Diabetesalong - litaelo tsa tšebeliso

Litaelo tsa ho sebelisoa:

Litheko tsa litlhare tsa marang-rang:

Diabetesalong ke sulfonylurea ea moloko oa bobeli, e leng sethethefatsi se bitsoang hypoglycemic bakeng sa tsamaiso ea molomo.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - matlapa a lokolloang (60 mg) le matlapa a lokollotsoeng (30 mg): sephara-cylindrical, hoo e batlang e le tšoeu kapa e tšoeu, e nang le bevel, marang-rang e lumelletsoe, matlapa a 60 mg a sephara, a nang le mola o arohanang (ka har'a contour ho paka ka seleng: 60 mg, e 'ngoe le e' ngoe - 10 likhomphutha., ka mekotleng ea 1, 2, 3 kapa 6, li-pcs tse 20, ka mekotleng ea karete ea 1, 3, 5 kapa 6, 30 mg - 10 likhomphutha. ka lebokoseng la likarete tse 3 kapa tse 6).

Letlapa le le leng le na le:

ntho e sebetsang: gliclazide - 60 mg kapa 30 mg,
likarolo tse thusang: aerosil (colloidal silicon dioxide), calcium stearate, matlapa a 80 (lactose monohydrate), hypromellose (Metocel K-100 LV CR Premium), talc.

Ntle le moo, matlapeng a lokolloang nako e telele sebopeho sa hypromellose - Metolosa 90 SH-100SH.

Matšoao a ho sebelisoa

Ts'ebeliso ea Diabetesalong e bontšoa kalafo ea lefu la tsoekere la mofuta oa 2 ha ho na phello e lekaneng ea kalafo ea ho ja, ho ikoetlisa 'meleng le ho theola boima ba' mele.

Ntle le moo, ho fanoa ka matlapa a nts'etsopele a thibelo ea mathata a lefu la tsoekere ho fokotsa kotsi ea ho tšoaroa ke lefu la lefu la tsoekere, lefu la ho ferekanya lefu la myocardial, stroke ka taolo e matla ea lefu la tsoekere.

Contraindication

mofuta oa 1 lefu la tsoekere
lefu la tsoekere ketoacidosis, lefu la tsoekere, lefu la tsoekere,
phekolo e kopanetsoeng le miconazole,
ho hloleha ho matla ha hepatic le / kapa ho ba le methapo,
nako ea kemaro
sefuba
lilemo tse 18
khaello ea lactase, tsoekere e nang le glucose-galactose malabsorption, ho se mamelle lactose,
tšebeliso e tšoanang ea phenylbutazone kapa danazole,
hypersensitivity ho sulfonamides, tse ling tse tsoang ho sulfonylurea, likarolo tsa moriana.

Ka hlokolosi, ho hlokahala ho fana ka taelo ea lefu la tsoekere ho bakuli ba nang le phepo e sa tloaelehang le / kapa ba sa e lekanye, khaello ea glucose-6-phosphate dehydrogenase, mafu a matla a tsamaiso ea methapo ea pelo (ho kenyelletsa lefu la pelo, atherosulinosis), hypopituitarism, hypothyroidism, adrenal insufficiency kapa / kapa ho hloleha ha sebete, ts'ebeliso ea nako e telele ea glucocorticosteroids, ea nang le tahi ea joala, botsofaling.

Tekanyetso le tsamaiso

Matlapa a nooa ka molomo, a metsa hohle, haholo-holo nakong ea lijo tsa hoseng, nako e le 1 ka letsatsi.

Tekanyo ea lithethefatsi e lokela ho khethoa ka khetho, ho latela khatello ea motho ka mong ea tsoekere le glycosylated hemoglobin maling.

Letlapa le le leng la 60 mg le lekana le phello ea kalafo ea matlapa a 2 a 30 mg. Ho arohana ha kotsi matlapeng a 60 mg ho lumella, haeba ho hlokahala, ho e arola likarolo tse peli. Haeba, ka lebaka la karohano, halofo ea letlapa le putlame, ha ea lokela ho nkuoa.

Tekanyetso e khothalelitsoeng ea letsatsi le letsatsi: tekanyetso ea pele (ho kenyeletsa bakuli ba fetang 65) ke 30 mg, ka karabelo e lekaneng e sebelisoa e le lethal dose. Ha ho na taolo e lekaneng ea glycemic, tekanyetso ea letsatsi le letsatsi e lokela ho ba ka tatellano (eseng nako e le 'ngoe ho libeke tse 4) e nyolohetse ho 60, 90 kapa 120 mg. Haeba phokotso ea khatello ea tsoekere maling e sa hlahe kamora libeke tse 2 ho nka litafole, joale lethalinyana le eketsoa ka nako ea libeke tse peli.

Se ke oa nka tekanyetso e phahameng ka mor'a ho tlola tekanyetso e le 'ngoe kapa tse' maloa.

Sekhahla se phahameng sa letsatsi ke 120 mg.

Ha o fetoha ho tsoa ho moemeli e mong oa hypoglycemic ea molomo, tekanyetso ea eona le halofo ea bophelo e lokela ho tsotelloa.

Haeba sehlahisoa sa pele se tsoang ho sulfonylurea derivatives se ne se e-na le nako e telele ea bophelo, ho khothalletsoa ho nka khefu ho nka litekanyetso tse 'maloa pele u nka moriana. Sena se tla qoba hypoglycemia khahlano le semelo sa tlatsetso ea mahlahana a mabeli a hypoglycemic. Kamora libeke tse 'maloa, ho hlahlojoa ka hloko maemo a tsoekere ea mali hoa hlokahala.

Tekanyetso ea pele ea lefu la tsoekere e lokela ho lula e le 30 mg.

Matlapa a bontšoa hammoho le li-agents tsa hypoglycemic joalo ka biguanides, alpha glucosidase inhibitors kapa insulin.

Bakuli ba nang le phofo e sa lekaneng ea ho leka-lekana ho teba ho tekano ba beoa tekanyetso e tloaelehileng ea moriana, empa kalafo e lokela ho etsoa ka tlasa tlhokomelo e haufi ea bongaka.

Hobane bakuli ba nang le phepo e sa lekaneng kapa e sa leka-lekanang, mathata a endocrine a tebileng kapa a sa fuoeng hantle, matšoao a matla a amanang le lefu la pelo (lefu la pelo la mokokotlo, atherosclerosis e tloaelehileng, carotid arteriossteosis) kapa kamora ho hlakola kalafo ea nako e telele le / kapa kalafo. tekanyetso e phahameng, li-glucocorticosteroids li kotsing ea ho ba le hypoglycemia, ha ea lokela ho fuoa 30 mg ea lithethefatsi ka letsatsi.

Ho thibela mathata a lefu la tsoekere nakong ea tšebeliso ea lithethefatsi, bakuli ba lokela ho latela lijo tse khothalelitsoeng ke ngaka, ho ikoetlisa khafetsa, 'me haeba boemo bo mpefala, etela ngaka hang-hang.

Litlamorao

Nts'etsopele ea hypoglycemia: matšoao - tlala e matla, ho fufuleloa ho eketsehileng, bofokoli, letlalo le loanang, ho opeloa ke hlooho, ho nyekeloa ke pelo, ho hlatsa, ho ferekana ho matla, ho teneha, ho hloka boroko, ho ferekana, ho lieha ho arabela, ho fokotsa khatello ea maikutlo, khatello ea maikutlo, pono e sa sebetseng le puo, pherekano , aphasia, ho thothomela, ho ikutloa eka ha ho na thuso, paresis, ho sitoa ho itaola, ho akheha kelellong, ho tsekela, ho otsela, bradycardia, delirium, ho phefumoloha ho sa tebang, ho tsitsipana, matšoenyeho, tachycardia, ho eketseha ha sesole khatello ea kelello, arrhythmia, angina pectoris, palpitations, ho lahleheloa ke letsoalo, ho akheha, lefu,
Ho tsoa mokhatlong oa ka mpeng: ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, lets'ollo, ho sokela,
karabelo ea letlalo: ho hlohlona, lekhopho la letlalo, uritisaria, erythema, edincke's edema, leqhetsoana la maculopapular, lefu le kotsi la hlahala ea lefu la setho,
ho tsoa ho litho tsa hematopoietic le tsamaiso ea methapo ea methapo: mathata a nakoana a hematological - leukopenia, anemia, thrombocytopenia, granulocytopenia,
ho tsoa ts'ebetsong ea hepatobiliary: ts'ebetso e eketsehileng ea alkaline phosphatase, aspartate aminotransferase (ACT), alanine aminotransferase (ALT), maemong a sa tloaelehang - hepatitis, cholestatic jaundice,
ho tsoa liphoofolong tsa maqhubu a maikutlo: ho ferekana habonolo hoa pono (hangata khafetsa qalong ea kalafo),
tse ling: litla-morao tse tloaelehileng (litla-morao tse tloaelehileng tsa sulfonylurea derivatives) - ho hloleha ka matla ha sebete, agranulocytosis, erythrocytopenia, hemolytic anemia, alculgic vasculitis, pancytopenia, hyponatremia.

Litaelo tse khethehileng

Khahlano le semelo sa tšebeliso ea lefu la tsoekere, hammoho le tse ling tse tlisoang ke sulfonylurea, ho na le kotsi ea hypoglycemia. Ho emisa matšoao a eona, mokuli o lokela ho nka hang-hang sehlahisoa leha e le sefe se nang le lik'habohaedreite (tsoekere e ka ba), li-badala tsa tsoekere boemong bona ha li sebetse.

Tabeng ea mefuta e matla le ea nako e telele ea hypoglycemia, mokuli o hloka ho kena sepetlele le ho kenella kahare ho tharollo ea dextrose ka matsatsi a 'maloa.

Ha a fana ka litlhare, mokuli le litho tsa lelapa la hae ba lokela ho tsebisoa ka botlalo ka tlhokeho ea ho latela melao e matla ea lijo kamehla, ho kenyelletsa le lijo tsa hoseng, likotsi le matšoao a hypoglycemia, hammoho le maemo a amanang le kholo ea eona. Kaha phepo e sa lekanyetsoang, e sa lekaneng kapa e nang le lik'habohaedreite e eketsa kotsi ea ho ba le hypoglycemia, ho bohlokoa haholo ho latela litlhahiso tsohle tsa ngaka.

Ntle le lijo tse nang le khalori e tlase, hangata hypoglycemia e bakoa ke ho ikoetlisa ka nako e telele kapa ho ikoetlisa ka matla, ho noa joala kapa ho sebelisa lithethefatsi tse 'maloa tsa hypoglycemic ka nako e le' ngoe.

Re lokela ho hopola hore ho na le monyetla oa ho oela hape ho hypoglycemia kamora katleho ea tokollo ea pele e atlehileng.

Lintho tse latelang li baka kotsi e kholo ea hypoglycemia:

ho tsilatsila kapa ho se khonehe ha mokuli (hangata maqheku) ho laola boemo ba hae le ho latela litaelo tsa ngaka ka tieo,
ho se latele mmuso le lijo,
tlolo ea tekano lipakeng tsa tšebeliso ea lik'habohaedreite le ho ikoetlisa,
tšebeliso e tšoanang ea lithethefatsi tse ntlafatsang phello ea hypoglycemic ea lithethefatsi,
ho hloleha ho matla ha sebete
ho hloleha ha rems
Psychology ea tšoelesa ea tšoelesa ea qoqotho
overdose ea Diabetesalong.

Liphetoho mokhoeng oa pharmacokinetic le / kapa ea pharmacodynamic ho bakuli ba nang le renal le hepatic insufficiency li na le phello e mpe ho teba ha hypoglycemia nakong ea kholo ea eona.

Ho bohlokoa ho nka sethethefatsi sena ka mokhoa oa ho itlhahloba tshekong ea tsoekere ea mali.

Ka khaello ea glucose-6-phosphate dehydrogenase, moriana o ka kenya letsoho kholisong ea anemia ea hemolytic, ka hona ho khothalletsoa ho nahana ka monyetla oa ho beha moemeli oa hypoglycemic oa sehlopha se seng.

Tabeng ea bokuli bo tšoaetsanoang kapa ho buuoa ho hoholo, ho lokela ho nahanoa ka ho felisoa ha kalafo ea lithethefatsi le ho khethoa ha kalafo ea insulin.

Lebaka la tloaelo ea ho fokotseha hoa phello ea hypoglycemic ea Diabetesalong kamora tšebeliso ea nako e telele e kanna ea fokotseha ka karabelo ea kalafo le kholo ea lefu lena. Ha a hlahloba ho hanyetsa lithethefatsi tsa bobeli, ngaka e lokela ho lekola ka hloko tekanyetso ea tekanyetso e nkuoeng ke mokuli le ho etsa bonnete ba hore e latela lijo tse boletsoeng.

Ho nwa moriana nakong ea lijo tsa hoseng ho fokotsa kotsi ea litla-morao.

Ka matla a maholo a sebete le / kapa ho se sebetse hantle, mokuli o khothalletsoa ho sebelisa insulin.

Ha a rera ho ima kapa ho ima nakong eo a noang moriana, ho khothalletsoa mosali hore a fetole kalafo ea insulin.

Ka lebaka la kotsi ea hypoglycemia, bakuli ba eletsoa hore ba be hlokolosi ha ba khanna makoloi le mekhoa ha ba ntse ba sebelisa lithethefatsi.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea Diabetalong:

miconazole e ntlafatsa haholo phello ea gliclazide,
phenylbutazone nakong ea tsamaiso ea methapo e khothaletsa ho falla ha gliclazide puisanong le liprotheine tsa plasma le / kapa e liehisa ho tsoa ha eona 'meleng, ho eketsa phello ea hypoglycemic ea lithethefatsi,
ethanol (ho kenyeletsa le joala le lithethefatsi tse nang le ethanol) e eketsa kotsi ea hypoglycemia, e ka baka komello ea hypoglycemic,
li-agents tse ling tsa hypoglycemic (insulin, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists), beta-blockers, fluconazole, angiotensin converting enzyme inhibitors (Captopril, blocktopril,₂- histamine receptors, monoamine oxidase inhibitors, sulfonamides ,cacithromycin, lithethefatsi tse seng khahlanong le steroidal - li eketsa phello ea hypoglycemic ea lithethefatsi le kotsi ea hypoglycemia,
Danazole o na le lefu la tsoekere, o fokotsa litlamorao tsa sethethefatsi,
Chlorpromazine ka tekanyo e kaholimo ho 100 mg ka letsatsi, e fokotsa sekhahla sa insulin, e eketsa bongata ba tsoekere maling.
tetracosactides le glucocorticosteroids bakeng sa ts'ebeliso ea kemiso le ea lihlooho li eketsa khatello ea tsoekere maling, li ka fokotsa mamello ea lik'habohaedreite 'me tsa baka nts'etsopele ea ketoacidosis,
salbutamol, ritodrin, terbutaline bakeng sa tsamaiso ea methapo ea methapo e eketsa boemo ba tsoekere maling.
warfarin le li-anticoagulants tse ling li ka ntlafatsa phello ea tsona.

Li-analog tsa Diabetesalong ke: Diabinax, Gliclazide MV, Gliclazide-Akos, Glidiab MV, Diabeteson MV, Glucostabil.

Ketso ea pharmacological

Oral hypoglycemic drug, e fumanoang molomong oa bobeli.

E tsosa secretion ea insulin ke manyeme, e theola boemo ba tsoekere maling, e ntlafatsa phello ea sephiri sa "insulin" 'me e phahamisa kutloisiso ea lisele tsa pherekano ho insulin. Kamora kalafo ea lilemo tse peli, bakuli ba bangata ha ba hlaole ba lekhoba la lithethefatsi (keketseho ea boemo ba insulin le secretion ea C-peptides e ntse e tsoela pele).

Fokotsa nako ea ho qalella ho tloha motsotso oa ho ja ho isa ho qala ho secretion. E khutlisetsa tlhoro ea pele ea "insulin secretion" ho arabela tekanyo ea tsoekere (ho fapana le lintho tse ling tse tsoang ho sulfonylurea, tse nang le phello e kholo nakong ea bobeli ea secretion). E boetse e ntlafatsa karolo ea bobeli ea seculin ea insulin. Fokotsa tlhoro ea hyperglycemia kamora ho ja (e fokotsa "hypprousial hyperglycemia").

Glyclazide e eketsa kutloisiso ea lithane tsa peripheral ho insulin (i.e., e na le phello e boletsoeng ea extrapancreatic). Ho mesifa ea mesifa, phello ea insulin mabapi le tsoekere ea tsoekere, ka lebaka la kutloisiso e ntlafalitsoeng ea lisele ho insulin, e eketseha haholo (ho fihla ho + 35%), hobane glycazide e phahamisa tšebetso ea mesifa ea glycogen synthetase.

Fokotsa sebopeho sa tsoekere maling, ho etsa hore boleng ba tsoekere bo potlakileng.

Ntle le ho ama metabolism ea carbohydrate, gliclazide e ntlafatsa microcirculation. Lithethefatsi li fokotsa kotsi ea thrombosis e nyane ea sekepe, e amang mekhoa e 'meli e ka amehang ho nts'etsopele ea mathata a lefu la tsoekere: ho thibela likarolo tsa methapo le ho khomarela le ho fokotseha ha lintho tse ngata tse amanang le tsamaiso ea liplatelete (beta-thromboglobulin, thromboxane B2), hammoho le pholiso fibrinolytic mosebetsi oa vasotine endothelium le tšebetso e eketsehileng ea tishu ea plasminogen activator.

Glyclazide e na le thepa ea antioxidant: e fokotsa sekhahla sa lipid peroxides ho plasma, e eketsa ts'ebetso ea diselutase ea mali a khubelu ea mali.

Ka lebaka la botle ba mofuta oa litekanyetso, lethal e le 'ngoe la matlapa a Diabetalong ® 30 mg ka letsatsi a fana ka phekolo e sebetsang ea "gliclazide" plasma ea mali ka lihora tse 24.

Mofumahali

Kamora ho tsamaisoa ka molomo, gliclazide e kenella ka botlalo ho tsoa ho tšilo ea lijo. Ho ja ha ho ame ho monya. Ho bokellana ha ntho e sebetsang plasma ea mali butle-butle ho eketseha butle-butle, ho fihla bonyenyaneng ebe ho fihla setsing sa lihora tse 6 ho isa ho tse tšeletseng ka mor'a ho nka moriana. Phapang ea motho ka mong e tlaase haholo. Kamano lipakeng tsa lethal dose le mokokotlo oa moriana ho plasma ea mali ke ho itšetleha ka nako ka nako.

Tsamaiso le metabolism

Plasma protein e tlamang ke hoo e ka bang 95%.

E tšeloa ka har'a sebete 'me e hloekisoa haholo ke liphio. Ha ho na metabolites e sebetsang ho plasma.

Excretion ke liphio e etsoa haholo ka sebopeho sa metabolites, ka tlase ho 1% ea lithethefatsi ha li sa fetoloa.

T 1/2 ke lihora tse 16 (lihora tse 12 ho isa ho tse 20).

Pharmacokinetics maemong a khethehileng a kliniki

Bathong ba tsofetseng, ha ho liphetoho tse bohlokoa tsa kliniki maemong a pharmacokinetic li bonoang.

Melemo ea litekanyetso

Setlhare se etselitsoe feela kalafo ea batho ba baholo.

Diabetesalong ® Matlapa a lokolotsoeng a 30 mg a nooa ka molomo nako e le 1 / letsatsi nakong ea lijo tsa hoseng.

Bakeng sa bakuli ba sa kang ba fumana kalafo (ho kenyelletsa le bakeng sa batho ba baholo ho feta lilemo tse 65), tekanyetso ea pele ke 30 mg. Ebe mokelikeli o khethoa ka bonngoe ho fihlela phello ea kalafo e lakatsehang e fihlelle.

Khetho ea moriana e lokela ho etsoa ho latela boemo ba tsoekere maling maling ka mor'a ho qala kalafo. Phetoho e 'ngoe le e' ngoe ea kokoana-hloko e latelang e ka etsoa kamora bonyane libeke tse peli.

Tekanyetso ea letsatsi le letsatsi ea lithethefatsi e ka fapana ho tloha ho 30 mg (1 tab.) Ho 90-120 mg (3-4 tab.). Tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 120 mg (matlapa a 4).

Diabetesalong ® e ka nkela matlapa a tloaelehileng a gliclazide (80 mg) litekanyetso tsa matlapa a 1 ho isa ho a 4.

Haeba u fetoa ke tekanyetso e le 'ngoe kapa tse' maloa tsa moriana, u ke ke ua nka tekanyetso e phahameng ka tekanyetso e latelang (ka le hlahlamang).

Ha u nkela lithethefatsi tse ling tsa hypoglycemic lipilisi tsa Diabetalong ® 30 mg, ha ho hlokahale nako ea phetoho. U lokela ho qala ka ho khaotsa ho sebelisa tekanyetso ea letsatsi le letsatsi ea lithethefatsi tse ling ebe ka letsatsi le hlahlamang qala ho sebelisa moriana ona.

Haeba mokuli a kile a fumana kalafo ka sulfonylureas e nang le bophelo bo bolelele ba bophelo, ho hlokahala hore ho be le tlhokomelo ka hloko (ho lekola tsoekere ea mali) bakeng sa libeke tse 1-2 ho latela sephetho sa litlamorao tsa kalafo e fetileng.

Diabetesalong ® e ka sebelisoa hammoho le biguanides, alpha-glucosidase inhibitors kapa insulin.

Bakeng sa bakuli ba nang le bothata ba ho hlaphoheloa ke liphekolo tse bonolo le tse itekanetseng, moriana o laoloa ka tekanyetso e lekanang le ea bakuli ba nang le ts'ebetso e tloaelehileng ea fig. Ha e sa sebetse hantle hantle haholo ke lefu la tsoekere, "Diabetesalong ®" e tšoaetsanoa.

Ho bakuli ba kotsing ea ho ba le hypoglycemia (phepo e sa lekaneng kapa e sa leka-lekanang, mathata a endocrine a tebileng kapa a sa sebetseng hantle - ho hloka khaello ea phepo le adrenal, hypothyroidism, ho hlakoloa ha glucocorticosteroids kamora ho tsamaisoa ha nako e telele le / kapa tekanyetso e phahameng, mafu a matla a tsamaiso ea methapo ea pelo / IHD e matla, carotid arteriosulinosis e matla, atherosulinosis e atileng /) ho khothalletsoa ho sebelisa tekanyetso e fokolang (30 mg 1 nako / letsatsi) ea moriana Diabetalong ®.

Litla-morao

Hypoglycemia (e khahlanong le regimen ea dosing le lijo tse sa lekaneng): hlooho ea hlooho, mokhathala o eketsehileng, tlala, ho fufuleloa ho eketsehileng, bofokoli bo matla, ho akheha, ho ferekana, khatello ea mali, ho otsela, ho hloka boroko, ho ruruha, ho teneha, ho teneha, ho hloka kelello, ho hloka tlhokomelo e tlase, ho se khonehe tsepamisa maikutlo le ho lieha ho arabela, khatello ea maikutlo, pono e sa sebetseng, ho ferekana, ho thothomela, pherese, ho ferekana kelellong, ho tsekela, ho ikutloa u se na thuso, ho lahleheloa ke boitšoaro, ho hlasimoloha, ho tsitsipana, ho se tsitse ea e respiration, bradycardia, utloe letho, coma.

Ho tsoa ho ts'ilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, bohloko ba ka mpeng, ho sokela (ho teba ha matšoao ana ho fokotseha ha ho nkuoa ka lijo), ka seoelo - ts'oaetso ea sebete (hepatitis, mosebetsi o eketsehileng oa hepatic transaminase, alkaline phosphatase, cholestatic jaundice - e hloka ho tlosoa hoa lithethefatsi).

Ho tsoa lithong tsa hemopoietic: thibelo ea masapo a hematopoiesis (anemia, thrombocytopenia, leukopenia, granulocytopenia).

Litla-morao tsa ho nyekeloa: ho hlohlona ha letlalo, urticaria, lekhopho la letlalo, ho kenyeletsa maculopapular and bullous), erythema.

Tse ling: ho sitisoa ha pono.

Litla-morao tse tloaelehileng tsa derivatives ea sulfonylurea: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, alculgic vasculitis, ho se sebetse hantle hoa sebete.

Bokhachane le pelehi

Ha ho na boiphihlelo ka gliclazide nakong ea kemolo. Lintlha tse mabapi le tšebeliso ea tse ling tse tsoang sulfonylurea nakong ea kemaro li na le moeli.

Boithutong ba liphoofolo tse sebelisoang ka laboratoring, litla-morao tsa "gliclazide" ha li so tsejoe.

Ho fokotsa kotsi ea tšoaetso ea tlhaho ea tlhaho, ho hlokahala hore ho laoloe hantle (kalafo e nepahetseng) ea lefu la tsoekere.

Lithethefatsi tsa molomo tsa molomo nakong ea kemolo ha li sebelisoe. Moriana oa khetho bakeng sa kalafo ea lefu la tsoekere ho basali baimana ke insulin. Ho khothalletsoa ho nka sebaka sa ts'ebeliso ea lithethefatsi tsa molomo tsa hypoglycemic ka kalafo ea insulin ka bobeli nakong ea kemaro e reriloeng, le hore na ho ima ho etsahetse ha u ntse u sebelisa moriana.

Ka ho nahana ka ho haella ha tlhaiso-leseling mabapi le tšebeliso ea gliclazide ka lebese la matsoele le kotsi ea ho ba le neonatal hypoglycemia, letsoele le hanyetsoa nakong ea kalafo ea lithethefatsi.

Bongata

Matšoao: hypoglycemia, ho akheha ka letsoalo, ho ferekana kelellong.

Phekolo: haeba mokuli a hlokahalletse, nka tsoekere kahare.

Mohlomong nts'etsopele ea maemo a matla a hypoglycemic, e tsamaeang le komisi, ho akheha kapa mathata a mang a methapo ea methapo. Haeba matšoao a joalo a hlaha, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka le ho kena sepetlele hang-hang.

Haeba hypoglycemic coma e belaelloa kapa e fumanoa, 50 ml ea tharollo ea glucose ea 40% e kenella ka potlako ho mokuli. Ebe tharollo ea 5% dextrose (glucose) e fanoa ka har'a methapo e le hore ho boloka sekhahla se hlokahalang sa tsoekere maling.

Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite tse bonolo tse tsoang habonolo (molemong oa ho qoba tsoelopele ea hypoglycemia). Ho lekola ka hloko maemo a tsoekere ea mali le ho hlahloba mokuli ho lokela ho etsoa bonyane lihora tse 48 tse latelang. Kamora nako ena ea nako, ho latela boemo ba mokuli, ngaka e eang e nka qeto ea tlhoko ea tlhahlobo e ngoe hape.

Ho buoa ka methapo ha ho na thuso ka lebaka la ho tlangoa ha gliclazide liprotheine tsa plasma.

Sebopeho le mofuta oa tokollo

Matlapa - Letlapa le le leng:

Lintho tse sebetsang: glyclazide - 30 mg, Excipients: hypromellose (Metocel K-100 LV CR Premium), colloidal silicon dioxide (aerosil), calcium stearate, talc, lactose monohydrate (matlapa a 80).

Moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli. E hlohlelletsa secretion ea insulin ke lisele tsa β-tsa manyeme. Eketsa kutloisiso ea lisele tsa peripheral ho insulin. Kamoo ho bonahalang kateng, e matlafatsa ts'ebetso ea li-enzyme tse ka hare (haholo-holo, mesifa ea glycogen synthetase). Fokotsa nako ea ho qalella ho tloha motsotso oa ho ja ho isa ho qala ho secretion. E khutlisa tlhoro ea pele ea "insulin secretion", e fokotsa tlhoro ea "hyperglycemia" ea postprandial.

Glyclazide e fokotsa khokahano ea liplatelete le ho kopana, e liehisa nts'etsopele ea "parietal thrombus", 'me e eketsa ts'ebetso ea methapo ea methapo. Normalizing ho hlaphoheloa ha methapo ea pelo. E na le thepa ea anti-atherogenic: e theola khatello ea cholesterol e felletseng (Ch) le LDL-C maling, e eketsa bongata ba HDL-C hape e fokotsa lenane la li-radicals tsa mahala. E thibela nts'etsopele ea micothrombosis le atherosclerosis. E ntlafatsa microcirculation. E fokotsa kutloisiso ea methapo ho adrenaline.

Ka lefu la tsoekere le lefu la tsoekere le tšebeliso ea nako e telele ea gliclazide, ho bonahala phokotseho e kholo ea proteinuria.

Kamora ho tsamaisoa ka molomo, e kenella ka potlako ho tsoa mokokotlong oa lijo. C max maling e fihlella lihora tse ka bang 4 ka mor'a ho nka tekanyetso e le 'ngoe ea 80 mg.

Plasma protein e tlamang ke 94.2%. V d - hoo e ka bang 25 l (0,35 l / kg boima ba mmele).

E tšelisoa ka har'a sebete ho hlaha metsoako e robeli ea metsoako. Metabolite ea mantlha ha e na phello ea hypoglycemic, empa e na le phello ho microcirculation.

Lihora tsa T1 / 2-12. E pepisoa haholo ke liphio ka mokhoa oa metabolites, e ka tlase ho 1% e pepesitsoeng ka har'a moroto o sa fetoheng.

Setlhare sa molomo sa hypoglycemic.

Gliclazide e sebelisetsoa ho alafa mellitus e sa itšetleheng ka insulin hammoho le lijo tse nang le khalori e tlase e tlaase.

Nakong ea kalafo, o lokela ho lekola khafetsa boemo ba tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja, ho fetoha ha maemo a letsatsi le letsatsi ka bongata.

Maemong a ts'ebetso ea ts'ebetso ea bongaka kapa ho bola ha lefu la tsoekere, ho hlokahala hore u nahane ka monyetla oa ho sebelisa litokisetso tsa insulin.

Ka nts'etsopele ea hypoglycemia, haeba mokuli a le teng, ho na le glucose (kapa tharollo ea tsoekere) kahare. Bakeng sa tahlehelo ea kelello, glucose e kenang kapa glucagon sc, intramuscularly kapa intravenous e tsamaisoa. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite e le ho qoba tsoelopele ea hypoglycemia.

Ka ts'ebeliso e ts'oanang ea gliclazide e nang le verapamil, ho hlokahala hore ho hlahlojoe litekanyetso tsa tsoekere ea mali kamehla, ka acarbose, ho lekola ka hloko le ho khalemela litekanyetso tsa litekanyetso tsa li-hypoglycemic agents.

Tšebeliso e tšoanang ea gliclazide le cimetidine ha e khothalletsoe.

Matlapa a Sirelelitsoeng a Kholisitsoeng, 30 mg

Letlapa le leng le na le

ntho e sebetsang ke gliclazide - 30 mg,

excipients: hypromellose, colloidal silicon dioxide, calcium tsoele, talc, lactose monohydrate

Matlapa a tšoeu kapa a batla a soeufetse, a boreleli, a na le bevel. Marbling e lumelletsoe

Melemo ea pharmacological

Kamora ho tsamaisoa ka molomo, gliclazide e kenella ka botlalo ho tsoa pampiring ea gastrointestinal. Ho ja ha ho ame ho monya. Ho bokellana ha ntho e sebetsang plasma ea mali butle-butle ho eketseha butle-butle, ho fihla bonyenyaneng ebe ho fihla setsing sa lihora tse 6 ho isa ho tse tšeletseng ka mor'a ho nka moriana. Phapang ea motho ka mong e tlaase haholo. Kamano lipakeng tsa lethal dose le mokokotlo oa moriana ho plasma ea mali ke ho itšetleha ka nako ka nako.

Puisano le liprotheine tsa plasma ke hoo e ka bang 95%.

E tšeloa ka har'a sebete 'me e hloekisoa haholo ke liphio. Excretion ke liphio e etsoa haholo ka sebopeho sa metabolites, ka tlase ho 1% ea lithethefatsi ha li sa fetoloa.

Ha ho na metabolites e sebetsang ho plasma. Bophelo ba halofo ke hoo e ka bang lihora tse 16 (lihora tse 12 ho isa ho tse 20).

Bathong ba tsofetseng, ha ho liphetoho tse bohlokoa tsa kliniki maemong a pharmacokinetic li bonoang.

Diabetalong® ke moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli.

Fokotsa sebopeho sa tsoekere maling, ho etsa hore boleng ba tsoekere bo potlakileng.

Ntle le ho ama metabolism ea carbohydrate, gliclazide e ntlafatsa microcirculation. Lithethefatsi li fokotsa kotsi ea thrombosis e nyane ea sekepe, e susumetsa mekhoa e 'meli e ka amehang ho nts'etsopele ea mathata a lefu la tsoekere: karohano e sa lekanyetsoang ea lintho tse kopanyang liplatelete le ho khomarela le ho fokotseha hoa khatello ea lintlha tsa ts'ebetso ea liplatelete (beta-thromboglobulin, thromboxane B2), hammoho le ho khutlisetsoa ha methapo ea methapo. vascular endothelial shughuli le tšebetso e eketsehang ea activator ea plasminogen.

Glyclazide e na le thepa ea antioxidant: e fokotsa sekhahla sa lipid peroxides ho plasma, e eketsa ts'ebetso ea diselutase ea mali a khubelu ea mali.

Ka lebaka la ho ikhetholla ha sebopeho sa litekanyetso, litekanyetso tsa letsatsi le letsatsi tsa matlapa a Diabetalong® 30 mg li fana ka kalafo e sebetsang ea "gliclazide" plasma ea mali ka lihora tse 24.

Sebopeho, foromo ea tokollo

Diabetesalong e fumaneha ka tsela ea matlapa a tšoeu a chitja. Li tletse mekotla ea likotoana tse 10 le lebokose la karete, moo ho nang le lipalo tse 3 ho isa ho tse 6.

Setlhare se fumaneha ka litekanyetso tse peli: 30 mg le 60 mg ea ntho e sebetsang, e leng gliclazide.

Likarolo tse thusang tsa sethethefatsi:

colloidal silicon dioxide,
lactose monohydrate,
calcium stearate
pyromellose
talcum phofo.

Foromo ea litekanyetso e ka ba ka mokhoa oa matlapa a nang le tlhahiso e lokisitsoeng kapa ka ketso ea nako e telele.

Pharmacology le pharmacokinetics

Motsoako o ka sehloohong oa ts'ebetso ke gliclazide, ka tlhaho ea lik'hemik'hale e tsoa ho sulfonylurea ea bobeli. Gliclazide e bonts'a ts'ebetso e phahameng ea ho khetha le bioavailability.

E hanyetsana le libaka tse fapaneng tsa tlhaho mme e na le litlamorao tse latelang:

e eketsa tlhahiso ea insulin ea hau, e u lumella ho fokotsa tekanyetso ea li-hormone tse tsoang,
normalizing metabolism ea carbohydrate,
e eketsa tšebetso ea lisele tsa pancreatic beta,
e fokotsa masapo a mmele, a thibelang thrombosis le li-pathologies tse ling tsa methapo.

Diabetesalong e kenella ka botlalo ka mor'a taolo. Butle-butle ho bokella maling, ho fihla maemong a mangata kamora lihora tse 4-6 kamora ts'ebetso, ho bonts'a phello ea eona bakeng sa lihora tse 10-12, ebe khatello ea eona e fokotseha haholo mme kamora lihora tse 12 moriana o tlosoe ka botlalo mmeleng.

Gliclazide e tšeloa haholo-holo ke sebete, 'me e entsoe ke liphio.

Matšoao le contraindication

Lebaka la ho nka lefu la tsoekere ke tlhahlobo ea mokuli - lefu la tsoekere la mofuta oa 2. Moriana o laetsoe ho theola tsoekere ea mali ha ho latela lithibelo tsa lijo tse khothalletsoang.

Hape, moriana o fanoa e le prophylactic bakeng sa mathata a bakoang ke lefu la tsoekere, haholo-holo liphetoho sebopeho sa methapo ea mali tlasa ts'usumetso ea "glycemia" e phahameng.

Ho na le li-contraindication bakeng sa moriana, li kenyeletsa:

mofuta oa 1 lefu la tsoekere
ho nka miconazole,
ho hloleha ho matla ha hepatic le renal,
nako ea kemaro le kanyeso,
ho ba teng ha lefu la tsoekere ketoacidosis, komisi kapa thoroma,
kutloisiso e phahameng ea likarolo tse etsang moriana,
tlolo ea metabolism ea lactose,
lilemo ho isa ho motho e moholo.

Tlhokomeliso mme e sebelisoa feela ke tlhokomelo ea ngaka, moriana o sebelisoa:

botsofaling
batho bao lijo tsa bona li sa hlakoheng,
bakuli ba nang le liso tsa pelo
bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase,
kamora kalafo ea nako e telele ea glucocorticosteroid,
lekhoba la tahi
ho ba le ho hloleha ha meno kapa sebete.

Maemong ana, ngaka e tlameha ho etsa qeto motheong oa data e fumanehang.

Lintho tsa video tse tsoang ho li-pharmacologists:

Litaelo tsa ho sebelisoa

Tekanyetso le khafetsa tsa tšebeliso ea Diabetalong li laetsoe ke ngaka, li ipapisitse le methati ea mokuli mme li ka fapana haholo ho tloha ho motho ho ea ho motho.Ho latela litaelo, kamohelo e etsoa makhetlo a 1-2 ka letsatsi metsotso e 20 pele ho lijo. Mokhoa ona o tla lumella tšebeliso e nepahetseng ea thepa ea gliclazide.

Setlhare se nooa ka molomo ebe sea hlatsuoa ka metsi a manyane. Tekanyetso e khethoa ke mokhoa oa khetho. Maemong ana, o lokela ho qala ka 30 mg ka letsatsi, haeba ho se na kalafo e tlatselletsang, litekanyetso li eketsa butle-butle ka 30 mg ho isa ho 120 mg. Ena ke tekanyetso e phahameng kaholimo e sa sebelisoeng ts'ebeliso.

U ke ke ua eketsa litekanyetso ka ho ikemela haeba e 'ngoe ea mekhoa e ne e hlotsoe, kaha lithethefatsi li lebisa ho fokotseha ha tsoekere ea mali, e ka lebisang ho hypoglycemia.

Bakuli ba khethehileng

Bakeng sa batho ba baholo ba fetang 65, ho ka hlokahala phetoho ea litekanyetso. Ka kakaretso, moriana o sebelisoa ho latela melao e ts'oanang.

Nakong ea kemaro, moriana o khothalletsoa hore o nkeloe phekolo ea insulin ho fihlela pelehi. Ha ho na boiphihlelo ka tšebeliso ea lefu la tsoekere le lithethefatsi tse ling tse thehiloeng glycoside nakong ea kemolo, ka hona ho ke ke ha khonahala ho tseba hore na phello ea eona ke efe ho lesea.

Nakong ea lebone, sethethefatsi le sona ha se khone ho sebelisoa, hobane ho na le monyetla oa ho holisa neonatal hypoglycemia ho ngoana. Ka hona, ho anyesa mosali ea kulang ho thibetsoe.

Bakuli ba nang le bothata ba ho phekoloa ka methapo le methapo e meng ea methapo ba lokela ho latela litekanyetso tse tlase, haholo-holo, ba lokela ho lula ba beiloe leihlo ke ngaka e ba teng.

Ho sebelisana le meriana e meng

Diabetesalong e sebelisana ka mafolofolo le lintho tse ngata, ka hona, pele u e nka, u lokela ho tloaela ntlha ena.

Kahoo, haeba o ka sebetsa ka nako e le 'ngoe:

ka joala bo ka baka hypoglycemia,
le Danazol, phello ea lefu la tsoekere e bonahatsoa, e fokotsang phello ea lithethefatsi,
ka miconazole, phello ea gliclazide e matlafalitsoe, e ka tlatsetsang ho theheng ha hypoglycemia, ntho e tšoanang e etsahala le baemeli ba bang ba hypoglycemic,
le chlorpromazine, e fokotsang tlhahiso ea insulin, ts'ebetso ea lithethefatsi e fokotsehile haholo,
ka tetracosactide le glucocorticosteroids ho ka lebisa nts'etsopele ea ketoacidosis le ho fokotseha ha mamello ea carbohydrate,
le Wafarin le li-coagulants tse ling li ntlafatsa phello ea eona.

Tlhahlobo ea lingaka e bonts'a hore Diabetesalong e sebetsa hantle haholo ho fokotsa tsoekere ea mali, leha ho le joalo, e ke ke ea sebelisoa kamehla.

Maemong ana, ho fanoa ka li-analogues tsa Diabetesalong, tse ngata haholo:

Diabetesalong le Diabeteson li ntshetswa pele motheong oa motsoako o tšoanang, empa moriana oa bobeli o nkuoa o sebetsa hantle ho feta, hobane phello ea ketso ea ona e fihlella ka potlako, empa theko ea sethethefatsi sena e phahame makhetlo a mabeli. Glyclazide ke analogue e batlang e felletse.

Glucophage nako e telele e na le metformin ka sebopeho sa eona mme e ka kopanngoa le insulin le lithethefatsi tse ling ho theola tsoekere ea mali.