Lefu la tsoekere

Mekhoa ea ho fumana hyperglycemia ea transit e kenyelletsa boikemisetso ba liprotheine tsa glycosylated, nako ea ho ba teng ha eona 'meleng e simollang libeke tse peli ho isa ho tse 12. Ho ikopanya le glucose, ba e bokella, ka mokhoa oa mofuta oa sesebelisoa sa memori se bolokang tlhahisoleseling mabapi le boemo ba glucose maling ("Memory glucose ea mali"). Hemoglobin A bathong ba phetseng hantle e na le karoloana e nyane ea hemoglobin A1c, e kenyeletsang tsoekere. Peresente ea hemoglobin ea glycosylated (HbA1c) ke 4-6% ea palo eohle ea hemoglobin.

Ho bakuli ba nang le lefu la tsoekere mellitus ba nang le hyperglycemia e sa feleng le mamello ea tsoekere e theolehang (ka nakoana hyperglycemia), ho kenngoa ha glucose molek'huleng ea hemoglobin, e tsamaeang le keketseho ea karolo ea HbAic. Haufinyane ho fumanoe likaroloana tse ling tse nyane tsa hemoglobin, Ala le A1b, tseo le tsona li nang le bokhoni ba ho ikopanya le glucose. Ho bakuli ba nang le lefu la tsoekere, lefu la hemoglobin A1 maling le feta 9-10% - tšobotsi ea boleng ba batho ba phetseng hantle.

Trasment hyperglycemia e tsamaisana le keketseho ea litekanyetso tsa hemoglobin A1 le A1c bakeng sa likhoeli tse 2-3 (nakong ea bophelo ba sele e khubelu ea mali) le kamora ho tloaela maemo a tsoekere ea mali. Column chromatography kapa mekhoa ea calorimetry e sebelisoa ho khetholla hemoglobin ea glycosylated.

Tlhaloso ea IRI

Teko ka tolbutamide (ho latela Unger le Madison). Kamora ho hlahloba tsoekere ea mali ka mpeng e se nang letho, 20 ml ea tharbutamide tharollo e fanoa kahare ho mokuli mme kamora metsotso e 30 tsoekere ea mali e hlahlojoa bocha. Bathong ba phetseng hantle, ho na le phokotso ea tsoekere ea mali ka ba fetang 30%, le ho bakuli ba nang le lefu la tsoekere - ka tlase ho 30% ea boemo ba pele. Ho bakuli ba nang le insulinoma, tsoekere ea mali e theoha ka liperesente tse fetang 50.