng ba feta bo ikemetseng.

Mahlakore a 3 a metabolism: ka lebaka la ts'ebetso ea tsoekere e ntlafalitsoeng, maemo a tsoekere ea mali a ka fokotseha, a ka bakang matšoao a hypoglycemia e ts'oanang, joalo ka ho tsekela, ho fufuleloa haholo, hlooho e bohloko le ho ferekana ha pono.

Ho tsoa ho tsamaiso ea pelo le pelo: ka tsamaiso e potlakileng, bohloko sebakeng sa pelo, tachycardia e ka hlaha, ea feta ka bohona.

Litla-morao : sebakeng sa ente, ho hlaha ha urticaria le ho ruruha ha eczema, petechial rash, ho hlohlona, dermatitis, ka seoelo - systemic allergic reaction ngakhale le pele ho anaphylactic.

Boitšoaro ba lehae: ka linako tse ling - bakuli ba nang le hypersensitivity sebakeng sa ente ea Tio-Lipon-Novofarm ba ka ba le maikutlo a tukang.

Bongata

Haeba ho na le lithethefatsi tse ngata, ho nyekeloa, ho hlatsa, hlooho e ka hlaha. Boemo ba ho ba le chefo ea bongaka qalong ea kalafo bo baka ho ruruha ha psychomotor kapa ho fifala ha khoeli 'me hangata bo amana le litlamorao tse kang ho ts'oaroa ka kakaretso le nts'etsopele ea lactic acidosis.

Mehato ea kalafo ha motho a tahiloe.

Haeba ho na le lipelaelo tsa ho tahoa hoa bohlokoa ka thioctic (a-lipoic) acid, mokuli o lokela ho kenngoa sepetlele hang-hang mme a qale ho nka mehato e akaretsang ea kalafo e laetsoeng ke chefo (e leng, ho tsosa, ho hlatsuoa ka mpa, tšebeliso ea mashala a qotsitsoeng, jj.). Phekolo ea ho ts'oaroa ke sethoathoa ka kakaretso, lactic acidosis le litlamorao tse ling tse behang bophelo kotsing li lokela ho etsoa ho latela melaoana ea morao-rao ea kalafo e matla le ho latela matšoao. Ts'ebeliso ea hemodialysis, hemoperfusion le filtration mekhoa bakeng sa ho khaotsa ho potlakisa ha thioctic (a-lipoic) acid ha e e-so ka e tlisa melemo e kholisang.

Sebelisa nakong ea bokhachane le pelehi

Ts'ebeliso ea acid ea thioctic (a-lipoic) nakong ea kemolo ha e khothalletsoe ka lebaka la khaello ea tlhaiso-leseling e hlokahalang. Ha ho na data mabapi le ho kenella ha acid ea thioctic (a-lipoic) ka lebese la matsoele, ka hona ha ho khothalletsoe ho e sebelisa nakong ea matsoele.

Tio-lipon-Novofarm ha e khothalletsoe ho bana le bacha ka lebaka la khaello ea boiphihlelo ba kliniki le lithethefatsi sehlopheng sena sa bakuli.

Likarolo tsa ts'ebeliso

Molemong oa phekolo ea bakuli ba nang le lefu la tsoekere, ho laoloa khafetsa glycemic hoa hlokahala. Maemong a mang, ho hlokahala ho fetola tekanyo ea li-agents tsa hypoglycemic ho thibela hypoglycemia.

Nakong ea kalafo ea polyneuropathy, ka lebaka la mekhoa e ntlafalitsoeng, keketseho ea nakoana ea maikutlo e ka khonahala, e tsamaisana le paresthesia e nang le maikutlo a "ho akheha."

Ho noella ho sa khaotseng ke sesosa sa kotsi ea polyneuropathy mme ho ka fokotsa ts'ebetso ea Tio-lipon-Novopharm.

Setlhare se na le khatello ea maikutlo, kahoo linoko li lokela ho tlosoa sephutheloaneng hang feela pele li sebelisoa.

Litharollo tsa infusion li lokela ho sireletsoa ke letsatsi ka ho li koahela ka mekotla e sireletsang khanya. Tlas'a maemo ana, tharollo ea infusion e lokiselitsoeng e lula e loketse boholo ba 6:00.

Melemo ea pharmacological

Pharadodynamics Thioctic (a-lipoic) asiti ke ntho e hlophisitsoeng 'meleng mme e bapala karolo ea coenzyme ka har'a oxidative decarboxylation ea a-keto acid, e bapala karolo ea bohlokoa ts'ebetsong ea matla a ho etsoa ka seleng.

Mofumahali Asiti ea Thioctic (a-lipoic) e ba le liphetoho tse ngata nakong ea ha e qala ho fetela ka har'a sebete. Ho fokotseha ho hoholo ha lintho tse kopantsoeng molemong oa ho ba teng hoa acid ea thioctic (a-lipoic) hoa utloahala. E hloekisoa ke liphio haholo ka mokhoa oa metabolites. Ho thehoa ha metabolites ho etsahala ka lebaka la oxidation ea lehlakore le thipa. Bophelo ba halofo ea thioctic (a-lipoic) acid e tsoang serum ea mali ke metsotso e 10-20.

Maemo a polokelo

Boloka ka har'a sephutheloana sa mantlha ka mocheso o sa feteng 25 ° C. Qoba hole le bana.

Ka lebaka la hore acid ea thioctic (a-lipoic) e ela hloko ketso ea khanya, libotlolo li lokela ho bolokoa ka har'a liphatlalatso tsa karete ho fihlela li sebelisoa kapele.

10ml kapa 20 ml ka libotlolong, libotlolo tse 5 tsa polasetiki ea blister, 1 kapa 2 blister lipakete tsa karete.