Tlhaloso le litaelo bakeng sa tšebeliso ea lithethefatsi Berlition

Berlition e fumaneha ka mefuta e latelang ea litekanyetso:

• Tsepamisa maikutlo bakeng sa tharollo ea infusion: botala bo bosehla, bo pepeneneng (Berlition 300: 12 ml ka har'a ampoule e khanyang ea khalase, li-ampoule tse 5, 10 kapa 20 ka har'a li-trouse tsa karete, 1 terakeng ea karete ea karete, Berlition 600: 24 ml ka li-ampoule tse khanyang tsa khalase, li-ampoule tse 5 lipulong tsa polasetiki, pallet e le ngoe ka lebokoseng la karete.
• Matlapa a koahetsoeng ka filimi: pota, biconvex, ka lehlakoreng le leng - kotsi, 'mala o mosehla, sefapanong ho bonahala sebopeho se sa bonahaleng (li-pcs tse 10.. Ka lithutsoana, lithutsoana tse 3,6.10 ka lebokoseng la karete ea karete).

Sesebelisoa sa mantlha se sebetsang ke thioctic acid:

• Ho 1 ampoule ea ho tsepamisa maikutlo - 300 mg kapa 600 mg,
• Letlapeng le le leng - 300 mg.

Mofumahali

Asiti ea Thioctic (alpha lipoic) ke antioxidant ea endo native ea ho sebetsa ka kotloloho (e sa kopaneng le tlamahano) le ketso e sa tobang. Ke ea sehlopha sa li-coenzymes tse amehang ho decarboxylation ea alpha-keto acid. Khemero ena e thusa ho theola tsoekere ea plasma le ho eketsa khatello ea glycogen, e fokotsa khatello ea insulin, e nka karolo taolong ea metabolism ea lipid le carbohydrate, hape e matlafatsa metabolism ea cholesterol.

Kaha thioctic acid e na le thepa ea antioxidant, e sireletsa liseleng hore e se ke ea senngoa ke lihlahisoa tsa eona tse senyehang, e thibela tlhahiso ea lihlahisoa tse tsoelang pele tsa li-protein tsa lisele tsa methapo, tse tsamaeang le lefu la tsoekere, li ntlafatsa phallo ea mali le methapo ea methapo, le ho eketsa phallo ea mmele ea glutathione antioxidant. Ho fana ka phokotso ea tsoekere ea mali maling a mali, karolo e sebetsang ea Berlition e ama metabolism e 'ngoe ea tsoekere ho tsoekere ea mellitus, e fokotsa ho bokellwa ha methapo ea methapo ea methapo ka mokhoa oa polyols mme ka lebaka leo, e fokotsa edema ea lithane tsa methapo.

Thioctic acid e kenella ho metabolism ea mafura, e lebisang keketseho ea biosynthesis ea phospholipids, haholo phosphoinositides, e lebisang ho tloaelehileng ha sebopeho se senyehileng sa membrane ea sele. Hape, ntho ena e ntlafatsa conduction ea methapo ea kutlo le metabolism ea matla, e u lumella ho tlosa litlamorao tsa chefo ea metabolites ea joala (pyruvic acid, acetaldehyde). Thioctic acid e thibela ho thehoa ha limolek'hule tse ngata tsa "radicals" ea oksijene, e felisang ischemia le endoneural hypoxia, e fokotsa matšoao a polyneuropathy, a hlahisoang ka maikutlo a ho ba le letsoalo, bohloko kapa ho chesa matsohong le litlamong. Kahoo, ntho ena e ntlafatsa metabolism ea lipid mme e tšoauoa ka phello ea neurotrophic le antioxidant. Ts'ebeliso ea thioctic acid ka mokhoa oa letsoai la ethylene diamine e lebisa ho theoheng ha litlamorao tsa litlamorao tse mpe tse ka bang teng.

Mofumahali

Ka tsamaiso ea methapo ea Berlition, palo e phahameng ea ntho e sebetsang ka plasma ea mali e ka ba 20 μg / ml metsotso e 30 kamora ho kenngoa, mme sebaka se ka tlas'a nako ea mahloriso ke hoo e ka bang 5 μg / h / ml. Thioctic acid e na le "pele feta" e amang sebete. Li-metabolites tsa eona li thehiloe ka lebaka la conjugation le oxidation ea ketane ea lehlakoreng. Bophahamo ba thomello ke hoo e ka bang 450 ml / kg. Tlhahiso ea plasma ka kakaretso ke 10-15 ml / min / kg. Thioctic asiti e epolloa ka liphio (80-90%), haholo ka sebopeho sa metabolites. Bophelo ba halofo ke metsotso e 25.

Litaelo tsa ho sebelisoa ha Berlition: mokhoa le litekanyetso

Hangata moriana o nooa hang ka letsatsi, hoseng, halofo ea hora pele ho lijo tsa hoseng. Matlapa a Berlition a ke ke a hlafuna le ho sithabetsoa. Tekanyetso ea letsatsi le letsatsi bakeng sa batho ba baholo ke 600 mg (matlapa a mabeli).

Setlhare ka mokhoa oa sekhahla, se kenelletsoeng ka tharollo ea 0,9% ea sodium chloride, se fanoa ka mokhoa o theohileng ka 250 ml bakeng sa halofo ea hora. Tekanyetso ea letsatsi le letsatsi bakeng sa bakuli ba baholo ke 300-600 mg. Ho hlahisoa ha Berlition kahare hangata ho na le libeke tse 2, ka mor'a moo mokuli a fetisetsoa lithethefatsi ka molomo.

Litaelo tse khethehileng

Nakong ea kalafo, o lokela ho tlohela tšebeliso ea lino tse nang le joala, hobane ethanol e fokotsa ts'ebetso ea thioctic acid.

Bakuli ba nang le lefu la tsoekere ba lokela ho lula ba lekola likhahla tsa tsoekere ea mali.

- Ja lihlahisoa tsa lebese, hammoho le litokisetso tsa magnesium le tšepe nakong ea kalafo e lokela hoba mots'eare.

Ka tsamaiso e kopaneng ea lithethefatsi ka li-agents tsa hypoglycemic le insulin, phello ea eona e ea ntlafala.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Boithuto mabapi le litlamorao tsa Berlition ka lebelo la karabelo ea psychomotor le bokhoni ba ho lemoha le ho hlahloba kapele maemo a sa tloaelehang ha li e-so tšoaroe, ka hona, nakong ea kalafo ka moriana, tlhokomelo e khethehileng e lokela ho nkuoa ha u khanna le ho etsa mefuta e kotsi ea mosebetsi e hlokang ho eketseha ha tlhokomelo le ho tsepamisa maikutlo.

Ho sebelisana le lithethefatsi

Kaha ho thehoa ha li-chelate complexes tsa thioctic acid ka tšepe ho ka khoneha, Berlition ha ea lokela ho laeloa hammoho le litokisetso tsa tšepe. Ho kopantsoe ha sethethefatsi le chisplatin ho fokotsa katleho ea morao.

Thioctic acid e kopana le limolek'hule tsa tsoekere, e etsa metsoako e rarahaneng eo ho hang e sa khone ho qhibiliha. Berlition e thibetsoe ho sebelisoa khahlano le semelo sa kalafo ka tharollo ea Ringer, dextrose, fructose le glucose, hammoho le tharollo e sebelisanang le disulfide le lihlopha tsa SH. Lithethefatsi li ntlafatsa phello ea hypoglycemic ea insulin le lithethefatsi tse ling tsa hypoglycemic ka ts'ebeliso ea tsona ka nako e tšoanang. Ethanol e fokolisa haholo ts'ebeliso ea bongaka ea Berlition.

Li-analogues tsa libopeho tsa Berlition ke Espa-Lipon, Oktolipen, Thiogamma, Lipothioxon, Thiolipon le Neuroleipone.

Tlhahlobo ea Berlition

Ho latela maikutlo, Berlition 300 le Berlition 600 ka mokhoa ofe kapa ofe oa litekanyetso (matlapa, ente) hangata li sebelisetsoa ho phekola bakuli ba nang le lefu la tsoekere le lefu la sebete. Ho feta moo, lithethefatsi li nkuoa li sa sebetse haholo hara bakuli feela, empa le maemong a bongaka. Maemong a 95%, kalafo e nang le Berlition e fana ka liphetho tse ntle, mme litlamorao tse mpe ha li hlile ha li eo. Empa ho lokela ho tsotelloa hore ke setsebi feela se lokelang ho beha moriana oa bongaka le ho ntlafatsa mofuta oa kalafo.

Contraindication

Ho latela litaelo, Berlition e ngolisitsoe ho:

• Ho se mamellane ha alpha lipoic acid kapa likarolo tse thusang tsa moriana,
• Tlas'a lilemo tse 18
• Bokhachane le pelehi.

Matlapa a Berlition 300 Oral a hanyetsoa bakeng sa kalafo ea bakuli ba nang le malabsorption ea glucose-galactose, ho haella ha lactase le galactosemia. Li-capslop tsa Berlition ha li hlahisoe ho bakuli ba nang le mamello ea fructose.

Tšebelisong ea Berlition, tlhokomeliso e lokela ho sebelisoa ho lefu la tsoekere. Haeba ho na le tlhoko ea ho sebelisa lithethefatsi bakeng sa sehlopha sena sa bakuli, glycemia e lokela ho hlahlojoa khafetsa.

Tekanyetso le tsamaiso

Berlition matlapeng le likhabaneng e behiloe kahare. Setlhare ha se khothalletsoe ho hlafuna kapa ho sefa ka nako ea ts'ebeliso. Tekanyetso ea letsatsi le letsatsi e nkuoa hang ka letsatsi, e ka bang halofo ea hora pele ho lijo tsa hoseng. Bakeng sa ho fihlella phello e matla ea kalafo, ho kgothaletswa ho latela ka tieo melao ea kamohelo e boletsoeng ho litaelo tsa Berlition.

E le molao, nako ea kalafo le Berlition e telele. Nako e nepahetseng ea kamohelo e khethoa ka bomong ke ngaka e eang. Tekanyetso ea moriana:

• Ka lefu la tsoekere la polyneuropathy - 600 mg ka letsatsi,
• Ka mafu a sebete - 600-1200 mg ea thioctic acid ka letsatsi.

Maemong a tebileng, ho khothalletsoa ho beha mokuli Berlition ka mokhoa oa tharollo ea infusion.

Berlition ka mokhoa oa ho tsepamisa mohopolo ha ho etsoa tharollo ea infusion e sebelisetsoa tsamaiso ea methapo. E le solvent, ho lokela ho sebelisoa feela chloride ea 0.9% ea sodium, 250 ml ea tharollo e lokisitsoeng e fanoa halofo ea hora. Tekanyetso ea moriana:

• Ka mofuta o matla oa lefu la tsoekere la polyneuropathy - 300-600 mg ea Berlition,
• Ho mafu a matla a sebete - 600-1200 mg ea thioctic acid ka letsatsi.

Mefuta ea botšehali ea lithethefatsi e etselitsoe kalafo, hore na nako ea eona ke likhoeli tse 0.5-1, kamora moo, e le molao, mokuli o fetisetsoa matlapeng kapa likhabaneng tsa Berlition.

Litlamorao

Tšebeliso ea Berlition e ka baka litlamorao tse latelang:

• Sistimi ea tšilo ea lijo: Ho hlatsa le ho nyekeloa hoa pelo, ho sokela kapa lets'ollo, phetoho ka tatso, matšoao a dyspeptic,
• Tsamaiso ea methapo ea kutlo le e bohareng: kamora ho kenella ka potlako mothapong, ho tsitsipana, ho ikutloa o le boima hloohong, diplopia,
• Ts'ebetso ea pelo: Hyperemia ea sefahleho le 'mele o holimo, tachycardia, maikutlo a ho tiea le ho utloa bohloko sefubeng,
• Allergies: lekhopho la letlalo, ho hlohlona, ​​eczema, urticaria.

Ka nako e 'ngoe, ka ts'ebetso e kenelletseng ea litekanyetso tse phahameng tsa lithethefatsi, ho ts'oaroa ha anaphylactic ho ka hlaha. Hape, nts'etsopele ea ho opeloa ke hlooho, ho tsekela, ho senyeha ha pono, ho hema hanyane, sephetho le thrombocytopenia ha li qhaloe.

Ho bakuli ba nang le polyneuropathy nakong ea pele ea kalafo le Berlition, ho ka ba le keketseho ea "presthesia" e tsamaeang le maikutlo a "liqhubu" tsa "goose".

Lipehelo le maemo a polokelo

Ho latela litaelo, Berlition e lokela ho bolokoa sebakeng se ommeng, se lefifi le se pholileng.

Ho tsepamisa mohopolo bakeng sa tharollo ea infusion ho na le bophelo ba rakafo ea lilemo tse 3. Ka foromo e felileng, tharollo ea infusion e ke ke ea bolokoa lihora tse fetang tse 6 (ha feela botlolo e sirelelitsoe letsatsing).

Matlapa a Berlition 300 Oral a na le bophelo bo habeli ba lilemo tse 2, li-capsule tse 300 tsa Berlition - lilemo tse 3, Berlition 600 - lilemo tse 2,5.

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