Matlapa a 600 a Berlition: litaelo tsa ho sebelisoa

ntho e sebetsang - thioctic acid 600 mg

Baeti: mafura a boima, ketane ea triglycerides e mahareng.

khetla: 70% sorbitol tharollo, e seng kristale (ho latela ntho e nang le metsi), 85% glycerin (ho latela ntho e nang le metsi), gelatin, titanium dioxide (E 171), carmine varnish (E 120).

Melemo ea pharmacological

Ho batho, thioctic acid e kenella ka potlako ka mor'a taolo ea molomo. Ka lebaka la phello e boletsoeng ea karolo ea pele ka sebete, ho ba le bioavailability ka ho felletseng (ha ho bapisoa le tsamaiso ea iv) ea thioctic acid e nkiloeng kahare ke eona e ka etsahalang. 20% Ka lebaka la ho ajoa ha lisele ka potlako, halofo ea bophelo ba thioctic acid e tsoang plasma bathong e ka ba metsotso e 25.

Tekanyo e lekanyelitsoeng ea bioavailability ea thioctic acid ha e nkuoa ka molomo ka mefuta e tiileng ea litekanyetso li feta 60% kamanong le tharollo ea molomo. Likahare tse kholo tsa plasma tsa approx. 4 mcg / ml, e fumanoe kamora ho ananeloa. 0.5 h ka mora ho tsamaisoa ha molomo ka 600 mg ea thioctic acid.

Litekong tsa liphoofolo (likhoto, lintja), ka ho sebelisa lebitso la radioactive, ho ile ha khonahala ho khetholla haholo-holo tsela ea ho hlaphoheloa sesepa (80-90%), ke hore, ka sebopeho sa metabolites. Ho batho, ke lintho tse sa reng letho tse fumanehang ka bongata ka har'a moroto. Biotransformation e etsahala haholo ka ho khutsisa ha oxidative ea ketane ea lehlakoreng (beta oxidation) le / kapa ka S-methylation ea li-thiols tse tsamaellanang.

Thioctic acid e fetoha ka har'a vitro ka li-ion complexes (kk.plplatin). Thioctic acid e nang le limolek'hule tsa tsoekere e kena metsong e rarahaneng e rarahaneng.

Mofumahali

Thioctic acid ke ntho e kang vithamine empa e le ntho ea tlhaho e sebetsang e le coenzyme ka har'a oxidative decarboxylation ea alpha-keto acid. Hyperglycemia e bakoang ke lefu la tsoekere e lebisa ho ho hlahisoa ha tsoekere ho liprotheine tsa matrix tsa methapo ea mali le ho etsoa ha lihlahisoa tsa ho qetela tsa lihlahisoa tsa glycosylation tse tsoetseng pele ("Advanced Products Glycosylation End Products"). Ts'ebetso ena e lebisa ho fokotseha ha phallo ea mali a endoneural le endoneural hypoxia / ischemia, e amanang le tlhahiso e eketsehang ea li-radicals tsa oksijene tse mahala tse senya methapo ea kutlo. Ka methapo ea kutlo, ho felile ha li-antioxidants, joalo ka glutathione, le hona ho fumanoe. Boithuto ba boithuto bo bonts'a hore acid ea thioctic e kenella lits'ebetsong tsena tsa biochemical, e fokotsa ho theoa ha lihlahisoa tsa glycosylation, ho ntlafatsa phallo ea mali a endoneural, le ho eketsa maemo a mmele a glutathione antioxidant. E boetse e sebetsa joaloka antioxidant khahlano le li-radicals tsa mahala tsa oksijene methapong e anngoeng ke lefu la tsoekere. Litlamorao tsena tse hlokometsoeng nakong ea liteko li fana ka maikutlo a hore ka thuso ea thioctic acid, ts'ebetso ea methapo ea kutlo e ka ntlafatsoa. Sena se sebetsa ho mathata a kutloisiso ea lefu la tsoekere la polyneuropathy, le ka hlahang e le dysesthesia le paresthesia (mohlala, ho chesa, bohloko, ho akheha kapa ho akheha). Lithuto tsa kliniki li bonts'a litlamorao tse ntle tsa thioctic acid ho kalafo ea matšoao a lefu la tsoekere la polyneuropathy, le tsamaeang le matšoao a tsebahalang a kang ho chesa, paresthesia, ho akheha ha hlooho le bohloko.

Pharmacodynamics le pharmacokinetics

Berlition e kenyelletsa e le motsoako o sebetsang thioctic asiti (alpha lipoic acid) ka sebopeho sa letsoai la ethylene diamine, e leng antioxidant ea nako e telele e kopanyang li-radicals tsa mahala le coenzyme ea alpha-keto acid decarboxylation process.

Phekolo ea Berlition e fokotsa maemo a plasma. tsoekere le ho eketsa sebete glycogenfokolisa khanyetso ea insulin, e tsosa cholesterol, e laola metabolism ea lipid le carbohydrate. Thioctic asitiKa lebaka la ts'ebetso ea eona ea tlhaho ea antioxidant, e sireletsa lisele tsa 'mele oa motho tšenyo e bakiloeng ke lihlahisoa tsa tsona tse bolileng.

Ho bakuli lefu la tsoekere thioctic acid e fokotsa ho lokolloa ha lihlahisoa tsa ho qetela glycation ea protheine liseleng tsa methapo, e eketsa microcirculation le ho ntlafatsa phallo ea mali, e eketsang khatello ea kelello glutathione antioxidant. Ka lebaka la bokhoni ba eona ba ho fokotsa litaba tsa tsoekere ea plasma, e ama tsela e 'ngoe ea metabolism ea eona.

Thioctic asiti e fokotsa ho bokella ha pathological polyol metabolites, ka tsela eo, e kenya letsoho phokotsong ea ho ruruha ha lisele tsa methapo. E tloaetse ho tsamaisoa ha methapo ea kutlo le metabolism ea matla. Ho nka karolo ho mafura a metabolism, ho eketsa biosynthesis phospholipidska lebaka leo sebopeho se senyehileng sa membrane ea sele se ntlafalitsoeng. E felisoa phello Lihlahisoa tsa metabolic ea joala (pyruvic asiti, acetaldehyde), e fokotsa tokollo e fetelletseng ea limolek'hule tsa mahala tsa oksijene, lia fokotsa ischemia le endoneural hypoxiamatšoao a kokobetsang polyneuropathyka sebopeho paresthesiaho tepella maikutlo, ho otsela le ho opeloa ke maoto le matsoho.

Ho ipapisitse le se boletsoeng ka holimo, acid ea thioctic e tšoauoa ka ts'ebetso ea eona ea hypoglycemic, neurotrophic le antioxidant, hammoho le ho ntlafatsa lipid metabolism ketso. Sebelisa ho hlophisoa ha motsoako o sebetsang ka foromo ethylene diamine letsoai e o lumella ho fokotsa botebo ba litlamorao tse mpe tse ka bang teng tsa thioctic acid.

Ha ho nooa ka molomo, asiti ea thioctic e potlakisa ebile e kenella ka kotloloho mokokotlong oa lijo (lijo tse nkiloeng ka tsela e tšoanang li fokotsa ho monya ka tsela e itseng). TCmax ho plasma e fapana pakeng tsa metsotso e 25-60 (ka taolo ea iv ea metsotso e 10-11). Plasma Cmax ke 25 38 mcg / ml. Bioavailability ea hoo e ka bang 30%, Vd ea boholo ba 450 ml / kg, AUC e ka bang 5 μg / h / ml.

Thioctic asiti e ka tšoaetsoa ke "phallo ea pele" ts'ebetsong ka sebete. Ho itšehla thajana ea lihlahisoa tsa metabolic tse entsoeng ka khona ke lits'ebetso khokahano le oxidation ea lehlakoreng. Excretion ka mokhoa oa metabolites ke 80-90% e etsoang ke liphio. T1 / 2 e nka metsotso e ka bang 25. Tlhahiso ea plasma ka kakaretso ke 10-15 ml / min / kg.

Contraindication

Berlition e hanyetsanoa ho bakuli ba ka tlase ho lilemo tse 18, bakuli ba nang le hypersensitivity ea motho ea sebetsang (thioctic acid) kapa lisebelisoa leha e le life tse thusang tse sebelisoang kalafo ea mofuta oa moriana, hammoho le ho nyekeloa le basali ba baimana.

Matlapa a 300 a Berlition, ka lebaka la ho ba teng ka foromo ena ea litekanyetso lactosecontraindicated ho bakuli ba le lefa lefe kapa lefe ho se mamelle tsoekere.

Bakeng sa mefuta eohle ea litekanyetso tsa moriana

• tlolo ea molao / phetoho ka tatso,
• fokotseha ha plasma dikaharetsoekere (ka lebaka la ntlafatso ea monko oa eona),
• matšoao hypoglycemiaho kenyelletsa ho senyeha ha pono, ho tsekela, hyperhidrosis, hlooho e bohloko,
• liponahatso tsa mmeleho kenyelletsa letlalo makhopho/ho hlohlonaurasharia rashurticaria), anaphylactic makala (maemong a ka thoko).

Ho kenyelletsa mefuta ea lithethefatsi tsa botsoali

• diplopia,
• ho chesa sebakeng sa ente,
• cramps,
• thrombocytopathy,
• letsolo
• ho hema hanyane le khatello e eketsehileng ea intracranial (e hlokometsoe maemong a taolo ea iv e potlakileng le ho feta ka mokhoa o ikemetseng).

Berlition, litaelo tsa tšebeliso (Mokhoa le litekanyetso)

Litaelo tsa semmuso tsa ts'ebeliso ea Berlition 300 li ts'oana le litaelo tsa ho sebelisoa ha Berlition 600 bakeng sa mefuta eohle ea litekanyetso tsa moriana ona (tharollo ea ente, likhakeletsi, matlapa).

Motsoako Berlition o reretsoeng ho hlophisoa ha infusions o laetsoe ka tekanyetso ea letsatsi le letsatsi ea 300-600 mg, e fanoang kahare letsatsi le letsatsi ka sekhahla bonyane metsotso e 30, bakeng sa libeke tse 2-4. Hang-hang pele ho ts'oaetso, tharollo ea lithethefatsi e lokisoa ka ho kopanya se kahare ho ampoule e le 'ngoe ea 300 mg (12 ml) kapa 600 mg (24 ml) le 250 ml Sodium Chloride ente (0,9%).

Mabapi le photosensitivity ea tharollo ea infusion e lokiselitsoeng, e tlameha ho sireletsoa ho pepesetsoa leseli, mohlala, e koaheletsoeng ka foil ea aluminium. Ka foromo ena, tharollo e ka boloka thepa ea eona nako e ka bang lihora tse 6.

Kamora libeke tse 2-4 tsa kalafo ka tšebeliso ea infusions, ba fetoha kalafo ka ts'ebeliso ea mefuta ea litekanyetso tsa moriana. Li-capsloma tsa Berlition kapa litafole li beoa ka tekanyetso ea tlhokomelo ea letsatsi le letsatsi ea 300-600 mg mme li nkuoa ka mpeng e se nang letho ka nako e ka bang halofo ea hora pele ho lijo, li nooa ka 100-200 ml ea metsi.

Nako ea ts'ebetso ea ho kenella le ea kalafo ea molomo, hammoho le monyetla oa boits'oaro ba bona bo phetoang, e khethoa ke ngaka e le 'ngoe ka bo eona.

Bongata

Matšoao a fosahetseng a overdose e leka-lekaneng thioctic asiti ea iponahatsa ho nyekeloa ho oela kahare hlatsa le hlooho e bohloko.

Maemong a tebileng, ho ka hlokomeloa letsoalo le foufetseng kapa kelello psychototorkakaretso cramps, hypoglycemia (pele ho komello), mathata a tebileng a acid-base lactic acidosisbohale necrosis ea mesifa skeleton ho hloleha hoa litho tse ngata, hemolysis, DIC, thibelo ea mosebetsi oa marapo.

Haeba u belaella phello e nang le chefo ea thioctic acid (mohlala, ha u nka karolo e fetang 80 mg ea moemeli oa phekolo ka kilo e le 'ngoe), ho khothalletsoa hore mokuli a kenelle sepetlele hang-hang' me hang hang a qale ho etsa mehato e amoheloang ka kakaretso ea ho loantša chefo ea kotsi (ho hloekisa pampitšana ea ka mpengkamohelo baloi jj.). Nakong e tlang, kalafo ea matšoao e bontšoa.

Phekolo lactic acidosis, ho tsieleha ka kakaretso le mafu a mang a ka behang bophelo ba mokuli a lokela ho hlaha ka tlung tlhokomelo e matla. E khethehileng antidote ha e khetholloe. Hemoperfusion, hemodialysis Mekhoa e meng e qobelloang ea ho taka ha e na thuso.

Sokolla foromo le sebopeho

Mofuta oa litekanyetso tsa Berlition 600 ke mohopolo bakeng sa ho hlophisoa ha tharollo ea motsoako: mokelikeli o hlakileng, botala bo bosehla ho 24 ml ka li-ampoules tsa khalase tse lefifi (25 ml) ka mohala oa ho phumula (label e tšoeu) le metsero e putsoa-e putsoa ka botala. Li-pcs tse 5. ka pokellong ea polasetiki, ka mokotleng oa karete e le 'ngoe.

1 ampoule e na le:

• ntho e sebetsang: thioctic acid - 0,6 g,
• likarolo tse thusang: ethylenediamine, metsi bakeng sa ente.

Mofumahali

Ka tsamaiso ea methapo ea lithethefatsi, khatello e phahameng ea thioctic acid e plasma e fihlella kamora metsotso e 30. C boleng_max hoo e ka bang 20 μg / ml. E thehiloe ke oxidation ea lehlakore la lehlakore, hammoho le conjugation. V_d (bophahamo ba modumo) ke 450 ml / kg. Thioctic acid le metabolites ea eona li hlahisoa ke liphio (tsela e ka sehloohong ea ho pepesa). Ho felisoa ha halofo ea bophelo ke metsotso e 25.

Berlition 600: litaelo tsa tšebeliso (litekanyetso le mokhoa)

Berlition 600 e fanoa kahare ka tsela ea tharollo ea infusion.

Qalong ea phekolo, moriana o fanoa ka tekanyetso ea 600 mg ka letsatsi (1 ampoule ea concentrate). Ha e le molao, nako ea kalafo ke libeke tse 2 - 4, kamora 'mele phepelo le pioctic acid ka mokhoa oa matlapa a 300-600 mg ka letsatsi e etsoa. Nako ea phekolo ka kakaretso, hammoho le tlhoko ea lithuto tse phetoang, li khethoa ke ngaka.

Ho lokisa tharollo ea infusion, lintho tse ka hare ho ampoule e le ngoe li hlapolotsoe ka 250 ml ea saline ea mmele. Tharollo e felileng e fanoa ka methapo, butle (bonyane metsotso e 30). Thioctic acid ke ntho e utloisang bohloko ka hona, lithethefatsi ha lia lokela ho belisoa pele ho nako. Tharollo e lokiselitsoeng e tlameha ho sireletsoa ho pepesehela leseli.

Litlamorao

• metabolism: ka seoelo - ho fokotseha ha glucose ea plasma, ka linako tse ling ho fihlela hypoglycemia (e bonahatsoang ke matšoao a kang ho tsekela, ho opeloa ke hlooho, pono e lerootho le ho ruruha haholo),
• tsamaiso ea methapo e bohareng le e poteletseng: ha se seoelo - phetoho ea tatso, bokuli ba pono ea methapo, ho tsitsipana,
• hematopoietic system: Haholo - thrombophlebitis, hemorrhagic rash, ho ata ha mali ka lebaka la ts'ebetso ea mokokotlo oa mokokotlo,
• karabelo: - ka seoelo - urticaria, ho hlohlona, ​​lekhopho letlalong, linyeoe tse ikhethileng - ho ts'oaroa ha anaphylactic,
• maikutlo a lehae: ka seoelo - maikutlo a tukang sebakeng sa ente ea tharollo ea infusion,
• Tse ling: ho hema ka thata le ho ikutloa o le boima hloohong (hlaha le tsamaiso e potlakileng ea moriana ebe o fetela ho bona).

Litaelo tse khethehileng

Bakuli ba nang le lefu la tsoekere ba nkang li-hypoglycemic agents tse khethehileng ba lokela ho hlahloba maemo a bona a tsoekere ea mali (haholo-holo qalong ea kalafo le Berlition 600). Sena se hlokahala bakeng sa thibelo e tlang ka nako ea boemo ba hypoglycemic. Maemong a mang, ho lokisoa ha lethalinyana la lithethefatsi tsa insulin kapa hypoglycemic bakeng sa tsamaiso ea molomo ho ka hlokahala.

Ka tsamaiso ea methapo, tsamaiso ea hypersensitivity e ka hlaha. Ponahalo ea ho hlohlona ha letlalo, ho nyekeloa ke pelo, malaise kapa matšoao a mang a hypersensitivity ke sesupo sa ho felisoa ha thioctic acid kapele.

Joala bo fokotsa katleho ea Berlition 600, ka hona nakong ea kalafo o lokela ho tlohela tšebeliso ea lino tse nang le joala.

Ke tharollo ea 0,9% ea sodium chloride feela e ka sebelisoang e le solvent bakeng sa mohopolo. Tharollo e lokiselitsoeng e tlameha ho bolokoa sebakeng se lefifi, ka ho eketsehileng e sirellelitsoe ke bobebe ke foil ea aluminium. Bophelo ba sehatsetsing ba tharollo ha bo sa feta lihora tse 6.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Ha ho na datha ka phello ea Berlition 600 ho bokhoni ba mokuli ba ho tsepamisa mohopolo kapa ho arabela ka potlako boemo, kaha ha ho e-so ho etsoe lithuto tse khethehileng. Nakong ea kalafo le lithethefatsi, ho lokela ho ba hlokolosi ha u etsa mosebetsi o mong le o mong o amanang le kotsi e eketsehileng ea bophelo le bophelo bo botle.

Ho sebelisana le lithethefatsi

Berlition 600 e khona ho theha li-chelate complexes ka tšepe, magnesium, calcium le tšepe tse ling, kahoo tšebeliso ea tsona e tšoanang e lokela ho qojoa.

Thioctic acid e ntlafatsa phello ea hypoglycemic ea lithethefatsi tsa insulin le molomo, hape e fokotsa phello ea kalafo ea sisplatin.

Ethanol e fokotsa haholo phello ea Berlition 600.

Ho itokisetsa tharollo ea infusion, u ke ke ua sebelisa tharollo ea fructose, dextrose, tsoekere, Ringer, hammoho le tharollo e sebelisanang le marokho a disulfide le li-SH-lihlopha.

Litšoantšiso tsa Berlition 600 ke: Tiolepta, Thioctic acid-Vial, Thiogamma, Thioctacid 600 T, Lipoic acid, Alpha-lipoic acid, Thioctic acid, Lipothioxin, Berlition 300, Thioctacid BV, Espa-Lipon, Octolipen, Lipolion, Lipolion, Tolipion, Pholion, Pholion, Pholion. .

Maikutlo a Berlition 600

Moriana o fumane litlhahlobo tse ngata tse ntle, kaha ha o sebetse feela, empa o mamelletsoe hantle le ke bakuli. Ka lebaka la phello ea eona e hanyetsang, Berlition 600 e sebelisoa hangata kalafong ea joala. E boetse e thusa hantle ho thibela le ho phekola mathata a lefu la tsoekere, ho sebetsa hantle ho feta lipapiso tse itseng.

Ho latela maikutlo, Berlition 600 ha e na liphoso, ntle le litšenyehelo tse phahameng haholo.

Tekanyetso le tsamaiso

Sekhahla sa letsatsi le letsatsi ke likhaba tse 1 tsa sethethefatsi Berlition® 600 (e lumellanang le 600 mg ea thioctic acid), e nooang hang, metsotso e ka bang 30 pele ho lijo tsa pele.

Ka paresthesia e matla, o ka qala ho etsa kalafo ea infusion ka thioctic acid.

Bana le bacha

Li-capsules tsa Berlition® 600 ha lia lokela ho nkuoa ke bana le bacha

Li-capslks tsa Berlition® tse 600 li lokela ho nkuoa ka mpeng e se nang letho, ho metha ka botlalo le ho noa metsi a mangata. Ho ja ka nako e le 'ngoe ho ka etsa hore ho ruruha ho be thata. Ka hona, ho bakuli ba khetholloang ke nako e telele ea gastric, ho bohlokoa haholo hore moriana o noe halofo ea hora pele ho lijo tsa hoseng.

Kaha ke bokuli bo sa foleng molemong oa lefu la tsoekere le lefu la tsoekere, ho ka 'na ha hlokahala hore u phekoloe nako e telele.

Motheo oa kalafo ea lefu la tsoekere la polyneuropathy ke matla a ho laola lefu la tsoekere.

Fomu ea ho lokolla le ho paka

Li-capsules tse 15 li kentsoe moqomong oa thipa oa blouse oa PVC film (lined PVDH) le foil ea aluminium.

Lipakete tse 1 kapa tse peli hammoho le litaelo tsa tšebeliso ea bongaka maemong a puo le lipuo tsa Serussia li kenngoa ka karete ea karete.

Boloka ka mocheso o sa feteng 25 ° C.

Qoba hole le bana!

Se ke oa sebelisa kamora letsatsi la ho felloa ke nako!

Tšebelisano

Bakeng sa thioctic asiti tšobotsi ke tšebelisano ea eona le baemeli ba kalafo, ho kenyeletsoa mechini ea tšepe ea ionic (mohlala, ka platinamu Cisplatin) Mabapi le sena, ts'ebeliso e kopaneng ea Berlition le litokisetso tsa tšepe li ka lebisa ho fokotseha ha katleho ea katleho.

Tsamaiso e tšoanang ea lithethefatsi tse nang le ethanol e lebisa ho fokotseheng hoa phello ea kalafo ea Berlition.

Thioctic acid e ntlafatsa tšebetso ea hypoglycemic litlhare tsa hypoglycemic tsa molomo le insulinho ka hloka hore ba fetole mofuta oa bona oa litekanyetso.

Berlition ea ente ha e lumellane le tharollo ea meriana e sebelisoang e le motheo oa ho hlophisoa ha motsoako oa infusion, ho kenyelletsa Tharollo ea ringer le Dextrosehammoho le tharollo e sebetsanang le marokho a sa thijoeng kapa lihlopha tsa SH-lihlopha.

Thioctic acid e khona ho theha mefuta e mengata e qhibilihang e nang le limolek'hule tsa tsoekere.

Lipehelo tsa Maemo a Phomolo ea meriana

Moqapi / Mong'a Setifikeiti sa Ngoliso

BERLIN-HEMI AG (MENARINI GROUP)

Gliniker Veg 125

12489 Berlin, Jeremane

Packer

Catalent Germany Schorndorf GmbH, Jeremane

Aterese ea mokhatlo e amohelang litletlebo tse tsoang ho bareki ka boleng ba lihlahisoa (thepa) sebakeng sa Rephabliki ea Kazakhstan:

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Nomoro ea mohala: +7 727 2446183, 2446184, 2446185

Berlition kapa Heptral

Mabapi le thepa ea hepatoprotective ea Berlition, sehlopha sa lithethefatsi se nang le phello ea tsosoloso ho lisele tsa sebete, e mong oa baemeli ba hlahelletseng ba Heptral. Ehlile, ho thata haholo ho taka lintho tse tšoanang mabapi le litlamorao tsa lingaka tsena tse peli tsa kalafo, hobane e ntse e le tsa lihlopha tse fapaneng tsa lithethefatsi, li kenyelletsa li-ingredient tse fapaneng tse sebetsang mme li khetholloa ka mekhoa e fapaneng ea ts'ebetso, leha ho le joalo, kalafo ea li-pathologies tsa sebete, hangata e nkela sebaka kapa e tlatsana.

Ka lebaka la phello e sa ithuteng hantle ea Berlition 'meleng oa bana, tšebeliso ea eona ho bana e hatelloa.

Litaelo tsa ho sebelisoa

Berlition e bua ka li-metabolism tse laolang metabolism ea mafura le lik'habohaedreite. Ntho e sebetsang ea lithethefatsi ke thioctic acid. Moriana o hlahisoa matlapeng le ka mokhoa oa ho tsepamisa mohopolo ho lokiseng tharollo ea infusion.

Berlition e fuoa bakuli ba nang le li-pathologies tse latelang:

• polyneuropathy, e thehiloe khahlanong le semelo sa lefu la tsoekere le joala bo sa foleng,
• steatohepatitis ea mefuta e fapaneng,
• sebete steatosis
• mafura a hepatosis
• ho tahoa ho sa feleng.

Litlamorao

Liphetho tse latelang tse sa rateheng li ka bonoa nakong ea kalafo le Berlition:

Urticaria

Bakeng sa mefuta eohle ea litekanyetso:

• allergy, e ka iponahatsang ka urticaria (ha u sebelisa mefuta ea ente, tsamaiso ea lintho tse kulang e ka hlaha ho fihlela anaphylaxis),
• ho fokotseha ha tsoekere ea mali, kaha tsoekere e monya haholoanyane.

Bakeng sa mefuta ea ente:

• cramps
• pono habeli
• intracranial hyperplasia le ho hema ka thata (a bonoa le tsamaiso ea meriana e potlakileng, litlamorao tsena tse sa rateheng),
• thrombophlebitis
• hemorrhages ka har'a letlalo le membrang ea mucous,
• mokopane oa theoha,
• hemorrhagic rash,
• latsoa ho sotha
• e chesa setsing sa ente.

Letlapa le le leng le na le 300 mg ea thioctic acid.

E le likarolo tse ling, e kenyeletsa:

• MCC
• maqephe
• tsoekere ea lebese
• fumed silica,
• E 572,
• sodium croscarmellose.

Khetla e na le lintho tse latelang:

• titanium tšoeu
• parafini ea metsi
• hypromellose,
• sodium dodecyl sulfate,
• dae E104 le E110.

Ho 1 ampoule ea ho tsepamisa mohopolo bakeng sa ho hlophisoa ha tharollo ea infusion, ho ka ba le 300 kapa 600 mg ea ntho e sebetsang.

Joalo ka lintho tse thusang, tsepamiso e na le metsi, ethylenediamine, le Berlition 300 le eona e na le macrogol.

Pharmacology le pharmacokinetics

Thioctic acid ke antioxidant. Joalo ka coenzyme ea mitochondrial multenzyme complexes, e nka karolo ho oxidative carboxylation ea propanonic acid le alpha-keto acid.

E fokotsa boemo ba tsoekere maling le ho eketsa khatello ea mali ea glycogen bokong, e thusa ho hlola ho hanyetsa insulin. E laola metabolism ea lipids le lik'habohaedreite, e ntlafatsa ts'ebetso ea sebete. E theola boemo ba tsoekere, lipids le cholesterol maling, e na le phello ea hepatoprotective.

Ha e nooa ka molomo, e monya hantle ho tsoa pampiring ea mala, ha ka nako e tšoanang le lijo, boemo ba adsorption bo fokotseha. Ka tsamaiso ea methapo, khatello e phahameng e shejoa kamora metsotso e 10, ha e nkuoa ka molomo kamora metsotso e 40-60.

Ha e fetela ka har'a sebete, ntho e sebetsang e tšelisoa, e tšeloa methapong.

Lipehelo tsa theko le polokelo

O ka reka moriana ho latela taelo ea ngaka.

Hoa hlokahala ho boloka tsepamiso ka mocheso o sa feteng 25 degrees sebakeng se lefifi moo bana ba ke keng ba e fumana.

Setlhare ha sea lokela ho bata.

Bophelo ba sehatsetsing ba ho tsepamisa mohopolo ke likhoeli tse 36.

Matlapa a lokela ho bolokoa sebakeng se sa fumaneheng ho bana, ka mocheso o sa feteng 25 degrees. Bophelo ba Shelf ke likhoeli tse 24.

(Siea maikutlo a hau ho litlhaloso)

* - Boleng bo pakeng tsa barekisi ba 'maloa ka nako ea tlhahlobo hase tlhahiso ea sechaba

Theko ea Berlition, ho reka

Naheng ea Rashea, theko e tlase ea Berlition 600 ho li-ampoules No. 5 ke li-ruble tse 900, 'me Berlition 300 ho ampoules No. 5 ke li-ruble tse 600. Theko ea Berlition 600 likotopong tsa No. 30 ke li-ruble tse ka bang 1000. Theko ea Berlition 300 matlapeng a No. 30 ke li-ruble tse ka bang 800.

Naheng ea Ukraine (ho kenyeletsoa Kiev, Kharkov, Odessa, joalo-joalo) Berlition ka karolelano e ka rekoa: li-ampoules 300 No. 5 - 280 hryvnia, li-ampoules 600 No. 5 - 540 hryvnia, li-capsules 300 No. 30 - 400 hryvnia, li-capsule tse 600 No. 30 - 580 hryvnia , matlapa a 300 No. 30 - 380 hhucnias.