Insulin aspart mekhahlelo e 'meli

Litokisetso tse kopaneng tsa insulin, analogue ea insulin ea motho. Ho emisoa ha biphasic ho kenyelletsa soluble insulin aspart (30%) le likristale tsa insulin protart (70%). Insulin aspart e fumanoeng ke theknoloji ea DNA e kopantsoeng e sebelisa mofuta oa Saccharomyces cerevisiae, sebopeho sa limolek'hule, amino acid proline e maemong a B28 e nkeloa sebaka ke aspartic acid.

Thutela-litso

Biphasic insulin aspart e buisana le li-receptor tse ikhethang tsa membrane ea cytoplasmic ea lisele mme e etsa mochine oa "insulin-receptor" o khothalletsang ts'ebetso ea methapo, ho kenyeletsa synthetese ea li-enzymes tse 'maloa tsa bohlokoa (hexokinase, pyruvate kinase, glycogen synthetase). Ho fokotseha ha tekanyo ea tsoekere maling ho bakoa ke ho eketseha ha sephethe-phethe sa eona, ho eketseha ha mesifa le marapo a adipose, le phokotso ea sekhahla sa tlhahiso ea tsoekere maling. E na le ts'ebetso e tšoanang le ea insulin ea motho ka tsela e lekanang. Ho ts'oaroa ha proline ea amino acid e maemong a B28 ka aspic acid ho fokotsa tloaelo ea limolek'hule tsa ho theha li-hemogle karolong e qhibilihang ea lithethefatsi, e bonoang ka insulin ea metsi a qhibilihang. Ntlheng ena, insulin aspart e nkuoa ho tsoa ho mafura a subcutaneous ka potlako ho feta insulin e qhibilihang e fumanehang ka insulin ea insulin. Protulin ea "insulin" e kenngoa nako e telele. Kamora ho tsamaisoa ha sc, phello e ba teng kamora metsotso e 10-20, phello e kholo kamora lihora tse 1 - 4, nako ea tšebetso e fihla ho lihora tse 24 (ho latela tekanyetso, sebaka sa tsamaiso, matla a phallo ea mali, mocheso oa mmele le boemo ba ts'ebetso ea 'mele).

Ha s / ho ea tekanyetso ea boima ba 'mele ea 0,2 U / kg T_max - Metsotso e 60 Ho tlama liprotheine tsa mali li tlase (0-9%). Serum insulin e khutlela ho ea mantlha kamora lihora tse 15-18.

Bokhachane le pelehi

Ts'ebeliso nakong ea bokhachane e ka etsahala haeba phello e lebelletsoeng ea kalafo e feta tlokotsi e ka bang teng ho lesea (lithuto tse lekaneng le tse laoloang ka thata li sa etsoa). Ha ho tsejoe hore na insulin aspart biphasic e ka ba le phello ea embryotoxic ha e sebelisoa nakong ea kemolo le hore na e ama bokhoni ba ho ba le bana.

Nakong ea ho qala ha bokhachane le nakong eohle ea nako ea bona, ho hlokahala hore ho hlahlojoe ka hloko boemo ba bakuli ba nang le lefu la tsoekere le ho hlokomela boemo ba tsoekere maling. Tlhokahalo ea insulin, joalo ka molao, e fokotseha ho trimester ea pele mme butle-butle e eketseha ka li-trimesters tsa bobeli le tsa boraro tsa boimana.

Nakong ea tlhaho ea ngoana le hang ka mor'a bona, tlhoko ea insulin e ka fokotseha haholo, empa ka potlako e khutlela boemong bo neng bo le pele ho ima.

Ha ho tsejoe hore na moriana o fetela lebeseng la matsoele. Nakong ea ho nyekeloa, ho ka ba le tlhoko ea tokiso ea litekanyetso.

Insulin aspart biphasic: Litla-morao

Edema le phoso ea ho pheta-pheta (qalong ea kalafo), litla-morao tsa lefu la sethoathoa (hyperemia, ho ruruha, ho hlohlona ha letlalo sebakeng sa ente), methapo e akaretsang ea letlalo (ho senyeha ha letlalo, ho hlohlona, ho eketseha ha mofufutso, ho senyeha ha mpa, ho thatafala ha mali, angioedema edema), lipodystrophy setsing sa ente.

Tšebelisano

Phallo ea insulin ea mekhahlelo e 'meli ha e lumellane ka litlhare le litlhare tsa lithethefatsi tse ling. Phello ea hypoglycemic e ntlafatsoa ke lithethefatsi tsa molomo tsa hypoglycemic, sulfanilamides, li-inhibitors tsa MAO (ho kenyelletsa furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, li-inhibitors tsa ACE, li-anabolic steroids (ho kenyelletsa stanozolol, oxandrolone, metroprotinol le tetroprotinol tetrostanes) , disopyramide, fibrate, fluoxetine, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, pyridoxine, quinidine, quinine, chloroquine, ethanol le lithethefatsi tse nang le ethanol. litla Hypoglycemic tsa glucocorticoids litsebeng, glucagon, khōlo hormone, li-hormone thyroid, estrogens, progestogens (mohlala lithibela-pelehi molomo), thiazide diuretics, CCB, heparin, sulfinpyrazone, sympathomimetics (tse kang epinephrine, salbutamol, terbutaline), isoniazid, phenothiazine derivatives, danazol, tricyclics, diazoxide, morphine, nicotine, phenytoin.

Beta-blockers, clonidine, lithium salts, reserpine, salicylates, pentamidine - e ka matlafatsa le ho fokolisa phello ea hypoglycemic ea insulin.

Biphasic insulin aspart: Tekanyetso le tsamaiso

P / c, hang-hang pele ho lijo, haeba ho hlokahala - hang ka mor'a lijo. Ente e etsoa thipa kapa ka mpeng ea mpa ea mpa, kapa lehetleng kapa mokokotlong. Hoa hlokahala ho fetola sebaka sa ente kahare ho sebaka sa anatomical (ho thibela nts'etsopele ea lipodystrophy). Mocheso oa "insulin" o sebelisoang o lokela ho ba ka mocheso oa kamore.

Tekanyetso ea insulin aspart biphasic e khethoa ke ngaka ka bonngoe boemong bo bong le bo bong, ho ipapisitse le khatello ea mali maling. Ka karolelano, lethal dose ea letsatsi le letsatsi ke boima ba 'mele ea 0.5-1 / kg. Ka ho hanyetsa insulin (ho etsa mohlala, ka botenya), tlhoko ea insulin ea letsatsi le letsatsi e kanna ea eketsoa, 'me ho bakuli ba nang le masapo a amanang le insulin.

Litlhokahalo tsa polokeho

Likarolo tsa "insulin" tsa mekhahlelo e 'meli ha lia lokela ho tsamaisoa iv. Tekanyetso kapa tekanyetso e sa lekaneng ea kalafo (haholo-holo ka lefu la 1 lefu la tsoekere) e ka lebisa kholong ea hyperglycemia kapa lefu la tsoekere. Ha e le molao, hyperglycemia e iponahatsa butle-butle ka lihora tse ngata kapa matsatsi (matšoao a hyperglycemia: ho nyekeloa, ho hlatsa, ho otsela, ho omella le ho omella hoa letlalo, molomo o omileng, mokokotlo o eketsehileng, lenyora le ho felloa ke takatso ea lijo, ponahalo ea lephoka la asiti moeeng o tsoileng moeeng), mme ntle le kalafo e loketseng e ka lebisa lefung.

Kamora ho lefa tefo ea metabolism ea carbohydrate, ka mohlala, nakong ea kalafo e matla ea insulin, bakuli ba ka ba le matšoao a tloaelehileng a lingaka tsa hypoglycemia, tseo bakuli ba lokelang ho tsebisoa ka tsona. Ho bakuli ba nang le lefu la tsoekere ba nang le taolo e nepahetseng ea metabolic, mathata a morao a lefu la tsoekere a tsoela pele le ho tsoela pele butle butle. Ntlheng ena, ho khothalletsoa ho etsa mesebetsi e reretsoeng ho ntlafatsa taolo ea metabolic, ho kenyelletsa le ho lekola boemo ba tsoekere maling.

Mokhahlelo oa "insulin" oa mekato e 'meli o lokela ho sebelisoa mabapi le ho ja lijo. Hoa hlokahala ho nahana ka lebelo le phahameng la ho qala ha phello ho kalafo ea bakuli ba nang le mafu a kopaneng kapa ho sebelisa lithethefatsi tse fokotsang ho kenngoa ha lijo. Ha ho na le mafu a kopaneng, haholo-holo a nang le tšoaetso, tlhoko ea insulin e ntse e eketseha. Ts'ebetso ea renal e senyehileng le / kapa ea sebete e ka lebisa ho fokotseha hoa litlhoko tsa insulin. Ho tlōla lijo kapa ho ikoetlisa ka tsela e sa reroang ho ka lebisa ho holiseng hypoglycemia.

Ka nts'etsopele ea hypoglycemia kapa hyperglycemia, ho fokotseha hoa maikutlo le lebelo la karabelo ho ka etsahala, ho ka bang kotsi ha o khanna koloi kapa o sebetsa ka mechine le metjeko. Bakuli ba lokela ho eletsoa ho nka mehato ea ho thibela nts'etsopele ea hypoglycemia le hyperglycemia. Sena ke sa bohlokoa haholo ho bakuli ba se nang matšoao a tlisoang ke ho ba le hypoglycemia kapa ba nang le liketsahalo tsa khafetsa tsa hypoglycemia.

Mabitso a Khoebo

NovoMix 30 Penfill: ho emisoa bakeng sa tsamaiso e potolohang ea 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 30 FlexPen: ho emisoa bakeng sa tsamaiso e potolohang ea 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 50 FlexPen: ho emisoa bakeng sa tsamaiso e potolohang ea 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 70 FlexPen: ho emisoa bakeng sa tsamaiso e potolohang ea 100 PIECES / ml, Novo Nordisk (Denmark)

Ketso ea pharmacological

E sebetsana le li-receptor tse ikhethang tsa membrane ea cytoplasmic ea lisele mme e theha mohopolo oa "insulin-receptor" o kenyelletsang ts'ebetso ea methapo, ho kenyeletsa synthetese ea li-enzymes tse 'maloa tsa bohlokoa (hexokinase, pyruvate kinase, glycogen synthetase). Ho fokotseha ha tekanyo ea tsoekere maling ho bakoa ke ho eketseha ha sephethe-phethe sa eona, ho eketseha ha mesifa le marapo a adipose, le phokotso ea sekhahla sa tlhahiso ea tsoekere maling. E na le ts'ebetso e tšoanang le ea insulin ea motho ka tsela e lekanang. Ho ts'oaroa ha proline ea amino acid e maemong a B28 ka aspic acid ho fokotsa tloaelo ea limolek'hule tsa ho theha li-hemogle karolong e qhibilihang ea lithethefatsi, e bonoang ka insulin ea metsi a qhibilihang. Ntlheng ena, insulin aspart e nkuoa ho tsoa ho mafura a subcutaneous ka potlako ho feta insulin e qhibilihang e fumanehang ka insulin ea insulin. Protulin ea "insulin" e kenngoa nako e telele. Kamora ho tsamaisoa ha sc, phello e ba teng kamora metsotso e 10-20, phello e kholo kamora lihora tse 1 - 4, nako ea tšebetso e fihla ho lihora tse 24 (ho latela tekanyetso, sebaka sa tsamaiso, matla a phallo ea mali, mocheso oa mmele le boemo ba ts'ebetso ea 'mele). Ha u le tekanyetso ea boima ba 'mele ea 0,2 U / kg - metsotso e 60 Ho tlama liprotheine tsa mali li tlase (0-9%). Serum insulin e khutlela ho ea mantlha kamora lihora tse 15-18.

Litšobotsi tsa ntho ena Insulin aspart biphasic

Litokisetso tse kopaneng tsa insulin, analogue ea insulin ea motho. Ho emisoa ha biphasic ho kenyelletsa soluble insulin aspart (30%) le likristale tsa insulin protart (70%). Insulin aspart e fumanoang ke theknoloji ea maqhubu a DNA e sebelisang mathata Saccharomyces cerevisiae, ka sebopeho sa limolek'hule tsa insulin, amino acid proline e maemong a B28 e nkeloa sebaka ke aspartic acid.

Litla-morao tsa ntho ena Insulin aspart biphasic

Bongata

Matšoao hypoglycemia - "ho bata" mofufutso, letšoele la letlalo, ho tšoha, ho thothomela, ho tšoenyeha, mokhathala o sa tloaelehang, bofokoli, ho ferekana, ho tsepamisa kelello, ho tsekela, tlala e matla, ho senyeheloa ke pono ha nakoana, hlooho e bohloko, ho nyekeloa, tachycardia, cramp, mathata a methapo coma.

Phekolo: mokuli a ka emisa hypoglycemia e nyane ka ho nka tsoekere, tsoekere kapa lijo tse nang le lik'habohaedreite tse ngata. Maemong a matla - ka / ka 40% tharollo ea dextrose, ka / m, s / c - glucagon. Kamora ho hlaphoheloa kelellong, mokuli o khothalletsoa ho ja lijo tse nang le lik'habohaedreite ho thibela nts'etsopele ea hypoglycemia.

Lintho tsa ho itšireletsa mafung insulin aspart biphasic

U ke ke ua kenya iv. Tekanyetso kapa tekanyetso e sa lekaneng ea kalafo (haholo-holo ka lefu la 1 lefu la tsoekere) e ka lebisa kholong ea hyperglycemia kapa lefu la tsoekere. Ha e le molao, hyperglycemia e iponahatsa butle-butle ka lihora tse ngata kapa matsatsi (matšoao a hyperglycemia: ho nyekeloa, ho hlatsa, ho otsela, ho omella le ho omella hoa letlalo, molomo o omileng, mokokotlo o eketsehileng, lenyora le ho felloa ke takatso ea lijo, ponahalo ea lephoka la asiti moeeng o tsoileng moeeng), mme ntle le kalafo e loketseng e ka lebisa lefung.

Moriana o lokela ho sebelisoa mabapi le ho ja lijo tse khethehileng. Hoa hlokahala ho nahana ka lebelo le phahameng la ho qala ha phello ho kalafo ea bakuli ba nang le mafu a kopaneng kapa ho sebelisa lithethefatsi tse fokotsang ho kenngoa ha lijo. Ha ho na le mafu a kopaneng, haholo-holo a nang le tšoaetso, tlhoko ea insulin e ntse e eketseha. Ts'ebetso ea renal e senyehileng le / kapa ea sebete e ka lebisa ho fokotseha hoa litlhoko tsa insulin. Ho tlōla lijo kapa ho ikoetlisa ka tsela e sa reroang ho ka lebisa ho holiseng hypoglycemia.

Ho fetisoa ha mokuli ho ea ho mofuta o mocha oa insulin kapa tokisetso ea insulin ea moetsi e mong ho tlameha ho etsoa tlasa tlhokomelo ea bongaka e thata, phetoho ea li-doses e ka hlokahala. Haeba ho hlokahala, phetoho ea tekanyetso e ka etsoa ka ente ea pele ea lithethefatsi kapa nakong ea libeke tsa pele kapa likhoeli tsa kalafo. Phetoho ea lethal dose e ka hlokahala ka phetoho ea lijo le ho ikoetlisa ka matla. Ho ikoetlisa hang ka mor'a ho ja ho ka eketsa kotsi ea hau ea hypoglycemia.

Molao-motheo oa tšebetso

Motsoako ona o tlama ho li-insulin receptor ho lithane tsa adipose le mesifa ea mesifa. Boemo ba tsoekere maling bo fokotseha ka lebaka la hore linama li khona ho monya tsoekere e ngata, ho feta moo, e kena hantle ka har'a lisele, ha tekanyo ea ho thehoa ha eona ka har'a sebete, ho fapana le moo, e fokotseha butle. Ts'ebetso ea ho petsoha mafura 'meleng e ea matla le ho potlakisa ho hlophisoa ha likarolo tsa protheine.

Ketso ea moriana e qala kamora metsotso e 10-20, mme ho kenella ha eona maling ho hlokomeleha ka mor'a lihora tse 1-3 (ke makhetlo a 2 ka potlako ha a bapisoa le lihormone tse tloaelehileng tsa motho). Insulin e joalo ea monocomponent e rekisoa ka tlas'a lebitso la khoebo NovoRapid (kantle ho eona, ho na le "insulin aspart" ea mekhahlelo e 'meli e fapaneng ka sebopeho sa eona.

Biphasic insulin

Biphasic insulin aspart e na le molao-motheo o tšoanang oa litlamorao tsa pharmacological 'meleng. Phapang ke hore e na le "insulin" e sebetsang ka nako e khutšoane le "hormone" ea protamine-insulin. Karolelano ea li-insulin tsena kalafong e ka tsela e latelang: 30% ke hormone e sebetsang kapele 'me 70% ke mofuta oa nako e telele.

Tšusumetso ea mantlha ea lithethefatsi e qala ka mokhoa o hlakileng hang ka mor'a ts'ebetso (nakong ea metsotso e 10), mme 70% ea lithethefatsi tse ling e theha phepelo ea insulin tlasa letlalo. E lokolloa butle butle 'me e nka khato ho fihlela lihora tse 24.

Ho boetse ho na le pheko eo ho eona ho kopantsoeng li-insulin tse khutšoane (aspart) le ultra-long-refu-mrefu (degludec). Lebitso la eona la khoebo ke Ryzodeg. Ho kenya sesebelisoa sena, joalo ka insulin e ngoe le e 'ngoe e kopaneng, o ka feela ka mokhoa o ikhethileng, oa fetola sebaka bakeng sa ente (ele ho qoba nts'etsopele ea lipodystrophy). Nako ea lithethefatsi karolong ea bobeli e fihla matsatsi a mabeli ho isa ho a mararo.

Haeba mokuli a hloka ho enta mefuta e fapaneng ea lihormone, mohlomong ho ka ba molemo hore a sebelise insulin aspart ea mekhahlelo e 'meli. Sena se fokotsa palo ea liente mme se thusa ho laola glycemia hantle. Empa ke setsebi sa endocrinologist feela se ka khethang pheko e nepahetseng ho latela sephetho sa tlhahlobo le tlhaiso-leseling ea tlhahlobo.

Melemo le likotsi

Insulin aspart (biphasic le single-phase) e fapana hanyane le insulin e tloaelehileng ea motho. Sebakeng se itseng, amino acid proline e nkeloa sebaka ke "aspartic acid" e tsejoang hape ka hore ke "aspartate". Sena se ntlafatsa feela boleng ba lihormone mme ha se ka tsela efe kapa efe e amang mamello ea eona, ts'ebetso le ho fokola haholo. Ka lebaka la phetoho ena, moriana ona o qala ho sebetsa ka potlako ho feta anelopele ea oona.

Bakeng sa likotsi tsa moriana o nang le mofuta ona oa insulin, hoa utloahala ho hlokomela, le ha o sa hlahe hangata, empa o ntse o le litlamorao tse mpe.

Ba ka itlhahisa ka mokhoa oa:

ho ruruha le ho hlonama sebakeng sa ente,
lipodystrophy,
lekhopho la letlalo
letlalo le omeletseng,
karabelo.

Contraindication

Contraindication mabapi le ts'ebeliso ea lithethefatsi ke ho hloka mamello ka bomong, ho kula le tsoekere e tlase ea mali (hypoglycemia). Hape ha ho na lithuto tse laoloang mabapi le ts'ebeliso ea insulin ena nakong ea kemolo le ho lactation. Liteko tsa liteko tsa phoofolo pele li bonts'itse hore litekong tse sa feteng tse khothalelitsoeng, moriana o ama mmele ka tsela e ts'oanang le insulin e tloaelehileng ea motho.

Ka nako e ts'oanang, ha tekanyetso e tsamaisitsoeng e ne e feta makhetlo a 4 ho8 liphoofolong, ho senyeheloa ke mpa ho bonngoe mehatong ea pele, nts'etsopele ea ts'ebetso e mpe ea tlhaho ho bana le mathata a ho hlaha mehatong e latelang ea boimana.

Ha ho tsejoe hore na sethethefatsi sena se fetela lebeseng, ka hona ha ho khothalletsoe hore basali ba anyese nakong ea kalafo. Haeba mokuli a hloka ho enta insulin nakong ea kemolo, kamehla moriana o khethoa ho bapisoa le melemo ho mme le likotsi tsa lesea.

E le molao, qalong ea bokhachane, tlhoko ea insulin e fokotseha haholo, 'me ka nako ea bobeli le ea boraro, moriana o ka hlokahala hape. Ka lefu la tsoekere la gestational, sesebelisoa sena ha se sebelisoe. Boemong bofe kapa bofe, eseng feela setsebi sa endocrinologist, empa hape le setsebi sa tlhokomelo ea basali se fanang ka thobalano se lokela ho fana ka kalafo e tšoanang ea lithethefatsi ho mosali oa moimana.

Mofuta ona oa li-hormone maemong a mangata o mamelloa hantle ke bakuli, 'me litlamorao tsa ts'ebeliso ea eona ha li hlahe hangata.

Mekhoa e mengata ea lithethefatsi e nang le mabitso a fapaneng a khoebo a thehiloeng ho eona e u lumella ho khetha maqhubu a mangata a jekeng bakeng sa mokuli ka mong ka bomong. Ha u phekola ka moriana ona, ho bohlokoa ho latela mokhoa o khothalletsoang ke ngaka mme o se lebale ka lijo, boikoetliso le bophelo bo botle.

Fomu ea tokollo

Ho emisoa d / le 100 IU / ml 3 ml No. 5

Tlhahisoleseling e leqepheng le o e shebileng e entsoe ka sepheo sa tlhahisoleseling feela 'me ha e phatlalatse mokhoa oa ho iphekola. Sesebelisoa se reretsoe ho tloaela litsebi tsa tlhokomelo ea bophelo bo botle ka tlhaiso-leseling e tlatselletsang mabapi le meriana e itseng, ka ho etsa joalo e eketse maemo a bona a bosebeletsi. Ts'ebeliso ea lithethefatsi "Insulin aspart mekhahlelo e 'meli" joang kapa joang e fana ka tumellano le setsebi, hammoho le litlhahiso tsa hae mabapi le mokhoa oa tšebeliso le litekanyetso tsa moriana o khethiloeng.

Insulin Aspart mekhahlelo e 'meli

Ho hlophisoa ho fumanoe ke theknoloji e ikhethang ea DNA e sebelisang mofuta oa Saccharomyces cerevisiae, moo amino acid proline e ileng ea nkeloa sebaka ka asiti ea asiti. Ts'ebeliso ea moriana ona e ka etsa phello ea lefu la tsoekere mellitus (DM), ea fokotsa monyetla oa mathata a itseng a lefu lena, kapa ea liehisa ho etsahala hoa bona ho batho ba nang le nalane ea nalane.

Sebopeho le mofuta oa tokollo

Ntho e sebetsang ea lithethefatsi (insulin Aspart) ke "insulin" e fetotsoeng ka liphatsa tsa lefutso. Moemeli oa hypoglycemic oa fumaneha e le tharollo ea mekhahlelo e 'meli (soluble insulin Aspart le likristale tsa protamine) bakeng sa tsamaiso e poteletseng le e kenang. Ntle le karolo e sebetsang, sebopeho sa moriana se kenyelletsa likarolo tse thusang. Bona tafole e ka tlase bakeng sa lintlha tse ling.

Sodium hydrogen phosphate dihydrate

Sodium hydroxide 2M

Hydrochloric acid 2M

Melemo ea pharmacological

Ntho e sebetsang ea lithethefatsi e sebelisana le li-receptor tse ikhethang tsa membrane ea cytoplasmic ea lisele, e etsa mofuta oa motsoako oa "insulin" o thusang ho hlophisa mefuta ea li-enzyme tse ngata tsa bohlokoa. Matla a sethethefatsi sena a bakoa ke ho eketseha ha tsoekere ke liseleng, le ho fokotseha hoa ts'ebetso ea glycogenic ea sebete.

Ho fetola amino acid boemong ba B28 ka asiti ea "acid" ho fokotsa tloaelo ea limolek'hule ho etsa karolo ea "hemogle" karolong e qhibilihang ea lithethefatsi, e boletsoeng mofuteng oa tlhaho oa lihormone. Ka lebaka lena, ho kenngoa ha Insulin Aspart ho tsoa mafura a subcutaneous ho etsahala ka potlako ho feta motho. Kamora ho kenngoa ha moriana, phello ea hypoglycemia e ba teng ka nako ea metsotso e 15- 20, e fihla hofihlella kamora lihora tse 1-3, mme kamora lihora tse 5-6, khatello ea tsoekere e khutlela boemong ba eona ba pele.

Matšoao a ho sebelisoa

Insulin Aspart e fuoe lefu la tsoekere le bolileng. Mofuteng oa 2 oa lefu la tsoekere, moriana o sebelisoa ha mokuli a lahlehetsoe ke kutloisiso ea insulin ka botlalo kapa ka karolo e itseng ho litho tsa hypoglycemic nakong ea phekolo. Ntle le moo, sehlahisoa sa pharmacological se khothalletsoa hore se sebelisoe ke batho bao, ntle le lefu le bakoang ke lefu la tsoekere ba nang le maemo a amanang le lefutso.

Litaelo tsa ho sebelisoa

Mokhoa oa ts'ebeliso ea lithethefatsi ke ente ea subcutaneous. Ho entoa ka mokokotlong ho thibetsoe. Li-infusions tsa insulin li behiloe ka seoelo haholo bakeng sa matšoao a ikhethang. Moriana o lokela ho tšeloa ka mpeng ea mpa, thipa kapa mokokotlo. U ka sebelisa mokelikeli oa insulin ea motho pele le ka mor'a lijo. Tekanyo ea lithethefatsi e baloa ka bonngoe ho mokuli ka mong.

Ka ts'ebetso ea renal kapa ea sebete e sa sebetseng, tlhoko ea li-hormone ea fokotseha, ha e ntse e eketseha ka mafu a tšoaetsanoang, e hlokang tokiso e lekanang ea insulin Aspart. Ho kenella ha sethethefatsi sena ho amana le lijo, ka hona ho loketse ho nahana ka tekanyo e phahameng ea ho hlaha ha phello ho bakuli ba nkang lithethefatsi tse fokotsang ho kenngoa ha lijo. Kamora ho lefella metabolism ea carbohydrate, bakuli ba ka ba le matšoao a bona a tloaelehileng a hypoglycemia, ba hloka ho tsamaisoa hang-hang ka tharollo ea tsoekere kapa tsoekere kahare.

Litaelo tse khethehileng

Litaelong tsa tšebeliso, ho tlaleha hore tekanyetso e sa lekaneng kapa tšitiso ea kalafo ea lefu la tsoekere e ka lebisa ho hyperglycemia, ketoacidosis. Ts'ebeliso ea Insulin Aspart maemong a mang e hloka keketseho ea palo ea liente tsa baemeli ba pele ba hypoglycemic. Nakong ea kalafo ea lefu la tsoekere le sethethefatsi sena, ho lokela ho ba hlokolosi ha u khanna makoloi le ha u etsa lintho tse ling tse kotsi tse hlokang ho tsepamisa mohopolo le ho potlakisa karabelo ea psychomotor.

Ho sebelisana le lithethefatsi

Insulin Aspart ha e lumellane ka meriana le tharollo ea lithethefatsi tse ling. Ketso ea sethethefatsi e ntlafatsoa ke lithethefatsi tsa molomo tsa hypoglycemic, inhibitors ea MAO, inhibitors ea ACE, anacrase ea carbonic, sulfonamides, li-anabolic steroid, tetracyclines, lithethefatsi tse nang le ethanol. Lithibela-mafu tsa molomo, li-thiazide diuretics, heparin, li-antidepressants tsa trousclic, morphine, nikotine li thibela phello ea hypoglycemic ea li-hormone tsa mekhahlelo e 'meli. Tlas'a tšusumetso ea li-salicylates le reserpine, ho eketseha le ho fokolisa ketso ea moriana ho ka bonoa.

Litla-morao le ho sebelisa overdose haholo

Ho latela litekolo, qalong ea kalafo le sehlahisoa seo ho buuoang ka sona, tlolo ea tlatsetso e ka etsahala hangata, eo boholo ba eona e bang ba nakoana. Mohlomong nts'etsopele ea methapo ea tikoloho ea lehae ka mokhoa oa hyperemia, ho hlohlona ha letlalo sebakeng sa ente, lekhopho, le ho ruruha. Maemong a sa tloaelehang, litla-morao tse akaretsang li bonoa: angioedema, ho theola khatello ea mali, tachycardia, ho hema ka thata. Khahlano le nalane ea ho fetela litekanyetso tsa Insulin Aspart, maemo a latelang a pathological a ka hlaha:

hypoglycemia,
cramps
hypoglycemic coma,
acute pain neuropathy,
ho sitisoa ke puo
khatello ea maikutlo
ho mpefala ha lefu la tsoekere,
ho fufuleloa ho eketsehileng.

Lipehelo tsa thekiso le polokelo

Botshelo ba bophelo ba sehlahisoa ke likhoeli tse 30 ho tloha ka letsatsi la tlhahiso. Insulin Aspart e tlameha ho sireletsoa ho pepesehela mocheso le khanya haholo. Boloka lihormone tse fetotsoeng gene ka mocheso oa 2-8ºC. Setlhare se rekisoa ka litlolong tsa litlhare feela ka taelo ea ngaka.

Ha ts'ebeliso ea lihormone tsa mekhahlelo e 'meli e sa fetoheng e sa khonehe ka lebaka la ho se mamellane ha likarolo tsa eona kapa tlhokahalo ea moriana o theko e tlase, lingaka li fana ka litlhare tse tšoanang le Insulin Aspart. Kajeno, moreki o fuoa khetho e kholo ea li-hypoglycemic agents, empa, ho khetha sena kapa hore setlhare, baetsi ba USA, Japan le Europe Bophirima ba lokela ho khethoa. Maemong a mangata, ho fanoa ka li-analogues tse latelang:

NovoRapid Flexpen,
NovoLog,
NovoRapid Khokahano.

Theko ea Insulin Aspart

Lits'enyehelo tse tloaelehileng tsa lithethefatsi likhoebong tsa litlama tsa marang-rang ke hoo e ka bang 1700-1800 p. Ka 3 ml ea tharollo ea hypoglycemic. Ka lebaka la hore phekolo ea lefu la tsoekere e nang le insulin e fetotsoeng liphatsa tsa lefutso e hloka litšenyehelo tse kholo tsa lichelete, e ke ke ea e-ba taba e kholo ho ela hloko lisebelisoa tse ikhethileng tsa inthanete, moo theko ea lithethefatsi e leng tlase haholo ho feta kamoo ho boletsoeng ka litlhare tsa meriana.

Olga, ea lilemo li 48. Ke sebelisitse Insulin Aspart ha ke fumana hore lipilisi tsa lefu la tsoekere li emisitse feela ho sebetsa. Tekanyetso ea letsatsi le letsatsi ea lithethefatsi e laetsoe ke ngaka. Ho latela litlhahiso tse fumanoeng, ke hlahisitse likarolo tse 5 tsa tharollo pele ho lijo tse ling le tse ling. Ka lebaka la moriana, ke ile ka khona ho fetolela maemo a tsoekere ka nako e khuts'oane.

Andrey ea lilemo tse 50. Ka lilemo tse 3 ke ne ke tšoeroe ke lefu la tsoekere. Lipilisi, lijo, mokhoa oa bophelo o mafolofolo ha oa ka oa thusa ho theola tsoekere e ngata maling, ka hona ke ile ka tlameha ho chencha kalafo ea lihormone. Ngaka e ile ea eletsa ho sebelisa Insulin Aspart. Ke ile ka kenya li-IU tse 20 tsa moriana letsatsi le leng le le leng bakeng sa khoeli, ka mor'a moo boemo boo bo neng bo tsitsa.

Elena, ea lilemo li 56 ke ntse ke sebelisa Insulin Aspart selemo se le seng mme, ke tlameha ho amohela, ke ikutloa hantle haholo. Pele ho sena, ke ile ka ba le bofokoli bo sa feleng ba bohloko ba mesifa. Hajoale ke kenya li-unit tsa 14 tsa moriana letsatsi lohle. Ka nako e ts'oanang, ke shebisisa liphetoho tsa bophelo ba ka bo tloaelehileng, motheong oa ka ke fetola litekanyetso tsa letsatsi le letsatsi tsa moriana.

Mabapi le sethethefatsi

E laetsoe ho fokotsa khatello ea dextrose ho plasma.

Ho theola tsoekere ho qala ka ho ntlafatsa ho monya ha eona ka linama. Lithethefatsi li theola sekhahla sa tlhahiso ea tsoekere ka har'a sebete mme li ntlafatsa ho kenella ha lisele.

Karolo e le 'ngoe e laetsoe bakuli ba nang le lefu la tsoekere la mofuta oa 1.

Aspartum biphasic insulin e boetse e fuoe mofuta oa lefu la tsoekere la 2, haeba ho e-na le ho hanyetsa li-antidiabetesic agents.

Ketso ea moemeli oa karolo e le 'ngoe e khuts'oane. E etsahala metsotso e 10-20 kamora kopo. Nako ea ho pepesetsoa ho fihlela lihora tse 5.

Ketso ea mekhahlelo e 'meli - ho fihlela letsatsi. Phello ea kalafo e etsahala kamora metsotso e 10, hobane e na le hormone ea ketso e khuts'oane le e bohareng.

Likarolo tsa ts'ebeliso

Insulin Bifaxicum le Aspart li tšoaelitsoe bakuli ba ka tlase ho lilemo tse 6. Boithuto mabapi le phello ea lithethefatsi 'meleng oa bana ha li e-so tšoaroe. Lingaka ha li tsebe hore na moriana o tla ama boemo ba ngoana ka kakaretso joang.

Re fana ka theolelo ho babali ba sebaka sa rona sa marang-rang!

Ho nka kalafo nakong ea lactation ha ho thibetsoe. Tšebeliso e lumelloa haeba kotsi e ka bang teng ho lesea e ka tlase ho molemo ho mme.

Ha e le bakuli ba tsofetseng, hoa hlokahala ho fetola tekanyetso. Liphetoho tse amanang le botsofe 'meleng li ka lebisa ho bophelo bo botle. Kaha ts'ebetso ea litho tsa ka hare e sitisoa, ts'ebetso ea moriana oa hypoglycemic e mpefatsa boemo.

Ho sebelisana le lithethefatsi tse ling

Mithethefatsi e fokotsang tsoekere e maling, e nooang ka molomo, e ntlafatsa mohato oa karolo e sebetsang. Lithethefatsi tse joalo ha li khothalletsoe. Hypoglycemia ea hlaha, boemo bo khetholloang ka ho fokotseha ha tsoekere e ka tlase ho litekanyetso tse tloaelehileng.

Li-steroid tsa Anabolic, Ketoconazole, Pyridoxine le lithethefatsi tse ling tse thehiloeng ho ethanol le tetracyclines, tse sebelisoang ka nako e le ngoe le meriana ena ea hypoglycemic, le tsona li baka phokotseho e matla ea tsoekere ea mali.

Mekhoa ea ho thibela pelehi ea molomo, heparin le li-antidepressants tse sebelisoang ho tsoekere ea lefu la tsoekere ho fokotsa matšoao a khatello e ka fokotsa litlamorao tsa lithethefatsi.