U ka nka Octolipen ea lefu la tsoekere?

Ho ima le ho nyopa ho nka Oktolipen ha e khothalletsoe, hobane hajoale ha ho na leseli le qaqileng mabapi le hore na ts'ebeliso ea eona e ama nts'etsopele ea lesea le hore na e ama lebese la matsoele.

Ho latela litaelo, Oktolipen nakong ea kemolo e tšoaetsanoa ka lebaka la ho haella ha tlhaiso-leseling ea kliniki mabapi le ts'ebeliso ea thioctic acid nakong ena.

Nakong ea lithuto tsa bosholu ba ho ba le bana, menyetla ea ho ba le bokhoni ba ho ba le bana le litlamorao tsa lithethefatsi ha lia ka tsa bonahala.

Ho sebelisana le lithethefatsi

E le hore kalafo e be le tlhahiso, ho lokela ho nahanoe likarolo tse latelang tsa moriana:

• Oktolipen e ntlafatsa litlamorao tsa li-hypoglycemic agents le insulin,
• ha e sebelisoa hammoho, meriana e ka fokotsa ts'ebetso ea Cisplatin,
• Litokisetso tse nang le tšepe, magnesium kapa calcium li lokela ho nkuoa pele kapa kamora Oktolipen ka lekhalo la lihora tse 'maloa,
• moriana o ntlafatsa lithibela-mafu tsa li-glucocorticosteroids,
• tlasa tšusumetso ea joala, katleho ea Octolipen ka boeona ea fokotseha.

Mabapi le sena, hoa hlokahala ho fetola tekanyetso ea lithethefatsi le ho boloka nako e behiloeng. Leha ho le molemo ho qoba ho kopanya sethethefatsi sena ka mekhoa e sa lokelang.

Ka linako tse ling bakuli ba hana ho nka moriana ona 'me ba botsoa ho khetha li-analogues tse theko e tlase. Maemong a mang, ho nkeloa sebaka ke ntho e hlokahalang ka lebaka la mathata a moriana o itseng.

Lithethefatsi tse ikhethang

Thiogamma ke sesebelisoa se thusang ho tsitsisa mekhoa ea metabolic. Naha eo motsoako ona o entsoeng ka eona ke Jeremane. E hlahisoa ka mokhoa oa:

• lipilisi
• tharollo ea infusion (ka marotholi),
• tsepamisa mohopolo bakeng sa ho etsa tharollo ea infusion (ente e etsoa ho tsoa ka ampoule).

Matlapa a na le ntho ea mantlha - thioctic acid, tharollong ea infusion - letsoai la meglumine ea thioctic acid, le ho tsepamisa mohopolo bakeng sa infusions ea kahare - meglumine thioctate. Ntle le moo, mofuta o mong le o mong oa moriana o na le likarolo tse fapaneng tsa thuso.

Thioctic acid (lebitso la bobeli ke alpha lipoic) ke antioxidant e hlophisitsoeng 'meleng. E theola tsoekere ea mali 'me e eketsa boemo ba glycogen bokong, boo, bo fetisang ho hanyetsa insulin.

Ntle le moo, thioctic acid e laola metabolism ea lipids, lik'habohaedreite le cholesterol. E ntlafatsa ts'ebetso ea sebete le li-neurons tsa trophic, e imolla mmele oa chefo.

Ka kakaretso, alpha lipoic acid e na le litlamorao tse latelang:

• hepatoprotective
• lipid-lowing,
• hypocholesterolemic,
• hypoglycemic.

Ha ho phekoloa lefu la tsoekere, alpha-lipoic acid e tsamaisa phallo ea mali ea endoneural, e eketsa boemo ba glutathione, ka lebaka leo, ho na le ntlafatso mosebetsing oa methapo ea methapo.

Thioctic acid e sebelisoa haholo ka sepheo sa ho ikhabisa: e boreleli marameng sefahlehong, e fokotsa kutloelo-bohloko ea letlalo, e folisa maqeba, hammoho le mesaletso ea makhopho, 'me e tiisa pores.

Phello ea hypoglycemic ea Oktolipen e eketseha haeba litokisetso tsa insulin le tafole tsa phello e tšoanang li nkuoa ka nako e le 'ngoe. Sena se ka lebisa ho theoha ha tsoekere ea mali ho ea boemong bo mahlonoko.

Haeba ts'ebeliso e kopaneng ea lithethefatsi e hlokahala, joale e lokela ho tsamaisana le ho lekola khafetsa maemo a tsoekere. Haeba ho kheloha mekhoa e sa amoheleheng, tekanyetso ea insulin kapa lithethefatsi tse ling tsa hypoglycemic lia lokisoa.

Nakong ea ho sebelisa lithethefatsi, motho o lokela ho hana lino tse tahang: litlamorao tsa kalafo ea α-lipoic acid e fokotseha tlasa ts'usumetso ea joala ba ethyl. Boteng ba Oktollipen, phello ea kalafo ea cosplatin le eona e fokotsehile. Thioctic acid ha e lumellane le tharollo ea ringer le dextrose.

Hoa hlokahala ho hana taolo e tšoanang ea Oktolipen ka litokisetso tsa tšepe le magnesium, hammoho le ts'ebeliso ea lihlahisoa tsa lebese le eona. Haeba Oktolipen a nkuoa hoseng, joale litokisetso le lihlahisoa tse nang le calcium, magnesium le tšepe li lokela ho siuoa mantsiboea. Tlas'a tšusumetso ea α-lipoic acid, phello e khahlanong le ho ruruha ea glucocorticosteroids e matlafatsoa.

• cisplatin - phello ea eona ea fokotsoa ha e kopantsoe le thioctic acid ka mokhoa oa tharollo ea infusion,
• li-insulin tsa molomo, insulin - phello ea lithethefatsi tsena e ea ntlafatsoa,
• glucocorticosteroids - ba bona ba-ba khahlanong le ho ruruha eketsa,
• ethanol le metabolites ea eona - mosebetsi oa kalafo oa thioctic acid oa fokola,
• Litokisetso tsa khalsiamo, magnesium le tšepe - ka taolo e tšoanang ea molomo, hoa khoneha ho theha mochini o nang le tšepe (khefu pakeng tsa litekanyetso tsa baemeli bana mme Oktolipen e lokela ho ba bonyane lihora tse 2).

Tharollo e lokiselitsoeng bakeng sa infusion ea intravenous ha e lumellane le tharollo ea levulose, tsoekere, tharollo ea Ringer, le likhomphutha (ho kenyelletsa le tharollo ea tsona) tse arabelang ka lihlopha tsa disulfide le tsa SH.

Ha thioctic acid e kopana le limolek'hule tsa tsoekere, ho theha metsoako e rarahaneng ea qhibilihang.

Matšoao a ho sebelisoa

Nka Octolipen ho latela melao e latelang:

1. Ho hlophisoa ha letlapa ho sebelisoa ka molomo feela le ka mpa e se nang letho. Se ke oa e sefa kapa ea e hlafuna.
2. Motsoako o atileng haholo ke 600 mg, empa ha ho hlokahala, ngaka e ka o eketsa.
3. Nako ea thupelo ea kalafo e itšetlehile ka setšoantšo sa kliniki le matla a kalafo.
4. Liente li lokela ho kenngoa mothapong. Ho lokisa motsoako, o hloka li-ampoules tse peli tsa moriana. Li kenngoa ka har'a tharollo ea sodium chloride.
5. Tekanyetso e tloaelehileng ha u sebelisa mokhoa oa mokelikeli oa lithethefatsi ke 300-600 mg. Nako ea tlhahiso e joalo e kanna ea fapana.
6. Khafetsa, qalong ea kalafo, ho sebelisoa tharollo (libeke tse 2), ebe mokuli o fetisetsoa ho Oktolipen matlapeng.

Khetho ea litekanyetso e etsoa ka bonngoe. Sena se susumetsoa ke lintlha tse ngata tse fapaneng, 'me ke setsebi feela se ka li tsotellang.

Pele o nka moriana ona, o hloka ho tseba hore na o sebelisa li-pathologies life. Matšoao a ts'ebeliso ea lithethefatsi Tiogamm ke:

1. Lefu la kelello la tsoekere ke tlolo ea tsamaiso ea methapo mabapi le ho hlola methapo e menyenyane ea mali ho bakuli ba nang le lefu la tsoekere.
2. Polyneuropathy ke lesapo le fapaneng la methapo ea methapo.
3. Li-pathologies tsa sebete - hepatitis, cirrhosis, mafura a mafura.
4. Tšenyo ea methapo ea pelo ka lebaka la tšebeliso e mpe ea joala.
5. Ho kenella ka har'a 'mele (li-mushroom, letsoai la tšepe tse boima, jj).

Ts'ebeliso ea lithethefatsi e latela mofuta oa eona oa tokollo. Mohlala, matlapa (600 mg) a nooa ka molomo, ntle le ho hlafuna le ho nooa ka metsi, hang ka letsatsi. Nako ea phekolo e nka likhoeli tse 1 ho isa ho tse peli, ho latela hore na lefu lena le boima hakae. Pheko e phetoang e khothalletsoa makhetlo a 2-3 ka selemo.

Kenyelletso ea lithethefatsi Thiogamm Turbo e hlaha ka botsoali ka ho kenella ka hare ho marang-rang. Ampoule e na le 600 mg ea tharollo, tekanyetso ea letsatsi le letsatsi ke ampoule e le 'ngoe. Moriana o fanoa butle butle ka ho lekaneng, hangata e ka ba metsotso e 30, ho qoba karabelo e mpe e amanang le ho kenella ha tharollo kapele. Nako ea phekolo e nka libeke tse peli ho isa ho tse 'ne.

Ho tsepamisa mohopolo bakeng sa tharollo ea infusion ho lokiselitsoe ka tsela e latelang: 1 ampoule (600 mg) ea boitokisetso ba Tiogamma e kopantsoe le 50-250 mg ea tharollo ea sodium chloride (0.9%). Ka mor'a moo, motsoako o lokiselitsoeng ka botlolong o koaheloa ka mochini o sirelletsang letlalo. Ka mor'a moo, tharollo e tsamaisoa hang-hang (ka metsotso e 30). Nako e phahameng ea ho boloka tharollo e lokisitsoeng ke lihora tse 6.

Setlhare se tlameha ho bolokoa sebakeng se lefifi se sa fumanehe ho masea ka mocheso o sa feteng 25C. Bophelo ba lishelefo tsa moriana ona ke lilemo tse 5.

Litharollo li karolelanoa. Ke ngaka feela e tlang ho fana ka kalafo ka moriana ona, ho theha mofuta oa kalafo le ho lekanya litekanyetso ho latela litšobotsi tsa motho ka mong.

Ka boteng ba maloetse a mangata a amanang le tšenyo ea methapo ea methapo le mathata a metabolic, litsebi li khothaletsa ho nka Oktolipen. Matšoao a ts'ebeliso ea lipoic acid a lumella ts'ebeliso ea lithethefatsi kalafong ea li-pathologies tse latelang:

• polyneuropathy, lefu la tsoekere kapa joala,
• insulin ho hanyetsa mofuta oa 1 le lefu la tsoekere la 2
• mafura
• hepatitis e sa foleng
• atherosulinosis
• pancreatitis
• cholecystitis.

Thioctic acid, e leng motsoako o ka sehloohong oa lithethefatsi, e na le phello e kang ea insulin, e baka tsoekere e potlakileng ea tsoekere. Ho monya ha eona ka potlako, hammoho le ts'ebetso ea metabolism ea mafura, e thusa ho fokotsa boima, kahoo e ka sebelisoa bakeng sa ho fokotsa boima ba 'mele.

Matšoao a ts'ebeliso ea Oktolipen a buella mofuta ona oa lefu la tsoekere, kaha o ntlafatsa ts'ebetso ea insulin ea hae le lithethefatsi tse nkang sebaka sa eona

Ts'ebeliso ea antioxidant ena ha e lumelloe ho basali baimana le ba anyang, hammoho le bana ba ka tlase ho lilemo tse 16. Thibelo ts'ebelisong ea lithethefatsi e thehiloe hobane phello ea eona ha e utloisisoe hantle. Ka hlokolosi, o hloka ho nka lithethefatsi bakeng sa bakhanni, ka lebaka la kotsi ea hypoglycemia.

Fana ka litlhare lithutong ho tloha ho likhoeli tse 1 ho isa ho tse tharo. Nako ea kalafo le litekanyetso li ipapisitse le boima ba lefu lena, mme li ikemiselitsoe ka kotloloho ho mokuli ka mong. Ho fapanyetsana ha mefuta ea infusion le letlapa ho eketsa katleho ea kalafo. Oktolipen e fumaneha ka mefuta e mengata.

• lipilisi le lipilisi
• Tharollo e amehileng ka ampoules.

Boemong ba pele ba maloetse le ho theola boima ba 'mele, ho hlokahala hore letsatsi le leng le le leng ho be le polelo ea acid. Litafole le li-capsules li nooa feela 1 ka letsatsi, ho fihlela mots'ehare. Nako e pakeng tsa ho nka meriana le lijo tsa hoseng e lokela ho ba metsotso e 25-30. Tekanyo e phahameng ea letsatsi le letsatsi e lumelletsoeng kalafo kapa prophylaxis ha e feta 600 mg.

Tsamaiso ea Drip ea Okolipen e khothalletsoa ho bakuli ba nang le polyneuropathy e matla. E boetse e hlalosoa e le karolo ea kalafo e rarahaneng, bakeng sa chefo, ho mpefatsa maloetse a sebete le pampitšana ea mala. Tharollo ea infusion e lokisoa kapele pele ho tsamaiso, kaha lithethefatsi li na le kutloisiso 'me li lahleheloa ke thepa ka mor'a ho kopana ka nako e telele le khanya.

Tharollo ea 0,9% ea sodium chloride e sebelisetsoa ho hlapolla khatello ea maikutlo. Ho thibetsoe ho e hlapolla ka tharollo ea tsoekere, hobane ha e kopana le eona, phello ea kalafo e nyamela. Tharollo e felileng e fanoa ka methapo, ho opa ka nako e 1 hoseng, thupelo e se e fihlile ho khoeli e le 'ngoe. Bakeng sa ente e le 'ngoe, bophahamo ba letsoai ke 250 di ml, ka kenyelletso ea li-ampoule tse peli tsa tsepamiso.

Bakeng sa ba fuoeng Octolipen li-capsule kapa matlapa a 600, litaelo tsa tšebeliso li kenyelletsa ho nka tekanyetso ea letsatsi le letsatsi hoseng ka mpeng e se nang halofo ea hora pele ho lijo. Tšebeliso ea lijo ka nako e tšoanang e fokotsa katleho ea moriana. Ho hlafuna le matlapa le likhohlopo ha li khothalelitsoe.

• Tekanyo e khothalletsoang ke 1 tab. (600 mg) 1 nako / letsatsi.

Pheko ea mohato e ka etsahala: Tsamaiso ea molomo ea lithethefatsi e qala kamora beke ea libeke tse 2 ea tsamaiso ea batsoali ka thioctic acid. Boemo bo phahameng ba ho nka litafole ke likhoeli tse 3. Maemong a mang, kalafo ea Oktolipen e fana ka tlhahiso ea tšebeliso e telele. Nako ea ho amoheloa e khethoa ke ngaka e eang.

• diabetesic polyneuropathy,
• lekhoba la joala la joala.

Lipilisi, matlapa

Li-capsules tsa Okolipen le matlapa a nooa ka molomo, ka mpeng e se nang letho, halofo ea hora pele ho lijo tsa hoseng, ntle le ho qhekella le ntle le ho phatloha, ka metsi a lekaneng.

Moriana o khothalletsoa hore o nooe hanngoe ka letsatsi ka tekanyetso ea 600 mg (likhabapo tse peli / 1). Maemong a mang, ho khethoa ha kalafo ea mohato hoa khoneha: nakong ea libeke tse 2 ho isa ho 2 tsa thuto, thioctic acid e tsamaisoa ka mokhoa oa infusions (ho sebelisa mohopolo), ebe matlapa a nooa tekanyetso e tloaelehileng.

Nako ea kalafo e khethoa ke ngaka. Matlapa a Octolipen 600 mg ha a khothalletsoe ho feta likhoeli tse 3, empa haeba ho hlokahala, joalo ka ha ho laetsoe ke ngaka, ts'ebeliso ea lithethefatsi e kanna ea ba telele.

Litaelo tsa ho sebelisoa Oktolipen

Ho lokisa tharollo ea infusion, ho hlokahala hore u hlapolle li-ampoule tse 1 kapa tse 2 ho 50-250 di ml tsa 0,9% sodium chloride. Tharollo e tsamaisoa ke lerotholi, ka methapo. E sebelisoa hang ka letsatsi bakeng sa 300-600 mg bakeng sa libeke tsa 2-4. E latelang, o hloka ho fetohela kalafo ea molomo.

Sehlahisoa se na le photosensitivity, ho bolelang hore li-ampoules li tlameha ho tlosoa hang-hang pele li sebelisoa.

Ho molemo ho sireletsa sejana ka tharollo ho tloha leseli nakong ea infusion, ka mohlala, u sebelisa mekotla ea foil kapa e sireletsang bobebe. Tharollo e entsoeng e bolokiloe sebakeng se lefifi mme e sebelisoa lihora tse tšeletseng kamora ho itokisa.

Haeba ngaka e laetse tsela ea kalafo le Octolipen, ho bohlokoa ho nahana ka lintlha tse latelang:

1. lipoic acid e ka hloka liphetoho litekanyetso tsa lithethefatsi tse ling le lihlahisoa tsa lijo,
2. haeba moriana o kenyelelitsoe ho thibelo e felletseng le kalafo ea lefu la tsoekere, ho bohlokoa ho lekola palo ea tsoekere maling e sebelisa glucometer, ho etsa liphetoho ka tekanyo ea li-hypoglycemic agents.
3. Sesebelisoa se sebetsang sa lithethefatsi se ts'oana le ts'ebetso ho livithamini tsa B, empa ha se tlatsetso ea vithamine. Ho sebelisa sehlahisoa ntle le ho buisana le ngaka ho ka mpefatsa mathata a bophelo bo botle.

Ketso ea pharmacological

Lipoic acid e thehoa kahare ho mmele nakong ea lits'oaetso tsa oxidative tsa acid ea keto. Matla a eona a ho felisa karabelo ea metabolic ea metabolism ho insulin e netefalitsoe. Lipoic acid e ama sebete ka ho toba, e leng bohlokoa ho lefu la tsoekere la mofuta oa 2.

Hona joale moriana o sebelisoa khafetsa botoneng haeba ho na le tlhahlobo ea lefu la tsoekere la mofuta oa 2 kapa ntle le tlhahlobo e joalo.

Lipoic acid e ama hantle litokelo tsa polokelo ea mafura a 'mele. Tlas'a tšusumetso ea asiti ena, libaka tsa mafura lia senyeha ebe ho lokolloa matla a mangata. Bakeng sa ho fokotsa boima ba 'mele, ho bohlokoa hape ho eketsa ts'ebetso ea' mele le ho latela lijo tsa kalafo.

Lipoic acid e nka lik'habohaedreite, empa li li fetisetsa eseng li-adipose tiske, empa ho li isa mesifa ea mesifa, moo li sebelisoang kapa li sebelisetsoang mosebetsi oa mesifa. Ka hona, moriana o sebelisoa ho fokotsa boima ba 'mele feela hammoho le lijo le lipapali.

Liphuputso tse ngata li bontša hore thioctic acid ha e na phello e tobileng ea anabolic.

Oktolipen e fokotsa ka nepo palo ea lactic acid liseleng tsa mesifa tse bōpang nakong ea boikoetliso. Motho o fumana monyetla oa ho mamella khatello ea maikutlo le nako e telele, e amang hantle boiketlo ba motho le ponahalo ea hae.

Lipoic acid e eketsa tsoekere ea tsoekere ka lisele tsa mesifa. Kahoo, le koetliso e nyane e tla etsa hore ho be le boemo bo tšoanang ka mor'a ho noa tee. Ho lokela ho hopoloa hore ha o ikoetlisa, metabolism e ka seleng e eketseha ka potlako, 'me ho hlaha mefuta e mengata ea litheko tsa mahala, tse sa aroloang habonolo ke lipoic acid.

Contraindication le lipontšo

Oktolipen e ngoletsoe batho ba nang le polyneuropathy e tsoetseng pele ea lefu la tsoekere le joala.

E boetse e bontšoa bakeng sa cirrhosis le neuralgia, tahi e nang le letsoai la tšepe e boima. Batho ba nang le maikutlo a phahameng ba lokela ho nka lithethefatsi ka hloko.

Ha o sebelisa meriana ena, ho ka ba le litlamorao tse latelang:

1. ho opeloa ke pelo, ho nyekeloa ke pelo, ho hlatsa,
2. ho hlaha hoa karohano e kulisang,
3. hypoglycemia

Matšoao a bosholu ba maikutlo ke:

Haeba ha u nka thioctic acid ka bongata ba 10 ho isa ho 40 g, matlapa a fetang 10 a 600 mg, kapa ka lethal dose le fetang 50 mg ka kilogram ea boima ba 'mele ho bana, ho hlaha ponahalo ea:

1. ho ferekana kelellong kapa ho ferekana ha kelello,
2. sehokahanyo se akaretsang,
3. Liphapang tse tebileng tsa tekano ea acid-msingi le lactic acidosis,
4. hypoglycemia (ho fihlela sebopeho sa komisi),
5. skeletal skeletal misuli,
6. hemolysis
7. DIC syndrome
8. masapo a mokokotlo
9. ho hloleha hoa litho tse ngata.

Haeba e 'ngoe ea lithethefatsi e sebelisoa' me ho hlaha lithethefatsi tse ngata, ho pepesetsoa sepetlele hanghang le ts'ebeliso ea mehato e thehiloeng ho melaoana e akaretsang haeba chefo ea kotsi e ka ba teng. O ka:

• ho hlatsa
• hlatsoa mpa
• nka mashala a sebetsang.

Phekolo ea ho ts'oaroa ka kakaretso, lactic acidosis le litlamorao tse ling tse behang bophelo kotsing li lokela ho etsoa ho latela melao ea tlhokomelo e matla mme e be sesupo. E ke ke ea tlisa sephetho:

1. hemoperfusion,
2. hemodialysis
3. Mekhoa ea ho filtara ha thioctic acid e hlohlorisoa.

Litšenyehelo le litekanyetso

Theko ea Oktolipen ha e holimo haholo. Litafole tse nang le 300 mg ea ntho ea mantlha li tla bitsa li-ruble tse 310.

Matlapa a Octolipen 600 mg a tla bitsa li-ruble tse 640. Lifekthering, u ka fumana alpha lipoic acid ka boeona. E theko e nyane - ke li-ruble tse 80 feela. Theko ea Tiolept e batla e le li-ruble tse 600, Tiogamm e bitsa li-ruble tse 200, Espa-lipon - li-ruble tse ka bang 800.

Mokhoa ha o fapana ka ho sebetsa mme o ka nkeloa sebaka ke o mong:

1. Tiolepta
2. Berlition,
3. Lipothioxone
4. Alpha lipoic acid,
5. Tiogamma
6. Thioctacid
7. Lipamide
8. Neuro lipone
9. Espa lipon
10. Thiolipone.

E atileng ka ho fetisisa, joale ke sethethefatsi Neyrolipon, ke mokhoa o motle bakeng sa Oktolipen.

Thioctic acid e teng ka tharollo ea Thioctacid, 'me thioctate trometamol e sebelisoa phetolelong ea matlapa.

Thioctacid ke lithethefatsi tsa metabolic tse thusang ho fokotsa lipontšo tsa lefu la tsoekere le joala le noopropathy.

• antioxidant
• hypoglycemic,
• hepatoprotective effect.

Thioctacid fetisa ts'ebetso ea metabolic 'meleng, e leng bohlokoa ho lefu la tsoekere la mofuta oa 2.

Ho na le mefuta ea litekanyetso:

Karolo e ka sehloohong ea moriana ke antioxidant ea mehleng. Ho ba teng ha ntho ea 'mele ho fana ka:

1. Ho tlosa tsoekere,
2. humanization of trophic neurons,
3. ts'ireletso ea lisele ketsong ea chefo,
4. ponahatso e fokotsang ea lefu lena.

Antioxidant ena ka tloaelo e ba teng 'meleng ka tekanyo e nepahetseng,' me e ts'ehetsa tšebetso ea eona e tloaelehileng.

Ntho e sebetsang e fumanehang ka har'a moriana oa Thioctacid e kenella ka potlako le ka botlalo, 'me e batla e tsoa' meleng ho isa halofo ea hora. Empa ts'ebeliso ea lithethefatsi ka lijo e ama ho amoha ntho ea mantlha. Bioavailability ke 20%.

Ha e le hantle, metabolism e phethoa ka oxidation le conjugation. Ho tlosoa ha bongata ba lithethefatsi ho etsoa ke liphio. Thioctacid hangata e fuoe li-neuropathies tsa lefu la tsoekere.

Setlhare se joalo se boetse se laetsoe li-pathologies tsa sebete. Mohlala, pheko e fanoe ho tsoa ho:

• cirrhosis
• hepatitis e sa foleng
• mafura a senyehileng,
• fibrosis.

Thioctacid e etsa hore ho khonehe ho tlosa phello e chefo e fetohileng litšepe.

Theko ea lithethefatsi ka mokhoa oa li-ampoules ke li-ruble tse 1,500, matlapa a theko e phahameng ho tloha ho li-ruble tse 1,700 ho isa ho tse 3 200.

Fumana qeto ea hore na ho molemo ke eng: Thioctacid kapa Oktolipen, ngaka e eang teng e tla thusa. Melemo ea lipoic acid bakeng sa lefu la tsoekere e tla akaretsoa ka video sehloohong sena.

Sebopeho le mofuta oa tokollo

Octolipene ka ampoules ke boitokisetso bo hlophisitsoeng bo reretsoeng ho hlophisoa ha tharollo bakeng sa tsamaiso ea methapo. Ponahalo ea tsepamiso ke mohloa o hlakileng o botala bo bosehla.

Millilita e le 1 ea moriana o na le asiti e sebetsang ea thioctic (alpha-lipoic) ka bongata ba 30 mg, 1 ampoule e na le 300 mg ea ntho e sebetsang.

Lisebelisoa tse thusang: ethylene diamine, edetate ea disodium, metsi a qhibilihileng.

Foromo ea tokollo: li-ampoules tse tsoang khalase e lefifi, bophahamo - 10 milliliters. Ho paka - mekotla ea likarete, ka paketeng e le 'ngoe ea li-ampoule tse 5.

Hape, lithethefatsi li hlahisoa ka mefuta e meng - Oktolipen li-capsules tse 300 le matlapa a Oktolipen 600.

Mofumahali

Ka tsamaiso e kenang ea tharollo ea tharollo, khatello e kholo ke 25-38 μg / ml, AUC e ka ba 5 μg h / ml. V_d - boholo ba 450 ml / kg.

Ntho e sebetsang - asiti ea thioctic e putlama ho metabolites sebeteng ka ho tšela oxidation le lehlakore. Alpha lipoic acid le metabolites ea eona li hlahisoa ke liphio ka bongata ba 80-90%. Bophelo ba halofo ke metsotso e 20-50. Tlhahiso ea plasma ka botlalo ke li-milliliters tse 10-15 ka motsotso.

Octolipen e laetsoe maemong a latelang:

• diabetesic polyneuropathy,
• lekhoba la joala.

Litlamorao

Tšebeliso ea moriana o ka baka litlamorao:

• karabelo - lintho tsohle tse ka u utloisang bohloko - urticaria le lekhotla la letlalo, lintho tse etsahalang maemong a itseng tse amanang le ho ts'oaroa ha ts'abo ea anaphylactic,
• lehlakoreng la metabolism - nts'etsopele ea matšoao a hypoglycemia, e amanang le ho monya tsoekere e ngata,
• ka lehlakoreng la tsamaiso ea methapo e bohareng - lits'oants'o le diplopia (li etsahala hangata ka tharollo ea methapo),
• ho tsoa tsamaisong ea mali a marang-rang - hemorrhages e hlahang kahara lera le ka hare la letlalo, thrombocytopathy, hemorrhagic rash, hammoho le thrombophlebitis,
• ba bang - khatello e matla ea ho kena-kenana le eona, ponahalo ea ho imeloa hloohong, ho hema ka thata, matšoao a tšoanang a ka etsahala ka ho kenyelletsoa ha tharollo ea infusion kahare.

Litlamorao tse thathamisitsoeng li itlhahela ka bobona.

Litaelo tse khethehileng

Ho bakuli ba nang le lefu la tsoekere, ho hlahlojoa khafetsa ke tsoekere ea mali ho hlokahala, haholo-holo qalong ea kalafo. Maemong a mang, ho fokotsa tekanyetso ea li-agents tsa hypoglycemic hoa hlokahala.

Nakong ea kalafo, hoa hlokahala ho hana ka tieo ho noa lino tse tahang, hobane ethanol e fokotsa ts'ebetso ea kalafo ea thioctic acid.

Lipehelo tsa Maemo a Phomolo ea meriana

Setlhare ke ngaka.

Theko ea lithethefatsi Okolipen ho ampoules e fapana ho isa ho li-ruble tse 400 ho isa ho tse 470, litšenyehelo li ipapisitse le k'hemiste e itseng moo u ka rekang lithethefatsi, hammoho le sebaka.

Analogues ea lithethefatsi Okolipen:

• Berlition 600,
• Berlition 300,
• Espa lipon
• Neuroleipone.

Ka tlase o ka tlohela tlhahlobo ea hau mabapi le lithethefatsi Oktolipen.

Lingoloa tse ling tse amanang:

Oktolipen ea lefu la tsoekere: litaelo le litlhahlobo: 3 maikutlo

Ke qetile lilemo tse 'maloa ke nka Oktolipen,' me ke nka mofuta oa batho ba thelisang marang-rang habeli ka selemo, 'me ho fanoa ka lefu la tsoekere ka mor'a lefu leo. Setlhare se a nthusa, ke thabile ka phello. Joale ke tlo etsa tsela e latelang ea ba oang, ka tsela eo, Oktolipen o sebelitse 'mele oa ka mme ka tsela ena - boima bo feteletseng bo fokotsehile, takatso ea ka ea lijo e se e tloaelehile.

Ke ile ka abeloa Oktolipen ka mor'a lefu la tsoekere le hlahisang nts'etsopele ea lefu la tsoekere. Kamora ho hlahisoa ha tharollo e kenang, ke ikutloa ke le betere, ke tsepamisitse maikutlo, ke le mafolofolo haholoanyane. Ke utloa eka metabolism e ea ntlafala, ha e ntse e theola boima ba 'mele hantle. Ke nka le lithethefatsi tsa hypoglycemic, empa ngaka e ile ea khetha litekanyetso ka nepo, ka hona, ha ke hlaheloe ke litla-morao.

Kameho ea ts'ebeliso ea lithethefatsi e ile ea bonoa feela ka mor'a libeke tse 2-3, boemo bo ile ba ntlafala hanyane, empa ha ho letho le fetohileng haholo. Mohlomong sethethefatsi se itseng ha se lumellane le nna, ke tla batla sethethefatsi se seng se nang le phello e tšoanang.

Sokolla foromo le sebopeho

• li-capsules: size No. 0, opaque, gelatin e thata, 'mala o mosehla, likhalase tsa likotlo ke' mala o mosehla o mosehla kapa o mosehla o nang le lipeipi tse tšoeu tse 10 (li-pcs tse 10. lipaketeng tsa blister, ka mekotleng ea 3 kapa 6 ea pakete).
• matlapa a koahetsoeng ka filimi: biconvex, 'mala o mosehla kapa o mosehla, oval, ka lehlakoreng le leng o kotsing, ho kink - ho tloha' mala o mosehla ho ea mosehla (li-pcs tse 10. ka marang-rang, ka lebokoseng la mekotla ea 3, 6 kapa 10 sephutheloana
• tsepamisa mohopolo ha ho etsoa tharollo ea motsoako: mokelikeli o hlakileng o botala bo bosehla (10 ml ka bongata ba khalase e lefifi, li-ampoules tse 5 ka moqomo o moputsoa, ​​ka mokotleng oa karete e le 'ngoe kapa tse peli.

Sekhahla sa 1 capsule Okolipen:

• ntho e sebetsang: thioctic (α-lipoic) acid - 300 mg,
• likarolo tse ling: setlhare sa pregelatinized, magnesium stearate, calcium hydrogen phosphate (calcium phosphate disubstituted), aerosil (colloidal silicon dioxide),
• capsule shell: dae letsatsi le likele lero (E110), quinoline mose (E104), gelatin ea bongaka, titanium dioxide (E171).

Sebopeho sa tafole e le 'ngoe e koahetsoeng ka filimi e le' ngoe, Okolipen:

• ntho e sebetsang: thioctic (α-lipoic) acid - 600 mg,
• likarolo tse ling: hyprolose (hydroxypropyl cellulose), hyprolose e tsoang sebakeng se tlaase (hydrxypropyl cellulose), magnesium stearate, colloidal silicon dioxide, croscarmellose (croscarmellose sodium),
• filimi ea ho etsa lifilimi: Opadry mose (OPADRY 03F220017 Yellow) macrogol 6000 (polyethylene glycol 6000), hypromellose (hydroxypropyl methylcellulose), talc, titanium diode, dae oxide e sootho (E172), aluminium varnish e thehiloeng holima quinoline (E104).

Sebopeho sa 1 ml ea Octolipen tsepamisa maikutlo:

• ntho e sebetsang: thioctic (α-lipoic) acid - 30 mg,
• likarolo tse ling hape: disodium edetate (letsoai la disodium la ethylenediaminetetraacetic acid), ethylenediamine, metsi bakeng sa ente.

Mofumahali

Thioctic acid (α-lipoic acid) e thehoa 'meleng nakong ea ha oxidative decarboxylation ea li-acid tsa α-keto e le ea "antioxidants" ea endo native. E fana ka tlamo ea li-radicals tsa mahala, e thusa ho khutlisetsa maemo a marang-rang a glutathione mme e eketsa ts'ebetso ea superoxide dismutase, e ntlafatsa li-neurons tsa trophic le axonal conduct. Ho ba coenzyme ea mitochondrial multenzyme complexes, ntho e nka karolo ho oxidative decarboxylation ea pyruvic acid le α-keto acid.

Ka lebaka la tšusumetso ea lithethefatsi, ho na le keketseho ea boemo ba glycogen bokong le ho fokotseha ha tsoekere maling le hammoho le ho hlola khatello ea insulin. Mofuta oa ketso ea biochemical ea thioctic acid e tšoana le livithamini tsa sehlopha sa B.

Ntho ena e tloaetse metabolism ea lipid le carbohydrate, e sebetsa metabolism ea cholesterol, e bonts'a phello ea lipotropic, e ntlafatsa ts'ebetso ea sebete, e bonts'a phello ea detoxifying nakong ea tahi, ho kenyelletsa le chefo ka letsoai le lengata la tšepe.

Nahanela tharollo ea infusion

Ho fumana tharollo ea infusion, ho khothalletsoa hore ho kenngoe moriana o matla oa 300-600 mg (ampoules ea 1-2) ka 50-250 ml ea tharollo ea soton sodium chloride (0,9%). Tharollo e lokiselitsoeng e lokela ho fanoa ka methapo e le 'ngoe ka letsatsi ka tekanyo ea 300-600 mg bakeng sa libeke tse 2-4. Kamora nako, ba fetoha pheko ea molomo.

Kaha Oktolipen o tsotella leseli, li-ampoules tse nang le mohopolo li hloka ho tlosoa polasetiking hang feela pele li sebelisoa. Nakong ea infusion, ho boetse ho molemo ho sireletsa vial ka tharollo e lokiselitsoeng ho tloha leseli u sebelisa mekotla ea aluminium foil kapa mekotla e senang khanya. Tharollo e felileng e lokela ho bolokoa sebakeng se sirelelitsoeng leseli, eseng ho feta lihora tse 6 ho tloha ka letsatsi la ho lokisa.

Bongata

Matšoao a ho ata ha thioctic acid e ka ba maloetse a latelang: ho hlatsa, ho nyekeloa ke hlooho, ho opeloa ke hlooho, maemong a tebileng ha u sebelisa litafole tse fetang 6 g ho batho ba baholo le ho feta 0,05 g / kg ya boima ba mmele ho bana - ho ba le letsoalo le ferekaneng, ho ferekana kelellong, psychomotor ho ruruha, hypoglycemia (ho fihla ho komisi), ho ferekana ho matla ha tekano ea acid-msingi le lactic acidosis, hemolysis, le skosis ea mesifa ea methapo, khatello ea ts'ebetso ea masapo, ho hasanya intravascular coagulation syndrome (DIC), polyorganorgan Single hloleha.

Haeba ho na le lipelaelo tsa ts'ebetso e feteletseng ea Okolipen, ho hlokahala sepetlele ka tšohanyetso le mehato e tloaelehileng e khothalletsoang chefo ea kotsi, ho kenyelletsa ho hlatsa, ho hlatsa ka mpeng, ho nka mashala a sebetsang, le kalafo ea matšoao. Mekhoa ea ho li-filtara ka ho felisoa ka thata ha thioctic acid, hemoperfusion le hemodialysis ha e na thuso. Motsoako o tobileng ha o tsejoe.

Bokhachane le pelehi

Ho latela litaelo, Oktolipen nakong ea kemolo e tšoaetsanoa ka lebaka la ho haella ha tlhaiso-leseling ea kliniki mabapi le ts'ebeliso ea thioctic acid nakong ena.

Nakong ea lithuto tsa bosholu ba ho ba le bana, menyetla ea ho ba le bokhoni ba ho ba le bana le litlamorao tsa lithethefatsi ha lia ka tsa bonahala.

Nakong ea kanyeso, kalafo le sethethefatsi e hanyetsoa, ​​kaha ha ho na data ea ho kenella ha eona ka lebese la matsoele.

Litlhahlobo mabapi le Oktolipen

Litlhahlobo mabapi le Oktolipen li ntle haholo. Bakuli ba hlokomela litholoana tse ntle tse tsoang ho tšebeliso ea lithethefatsi kalafong ea radiculopathy, lefu la tsoekere le polygurathy, hape e le hepatoprotector. Ho latela maikutlo, moriana o thusa ho fokotsa tsoekere ea mali le ho theola boima ba 'mele. Ho na le litlaleho tse ngata tseo ho tsona bakuli ba bonts'ang hore ketso ea Octolipen ha e sebetse ho feta ea analogue ea Berlition, 'me litšenyehelo li tlase haholo.

Likotsi tsa sethethefatsi (haholo-holo sebopeho sa litafole) li kenyelletsa nts'etsopele ea maikutlo a mabe, haholo-holo ho tsoa mokokotlong oa mpa.

Theko ea Oktolipen libakeng tsa meriana

Theko ea Oktolipen e ipapisitse le mofuta oa tokollo ea moriana mme e ka ba:

• Li-capsules tsa Octolipen 300 mg (li-pcs tse 30 ka pakete) - li-ruble tse 320-350,
• matlapa a koahetsoeng ka filimi, Oktolipen 600 mg (likhomphutha tse 30 ka pakete e le 'ngoe) - li-ruble tse 650-710,
• tsepamisa mohopolo bakeng sa ho hlophisoa ha tharollo ea inftate ea Oktolipen 30 mg / ml (10 ampoules ea 10 ml) - li-ruble tse 400-430.

Oktolipen: litheko tsa litlhare tsa marang-rang

Okolipen 300 mg senepe sa 30 likhomphutha.

OCTOLIPEN 30mg / ml 10ml 10 likhomphutha. tharollo ea infusion tsepamisa mohopolo

OCTOLIPEN 300mg 30 li-pcs. likhapha

Oktolipen 30 mg / ml tsepamisa mohopolo bakeng sa tharollo ea infusion 10 ml 10 likhomphutha.

Oktolipen 300 mg 30 likhahla

Oktolipen konc.d / inf. 30mg / ml 10ml n10

Konkreite ea Oktolipen bakeng sa inf 30 mg / ml 10 ml 10 amp

Letlapa le kopantsoeng le lifilimi tsa Okolipen 600 mg 30 likhomphutha.

OCTOLIPEN 600mg 30 li-pcs. matlapa a koahetsoeng ka filimi

Sebaka sa Oktolipen. p.p.o. 600mg n30

Matlapa a Oktolipen 600 mg 30

Oktolipen tbl p / pl / o 600mg No. 30

Thuto: Univesithi ea bongaka ea pele ea bongaka ea Moscow State e reheletsoeng ka I.M. Sechenov, ngaka e ikhethang "General Medicine".

Tlhahisoleseling mabapi le lithethefatsi e akaretsoa ka kakaretso, e fanoa molemong oa tlhahisoleseling mme ha e nke sebaka sa litaelo tsa semmuso. Ho ikoetlisa ho kotsi bophelong!

Bo-rasaense ba tsoang Univesithing ea Oxford ba ile ba etsa lipatlisiso, 'me ka nako eo ba fihlela qeto ea hore meroho e ka ba kotsi bokong ba motho, kaha e lebisa ho fokotseha ha boima ba eona. Ka hona, bo-rasaense ba khothaletsa hore ba se ke ba khetholla lihlapi le nama ka botlalo lijong tsa bona.

Ho 5% ea bakuli, "antidepressant clomipramine e baka" orgasm.

Linoko tse 'ne tsa chokolete e lefifi li na le likhalori tse ka bang makholo a mabeli. Kahoo haeba u sa batle ho phela hantle, ho molemo hore u se ke ua ja li-lobules tse fetang tse peli ka letsatsi.

Ka ho etela khafetsa betheng ea letlalo le lecha, monyetla oa ho tšoaroa ke kankere ea letlalo o eketseha ka 60%.

Ho latela liphuputso, basali ba noang likhalase tse 'maloa tsa biri kapa veine ka beke ba na le menyetla e eketsehileng ea ho tšoaroa ke mofetše.

Batho ba tloaetseng ho ja lijo tsa hoseng kamehla ha ba na monyetla oa ho ba motenya haholo.

Lefu le sa tloaelehang haholo ke lefu la Kuru. Ke baemeli ba morabe oa Fore New New New ba kulang le eena. Mokuli o shoa ka lebaka la litšeho. Ho lumeloa hore sesosa sa lefu lena se ja kelello ea motho.

Moriana oa ho khohlela "Terpincode" ke o mong oa baetapele ba rekisang, eseng ho hang ka lebaka la thepa ea bona ea bongaka.

Le ha pelo ea motho e sa otla, o ntse a ka phela nako e telele, joalo ka motšoasi oa litlhapi oa Norway Jan Revsdal. “Enjene” ea hae e ile ea emisa lihora tse 4 ka mor'a hore motšoasi oa litlhapi a lahlehe ebe o robala lehloa.

Basali ba bangata ba khona ho natefeloa ke ho nahanisisa ka 'mele oa bona o motle ka seiponeng ho fapana le ho etsa thobalano. Kahoo, basali, loanang ka kutloano.

Libaktheria tse limilione li tsoaloa, li phela 'me li shoa ka mpeng ea rona. Li ka bonoa feela ka tekanyo e phahameng, empa haeba li ka kopana, li ne li tla lekana ka senoelo sa kofi se tloaelehileng.

Ho na le li-syndromes tsa bongaka tse khahlang haholo, tse kang ho kenella ha lintho. Ka mpeng ea mokuli a le mong ea tšoeroeng ke lefu lena lena, ho ile ha fumanoa lintho tse 2500 tse tsoang ka ntle.

Mala a motho a etsa mosebetsi o motle ka lintho tsa kantle ho naha ntle le ts'ebetso ea bongaka. Jusi ea ka mpeng e tsebahala ho qhibiliha le lichelete tsa tšepe.

Qalong lithethefatsi tse ngata li ne li rekisoa ka lithethefatsi. Ka mohlala, qalong heroin e ile ea rekisoa e le moriana oa khohlela. Mme cocaine e ile ea khothalletsoa ke lingaka e le mokhoa oa ho ikoetlisa le mokhoa oa ho eketsa mamello.

Haeba sebete sa hau se khaotsa ho sebetsa, lefu le ne le tla ba teng ka mor'a letsatsi.

Polyoxidonium e bua ka lithethefatsi tsa immunomodulatory. E sebetsana le likhokahano tse ling tsa sesole sa 'mele, ka tsela eo e kenya letsoho kholisong ea.