Tsifran ST, matlapa a 500 mg 600 mg, 10 likhomphutha

"Tsifran" e laeloa mafu a latelang: tšoaetso ea genitourinary system (e sa foleng le e hlobaetsang pyelonephritis, cystitis, prostatitis, epididymitis), tšoaetso ea phepelo ea phepo (bronchopneumonia, pneumonia, exacerbations of chronic bronchitis, acute bronchitis, pleurisy, lung abscinctitis, empyethitis. , urethritis, tšoaetso ea litho tsa ENT (liphatlalatso tsa methapo ea methapo ea bohareng le e ka ntle, sinusitis, mastoiditis), tšoaetso ea letlalo le lisele tse bonolo (ho chesoa, maqeba, ulcers, tšoaetso ea ka mpeng, mafu a ka mpeng (peritonitis, feberu ea typhoid, cholangitis) noka nyenyane (endometritis, salpingitis), tšoaetso ea manonyello le masapo.

Tekanyetso le nako ea kalafo ea "Tsifran" e beoa ke ngaka, ka bomong maemong 'ohle, ho ipapisitse le bothata ba lefu lena, pathogen e fumanoeng, lilemo tsa mokuli, boima ba' mele le ts'ebetso ea liphio. Bakeng sa bana ba lilemo li 12 "Tsifran" e laetsoa palo ea letsatsi le letsatsi ea 5-10 mg ka kilo e le 'ngoe ea boima ba' mele, e arotsoe ka litekanyetso tse peli. Matlapa a lokela ho nooa pele ho lijo. Batho ba baholo "Tsifran" e tsamaisoa kahare (butle-butle) ka tsela ea infusions ka makhetlo a 200 mg makhetlo a 2 ka letsatsi bakeng sa ts'oaetso ea ts'oaetso ea mofets'e oa methapo le methapo e tlase. Bakeng sa tšoaetso e 'ngoe, moriana o fanoa ka bongata ba 200 mg ka nako ea lihora tse 12. Maemong a ho se sebetse hantle ha renal, tekanyetso ea letsatsi le letsatsi e fokotseha makhetlo a 2. Maemong a mang, kamora ho tsamaisoa ha iv, ba fetohela ho tsamaiso ea litlhare ka molomo. Phekolo ea mafu a tšoaetsanoang a hlobaetsang e etsoa bonyane matsatsi a 5-7. Kamora hore matšoao a nyamele, thupelo e ekeletsoa matsatsi a mang a 3.

Litla-morao le li-contraindication ts'ebeliso ea "Tsifran"

"Tsifran" e ka baka litlamorao tse kang ho ruruha, ho hlatsa, ho nyekeloa, ho opeloa ke mpa, hepatitis, ho opeloa ke hlooho, ho ruruha, ho tsekela, ho teneha, ho ferekana, ho akheha, migraine, ho thothomela hoa lits'ebetso, pono e fifatsang, ho fofonela, ho latsoa, ​​le morethetho oa pelo. , eosinophilia, leukopenia, leukocytosis, anemia, thrombocytosis, hemolytic anemia, ts'ebetso e eketsehileng ea li-enzyme tsa sebete, hyperglycemia, hematuria, glomerulonephritis, dysuria, polyuria, ho boloka methapo, ho tsoa mali, urethral yarns, ramatiki, tendon otlile, pseudomembranous colitis, candidiasis, generalized bofokoli.

Setlhare sena se kopantsoe ha ho na le hypersensitivity ho likarolo tsa eona, nakong ea kemaro le ho lactation, ho bana ba ka tlase ho lilemo tse 12. Ka tlhokomelo e khethehileng, "Tsifran" e sebelisoa ho batho ba nang le lipontšo tse matla tsa methapo ea methapo ea methapo, le likotsi tsa methapo ea kelello, bokuli ba kelello, lefu la sethoathoa, lefu la sethoathoa, lefu la sebete le / kapa ho se sebetse hantle ke botsofaling.

Moetsi

Letlapa le 1 le koahetsoeng le na:
Lintho tse sebetsang: ciprofloxacin hydrochloride USP, e lekanang ciprofloxacin 500 mg, tinidazole BP 600 mg,
excipients: microcrystalline cellulose, colloidal anhydrous silicon, magnesium stearate, sodium starch glycolate, sodium lauryl sulfate. Lithako tsa karolo e ka ntle ea likharafu: sodium starch glycolate, talc e hloekisitsoeng, sodium lauryl sulfate, microcrystalline cellulose, colloidal anhydrous silicon, magnesium stearate. Shell: Opadry mosehla, metsi a hloekisitsoeng.

Ketso ea pharmacological

Mofumahali
Tsifran ST ke litokisetso tse kopanetsoeng tse reretsoeng ho phekola tšoaetso e tsoakiloeng e bakoang ke likokoana-hloko tsa anaerobic le aerobic, hammoho le ts'oaetso ea phepelo ea ka mpeng, ka mohlala, lets'ollo kapa lets'ollo, amoebic kapa motsoako o kopaneng (amoebic le bacterial). Tinidazole e sebetsa hantle khahlanong le likokoana-hloko tsa anaerobic tse kang Clostridiumntyile, Clostridium perfringens, Bacteroides fragilis, Peptococcus le Peptostreptococcus anaerobius. Likokoana-hloko tsa Anaerobic li baka maloetse a mangata a ka mpeng, pelvis, matšoafo kapa litho tsa molomo. Ha tšoaetso ea anaerobic, hangata, ho na le motsoako oa libaktheria tsa anaerobic le aerobic. Ka hona, ka ts'oaetso ea anaerobic e kopantsoeng, lithibela-mafu tse sebetsang khahlanong le libaktheria tsa aerobic li eketsoa kalafong.

Ciprofloxacin ke lithibela-mafu tse pharalletseng tse loantšang likokoana-hloko tse ngata tsa aerobic gram-positive le gram-negative tse kang E. coli, Klebsiella spp., S.typhi le mefuta e meng ea Salmonella, P.mirabilis, P.vulgaris, Yersinia Enterocoilitica, Ps.aeruginosa, Shigella flexneri, Shigella sonnei, H.ducreyi, H.influenzae, N..gonorrhoeae, M. catarrhalis, V. cholerae, B. fragilis, Staph.aureus (ho kenyeletsoa le methicillin e thibelang mafu), Staph.epidermidis, Strep.pyogn, Strep. pneumoniae, Chlamidia, Mycoplasma, Legionella, le lefuba la Mycobacterium.

Mofumahali
Ka bobeli ciprofloxacin le tinidazole li kenelletse hantle ka har'a pampitšana ea gastrointestinal. Likarolo tse phahameng tsa karolo e ngoe le e ngoe li fihlelleha nakong ea lihora tse 1 ho isa ho tse peli. Tekanyetso e felletseng ea tinidazole ke 100%, mme protheine ea plasma e 12%. Ho felisoa ha halofo ea bophelo ke lihora tse ka bang 12-14. Ka potlako moriana o kenella linthong tsa 'mele, o fihlela likhahla tse phahameng moo. Tinidazole e kenella ka har'a mokelikeli oa "cerebrospinal" ka nako e lekanang le ea plasma mme e kenngoa ka har'a mongobo oa renal. Tinidazole e pepesitsoe ka hare ho bile e le ka har'a 50% ea mahloriso a eona ka plasma. Hoo e ka bang 25% ea tekanyetso e nkuoeng e ntsooe e sa fetohe ka har'a moroto.

Li-metabolism li etsa karolo ea 12% ea lethal dose e laetsoeng mme li boetse li pepesitsoe ka har'a moroto. Hammoho le sena, ho na le chebahalo e nyane ea tinidazole e nang le mantle.
Ciprofloxacin e kenella hantle kamora ho tsamaisoa ka molomo. Bioavailability ea ciprofloxacin e batla e le 70%. Ha e kopantsoe le lijo, monko oa ciprofloxacin o ea fokotseha. 20-40% ea lithethefatsi e tlama ho protheine ea plasma. Ciprofloxacin e kenella hantle ka maro a 'mele le lisele tsa' mele: mats'oafo, letlalo, mafura, mesifa le lefufuru, hammoho le litho tsa masapo le tsa mkojo, ho kenyeletsa le tšoelesa ea senya. Setlhare sena se fumaneha kahar'a manonyeletso, makhopho ka mpeng le ka mpeng, sperm, lymph, fluid, peritoneal, bile le secretion ea senya. Ciprofloxacin e tšeloa ka karolo e itseng ke sebete. Hoo e ka bang 50% ea lethal dose e nkuoeng e nkuoe e sa fetohe ka har'a morara, le 15% ka sebopeho sa metabolites e sebetsang, joalo ka oxociprofloxacin. Litholoana tse ling kaofela li hlahisoa ka har'a bile, li kenella butle-butle. Hoo e ka bang karolo ea 15-30% ea "profrofloxacin" e pepesetsoa mantle. Ho felisoa ha halofo ea bophelo ke lihora tse ka bang 3.5-4,5. Ho felisoa ha bophelo ba halofo ea bophelo ho ka leletsoa ka ho hloleha ho matla ha renal le ho bakuli ba tsofetseng.

• Tsifran ST e bontšoa bakeng sa kalafo ea tšoaetso e latelang:
• Phekolo ea mafu a tsoakiloeng a bakoang ke ts'oaetso ea anaerobic e potlakileng le likokoana-hloko tse sa hlaseleng: lefu le sa foleng la mokokotlo, lesapo la matšoafo, empyema, tšoaetso ea ka mpeng, mafu a tšoaetsanoang a mafu a basali, tšoaetso ea morao-rao ka ho ba teng hoa tšoaetso ea aerobic le anaerobic, osteomyelitis e sa foleng, letlalo le ts'oaetso ea lisele tse bonolo. leoto ”, liso tsa khatello ea maikutlo, tšoaetso ea lesapo la mokokotlo (ho kenyeletsa le peridontitis le periostitis).
• Phekolo ea letšollo kapa lets'ollo la etiology kapa e tsoakiloeng (amoebic le bacterial) etiology.

Bokhachane le pelehi

Ts'ebeliso ea Cyfran CT nakong ea kemolo ha e khothalletsoe. Tinidazole e ka ba le phello ea carcinogenic le mutagenic. Ciprofloxacin e tšela mekoallo ea hematoplacental. Ts'ebeliso ea tsifran ST e kopantsoe nakong ea kanyeso. Tinidazole le ciprofloxacin li epuoa lebeseng la matsoele. Ka hona, nakong ea lebone, haeba ho hlokahala ho sebelisa Tsifran ST, ho anyesa ho lokela ho emisoa.

Contraindication

• Cifran ST e kopantsoe le bakuli ba nang le hypersensitivity (allergy) ho tsoa ho eng kapa eng e tsoang ho fluoroquinolone kapa imidazole.
• Tsifran ST e boetse e hanyetsanoa ho bakuli ba nang le nalane ea mafu a hematologic. Ka thibelo ea masapo hematopoiesis, a hlobaetsang le porphyria.
• Tsifran ST e kopantsoe le bakuli ba nang le liso tsa methapo ea kutlo.
• Tsifran ST e kopantsoe le bakuli ba nang le bongoana (ho fihlela lilemo tse 18).

Ka tlhokomelo
Setlhare se lokela ho sebelisoa ka hloko ho bakuli ba nang le lefu la methapo e matla ea methapo ea methapo, le likotsi tsa mokokotlo, bokuli ba kelello, lefu la sethoathoa, lefu la sethoathoa, ho ruruha haholo le / kapa ho hloleha ha sebete.
Ha u sebelisa lithethefatsi ho batho ba tsofetseng, ha ho mathata a bohlokoa a ileng a bonoa. Leha ho le joalo, ho bakuli ba tsofetseng, ho fokotseha ho itšetlehileng ka ts'ebetso ea liphio hoa khoneha, ka hona tlhokomeliso e lokela ho ba teng ha u sebelisa lithethefatsi ho bakuli ba joalo.

Litlamorao

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho felloa ke takatso ea lijo, ho omella ka hanong ea molomo oa "metallic" molomong, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, bohloko ba ka mpeng, lefu la ho hlohlona, ​​jaundice ea cholestatic (haholo-holo ho bakuli ba nang le mafu a sebete a nakong e fetileng), hepatitis, hepatonecrosis.
Ho tsoa ts'ebetsong ea methapo: hlooho ea hlooho, ho tsekela, ho tepella ho eketsehileng, tšebelisano ea methapo (ho kenyelletsa le locomotor ataxia), dysarthria, peripheral neuropathy, makhopho a fokolisang, bofokoli, ho thothomela, ho hloka boroko, ho eketsa mofufutso, ho eketsa khatello ea methapo, pherekano, khatello ea maikutlo, hallucinations, hammoho le lipontšo tse ling tsa maikutlo a psychotic, migraine, ho akheha, mokokotlo oa mokokotlo oa mokokotlo.
Karolong ea litho tsa kutlo, ho fofonela le ho fofonela, pono e sa boneng (diplopia, phetoho ponong ea mmala), tinnitus, tahlehelo ea kutlo.
Ho tsoa ho tsamaiso ea pelo: tachycardia, arrhythmias ea pelo, e fokotse khatello ea mali.
Ho tsoa ho hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia
Karolong ea liparamente tsa laboratori: hypoprothrombinemia, tšebetso e eketsehang ea "sebete transaminases" le alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia
Ho tsoa ts'ebetsong ea moroto: hematuria, crystalluria (urkaline urine le tlhahiso e tlase ea moroto), glomerulonephritis, dysuria, polyuria, ho boloka methapo, ho fokolitse tšebetso ea "nitrogen" ea liphio, nephritis ea mahareng.
Litla-morao: ho hlohlona, ​​hives, ho theha marangrang a tsamaeang le ho tsoa mali, le ho hlaha ha marapo a manyane a etsang marang-rang, feberu ea lithethefatsi, ho ruruha hoa letlalo letlalong (petechiae), ho ruruha hoa sefahleho kapa larynx, ho hema hanyane, ho phuthoa hoa moea, ho phahamisa mahlo, ho phahamisa mahlo. erythema multiforme exudative (ho kenyeletsoa le Stevens-Johnson syndrome), chefo e nang le chefo e hlahisang chefo ea morao-rao (lefu la Lyell).
Tse ling: arthralgia, ramatiki, tendovaginitis, ropo ea tendon, asthenia, myalgia, superinfection (candidiasis, pseudomembranous colitis), ho chalatsa sefahleho.

Tšebelisano

Tinidazole
E ntlafatsa phello ea li-anticoagulants tse sa tobang (ho fokotsa kotsi ea ho tsoa mali, lethal dose le fokotsoe ka 50%) le ketso ea ethanol (disulfiram-like reaction).
E lumellana le sulfonamides le lithibela-mafu (aminoglycosides, erythromycin, rifampicin, cephalosporins).
Ha ho kgothaletswe ho fana ka taelo le ethionamide.
Phenobarbital e potlakisa metabolism.
Koprofloxacin
Ka lebaka la ho fokotseha ha ts'ebetso ea li-process tsa microsomal oxidation ho hepatocytes, e eketsa khatello mme e lelefatsa halofo ea bophelo ba theophylline (le li-xanthine tse ling, ka mohlala ka caffeine) ea lithethefatsi tsa molomo tsa hypoglycemic (PM), li-anticoagulants tse sa tobang, mme e thusa ho fokotsa index ea prothrombin.
Ha e kopantsoe le lithethefatsi tse ling tsa antimicrobial (lithibela-mafu tsa beta-lactam, aminoglycosides, clindamycin, metronidazole) hangata synergism e bonoa.
E ntlafatsa phello ea nephrotoxic ea cyclosporrin, keketseho ea serum creatinine e bonoa, ho bakuli ba joalo, letšoao lena le hloka ho hlahlojoa makhetlo a 2 ka beke

Ka nako e ts'oanang, e ntlafatsa phello ea li-anticoagulants tse sa tobang.
Tsamaiso ea molomo hammoho le Fe e nang le lithethefatsi, li-sucralfate le lithethefatsi tsa antacid tse nang le Mg2 +, Ca2 +, A13 + e lebisa ho fokotseha ha ho nkuoa ha ciprofloxacin, ka hona e lokela ho laeloa lihora tse 1-2 pele kapa lihora tse 4 kamora ho sebelisa litlhare tse ka holimo.
Lithethefatsi tse seng khahlanong le ho ruruha (ntle le acetylsalicylic acid) li eketsa kotsi ea ho tsuoa.
Didanosine e fokotsa ho monya ha ciprofloxacin ka lebaka la sebopeho sa meralo le eona, e nang le Mg2 +, A13 + e fumanehang ka didanosine.
Metoclopramide e potlakisa ho koaloa, e lebisang ho fokotseha ha nako ea ho fihlela mahloriso a eona a phahameng.
Ts'ebetso e kopanetsoeng ea lithethefatsi tsa uricosuric e lebisa ho fokotseng ho felisoa (ho fihla ho 50%) le keketseho ea plasma mahloriso a ciprofloxacin.

Bongata

Ha ho na litlhare tse tobileng, ka hona, kalafo e nang le lithethefatsi tse ngata tsa cyfran CT e lokela ho ba le matšoao mme e kenyeletse mehato e latelang:
- Qalella ho hlatsa kapa ho hlasela ka mpeng.
- Ho nka mehato ea hydration e lekaneng ea 'mele (kalafo ea infusion).
- Tlhokomelo e tšehetsang.

Litaelo tse ikhethang

Ho khothalletsoa ho qoba ho pepesetsoa khanya ea letsatsi ka ho fetelletseng nakong ea phekolo le Cifran ST, hobane bakuli ba bang ba ileng ba phekoloa ka fluoroquinolones ba ne ba e-na le karabelo ea ho nka lifoto. Haeba ho ba le karabelo ea ho nka lifoto, khaotsa ho sebelisa lithethefatsi hanghang.
Ha o sebelisa tinidazole, ho a khonahala (empa ho sa tloaelehe) ho nts'etsopele urticaria e akaretsang, ho ruruha ha sefahleho le larynx, ho theola khatello ea mali, bronchospasm le dyspnea. Haeba mokuli a kulisoa ke imidazole e tsoang ho efe kapa efe, ebe kutloelo-bohloko ba kutloisiso ka tinidazole e ka ba teng, nts'etsopele ea karabelo ea sefapano-allergic ho ciprofloxacin e ka etsahala le ho bakuli ba hanang mefuta e meng e tsoang ho fluoroquinolone. Ka hona, haeba mokuli a e-na le karabelo leha e le efe e kulisoang ke lithethefatsi tse tšoanang, monyetla oa mehopolo ea mefuta-futa ea cyfran ST o lokela ho nahanoa.
Ka ts'ebeliso e kopaneng ea tinidazole e nang le joala, marotholi a bohloko a ka mpeng, ho nyekeloa le pelo le ho hlatsa li ka hlaha. Ka hona, tšebeliso e kopaneng ea Cifran ST le joala bo hokahane.

Bakeng sa ho qoba nts'etsopele ea kristallaro, lethal dose e khothalletsoang ea letsatsi le leng le le leng ha ea lokela ho fetisoa, tšebeliso ea metsi a lekaneng le ho boloka motsoako oa moroto oa acid le tsona oa hlokahala. E baka lits'oants'o tse mpe tsa moroto.
Nakong ea kalafo, o lokela ho hana ho etsa lintho tse kotsi tse hlokang tlhokomelo e eketsehileng le lebelo la karabelo ea kelello le koloi.
Bakuli ba nang le lefu la sethoathoa, nalane ea ho ts'oaroa, maloetse a methapo le tšenyo ea mokokotlo, ka lebaka la kotsi ea karabelo e mpe ho tsoa ho tsamaiso ea methapo e meholo, moriana o lokela ho fuoa feela lipontšo tsa "bohlokoa".
Haeba letšollo le matla le le lelelele le etsahala nakong ea kalafo kapa kamora kalafo, ts'oaetso ea lefu la pseudomembranous colitis e lokela ho qheleloa ka thoko, e leng ho hlokang hore ho tlosoe hanghang lithethefatsi le tumello ea kalafo e nepahetseng.
Ka ponahalo ea bohloko ka hare ho tendon kapa ha matšoao a pele a tenosynovitis, kalafo e lokela ho khaotsa.
Nakong ea kalafo, setšoantšo sa mali a pherekano se lokela ho hlahlojoa.
Ts'ireletso le ho sebetsa hantle bakeng sa kalafo le thibelo ea tšoaetso ea anaerobic ho bana ba ka tlase ho lilemo tse 12 ha li e-so theoe.

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi, 500 mg

Letlapa le leng le na le

ntho e sebetsang - ciprofloxacin hydrochloride 582.37 mg (e lekanang le ciprofloxacin) 500.00 mg

baamohelang: microcrystalline cellulose (Avicel PH101), starch ea poone, starch ea poone (bakeng sa gluing), magnesium stearate, talc, anhydrous colloidal silicon diode, mofuta oa sodium starch glycolate (mofuta A), metsi a hloekisitsoeng

Shell: metsi a hloekisitsoeng, opadry OY-S-58910 tšoeu (hypromellose E464, titanium dioxide E171, polyethylene glycol 400, talc E553

Matlapa a bopehileng joaloka Capsule a kopantsoeng le filimi e koahelang ho tloha tšoeu ho isa ho e tšoeu, e ngotsoe ka "500" ka lehlakoreng le leng ebile e boreleli ka lehlakoreng le leng.

Melemo ea pharmacological

Mofumahali

Kamora ho tsamaisoa ka molomo, ciprofloxacin e kenella ka potlako ho tsoa likarolong tse ka holimo tsa mala, ebe e fihla mochesong o phahameng oa serum (Cmax) kamora metsotso e 60-90. Ho ja ha ho ame tekanyo ea ho amoheloa ha moriana. Kamora ho nka tekanyetso e le 'ngoe ea 250 mg le 500 mg, Cmax ke 0.8-2.0 mg / L le 1.5-2.9 mg / L, ka ho latellana. Absolute bioavailability ke 70-80%. Cmax e na le ts'ehetso e atamelaneng ea moriana o nkuoeng.

Bophahamo ba phofo ea profrofloxacin ke 2-3 l / kg, e netefatsang phepelo e ts'oanang ho litho tsohle le lisele. Kaha tekanyo ea ho tlama liprotheine tsa plasma ke 20-30% feela 'me boholo ba lithethefatsi li hlahisoa ka plasma ka sebopeho se seng se nang le ionized, hoo e batlang e le lethaliti lohle le nkuoeng ka mokhoa o sa feteng le fetisetsoa sebakeng se eketsehileng.

E tšeloa ka har'a sebete. Ho felisoa ha halofo ea bophelo ho etsa lihora tse 3-5. E tšeloa haholo ka har'a moroto o sa fetoheng, ka tsela e itseng e le ka metabolites. Hoo e ka bang 10% - e pepesitsoe ka mala, e ka bang 1% ea ciprofloxacin e qhaliloe ka har'a lero.

Pharmacokinetics ka lihlopha tse khethehileng tsa bakuli. Liphetho tsa lithuto tsa pharmacokinetic tsa ciprofloxacin ho bakuli ba tsofetseng li bonts'a bolelele ba halofo ea bophelo. Liphapang tsena ho li-pharmacokinetics ha li bohlokoa ka tleliniki..

Ho hloleha hape Ho bakuli ba nang le ts'ebetso ea renal e fokotsehileng, halofo ea bophelo ba ciprofloxacin e telele ho feta. Maemong a mang, ho ka hlokahala phetoho ea litekanyetso..

Ho hloleha ha sebete. Lithutong tsa pele tse amang bakuli ba nang le cirrhosis ea sebete e tsitsitseng, ha ho liphetoho tse kholo maemong a pharmacokinetic a ciprofloxacin a fumanoe. Leha ho le joalo, pharmacokinetics ea ciprofloxacin ho bakuli ba nang le ho hloleha ha sebete ka mokhoa o hlabang ha e utloisisehe ka botlalo.

Tšebelisanong ea lithethefatsi. Tabeng ea ho nka matlapa a ciprofloxacin ka nako e le 'ngoe le lijo, ho kenngoa ha moriana ho fokotseha butle, ka lebaka la hore khatello e phahameng ea ciprofloxacin maling e fihlella kamora lihora tse ka bang peli, eseng kamora hora e le' ngoe. Ka nako e ts'oanang, ho monya ha ciprofloxacin ka kakaretso ha ho na mathata. Ha e kopantsoe le li-antacid tse nang le magnesium kapa aluminium hydroxide, bioavailability ea ciprofloxacin e ka fokotsoa ka 90% .

Ciprofloxacin e kopantsoe le bakuli ba fumanang tizanidine.

Ciprofloxacin e fokotsa tumello ea theophylline, e ka lebisang keketseho ea mahloriso a serum theophylline le kotsi e eketsehang ea likoluoa ​​tsa tsamaiso ea methapo ea kutlo le litsotsi tse ling tse fapaneng. Ciprofloxacin hape e fokotsa ho pepeseha ha caffeine mme e thibela ho boptjoa ha paraite ea metabolite ea eona..

Mofumahali

Mokhoa oa ketso. Ketso ea bactericidal ea ciprofloxacin e bakiloe ke thibelo ea enzymes topoisomerase II (DNA gyrase) le topoisomerase IV, tse hlokahalang bakeng sa ho pheta, ho ngola, ho lokisa le ho pheta-pheta DNA ea baktheria.

Mokhoa oa nts'etsopele ea ho hanyetsa. Khanyetso ea Fluoroquinolone e amana haholo le liphetoho tse bang teng liphatseng tsa lefutso tsa DNA, ho kenella habonolo ha membrane ea sele ea kantle ea libaktheria, kapa ts'ebetso ea liprotheine tsa ejection, tse lebisang ho tloseng ha fluoroquinolones seleng. Maemong in vitro ciprofloxacin ho hanyetsa ho fetoha butle butle ka liphetoho tse ngata. Keketseho ea ho hanyetsa ciprofloxacin ka lebaka la liphetoho tse iphetotseng hangata e fapana ho tloha