Bana le bacha ba ka tlase ho lilemo tse 18, ho ima, ho nyeka (nako ea ho anyesa), hypersensitivity ho lithethefatsi.

Ka hloko, fana ka lipilisi tsa moriana tsa lefu la sethoathoa (ho kenyeletsa nalane), lefu la sethoathoa, ho hloleha ha sebete, letšoao la ho lelefatsa nako ea QT.

Moxifloxacin

Moxifloxacin: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Moxifloxacine

Khoutu ea ATX: J01MA14

Motsoako o sebetsang: moxifloxacin (moxifloxacin)

Mohlahisi: Verteks AO (Russia), Hetero Labs Limited (India), PFK Alium, LLC (Russia), Virend International, LLC (Russia), Promomed Rus, LLC (Russia)

Nchafatso ea litlhaloso le foto: 11/22/2018

Litheko makaleng a litlhare: ho tloha li-ruble tse 396.

Moxifloxacin ke moemeli oa antibacterial oa bongata bo fapaneng ba ketso ea bactericidal.

Ketso ea pharmacological

Sebaka sa antimicrobial sehlopheng sa fluoroquinolones, se sebetsa ka bactericidal. E sebetsa khahlano le mefuta e fapaneng ea likokoana-hloko tsa gram-positive le gram-negative, anaerobic, acid e thibelang acid le atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. E sebetsa hantle khahlanong le mefuta ea libaktheria e hanyetsanang le beta-lactams le macrolides. E sebetsa khahlano le mefuta e mengata ea likokoana-hloko: gram-positive - Staphylococcus aureus (ho kenyelletsa le lintho tse sa ameheng methicillin), Streptococcus pneumoniae (ho kenyelletsa le mefuta e hananang le penicillin le macrolides), Streptococcus pyogene (sehlopha A), gram-negative - Haemophilus influenzae le mefuta e sa hlahiseng beta-lactamase), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (ho kenyelletsa le mefuta e hlahisang beta-non-beta-lactamase e hlahisang), Escherichia coli, Enterobacter cloacae, atypical Chlamydia pneumonia.

Litlamorao

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho opeloa ke mpa, ho nyekeloa ke pelo, lets'ollo, ho hlatsa, dyspepsia, botlaaseng, ho sokela, ho eketseha hoa ts'ebetso ea transaminase ea hepatic, ho kheloha ha tatso.

Ho tloha lehlakoreng la methapo ea methapo e bohareng le tsamaiso ea methapo ea methapo: ho tsekela, ho hloka boroko, ho tšoha, ho tšoenyeha, asthenia, hlooho ea hlooho, ho thothomela, paresthesia, bohloko ba leoto, makhopho, pherekano, khatello ea maikutlo.

Ho tsoa ho ts'ebetso ea pelo: tachycardia, edema ea potoloho, khatello e phahameng ea mali, palpitations, bohloko ba sefuba.

Karolong ea li-paramente tsa laboratori: ho fokotseha ha boemo ba prothrombin, keketseho ea mesebetsi ea amylase.

Ho tsoa ho tsamaiso ea hemopoietic: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, anemia.

Ho tsoa tsamaisong ea musculoskeletal: bohloko ba morao, arthralgia, myalgia.

Ho tsoa ts'ebetsong ea kemolo: vagi candidiasis, vaginitis.

Boitlhotlhollo bo tsoang ka bongata: lekhopho, ho hlohlona, urticaria.

Tšebelisano

Ka tšebeliso e tšoanang ea li-antacids, liminerale, li-multivitamine li sitisa ho kenngoa (ka lebaka la sebopeho sa li-chelate complexes ka li-cation tsa polyvalent) le ho fokotsa khatello ea lithethefatsi ho plasma (tsamaiso e le 'ngoe e khonahala ka karohano ea lihora tse 4 pele kapa lihora tse 2 kamora ho sebelisa moriana).

Ka kalafo le lithethefatsi ha ho ntse ho sebelisoa fluoroquinolones tse ling, nts'etsopele ea liphetoho tsa molumo oa litšoantšo e ka etsahala.

Ranitidine e fokotsa ho amoheloa ha moriana.

Lipotso, likarabo, litlhahlobo ho lithethefatsi Rotomox

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebeletsang e le sebaka sa boipiletso ba motho ho setsebi.

Mokhoa oa ho sebelisa lithethefatsi Rotomox 400?

Rotomox 400 ke sehlopha sa lithibela-mafu. Ena ke pheko ea karolo e le 'ngoe. Matlapa a tlameletsoe ho fokotsa ho tsoa ha ntho e sebetsang. Setlhare se sebetsa hantle ho loants'ang likokoana-hloko tse kotsi, tse bonts'itsoeng ke ho hanyetsa li-antibi tse ling, ka mohlala, li-macrolide. Ka khetho ea moriana, litekanyetso tsa ntho e sebetsang (400 mg) lia patoa.

Lokolla liforomo le sebopeho

Setlhare se hlahisoa ka sebopeho se tiileng. Matlapa a na le 400 mg ea ntho e sebetsang. Boemong bona, moxifloxacin ea sebetsa. Setlhare se na le likarolo tse ling, leha ho le joalo, ha li bonts'e ts'ebetso ea antibacterial, empa li sebelisetsoa ho etsa moriana oa tumellano e lakatsehang. Tsena li kenyeletsa:

starch ea poone
phospholle cellulose,
sodium methyl parahydroxybenzoate,
talcum phofo
magnesium stearate,
silica colloidal
sodium carboxymethyl starch.

Setlhare sena se fanoa ka har'a lipakete tse nang le li-pcs tse 5. lipilisi.

U ka sebelisa moxifloxacin joang ho lefu la tsoekere?

Mofumahali

Ntho e sebetsang ka sebopeho sa moriana e kenella ka potlako. Ho feta moo, motsoako ona o anngoe ka botlalo. Botebo ba ts'ebetso ena ha bo fokotsehe ha bo ntse bo ja. Melemo ea lithethefatsi e kenyelletsa bioavailability e phahameng (e fihla ho 90%). Ntho e sebetsang e tlama liprotheine ho plasma. Lenane la moxifloxacin le le sa feteng 40% ea kakaretso ea karolo e kenelletseng ts'ebetsong ena.

Peak ea ts'ebetso e fihlella lihora tse 'maloa ka mor'a tekanyetso e le' ngoe ea pilisi. Phello e matla ka ho fetisisa ea kalafo e bonoa matsatsi a 3 ka mor'a ho qala kalafo. Ntho e sebetsang e abuoa ho pholletsa le 'mele, empa ka tekanyo e kholo e bokellana matšoafong, bronchi, sinuses. Nakong ea metabolism, metsoako e sa sebetseng ea lokolloa. Moxifloxacin ha e fetohe 'me metabolites e hloekisoa ka liphi nakong ea ho ntša metsi le ho senyeha. Moriana o sebetsa hantle le kalafo ea basali le banna.

Botebo ba ts'ebetso ena ha bo fokotsehe ha bo ntse bo ja.

Matšoao a ho sebelisoa

Ka lebaka la hore ntho e sebetsang e bokellana ho isa tekanyong e kholo ea matšoafong, bronchi le sinuses, Rotomax e fana ka sephetho se setle ka ho fetisisa sa kalafo ea litho tsa kahare tsa ho hema. Leha ho le joalo, sethethefatsi se ka fihlella phello e ntle kalafong ea maemo a mang a pathological. Matšoao a sebeliso:

bronchitis e sa foleng e nang le ho mpefala,
pneumonia (sethethefatsi se laetsoe nakong ea kalafo ka ntle ho nako kapa lapeng),
mafu a litho tsa pelvic a khopisitsoeng ke likokoana-hloko tse kotsi (moriana o laetsoe haeba ho se na mathata),
tšoaetso ea letlalo le lisele tse bonolo,
sinusitis e matla
ts'oaetso e rarahaneng ea ka mpeng.

Sokolla foromo le sebopeho

Mefuta ea litekanyetso tsa moxifloxacin:

matlapa a koahetsoeng ka filimi: biconvex, ho latela moetsi: e bopehile ka sebopeho sa khase, ho tloha ho 'mala o mopinki ho isa ho o pinki, e ngotsoe ka "80" lehlakoreng le leng' me "'na" ka lehlakoreng le leng, kapa ka' mala o mosehla matlapeng kaofela ka karolo ea sefapano - mantlha e tsoa ho 'mala o mosehla o mosehla ho isa ho o mosehla (likotoana tse 5, 7 kapa 10, ngoe ka e le ngoe), ka lebokoseng la mekotla e 1, e 2 kapa e 3, likotoana tse 5, 7, 10 kapa tse 15 ka paketeng ea blister. mokotla oa karete oa likarete tsa 1-6, likotoana tse 10 e ngoe le e ngoe ka polasetiki, ka mokotleng oa karete e le 'ngoe ea 1),
Tharollo ea ho kenella: 'mala o hlakileng, o mosehla ho' mala o moputsoa o motala (50 ml e 'ngoe le e' ngoe e nang le likhalase tse se nang mebala, likhalase tse 5 ka paketeng ea karete, 250 ml ka libotlolong tsa polasetiki, mokotla oa lebokose le le leng ka hara mokotla o sa tiisitsoeng ka boqhetseke. Eena, ea lipetlele - libotlolo tse 196 ntle le mekotla ea mekotla e tiisitsoeng ka boqhetseke kapa ntle le eona ka lebokoseng la karete.

Letlapa le le leng le na le:

ntho e sebetsang: moxifloxacin hydrochloride - 436.4 mg (e lumellanang le litaba tsa moxifloxacin - 400 mg),
lisebelisoa tse ling: povidone K29 / 32 kapa K-30 (Kollidon 30), cellulose e bitsoang microcrystalline, magnesium stearate, croscarmellose sodium, ho latela moetsi, ho feta moo - lactose monohydrate, talc le silicon dioxide colloidal,
koaetso ea lifilimi (ho latela moqapi): Opadry II orange 85F23452 polyvinyl joala, titanium dioksine, macrogol, talc, letsatsi dae e putsoa ka aluminium varnish (E110), dae ea oxide dae e khubelu (E172) kapa opadray pink 02F540000 hypromellose 2910, titanium dioxide (E171), macrogol, red oxide dae red (E172), iron oxide dae yellow (E172) kapa motsoako o omileng bakeng sa ho koahela filimi ea hypromellose, iron oxide yellow (iron oxide), hyprolose (hydroxypropyl cellulose), titanium diode, talc.

Ho 1 ml ea tharollo ea infusion e na le:

ntho e sebetsang: moxifloxacin hydrochloride - 1,744 mg (ho latela moxifloxacin base - 1.6 mg),
lisebelisoa tse ling: sodium chloride, metsi bakeng sa ente, sodium hydroxide solution kapa hydrochloric acid solution, kapa (ho latela moetsi) letsoai la disodium of ethylenediaminetetraacetic acid (tharollo ea sodium hydroxide kapa hydrochloric acid - e sebelisoang ha ho hlokahala ho ntlafatsa boleng ba pH molemong).

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi, 400 mg

Letlapa le leng le na le

ntho e sebetsang - moxifloxacin hydrochloride 436.322 mg (e lekanang le moxifloxacin 400.00 mg),

baamohelang: starch ea lijo-thollo, cellulose e bitsoang microcrystalline, sodium starch glycolate, sodium methylhydroxybenzoate, colloidal silicon dioxide, talc, magnesium stearate

sebopeho sa khetla: Opadry pink 85F540146 (joala ba polyvinyl, titanium dioxide (E171), macrogol, talc, oxide e khubelu ea tšepe (E172).

Matlapa ke pinki e koahetsoeng ka filimi, e nang le kotsi ka lehlakoreng le le leng.

Melemo ea pharmacological

Mofumahali

Kamora ho tsamaisoa ka molomo, moxifloxacin e kenngoa ka potlako mme e batla e le ka botlalo. Boaoavailability e felletseng e ka ba 91%.

Kamora tekanyetso e le 'ngoe ea 400 mg ea moxifloxacin, khatello e phahameng (Cmax) maling e fihlella ka nako ea lihora tse 0.5-4 mme ke 3.1 mg / l.

Litekanyetso tse phahameng ka ho fetisisa tsa plasma tse maemong a tsitsitseng (400 mg hang hang ka letsatsi) li ne li le 3.2 le 0,6 mg / L, ka ho latellana. Boemong bo tsitsitseng, ho pepeseha ha lithethefatsi nakong ea karohano lipakeng tsa litekanyetso tsa moriana ho ka ba 30% e phahameng ho feta ka mor'a tekanyetso ea pele.

Moxifloxacin e ajoa ka potlako sebakeng sa extravascular, kamora ho nka karolo ea 400 mg ea lithethefatsi, sebaka se ka tlasa pharmacokinetic curve (AUC) ke 35 mg / h / L. Boholo ba khaso ea equilibrium (Vss) e ka ba 2 L / kg. Lithutong tsa in vitro le tsa vivo, ho tlangoa ha moxifloxacin ho liprotheine tsa plasma e ne e le 40-42%, ho sa tsotelloe ts'ebetso ea lithethefatsi. Moxifloxacin haholo e tlama le serum albin.

Litekanyetso tse latelang tsa tlhoro (geometric bolela) li ile tsa bonoa kamora ho tsamaisoa ha lethal dose le le leng la molomo la moxifloxacin, 400 mg:

Lesela

Phokotso

Karo-karolelano ea mahlahana a moriana o liseleng tsa ona ho isa mahlorisong a oona ho plasma

Mofuta oa Lithe tsa Epithelial

Sinus ea maikutlo

Phekolo ea basali.

* Tsamaiso ea methapo ea methapo e le 'ngoe ea 400 mg

Lihora tse 1 kamora ho tsamaisoa ha lithethefatsi

Likhatiso tse 2 tsa mahala

3 ho tloha lihora tse 3 ho isa ho tse 36 kamora tšebetso

4 qetellong ea infusion

Moxifloxacin e feta tlhahisong ea biotransformation ea sethala sa bobeli mme e pepesoa ka liphio le pampitšana ea mala e sa fetoheng, hape ka sebopeho sa sulfo-metso (M1) le glucuronide (M2). Li-metabolites tsena li sebetsa 'meleng oa motho feela' me ha li na mesebetsi ea ho loants'oa likokoana-hloko. Phuputso e entsoeng mabapi le tšebelisano ea metabolic pharmacokinetic le lithethefatsi tse ling e bontšitse hore moxifloxacin ha e ea biotransformed ke microsomal cytochrome P450 system. Matšoao a metabolism ea oxidative ha a eo.

Bophelo ba halofo ea lithethefatsi ho tsoa ho plasma ke lihora tse ka bang 12. Tlhahiso e akaretsang ea kamora ho nka tekanyetso ea 400 mg e tsoa ho 179 ho isa ho 246 ml / min. Tlhahiso ea semmuso, hoo e ka bang 24-53 ml / min, e etsahala ka mokhoa o sa lekanyetsoang oa lefutso ho liphio.

Ts'ebeliso e kopaneng ea ranitidine le probenecid ha e ame ho hlakisoa ha moriana.

Ho sa tsotelehe tsela ea tsamaiso, thepa e qalang moxifloxacin e batla e le 96-98% e kentsoeng ho metabolites ea mohato oa bobeli oa metabolism ntle le matšoao a metabolism ea oxidative.

Pharmacokinetics ka lihlopha tse fapaneng tsa bakuli

Ho baithaopi ba phetseng hantle ba nang le boima ba 'mele bo fokolang (mohlala, basali) le ho baithaopi ba tsofetseng, ho ile ha bonoa lintlha tse phahameng tsa plasma.

Melemo ea pharmacokinetic ea moxifloxacin ha e fapane haholo ho bakuli ba nang le bothata ba masapo (ho kenyeletsa le tumello ea creatinine> 20 ml / min / 1.73 m2). Ka ho fokotseha ha ts'ebetso ea ho ba le liphokojoe, khatello ea metabolite M2 (glucuronide) e eketseha ka lebaka la 2,5 (ka tumello ea creatinine ea 50% naheng e le 'ngoe kapa ho feta.

Tekanyetso le tsamaiso

Mokhoa o khothalelitsoeng oa litekanyetso li 400 mg hang hang ka letsatsi (250 ml ea tharollo ea infusion). Se ke oa feta tekanyetso e khothalletsoang.

Mehatong ea pele ea kalafo, tharollo ea infusion e ka sebelisoa, 'me, ho tsoela pele kalafo, haeba ho na le matšoao a tlil'o kula, moriana o ka laetsoa ka molomo matlapeng.

Pneumonia e fumanoeng ke sechaba - Nako eohle ea kalafo e khothalelitsoeng bakeng sa kalafo ea methapo (intravenous e lateloang ke kalafo ea molomo) ke matsatsi a 7-14.

Tšoaetso e rarahaneng ea letlalo le lisele tse bonolo - Nako eohle ea kalafo ea methapo ea kalafo (methapo e lateloang ke kalafo ea molomo) ke matsatsi a 7-21.

Se ke oa feta kalafo e khothalelitsoeng.

Bana le bacha

Moxifloxacin e kopantsoe le bana le lilemong tsa bocha. Ho sebetsa hantle le polokeho ea moxifloxacin ho bana le lilemong tsa bocha tse lilemo tse 18 ha e e-so thehoe.

Bakuli ba baholo

Ho fetola mofuta oa litekanyetso ho bakuli ba tsofetseng ha ho hlokahale.

Liphetoho mefuteng ea dosing merabeng ha e ea hlokahala

Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng

Ha ho na tlhahisoleseling e lekaneng mabapi le tšebeliso ho bakuli ba nang le ts'ebetso ea sebete e sa sebetseng.

Bakuli ba nang le ts'ebetso e holofetseng pleihlo la mahlo

Bakeng sa bakuli ba nang le bothata ba ho phekoloa ka lipholiso (ho kenyelletsa le tumello ea creatinine makhetlo a 5 moeli o holimo oa tloaelehileng.

Ho sebelisana le lithethefatsi

Ho sebelisana le lithethefatsi

Tlatsetso e ka bang teng ea ho lelefatsa nako ea QT e lokela ho nahanoa ha ho nka moxifloxacin le lithethefatsi tse ling tse ka holisang nako ea QTc. Ka lebaka la ts'ebeliso e kopaneng ea moxifloxacin le lithethefatsi tse amang nako ea QT, kotsi ea ho ntšetsoa pele li-ventricular arrhythmias, ho kenyelletsa polymorphic ventricular tachycardia (torsade de pointes).

Ts'ebeliso e tšoanang ea moxifloxacin le lithethefatsi tse latelang e hlakotsoe:

- Lithethefatsi tsa antiarrhythmic tsa Class I (ka mohlala, quinidine, hydroquinidine, disopyramide)

- Lithethefatsi tsa sehlopha sa antiarrhythmic tsa Class (ka mohlala, amiodarone, sotalol, dofetilide, ibutilide)

antipsychotic (mohlala, phenothiazines, pimozide, sertindole, haloperidol, sultoprid)

- baemeli ba bang ba antimicrobial (saquinavir, sparfloxacin, iv erythromycin, pentamidine, antimalarials, haholoholo halofantrine)

- antihistamine (terfenadine, astemizole, misolastine)

- ba bang (cisapride, vincamine iv, bepridil, diphemanil).

Moxifloxacin e lokela ho sebelisoa ka hloko ho bakuli ba sebelisang lithethefatsi tse theolang potasiamo (mohlala, loop le thiazide diuretics, laxatives, enemas (ka tekanyetso e phahameng), corticosteroids, amphotericin B) kapa lithethefatsi tse amanang le bradycardia ea bongaka. Nako e pakeng tsa ho nka litokisetso tse nang le li-cation tse arohaneng kapa tse marang-rang (mohlala, li-antacid tse nang le magnesium kapa aluminium, matlapa a didanosine, sucralfate le litokisetso tse nang le tšepe kapa zinki le moxifloxacin e lokela ho ba lihora tse 6.

Ha tekanyetso ea khafetsa ea moxifloxacin e ne e fuoa baithaopi ba phetseng hantle, khatello e phahameng (Cmax) ea digoxin e ile ea eketseha ka hoo e ka bang 30%, athe sebaka se tlas'a karolelano ea nako ea mahloriso (AUC) le mahloriso a fokolang (Cmin) a digoxin ha a fetoha.

Liphetho tsa boithuto bo entsoeng ho baithaopi ba nang le lefu la tsoekere le bonts'a hore ka taolo e tšoanang ea molomo ea moxifloxacin le glibenclamide, khatello ea glibenclamide maling a mali e fokotsehile ka karolo ea 21%, eo ka thello e ka lebisang tlhabisong ea mofuta o bobebe oa "hyperglycemia" ea nakoana. Leha ho le joalo, liphetoho tse hlokometsoeng tsa pharmacokinetic ha lia ka tsa lebisa ho liphetoho meralong ea pharmacodynamic (glucose ea mali, insulin).

Phetoho ho INR (karolelano e tloaelehileng ea machabeng)

Ho bakuli ba fumanang li-anticoagulants hammoho le li-antibacterial agents (haholo-holo fluoroquinolones, macrolides, tetracyclines, cotrimoxazole le li-cephalosporins tse ling), ho na le maemo a eketsehileng a ts'ebetso ea anticoagulant ea anticoagulants. Mabaka a kotsi ke ho ba teng ha lefu le tšoaetsanoang (le ts'ebetso e ts'oanang ea ho ruruha), lilemo le boemo bo akaretsang ba mokuli. Mabapi le sena, ho thata ho lekola hore na ts'oaetso kapa kalafo e baka tlolo ea INR. Hoa hlokahala ho etsa tlhahlobo ea INR khafetsa, 'me ha ho hlokahala, fetola litekanyetso tsa lithethefatsi tsa anticoagulant.

Boithuto ba kliniki bo bontšitse ho haella ha tšebelisano le tšebeliso ea nako e tšoanang ea moxifloxacin le lithethefatsi tse latelang: ranitidine, probenicide, lithibela-pelehi tsa molomo, likhalase tse nang le khalsiamo, morphine bakeng sa tšebeliso ea motsoali, theophylline, cyclosporine kapa itraconazole.

Lithuto tsa in vitro tse nang le enzymes tsa cytochrome P450 tsa motho li netefatsa liphetho tsena. Ka lebaka la liphetho tsena, ho ka fihlela qeto ea hore tšebelisano ea metabolic e kenyelletsang li-enzymes tsa cytochrome P450 ha e na monyetla.

Litšebelisano tsa lijo

Moxifloxacin ha e na tšebelisano-'meho ea bohlokoa litabeng tsa lijo, ho kenyeletsoa lihlahisoa tsa lebese.

Litharollo tse latelang ha li lumellane le tharollo ea moxifloxacin: tharollo ea sodium chloride 10% le 20%, tharollo ea sodium bicarbonate 4.2% le 8.4%.

Litaelo tse khethehileng

Melemo ea kalafo ka moxifloxacin, haholo mafu a fokolang, e lokela ho lekana le tlhaiso-leseling e fumanehang karolong ena.

Ho eketsa nako ea maqhubu a QTc le maemo a bophelo bo botle a ka amanang le ho lelefatsa nako ea QTc

Ho ile ha thehoa hore moxifloxacin e eketsa nako ea QTc ho li-electrocardiogram tsa bakuli ba bang. Tekanyo ea ho eketseha ha QT e eketseha ka khatello ea meriana e eketsehang ka plasma ea mali ka lebaka la ts'ebetso e kenang ka potlako ea masapo. Ka lebaka leo, nako ea ts'ebetso e lokela ho ba bonyane metsotso e 60 e khothalletsoang ntle le ho feta tekanyetso ea ente ea 400 mg hang ka letsatsi.

Kaha basali ba tloaetse ho lelefatsa nako ea QTc ha e bapisoa le banna, ba kanna ba ameha haholo ka lithethefatsi tse eketsang nako ea QTc. Bakuli ba tsofetseng le bona ba ka ameha haholo ka litlamorao tsa lithethefatsi tse eketsang nako ea QT.

Meriana e ka fokotsang potasiamo e lokela ho sebelisoa ka hloko ho bakuli ba fumanang moxifloxacin.

Moxifloxacin e lokela ho sebelisoa ka hloko ho bakuli ba nang le maemo a proarrhythmogenic a sa khaotseng (haholo-holo basali le bakuli ba tsofetseng), joalo ka tšohanyetso myocardial ischemia kapa nako ea nako e telele ea QT, hobane sena se ka lebisa kotsing e kholo ea ho fetoha ha li-ventricular arrhythmias (ho kenyelletsa le pirouette tachycardia) le ho tšoaroa ha pelo. Tekanyo ea ho lelefatsa nako ea QT e ka eketseha ka khatello e eketsehileng ea lithethefatsi. Ka hona, u se ke ua feta tekanyetso e khothalletsoang.

Haeba ho na le matšoao a pelo ea methapo nakong ea kalafo, o lokela ho emisa ho sebelisa moriana o etse ECG.

Hypersensitivity le allergic reaction li tlalehiloe kamora tsamaiso ea pele ea fluoroquinolones, ho kenyeletsoa moxifloxacin.

Ke ka seoelo, karabelo ea anaphylactic e ka tsoelang pele ho sokela bophelo ba lefu la anaphylactic, maemong a mang kamora ts'ebeliso ea pele ea lithethefatsi. Maemong ana, tsamaiso ea moxifloxacin e lokela ho emisoa mme mehato e hlokahalang ea kalafo (ho kenyelletsa anti-shock) e lokela ho etsoa.

Ts'ebeliso ea lithethefatsi tsa quinolone e amahanngoa le kotsi e ka ba teng ea ho ts'oaroa. Tlhokomeliso e lokela ho sebelisoa ho bakuli ba nang le ts'oaetso ea methapo ea methapo, kapa ho na le mabaka a mang a kotsi a ka 'nang a rera ho tsietsa kapa ho theola monyako oa tšenyo. Tabeng ea ho ts'oaroa, tsamaiso ea moxifloxacin e lokela ho emisoa le mehato e loketseng ea kalafo e boletsoeng.

Ho tlalehiloe maemo a sensory kapa sensorimotor polyneuropathy, e lebisang ho paresthesia, hypesthesia, dysesthesia, kapa bofokoli ho bakuli ba fumanang li-quinolones, ho kenyeletsoa le moxifloxacin. Tabeng ea matšoao a neuropathy, a kang bohloko, ho chesa, ho tsikinyeha, ho akheha kapa ho fokola, bakuli ba nkang moxifloxacin ba lokela ho bona ngaka pele ba tsoela pele kalafo.

Boitšoaro ba kelello bo ka hlaha le kamora tšebeliso ea pele ea li-quinolones, ho kenyeletsoa moxifloxacin. Maemong a sa tloaelehang, khatello ea maikutlo kapa maikutlo a kelello a ile a tsoela pele ho ipolaea le boitšoaro ka mokhoa oa ho intša kotsi, joalo ka liteko tsa ho ipolaea. Haeba mokuli a e-ba le karabelo e joalo, moxifloxacin e lokela ho khaotsa mme mehato e loketseng e nkuoe. Ho khothalletsoa ho ba hlokolosi haholo ha o fana ka moxifloxacin ho bakuli ba psychotic kapa bakuli ba nang le nalane ea bokuli ba kelello.

Ka tšebeliso ea moxifloxacin, ho tlalehiloe linyeoe tsa nts'etsopele ea lefu la hepatitis e tlatselletsang, le ka 'nang la baka ho se atlehe ha sebete ha sebete, ho kenyeletsoa le phello e bolaeang. Bakuli ba lokela ho ea ngakeng hang-hang pele ba tsoela pele kalafo haeba ho e-na le matšoao le lefu la hepatitis le tlatselletsang, le kang asthenia e potlakileng e amanang le jaundice, moroto o lefifi, tšekamelo ea ho tsoa mali, kapa hepatic encephalopathy. Ha ho na le matšoao a ho hlobaela ha sebete, ho hlokahala ho etsa tlhahlobo ea ts'ebetso ea sebete.

Ho tlalehoa ha ho na le liketsahalo tse ngata tse amanang le letlalo le fanang ka maikutlo a mangata. Haeba likarabelo tse tsoang letlalong le / kapa lipelong tsa mucous li hlaha, o lokela ho etela ngaka hang-hang pele o tsoela pele kalafo.

Letšollo le amanang le li-antibiotic (AAD) le colitis e amanang le lithibela-mafu (AAK), ho kenyeletsa le pseudomembranous colitis le Clostridium Hardile-ketsahalo e amanang le lets'ollo, ho tlalehiloe mabapi le ts'ebeliso ea lithethefatsi tsa antibacterial tse pharalletseng, ho kenyeletsoa moxifloxacin, mme li ka fapana ka boholo ho tloha lets'ollo le bonolo ho isa ho lefu le bolaeang. Ka hona, ho bohlokoa ho boloka ts'oaetso ena ho bakuli ba nang le lets'ollo le matla nakong ea kapa ka mor'a ho nka moxifloxacin. Haeba AAAD kapa AAK e belaelloa kapa e netefalitsoe, ho hlokahala hore u khaotse ho sebelisa sethethefatsi se loantšang tšoaetso, ho kenyeletsa moxifloxacin, le ho fana ka mehato e loketseng ea kalafo. Ntle le moo, mehato e loketseng ea taolo ea ts'oaetso e lokela ho nkuoa ho fokotsa kotsi ea tšoaetso. Bakuli ba nang le lets'ollo le matla ba kopantsoe le lithethefatsi tse thibelang matla a ka mpeng.

Moxifloxacin e lokela ho sebelisoa ka hloko ho bakuli ba nang le myasthenia gravis, kaha lithethefatsi li ka mpefatsa matšoao a lefu lena.

Ho ruruha le ho phatloha ha metso (haholo-holo Achilles tendon), ka linako tse ling tse peli, li ka hlaha nakong ea kalafo ka li-quinolones, ho kenyeletsoa moxifloxacin, le kamora lihora tse 48 kamora ho qala kalafo, mme linyeoe li tlalehiloe kamora likhoeli tse 'maloa ka mor'a ho khaotsa kalafo. Kotsi ea ho phatloha ha tendonitis le tendon e eketseha ho bakuli ba tsofetseng le ho bakuli ba tšoaroang ke corticosteroids ka nako e le 'ngoe. Ponong ea pele ea bohloko kapa ho ruruha, bakuli ba lokela ho emisa ho nka moxifloxacin, ba imolle le maoto le matsoho a amehang mme hang-hang ba ee ngakeng ho fumana kalafo e loketseng (e.g. immobilization).

Ha u sebelisa li-quinolones, mokhoa oa photosensitivity reaction o ile oa bonoa. Leha ho le joalo, lithuto li bontšitse hore moxifloxacin e na le kotsi e tlase ea photosensitivity. Leha ho le joalo, bakuli ba lokela ho qoba ho pepesehela mahlaseli a UV kapa khanya ea letsatsi ka ho toba nakong ea kalafo le moxifloxacin.

Moxifloxacin ha e khothalletsoe kalafo ea ts'oaetso e bakoang ke methapo ea methapo e thibelang methapo ea methapo ea Staphylococcus aureus (MRSA). Haeba ho na le ts'oaetso e belaelloang kapa e netefalitsoeng e bakoang ke staphylococcus e thibelang methicillin, hoa hlokahala ho fana ka kalafo ka moriana o nepahetseng oa antibacterial.

Bokhoni ba moxifloxacin ba ho thibela kholo ea mycobacteria bo ka ama sephetho sa liteko Mycobacterium spp., e lebisang liphellong tse mpe tse fosahetseng ha ho hlahlojoa mehlala ea bakuli ba tšoaroang ke moxifloxacin nakong ena.

Joalo ka le fluoroquinolones tse ling, ts'ebeliso ea moxifloxacin e bontšitse phetoho ea khatello ea tsoekere ea mali, ho kenyelletsa hypo- le hyperglycemia. Nakong ea phekolo ea moxifloxacin, dysglycemia e hlahile haholo ho bakuli ba tsofetseng ba nang le lefu la tsoekere ba fumanang kalafo e kopanetsoeng ka litlhare tsa hypoglycemic (mohlala, lithethefatsi tsa sulfonylurea) kapa insulin. Ha u phekola bakuli ba nang le lefu la tsoekere, ho khothalletsoa ho lekola ka hloko boemo ba tsoekere ea mali.

Moxifloxacin e lokela ho sebelisoa ka hloko ho bakuli ba tsofetseng ba nang le lefu la liphio haeba ba sa khone ho boloka tšebeliso e lekaneng ea mokelikeli, kaha ho felloa ke metsi ho ka eketsa kotsi ea ho se sebetse ha liphio.

Ka nts'etsopele ea bofokoli ba pono kapa matšoao a mang a mahlo, o lokela ho etela ngaka ea mahlo kapele.

Bakuli ba nang le nalane ea lelapa kapa khaello ea 'nete ea glucose-6-phosphate dehydrogenase ba tloaetse ho fetoha ha hemolytic ha ba phekoloa ka li-quinolones. Moxifloxacin e lokela ho fanoa ka hloko ho bakuli bana.

Tharollo ea tlhahiso ea moxifloxacin ke ea tsamaiso ea methapo feela. Boithuto ba pelehi bo bonts'itse ho ba teng hoa periarterial ho ruruha ha lisele ka mora ts'ebetso ea intraarterial ea moxifloxacin, ka hona, mokhoa ona oa tsamaiso o lokela ho qojoa.

Bokhachane le pelehi

Tšireletseho ea ho nka moxifloxacin nakong ea kemolo ho basali ha e so hlahlojoe. Lithuto tsa liphoofolo li bontšitse chefo ea ho beleha. Kotsi e ka bang teng ho batho ha e tsejoe. Ka lebaka la tlhaiso-leseling mabapi le tšenyo ea mokokotlo oa manonyeletso a maholo ke fluoroquinolones ho liphoofolo tse tlang pele ho nako le likotsi tse fetohang tse kopaneng tse hlalositsoeng ho bana ba tšoaroang ke fluoroquinolones, moxifloxacin ha ea lokela ho laeloa basali ba baimana.

Lintlha tse mabapi le tšebeliso ea lithethefatsi ho basali nakong ea lebactation ha li fumanehe. Liphuputso tse entsoeng esale pele li fumane hore lihlahisoa tse nyane tsa moxifloxacin li tšeloa lebese la matsoele. Ts'ebeliso ea moxifloxacin nakong ea kanyeso e hanoa.

Lintlha tsa phello ea lithethefatsi ho bokhoni ba ho khanna makoloi le mekhoa e ka bang kotsi.

Lithethefatsi li ka sitisa bokhoni ba bakuli ba ho khanna makoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang tlhokomelo e eketsehileng le karabelo e potlakileng ea psychomotor ka lebaka la ts'ebetso ea tsamaiso ea methapo ea kutlo le ho senyeha ha mahlo.

Bongata

Tlhahisoleseling ea overdose e fokolang ea fumaneha.

Maemong a bosholu, motho o lokela ho tataisoa ke setšoantšo sa bongaka le ho etsa lipontšo tsa kalafo ea matšoao a ECG. Ts'ebeliso ea khabone e sebelisitsoeng bakeng sa kalafo ea overdose ka tsamaiso ea molomo kapa infusion ea 400 mg ea moxifloxacin e kanna ea nepahala ho thibela keketseho e kholo ea tlhahiso ea "moxifloxacin" e fetang 80% kapa 20%, ka ho latellana.

Moetsi

Scan Biotech Limited, India

Lebitso le naha ea setifikeiti sa ngoliso

Routec Limited, UK

Aterese ea mokhatlo e amohelang likopo tse tsoang ho bareki ka boleng ba lihlahisoa (thepa) le boikarabello bakeng sa ho beha leihlo ka mor'a tšebeliso ea ts'ireletso ea lithethefatsi tikolohong ea Rephabliki ea Kazakhstan

St. Dosmukhametova, 89, setsi sa khoebo "Caspian", ofisi 238, Almaty, Rephabliki ea Kazakhstan.

Litlhahlobo mabapi le lithethefatsi

Hoo e batlang e le litlhahlobo tsohle tsa mokuli, Moxifloxacin e sebetsa hantle haholo khahlanong le moemeli oa lefu lena le ntlafatso e potlakileng ea boemo ba bophelo bo botle.

Leha ho le joalo, bahlahlobisisi ba bangata ba tletleba ka litla-morao tse ling kamora ho sebelisa moriana ona. Har'a tsona, tse boletsoeng khafetsa ke: ho nyekeloa ke pelo, lets'ollo, bohloko bo nyane ba ka mpeng, ho tsekela, ho opeloa habohloko sefubeng, ho opeloa ke hlooho, tachycardia, ho hloka boroko, ho tšoenyeha le khatello ea maikutlo.

Bakuli ba bang ba bolela hore ho felisoa ha litla-morao ho tsamaisoa ka ho nka matlapa a Moxifloxacin nakong ea lijo le ho noa metsi a mangata a nang le liminerale ka mor'a ho sebelisa moriana.

Litlhahlobo tse 'maloa li hlalositse hore ho sebelisa lithethefatsi ho bakile pherekano ho basali, e neng e felisoa habonolo ka ho nka Difluzole (kapa sethethefatsi se tšoanang).

Litlhahlobo tsa marotholi a mahlo a Vigamox bakeng sa karolo e kholo li ntle. Ba ne ba mamelletsoe hantle ke bakuli mme ba sa bake litlamorao. Bangoli ba litlhahlobo ba hlokomela ho felisoa ha bobebe ba mahlo le matšoao a lefu le ka tlase.

Tlhahlobo ea hypersensitivity ho marotholi a Vigamox a fumaneha seoelo. Maemong ana, bakuli ba hlokometse ponahalo ea ho hlohlona le ho ba mafubelu mahlong. Kamora ho tlohela moriana, matšoao ana a ile a nyamela kapele.

Boholo ba bakuli ba arabela theko ea Moxifloxacin le li-analogues tsa eona e le "holimo."

Theko ea lithethefatsi naheng ea Russia le Ukraine

Theko ea Moxifloxacin e ipapisitse le mofuta oa tokollo, k'hemiste le toropo e rekisang lithethefatsi. Pele u e reka, u hloka ho hlakisa theko ea eona ka har'a makareche a 'maloa ebe u buisana le ngaka ea hau ka tlhahiso ea eona e ka bang teng ka analogue, kaha ke setlhare sena se ke keng sa fumanoa se rekisoa kamehla. Khafetsa marang-rang a rekisang litlama a rekisa li-analogues (li-synonyms) tsa Moxifloxacin ho feta sena lithethefatsi ka botsona.

Theko e tloaelehileng ea li-analogues (li-synonyms) tsa Moxifloxacin libakeng tsa polokelo ea meriana Russia le Ukraine:

Tharollo ea Avelox bakeng sa infravenous infusion 400 mg / 250 ml 1 botlolo - li-ruble 1137 - 1345, li-600-1066 hlemonias,
Moxifloxacin-Farmex tharollo ea infravenous infusion 400 mg / 250 ml 1 botlolo - 420-440 hryvnia,
Tharollo ea Maxicin bakeng sa infravenous infusion 400 mg / 250 ml 1 botlolo - 266-285 hryvnia,
Letlapa la Avelox 400 mg, likotoana tse 5 ka pakete - li-ruble tse 729-861, li-ruble tse 280-443,
Leihlo la Vigamox le theoha 0.5% 5 ml - li-ruble tse 205-160, li-hmmnias tse 69-120.

Mofumahali

Moxifloxacin ke lithethefatsi tse thibelang likokoana-hloko tsa sehlopha sa fluoroquinolone, se nang le ts'oaetso ea baktheria, mochine oa sona o bakoang ke thibelo ea "bacteric enzymes topoisomerase II" (DNA gyrase) le topoisomerase IV, tse hlokahalang bakeng sa phetiso, phetiso le tokiso ea lefu le tlisoang ke lefutso la morao-rao le tsamaisang lefu la methapo ea lefutso ea lefutso. lisele.

Tekanyo e nyane ea bactericidal ea ntho hangata e lumellana le botebo ba eona bo fokolang ba inhibitory (MIC). Ts'ebetso ea antibacterial ha e ferekanngoe ke mekhoa e isang ho hanyetsanang le li-macrolides, aminoglycosides, cephalosporins, penicillin le tetracyclines. Ha ho khahlano le sefapano se ileng sa bonoa pakeng tsa lihlopha tsena tsa lithibela-mafu le moxifloxacin, 'me ha ho lintlha tse amanang le ho hanyetsa ka plasmid. Ho hanyetsa ntho e sebetsang ho hlaha butle butle ka liphetoho tse ngata. Khahlano le nalane ea litla-morao tsa lithethefatsi ho likokoana-hloko tse haufi le MIC, ke keketseho e nyane feela ea lets'oao lena.Ho hanyetsa sefapano sa quinolones ho fumanoe, leha ho le joalo, likokoana-hloko tse ling tsa gram-positive le anaerobic tse bontšang ho hanyetsa likarolo tse ling tsa quinolones li bonts'a kutloisiso ea moxifloxacin.

Lithuto tsa in vitro li bonts'itse ts'ebetso khahlano le likokoana-hloko tse ngata tsa anaerobes, gram-negative le gram-virus, baktheria e hanyetsanang le asiti, ho kenyeletsoa joalo ka Legionella spp. Chlamydia spp, Mycoplasma spp. ketso ea lithibela-mafu tsa P-lactam le macrolide.

Lithutong tse peli tse entsoeng ho baithaopi, kamora ho tsamaisoa ha molomo oa ntho e sebetsang, ho ile ha bonoa liphetoho tse latelang ka har'a microflora ea mala: ho fokotseha ha maemo a Bacteroides vulgatus, Bacillus spp. Escherichia coli, Klebsiella spp. Enterococcus spp. . le Bifidobacterium spp. Palo ea likokoana-hloko tsena e khutlile e tloaelehileng nakong ea libeke tse peli. Chefo ea Clostridium Hardile ha ea ka ea fumanoa.

Ka tlase ho na le likokoana-hloko tse kenyellelitsoeng har'a karolo ea tšebetso ea antibacterial ea moxifloxacin.

Mefuta ea likokoana-hloko tse latelang e amehile ka ts'ebetso ea moriana:

gram-negative aerobes: Haemophilus influenzae le Moraxella catarrhalis (ho kenyelletsa le lits'oants'o tse hlophisang eseng ho kopanya beta-lactamases) *, Haemophilus parainfluenzae *, Proteus vulgaris, Acinetobacter baumannii, Bordetella pertussis,
Li-aerobes tse nang le ts'oaetso ea Gram: Gardnerella vaginalis, Streptococcus pneumoniae *, ho kenyelletsa mathata a hanyetsang lithibela-mafu tse ngata le mathata a bonts'ang ho hanyetsa penicillin, le mathata a bonts'ang lithibela-mafu tse peli kapa ho feta, tse kang penicillin (MIC ho feta 2 μg / ml ), tetracyclines, cephalosporins II isa molokong o mong (mohlala, cefuroxime), trimethoprim-sulfamethoxazole, macrolides, Streptococcus milleri (Streptococcus constellatus *, Streptococcus anginosus *, Streptococcus intermedius *), Streptococcus pyogenes (sehlopha A) *, Streptococcus vir>

Likokoana-hloko tsa likokoana-hloko tse latelang li amehile ka ho hlaka ketso ea moxifloxacin:

li-aerobes tse ntle le gram: Enterobacter spp. (Enterobacter sakazakii, Enterobacter intermedius, Enterobacter aerogene), Citrobacter freundii **, Klebsiella pneumoniae *, Escherichia coli *, Klebsiella oxytoca, Pantoea agglomerans, Enterobacter cloacae *, Stenotrophomonas maltophiliaomulululululululululululululululululululululululululululululululululululululululululululululululululululululululululululululususmulimmulimmulimmulammulam. Providencia spp. (Providencia stuartii, Providencia rettgeri), Neisseria gonorrhoeae *,
gros-aerobes e ntle: Enterococcus faecium *, Enterococcus avium *, Enterococcus faecalis (ke mefuta feela e amehang ka boroko le vancomycin) *,
anaerobes: Clostridium spp. *, Peptostreptococcus spp. * Bacteroides spp. (Bacteroides vulgaris *, Bacteroides fragilis *, Bacteroides thetaiotaomicron *, Bacteroides distasonis *, Bacteroides sareis *, Bacteroides ovatus *).

Likokoana-hloko tse latelang li loantšana le sethethefatsi: coagulase-negative Staphylococcus spp. (methicillin e thibelang mafu a Staphylococcus cohnii, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus simureans)

* Boikutlo ba likokoana-hloko ho moxifloxacin bo tiisoa ke data ea kliniki.

** Ts'ebeliso ha e khothaletsoe bakeng sa kalafo ea ts'oaetso e bakoang ke methapo ea methapo ea methapo ea methapo ea methapo ea kutlo e bitsoang "aureus" (MRSA). Haeba ts'oaetso ea MRSA e netefalitsoe kapa e belaelloa, ho hlokahala meriana e meng ea antibacterial bakeng sa kalafo.

Tsamaiso ea khanyetso ea lithethefatsi tse fumanehang bakeng sa mefuta e meng e kanna ea fapana ha nako e ntse e fapana mme e fapana ka sebaka Ha ho hlahlojoa kutloisiso ea khatello ea methapo, ho khothaletsoa ho ba le data ea hanyetsano ea lehae, e bohlokoa haholo kalafong ea ts'oaetso e matla.

Bokhachane le pelehi

Nakong ea kemolo, kalafo ea moxifloxacin e hanyetsoa ka lebaka la khaello ea tlhaiso-leseling ea kliniki e netefatsang polokeho ea eona nakong ena. Ho bana ba nkang li-quinolones, ho ile ha tlalehoa linyeoe tsa tšenyo e kopanetsoeng ea morao-rao, empa ho ne ho se na litlaleho tsa ho hlaha hoa Psychology ena ka popelong ha e sebelisoa ke 'm'a bona nakong ea kemolo. Lithutong tsa liphoofolo, ho ba le chefo ea botala ea meriana ho fumanoe, empa kotsi e ka bang teng ho batho ha e so tsebisoe.

Kaha palo e nyane ea moxifloxacin e fetela lebese la matsoele, mme ha ho na datha mabapi le ts'ebeliso ea basali ba anyang matsoele, ts'ebeliso ea eona e hanyetsoa nakong ea ho beleha.

Ka ho se sebetse hantle ha sebete

Moxifloxacin e patiloe hore e sebelisoe maemong a ho senyeha ha sebete sa sehlopha sa C ho latela sehlopha sa bana-Pugh, hammoho le khatello ea transaminase e fetang makhetlo a mahlano a VGN, ka lebaka la tlhahlobo ea tlhahlobo ea tlhahlobo ea kliniki. Boteng ba cirrhosis, ho kopantsoe le ts'ebeliso ea lithethefatsi kapa tlhokomelo e khethehileng e lokela ho nkuoa (ho latela moetsi).

Ho bakuli ba nang le mathata a ts'ebetso ea sebete sa sehlopha sa A le B sethaleng sa bana, ha ho na lebaka la ho fetola mofuta oa mofuta oa moxifloxacin.

Ho sebelisana le lithethefatsi

tricyclic antidepressants, hydroquinidine, quinidine, disopyramide (class IA antiarrhythmics), ibutilide, dofetilide, sotalol, amiodarone (sehlopha sa boraro antiarrhythmics), halofantrine (antimalarials), pentamidine, erythromycin (e nang le iv) ), sultopride, haloperidol, sertindole, pimozide, phenothiazine (antipsychotic), misolastine, astemizole, terfenadine (antihistamines), diphemanil, bepridil, vincamine (ka iv tsamaiso), cisapride le lithethefatsi tse ling tse amang elongation le Tervala QT: ho sebelisa ha bona ho kopantswe le moxifloxacin e contraindicated ka lebaka la ho aggravation ba kotsing ea ho arrhythmia ventricular (ho akarelletsa mofuta ventricular tachycardia torsade de Khao pointes ..),
Litokisetso tse nang le iron, zinc, magnesium le aluminium, antacids, litlhare tse thibelang vaerase (didanosine), sucralfate: ho fokotseha ho hoholo ha mohopolo oa moxifloxacin hoa khoneha ka lebaka la ho thehoa ha li-chelate complexes tse nang le li-cation tse ngata tse kenyellelitsoeng sebopeng sa tsona, nako ea ho nka lipilisi tsena le moxifloxacin. e be bonyane lihora tse 4
khabone e sebetsitsoeng: ka lebaka la thibelo ea ho monya motsoako o thibelang likokoana-hloko, bioavailability ea eona e fokotseha ka ho feta 80% (ha e nkuoa ka molomo 400 mg),
digoxin: ha ho na phetoho ea bohlokoa maemong a pharmacokinetic,
warfarin: ha ho na phetoho ea nako ea prothrombin le litekanyetso tse ling tsa coagulation ea mali, leha ho le joalo, ho ka etsahala ho eketsa ts'ebetso ea lithethefatsi tsa anticoagulant, lintlha tsa kotsi li kenyelletsa ho ba teng ha mafu a tšoaetsanoang, boemo bo akaretsang le lilemo tsa mokuli, ho hlokahala hore ho hlahlojoe INR mme, haeba ho hlokahala, fetola litekanyetso tsa anticoagulants e sa tobang,
cyclosporine, calcium supplements, atenolol, theophylline, ranitidine, lithibela-pelehi tsa molomo, itraconazole, glibenclamide, morphine, digoxin, probenecid - ha ho na tšebelisano ea bohlokoa ea lithethefatsi tsena tsa moxifloxacin e fumanoeng (liphetoho tsa tekanyetso ha li hloke),
sodium bicarbonate tharollo ea 4,2 le 8,4%, tharollo ea sodium chloride ea 10 le 20% - litharollo tsena ha li lumellane le tharollo ea inflex ea moxifloxacin (ka nako e ts'oanang e thibetsoe ho kena).

Analogs tsa moxifloxacin ke Vigamoks, Alvelon-karaoke mf Megafloks, Avelox, Moksigram, Maksifloks, Akvamoks, Moksistar, Moksiflo, Moksispenser, Moksimak, Moxifloxacin Sandoz, Moxifloxacin CHP Moxifloxacin Alvogen, Moflaksiya, Moxifloxacin STADA, Moxifloxacin Canon Moxifloxacin-Verein , Plevilox, Rotomox, Moxifur, Moxifloxacin-TL, Ultramox, Simoflox, Heinemox.