Litaba tsa tlhokomelo ea bophelo bo botle

Batho ba bang ba tsoekere ba lefu la tsoekere ba na le mathata a ho robala, ka lebaka leo, ba hloka ho khetha lipilisi tsa ho robala. Ho hlaha lipuisano mabapi le tšebeliso ea lefu la tsoekere la Mofuta oa 1 le mofuta oa 2.

Litaelong tsa ho sebelisa lithethefatsi ena, e 'ngoe ea litšitiso ke bolwetse bona. Ho lumeloa hore Melaxen e ka fokotsa kapa ea eketsa tsoekere ea mali. Empa lingaka tse ling tsa lefu la tsoekere li nka pilisi ena ea ho robala 'me ha e lle ka boemo ba hypo- kapa hyperglycemia. Ha e le hantle ho etsahalang 'meleng oa motho ea nang le lefu la tsoekere ka mor'a ho sebelisa moriana?

Maikutlo a fapana ka moriana ona. Empa, leha ho le joalo, ha re bua ka liphetho tsa lithuto tse phetoang, re ka fihlela qeto ea hore, bonyane, lithethefatsi Melaxen ha li ame hampe 'mele oa motho ka lefu la tsoekere la mofuta oa 2 kapa lefu la tsoekere. Karolo ea eona e sebetsang, melatonin, ke hormone ea bohlokoa e laolang lits'ebetso tse ngata 'meleng oa motho, haholo-holo biorhythms.

Ka hona, ho qoba kotsi e ka bang teng, ho molemo ho buisana le ngaka ea hau pele u sebelisa lipilisi tsa ho robala. O tla tseba ho hlahloba hore na ho na le monyetla oa ho sebelisa lithethefatsi le ho beha moriana o nepahetseng.

Tlhahisoleseling ka lithethefatsi Melaxen

Setlhare sena se sebelisetsoa ho khathatseha boroko le ho etsa joalo ka adaptara ho tsitsisa biorhythm, mohlala, nakong ea maeto. Melaxen e hlahisoa ka mokhoa oa matlapa, e 'ngoe le e' ngoe e nang le melatonin (3 mg), hammoho le likarolo tse ling - magnesium stearate, microcrystalline cellulose, phosphate ea calcium hydrogen, shellac, talc le isopropanol.

Melatonin ke lihormone tse kaholimo ho sebopeho sa lintho tsa tlhaho le molaoli oa lipina tsa circadian (circadian). Nakong ea kholo ea eona kapa ts'ebeliso ea eona e le moriana, melatonin e etsa mesebetsi e joalo 'meleng oa motho:

• e fokotsa khatello ea maikutlo, kelellong le maikutlong,
• e ama tsamaiso ea endocrine (haholoholo, e thibela sephiri sa gonadotropins),
• Ho fokotsa khatello ea mali le ho robala hangata,
• e eketsa tlhahiso ea antibody,
• antioxidant, ho isa boholeng bo itseng
• e ama tloaelo nakong ea liphetoho tse etsahalang maemong a leholimo le a nako,
• e laola tšilo ea lijo le tšebetso ea boko,
• e lieha ho tsofala le ho feta.

Tšebeliso ea lithethefatsi Melaxen e kanna ea haneloa eseng feela ka lebaka la lefu la tsoekere la mofuta oa 2, empa hape le ho ba teng ha litlolo tse ling.

1. ho hloka mamello ho likarolo,
2. Monyenyo le nyetso
3. ho se sebetse hantle ha renal le ho se sebetse hantle ha renal,
4. autoimmune pathologies,
5. lefu la sethoathoa (lefu la neurological),
6. myeloma (hlahala e mpe e tsoang plasma ea mali),
7. lymphoganulomatosis (malignant pathology ea lisele tsa methapo),
8. lymphoma (swphlen lymph node),
9. leukemia (mafu a kotsi a hematopoietic system),
10. allergy

Maemong a mang, lithethefatsi li khona ho baka ka lebaka le itseng litlamorao tse mpe tse kang:

• ho otsela hoseng le hlooho e bohloko,
• ho ferekana kelellong (ho nyekeloa, ho hlatsa, lets'ollo la lefu la tsoekere),
• ho tsitsinyeha hoa mmele (ho ruruha).

Melaxen e ka rekoa k'hemisteng ntle le taelo ea ngaka. Mmarakeng oa meriana ea Russia le ho na le li-analogu tsa teng - Melarena, Circadin, Melarithm.

Leha ho le joalo, tlhahlobo ea lingaka e ke ke ea e-ba ea bohlokoa haholo, haholo ha motho ea tloaelehileng kapa lefu la tsoekere a tšoeroe ke mafu a mang.

Mehopolo

Haeba o na le lefu la tsoekere le nahanang ho nka melatonin, etela ngaka ea hau ho bona hore na ho na le mathata afe kapa afe ao u lokelang ho a hlokomela. Ngaka ea hau e tla nahana ka mofuta oa hau oa lefu la tsoekere, nalane ea bongaka le lintlha tse ling ho tla ka tlhahiso. American Diabetes Association e bontša hore litla-morao, ho sebetsa hantle, tšebelisano ea lithethefatsi, le tlhaiso-leseling e nepahetseng ea mefuta ena ea lithethefatsi le litlatsetso ha e utloisoe hantle ka linako tsohle, kahoo ho molemo ho batla litlhare tse ling bakeng sa mathata a hau a ho robala.

Halo melatonin e sebetsa joang?

Melatonin ke Hormone e ka sehloohong e hlahisang 'mele oa hae ka har'a pineal gland. Tlhahiso ea eona e bakoa ke tahlehelo ea ho chabeloa ha leseli ho retina. Kahoo, e bonts'a nako ea letsatsi, 'me e laola lipina tsa circadian. E boetse e ama ho feto-fetoha ha mocheso oa potoloho ea methapo ea litho tsa 'mele le lisele tsa' mele tse fapaneng, ho fetola morethetho oa circadian.

Kannete, taolo ea morethetho oa circadian maemong a 'maloa, ho kenyeletsoa cells - lisele, e kentse letsoho taolong ea metabolic, le ntlafatsong ea lefu la tsoekere la mofuta oa 2. Hormone e fetisetsa lipontšo sethaleng ka ho sebelisa li-receptor tse peli: (MT1) le (MT2). Li-receptor ka bobeli li sebetsa haholo ka protheine ea Gcyi, e theola boemo ba cAMP ka ho thibela liprotheine tsa G (G I), empa ho boetse ho sebelisoa mekhoa e meng ea ho saena. Pleiotropism maemong a li-receptor ka bobeli le sesebelisoa sa bobeli sa ho saena. Sena se hlalosa hore na hobaneng litlamorao tse hlahisitsoeng ka ho lokolloa ha insulin li sa fane ka kutloisiso e hlakileng ea karolo ea taolo ea melatonin ho secretion ea insulin. Kahoo, ho tlalehiloe hore ho na le lithibelo tse thibelang le tse hlasimollang tsa hormone ena hore li ama secretion ea insulin.

Boithuto bo bontšitse:

Khahlano le semelo sena, re fumane hore mofuta oa MTNR1B (MT2) o amahanngoa le boemo bo phahameng ba glucose ea glu. Ho fokotseha ha karabelo ea pele ea insulin ka tsamaiso ea methapo ea methapo, ho senyeha ka potlako ho secretion ea insulin ka mor'a nako, le kotsi e eketsehang ea ho ba le lefu la tsoekere la mofuta oa 2 nakong e tlang. Leha ho na le kamano e phahameng haholo ea liphatsa tsa lefutso, kutloisiso ea limolek'hule ea hore na ke hobaneng ha melatonin ho kenella pathogeneis ea mofuta oa 2 lefu la tsoekere ha e so fihlelle.

Ho rarolla bothata bona, re ile ra etsa liteko tsa liteko lefapheng la batho - lisele le litoeba, hammoho le lithuto tsa bongaka ho batho. Ho ile ha fumaneha hore menyetla e fapaneng ea maemo a kotsi e leng kotsi ea 10830963 ho tloha MTNR1B ke polelo ea litšobotsi tse ngata (eQTL) e fanang ka polelo e eketsehang ea MTNR1B mRNA lihlekehlekeng tsa batho. Liteko tsa INS-1 832/13 β-lisele le MT2 ea litoeba tsa teko (Mt2 - / -) li fumane hore thibelo ea molatonin ea qoqotho e ama ka kotloloho tlhahiso ea insulin.

Lithuto tsa batho li bontša hore kalafo ea melatonin e thibela secretion ea insulin ho bakuli bohle. Empa bajari ba mofuta o kotsi ba amehile haholo ka phello ena ea thibelo. Ka bobeli, lipatlisiso tsena li tšehetsa mohlala oo ka oona keketseho ea liphatsa tsa lefutso ea melatonin e tšoaeang secretion ea insulin. Ho ferekana ho kenyang matšoao a lefu la tsoekere la mofuta oa 2.

Sengoloa sa sengoloa sa mahlale mabapi le bongaka le tlhokomelo ea bophelo bo botle, mongoli oa pampiri ea saense - Konenkov Vladimir Iosifovich, Klimontov Vadim Valerievich, Michurina Svetlana Viktorovna, Prudnikova Marina Alekseevna, Ishenko Irina Yurievna

Hormone ea pineal gland melatonin e tiisa ho hokahana ha insulin secretion le gluostose homeostasis ka khanya e sa fetoheng le nako e lefifi ea letsatsi. Tlolo ea tumellano lipakeng tsa melatonin-Mediated circadian rhythms le secretion ea insulin e bonoa mofuteng oa 1 le mofuta oa 2 lefu la tsoekere mellitus (T1DM) le T2DM. Khaello ea insulin mofuteng oa 1 oa lefu la tsoekere e tsamaisana le keketseho ea tlhahiso ea melatonin tšoelesa ea phaene. T2DM, ka lehlakoreng le leng, e tšoauoa ka ho fokotseha ha secattion ea melatonin. Lithutong tse akaretsang tsa genome, mefuta e fapaneng ea melatonin MT2 receptor gene (rs1387153 le rs10830963) e amana le ho itima lijo ha glycemia, β-cell function, le mofuta oa 2 lefu la tsoekere. Melatonin e eketsa ho eketseha ha β-cell le neogeneis, e ntlafatsa kutloisiso ea insulin hape e fokotsa khatello ea maikutlo ka hara retina le liphio mehlaleng ea lefu la tsoekere. Ho hlokahala lithuto tse ling hape ho lekola boleng ba kalafo ba li-hormone bona ho bakuli ba nang le lefu la tsoekere.

Melatonin le lefu la tsoekere: ho tloha ho pathophysiology ho ea ho pono ea kalafo

Pineal hormone melatonin e hokahanya secretion ea insulin le homeostasis ea glucose le linako tsa letsatsi. Ho se lumellane pakeng tsa melatoninmediated circadian rhythms le insulin secretion e tšoaea mofuta oa lefu la tsoekere 1 (T1DM) le mofuta oa 2 (T2DM). Khaello ea insulin ho T1DM e tsamaisana le tlhahiso e eketsehileng ea melatonin. Ka lehlakoreng le leng, T2DM e tšoauoa ka secretion ea melatonin e fokotsehileng. Lithutong tse kopaneng tsa genome wide variants of melatonin receptor MT2 gene (rs1387153 le rs10830963) li ne li amahanngoa le glucose ea ho itima lijo, beta-cell function le T2DM. Mefuteng ea teko ea lefu la tsoekere melatonin e ntlafalitseng ho eketseha ha beta-cell le neogeneis, ho hanyetsa insulin le ho kokobetsa khatello ea oxidative ho retina le liphio. Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng ho lekola boleng ba kalafo ba melatonin ho bakuli ba lefu la tsoekere.

Sengoloa sa mosebetsi oa mahlale ka sehlooho "Melatonin ho lefu la tsoekere: ho tloha ho pathophysiology ho ea ho litebello tsa kalafo"

Melatonin a lefu la tsoekere: ho tloha ho pathophysiology ho ea ho litebello tsa kalafo

Konenkov V.I., Klimontov V.V., Michurina S.V., Prudnikova M.A., Ischenko I.Yu.

Setsi sa Patlisiso sa Tleliniki le Tlhahlobo ea Bohloeki, Novosibirsk

(Motsamaisi - Setsebi RAMNV.I. Konenkov)

Hormone ea pineal gland melatonin e tiisa ho hokahana ha insulin secretion le gluostose homeostasis ka khanya e sa fetoheng le nako e lefifi ea letsatsi. Tlolo ea tumellano lipakeng tsa melatonin-Mediated circadian rhythms le secretion ea insulin e bonoa mofuteng oa 1 le mofuta oa 2 lefu la tsoekere mellitus (T1DM) le T2DM. Khaello ea insulin mofuteng oa 1 oa lefu la tsoekere e tsamaisana le keketseho ea tlhahiso ea melatonin tšoelesa ea phaene. T2DM, ka lehlakoreng le leng, e tšoauoa ka ho fokotseha ha secattion ea melatonin. Lithutong tsa genomic e felletseng, mefuta e fapaneng ea melatonin MT2 receptor gene (rs1387153 le rs10830963) e amahanngoa le ho itima lijo ha glycemia, ts'ebetso (i-cell le CD2. Melatonin e eketsa kutloisiso le ho fokotsa khatello ea methapo ea methapo methapong ea menoana le methapo. mefuta ea liteko tsa lefu la tsoekere Ho lekola boleng ba kalafo ba hormone ena ho bakuli ba nang le lefu la tsoekere, ho hlokahala lithuto tse ling hape.

Mantsoe a bohlokoa: lefu la tsoekere, melatonin, morethetho oa liserekisi, insulin, lefu la pineal

Melatonin le lefu la tsoekere: ho tloha ho pathophysiology ho ea ho pono ea kalafo

Konenkov V.I., Klimontov V.V., Michurina S.V., Prudnikova M.A., Ishenko I.Ju.

Setsi sa Patlisiso sa Tleliniki le Teko ea Lymphology, Novosibirsk, Russia Federation

Pineal hormone melatonin e hokahanya secretion ea insulin le homeostasis ea glucose le linako tsa letsatsi. Ho se lumellane pakeng tsa melatonin-mediated circadian rhythms le insulin secretion e tšoaea mofuta oa lefu la tsoekere 1 (T1DM) le mofuta oa 2 (T2DM). Khaello ea insulin ho T1DM e tsamaisana le tlhahiso e eketsehileng ea melatonin. Ka lehlakoreng le leng, T2DM e tšoauoa ka secretion ea melatonin e fokotsehileng. Lithutong tse kopaneng tsa genome wide variants of melatonin receptor MT2 gene (rs1387153 le rs10830963) li ne li amahanngoa le glucose ea ho itima lijo, beta-cell function le T2DM. Mefuteng ea teko ea lefu la tsoekere melatonin e ntlafalitseng ho eketseha ha beta-cell le neogeneis, ho hanyetsa insulin le ho kokobetsa khatello ea oxidative ho retina le liphio. Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng ho lekola boleng ba kalafo ba melatonin ho bakuli ba lefu la tsoekere.

Mantsoe a bohlokoa: lefu la tsoekere, melatonin, morethetho oa li-circadian, insulin, epiphysis

Li-biorhythms tsa endocrine system, hammoho le liphetoho tsa bona maemong a pathology, li hohetse tlhokomelo ea bafuputsi ka mashome a lilemo. Ntho e khahlisang haholo thutong ea lefu la tsoekere mellitus (DM) ho latela pono ea chronomedicine ke molumo oa pineal gland melatonin. Hormone ena e bapala karolo ea bohlokoa ho hokahanyang ha litheko tsa lihormone le lits'ebetso tsa metabolic le phetoho ea khanya le lefifi. Lilemong tsa morao tjena, ho fumanoe lintlha tse ncha tse mabapi le karolo ea melatonin taolong ea insulin secretion le pathophysiology ea carbohydrate metabolism, le tebello ea ts'ebeliso ea melatonin bakeng sa kalafo ea lefu la tsoekere. Kakaretso ea tlhaiso-leseling ena e ne e le sepheo sa tlhahlobo ena.

Secretion le litlamorao tsa mmele tsa 'mele tsa melatonin

Homo melatonin e ile ea qheleloa ka thoko ho bovine pineal gland lintho ka 1958. Melatonin e thehoa ho tloha L-tryptophan ka serotonin ka ho nka karolo ha arylalkylamine ^ acetyltransferase (AA-NAT, enzyme ea melao ea tsamaiso) le hydroxyindole-O-methyltransferase. Ho motho e moholo, li-mcg tse ka bang 30 li entsoe ka letsatsi

melatonin, ho kenella ha eona serumong ea mali bosiu ho atile makhetlo a 20 ho feta motšehare. Lerata le potoloha la melatonin synthesis le laoloa ke "suprachiasmatic nucleus" (SCN) ea hypothalamus. Ho fumana leseli ka liphetoho tse khantšang ho retina, SCN e fetisetsa lipontšo ho sehlopha se phahameng sa kutloelo-bohloko ea litho tsa mokokotlo le likhoele tse bohloko tsa pineal gland. Ts'ebetso ea li-epiphyseal ad1-adrenergic receptors inhibits AA-NAT cleavage mme e eketsa synthesin ea melatonin.

Ntle le gland ea pineal, tlhahiso ea melatonin e fumanoe liseleng tsa neuroendocrine tsa retina, lisele tsa enterochromaffin tsa seterata sa mokokotlo (lisele tsa EC), lisele tsa moea, thymus, adrenal gland, paraganglia, li-pancreas, le mefuta e meng ea lisele tse amanang le sisteme ea neuroendocrine. Lisele tse tšoeu tsa mali, liplatelete, endotheliocytes, lisele tsa cortex ea meno le lisele tse ling tseo e seng tsa endocrine le tsona li khona ho hlahisa melatonin. Mohloli o ka sehloohong oa ho potoloha ha melatonin ke tšoelesa ea phaene. Methapo ea secattion ea melatonin, e tsamaellanang le morethetho oa lefifi-khanya, ke tšobotsi feela ea tšoelesa ea pineal le retina.

Litholoana tsa 'mele tsa melatonin li kenella lipakeng le ka li-receptor tsa nyutlelie. Ho motho

lekholo la lilemo le fumane mefuta e 'meli ea li-receptor tsa melatonin: MT1 (MTNR1A) le MT2 (MTNR1B). Li-receptor tsa MT2 li fumanoa ka har'a retina, likarolo tse fapaneng tsa boko, 'me ho lumeloa hore ke ka tsona moo melapo ea liserekisi e thehiloeng. Ts'ebetso e ka sehloohong ea melatonin ke ho hokahanya mekhoa ea 'mele le ea metabolic ka litekanyo tsa letsatsi le letsatsi tsa 5, 6. Haholo-holo, secretion ea melatonin e ama methapo ea methapo e amanang le pelo le boits'ireletso ba mmele le tsamaiso ea methapo ea kutlo.

Matla a melatonin ho insulin secretion le glucose homeostasis

Ho sa bonahaleng hantle ha mesifa ea circadian ea secretion ea melatonin le insulin ho amana le phapang e teng mesebetsing ea tlhaho ea lihormone tsena. Ho fapana le melatonin, boemo bo tlase ba insulin ho batho bo bonoa bosiu, hobane ts'ebetso ea mantlha ea insulin - taolo ea metabolism maemong a morao-rao a lijo, ha ea lokela ho bonoa bosiu. Ho ile ha bontšoa hore tlolo ea tumellano e tloaelehileng pakeng tsa lijo le nako ea letsatsi le phetoho ea lijo tse tloaelehileng ka lihora tse 12 e tsamaisana le keketseho ea tlhahiso ea insulin ho baithaopi. Melatonin e tiisa khokahano ea lits'ebetso tsa metabolic le nako ea bosiu, i.e. nako e hlophisitsoeng ke motho bakeng sa ho itima lijo, hape e ka ba le phello e thibelang secretion ea insulin.

Taba ea polelo ea li-receptor tsa MT-1 le MT-2 melatonin lihlekehlekeng tsa pancreatic ka likhoto le litoeba li se li thehiloe. Lihlekehlekeng tsa batho, MT1 le, ho isa tekanyong e nyane, ho hlahisoa li-receptor tsa MT2 12, 13. Polelo ea M ^ receptors e tšoaea haholo-holo li-cell 11, 12, li-receptor tsa MT2 li fumanoa li-p-cell 11, 13, 14. vitro e bonts'a phello ea inhibitory ea melatonin ho secretion ea insulin liseleng tsa p, lisele tsa "insulinoma" tsa lisele (MIN-6), le likhoto (INS-1). Le ha ho le joalo, sebopeng se akaretsang, phello ea melatonin e kanna ea se be e makatsang. Melatonin e bontšitsoe ho matlafatsa secretion ea glucagon ka bobeli le insulin lihlekehlekeng tsa batho tse entsoeng ka oli. Ho tlalehiloe hore ha ho na phello ea melatonin ho secretion ea insulin li-islets of ob / ob mice (mohlala oa botenya) le mofuta oa lefu la tsoekere la mofuta oa 2 (lefu la tsoekere la 2). Botebo ba phello ea melatonin ho hlakile hore bo hlalosoa ka mekhoa e mengata e bonts'ang eo litlamorao tsa eona li arohaneng. Matla a inhibitory a melatonin tlhahiso ea insulin a tsamaisana le thibelo ea methapo e its'epahalletseng ea cAMP le cGMP, mme ts'usumetso e susumetsang e pakeng tsa 0 (d) -protein, phospholipase C le IP.

Liphetoho ho insulin secretion le glucose homeostasis li fumanoe liphoofolong tse nang le gland e tlositsoeng. Ho ile ha bontšoa hore pinealectomy ka har'a likhoto e lebisa ho hanyetsaneng ha insulin, ho kenella ha gluconeogeneis le keketseho ea glycemia bosiu. Ho eketsa secretion ea tsoekere ka matla le tsoekere

Lefu la tsoekere. 2013, (2): 11-16

keketseho ea bophahamo ba lithapo tsa eona e fumanoe liseleng tsa likhoto tse tlotsitsoeng ka har'a pinealectomy. Ho tlosoa ha tšoelesa ea pineal ka har'a likhoto ka mohlala oa T2DM (OLETF line) ho lebisa ho hyperinsulinemia le ho bokelloa ha triglycerides ka har'a sebete. Ho 'nile ha fanoa ka maikutlo a hore matatalin melatonin e ka hlophisa methapo ea methapo ea matla metabolism nakong ea bokhachane. Ho bana ba litoeba tse fuoeng ke pinealectomy, ho fokotseha ha sechetion ea tsoekere ka tsoekere, ho hanyetsoa ha insulin le, ka lebaka leo, ho ts'enngoa ha mamello ea glucose qetellong ea nako ea motšehare ho ile ha senoloa.

Ho bakuli ba nang le khatello ea mali ea methapo, ho fokotseha ha secretion ea melatonin bosiu ho amahanngoa le ho eketseha ha litekanyetso tsa insulin le index ea ho hanyetsa insulin.

Ka hona, ho bonahala eka melatonin e kenya letsoho ho theheng mokhoa o nepahetseng ka ho fetisisa oa metabolism ea matla maemong a secretion e tlase le maikutlo a phahameng a insulin bosiu.

Melatonin receptor gene polymorphism le kotsi ea lefu la tsoekere

Liphetho tsa lipatlisiso tsa liphatsa tsa lefutso tsa 'mele li bontšitse kamano pakeng tsa mefuta e fapaneng ea polymorphic ea melatonin receptor genes le nts'etsopele ea lefu la tsoekere la mofuta oa 2. Mefuta e 'meli e fapaneng ea polotorphism e le' ngoe ea mofuta oa MT2 (MTYB.1B): gb1387153 le gb10830963 li amana le glycemia e potlakileng, seculin le insulin le T2DM libakeng tsa Europe. Ho ile ha thehoa hore ho ba teng ha T allele ea locus GB 13 8 715 3 ho amahanngoa le glucose e potlakileng ea plasma (B = 0.06 mmol / L) le kotsi ea ho ba le hyperglycemia kapa T2DM (0H = 1.2). Tlhahlobo ea liphuputso tse leshome tsa genome e pharaletseng e bonts'a hore ho ba teng ha mofuta o mong le o mong oa G allele oa gb10830963 locus ea mofuta oa MTYB.1B ho amana le keketseho ea ho itima lijo ha glycemia ka 0.07 mmol / L, hammoho le ho fokotseha ha tšebetso ea b-cell, e hakantsoeng ke index ea HOMA-B. Tlhahlobo ea meta ea lithuto tse 13 tse nang le moralo oa taolo ea linyeoe li bonts'a hore boteng ba G allele sebakeng sena bo eketsa menyetla ea ho ba le T2DM (0H = 1.09).

Kahoo, mofuta oa MTYB.1B o ka nkuoa e le sebaka se secha sa mofuta oa tlhaho ea lefutso ho T2DM. Bophahamo ba tšusumetso ea mofuta oa MTIV.1B o kotsing ea ho ba le lefu lena bo bonolo, leha ho le joalo, bo ka bapisoa haholo le phello ea mefuta e meng ea "diabetogenic". Tse amanang haholo le kotsi ea lefu la tsoekere ke mefuta ea liphatsa tsa lefutso, ho kenyelletsa le MTIV.1B le mefuta e meng e amanang le glucose e potlakileng: OSK, OKKYA, O6RS2 25, 26.

Liphetoho ho secretion ea melatonin ho lefu la tsoekere

Mathata a amanang le secretion ea melatonin a fumanoe botsofaling le mafu a 'maloa a batho, ho kenyelletsa le mathata a amanang le nako le mathata a ho feto-fetoha ha maikutlo ho sa foleng.

Lefu la tsoekere. 2013, (2): 11-16

stv, dementia, likhathatso tsa boroko, syndromes ea bohloko, neoplasms e bohloko. Liphetoho tse rarahaneng sephiring sa melatonin li tšoauoa ke lefu la tsoekere. Mefuteng ea T1DM liphoofolong, ho bonts'oa keketseho ea melatonin maling, hammoho le keketseho ea polelo ea taolo ea taolo AA-NAT ka pineal gland 17, 27, 28. le BMAL1. Ho kenngoa ha insulin ka mokhoa ona oa lefu la tsoekere ho thusa ho hlophisa boemo ba melatonin maling le polelo ea liphatsa tsa lefutso gland.

Liphetoho tse ling tsa tlhahiso ea melatonin li fumanoe T2DM. Ho Goto Kakizaki rats (mofuta oa liphatsa tsa lefutso tsa T2DM), ho fokotseha ha polelo ea insulin receptor le ts'ebetso ea AA-NAT gland ea phaene e fumanoe. Bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba na le melatonin e maling. Liphuputso tse entsoeng ka sampole ea mali ka hora li senotse ho theoha ho hoholo ha secattion ea melatonin bosiu ho banna ba nang le lefu la tsoekere la 2. Ho bakuli ba nang le metabolic syndrome, litlolo tsa secattion tsa melatonin li ile tsa pepesoa, li bonahatsoa ke ho se be teng ha maemo a phahameng a mmele ho extretion ea metabolite ea melatonin 6-hydroxymelatonin sulfate (6-COMT) ka moroto bosiu. Bangoli ba bang, ka lehlakoreng le leng, ba senoletse hyperexcretion ea 6-COMT ho bakuli ba nang le metabolic syndrome. Karolelano ea melatonin / insulin ho plasma ea mali e nkuoeng ka hora ea 3 bosiu ho bakuli ba nang le metabolic syndrome e fokotsehile. Phapang bosiu le motšeareng ea melatonin e ne e amana hantle le glycemia ea ho itima lijo.

Ha ho tsejoehale ka liphetoho tse hlahisoang ke melatonin ho tsoekere ea lefu la tsoekere. Ho ile ha bontšoa hore ho likhoto tse nang le lefu la tsoekere la streptozotocin, boemo ba melatonin le ts'ebetso ea AA-NAT ho retina ea fokotseha, mme tsamaiso ea insulin e felisa likhathatso tsena. Liphetoho mabapi le motsoako oa melatonin ho retina ho lefu la tsoekere la tsoekere ha li e-so ithutoe. Ts'oaetso ea plasma melatonin ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le lefu la tsoekere le amanang le tsoekere e ne e le tlase haholo ho feta ho bakuli ntle le phepelo ena.

Kahoo, mefuta ea mantlha ea lefu la tsoekere e tšoauoa ka liphetoho tse fapaneng maemong a sephiri a melatonin ka har'a pineal gland le pokellong ea melatonin maling. Mefuteng ka bobeli ea lefu la tsoekere, kamano e sa lumellaneng e fumanoa pakeng tsa tlhahiso ea insulin le melatonin, e fanang ka maikutlo a ho ba teng likamanong tsa phetoho lipakeng tsa lihormone tsena.

Monyetla oa ts'ebeliso ea melatonin ho lefu la tsoekere

Kameho ea melatonin kholisong ea lefu la tsoekere la mofuta oa 1 e ithutile liteko. Melatonin e bontšitsoe ho eketsa ho eketseha ha bongata ba lisele tsa b le lisele tsa insulin ea mali ho litoeba tse nang le lefu la tsoekere la streptozotocin. Ntle le ho hlohlelletsa keketseho ea lisele tsa p, melatonin e thibela tšebetso ea tsona ea boea hape e boetse e tsosa sebopeho se secha

lihlekehleke tse tsoang ductal epithelium ea manyeme. Mohlaleng oa lefu la tsoekere mellitus e hlahisitsoeng ke streptozotocin ka likhoto nakong ea neonatal, melatonin ha e ame secretion ea insulin, empa e ile ea eketsa sensulin ea insulin le ho fokotsa glycemia. Matla a sireletsang a melatonin liseleng tsa b a ka 'na a bakoa, bonyane ka karolo, ho litlamorao tsa antioxidant le immunomodulatory. Ho netefalitsoe hore ho liphoofolo tse nang le lefu la tsoekere, melatonin e na le phello e ikhethang ea antioxidant mme e thusa ho khutlisetsa tekano e senyehileng ea li-antioxidants. Matla a thibelo ea melatonin ho li-lymphocyte tsa Th1 a imena habeli nako ea bophelo ea lihlekehleke tse fetisitsoeng ho litoeba tsa NOD.

Ts'ebeliso ea melatonin mohlaleng oa T2DM le metabolic syndrome (likhoto tsa Zucker) e ne e tsamaisana le ho fokotseha ha glycemia ea ho itima lijo, glycated hemoglobin (HbA1c). Ntle le moo, melatonin e theola maemo a leptin le litekanyetso tse eketsehileng tsa adiponectin. Lintlha tsena li fana ka maikutlo a hore melatonin e na le phello e molemo mosebetsing oa lithane tsa adipose, ho ruruha ho sa feleng, ho kenella ha insulin, carbohydrate le metabolism ea mafura 40, 41. Melatonin e thusa ho fokotsa boima ba 'mele mefuteng ea liphoofolo ea botenya. Ho latela liphuputso tse sa sebetseng, ho nka melatonin ho bakuli ba nang le metabolic syndrome ho tsamaisana le ho fokotseha ha khatello ea mali, matšoao a khatello ea oxidative, HOMA-IR le cholesterol. Tsamaiso ea melatonin ea nako e telele bakeng sa ho phekola ho hloka boroko ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 ha ea ka ea ama boemo ba insulin le C-peptide mme e ne e tsamaisana le ho fokotseha ho hoholo hoa HbA1c kamora likhoeli tse 5. kalafo.

Ho na le bopaki ba phello ea melatonin mabapi le nts'etsopele ea methapo ea pelo ea lefu la tsoekere. Melatonin e thibela ts'ebetso ea ts'ebetso ea lipid peroxidation lits'ebetsong tsa retina 45, 46, e ntlafatsa thepa ea elektroniki le ho fokotsa tlhahiso ea vascular endothelial grow factor (VEGF) ho retina tlasa hyperglycemia. Tsamaiso ea melatonin ho likhoto tse nang le lefu la tsoekere la streptozotocin e thibela kholo ea tlhahiso ea moroto ea albin 47, 48. Litsong tsa liphoofolo tse nang le lefu la tsoekere, melatonin e fokotsa khatello ea oxidative mme e thibela ho kopanngoa ha mabaka a fibrogenic: TGF-r, fibronectin. Tlas'a maemo a khatello ea maikutlo le ho ruruha, li-hormone li na le tšusumetso ho endothelium. Melatonin e khutlisetsa ho fokotseha ha moea ho ea ho endothelium, e holofetseng ho hyperglycemia. Matla a antioxidant a melatonin mokokotlong oa masapo a tsamaea le keketseho ea lipalo tsa lisele tsa endothelial progenitor tse tsamaeang le likhoto tse nang le lefu la tsoekere la streptozotocin. Lintlha tsena li khahla ntle ho pelaelo, hobane lefu la tsoekere le tsebahala ka ho bokella lisele tsena ho tsoa mokhatlong oa masapo.

Ho bakuli ba nang le lefu la tsoekere la mofuta oa 1, melatonin e eketsa tekanyo ea phokotso ea bosiu bosiu khatello ea mali ea diastolic. Litlamorao tsa morao-rao li ka ba le boleng bo amohelehang ho diabetesiconomonomic neuropathy e amanang le ho fokotseha ha tekanyo ea ho fokotseha hoa mmele ho khatello ea mali bosiu.

Lintlha tse hlahisitsoeng li bonts'a karolo ea bohlokoa ea melatonin ho taolo ea lithato tsa sephiri tsa secretion

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insulin le glucose homeostasis. Bakeng sa lefu la tsoekere, litlolo tsa ho potoloha ha melatonin ka har'a tšoelesa ea pineal le boteng ba melatonin maling ke tšobotsi. Lintlha tsa liteko li fana ka maikutlo a hore melatonin e ka fokotsa ho se sebetse hantle ha sele, ea lieha nts'etsopele ea lefu la tsoekere le mathata a lona. Karolo ea pathophysiological ea likhathatso ho secretion ea melatonin ho lefu la tsoekere le monyetla oa ts'ebeliso ea bongaka ba li-hormone tsena li lokeloa ke lipatlisiso tse ling.

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Konenkov Vladimir Iosifovich Klimontov Vadim Valerievich

Michurina Svetlana Viktorovna Prudnikova Marina Alekseevna Ishchenko Irina Yuryevna

Setsebi sa RAMS, MD, moprofesa, motsamaisi, Setsi sa Patlisiso sa FSBI sa Likolo tsa Bongaka le Tlhahlobo, Novosibirsk

MD, Hlooho Laborator of Endocrinology, FSBI Research Institute of Clinical and Experimental Lymphology, Novosibirsk E-mail: [email protected]

Ngaka ea Bongaka, Moprofesa, Ngaka ea Saense Laborator of Functional Morphology ea Lymphatic System, FSBI Patlisiso Setsi sa Clinical le liteko tsa Lymphology, Novosibirsk Laborator of Endocrinology, Setsi sa Patlisiso sa FSBI sa Tleliniki ea Tlhahlobo le Tlhahlobo, Novosibirsk

Ph.D., Mofuputsi ea Phahameng lilaboratori ea morphology e sebetsang ea tsamaiso ea lisele,

Setsi sa Patlisiso sa Tleliniki le Tlhahlobo ea Bohloeki, Novosibirsk