Protaphane® HM (Protaphane® HM)

Hypoglycemic agent, "insulin" e sebetsang ka nako e telele.
Ho itokisetsa: PROTAFAN® NM
Ntho e sebetsang ea lithethefatsi: isophane insulin emisoa batho
ATX Encoding: A10AC01
KFG: Insulin ea Nako e Bohareng
Reg. palo: P No. 014722/01
Letsatsi la ho ngolisa: 04/20/07
Mong'a reg. acc: NOVO NORDISK A / S

Fomu ea tokollo Protafan nm, sephutheloana sa lithethefatsi le sebopeho.

Ho emisoa bakeng sa tsamaiso ea sc ea 'mala o mosoeu, ha e kopana, e theha sehlahla se tšoeu ebile e le' mala o makatsang kapa o batlang o se na 'mala, ha o hlohlelletsa, o lokela ho khutlisoa hape.

1 ml
isofan insulin (boenjiniere ba lefutso la motho)
100 IU *

* 1 IU e tsamaisana le 35 μg ea insulin ea motho ea metsi.

10 ml - libotlolo tsa khalase e se nang mebala (1) - mekotla ea karete.

TLHOKOMELISO EA TLHALOSO EA SEBETSO.
Tlhahisoleseling eohle e fanoeng e hlahisoa feela bakeng sa ho tloaelana le moriana, o lokela ho buisana le ngaka ka monyetla oa ho e sebelisa.

Ts'ebetso ea Pharmacological Protafan nm

Moemeli oa hypoglycemic, insulin ea mahareng e fumanoang ke boenjiniere ba liphatsa tsa lefutso, e tšoana hantle le insulin.

Ho sebelisana le li-receptor tse ikhethang ho membrane e ka ntle ea lisele, ho etsa motsoako oa "insulin" receptor. Ka ho eketsa motsoako oa cAMP (liseleng tsa mafura le lisele tsa sebete) kapa ho kenella ka ho toba ka seleng (mesifa), motsoako oa "insulin" o hlohlelletsa lits'ebetso tse kahare ho eona, ho kenyeletsa synthetise ea li-enzyme tse 'maloa tsa bohlokoa (ho kenyeletsa hexokinase, pyruvate kinase, glycogen synthetase).

Ho fokotseha ha tekanyo ea tsoekere maling ho bakoa ke keketseho ea lipalangoang tsa eona tse ka hare, ho eketsoa ho eketsehileng le ho ts'oaroa ke lisele, ho hlohlelletsoa hoa lipoisis, glycogenogeneis, synthesis ea protheine, le ho fokotseha ha sekhahla sa tlhahiso ea tsoekere ke sebete (ho fokotseha ha ho phatloha ha glycogen).

Pharmacokinetics ea lithethefatsi.

Ho kenella le ho qala hoa ts'ebetso ho latela tsela ea tsamaiso (sc kapa intramuscularly), sebaka (mpa, thipa, buttocks) le bongata ba ente, bongata ba insulin. E ajoa ka mokhoa o sa lekanang liseleng, ha e kenelle ka sehokelong sa placental le ka lebese la matsoele. E senngoa ke insulinase, haholo-holo ka har'a sebete le liphio. E hloekisoa ke liphio (30-80%).

Tekanyetso le tsela ea tsamaiso ea moriana.

Kenya s / c, makhetlo a 1-2 / letsatsi, metsotso e 30-45 pele ho lijo tsa hoseng. Sebaka sa ente se lokela ho fetoloa nako le nako. Maemong a ikhethang, ho ka hlahisoa tlhahiso ea / m.

Ho / ho kenyelletsa insulin ea nako e mahareng ha e lumelloe.

Litekanyetso li beoa ka bonngoe, ho latela se ka hare ho glucose maling le moroto, litšoaneleho tsa lefu lena.

Side effect of Protafan nm:

Reaction ka lebaka la phello ea metabolism ea carbohydrate: hypoglycemia (pallor ea letlalo, mofufutso o eketsehileng, palpitations, ho thothomela, tlala, ho ruruha, paresthesia molomong, hlooho). Hypoglycemia e matla e ka lebisa ho hola ha mesifa ea hypoglycemic.

Boitšoaro bo kulang: ka seoelo - lekhopho la letlalo, edema ea Quincke, maemong a mang - ho ts'oaroa ha anaphylactic.

Boitšoaro ba lehae: hyperemia, ho ruruha, ho hlohlona, ​​ka tšebeliso ea nako e telele - lipodystrophy.

Tse ling: edema, liphoso tsa nakoana tsa ho hlaka (hangata qalong ea phekolo).

Sebelisa nakong ea bokhachane le pelehi.

Nakong ea kemolo, ho hlokahala hore ho nahane ka ho fokotseha ha tlhoko ea insulin ho trimester ea pele kapa keketseho ea li-trimesters tsa bobeli le tsa boraro. Nakong ea ha lesea le hang kamora ho hlaha, litlhoko tsa insulin li ka theoha haholo.

Nakong ea lactation, ho lekola letsatsi le letsatsi ho hlokahala likhoeli tse 'maloa (ho fihlela tlhoko ea insulin e tsitsitse).

Litaelo tse ikhethang bakeng sa ts'ebeliso ea Protafan nm.

Ka hlokolosi, lethal dose la lithethefatsi le khethoa ho bakuli ba nang le mathata a amanang le "c" a kalafo ea methapo ho latela mofuta oa ischemic le mefuta e matla ea lefu la pelo la ischemic.
Tlhokahalo ea insulin e ka fetoha maemong a latelang: ha o fetohela ho mofuta o mong oa insulin, ha o fetola lijo, lets'ollo, ho hlatsa, ha o fetola bonyata ba tloaelo ea ho ikoetlisa 'meleng, mafu a liphio, sebete, pituitary, tšoelesa ea qoqotho.
Ho hlokahala hore ho lokisoe lethalamo la insulin bakeng la maloetse a tšoaetsanoang, ho se sebetse ha qoqotho ea qoqotho, lefu la Addison, hypopituitarism, ho se atlehe ha renal, le lefu la tsoekere ho bakuli ba lilemo tse fetang 65.

Phetisetso ea mokuli ho insulin ea batho e lokela ho lula e lokafatsoa ka nepo le ho etsoa feela ka taolo ea ngaka.

Lisosa tsa hypoglycemia e ka ba: ho sebelisa insulin haholo, ho khutlisetsa lithethefatsi, ho tlōla lijo, ho hlatsa, lets'ollo, khatello ea mmele, mafu a fokotsang tlhoko ea insulin (mafu a liphio tse matla le a sebete, hammoho le hypofunction ea adrenal cortex, pituitary kapa gland ea tšoelesa). (mohlala, letlalo le ka mpeng, mahetleng, serope) hammoho le ho sebelisana le lithethefatsi tse ling. Ho a khonahala ho fokotsa khatello ea "glucose" e ngata maling ha o fetisetsa mokuli ho tsoa ho insulin ea motho.

Mokuli o lokela ho tsebisoa ka matšoao a lefu la hypoglycemic, ka matšoao a pele a ho ba le lefu la tsoekere le ka tlhoko ea ho tsebisa ngaka ka liphetoho tsohle maemong a hae.

Tabeng ea hypoglycemia, haeba mokuli a le hlokolosi, o fuoa dextrose ka hare, s / c, i / m kapa iv e kentsoeng glucagon kapa iv solution ea hyperonic dextrose. Ka nts'etsopele ea komello ea hypoglycemic, 20-40 ml (ho fihlela ho 100 ml) ea tharollo ea dextrose 40% e kenngoa ka har'a molatsoana ho fihlela mokuli a akheha.

Bakuli ba nang le lefu la tsoekere ba ka emisa hypoglycemia eo ba e utloang ka ho ja tsoekere kapa lijo tse nang le lik'habohaedreite tse ngata (bakuli ba khothalletsoa hore ka mehla ba be le bonyane 20 g ea tsoekere).

Ho mamella joala ho bakuli ba fumanang insulin hoa fokotseha.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Tšekamelo ea ho ba le hypoglycemia e ka fokolisa bokhoni ba bakuli ba ho khanna makoloi le ho sebetsa ka mekhoa.

Tšebelisano ea Protafan nm le lithethefatsi tse ling.

Phello ea hypoglycemic e ntlafatsoa ke li-sulfonamides (ho kenyelletsa le li-activine tsa hypoglycemic tsa molomo, sherfanilamides), li-inhibitors tsa MAO (ho kenyeletsoa furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, li-inhibitors tsa ACE, li-NSAIDs (ho kenyeletsa le salicylides), anabolic (ho kenyelletsa stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, litokisetso tsa lithium, pyridoxine, quinidine, quinine, chloro, chinine.

Glucagon, somatropin, GCS, lithibela-pelehi tsa molomo, li-estrogens, thiazide le "loop" diuretics, calcium chblockers, li-hormone tsa qoqotho, heparin, sulfin pyrazone, audiathomimetics, danazole, tricyclic antidepressants, calcium chloride, moron, fokotsa hypoglycemic. nicotine, phenytoin, epinephrine, histamine H1 receptor blockers.

Beta-blockers, reserpine, octreotide, pentamidine ka bobeli li ka ntlafatsa le ho fokotsa phello ea hypoglycemic ea insulin.

Ka meriana ha a lumellane le tharollo le lithethefatsi tse ling.

Tlhophiso ea Nosological (ICD-10)

Protafan ® HM Penfill ®

Clinical Pharmacology

Phello e ba teng kamora lihora tse 1.5 kamora ho tsamaisoa ha sc, e fihla hofihlella kamora lihora tse 4 ho isa ho tse mashome a mabeli. , hammoho le li-insulin tse sebetsang ka potlako.

Tekanyetso le tsamaiso

Protafan ® HM Penfill ®

P / c. Setlhare sena se etselitsoe tsamaiso e tlisoang ke subcutaneous. Litšisinyeho tsa insulin li ke ke tsa kenngoa / ka.

Tekanyo ea lithethefatsi e khethoa ka bonngoe, ho nahanela litlhoko tsa mokuli. Ka tloaelo, litlhoko tsa insulin li pakeng tsa 0,3 le 1 IU / kg / letsatsi. Tlhokahalo ea insulin ea letsatsi le letsatsi e ka ba e phahameng ho bakuli ba hanyetsang insulin (mohlala, nakong ea ho kena bohlankaneng kapa ho bakuli ba nang le botenya), le tlase ho bakuli ba nang le tlhahiso ea insulin ea insulin.

Protafan ® NM e ka sebelisoa ho monotherapy hammoho le insulin.

Protafan ® NM hangata e tsamaisoa ka mokhoa o potelletseng ka thipa. Haeba sena se loketse, joale liente li ka boela tsa etsoa ka leboteng la ka mpeng la mpa, karolong ea gluteal kapa karolong ea mesifa e senyehileng ea mahetla. Ka kenyelletso ea moriana ka serope, ho kenngoa butle butle ho feta ha ho kenngoa libakeng tse ling. Haeba ente e etsoa lesakeng le lelelele la letlalo, kotsi ea ts'ebetso ea ts'ebetso ea methapo ka phoso e fokotsoa.

Lenaliti le lokela ho lula le le ka tlasa letlalo bonyane metsotsoana e tšeletseng, e leng le netefatsang lethal dose. Hoa hlokahala hore kamehla o fetole sebaka sa ente kahare ho sebaka sa anatomical ho thibela nts'etsopele ea lipodystrophy.

Protafan ® NM penfill ® e etselitsoe hore e sebelisoe ka lits'ebetso tsa ente ea Novo Nordisk insulin le li-needle tsa NovoFine ® kapa NovoTvist ®. Litlhahiso tse qaqileng tsa ts'ebeliso le ts'ebeliso ea moriana li lokela ho bonoa.

Mafu a khahlang, haholo a tšoaetsanoang le feberu, hangata a eketsa tlhoko ea mmele ea insulin. Phetoho ea mori le eona e ka hlokahala haeba mokuli a e-na le mafu a a amanang le a liphio, sebete, ho senyeha hoa sesole sa adrenal, gland. Tlhokahalo ea tokiso ea tekanyetso e ka hlaha le ha o fetola ts'ebetso ea 'mele kapa lijo tse tloaelehileng tsa mokuli. Ho ka hlokahala phetoho ea tekanyetso ha u fetisetsa mokuli ho tsoa mofuteng o mong oa insulin ho ea ho e 'ngoe

Bongata

Matšoao Nts'etsopele ea hypoglycemia (mofufutso o batang, palpitations, ho thothomela, tlala, ho ruruha, ho teneha, pallor, hlooho, ho otsela, ho hloka motsamao, ho bua le ho fokola hoa pono, khatello ea maikutlo). Hypoglycemia e matla e ka lebisa ho senyeha hoa nakoana kapa ho sa feleng hoa tšebetso ea boko, ho akheha le lefu.

Phekolo: tharollo ea tsoekere kapa tsoekere ka hare (haeba mokuli a hlokahetse), s / c, i / m kapa iv - glucagon kapa iv - glucose.

Litheko makaleng a litlama a litsobotsi tsa meriana Moscow

Tlhahisoleseling e fanoeng ka litheko tsa lithethefatsi ha se tlhahiso ea ho rekisa kapa ho reka thepa.
Tlhahisoleseling ena e reretsoe feela ho bapisa litheko makafatseng a stationary a sebetsang ho latela Article 55 ea Molao oa Federal "On Circulation of Medicines" ea 12,04.2010 N 61-ФЗ.

Sokolla foromo le sebopeho

Sebopeho sa litekanyetso - ho emisoa bakeng sa tsamaiso e potolohileng: e tšoeu, ha e eme e le mokelikeli o se nang mebala le sepheo se sesoeu, e ts'oaroa ka ho tsosa (10 ml ka libotlolong tsa khalase tse se nang mebala, botlolo e le 'ngoe ka pakete ea karete).

Ntho e sebetsang: insulin-isophan (boenjiniere ba lefutso la motho), ka botlolong e le 'ngoe - likarolo tsa 100 tsa Machabeng, tse lumellanang le 3.5 mg ea insulin ea motho ea metsi.

Lisebelisoa tse ling: protamine sulfate, phenol, metacresol, sodium hydrogen phosphate dihydrate, glycerol, chloride ea zinc, sodium hydroxide le / kapa hydrochloric acid, metsi bakeng sa ente.

Tekanyetso le tsamaiso

Protafan NM e tsamaisoa ka mokhoa o ikhethileng.

Tekanyetso e khethoa ka bonngoe ho latela litlhoko tsa mokuli ka bomong, hangata ke 0,3-1 IU / kg ka letsatsi. Tlhokahalo e ka ba tlase ho bakuli ba nang le masalela a tlhahiso ea insulin kapa a holimo ho bakuli ba hanyetsang insulin (mohlala, boteng le botšehali).

Protafan NM e ka sebelisoa e le sethethefatsi se le seng hape hammoho le insulin e potlakileng kapa e khutšoane.

Maemong moo ho nang le tlhokahalo ea kalafo ea insulin e matla, ho emisoa ho ka sebelisoa e le basal insulin (liente ka shoalane le / kapa hoseng) hammoho le insulin e khutšoane kapa e potlakileng (ente ea eona e lokela ho kenngoa lijong). Haeba ho ka etsahala ho fihlela taolo e phethahetseng ea glycemia, joale mathata a lefu la tsoekere a hlaha hamorao, mabapi le eo motho a lokelang ho loanela ho ntlafatsa taolo ea metabolic, ka hloko a laole boemo ba tsoekere maling.

Protafan HM hangata e tsamaisoa ka mokhoa o potelletseng sebakeng sa thipa. U ka kenya kahare ho mpa ea mpa ea mpa, karolong e lutlang ea mahetla, kapa karolong ea gluteal. Leha ho le joalo, ketsahalong ea pele, ho ananeloa ha moriana ho potlakileng ho tsebahala.

Ho fokotsa kotsi ea ente ea kotsi ea "intramuscular" ka phoso, ente e lokela ho etsoa mokokotlong oa letlalo. Ho thibela nts'etsopele ea lipodystrophy, ho kgothaletsoa ho fetola sebaka sa ente setsing sa anatomical.

Ho bakuli ba nang le bothata ba ho ruruha ha renal le hepatic, ho hlokahala hore insulin e fokotsehe, ka hona, ho hlokahala tokiso ea lethal dose ea Protafan NM.

Ho emisoa ho ka tsamaisoa feela ka li-insulin tsa insulin ka sekhahla se u lumellang ho lekanya tekanyetso e hlokahalang maemong a ts'ebetso. Lipolao ke tsa ts'ebeliso ea motho feela.

Pele o sebelisa Protafan NM:

• Lekola sephutheloana mme o netefatse hore na mofuta o nepahetseng oa insulin o khethiloe,
• Lumella lithethefatsi hore li futhumale le mocheso oa kamoreng ebe u kopanya ho emisoa,
• Ho bolaea meriana e thibelang rabara.

Lithethefatsi ha lia lumelloa ho sebelisoa maemong a latelang:

• Ka lipompong tsa insulin
• Bokaholimo ba ts'ireletso ea botlolo ha bo na kapa bo lokoloha
• Setlhare se ne se bolokiloe ka nepo kapa se letse leqhoa,
• Kamora ho kopanya, moriana ha o qale (o sa fetohe o le lerootho ebile o mosoeu).

Mokhoa oa ho enta ha o sebelisa Protafan NM feela:

• Hlohlelletsa ho emisoa, ho etsa sena, lalela botlolo lipakeng tsa liatla (ho li futhumatsa ho mocheso oa kamore),
• Ho hula moea sering ka tekanyo e lekanang le tekanyetso e hlokahalang ea insulin,
• Kenya moea moea vial ka ho phunya sethala sa rabara le ka ho tobetsa sehokelo sa syringe,
• Ho fetola botlolo o shebile holimo, fumana tekanyetso e nepahetseng ea insulin,
• Tlosa nale ka lehare ebe o tlosa moea seriting,
• Lekola lethal dose le nepahetseng
• Kenya hang-hang.

Mokhoa oa ente ha o sebelisa Protafan NM hammoho le insulin e sebetsanang le nako e khuts'oane:

• Tsosa ho emisoa (joalo ka ha ho hlalositsoe kaholimo),
• Bokella moea ka har'a seratsoana ka bophahamo bo lekanang le tekanyetso ea Protafan NM, e kenye ka botlolong e loketseng u tlose nale ena.
• Ho hula moea ka har'a sirapo ho bophahamo bo lekanang le lethalinyana la insulin (ICD) e khutšoane, kenya ka botlolong e loketseng.
• Phetisa botlolo o thulametse ebe o letsa lethal dose ea ICD,
• Tsamaea nale, tlosa moea syringe 'me u hlahlobe ho nepahala ha lethal dose le bokelletsoeng,
• Kenya nale ka botlolo ka botlolong ka Protafan NM, phetisetsa botlolo holimo o letse lethathamo leo u le batlang.
• Tlosa nale ka leqaqailaneng le moeeng ho tsoa syringe, lekola ho nepahala ha tekanyo e bokelletsoeng,
• Hang-hang kenya motsoako oa insulin ea nako e telele le e liehang ho sebetsa.

Insulin e lokela ho lula e bokelloa ka tatellano e hlalositsoeng ka holimo!

Melao ea tsamaiso ea lithethefatsi:

• Ka menoana e 'meli, penta letlalo le lesakeng, kenya nale ka setsing sa eona ka sekala se ka bang 45 ° le ho kenya insulin tlasa letlalo.
• Siea nale ka tlasa letlalo bonyane metsotsoana e tšeletseng ho etsa bonnete ba hore lethal dose e fanoa ka botlalo.

Litlamorao

Litla-morao nakong ea kalafo e nang le Protafan NM hangata li itšetleha ka tekanyetso mme li bakoa ke ketsahalo ea meriana ea insulin. Karabelo e atileng haholo ke hypoglycemia, e atisang ho hlaha ha ho e-ba le tekanyo e kholo ea tekanyetso ea insulin mabapi le tlhokahalo ea eona. Hypoglycemia e matla e ka tsamaisana le ho akheha le / kapa ho tsitsipana, ho lebisang ts'ebetsong ea kelello e sa sebetseng esita le lefu.

Litlamorao tse ka bang teng:

Ho tloha lehlakoreng la sesole sa 'mele: khafetsa (> 1/1000, 5 11111 Litekanyetso: 5 - 1 vouta

Bokhachane le pelehi

Ha ho na lithibelo ho ts'ebeliso ea insulin nakong ea kemolo, hobane insulin ha e tšele mekoallo ea placental.

Ka bobeli hypoglycemia le hyperglycemia, tse ka ntlafatsang maemong a kalafo e khethiloeng ka mokhoa o loketseng, li eketsa kotsi ea ho senyeha ha lesea le lefu la fetal. Bakhachane ba nang le lefu la tsoekere ba lokela ho betoa leihlo nakong eohle ea bokhachane ba bona, ho hlokahala hore ba be le taolo e ntlafatsang ea khatello ea tsoekere ea mali, likhothaletso tse tšoanang li sebetsa le ho basali ba rerileng ho ima.

Tlhokahalo ea insulin hangata e fokotseha ho "trimester" ea pele ea bokhachane mme butle-butle e eketseha ho li-trimesters tsa bobeli le tsa boraro.

Kamora ho tsoala ngoana, tlhoko ea insulin, joalo ka molao, e khutlela kapele boemong bo shebiloeng pele ho kemaro.

Hape ha ho na lithibelo ho ts'ebeliso ea lithethefatsi Protafan® NM nakong ea ho anyesa. Ho etsa kalafo ea insulin ho basali nakong ea matsoele ha ho kotsi ho lesea. Leha ho le joalo, ho ka hlokahala hore o fetole mofuta oa moriana oa lithethefatsi Protafan® NM le / kapa oa lijo.

Ho sebelisana le lithethefatsi tse ling

Hona le lithethefatsi tse 'maloa tse amang tlhokahalo ea insulin.

Hypoglycemic phello ea ka insulin ntlafatsa molomo mahlahana hypoglycemic, monoamine dihydrobenzophenanthridine inhibitors, angiotensin fetola inhibitors potlakisang tsebetso ea lik'hemik'hale, k'habone inhibitors anhydrase, khetha beta-blockers, bromocriptine, sulfonamides, anabolic steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithethefatsi lithium salicylates .

Phello ea hypoglycemic ea insulin e fokotsoa ke lithibela-pelehi tsa molomo, li-glucocorticosteroids, lihormone tsa qoqotho, li-thiazide diuretics, heparin, li-antidepressants tsa li-trioclic, li-sympathomimetics, li-hormone tsa kholo (somatropin), danazol, clonidine, li-blockchain tse khutšoanyane tsa calcium, difenin, diazoxide.

Beta-blockers li ka koala matšoao a hypoglycemia le ho liehisa ho hlaphoheloa ka mor'a hypoglycemia.

Octreotide / lanreotide ka bobeli li ka eketsa le ho fokotsa tlhoko ea mmele ea insulin.

Joala bo ka ntlafatsa kapa ba theola phello ea hypoglycemic ea insulin. Ho se lumellane

Ho ts'oaroa ha insulin ha hoa lokela ho eketsoa ka tharollo ea infusion.

Likarolo tsa ts'ebeliso

Tekanyetso e sa lekaneng kapa ho khaotsa ho phekoloa, haholo-holo ka lefu la tsoekere la mofuta oa 1, ho ka lebisa nts'etsopele ea hyperglycemia.

E le molao, matšoao a pele a hyperglycemia a hlaha butle butle, ho feta lihora tse 'maloa kapa matsatsi. Matšoao a hyperglycemia a kenyelletsa lenyora, ho ruruha ho eketsehileng, ho nyekeloa, ho hlatsa, ho otsela, redness le ho omella ha letlalo, molomo o omileng, ho felloa ke takatso ea lijo le ponahalo ea monko oa acetone moeeng o tsoang. Ntle le kalafo e nepahetseng, hyperglycemia ho bakuli ba lefu la tsoekere la mofuta oa 1 e ka lebisa ho lefu la tsoekere la ketoacidosis, boemo bo ka bolaeang.

Hypoglycemia e ka hlaha haeba ho fanoa ka tekanyetso e phahameng haholo ea insulin mabapi le litlhoko tsa mokuli.

Ho tlōla lijo kapa ho ikoetlisa ka thata ka tsela e sa reroang ho ka lebisa ho hypoglycemia.

Kamora ho lefa tefo ea metabolism ea carbohydrate, ka mohlala, nakong ea kalafo ea insulin e matlafatsang, matšoao a bakuli a tloaelehileng ho bona a ka fetoha - ba tlang pele ho hypoglycemia, eo bakuli ba lokelang ho tsebisoa ka eona. Matšoao a tloaelehileng a temoso a ka nyamela ka nako e telele ea lefu la tsoekere.

Ho fetisetsoa ha bakuli ho mofuta o mong oa insulin kapa insulin ea moetsi e mong ho lokela ho etsoa feela ka tlhokomelo ea bongaka. Haeba u fetola mahloriso, moetsi, mofuta, mofuta (insulin ea motho, analog ea insulin ea motho) le / kapa mokhoa oa ho etsa, ho ka hlokahala hore u fetole tekanyetso ea insulin. Bakuli ba ntseng ba phekoloa le Protafan® NM ba ka hloka phetoho ea tekanyetso kapa keketseho ea khafetsa ea ente e bapisoa le litokisetso tsa insulin tse neng li sebelisoa pele. Haeba ho hlokahala hore ho etsoe phetoho ea lethalinyana ha ho fetisetsoa bakuli kalafo le Protafan® NM, sena se ka etsoa ka tlhahiso ea tekanyetso ea pele kapa libekeng tsa pele kapa likhoeli tsa kalafo.

Joalo ka litokisetso tse ling tsa insulin, methapo e ka hlaha setsing sa ente, se bonahatsoang ke bohloko, bokhubelu, hives, ho ruruha, hematoma, ho ruruha le ho hlohlona. Ho fetolela sebaka sa ente khafetsa sebakeng se le seng sa anatomical ho tla thusa ho fokotsa matšoao kapa ho thibela nts'etsopele ea liphetoho tsena. Reaction hangata e nyamela kamora matsatsi a seng makae ho isa ho libeke tse 'maloa. Maemong a sa tloaelehang, ho felisoa ha Protafan® NM ho ka hlokahala ka lebaka la karabelo setsing sa ente.

Pele a tsamaea ka phetoho ea libaka, mokuli o lokela ho buisana le ngaka ea hae, kaha ho fetola nako ho bolela hore mokuli o lokela ho ja le ho fana ka insulin ka nako e fapaneng. Ho ts'oaroa ha insulin ho ke ke ha sebelisoa lipompong tsa insulin.

Ts'ebeliso e tšoanang ea lithethefatsi tsa sehlopha sa thiazolidinedione le litokisetso tsa insulin

Litaba tsa ho ntlafala ha lefu la pelo le sa foleng li tlalehiloe kalafong ea bakuli ba nang le thiazolidinediones hammoho le litokisetso tsa insulin, haholoholo haeba bakuli ba joalo ba na le mabaka a tlisoang ke ho hola ho sa feleng ha pelo. Ntlha ena e lokela ho ananeloa ha ho fanoa ka phekolo ea ho kopanya le thiazolidinediones le litokisetso tsa insulin ho bakuli. Ka ho khethoa ha mofuta o joalo oa phekolo, ho bohlokoa ho etsa tlhahlobo ea bongaka ea bakuli ho bona matšoao le matšoao a ho se atlehe ha pelo, boima ba mmele le boteng ba edema. Haeba matšoao a ho hloleha ha pelo a mpefala ho bakuli, kalafo e nang le thiazolidinediones e tlameha ho khaotsa.

Tšusumetso ho bokhoni ba ho khanna makoloi le ho sebetsa ka mekhoa

Bokhoni ba bakuli ba ho tsepamisa mohopolo le sekhahla sa karabelo se ka senyeha nakong ea hypoglycemia, e ka bang kotsi maemong ao bokhoni bona bo hlokahalang haholo (mohlala, ha o khanna makoloi kapa o sebetsa ka mechine le metjeko). Bakuli ba lokela ho eletsoa ho nka mehato ea ho thibela nts'etsopele ea hypoglycemia ha u ntse u khanna. Sena ke sa bohlokoa haholo ho bakuli ba se nang matšoao a tlisoang ke ho ba le hypoglycemia kapa ba nang le liketsahalo tsa khafetsa tsa hypoglycemia. Maemong ana, ho tšoaneleha ho tšoaneleha ha ho khanna le ho etsa mosebetsi o joalo.

Maemo a polokelo

Boloka ka mocheso oa 2 ° C ho isa ho 8 ° C (sehatsetsing), empa eseng haufi le sehatsetsi. Se ke oa chesa.

Boloka botlolo ka lebokoseng la likarete ho li sireletsa.

Bakeng sa botlolo e butsoeng: se ke oa boloka ka sehatsetsing. Boloka ka mocheso o sa feteng 25 ° C bakeng sa libeke tse 6.

Protafan® NM e lokela ho sireletsoa mochesong o matla le khanya. Qoba hole le bana.