Aspinat ea lithethefatsi: litaelo tsa tšebeliso

Moriana o na le litlamorao tsa antipyretic, analgesic.

Mochine oa tšebetso oa Aspinat o ipapisitse le ts'ebetso ea ts'ebetso ea li-enzymes tsa cycloo oxygenase 1 le 2, tlasa ts'usumetso ea hore li-prostaglandins li entsoe (ka lebaka la lefu la bohloko le ho ruruha sebakeng sa ts'ebetso ea ho ruruha).

Ka ho fokotseha hoa boemo ba li-prostaglandins sebakeng sa thermoregulation bokong, mofufutso oa eketseha le leseli la likepe le ea eketseha, ka lebaka leo antipyretic phello. Phello ea li-analgesic e bakoa ke phello e bohareng le e potelletseng ea meriana.

Acetylsalicylic acid e thibela ho hlophisoa ha enzyme ea thromboxane A2 liseleng tsa mali, liplatelete, tse fokotsang thrombosis, khokahanyo ea liplatelete le ho ikopanya ha tsona. E fihlelletsoe antiplatelet athari e phehella beke ka mor'a tekanyetso e le 'ngoe ea moriana. Hoa hlokomeleha hore phello ena e phatlalatsoa haholo ho banna.

Ka kalafo e nang le acetylsalicylic acid, menyetla ea ho ba le mokhoa o sa tsitsang oa angina pectoris, infraction ea myocardial ea fokotseha, mme sekhahla sa lefu ho tsoa ho mafu a tsamaiso ea methapo ea pelo le fokotseha.

Aspinat ea lithethefatsi e sebelisoa hantle bakeng sa thibelo ea mantlha le ea bobeli ea phello ea myocardial, haholo ho banna ba baholo ho feta lilemo tse 40.

Tekanyetso ea letsatsi le letsatsi ea 6 mg e eketsa nako ea prothrombin le ho thibela synthesis prothrombin tsamaisong ea sebete. Ho bohlokoa ho ela hloko hore ha u ntse u nka asiti ea acetylsalicylic, kotsi ea ho tsoa mali le tse fapaneng hemorrhagic complication ka nako ya kalafo le ka mora ho kenella.

Aspinate e fokotsa khatello ea methapo ea tlhaho e amanang le vithamine K, 2, 7, 9 le 10. Moriana o matlafatsa ts'ebetso ea fibrinolytic ea plasma ea mali, e tsosa tšebetso ea ho chesa uric acid ho tsoa 'meleng ka bongata bo bonyenyane (ka lebaka la ho ts'oaroa ka mokhoa o sa tsitsang ka har'a litubu tsa sistimi ea renal).

Ka blockade ea cycloo oxygenase-1 ka mpeng ea gastric, ts'ebetso ea li-prostaglandins tsa gastroprotective (e sireletsang) ea fokotseha, e ka bakang ulceration ea lebota la gastric le nts'etsopele ea mali.

Phapang e nyarosang haholo ho mucosa ea gastric e hlahisoa ke mefuta e khethehileng ea acetylsalicylic acid, enteric-soluble le dosage form, tse kenyelletsang buffers.

Litokisetso tse ling tsa acetylsalicylic acid

Fomu ea tokollo

Matlapa (Aspinat, Aspinat Cardio, Aspinat Plus, Aspinat 300), matlapa a nang le matla (Aspinat, Aspinat C).

Aspinat: acetylsalicylic acid (100 mg kapa 500 mg).

Aspinat Cardio: acetylsalicylic acid (50 mg kapa 100 mg), baeti: MCC, starch 1500, aerosil (colloidal silicon dioxide), stearic acid, koahela enteric: ACRYL-IZ (kopolo ea methacotic acid e nang le ethyl acrylate 1: 1, titanium dioxide, talc, triethyl citrate, anhydrous colloidal silicon oxide, sodium bicarbonate, sodium lauryl sulfate), Copovidone, hydroxypropyl cellulose (Klucel).

Aspen 300: acetylsalicylic acid (300 mg), ente ea enteric.

Aspinat Plus: acetylsalicylic acid (500 mg), caffeine (50 mg).

Aspinat S: acetylsalicylic acid (400 mg), ascorbic acid (240 mg).

Aspinat:

Matlapa a 10 ka pakete ea contour bezjacheykovoy, 1 kapa 2 pakete ka lebokoseng la karete,
10 kapa 20 likhomphutha. ka sekotlolong sa polymer ka lebokoseng la karete,
Ho na le matlapa a 10 ka paketeng e nang le lithutsoana, lipampiri tse 1 kapa tse 2 ka lebokoseng
Matlapa a 12 a boreleli polelong ea polymer ka pokellong ea likarete.

Aspinat Cardio:

Li-pcs tse 10 ka har'a mekotla ea lithutsoana, 1, 2, 3, 5, lipakete tse 10 ka lebokoseng la karete.
10, 20, 30, 50 kapa 100 li-pcs. ka mokotleng oa polymer ka pokellong ea likarete.

Aspen 300:

Li-pcs tse 10 ka pakete ea contour bezjacheyakovoy, 1, 2, 3, 5 kapa 10 lipakete lebokoseng la karete,
10, 20, 30, 50 kapa 100 li-pcs. ka sekotlolong sa polymer ka lebokoseng la karete,
Li-pcs tse 10 ka har'a mekotla ea lithutsoana, 1, 2 kapa 10 mekotla e lebokoseng.

Aspinat Plus:

Li-pcs tse 10 ka har'a mekotla ea lithutsoana, 1, 2, 3 kapa 5 mekotla ea lebokose la karete,
10, 12, 15, 16, 20 kapa 30 li-pcs. ka mokotleng oa polymer ka pokellong ea likarete.

Aspinat S: Li-pcs tse 10 ka mokotleng oa polymer ka paketeng ea karete.

Ketso ea pharmacological

Monyetla oa sebopeho sa moriana o qhibilihang ha o bapisoa le asiti ea acetylsalicylic acid matlapeng ke ho monya ntho e sebetsang ka potlako le ka potlako.

Bohloko bo bobebe kapa bo bobebe ho batho ba baholo ba mefuta e fapaneng: hlooho ea hlooho (ho kenyelletsa le e amanang le lefu la ho itlopa joala), leino le bohloko, migraine, neuralgia, radicular radicular syndrome, mesifa le bohloko bo kopaneng, bohloko nakong ea ho ilela khoeli.
Keketseho ea mocheso oa 'mele mochesong le mafu a mang a tšoaetsanoang le a tšoaetsanoang (ho batho ba baholo le ho bana ba ka holimo ho lilemo tse 15).

Aspinat Cardio:

Thibelo ea infraction ea myocardial e mpe moo ho nang le lintho tse ka bang kotsi (mohlala, lefu la tsoekere, khatello ea maikutlo, khatello e matla ea mali, botena, ho tsuba, ho tsofala) le infraction ea myocardial,
Angina Khmer
thibelo ea stroke (ho kenyelletsa le ho bakuli ba nang le lefu la nakoana la mokokotlo),
Thibelo ea kotsi ea nakoana ea ts'ebetso ea methapo,
Thibelo ea thromboembolism kamora ho buuoa le ho kenella ka hare ho methapo ea methapo (e.g. coronary artery bypass grafting, carotid artery endarterectomy, arteriovenous shunting, carotid artery angioplasty),
thibelo ea "vein thrombosis" e tebileng le "thromboembolism" ea methapo ea methapo le makala a sona (mohlala, ka ho tsitsisa ha nako e telele ka lebaka la ts'ebetso e kholo ea ts'ebetso ea bongaka.

Contraindication

Hypersensitivity ho ASA, ba fumanang lithethefatsi le li-NSAID tse ling,
liso tsa bohloko tsa ka mpeng, ho tsoa mali ka mpeng,
hemorrhagic diathesis,
Asthma ea bronchial e susumetsoang ke ho nka li-salicylates le NSAIDs, Fernand Widal triad (motsoako oa asthma ea bronchial, phetoho e tsoang khafetsa ea nasal, sinuses ea paranasal le ho se mamellane ho ASA),
Motsoako o kopantsoeng le methotrexate ka tekanyo ea 15 mg ka beke kapa ho feta,
renal hepatichluleka,
boimana (I le III trimester),
lebone
lilemo tse 18.

Ka tlhokomelo:

gout
hyperuricemia
nalane ea liso tsa ka mpeng tse tsoang ka mpeng kapa ho tsoa mali ka mpeng, ho nyekeloa ke lefu la sebete le sebete, lefu la bronchial, mafu a sa foleng a phefumoloho, feberu ea feberu, phofo ea mpeng, litla-morao tsa meriana e meng.
II trimester ea ho ima,
hammoho le methotrexate ka lethal dose le ka tlase ho 15 mg ka beke,
khaello ea vithamine K le glucose-6-phosphate dehydrogenase.

Tekanyetso le tsamaiso

Ka hare, ho nwa metsi a mangata. Matlapa a sebetsang hantle a tlameha ho qhalwa pele ho 100-200 mg ea metsi a belisitsoeng ka mocheso oa kamore.

Tekanyetso le kemiso ea ho amoheloa li khethoa ke ngaka e eang, hobane mona ntho e 'ngoe le e' ngoe e latela lilemo tsa mokuli.

Ka bohloko bo boholo, o ka nka 400-800 mg ea acetylsalicylic acid makhetlo a 2-3 ka letsatsi (empa eseng ho feta 6 g ka letsatsi). Joaloka moemeli oa antiplatelet, ho sebelisoa litekanyetso tse nyane - 50, 100, 300 mg ea ntho e sebetsang. Bakeng sa feberu, ho khothalletsoa ho nka 0.5-1 g ea acetylsalicylic acid ka letsatsi (haeba ho hlokahala, lethal dose le ka eketsoa ho 3 g). Nako ea kalafo ha ea lokela ho feta matsatsi a 14.

Aspinat Cardio:

Setlhare sena se reretsoe tšebeliso ea nako e telele. Nako ea kalafo e khethoa ke ngaka e eang.

Thibelo maemong a belaetsang a hlobaetsang a myocardial infarction ke 100-200 mg / ka letsatsi (Letlapa la pele le tlameha ho hlafuna ho amoheloa ka potlako).
Thibelo ea infarction ea pele e mpe ea myocardial moo ho nang le mabaka a kotsi - 100 mg / ka letsatsi.
Thibelo ea infraction ea myocardial e sa khaotseng, angina e sa tsitsang, thibelo ea ho tšoaroa ke lefu la mokokotlo le koluoa ea nakoana, thibelo ea mathata a hlahang ka mor'a ho buuoa kapa lithuto tse hlaselang - 100 mg / ka letsatsi.
Thibelo ea "vein thrombosis" e tebileng le "thromboembolism" ea methapo ea methapo le makala a eona ke 100-200 mg / ka letsatsi.

Litla-morao

Litlamorao: urticaria, edema ea Quincke.
Ho tsoa ho sesole sa 'mele: liphetoho tsa anaphylactic.
Ho tsoa pampitšana ea ka mpeng: ho nyekeloa ke pelo, ho opeloa ke pelo, ho hlatsa, bohloko bo ka mpeng, liso tsa mucous tsa mucous tsa mpa le duodenum ho tsoa mali ka mokhoa o phethahetseng, ho tsoa mali ka mpeng, ho eketsa ts'ebetso ea li-enzyme tsa sebete.
Ho tsoa ts'ebetsong ea phefumoloho: bronchospasm.
Ho tsoa ho sistimi ea hemopoietic: ho tsoa mali ho eketsehileng, phokolo ea mali (ka seoelo).
Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: ho tsekela, tinnitus.

Bongata

U lokela ho ba hlokolosi ka botaoa ba maqheku mme haholoholo baneng ba banyenyane (tšebeliso e feteletseng ea tahi kapa ho tahoa ka phoso, hangata e fumanoang baneng ba banyenyane), e ka lebisang lefung.

Matšoao a bosholu ba litekanyetso tse boima: ho nyekeloa ke pelo, ho hlatsa, tinnitus, ho se utloe litsebeng, ho tsekela, pherekano.

Phekolo: fokotsa phokotso.

Matšoao a Thata a Ho Fetola Bolo: feberu, hyperventilation, ketoacidosis, alkalosis ea ho hema, komello, ho nyeleha ha pelo le ho hema, ho hloleha ha hypoglycemia.

Phekolo: Ho kena sepetlele hang-hang lefapheng le ikhethileng bakeng sa kalafo ea tšohanyetso - lefu la sefuba, boikemisetso ba tekano ea acid-alkaline le alkaline diuresis, hemodialysis, ho hlahisoa ha tharollo, ho ts'oaroa ha khabone e sebetsitsoeng, kalafo ea matšoao.

Ha o etsa dialis ea alkaline, ho hlokahala ho fihlela boleng ba pH lipakeng tsa 7.5 le 8. Fors ea alkaline e qobelloang e lokela ho etsoa ha khatello ea li-salicylates ka plasma e feta 500 mg / l (3,6 mmol / l) ho batho ba baholo le 300 mg / l (2, 2 mmol / l) - baneng.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea ASA e ntlafatsa ketso ea lithethefatsi tse latelang:

methotrexate - ka lebaka la phokotseho ea clearance renal le ho falla ha eona ho tsoa puisanong le liprotheine,
heparin le anticoagulants e sa tobang - ka lebaka la ts'ebetso ea liplatelese e sa sebetseng le ho fallisoa ha li-anticoagulants tse sa tobang ho tsoa puisanong le liprotheine,
thrombolytic le antiplatelet (ticlopidine) lithethefatsi,
digoxin - ka lebaka la ho fokotseha ha popo ea eona ea renal,
hypoglycemic agents (insulin le sulfonylurea derivatives) - ka lebaka la thepa ea ASC ka boeona e noang tekanyetso e kholo le ho tlosoa ha liphihlelo tsa sulfonylurea puisanong le liprotheine,
valproic acid - ka lebaka la phallo ea eona ho tsoa puisanong le liprotheine.

Tlatsetso e eketsoa ha o ntse o nka ASA ka joala.

ASA e fokolisa phello ea lithethefatsi tsa uricosuric (benzbromarone) ka lebaka la phapanyetsano ea tubular ea uric acid.

Ka ho ntlafatsa ho felisoa ha li-salicylates, li-corticosteroids tsa systemic li fokolisa matla a tsona.

Bokhachane le pelehi

Ts'ebeliso ea litekanyetso tse kholo tsa li-salicylates kahara trimester ea pele ea moimana e amana le khafetsa khafetsa ea bofokoli ba nts'etsopele ea fetal (karohano e arohaneng, bofokoli ba pelo).

Ka trimester ea bobeli ea boimana, li-salicylates li ka fuoa feela ka tlhahlobo e tiileng ea kotsi le molemo.

Khoeling ea ho qetela ea kemaro, li-salicylate ka tekanyetso e phahameng (tse fetang 300 mg / ka letsatsi) li baka tšitiso ea pelehi, ho koaloa kapele ha ductus arteriosus ka popelong, ho eketseha ha mali ho 'm'a le lesea, le tsamaiso hanghang pele ho hlaha li ka baka ho ruruha ha methapo pele ho nako.

Ho khethoa ha li-salicylate ka har'a trimester ea ho qetela ea moimana ho khahlanong le.

Li-salicylates le li-metabolites tsa tsona ka tekanyo e nyane li fetela lebeseng la matsoele. Ho ja ka mokhoa o sa sebetseng oa li-salicylates nakong ea lebone ho sa tsamaeeng le nts'etsopele ea maikutlo a mabe ka ho ngoana mme ha ho hloke ho felisoa ha letsoele. Leha ho le joalo, ka ts'ebeliso ea nako e telele ea lithethefatsi kapa ho khethoa ha lethal dose le phahameng, ho anyesa ho lokela ho emisoa hanghang.

Litaelo tse khethehileng

Aspen e lokela ho sebelisoa feela kamora ho khethoa ha ngaka.

Moriana o ka kenya letsoho ho tsoa mali, hammoho le ho eketsa nako ea ho ilela khoeli. Acetylsalicylic acid e eketsa kotsi ea ho tsoa mali haeba ho ka etsoa opereishene.

Aspinate ha e sebelisoe bongoaneng ka lebaka la kotsi ea Reye syndrome.

Matla a ho khanna koloi / mekhoa ha e bonoe.

Matšoao a ho sebelisoa

Aspen e laetsoe ho emisa febrile syndrome, e tsamaeang le mafu a mangata a tšoaetsanoang le a tšoaetsanoang.

Hajoale, acetylsalicylic acid ha e sebelisetsoe ho phekola pericarditisramatiki rheumatic chorea, rheumatism le mafu a tšoaetsanoang myocarditis.

Litaelo tsa tšebeliso Aspinat e khothaletsa ho fana ka moriana ho fumana litlamorao (ka tekanyetso ea ho fihlela ho 300 mg ka letsatsi) bakeng sa bakuli ba nang le angina e sa tsitsang, lefu la pelo, lefutso le phetoa hangata, le methapo ea pelo ea maiketsetso. coronary balloon angioplasty.

Setlhare se sebelisetsoa ho imolla bohloko ba mefuta e fapaneng: lumbago, arthralgia, hlooho e bohloko (ho kenyelletsa le bohloko ba migraine bo bakoang ke matšoao a ho ikhula), neuralgia, leino, algomenorrhea, lefu la radicular syndrome, bohloko ba mesifa.

Ho allergology le phekolo ea meriana immunology, Aspinat e khothalletsoa ho sebelisoa ho eketsa tekanyetso ho nts'etsapele mamello e sa khaotseng (ho hanyetsa) ho lithethefatsi tse seng khahlanong le ts'oaetso tsa bakuli ho bakuli ba nang le "Aspirin triad" le "Aspirin asthma".

Litlamorao

Phekolo e ka baka ho nyekeloa ke pelo, lets'ollo, Reye syndrome .

Acetylsalicylic acid e ka baka "asthin ea" aspirin "le" asthma ea "aspirin" ka lebaka la sebopeho sa mochine oa hapten.

Phekolo ea nako e telele e tsamaisana le ho opeloa ke hlooho, ho senyeha ha pono, ho ruruha le ho ruruha ha liso tsa methapo ea methapo ea lijo, tinnitus, ho hlatsa, ho tsekela, nephrotic syndromepapillary necrosis, bronchospasm, ho senyeha ha molumo oa kutlo, hypocoagulation, interstitial nephritis, hypercalcemia, peleho ea azotemia, ho ruruha, litekanyetso tsa li-enzyme tsa sebete, matšoao a matla a ho hloleha ha pelo ho sa feleng, meningitis ea aseptic.

Aspinat, litaelo tsa tšebeliso (Mokhoa le litekanyetso)

Matlapa a Soluble Aspinat a khothalletsoa hore a qhaloe ka metsi a fokolang pele a sebelisoa: makhetlo a 2-3-8 ka letsatsi ho 400-800 mg (empa eseng ho feta ligrama tse 6).

Acetylsalicylic acid ho litekanyetso tsa 50-70-100-300-325 mg e sebelisetsoa ho fihlela antiplatelet athari, ka tekanyetso ea ho feta 325 mg - ho fihlella analgesic le anti-inflammatory.

A rheumatism a hlobaetsang khetha 100 mg ka kilo e le 1 ka letsatsi bakeng sa litekanyetso tse 5-6.

Ka bohloko bo boholo le syndromes ea febrile batho ba baholo ba fuoe ligrama tse 0,5-1 ka letsatsi (bakeng sa litekanyetso tse 3).

Nako ea kalafo ea Aspinat ha ea lokela ho feta matsatsi a 14.

Mefuta ea matla a moriana o lokela ho qhibiliha ka 100-200 ml ea metsi pele a kenella, haholo-holo ka mor'a lijo.

Nako ea kalafo e ka fapana ho tloha tekong e le 'ngoe ho isa ho likhoeli tse' maloa.

Bakeng sa bakuli ba nang le lefu la myocardial infarction, moriana o fuoa meriana ea thibelo ea bobeli ka tekanyo ea 40-325 mg ka letsatsi (litekanyetso tse tloaelehileng ke 160 mg).

Ho ntlafatsa litšobotsi tsa rheological tsa mali ho fihlelleha ka ho sebelisa ligrama tse 0,15-0.25 tsa acetylsalicylic acid ka letsatsi (kalafo e etselitsoe likhoeli tse 'maloa).

Ka tekanyetso ea 300-325 mg ka letsatsi, lithethefatsi li thibela bongata ba lisele tsa mali.

Hothromboembolism tšimoloho ea kokoana-hloko, e nang le likotsi tse matla tsa "cerebrovascular" ho banna, ho fanoa ka 325 mg ka letsatsi (palo ea lithethefatsi e nyoloha butle ho isa gram e le 'ngoe ka letsatsi).

Thibelo ea ho khutla hape e fumaneha ka ho nka 125-300 mg ka letsatsi.

Bakeng sa thibelo ea occlusion ea aortic shunt le thrombosis ea eona, ho khothalletsoa hore moriana o sebelisoe ka tube e ikhethileng ea gastric e kenngoeng kahare ka tekanyetso ea 325 mg ka mong le e mong lihora tse 7. Ho feta moo, ho buelloa ka molomo bakeng sa acetylsalicylic acid makhetlo a mararo ka letsatsi ka tekanyo ea 325 mg (hangata ho feta, dipyridamole e boetse e beoa bakeng sa beke).

Tšebelisano

Aspinate e eketsa chefo ea heparin, sulfonamides, li-hypoglycemic agents, narcotic analgesics, reserpine, Co-trimoxazole, anticoagulants e sa tobang, methotrexate, li-inhibitors tsa liplatelese, li-thrombolytics.

Setlhare se khona ho fokotsa katleho ea lithethefatsi tsa diuretic (furosemide, Veroshpiron), lithethefatsi tse felisang kalafo.

Monyetla oa ho tsoa mali ka mpeng o eketseha haholo ha o ntse o sebelisa lithethefatsi tse nang le ethanol, glucocorticosteroids.

Hematotoxicity ea Aspartate e eketseha le lithethefatsi tsa myelotoxic

Meriana ea antacid ho mpefatsa ho monya ha acetylsalicylic acid.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Matlapa a qhibilihang: kahare, a kile a qhibiliha ka metsi a fokolang, 400-800 mg makhetlo a 2-3 ka letsatsi (ha a sa feteng 6 g). A rheumatism e mpe - 100 mg / kg / letsatsi ka tekanyetso ea 5-6.

Matlapa a nang le ASA ho litekanyetso tse kaholimo ho 325 mg (400-500 mg) a etselitsoe ho sebelisoa e le sethethefatsi sa analgesic le se thibelang mafu, litekanyetso tsa 50-75-100-300-325 mg ho batho ba baholo, haholo-holo e le lithethefatsi tsa antiplatelet.

Ka hare, ka lefu la febrile le bohloko, batho ba baholo - 0.5-1 g / letsatsi (ho fihlela ho 3 g), ba arotsoe ka litekanyetso tse 3. Nako ea kalafo ha ea lokela ho feta libeke tse 2.

Matlapa a atlehileng a qhibilihile ka 100-200 ml ea metsi mme a nkuoa ka molomo, kamora ho ja, tekanyetso e le 'ngoe - 0,25-1 g, e nkuoa makhetlo a 3-4 ka letsatsi. Nako ea kalafo - ho tloha tekong e le 'ngoe ho ea ho likhoeli tse ngata.

Ho ntlafatsa thepa ea rheological ea mali - 0,15-0.25 g / letsatsi ka likhoeli tse 'maloa.

Ka infraction ea myocardial, hammoho le thibelo ea bobeli ho bakuli kamora lefu la myocardial infarction, 40-325 mg hang ka letsatsi (hangata 160 mg). Joalo ka inhibitor ea platelet aggregation - 300-325 mg / letsatsi ka nako e telele. Ka mathata a matla a "cerebrovascular" ho banna, "cerebral thromboembolism" - 325 mg / letsatsi ka keketseho ea butle-butle ho isa ho 1 g / letsatsi, bakeng sa ts'ireletso ea ho khutla - 125-300 mg / letsatsi. Bakeng sa thibelo ea "thrombosis" kapa "occlusion" ea aortic shunt, ka makhetlo a 325 mg, lihora tse ling le tse ling tse 7 ka mokokotlong oa gastric ea gastric, ebe 325 mg ka molomo makhetlo a 3 ka letsatsi (hangata e kopantsoe le dipyridamole, e hlakotsoeng kamora beke, e ntse e tsoela pele kalafo e telele le ASA).

Ka rheumatism e sebetsang e ne e laetsoe (hajoale e sa laeloe) ka tekanyetso ea letsatsi le letsatsi ea 5-8 g bakeng sa batho ba baholo le 100-125 mg / kg bakeng sa bacha (lilemo tse 15-18), khafetsa ea tšebeliso ke makhetlo a 4-5 ka letsatsi. Kamora libeke tse 1-2 tsa kalafo, bana ba fokotseha tekanyetso ho ea ho 60-70 mg / kg / ka letsatsi, kalafo ea batho ba baholo e ntse e tsoela pele ka tekanyetso e le 'ngoe, nako ea kalafo e fihla ho libeke tse 6. Ho hlakola ho etsoa butle butle ka nako ea libeke tse 1-2.