CLINDACIN CANDLE

Clindacin, ho kenyelletsa le motsoako o sebetsang lincosamide lithibela-mafu – clindamycinke pheko ea lehae e sebelisoang ho phekola mafu a basali gardnerellosis (vaginosis) ea tlhaho ea baktheria. Mochine oa ts'ebetso oa mefuta ea litekanyetso tsa lithethefatsi (tranelate, li-suppositories) e reretsoe ho senya lits'ebetso tsa protheine ea intracellular seleng ea microbial, e etsahalang boemong ba karolo e kholo ea 50S ribosomal subunit.

Ketso ea ho bonahatsa clindamycin e lekane Methapong e mahareng, ts'ebetso ea "bacteriostatic" ea ts'ebeliso ea litlamorao ha e bapisoa le ba bangata likokoana-hloko. Bakeng sa litekanyetso tse phahameng clindamycin e bonts'itsoeng ke ketso ea bactericidal e etselitsoeng ho timetsoa ha ba bang likokoana-hloko.

Ketsahalo ea mantlha clindamycin bonoa mabapi le likokoana-hlokoe lebisang sebopeho bacteric vaginosiskenyeletsa: Mobiluncus spp. (mobilunkus) Gardnerella vaginalis (gardnerella vaginalis) Bacteroides spp. (bacteroids) Peptostreptococcus spp. (peptostreptococcus) Mycoplasma hominis (mycoplasma hominis).

Ha e nahanele ho pepeseha clindamycin ke litsietsi Li-albida tsa Candida (thrush) le Trichomonas vaginalis (vagich trichomonas).

Intravaginal (kahare ho mpa) ente e le 'ngoe ea clindamycin ka tekanyo ea 100 mg e lebisa ho tsamaisoeng ea meriana e ka bang 4% (hoo e ka bang 4 mg). Cmax ea plasma ea clindamycin ke 20 ng / ml.

Litlamorao

Bakuli ba bang ba nang le ts'ebeliso ea clindacin ba ile ba ikutloa ba ntlafatso ea litla-morao tse mpe, ho kenyeletsa: ho hlohlona ka botšehalingthuto makhopho a maculopapularketsahalo urticariantshetsopele cervicitis kapa colpita (vaginitis) vulvovaginal ho tenehamaikutlo ho tuka.

Ho tsoa ts'ebetsong ea hematopoietic maemong a sa tloaelehang, ho ile ha bonoa se latelang: thrombocytopeniae fetoloe leukopenia, eosinophilia, neutropenia, agranulocytosis.

Tabeng ea tlhahlobo ea bohlokoa ea systemic ea clindamycin, ponahatso ea litla-morao tsa eona tsa ts'ebetso li ka khoneha, ho kenyelletsa le ho etsoa ha pseudomembranous enterocolitis (ka seoelo).

Clindacin tranelate, litaelo tsa tšebeliso

Clindacin tranelate e etselitsoe tšebeliso ea intravaginal ho sebelisoa sesebelisoa se ikhethileng, sa nako e le 'ngoe se kenyelitsoeng ka har'a sehlahisoa sa sehlahisoa sa meriana. Motsoako o le mong o khothalelitsoeng oa tranelate letsatsi le letsatsi ke 100 mg clindamycin (bophahamo ba mokopi ea tlatsitsoeng ka botlalo). Ho hlahisoa ha moriana ho etsoa hantle mantsiboea (pele a robala). Nako ea thupelo ea kalafo, joalo ka molao, e nka matsatsi a 3 ho isa ho a 7.

Ts'ebeliso ea mokopi

Bakeng sa dosing e loketseng le tsamaiso ea tranelate ka hara botshehadi, ho kgothaletswa ho sebedisa kopo tse lahliloeng tse ka sephutheloaneng le lithethefatsi le ho latela mokhoa oa ts'ebeliso, e leng:

• tlosa senepe se sirelletsang ka mothong oa tranelate,
• screw sebakeng sa kopo kopo ya polasetiki,
• sutumetsa pheletso e ka lehlakoreng la tube ho tlatsa mokopi ka botlalo (mokopi o nkoa a tlatsitsoe ka botlalo ha piston ea eona e ikemetseng e fihla setopong),
• e robetse mokokotlong oa hao, kenya setsi sa tšebetso ka hara botshehadi ka botebo kamoo o ka khonang,
• ka bonolo sutumetsa mokopi ka piston ho fihlela e se na letho,
• tlosa ka hloko setsi se sebelisitsoeng ka hara botšehali 'me u se lahle.

Likerese clindacin, litaelo tsa tšebeliso

Li-supplement tsa Clindacin le tsona li sebelisoa intravaginally, ka tsamaiso e le 'ngoe ea letsatsi le letsatsi ea sephutheloana sa pele, haholo-holo ka shoalane (pele ho robala). Nako ea thupelo ea kalafo, joalo ka molao, e nka matsatsi a 3 ho isa ho a 7.

Bakeng sa tšebeliso e nepahetseng ea lithethefatsi, tlatsetso e le 'ngoe e lokela ho lokolloa polasetiking ea kantle ka ho seha filimi e sirelletsang likhutlong tsa kerese. Ebe boemong ba supine, kenya supplementory ka hara botshehadi ka botebo kamoo o ka khonang.

Tšebelisano

Ha e kopantsoe le clindamycin, katleho ea li-aminoglycosides e ea matlafatsoa (Streptomycin), Rifampicin le Gentamicin.

Clindamycin ha e lumellane le Aminophylline, Erythromycin, Magnesium sulfate, Ampicillin, Calcium calciumconconatetse tsoang diphenylhydantoin le barbiturates.

Litlamorao tsa clindamycin li eketsa boikhathollo ba mesifa ka lebaka la ho pepeseha n-anticholinergics.

Mokhoa oa kopo

Mabone Clindacin sebetsa: kahare. Pele o sebelisoa, suppository e le ngoe e tsoa ho sephutheloana sa contour, kamora ho khaola filimi kahare ho sephutheloana, e hlahisoa, haeba ho khoneha, e kenella kahare ka hara botshehadi.
1 suppository 1 nako ka letsatsi, hang pele ho robala bakeng sa matsatsi a 3-7 ka tatellano.

Khokahano le sebopeho sa moriana

Clindacin e fumaneha ka mokhoa oa liphutheloana bakeng sa tsamaiso ea botšehali ka lipaketeng tsa likarolo tse 3 ka lebokoseng la karete. Moriana o tsamaea le litaelo tse qaqileng.

Sesebelisoa sa mantlha sa motsoako ke clindamycin phosphate, e ngoe le e 'ngoe ea tlatsetso e na le 100 mg ea ntho ena. Ho hlophisoa ha likerese ho kenyelletsa le likarolo tse 'maloa tse thusang.

Melemo ea pharmacological

Clindacin ke ea lithibela-mafu tse tsoang sehlopheng sa lincosamides. Ntho e sebetsang ea sethethefatsi e bonts'a ts'ebetso e phahameng ea kalafo mabapi le mefuta e mengata ea likokoana-hloko tsa ts'oaetso. Ketso ea moriana ke bacteriostatic, ke hore, "clindamycin phosphate," e leng karolo ea tlatsetso, e thibelang kholo le tsoalo ea lisele tsa pathogen ea pathological ka ho thibela ho hlophisoa ha liprotheine tsa sele ea microbial.

Setlhare se sebetsa hantle haholo khahlanong le staphylococci, streptococci, corynebacteria, mycoplasmas, peptococci, clostridia. Pele a fana ka liphutheloana, mosali o lokela ho sebelisa li-bacteric le bacterioscopic inoculation tsa sephiri ho tseba botebo ba pathogen ho lithibela-mafu.

Motsoako ona o sebelisoa ho ts'ebetso ea gynecological bakeng sa kalafo ea baktheria ea vaginosis e bakoang ke likokoana-hloko tse ikhethileng ho clindamycin.

Contraindication

Pele a qala kalafo ka moriana, mokuli o lokela ho etela ngaka ea mafu a basali, ho etsa liteko le ho bala litaelo tse hoketsoeng ka hloko. Li-suppositories li hanyetsanoa ho bakuli ba nang le hypersensitivity ho clindamycin kapa likarolo tse thusang tse etsang lithethefatsi, basali baimana le batho ba nang le neoplasms e mpe ea litho tsa kahare.

Sebelisa nakong ea bokhachane le pelehi

Ka trimester ea pele ea bokhachane, li-supplement tsa clindacin ha li fuoe kalafo ho bo-mme ba lebelletsoeng. Sena se bakoa ke tlhaiso-leseling e sa lekaneng mabapi le litlamorao tsa polokeho ea clindamitacin kholisong ea bokhachane, ho feta moo, libekeng tse 12 tse qalang, litho tsohle le litsamaiso tsa ngoana ea e-s'o hlahe li thehiloe, mme phello ea lithethefatsi e ka ama ts'ebetso ena hampe.

Karolong ea bobeli ea boraro le ea boraro ea bokhachane, ts'ebeliso ea li-supplement e ka khoneha feela ho latela lipontšo tse tiileng tlasa taolo ea ngaka maemong a hore phaello e ka bang teng ho mme ea lebelletsoeng e tla ba e phahameng haholo ho feta kotsi e ka bang teng ho lesea.

Litlamorao

Ka kakaretso, moriana o mamelloa hantle ke bakuli, leha ho le joalo, ho batho ba nang le kutloisiso e eketsehileng ea motho ka mong ho clindamitacin, maikutlo a latelang a mabe a ka hlaha:

• Karolong ea litho tsa sistimi ea ho ikatisa - nts'etsopele ea ts'oaetso ea methapo ea ka popelong, vaginitis, colpitis,
• Ho tsoa lithong tsa hemopoietic - ho fokotsa palo ea leukocytes, neutropenia, eosinophilia, thrombocytopenia, agranulocytosis,
• Boitšoaro ba lehae - ho chesa, ho hlohlona ka hara botshehadi, bohloko le ho hloka boroko,
• Tsamaiso ea acidic ea moriana e tlase, empa maemong a sa tloaelehang e ka lebisa ho nts'etsopele ea pseudomembranous enterocolitis.

Litaelo tse khethehileng

Nakong ea kalafo ka litlatsetso tsa botšehali, ho khothalletsoa ho hana likamano tsa botona le botšehali.

Kaha nakong ea kalafo ka li-supplement tsa moriana ho mosali, litšila tsa botšehali li ka matlafatsoa, ​​lipilisi tse lahloang tsa bohloeki li lokela ho apesoa bakeng sa boiketlo le bohloeki.

Nakong ea ho ilela khoeli, kalafo ea lithethefatsi ha e etsoe. U lokela ho ema ho fihlela qetellong ea matsatsi a mahlonoko mme ke feela ka mor'a hore u qale ho qala kalafo.

Nakong ea bokhachane le pelehi

Ho ea ka litaelo tsa semmuso, lithuto tsa kliniki tsa polokeho ea clindacin ha boimana ho trimester ea pele ha ea ka ea etsoa, ​​mabapi le hore, ts'ebeliso ea eona nakong ena ha e khothalletsoe. Phekolo ea Clindacin bakeng sa basali nakong II le III trimester ea bokhachane e lumelletsoe feela maemong a tlisoang ke melemo ea kalafo e joalo ho mme, ho bapisoa le litlamorao tse mpe tse ka bang teng ho lesea.

Leha ho le joalo, ho gynecology ho na le tloaelo ea ho beha Clindacin ho II le III trimester ea bokhachanekaha ba bang tšoaetso ea botšehalika sebele hloka kalafo e joalo. Ha ho nahanoa ka litlhahlobo mabapi le sehlahisoa sena ka mokhoa oa tranelate, hammoho le litlhahlobo mabapi le litlatsetso nakong ea kemolo nakong ena, ho bohlokoa ho hlokomela hore maemong a mangata, kalafo e nang le Clindacin e ile ea lebisa ho feliseng lefu le tšoaetsanoang ntle le litlamorao tse mpe ho 'm'a le moimana.

Ho Ikhetholla ka Sebakeng se Holimo clindamycin ka lebese la 'm'a ea anyesang ha lea ka la ithutoa, mabapi le hore, morero oa lona nakong ea eng lebone ho ka etsahala feela ka papiso e ntle ea melemo ea kalafo e joalo ho mme ho bapisoa le likotsi tse ka bang teng bakeng sa lesea.

Litlhahlobo mabapi le Klindatsin

Boholo ba basali ba sebelisang moriana ona kalafo bacteric vaginosis, Ke siea litlhahlobo tse ntle mabapi le li-supplement tsa clindacin, ho kenyelletsa le bakuli ba qobelloang ho retelehela ho sethethefatsi sena ho ima ho II le III trimester. Litlhahlobo mabapi le tranelate ea Klindacin ha li ngata haholo, empa li ntle hape mabapi le ts'ebetso le polokeho ea moriana ona oa kalafo. Ho akaretsa maikutlo a akaretsang a bakuli mabapi le kalafo ea Klindacin bacteric vaginosis, ho bolokehile hore o ka e khothalletsa hore e sebelisoe ho latela lipontšo, empa feela kamora ho buisana le setsebi.

Theko ea Klindatsin hore na e ka rekoa kae

Ha ho bapisoa le lintho tse bapisoang le eona bakeng sa tšebeliso ea li-topical (ho kenyeletsa le litlolo tsa botšehali, litlolo, litlatsetso, likhakeletsi, joalo-joalo), litšenyehelo tsa clindacin li maemong a phahameng. Mohlala, theko Klindatsina likerese No. 3 e ka ba li-ruble tse 650 (ka ho fapana, likerese tse 6 li ka rekoa ka kakaretso bakeng sa li-ruble tse 1300). Theko Cryacin tranelate fapana pakeng tsa li-ruble tse 350-400 ka mothapo o le mong oa ligrama tse 20.

Boikutlo bo fapaneng

Sistimi ea Genitourinary: bohloko ba ka hara botshehadi, candidiasis ya ka hara botshehadi, ho se sebetse ka nako ya menstrual, ho nyekeloa ke botšehali, dysuria, pyelonephritis, tšoaetso ea vaginitis / bosaling.

'Mele ka kakaretso: tšoaetso ea fungal, bohloko ba ka mpeng, ho opeloa ke hlooho, bohloko ba ka mpeng, feberu, bohloko bo ka lehlakoreng, bohloko hohle 'meleng, edema ea lehae, candidiasis.

Phekolo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo.

Letlalo le li-membrane tsa mucous: ho hlohlona (eseng sebakeng sa ente), lekhopho, bohloko setsing sa ente, ho hlohlona (sebakeng sa ente).

Sebelisa nakong ea bokhachane kapa leboteng

Tšebeliso ea methapo ea kutlo ea "li-supplement tsa" "Clindamycin" phosphate ho basali ba baimana ka nako ea bobeli ea bokhachane, hammoho le ts'ebeliso ea kemiso ea "clindamycin" ho la bobeli le la boraro ha ea ka ea baka litlamorao.

Ho basali ba trimester ea pele ea bokhachane, sethethefatsi sena se lokela ho sebelisoa hafeela ho na le leseli le ke keng la latoloa.

Ha ho tsejoe hore na clindamycin e pepesitsoe lebeseng kamora ts'ebeliso ea methapo ea sethoathoa sa "trindamycin", ka hona, nakong ea kanyeso, moriana o ka fuoa feela ha moputso o lebelletsoeng ho mme o feta kotsi e ka bang teng ho lesea.

Bana ha ba sebelise lithethefatsi.

Likarolo tsa ts'ebeliso

Ts'ebeliso ea li-suppositories tsa botšehali ka clindamycin e ka lebisa nts'etsopele ea likokoana-hloko tse sa tsotelleng, ho kenyeletsa le tomoso.

Tšebeliso ea molomo le ea batsoali ka clindamycin e ka baka lets'ollo, 'me maemong a mang - colitis. Haeba, ha u sebelisa mefuta ea litekanyetso tsa clindamycin bakeng sa tsamaiso ea methapo ea methapo, ts'oaetso e matla kapa ea nako e telele e ba teng, setlhare sena se lokela ho hlakoloa, mekhoa e nepahetseng ea tlhahlobo e lokela ho etsoa mme kalafo e lokela ho khethoa haeba ho hlokahala.

Bakuli ba lokela ho lemosoa hore nakong ea kalafo ea li-supplement tsa vaginal tse nang le clindamycin, u se ke oa kena likamanong tsa botšehali, hape hape u se ke ua sebelisa mefuta e meng ea lihlahisoa tse etselitsoeng tsamaiso ea intravaginal (ka mohlala, li-tampons, lihlahisoa tsa douching).

Sehlahisoa se na le likarolo tse ka fokotsang matla a lihlahisoa tsa latex kapa rabara, joalo ka likhohlopo kapa li-diaphragms tsa botšehali. Ka hona, ts'ebeliso ea lihlahisoa tse joalo nakong ea kalafo le moriana ka mokhoa oa li-supplement tsa vaginal ha e khothalletsoe.

Hoo e ka bang 30% (6.5 - 70%) ea clindamycin e kenella tsamaisong ea kemiso kamora ts'ebeliso ea li-supplement tsa vaginal.