Avelox® (400 mg) Moxifloxacin

Kea le lumelisa!

Avelox e ne e laetsoe ke ngaka ea mafu a basali, ka hona banna ba molemo ho feta tsohle tse ngoliloeng ka tlase, ho molemo hore ba se ke ba bala.

Lilemong tse peli tse fetileng, ke ne ke se ke ngotse litlhahlobo ka "Ke ts'oeroe hampe"ka hona ke abetsoe:

Ebe ke tlameha ho utloa bohloko: kalafo ha ea ka ea fana ka litholoana hanghang. Mme lekhetlong lena e ne e batla e tšoana.

Ha ke tsebe hore na ho etsahalang ka 'mele oa ka, empa bothata bo nang le smear e mpe ke lisele tse tšoeu tsa mali tse phahameng -

o ile a nketela hape selemong sena. Mme ho ne ho bonahala ho se letho le bohloko, ho na le ho ba le ho se utloane ho itseng feela, hoo hangata ho etsahalang maemong a joalo.

Ka kakaretso, ke moeti khafetsa ho gynecology: scan ninemanga makhetlo a mabeli ka selemo le tlhahlobo e tlamang ea ngaka ea gynecologist-endocrinologist. Taba ke hore tlhahlobo ea ka ea nako e telele ke hyperplasia ea endometrial.

Haufinyane tjena ke hlokometse hore ke endometrial hyperplasia e ka qholotsang leukocytes ka smear - hobane tsepamiso ea endometrium e lula e le teng ka popelong.

Ngaka e ile ea tsitlella hape ho etsa hysteroscopy, empa liteko "tse ntle" li hlokahala bakeng sa ts'ebetso ena. Ho etsa sena, ke ile ka fuoa likerese tsa pele, mme ha - ha ke etela ngaka hape, ke loants'oa lithibela-mafu.

Ngaka ea gynecologist e laetse likerese tsa Fluomizinum pele.

Empa kalafo ea bona, leha e ne e le monate, e sa ka ea ntlafatsa sephetho sa smear, - ho latela ngaka, o ile a mpefala le ho feta.

Joaloka ngaka ea mafu a basali, ha ke tsebe hore na o ne a tataisoa ke eng - ho hang ke ne ke sena ts'oaetso ka lebaka la ultrasound - o ile a fana ka motsoako o matla oa lithibela-mafu tsa moloko o mocha - Avelox.

Ho nkholisa hore "ka sebele o tla thusa hang-hang!", Ntle le moo, ho ile ha nkoalla lithethefatsi tse ling tse ngata tse ka thibelang ho hlaha ha dysbiosis le thrush.

Ka kakaretso, kalafo ea ka e ile ea batla e le penny!

Pele o nka avelox 'Na, joalo ka mehleng, ke bala litlhahlobo, ho tloha moo ho ileng ha hlaka hore mmele oa ka o sitoa ho fetisetsa Avelox, kaha ke na le mathata le senya la senya, le horehona ho bolelahoo e ka bang maloetse 'ohle aa thusa.

Kopo

Ke nkile tafole ea Avelox 1 ka letsatsi kamora ho ja, ke hlatsoitsoe ka metsi libeke tse peli.

Ke lekile ho se theole nako ea ho ja e le hore ho se be le mojaro o sa hlokahaleng 'meleng.

Matšoao

Mafu a tšoaetsanoang le a tšoaetsanoang ho batho ba baholo a bakoang ke likokoana-hloko tse anngoeng ke lithethefatsi: a hlobaetsang le lefu la sethoathoa, pneumonia e fumanehang sechabeng (ho kenyelletsa le a bakoang ke mathata a microorganism a nang le khatello e matla ea meriana e thibelang likokoana-hloko), ho ata ha bronchitis e sa foleng, tšoaetso e sa rarahaneng ea letlalo le lisele tse bonolo. Meaho (ho kenyeletsoa leoto la tsoekere le tšoaelitsoeng), tšoaetso e rarahaneng ea ka mpeng, ho kenyelletsa le tšoaetso ea polymicrobial li-abscesses tse kenang ka hare, mafu a sa rarahanang a ruruhang a litho tsa pelvic (ho kenyeletsa le salpingitis le endometritis).

Contraindication

moimana, ho nyekeloa ke letsoele (matsoele),
bana le bacha ba ka tlase ho lilemo tse 18,
hypersensitivity ho moxifloxacin le likarolo tse ling tsa lithethefatsi.

Litlamorao

Ho khaoloa ha karohano ea QT (hangata ho bakuli ba nang le hypokalemia e kopaneng, ka linako tse ling ho bakuli ba bang), tachycardia le vasodilation (ho fifala ha sefahleho), hypotension ea methapo, khatello ea methapo ea methapo, ho nyekeloa, li-tricyarrhythmias, ho kenyelletsa (extrasystole) (ventricular pirouette mofuta arrhythmia) kapa ho tšoaroa ha pelo ka ho khetheha ho batho ba nang le maemo a rerileng ho hlophisoa, joalo ka bradycardia ea bohlokoa, ischemia e hlobaetsang le ho fokola ha moea, ho kenyelletsa le ho hema Math, ho nyekeloa, ho hlatsa, ho opeloa ke mpa, lets'ollo, ho ipolaisa tlala, ho sokela, dyspepsia, flatulence, gastroenteritis (ntle le gastroenteritis e ruruhileng), stomatitis, pseudomembranous colitis (maemong a sa tloaelehang a amanang le mathata a behang bophelo kotsing), jaundice, hepatitis (haholo cholestate ), ho ts'oaroa ke hlooho, ho opeloa ke hlooho, ho ferekana, ho ferekana, ho otsela, ho tsitsinyeha ha boroko, ho tšoenyeha, ts'ebetso e eketsehileng ea psychomotor, ts'ebelisano e senyehileng (ho kenyeletsa le likhathatso tsa gait ka lebaka la ho tsekela 'Na, maemong a sa tloaelehang haholo, ke lebisa ho tsoa likotsi ka lebaka la ho oa, haholo ho bakuli ba tsofetseng), ho ts'oaroa ka tšohanyetso ka lipontšo tse fapaneng tsa kliniki (ho kenyeletsa le bakuli ho ts'oaroa ke bokuli bo boholo mal, ho sitisoa ho tsepamisa maikutlo, mathata a puo, amnesia, khatello ea maikutlo (maemong a sa tloaelehang, boitšoaro bo nang le mokhoa oa ho intša kotsi bo ka etsahala), hallucinations, psychotic reaction (Ka mokhoa o bonts'itsoeng o bontša ka boits'oaro bo nang le tloaelo ea ho intša kotsi), mathata a ho latsoa, ​​ho ferekana hoa pono (ho fifala, ho fokotseha hoa maqhubu a pono, diplopia, haholoholo hammoho le ho tsekela le pherekano), tinnitus, tlolo ea monko, ho kenyelletsa le anosmia, tahlehelo ea maikutlo a tatso, anemia, leukopenia (ho kenyeletsa neutropenia), thrombosis cytopenia, thrombocytosis, nako e telele ea prothrombin 'me e fokotsehile INR, arthralgia, myalgia, tendonitis, molumo oa lentsoe oa mesifa le maratsoana, ho phatloha ha tendon, "netefatso ea semmuso," vaginitis, ho fokola hoa mmele (ho bakoang ke lets'ollo kapa ho fokotseha hoa mokelikeli oa metsi ", ho hloleha ha renal, ho hloleha ha renal ka lebaka la ho se sebetse hantle ha renal. , e ka lebisang ho senyeha ha menoana (haholoholo ho bakuli ba tsofetseng ba nang le bothata ba ho hlaphoheloa renal), ho nyekeloa ke letlalo le leholo, mohlala, Stevens-Johnson kapa le chefo. lefu la epidermal necrolysis (le ka behang bophelo kotsing), urticaria, pruritus, rash, eosinophilia, anaphylactic / anaphylactoid reaction, angioedema, ho kenyelletsa le laryngeal edema (e ka 'nang ea beha bophelo kotsing), ho tsitsinyeha ha anaphylactic (ho kenyeletsa bophelo bo behang bophelo kotsing), malaise e akaretsang (ho kenyeletsoa matšoao a bophelo bo botle, ho se utloe bohloko ke bohloko le ho ruruha), ho ruruha.

Sebopeho

Ntho e sebetsang: moxifloxacin hydrochloride - 436.8 mg

Ponahalo

Matlapa, joalo ka ha u bona, a ntse a le maholo, empa ka lebaka la sebopeho sa bona se phahameng ba ile ba tahoa ka mokhoa o tloaelehileng.

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi ea 400 mg

Letlapa le leng le na le

akntho e sebetsang - moxifloxacin hydrochloride 436.8 mg,

(e lekanang le moxifloxacin 400.0 mg),

Baeti: lactose monohydrate, cellulose ea microcrystalline, sodium ea lipalesa, le magnesium stearate,

Ho hlophisoa ha khetla: iron oxide e khubelu, hypromellose, macrogol 4000, titanium dioxide.

Ho ne ho e-na le matlapa a bofubelu bo bofubelu bo kobehileng, a koahetsoeng ka bolelele ba limilimithara tse 17 le bophara ba limilimithara tse 7, 'me a le "M 400" ka lehlakoreng le leng.

Melemo ea pharmacological

Mofumahali

Suction le bioavailability

Ha moxifloxacin e nooa ka molomo, e kenella ka potlako 'me e batla e felile ka botlalo. Boaoavailability e felletseng e ka ba 91%.

Pharmacokinetics ea moxifloxacin ha e nooa ka tekanyetso ea 50 ho isa ho 1200 mg hang, hammoho le 600 mg / letsatsi ka matsatsi a 10, e kahare. Mmuso oa tekano o fihlelloa nakong ea matsatsi a 3.

Kamora tekanyetso e le 'ngoe ea 400 mg ea moxifloxacin, khatello e phahameng (C max) maling e fihlella ka nako ea lihora tse 0.5-4 mme ke 3.1 mg / l. Litekanyetso tse phahameng ka ho fetisisa tsa plasma tse maemong a tsitsitseng (400 mg hang hang ka letsatsi) li ne li le 3.2 le 0,6 mg / L, ka ho latellana.

Ha u nka moxifloxacin ka lijo, ho na le keketseho e nyane nakong ea ho fihla Cmax (ka lihora tse 2) le phokotso e nyane ho Cmax (ka 16%), ha nako ea ho amoheloa e sa fetohe. Leha ho le joalo, lintlha tsena ha li na bohlokoa ba bongaka, kaha karolelano ea AUC / MIC e bolela esale pele mosebetsi oa antimicrobial oa li-quinolones. Ka hona, moriana o ka sebelisoa ho sa tsotelehe takatso ea lijo.

Moxifloxacin e tsamaisoa ka potlako haholo betheng ea motlakase. Ho na le sebaka se seholo tlasa AUC pharmacokinetic curve (AUCnorm = 6 kg * lihora / L) e nang le bophahamo bo lekanang ba ho tsamaisa (Vss) ea moxifloxacin e ka bang 2 L / kg. Pherekano e phahameng ea moxifloxacin mathetleng e phahame ho feta ho plasma. Lithutong tsa in vitro le tsa vivo boteng ba mahloriso ho tloha ho 0,02 ho isa ho 2ml / l, ho tlama ha moxifloxacin ho liprotheine ho ne ho batla ho le 45%, ho sa tsotelloe ke khatello ea meriana.

Moxifloxacin e amana haholo le plasma albin.

Ho na le tlhoro e phahameng ea mahloriso a mahala> 10xMIC ka lebaka la bonyata bo tlase.

Ho tsepamisa mohopolo o phahameng oa lithethefatsi, tse fetang tse leng ho plasma, ho entsoe ka liseleng tsa matšoafo (mokelikeli oa li-epithelial, li-macrophages tsa alveolar, lisele tsa likokoana-hloko), lijong le polyps, motheong oa ho ruruha. Ka mathe, mokelikeli o kopaneng (intermuscular and subcutaneous), khatello e phahameng ea lithethefatsi e le mahala e ikemiselitsoe.

Ntle le moo, litekanyetso tse phahameng tsa lithethefatsi li khethoa kahare ho litho tsa mpa ea mpa le mokelikeli oa litho tsa botona le botšehali.

Kamora tekanyetso e le 'ngoe ea moxifloxacin 400 mg, litselaneng ka bobeli tsa tsamaiso, ho ile ha shejoa lintho tse ngata haholo ha li bapisoa le khatello ea plasma liseleng tse fapaneng tsa sepheo.

Kamora ho fetisa mohato oa bobeli oa biotransformation, moxifloxacin e nts'oa 'mele ka liphio le pampitšana ea gastrointestinal (GIT) e sa fetoheng le ka sebopeho sa metsoako e sa sebetseng ea Sfofo (M1) le glucuronides (M2). Li-metabolites tsena li sebetsa 'meleng oa motho feela' me ha li na mesebetsi ea ho loants'oa likokoana-hloko. Phuputso e entsoeng mabapi le tšebelisano ea metabolic pharmacokinetic le lithethefatsi tse ling e bontšitse hore moxifloxacin ha e ea biotransformed ke microsomal cytochrome P450 system.

Ho sa tsotelehe mokhoa oa ts'ebeliso, metabolite M1 le M2 li fumanoa ka plasma ea mali mokokotlong o tlase ho feta mokokotlo oa moxifloxacin o sa fetoheng.

Bophelo ba halofo ea lithethefatsi ho tsoa ho plasma ke lihora tse ka bang 12. Tlhahiso e akaretsang ea kamora ho nka tekanyetso ea 400 mg e tsoa ho 179 ho isa ho 246 ml / min. Ho hlakoloa ha molao hoo e ka bang 24-53 ml / min ho etsahala ka mokhoa o itseng oa ho kopanya lithethefatsi lipelong. Ts'ebeliso e kopaneng ea ranitidine le probenecid ha e ame ho hlakisoa ha moriana. Ho sa tsotelehe tsela ea tsamaiso, thepa e qalang moxifloxacin e batla e le 96-98% e kentsoeng ho metabolites ea mohato oa bobeli oa metabolism ntle le matšoao a metabolism ea oxidative.

Pharmacokinetics ka lihlopha tse fapaneng tsa bakuli

Phapang lipakeng tsa pharmacokinetics ea moxifloxacin ha e e-so thehoe.

Paul Phapang (33%) ho li-pharmacokinetics (AUC, Cmax) lipakeng tsa banna le basali li senotsoe. Phapang e senotsoeng ho AUC le Cmax e hlalositsoe ka phapang ea boima ba 'mele ho feta ka bong. Kahoo, ha li bohlokoa ka tliliniki.

Phapang e ka khonehang eaoncthnic e ile ea ithutoa Caucasoid, Majapane, Negroid le merabe e meng. Phapang ea bohlokoa ka ho khetheha ho pharmacokinetics ea moxifloxacin ha e e-so thehoe.

Pharmacokinetics ea moxifloxacin ho bana ha e e-so ithutoe.

Ha ho na liphetoho tse kholo ho pharmacokinetics ea moxifloxacin ho bakuli ba nang le ts'ebetso ea renal e sa sebetseng (ho kenyelletsa bakuli ba nang le tumello ea creatinine ea 1/100 le 1/1000 le 1/10 0000 le 1 / 1,000)

- Phetoho ea mahloriso a thromboplastin

- anaphylactic / anaphylactoid reaction, allergic / angioedema, ho kenyelletsa le laryngeal edema (e ka behang bophelo kotsing)

- lability ea maikutlo, khatello ea maikutlo (maemong a sa tloaelehang haholo, a ka bonoa ka boitšoaro bo nang le tšekamelo ea ho intša kotsi, joalo ka menahano ea ho ipolaea kapa liteko), lipono

- hyposthesia, tlolo ea monko, ho kenyelletsa le anosmia

- litoro tsa pathological, ts'ebelisano e senyehileng (ho kenyeletsa le ho senyeha gait, haholo ka lebaka la ho tsekela kapa vertigo (e lebisang ho tsoa likotsi, haholo ho bakuli ba tsofetseng maemong a sa tloaelehang), ho ts'oaroa ka lipontšo tse fapaneng tsa kliniki (ho kenyeletsoa le tse akaretsang), tlhokomelo e senyehileng, mathata a puo, amnesia

- peripheral neuropathy le polyneuropathy

- tinnitus, ho senyeha ha kutlo, ho kenyelletsa ho se utloe litsebeng (hangata ho fetoloa)

- ho akheha, khatello ea maikutlo, khatello e matla ea mali, tachyarrhythmias ea ventricular

- dysphagia, stomatitis, pseudomembranous colitis (e amanang le mathata a behang bophelo maemong a sa tloaelehang haholo), jaundice, hepatitis (haholo cholestatic)

- tendonitis, molumo o eketsehileng oa mesifa le mesifa ea mesifa, bofokoli ba mesifa

- mosebetsi o sa sebetseng oa renal, ho hloleha ha rems (ka lebaka la ho felloa ke metsi 'meleng, haholo-holo ho bakuli ba tsofetseng ba nang le bothata ba ho hlaphoheloa renal)

Sokolla foromo le sebopeho

Avelox e fumaneha ka mokhoa oa matlapa a koahetsoeng le tharollo ea infusion.

Motsoako o sebetsang ke moxifloxacin: Letlapeng le le leng le 250 ml ea tharollo - 400 mg.

Ba fumanang matlapa: lactose monohydrate, cellcose ea microcrystalline, sodium ea croscarmellose, magnesium stearate, hypromellose, oxide oxide, macrogol 4000, titanium dioxide.

Likarolo tse thusang tsa tharollo: 1M hydrochloric acid, sodium chloride, 2M sodium hydroxide solution, metsi bakeng sa ente.

Mofumahali

Moxifloxacin (lebitso la lik'hemik'hale - 8-methoxyfluoroquinolone) ke moemeli oa bactericidal antibacterial e pharaletseng. Tšusumetso ea eona ea bactericidal e bakoa ke taba ea hore ke ntho e thibelang libaktheria topoisomerases II le IV. Sena se baka pherekano mokhoeng oa ho ngola, ho lokisa le ho pheta-pheta DNA ea biosynthesis ea lisele tse likokoana-hloko, ka lebaka leo, e lebisang lefung la mora oa bobeli.

Metsotso e fokolang ea bactericidal ea moxifloxacin hangata e ka bapisoa le ho tsepamisa maikutlo ho honyenyane. Ts'ebetso ea antibacterial ea Avelox ha e khethoe ke mekhoa e etsang hore motho a se ke a hloa mekoalaba, penicillin, macrolides, aminoglycosides le cephalosporins. Phapang pakeng tsa lihlopha tsena tsa lithethefatsi tse thibelang antibacterial le moxifloxacin ha ea ka ea fumanoa. Mabaka a ho hanyetsa plasmid ha a so ngolisoe hajoale. Keketseho e akaretsang ea khanyetso e nyane haholo (10 -7 - 10 -10).

Ho hanyetsa Avelox ho fetoha ha nako e telele ho feta ka ho feto-fetoha ha mefuta e mengata.

Ho pepesetsoa khafetsa ho karolo e sebetsang ea Avelox ka har'a likhakanyo tse sa fihlelleng boleng ba bonyane ba inhibitory mahloriso (MIC), ho lebisa keketseho e nyane feela ea MIC.

Ho na le maemo a ho hanyetsa sefapano sa quinolones. Leha ho le joalo, likokoana-hloko tse ling tsa anaerobic le gram tse khahlano le li-quinolones tse ling li bonts'a kutloisiso ea moxifloxacin.

Ho fumanoe hore kenyelletso ea sehlopha sa methoxy sebakeng sa C8 moxifloxacin sebopeho sa limolek'hule se eketsa ts'ebetso ea eona mme e thibela ho etsoa ha mefuta e tsitsitseng ea libaktheria tse ntle tsa gram.

Ho eketsoa ha sehlopha sa libaesekele ho molek'hule e maemong a C7 ho thibela sebopeho sa mafolofolo a sebetsang le mochine oa ho hanyetsa fluoroquinolones.

In vitro moxifloxacin e sebetsa khahlano le libaktheria tse fapaneng tsa gram tse ntle le gram-negative, anaerobes, li-microorganism tse loantšang acid tse (acid e bitsoang Legionella spp.

Hona joale, ho tsejoa lithuto tse peli le baithaopi tseo ho tsona ho ileng ha ithutoa liphetoho kahara microflora ea ka mpeng ka mor'a ho ithuta ka moxifloxacin ka molomo. Li bonts'itse ho fokotseha hoa likhahla tsa Klebsiella spp., Escherichia coli, Enterococcus spp. Liphetoho tsena li ile tsa fetoloa libeke tse peli. Toxin ea Clostridiumntyile ha e so tsejoe.

In vitro moxifloxacin e bonts'a ts'ebetso e phahameng ea antibacterial khahlanong le likokoana-hloko tse latelang:

• Libaktheria tse nang le "gram": Gardnerella vaginalis, methicillin e amehang ea methapo ea methapo ea mafu a coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S.hominis, S. haemolyticus), Staphylococcus aureus (lits'oants'o tse bonts'ang kutloisiso ea methicillin), Streptococcus pneumoniae ho kenyeletsoa mefuta e hananang le penicillin, le mathata a hanyetsanang le meriana e thibelang likokoana-hloko ka makhetlo a mabeli. trimethoprim / sulfamethoxazole, penicillin (MIC ho feta 2 μg / ml), li-tetracyclines, li-cephalosporins tsa moloko oa bobeli (mohlala, cefuroxime), li-macrolides, Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus pharaportatidiaidzilidrate ya sedretia. , S. thermophilus, S. mutans, S. sa livarius, S. sanguinis, S. mitis), sehlopha sa Streptococcus milleri (S. intermedins, S. constellatus, S. anginosus),
• Baktheria ea gram-negative: Proteus vulgaris, Haemophilus parainfluenzae, Haemophilus influenzae (ho kenyelletsa le lintho tse amanang le mathata ebile li sa hlophise li-β-lactamases), Acinetobacter baumannii, Moraxella catarrhalis (ho kenyelletsa le mefuta e hlahisang 'me e sa hlahise β-lactamases, Bordella pneumonia, Bordella pneumonia
• likokoana-hloko tsa anaerobic: Propionibacterium spp., Fusobacterium spp., Prevotella spp, Porphyromonas spp.,
• likokoana-hloko tse kholo: Coxiella burnetii, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae.

Likokoana-hloko tse latelang li nahanela moxifloxacin ka mokhoa o hlakileng:

• Libaktheria tse nang le sebopeho se matla: Enterococcus faecium, Enterococcus avium, Enterococcus faecalis (e khethollang feela li-glamicin le vancomycin),
• baktheria e se nang gram: Providencia spp. (P. stuartii, P. rettgeri), Escherichia coli, Neisseria gonorrhoeae, Klebsiella oxetoca, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Proteus mirabilis, Enterobacter spp. (E. sakazakii, E. intermedius, E. aerogene), Enterobacter cloacae, Stenotrophomonas maltophilia, Burkholderia cepacia, Pseudomonas fluorescens, babuelli ba litaba ba Pantoea,
• likokoana-hloko tsa anaerobic: Clostridium spp., Peptostreptococcus spp., Bacteroides spp. (B. vulgaris, B. fragilis, B. sareis, B. distasonis, B. ovatus, B. thetaiotaomicron).

Likokoana-hloko tse latelang li bontša ho hanyetsa sethethefatsi:

• baktheria e ntle ea gram: Mefuta e thibelang methapo ea methapo ea methapo ea mafu a amanang le coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. Hominis, S. haemolyticus), ofloxacin / methicillin e thibelang mafu a Staphylococcus aureus,
• Baktheria ea gram-negative: Pseudomonas aeruginosa.

Ts'ebeliso ea Avelox ha e khothalletsoe kalafong ea tšoaetso e bakoang ke lits'oants'o tsa Staphylococcus aureus ka khanyetso e tiisitsoeng ea methicillin (MRSA). Maemong a tšoaetso e ka 'nang ea hlaha kapa e pakiloeng ke MRSA, kalafo e nang le lithethefatsi tse nepahetseng tsa antibacterial e lokela ho fanoa.

Bakeng sa mafu a itseng, ho hanyetsa ho fumanoeng ho ka ata ho fapana ka nako ho latela nako le sebaka sa bakuli. Ka lebaka lena, ha ho hlahlojoa maikutlo a khatello ea methapo, ho khothalletsoa ho ithuta tlhaiso-leseling mabapi le ho hanyetsa, haholo kalafo ea mafu a tšoaetsanoang a matla.

Haeba ho bakuli ba ntseng ba phekoloa sepetlele, boleng ba sebaka tlasa "pharmacokinetic curve" concentration - time "(AUC) / MIC₉₀ e feta 125, 'me litaba tsa moxifloxacin li ka holimo ho plasma ea mali (C_max) / MIC₉₀ e maemong a 8-10, hona ho bolela tlatsetso e ntle e ntlafalitsoeng le ntlafatso ea bongaka. Ka linako tse ling, matšoao ana a fetoha a fokolang (AUC / MIC₉₀ e feta 30-40).

Ha o nka sebopeho sa molomo oa Avelox: e nang le MIC e tloaelehileng₉₀ 0.125 mg / ml AUIC (sebaka se ka tlas'a khibitelo ea inhibitory, i.e. tekanyo ea AUC / MIC₉₀) e lekana le 279, le C_max/ MIC₉₀ - 23,6. Ka litekanyetso tsa MIC₉₀ 0.25 mg / ml le 0,5 mg / ml AUIC le C boleng_max/ MIC₉₀ ba ka tatellano ea ba 140 le 11.8 maemong a pele mme ba 70 le 5.9 ketsahalong ea bobeli.

Ka ho kenella kahare: ka MIC e tloaelehileng₉₀ 0.125 mg / ml AUIC ke 313 le C_max/ MIC₉₀ - 32,5. Ka litekanyetso tsa MIC₉₀ 0.25 mg / ml le 0,5 mg / ml AUIC le C boleng_max/ MIC₉₀ ka tatellano 156 le 16.2 nyeoeng ea pele mme 78 le 8.1 ketsahalong ea bobeli.

Mofumahali

Ha o kenya Avelox kahare, moxifloxacin e kenngoa ka lebelo le phahameng mme e batla e le ka botlalo. Bioavailability ea eona e felletseng e ka bang 91%. Ho netefalitsoe hore pharmacokinetics ea ntho ena e nang le lethal e le 'ngoe ka bongata ba 50-1200 mg, hammoho le tekanyetso ea Avelox ka tekanyetso ea letsatsi le letsatsi ea 600 mg bakeng sa matsatsi a 10, e mola. Mmuso oa tekano o thehiloe nakong ea matsatsi a 3.

Kamora tekanyetso e le 'ngoe ea 400 mg ea Avelox, khatello e phahameng maling e fihlella ka lihora tse 0.5-4 mme ke 3.1 mg / l. Ka tsamaiso ea molomo ea 400 mg ea moriana hang ka letsatsi, litekanyetso tse phahameng le tse tlase tsa ntho e maling li 3.2 mg / L le 0,6 mg / L, ka ho latellana. Ha moxifloxacin a kena kahare ka lijo, ho na le keketseho e sa lekanyetsoang ea nako ea ho fihlela khatello e kholo (hoo e ka bang lihora tse 2) le phokotso e fokolang ea khatello e kholo (e ka bang 16%). Tabeng ena, nako ea ho inkela e lula e sa fetoha. Leha ho le joalo, datha tsena ha li na bohlokoa ba bongaka bo bong, ka hona Avelox e lumelletsoe ho sebetsa ho sa tsotelehe takatso ea lijo.

Kamora ho ts'oaroa ho le leng ha Avelox ka tekanyetso ea 400 mg bakeng sa hora e le 'ngoe, boholo bo phahameng ba ntho bo fihlella qetellong ea infusion mme e ka ba 4.1 mg / l, e lumellanang le keketseho ea hoo e ka bang 26% ha e bapisoa le boleng ba paramente ena ka tsamaiso ea molomo ea moxifloxacin.

Pontšo ea moxifloxacin, e reriloeng ke letšoao la AUC, e feta hanyane ho feta ea tsamaiso ea molomo ea moxifloxacin. Boaoavailability e felletseng e ka ba 91%. Kamora ho kenella kahare ho infusions kahare ho Avelox ka tekanyetso ea 400 mg e lulang e le 1 nako e le 'ngoe ka letsatsi, maemo a phahameng le a tlase a moxifloxacin maling a fapana ka kakaretso ea 4.1-5.9 mg / l le 0.43-0.84 mg / l, ka ho latellana. Kakaretso e tsitsitseng ea 4.4 mg / L e fihlella qetellong ea infusion.

Setlhare sena se tsamaisoa ka potlako litho le liseleng. Tekanyo ea eona ea ho tlama liprotheine tsa mali (haholo albin) e batla e le 45%. Bophahamo ba thomello bo fihla ho 2 l / kg.

Metsoako ea bohlokoa ea moxifloxacin, e fetang ea plasma ea mali, e tlalehiloe ka ho kenella ka har'a maqhubu a letlalo), lisele tsa matšoafo (ho kenyelletsa li-macrophages tsa alveolar le mokelikeli oa li-epithelial), polyps ea nasal le sinuses (sinmoid le maxillary sinuses). Ka mokelikeli le mokelikeli oa lipakeng, karolo e sebetsang ea Avelox e ikemiselitsoe ka sebopeho sa eona sa mahala (ntle le ho itlama ka liprotheine) le lipalo tse phahameng ho feta plasma ea mali. Hape, boemo bo phahameng ba moxifloxacin bo fumanoa ka hara litho tsa botšehali tsa basali, mokelikeli oa peritoneal le lisele tsa litho tsa ka mpeng.

Moxifloxacin e kenella ts'ebetsong ea biotransformation ea karolo ea bobeli mme e ntšoa 'meleng ho tsoa ka moroto le mantle. Ho feta moo, e fumaneha ka sebopeho se sa fetoheng le ka sebopeho sa metsoako ea sulfo (M1) le glucuronides (M2), tse se nang ts'ebetso ea meriana.

Lithethefatsi ha li amehe liketsong tsa likokoana-hloko ka lebaka la ho pepesetsoa ts'ebetso ea microsomal ea cytochrome P₄₅₀. Litekanyetso tsa Plasma tsa M1 le M2 metabolites li tlase ho feta tsa karolo ea batsoali. Liphetho tsa lithuto tsa preclinical li bontša hore ha ho na phello e mpe ea li-metabolites tsena 'meleng ho latela mamello le polokeho ea tsona.

Bophelo ba halofo ea moxifloxacin e ka ba lihora tse 12. Ka karolelano, ho hlakoloa ka botlalo ka mor'a ho alafshoa ha moriana ka tekanyetso ea 400 mg ke 179-246 l / min. Tlhahiso ea leseli e fihla ho 24-53 ml / min. Sena se tiisa hore ntho e itseng e nchafalitsoeng ka mokokotlong oa ntho e itseng.

Tekanyo ea boima ba moxifloxacin le phaseite ea phase 2 ke hoo e ka bang 96-98%, e bontšang ho ba sieo ha metabolism ea oxidative. Hoo e ka bang 22% ea tekanyetso e le 'ngoe ea Avelox (400 mg) ha e sa fetoloa ka har'a moroto,' me e ka ba 26% ka mantle.

Ha u ithuta ka pharmacokinetics ea moxifloxacin ho bakuli ba batona le ba batšehali, li-AUC le ho tsepamisa mohopolo ho phahameng ho fapana ka 33%. Ho amoheloa ha ntho ha hoa itšetleha ka bong. Phapang e teng ho AUC le ho tsepamisa mohopolo haholo li ka etsahala ka lebaka la phapang ea boima ba 'mele, eseng bong,' me ha li na bohlokoa ba bongaka.

Phapang e kholo ho li-pharmacokinetics ea moxifloxacin ho bakuli ba lilemo tse fapaneng le ba merabe e fapaneng ha e so tsejoe. Mofuta oa pharmacokinetics oa moxifloxacin ho bana hajoale ha o utloisisehe hantle.

Ho bakuli ba sebetsanang le nako e telele ea peritoneal dialysis motheong o tsoang kapa hemodialysis e sa khaotseng, hammoho le ho bakuli ba nang le bothata ba methapo ea kutlo (ho kenyelletsa le bakuli ba nang le CC ka tlase ho 30 ml / min / 1.73 m 2), liphetoho tse kholo ho pharmacokinetics ea moxifloxacin ha lia ka tsa fumanoa. Phapang e kholo khoebong ea moxifloxacin ho bakuli ba nang le ts'ebetso ea sebete e sa sebetseng (litlelase A le B ho latela sekhahla sa bana-Prag) ha li bapisoa le bakuli ba ts'ebetso e tloaelehileng ea sebete le baithaopi ba phetseng hantle le bona ha ba eo.

Matšoao a ho sebelisoa

Ho latela litaelo, Avelox 400 mg e beoa bakeng sa:

• Ts'ebetso ea ts'oaetso ea matšoafo le litho tsa ENT,
• Lefu la intraabdominal le urogenital,
• Mafu a tšoaetsanoang a lisele tse bonolo le letlalo.

Ts'ebetso ea Avelox e bonts'oa mabapi le likokoana-hloko tse fapaneng tsa gram-positive le gram-negative, baktheria e hanyetsanang le lithibela-mafu tsa beta-lactam le macrolide, libaktheria tse hanyetsanang le acid le mefuta ea atypical ea likokoana-hloko, hammoho le libaktheria tsa anaerobic tse hananang le meriana.

Contraindication

Litaelo bakeng sa Avelox li bonts'a hore ts'ebeliso ea eona ha e amohelehe ho mafu a kang pseudomembranous colitis le ho hloleha ho matla hoa a renal. Ho thibetsoe ho nka lipilisi bakeng sa basali baimana le ba anyang, bana ba ka tlase ho lilemo tse 18 le batho ba nang le mamello ea motho ka mong likarolong tsohle tsa moriana. Ho hlokahala tlhokomeliso e khethehileng ha ho fanoa ka litlhare ho bakuli ba nang le mafu a tsamaiso ea methapo e kholo, ho fana ka maikutlo a monyetla oa ho tsubeloa ka mokhoa o sa tsitsang. Maloetse a kang ho hloleha ha sebete, ho ruruha ha myocardial ischemia, bradycardia, hypokalemia le hona ke lebaka la ho ba hlokolosi ha ho khethoa Aveloks.

Litaelo tsa ho sebelisa Avelox: mokhoa le litekanyetso

Li-Avelok li ka nkuoa ka nako efe kapa efe ea letsatsi, ho sa tsotelehe lijo tse ngata. Matlapa a metsitsoe a felletse, hobane botsitso ba khetla ea bona e ke ke ea tlotsoa. Bophelo ba halofo ea lithethefatsi ke mohato o molelele, ka hona ho lekane ho nka moriana ona hang ka letsatsi.

Sekhahla sa kalafo sa letsatsi le letsatsi sa Avelox ke 400 mg. Kamora ho tsamaisoa ka molomo, moriana o ananeloa ka potlako le ka botlalo. Palo e phahameng ea lithethefatsi maling ha e sebelisoa ka mokhoa o le mong ka mor'a lihora tse 0.5-4 ho tloha nakong ea tsamaiso. Ho fihlela boemo bo tsitsitseng ba plasma moxifloxacin ho etsahala kamora matsatsi a mararo a ts'ebeliso e tloaelehileng.

Phekolo ea infusion e etsoa mohlomong qalong ea kalafo ka phetisetso e tsoelang pele ea mokuli ts'ebeliso ea Avelox matlapeng, kapa e sebelisoa ho fihlela e fola.

Ho ipapisitse le bokuli, nako ea kalafo ke matsatsi a 7-10.

Litlamorao

Litla-morao tse fapaneng li etsahala ka seoelo, ho latela melao ea dosing. Avelox e ka baka litlamorao tse latelang tse mpe:

• Ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, ho latsoa tatso, stomatitis, lets'ollo,
• Ho eketseha ha sekhahla sa pelo, bohloko ba sefuba, ho phahamisa mala, khatello ea mali e eketsehileng,
• Ho tsekela, ho hlobaela boroko, khatello ea maikutlo, ho tšoenyeha, pherekano, bofokoli bo akaretsang,
• Bohloko ba morao, bohloko ba mesifa le manonyeletso, tendovaginitis, rupture ea tendon,
• Ho hlohlona, ​​makhopho a letlalo,
• Hyperglycemia, hyperlipidemia, hyperuricemia,
• Kakaretso malaise, ho ruruha.

Bongata

Hona joale, ho na le tlhaiso-leseling e fokolang mabapi le overdose ea Avelox. Ka tšebeliso e le 'ngoe ea lithethefatsi ka tekanyetso ea ho fihlela ho 1200 mg kapa ha e kenngoa ka tekanyetso e sa feteng 600 mg, ha ho litla-morao tse tlalehiloeng matsatsi a 10.

Maemong a bosholu, ho hlokahala hore u ithute ka hloko setšoantšo sa boemo ba mokuli le ho fana ka kalafo e tšehetsang matšoao a kopaneng le tlhahlobo ea ECG.

Ho ja khabone e sebelisitsoeng hang hang ka mor'a ho tsamaisoa ka molomo moxifloxacin 'meleng hangata ho thusa ho qoba ho pepesehela sethethefatsi ho latela ts'ebeliso ea bongoana haholo.

Litaelo tse khethehileng

Haeba ho na le bohloko manonyeletsong kapa makhophong ha u nka Avelox, sethethefatsi sea hlakoloa ho thibela ho phatloha ha tendon.

Ho bakuli ba nang le lefu la ho akheha, Avelox e ka 'na ea tsosa moferefere.

Ka nts'etsopele ea letšollo le matla ha u ntse u nka Avelox, e ea hlakoloa.

Takatso ea li-antacids le li-enterosorbents, hammoho le lithethefatsi tse kenyelletsang tšepe, aluminium le magnesium li lokela ho etsahala ka nako e fapaneng le Avelox, phapang e lokela ho ba bonyane lihora tse 4.

Avelox ha e sebelisoe ho phekola bana.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Ts'ebeliso ea Avelox e ka lebisa mathateng ho bakuli ha ba khanna makoloi le ha ba etsa mefuta e meng e ka bang kotsi ea mosebetsi e hlokang ho eketseha ha khatello ea maikutlo le litlamorao tsa psychomotor, ka lebaka la litlamorao tse ikhethang tsa lithethefatsi (ho senyeha hoa pono, litlamorao tse mpe tsamaisong ea methapo ea kutlo).

Bokhachane le pelehi

Tšireletseho ea tsamaiso ea moxifloxacin nakong ea kemolo ha e e-so thehisoe, ka hona ts'ebeliso ea eona e hanyetsitsoe. Litaba tsa tšenyo e kopanetsoeng e kopaneng ea bana ba nkileng li-quinolones lia tsebahala, empa phello ena ha e fumanoe ka popelong nakong ea kalafo le basali baimana ke Avelox.

Lithuto tsa liphoofolo li netefalitse tahi ea botona ea moxifloxacin. Tabeng ea batho, kotsi ea Avelox e ntse e ka utloisisoa hampe.

Moxifloxacin, joalo ka li-quinolones tse ling, e baka tšenyo ea mokokotlo oa manonyeletso a maholo ho liphoofolo tse tsoetsoeng pele ho nako. Boithuto ba pelehi bo bonts'a hore moxifloxacin, maemong a manyane, e fetela lebeseng la matsoele. Tlhahisoleseling mabapi le ts'ebeliso ea eona ho bakuli nakong ea lactation ha e fumanehe, ka hona, ts'ebeliso ea eona nakong ea ho anyesa e hatelloa.

Fomu ea tokollo, sebopeho le sephutheloana

Matlapa a koahetsoeng ke Avelox:

• Letlapa le le leng le na le moxifloxacin (ka sebopeho sa hydrochloride) - 400 mg
  ka lebokoseng la 1 blister bakeng sa li-pcs tse 5 kapa 7, kapa ka lebokoseng mabokose a 2 a li-pcs tse 5.

Tharollo ea ts'ebetso ea Avelox:

• Botlolo e le 1 e na le moxifloxacin (ka sebopeho sa hydrochloride) - 400 mg
  metsoako e meng: sodium chloride, sodium hydroxide, hydrochloric acid, metsi d / le.
  250 ml -1 botlolo ka lebokoseng.

Tharollo ea ts'ebetso ea Avelox:

• Pakete e le 'ngoe e na le moxifloxacin (ka sebopeho sa hydrochloride) - 400 mg
  metsoako e meng: sodium chloride, sodium hydroxide, hydrochloric acid, metsi d / le.
  250 ml - mekotla ea polyolefin (1) - mekotla ea polasetiki e lohiloeng ka foil (12) ka lebokoseng.

Ketso ea pharmacological

Moxifloxacin ke sethethefatsi se thibelang likokoana-hloko se nang le sebopeho se fapaneng sa ketso ea letoto la fluoroquinolone. Tšusumetso ea "bactericidal" ea lithethefatsi e bakoa ke ts'oaetso ea "bacteric topoisomerases" ea II le IV, e lebisang ho sitisongeng hoa biosynthesis ea DNA ea sele ea microbial, ka lebaka leo, lefung la lisele tse likokoana-hloko. Tekanyo e nyane ea bactericidal ea lithethefatsi hangata e bapisoa le botebo ba eona bo fokolang ba ho inhibitory.

Mechine e isang nts'etsopele ea ho hanela li-penicillin, cephalosporins, aminoglycosides, macrolides le tetracyclines ha e senye mosebetsi oa antibacterial oa moxifloxacin.Ha ho na khanyetso pakeng tsa lihlopha tsena tsa lithethefatsi tsa antibacterial le moxifloxacin. Ho fihlela hajoale, ha ho e-so be le maemo a hanyetsano ea plasmid. Khafetsa e akaretsang ea kholo ea khanyetsano e nyane haholo (10 7 - 10 10). Khanyetso ea Moxifloxacin e tsoela pele butle butle ka liphetoho tse ngata. Ho pepesetsoa khafetsa moxifloxacin ho likokoana-hloko tse ho tsetelang ka tlase ho tekanyetso e nyane ea inhibitory (MIC) ho tsamaisana le keketseho e nyane feela ea MIC. Ho hlokomeleha maemo a ho hanyetsoa ha quinolones. Le ha ho le joalo, likokoana-hloko tse ling tse ntle tsa gram le anaerobic tse hananang le li-quinolones tse ling li lula li tsotella moxifloxacin.

In vitro moxifloxacin e sebetsa khahlano le likokoana-hloko tse fapaneng tsa gram-negative le gram-positive, anaerobes, libaktheria tse hanyetsanang acid le mefuta ea atypical, tse kang Mycoplasma, Chlamidia, Legionella, hammoho le libaktheria tse hanyetsanang le lithibela-mafu tsa ß-lactam le mafolid.

Ke eng e thusang Avelox?

Matšoao a mantlha a ho khethoa ha Avelox ke maemo / maloetse a latelang:

• Ts'ebetso ea ts'oaetso ea matšoafo le litho tsa ENT,
• Lefu la intraabdominal le urogenital,
• Mafu a tšoaetsanoang a lisele tse bonolo le letlalo.

Ts'ebetso ea Avelox e bonts'oa mabapi le likokoana-hloko tse fapaneng tsa gram-positive le gram-negative, baktheria e hanyetsanang le lithibela-mafu tsa beta-lactam le macrolide, libaktheria tse hanyetsanang le acid le mefuta ea atypical ea likokoana-hloko, hammoho le libaktheria tsa anaerobic tse hananang le meriana.

Boimana

Tšireletseho ea tšebeliso ea moxifloxacin nakong ea kemolo ha e e-so thehisoe le ts'ebeliso ea eona e hanyetsanoe. Litaba tsa tšenyo e kopanetsoeng e kopaneng ea bana ba fumanang li-quinolones li hlalosoa, leha ho le joalo, ponaletso ea phello ena ho lesea (ha le sebelisoa ke mme nakong ea kemolo) ha ea tlalehoa.

Lithuto tsa liphoofolo li bontšitse chefo ea ho beleha. Kotsi e ka bang teng ho batho ha e tsejoe.

Joalo ka li-quinolones tse ling, moxifloxacin e baka tšenyo ea mokokotlo oa manonyeletso a maholo ho liphoofolo tse tlang pele ho nako. Boithuto ba pelehi bo fumane hore palo e nyane ea moxifloxacin e epuoa lebeseng la matsoele. Boitsebiso ka ts'ebeliso ea eona ho basali nakong ea mkasi ha e fumanehe. Ka hona, ho khethoa ha moxifloxacin nakong ea kanyeso ho kopantsoe.

Ho sebelisana le lithethefatsi

Ka motsoako oa moxifloxacin o nang le probenecid (ho se be teng ha tšebelisano ea bohlokoa ka bongaka le karolo e sebetsang ea Avelox e netefalitsoe), atenolol, morphine, livitidine, digoxin, itraconazole, li-calcium tse nang le likhalase tsa molomo, glibenclamide, theophylline, lithibela-pelehi tsa molomo, cyclosporin ha li hlokahale.

Ka tšebeliso e kopaneng ea Avelox le lithethefatsi tse amang ho lelefatsa nako ea QT, phello e tlatsetsang ea ho lelefatsa nako ea QT e ka bonoa. Ka motsoako oa moxifloxacin le lithethefatsi tse tšoanang le ena, menyetla ea ho ba le li-ventricular arrhythmias, ho kenyelletsa polymorphic ventricular tachycardia (torsade de pointes) e eketsehile.

Tsamaiso ea tšebeliso ea moxifloxacin le lithethefatsi tse latelang tse amang nako e telele ea QT li hanyetsitsoe:

• antihistamines (misolastine, astemizole, terfenadine),
• Lithethefatsi tsa antiarrhythmic tsa sehlopha sa IA (disopyramides, hydroquinidine, quinidine, jj.),
• lithethefatsi tsa sehlopha sa antiarrhythmic tsa class (ibutilide, amiodarone, dofetilide, sotalol, jj.),
• antimicrobials antimalarials, haholo-holo halofantrine, sparfloxacin, pentamidine, erythromycin (tsamaiso ea methapo),
• santantantanthuri
• antipsychotic (suloprid, phenothiazine, haloperidol, sertindole, pimozide, jj),
• diphemanil tse ling, cisapride, bepridil, vincamine (tsamaiso ea methapo ea kutlo).

Ts'ebetso e ts'oanang ea Avelox e nang le li-multivitamine, liminerale le li-antacid li ka baka ho koenya ha moxifloxacin ka lebaka la sebopeho sa li-chelate complexes tse nang le likarolo tse ngata tsa karolo ea litlhare tsena. Ka lebaka leo, boemo ba moxifloxacin ho plasma ea mali bo ka ba tlase haholo ho feta kamoo ho hlokahalang. Ka hona, lithibela-mafu (mohlala, didanosine) le litokisetso tsa antacid le lithethefatsi tse ling tse kenyeletsang aluminium kapa magnesium, hammoho le sucralfate le lithethefatsi tse ling tse nang le zinki kapa tšepe, li khothaletsoa ho nooa bonyane lihora tse 4 pele kapa lihora tse 4 kamora tsamaiso ea molomo oa Avelox.

Ka ho kopantsoe ha Avelox le warfarin, nako ea prothrombin le likarolo tse ling tsa coagulation ea mali li lula li sa fetoha. Ho bakuli ba tšoaroang ke li-anticoagulants hammoho le lithibela-mafu, linyeoe tsa ts'ebetso ea anticoagulant ea lithethefatsi tsa anticoagulant lia hlokomeloa.

Lintho tse kotsi li kenyelletsa boemo bo akaretsang ba lilemo le mokuli, hammoho le ho ba teng ha lefu le tšoaetsanoang le tsamaeang le ts'ebetso ea ho ruruha. Ho sa tsotelehe taba ea hore ts'ebelisano ea moxifloxacin le warfarin ha e so netefatsoe ho fihlela joale, bakuli ba fumanang phekolo e nang le meriana ena ba lokela ho lekola INR kamehla, mme ha ho hlokahala, eketsa kapa ho fokotsa tekanyetso ea anticoagulants.

Digoxin le moxifloxacin ha e le hantle ha e ame maemo a pharmacokinetic e mong le e mong. Ka ts'ebetso ea litekanyetso tse phetoang tsa Avelox, palo e phahameng ea digoxin e eketsehile ka 30%. Tabeng ena, boholo ba boholo ba digoxin le boleng ba sebaka se tlas'a "khatello ea nako" ea "pharmacokinetic" ha li fetohe.

Ka tsamaiso e tšoanang ea molomo ea moxifloxacin ka tekanyo ea 400 mg mme e entsoe mashala, ts'ebetso ea bioavailability ea Avelox e fokotseha ka ho feta 80% ka lebaka la thibelo ea ho monya. Maemong a bosholu ba tšebeliso ea ts'ebeliso ea ts'ebeliso ea khase e ts'ebetsong qalong ea ho hula ho thibela keketseho e eketsehileng ponts'o ea kemiso.

Litla-morao tsa Avelox nthong e sebetsang ke lithethefatsi tse latelang: Vigamox, Moximac, Moxin, Moxifloxacin, Moxifloxacin hydrochloride, Plevilox. Subgroup e tšoanang ea pharmacological e kenyelletsa: Abactal, Basigen, Gatispan, Geoflox, Zanocin, Xenaquin, Levoflox, Normax, Ofloxacin, Ciprofloxacin le ba bang.

Litlhahlobo mabapi le Aveloks

Maikutlo mabapi le Avelox e siiloeng ke litsebi a likhang haholo. Lingaka tse ling li e nka e le lithibela-mafu tse matla le tse sebetsang tse thusang ho sebetsana ka katleho le motsoako oa lisosa oa mafu a kang chlamydia, pyelonephritis, feberu, SARS, le E. coli. Litsebi tse ling li re ha ho na liphetho tse ntle tsa kalafo, empa li hlokomela litlamorao tse ngata.

Maikutlo a bakuli mabapi le Avelox le 'ona a tsoakiloe. Batho ba bangata ba bolela lintho tse sa thabiseng joalo ka ho fokotseha ha takatso ea lijo le ho nyekeloa. Leha ho le joalo, bakuli ba bangata ba e nka e le lithethefatsi tse matla le tse sebetsang tsa antibacterial.

Sebopeho le mofuta oa tokollo

Avelox e fumaneha ka mokhoa oa litafole le tharollo ea infusion (eseng bakeng sa ente). Ithute ka sebopeho, litlhaloso le litlhaloso tse khutšoane tsa lithethefatsi:

Pink, matte, oblong, filimi e koahetsoeng.

Mokelikeli o pherese o bosehla bo bosehla.

Khatello ea moxifloxacin, mg

400 bakeng sa botlolo e le 'ngoe

Titanium dioksidi, cellulose ea microcrystalline, macrogol, scroscarmellose, oxide e khubelu ea tšepe, lactose monohydrate, hypromellose

Metsi, sodium chloride, hydrochloric acid, tharollo ea sodium hydroxide.

Lithutso tsa li-pcs tse 5 kapa 7.

Li-vials tse 250 ml kapa lijana.

Tekanyetso le tsamaiso

Hangata lingaka li beha Avelox bakeng sa angina, abscess, pneumonia, ka lebaka la antibacterial athari, lithethefatsi li bolaea li-causative agents tsa ts'oaetso mme li imolla ho ruruha. Mokhoa oa ts'ebeliso, mokhoa oa ho fokotsa litekanyetso le hore na nako ea phekolo e joang, ho latela mofuta oa lefu lena le boima ba lona. Matlapa a nooa ka molomo, tharollo ke ea batsoali, ka tsela ea infusions.

Avelox matlapeng a nkoa ka molomo ka 400 mg 1 nako / letsatsi. Matlapa ha a hlafuna, a hlatsuoa ka metsi, ho sa tsotelehe lijo. Botsofaling, litekanyetso ha li fetohe. Nako ea kalafo e ipapisitse le lefu lena:

Tsela ea kalafo ka matsatsi

Ho eketseha ha bronchitis e sa foleng

Pneumonia e fumanoeng ke sechaba ka mor'a thuto ea Avelox

Tharollo ea infusion

Bakeng sa tšebeliso ea methapo, tharollo ea lebitso le tšoanang ka lethal dose ea 400 mg hang / ka letsatsi e reretsoe. Phekolo ea lithethefatsi e nka matsatsi a 21. Ka pneumonia e fumanoeng ke sechaba, kalafo e nka matsatsi a 7-14, le ts'oaetso e rarahaneng - matsatsi a 7-21, le tšoaetso ea mpa - matsatsi a 5-14. Bakeng sa batho ba baholo le bakuli ba nang le ts'ebetso ea sebete e sa sebetseng, litekanyetso ha li fetohe.

Tharollo e fanoa ka methapo bakeng sa hora. Setlhare se ka sebelisoa ka ho hlapoloha ka metsi, tharollo ea Ringer, sodium chloride, dextrose kapa xylitol. Ke tharollo feela e hlakileng e hlahisoang ntle le turbidity, sediment. Kamora ho hlapoloha ka liliki, setlama se ts'oareha letsatsi lohle, ha feela se bolokiloe ka mocheso oa kamore.

Nakong ea kemolo

Tšireletseho ea tšebeliso ea moxifloxacin nakong ea kemolo ha e e-so thehisoe, ka hona ts'ebeliso ea eona e hanyetsitsoe. Boithuto ho likhoto bo bontšitse chefo ea ho beleha. Ho liphoofolo, Moxifloxacin e baka tšenyo ea mokokotlo oa manonyeletso a maholo, a kentsoeng lebeseng la matsoele, ka hona kalafo e fanoang ka matsoele e hlakotsoe.

Bocheng

Avelox e ke ke ea sebelisoa bongoaneng le bohlankaneng ka tlase ho lilemo tse 18. Sena se amahanngoa le kotsi e eketsehileng ea ho senyeha ha ts'ebetso ea manonyeletso le lefufuru. Ho pepesehela lithibela-mafu haholo ho ka lebisa chefo, nts'etsopele ea makhopo a mangata haholo, khatello ea maikutlo le khatello ea maikutlo ea methapo ea methapo. Sena se kotsi haholo lilemong tsa bocha le har'a bana ba sekolo.

Avelox le joala

Ho qoba kotsi ea likotsi tsa sebete tse ka bang teng, bakeng sa nako ea kalafo ea Avelox, o lokela ho hana ho nka lino tse tahang kapa lithethefatsi. Tšebeliso e tahang ea tahi e senya litho tsa ka, e baka tahi e ngata le ho lemalla joala haholo. Ethanol e fokotsa ts'ebetso ea lithethefatsi, e lebisang liphellong tse mpe tse mpe. U ka qala ho e nka khoeli kamora ho fela ha kalafo.

Lipehelo tsa thekiso le polokelo

Avelox e rekisoa ka taelo, e bolokiloe ka mocheso ho isa ho li-degrees tsa 25 bakeng sa litafole le likhato tse 15-30 bakeng sa tharollo. Bophelo ba sehatsetsing ba litafole le likhaba tsa tharollo ke lilemo tse hlano, tharollo e ka lijaneng ke lilemo tse tharo.

Lijenereithara tse nang le ntho e tšoanang e sebetsang le tse nkang karolo e 'ngoe, empa ka ts'ebetso e ts'oanang ea ts'ebetso, li fetisoa ho liAllok analogues. Lingoloa tsa lithethefatsi tsa antimicrobial:

• Aquamox - tharollo e thehiloeng moxifloxacin,
• Moxifluor ke mofuta oa meriana eo ho buuoang ka eona.
• Megaflox - matlapa a nang le motsoako o tšoanang,
• Hainemoks - ho hlophisoa ha letlapa, analogue ka kotloloho,
• Moxifloxacin ke motsoako oa lithethefatsi o tsebahalang ka ho fetisisa.

Litaelo tsa ho sebelisoa (Mokhoa le litekanyetso)

Matlapa a nooa ntle le ho hlafuna kapa ho arohana, ho sa tsotelehe lijo.

Ho latela litaelo tsa Avelox 400 mg, ho batho ba baholo, litekanyetso tsa letsatsi le letsatsi ke pilisi e le 'ngoe kapa 400 mg ea antibiotic.

Nako le mokhoa oa tsamaiso li lokela ho khethoa ke ngaka e eang, ho latela boholo ba ts'oaetso, ts'ebetso ea eona le kutloelo-bohloko ea mokuli.

E le molao, qalong ea kalafo, sethethefatsi se laetsoe ka liente, joale, kamora ho qala ho ntlafatso, matlapa a ka ngolloa.

Ka ho eketsa sa folengbronchitis Nako ea kalafo ka lithethefatsi ke matsatsi a 5. Ho pneumonia - ho tloha ho 7 (liente) ho isa matsatsi a 10.

Ho sinusitis e matla le ts'oaetso e bobebe ea letlalo le lisele, nako ea ts'ebetso ea lithibela-mafu ke beke e le 'ngoe.

Ka ts'oaetso e sa rarahanang ea litho tsa pelvic, nako ea phekolo ke libeke tse peli.

Tabeng ea ts'oaetso e rarahaneng ea letlalo le likarolo tlas'a letlalo, kalafo e etsoa butle mme e nka matsatsi a 5 ho isa libeke tse peli.

Ho batho ba nang le bothata ba ho ba le masapo a mokokotlo oa mokokotlo le oa hepatic, ba tsofetseng, le bakeng sa merabe e fapaneng, phetoho ea litekanyetso ha e etsoe.

Litaelo tsa ho sebelisa Avelox ea ente

Sebelisa tharollo e hlakileng feela, ntle le hore u be le marang-rang.

Setlhare se fanoa ka methapo nako e telele, metsotso e 60, bonyane ntle le ho hlapolloha. Hape khafetsa lithibela-mafu li tsoakoa le Adapta ea T ka metsi bakeng sa ente tharollo ea sodium chloride(0.9% kapa 1M), tharollo dextrose (5%, 10%, 40%), tharollo xylitol 20%, Tharollo ea ringer. Motsoako o hlophisitsoeng o ka bolokoa ka mocheso oa kamore lihora tse 24.

Ka syringe e le 'ngoe kapa li-dropper, li-agents tse ling ha li tsoakane.

Tšebelisano

E sebetsa hantle le atenolol, theophylline, calcium litokisetso, ranitidine, lithibela-pelehi tsa molomo, intraconazole, morphine, glibenclamide, digoxin, warfarin, probenecid.

Leha ho le joalo, ha e kopantsoe le anticoagulants e sa tobang e lokela ho nahanoa le ho hlahlojoa nako le nako INRka nepahalo tekanyetso ea lithibela-mafu.

Ha e kopantsoe le li-antacids, li-multivitamine mme liminerale lia thehoa qhekella Mechini e rarahaneng e nang le li-cation tsa polyvalent, motsoako oa lithibela-mafu maling o fokotseha. Mabapi le sena, nako ea lihora tse 4 pakeng tsa ho sebelisa litlhare e lokela ho bonoa.

Haeba u kopanya moriana le k'habone e entsoeng kapa tse ling hangosorbents, ebe bioavailability ea lithethefatsi e fokotsehile haholo (hoo e ka bang 80%). Ka tsamaiso ea methapo, palo ena e fihla ho 20%.

Tharollo ea infusion ha ea lokela ho fanoa ka 10% le 20% sodium chloride, sodium hydrogencarbonate 4,2% le 8,4%.

Likhatiso tsa Avelox

Litšoantšo tse atamelaneng haholo tsa Avelox: Moxifloxacin-Farmex, Moxifloxacin, Moxifluor, Moflox, Moxifloxacin-Kredofarm, Maxicin, Moxifluor 400, Moxin, Tevalox, Mofloxin Lupine.