Mokhoa oa ho sebelisa lithethefatsi Neyrolipon?

Parenteral, kahare ho 300 le 600 mg: lefu la tsoekere le joala.

Kahare ea 12 le 25 mg: sebete se mafura, cirrhosis, hepatitis e sa foleng, hepatitis A, tahi (ho kenyeletsa letsoai la litšepe tse boima), chefo e nang le toadstool, hyperlipidemia (ho kenyelletsa le nts'etsopele ea coronary atherosulinosis - kalafo le thibelo )

Litlamorao

Ho tsoa ho tšilo ea lijo: ha ho nkuoa ka molomo - ho nyekeloa, ho hlatsa, bohloko ba ka mpeng, lets'ollo.

Litla-morao: Ho na le lekhopho la letlalo, ho hlohlona, ​​urticaria, ho thothomela ha anaphylactic.

Tse ling: hlooho e opang, "metabolism e senyehileng ea" glucose metabolism "e nang le ts'ebetso e potlakileng ea iv )

Capsule Neurolipon (Neurolipon)

Litaelo bakeng sa ts'ebeliso ea moriana oa bongaka

• Matšoao a ho sebelisoa
• Fomu ea tokollo
• Pharmacodynamics ea lithethefatsi
• Pharmacokinetics ea lithethefatsi
• Sebelisa nakong ea bokhachane
• Contraindication
• Litlamorao
• Tekanyetso le tsamaiso
• Bongata
• Ho sebelisana le lithethefatsi tse ling
• Litlhoko tsa ts'ebeliso
• Maemo a polokelo
• Letsatsi la ho felloa ke nako

Tlhophiso ea Nosological (ICD-10)

Tekanyetso le tsamaiso

Ho / ka. Batho ba baholo ka tekanyetso ea 600 mg / ka letsatsi. Kena butle butle - ha ho na ho feta 50 mg / min ea thioctic acid (1.7 ml ea tharollo ea infusion).

Setlhare se lokela ho fanoa ka ho kenngoa ka tharollo ea 0,9% sodium chloride hang ka letsatsi (600 mg ea moriana o kopantsoe le 50-250 ml ea tharollo ea chloride ea 0,9% sodium). Maemong a boima, ho fihlela 1200 mg e ka tsamaisoa. Litharollo tsa infusion li lokela ho sireletsoa leseli ka ho li koahela ka lithebe tse bobebe.

Nako ea kalafo e tsoa ho libeke tse peli ho isa ho tse 'ne. Kamora moo, ba fetoha pheko ea tlhokomelo le mefuta ea litekanyetso tsa thioctic acid bakeng sa tsamaiso ea molomo ka tekanyetso ea 300-600 mg / ka letsatsi bakeng sa likhoeli tse 1-3. Ho kopanya phello ea kalafo, ho khothalletsoa hore thupelo ea kalafo le lithethefatsi Neyrolipon e etsoe habeli ka selemo.

Ho sebetsa hantle le polokeho ea lithethefatsi ho bana ha li e-so theoleloe.

Fomu ea tokollo

Nahanela tharollo ea infusion, 30 mg / ml. Ka li-ampoules tsa khalase tse sootho, ka selikalikoe sa khefu kapa ntlha ea khefu, 10 kapa 20 ml.

5 kapa 10 amp. mmoho le mokotla oa filimi e ntšo ea PE kapa ka ntle ho eona ka pakete ea likarete tse nang le likamore tse silafetseng.

5 amp. ho blouse ea PVC filimi. 1 kapa 2 bl. ka li-ampoules hammoho le mokotla oa filimi ea PE e ntšo kapa ntle le eona ka pakete ea karete.

Moetsi

PJSC Farmak. 04080, Ukraine, Kiev, st. Frunze, 63.

Tel./fax: (8-10-38-044) 417-10-55, 417-60-49.

Mokhatlo o amohela likopo tse tsoang ho bareki: ofisi ea boemeli ea Farmak JSC ea sechaba sa Russia: 121357, Moscow, ul. Tebello ea Kutuzovsky, 65.

Mohala: (495) 440-07-58, (495) 440-34-45.

Contraindication

Hypersensitivity ho likarolo tsa moriana.

Boimana, nako ea ho anyesa (boiphihlelo ka moriana ha o lekane).

Bana ba ka tlase ho lilemo tse 18 (ho sebetsa hantle le polokeho ea tšebeliso ha ba e-so theoe).

Pheko e 'ngoe ea tšebeliso ea Neurolipon ka sebopeho sa li-capsules ke lefutso la lefutso la tlhaho, bofokoli ba lactase kapa malabsorption ea glucose-galactose.

Mofumahali

Karolo e sebetsang ea Neyrolipon - thioctic acid - e entsoe ka ho toba 'meleng mme e sebetsa e le coenzyme ho decidboxylation ea oxidative ea α-ketonic acid. Karolo ea bohlokoa e bapaloa ke thioctic acid ho metabolism ea matla ea lisele. Ka mofuta oa lipoamide, asiti e sebetsa e le cofactor ea bohlokoa ea li-enzyme tse ngata, e leng motsoako oa li-acarboxylation tsa α-keto acid ea potoloho ea Krebs.

Neyrolipon e na le thepa ea antitoxic le antioxidant, ho feta moo, thioctic acid e ka khutlisa li-antioxidants, mohlala, ho lefu la tsoekere la mellitus, e fokotsa ho hanyetsa insulin le ho liehisa nts'etsopele ea peripheral neuropathy.

Thioctic acid e thusa ho fokotsa glucose ea plasma le ho bokella glycogen sebeteng. E ama metabolism ea cholesterol, e nka karolo taolong ea metabolism ea mafura le lik'habohaedreite, e ntlafatsa ts'ebetso ea sebete ka lebaka la ts'ebetso ea hepatoprotective, antioxidant le detoxification.

Mofumahali

Litšobotsi tsa Pharmacokinetic ho latela mokhoa oa kopo:

• Tsamaiso ea molomo: ho amoheloa hoa mpa ho etsahala ka mpeng ea mpa (ka mpeng) ka potlako le ka botlalo, ha ho kenella ka Neurolipon ka lijo, ho amoheloa hoa fokotsoa. Bioavailability e tsoa ho 30 ho isa ho 60%, ntho ena e tšeloa metsoako pele e kenella ho potoloha ha tšebetso ha e feta leboteng la phepelo ea mpa le sebete (phello ea pele-pele). Nako ea ho fihlela khatello e phahameng (T_max) lekana le 4 μg / ml ke metsotso e ka bang 30. Metabolism ka har'a sebete e hlaha ka ho oxidation ea liketane tse lehlakoreng le conjugation. Thioctic asiti e epolloa ka har'a moroto ka liphio: ka mokhoa oa metabolites - 80-90%, e sa fetoheng - palo e nyane. T_1/2 (halofo ea bophelo) ke metsotso e 25,
• Tsamaiso ea batsoali: bioavailability ke

30%, metabolism e ba teng ka har'a sebete ka oxidation ea liketane tsa mahlakoreng le conjugation. T_1/2 - Metsotso e 20-50, lengolo le felletseng ke

694 ml / min, bophahamo ba phepelo ke lilithara tse 12,7. Kamora ente e le 'ngoe ea thioctic acid e kenang kahare, phello ea eona ke liphio ka lihora tse 3-6 tsa pele ho isa ho 93-97% ka sebopeho sa ntho e sa fetoheng kapa tse tsoang teng.

Litaelo tsa ho sebelisa Neyrolipon: mokhoa le litekanyetso

Neuroleipone e nang le sebopeho sa capsule e nooa ka molomo ka mpeng e se nang letho (halofo ea hora pele ho lijo), ntle le ho hlafuna le ho noa ka metsi a manyane kapa mokelikeli o mong o sa nkheng lehlakore.

Tekanyetso e khothalelitsoeng: 300-600 mg hang ka letsatsi. Bakeng sa kalafo ea "polyneuropathy" ea lefu la tsoekere qalong, tsamaiso ea botsoali ea thioctic acid e hlokahala.

Ngaka e beha qeto ea hore na nako ea phekolo e tla nka nako e kae.

Nahanela tharollo ea infusion

Tharollo e lokiselitsoeng ho tsoa ho "Neyrolipon" e kenang e tsamaisoa ka ho kenella butle-butle ka qoqothong (≤ 50 mg thioctic acid ka motsotso).

Tekanyetso e khothalletsoang: 600 mg hang ka letsatsi, maemong a boima, ho fihlela 1200 mg e lumelloa.

Ho lokisa tharollo ea infusion, tharollo ea Na9l ea 0.9% e sebelisoa ka bongata ba 50-250 ml ka 600 mg ea thioctic acid.

Nako ea karolelano ea phekolo ke libeke tse 2 - 4, kamora moo ba fetohelang kalafo ea kalafo ka thioctic acid ka mokhoa oa litokisetso tsa molomo (tekanyetso ea 300-600 mg ka letsatsi) bakeng sa likhoeli tse 1-3.

Bakeng sa ho kopanya phello ea Neyrolipona, ho khothalletsoa ho etsa lithuto tse phetoang hangata le makhetlo a 2 ka selemo.

Bongata

Matšoao a ho ata ha thioctic acid ha a tšoaroa ka hlooho a ka tšoaroa ke hlooho, ho nyekeloa ke pelo, ho hlatsa, ho tsitsinyeha ha maikutlo, ho ferekana ho matla tekong ea motheo ea acid le lactic acidosis, hypoglycemic coma, "methapo e kholo ea mali" ea methapo ho fihlela lefung.

Ho phekola boemo, o lokela ho emisa hang hang ho sebelisa lithethefatsi, ho hlatsoa mpa, ebe o nka mashala a ts'ebetso le ho etsa kalafo ea tlhokomelo.

Matšoao a bosholu ba thioctic acid ka tsamaiso ea batsoali ha a tsejoe.

Haeba u belaella ho fetella kapa ho hlaha hoa litla-morao tse mpe, o lokela ho emisa infusion, ka hona, ntle le ho tlosa nale ena ea ente, butle-butle kenya 0.9% isotonic NaCl tharollo ka sistimi. Lithethefatsi ha li na antiidote; ho khothalletsoa kalafo ea matšoao.

Litaelo tse khethehileng

Litharollo tsa infusion tse nang le thioctic acid li lokela ho sireletsoa leseli ka ho koahela lijana tse nang le lithebe tse bobebe.

Phekolo ea bakuli ba nang le lefu la tsoekere, ho hlokahala tlhahlobo ea tsoekere ea mali maemong a mang, maemong a mang, haeba ho hlokahala, phetoho ea li-ejenti tsa hypoglycemic ho thibela nts'etsopele ea hypoglycemia.

Nakong ea kalafo le Neurolipone, motho o lokela ho hana ho se noe lino tse nang le joala, hobane ethanol e thibela ts'ebetso ea eona ea kalafo.

Ho sebelisana le lithethefatsi

• glucocorticosteroids: acid ea thioctic e ntlafatsa katleho ea bona khahlanong le ts'oaetso,
• cisplatin: ho fokotseha hoa matla a eona a amang kalafo ho boletsoe,
• Lithethefatsi tse nang le litšepe (tšepe, magnesium, calcium litokisetso): thioctic acid e tlama lira, ka hona, tsamaiso ea tsona e ts'oanang e lokela ho qojoa, ho bohlokoa ho boloka karohano lipakeng tsa tekanyetso ea bonyane lihora tse peli,
• "insulin" kapa "acid" e ka baka phello ea tsona,
• ethanol le metabolites tsa eona: li thibela ketso ea thioctic acid.

Tharollo ea infusion ea liforomo tsa Neyrolipon ha e qhibilihe ka tsela e rarahaneng le tsoekere, ka hona ha e lumellane le tharollo ea Ringer, tsoekere le fructose. Hape ha e lumellane le tharollo ea metsoako e sebetsanang le lihlopha tsa SH-kapa ho senya lithapo le litokisetso tse nang le ethanol.

Litlhahlobo mabapi le Neyrolipone

Litlhahlobo mabapi le neuroleepone li pheha khang. Bakeng sa bakuli ba bang, moriana ona ha o tšoanelehe, ho thoe ke pheko e sa sebetseng e nyenyefatsang matšoao a lefu hanyane mme e baka karohano e mpe.

Litlhahlobo tse ling tse 'maloa, neurolypone e tsejoa e le lithethefatsi tsa khetho ka lebaka la ho se be le karabelo e mpe le ts'ebetso e phahameng.

Theko ea Neyrolipon libakeng tsa meriana

Theko e lekantsoeng ea NeroLipone:

• tsepamisa maikutlo bakeng sa ho hlophisoa ha tharollo ea infusion (li-ampoules tse 5 ka paketeng ea likarete): li-ampoules tsa 10 ml - li-ruble tse 170, ka li-ruble tse 20 ml - li-ruble tse 360,
• li-capsules (li-pcs tse 10. ka har'a lithutsoana, lithutsoana tse 3 ka pakete ea likarete) - li-ruble tse 250.

Thuto: Univesithi ea bongaka ea pele ea bongaka ea Moscow State e reheletsoeng ka I.M. Sechenov, ngaka e ikhethang "General Medicine".

Tlhahisoleseling mabapi le sethethefatsi e akaretsoa ka kakaretso, e fanoa molemong oa tlhahisoleseling mme ha e nke sebaka sa litaelo tsa semmuso. Ho ikoetlisa ho kotsi bophelong!

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Tharollo ea infusion e fanoa ka methapo ho batho ba baholo ka lethal dose ea 600 mg ka letsatsi. E fanoa butle butle - eseng ho feta 50 mg ea thioctic acid (1.7 ml ea tharollo ea infusion) ka motsotso.

Setlhare se lokela ho fanoa ka ho kenngoa ka tharollo ea 0,9% sodium chloride nako e le ngoe ka letsatsi (600 mg ea moriana o kopantsoe le 50-250 ml ea tharollo ea chloride ea 0.9% sodium). Maemong a boima, ho fihlela 1200 mg e ka tsamaisoa. Litharollo tsa infusion li lokela ho sireletsoa leseli ka ho li koahela ka lithebe tse bobebe.

Nako ea kalafo e nka libeke tse peli ho isa ho tse 'ne. Kamora moo, ba fetohela kalafo ea ho lokisa le Neyrolipon bakeng sa tsamaiso ea molomo (li-capsules) ka lethal dose ea 300-600 mg ka letsatsi bakeng sa likhoeli tse 1-3. Likhohlopo li nooa ka molomo ntle le ho hlafuna, li hlatsuoa ka metsi a fokolang, metsotso e 30 pele ho lijo (ka mpeng e se nang letho). Ho kopanya phello ea kalafo, ho khothalletsoa mokhoa oa phekolo makhetlo a mabeli ka selemo.

Nako ea kalafo e khethoa ke ngaka.

Ho sebetsa hantle le polokeho ea lithethefatsi ho bana ha li e-so theoleloe.

Ketso ea pharmacological

Thioctic acid, eo e leng karolo ea Neuroleipon, e entsoe 'meleng' me e sebetsa e le coenzyme ka har'a oxidative decarboxylation ea alpha keto acid, mme e bapala karolo ea bohlokoa ho metabolism ea matla ea sele. Ka sebopeho sa amide (lipoamide) ke cofactor ea bohlokoa ea li-enzyme tse ngata tse ferekanyang decarboxylation ea Krebs alpha-keto acids. Thioctic acid e na le litlamorao le li-antioxidant, e boetse e khona ho khutlisetsa li-antioxidants tse ling, tse kang lefu la tsoekere. Ho bakuli ba nang le lefu la tsoekere, thioctic acid e fokotsa ho hanyetsa insulin mme e thibela nts'etsopele ea peropheral neuropathy.

E thusa ho fokotsa bongata ba glucose maling a plasma le ho bokellana ha glycogen bokong. Thioctic acid e ama metabolism ea cholesterol, e nka karolo taolong ea metabolism ea lipid le carbohydrate, e ntlafatsa ts'ebetso ea sebete (ka lebaka la hepatoprotective, antioxidant, detoxification).

Tšebelisano

E ntlafatsa phello e khahlanong le ho ruruha ea lithethefatsi tsa glucocorticosteroid.

Ka tsamaiso e tšoanang ea thioctic acid le sisplatin, ho fokotseha ho matlafatsang katleho ea cosplatin.

Thioctic acid e tlama tšepe, ka hona, ha ea lokela ho beoa ka nako e ts'oanang le lithethefatsi tse nang le tšepe (mohlala, tšepe, magnesium, calcium) - karohano lipakeng tsa litekanyetso e lokela ho ba bonyane lihora tse 2.

Ka tšebeliso e tšoanang ea thioctic acid le lithethefatsi tsa insulin kapa tsa molomo, phello ea bona e ka ntlafatsoa.

Tai le methapo ea eona ea methapo e theola matla a neuroleipone.