Oxodoline (Oxodoline)

Lebitso la machabeng:Oxodoline

Sebopeho le mofuta oa tokollo

Lipilisi Letlapa le le leng le na le 50 mg ea chlortalidone.

Ka thipa e mengoapo ea matlapa a 50. E kentsoe ka lebokoseng la karete.

Sehlopha sa tliliniki le meriana

Sehlopha sa Pharmacotherapeutic

Tlhakolo ea khato ea lithethefatsi Oxodolin

Thiazide-joaloka diuretic, e na le phello e tšoarellang. E senya ts'ebetso ea ho kopanya hape ha ion ea sodium, chlorine le metsi a lekanang liphoofolong tsa liphio tsa distal. Ntle le moo, e eketsa excretion ea potasiamo, magnesium, bicarbonate ions ho tloha 'meleng, ho lieha ho hlahisa li-uric acid, ion ea calcium. E bua ka diuretics tsa mahareng sebetsa hantle. Phello ea diuretic e qala kamora lihora tse peli, e fihla hofeta kamora lihora tse 12 mme e nka lihora tse 72. E baka phokotseho ea khatello e phahameng ea mali. Tlatsetso ea antihypertensive e fetoha butle butle, e fihla hofeta kamora libeke tse 2 ho isa ho tse peli. kamora ho qala kalafo. Ntle le moo, chlortalidone e baka ho fokotseha ha polyuria ho bakuli ba nang le lefu la tsoekere, le ha ts'ebetso ea ts'ebetso ea eona e sa hlakisoa.

Mofumahali

Kamora ho tsamaisoa ka molomo, chlortalidone e ananeloa ho tsoa ho tšilo ea lijo. Ho ba le botenya ha ho tsitse. E tlameha ho etsa lisele tse khubelu tsa mali ho isa tekanyong e phahameng, hobane liprotheine tsa plasma ha li hlahisoe haholo.

T 1/2 nako e telele, lihora tse 40-60.

E pepisoa ka mokhoa o sa fetoheng ka moroto.

Ho bakuli ba tsofetseng, ho pepeseha ho fokotsoa butle, ha ho bapisoa le bakuli ba lilemo tse tlase le tse bohareng, ho amoheloa ha ho fetohe.

II sethala CHF, khatello ea methapo ea methapo ea mali, lefu la sebete la mokokotlo le lefu la methapo ea pelo, nephrosis, nephritis, gestosis ea morao-rao (nephropathy, edema, eclampsia), ho bolokoa hoa metsi mokokotlong oa lefu la premenstrual, lefu la tsoekere, dysproteinemic edema, botenya.

Contraindication

Hypersensitivity (ho kenyelletsa le sulfonamide derivatives), hypokalemia, a hlobaetsang le renal ho hloleha (anuria), hepatic coma, a hlobaetsang le hepatitis, lefu la tsoekere le lefu la tsoekere. Ho sitoa ha letsoalo le / kapa ho se sebetse hantle ha mokokotlo, ho hlaseloa ke lintho tse ngata, asthma ea bronchial, SLE.

Mokhoa oa litekanyetso le mokhoa oa ts'ebeliso Oxodoline

Kenya ka bonngoe. Ka khatello ea mali ea methapo - 25 mg 1 nako / letsatsi. Haeba ho hlokahala, lethalinyana le ka eketsoa ho 50-100 mg / ka letsatsi. Ha ba fihletse phello, ba fetola pheko ea tlhokomelo ka tekanyetso e sebetsang e tlase. Ka edematous syndrome, tekanyo ea 50-100 mg e sebelisoa nako e le 'ngoe / letsatsi, haeba ho hlokahala, ho fihlela ho 200 mg, ka mor'a ho fihlela sephetho, ba fetohela kalafo ea tlhokomelo.

Litlamorao

Ho tsoa ts'ebetsong ea tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho sokela, ho felloa ke takatso ea lijo.

Ho tsoa ho tsamaiso ea methapo e bohareng le tsamaiso ea methapo ea kutlo: hlooho, bofokoli, paresthesia, ho tsekela tse ka khonehang.

Ho tsoa ho chelete-electrolyte esele: hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypercalcemia lia khonahala.

Ka lehlakoreng la metabolism: hyperuricemia, hyperglycemia.

Ho tsoa ho sheropoietic system: ka seoelo - thrombocytopenia, leukopenia.

Boitšoaro ba letlalo: makhopho a letlalo a ka etsahala.

Bokhachane le pelehi

E kenella ka har'a sethopo sa placental. Nakong ea kemolo e hanyetsanoa ka khatello ea mali ea methapo. Maemong a mang, tšebeliso e ka khonahala tlasa matšoao a thata feela ka tekanyetso e sebetsang mme ha phaello e lebelletsoeng ea kalafo ho mme e feta kotsi e ka bang teng ho lesea.

Chlortalidone e pepesoa lebeseng la matsoele. Haeba ho hlokahala, sebelisa nakong ea lebone, ho anyesa ho lokela ho emisoe.

Sebelisa bakeng sa ts'ebetso ea sebete e senyehileng Ho na le ts'ebetso e matla ea ho senyeha ha sebete. Sebelisa ka masene maemong a ts'ebetso ea ho senyeha ha renal e sa sebetseng.

Sebelisa ho bakuli ba tsofetseng

Sebelisa ka tlhokomeliso ho batho ba baholo.

Litaelo tse khethehileng tsa ho amoheloa Oxodoline

Nakong ea phekolo, ho hlokahala nako le nako ho khetholla li-electrolyte tsa mali, haholo-holo ho bakuli ba nkang litokisetso tsa digitalis. Ha ho kgothaletswe ho fana ka phepo e thata haholo e se nang letsoai ho bakuli. Haeba ho na le matšoao a hypokalemia (myasthenia gravis, pherekano ea morethetho) kapa haeba bakuli ba na le monyetla o eketsehileng oa ho lahleheloa ke K + (ka ho hlatsa, lets'ollo, khaello ea phepo e nepahetseng, cirrhosis, hyperaldosteronism, kalafo ea ACTH, GCS), kalafo e khutlisang ka lithethefatsi tsa K + e bontšoa. Ho bakuli ba nang le hyperlipidemia, lipids tsa serum li lokela ho lula li beiloe leihlo (haeba khatello ea bona e eketseha, kalafo e lokela ho khaotsa). Ka thiazide diuretics, ho eketseha ha SLE ho hlokometsoe. Le ha liketsahalo tse joalo li e-so fumanoe ka chlortalidone, tlhokomeliso e lokela ho sebelisoa ha e fana ka taelo ho bakuli ba nang le SLE.

Tšebelisano le Meriana e meng

Ka tšebeliso e tšoanang le corticosteroids, amphotericin B, carbenoxolone, kotsi ea ho ba le hypokalemia e matla ea eketseha.

Ka tšebeliso e le 'ngoe le li-NSAIDs, ho fokotseha hoa litlamorao le li-antihypertensive tsa chlortalidone hoa khoneha.

Ka tšebeliso e le 'ngoe ea litokisetso tsa dijithale, ho ka etsahala ho eketsa kotsi ea litlamorao tsa litokisetso tsa digitalis ka lebaka la hypokalemia ka lebaka la ketso ea chlortalidone.

Ka tšebeliso e tšoanang ea lithium carbonate, khatello ea lithium maling a mali le menyetla ea ho eketseha ha li-lithium.

Tšebeliso ea lithethefatsi Oxodolin feela joalo ka ha u laetsoe ke ngaka, tlhaloso e fanoa bakeng sa ho buuoa!

Ke matšoao afe a ho utloisisa hore motho o ba le bothata ba kelello?

Mofumahali

Kamora ho tsamaisoa ka molomo, chlortalidone e ananeloa ho tsoa ho tšilo ea lijo. Ho ba le botenya ha ho tsitse. E tlameha ho etsa lisele tse khubelu tsa mali ho isa tekanyong e phahameng, hobane liprotheine tsa plasma ha li hlahisoe haholo.

T 1/2 nako e telele, lihora tse 40-60.

E pepisoa ka mokhoa o sa fetoheng ka moroto.

Ho bakuli ba tsofetseng, ho pepeseha ho fokotsoa butle, ha ho bapisoa le bakuli ba lilemo tse tlase le tse bohareng, ho amoheloa ha ho fetohe.

Matšoao a lithethefatsi

Litla-morao

Ho tsoa ho ts'ilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho sokela, ho lahleheloa ke takatso ea lijo hoa khoneha.

Ho tloha lehlakoreng la methapo ea methapo e bohareng le tsamaiso ea methapo ea methapo: hlooho, bofokoli, paresthesia, ho tsekela ho ka khoneha.

Ho tsoa ho tekanyo ea electrolyte ea metsi: hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypercalcemia lia khoneha.

Ho tloha ka lehlakoreng la metabolism: hyperuricemia e ka khonehang, hyperglycemia.

Ho tsoa kemisong ea hemopoietic: ka seoelo - thrombocytopenia, leukopenia.

Boitšoaro ba letlalo: Makhopho a letlalo a ka etsahala.

Bokhachane le pelehi

E kenella ka har'a sethopo sa placental. Nakong ea kemolo e hanyetsanoa ka khatello ea mali ea methapo. Maemong a mang, tšebeliso e ka khonahala tlasa matšoao a thata feela ka tekanyetso e sebetsang mme ha phaello e lebelletsoeng ea kalafo ho mme e feta kotsi e ka bang teng ho lesea.

Chlortalidone e pepesoa lebeseng la matsoele. Haeba ho hlokahala, sebelisa nakong ea lebone, ho anyesa ho lokela ho emisoe.

Litaelo tse khethehileng

E sebelisoa ka hloko ho bakuli ba nang le lefu la tsoekere mellitus, le gout, atherosulinosis e matla ea methapo ea methapo le methapo, ts'ebetso ea ho senyeha ha renal, ho batho ba tsofetseng.

Ts'ebetsong ea kalafo, ho hlokahala ho laola setšoantšo sa mali, karolo ea electrolyte ea mali, boemo ba uric acid, tsoekere maling.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Chlortalidone, haholo-holo qalong ea kalafo, e kanna ea sitisa bokhoni ba ho khanna makoloi le ho sebetsa mochine.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang le corticosteroids, amphotericin B, carbenoxolone, kotsi ea ho ba le hypokalemia e matla ea eketseha.

Ka tšebeliso e le 'ngoe le li-NSAIDs, ho fokotseha hoa litlamorao le li-antihypertensive tsa chlortalidone hoa khoneha.

Ka tšebeliso e le 'ngoe ea litokisetso tsa dijithale, ho ka etsahala ho eketsa kotsi ea litlamorao tsa litokisetso tsa digitalis ka lebaka la hypokalemia ka lebaka la ketso ea chlortalidone.

Ka tšebeliso e tšoanang ea lithium carbonate, khatello ea lithium maling a mali le menyetla ea ho eketseha ha li-lithium.

Sebopeho le mofuta oa tokollo

ka paketeng ea blc ea li-pcs tse 10., ka paketeng ea likarete tse 5 kapa ka khalase e lefifi ea khalase ea li-pcs tse 50.

Pharadodynamics

E thibela ts'ebetso e ntlafatsang ea ion ea sodium (Na +), haholo-holo karolong e poteletseng ea leople ea Henle), e eketsa tlhahiso ea li-ion tsa sodium (Na +), chlorine ions (Cl -) le metsi. Lintho tse hlahisoang ke potasiamo ions (K +) le ion ea magnesium (Mg 2+) ka liphio li eketseha, ha tlhahiso ea calcium ions (Ca 2+) e fokotseha.

Ho baka ho fokotseha hanyane ha khatello ea mali, ho teba ha phello ea hypotensive butle-butle ho eketseha mme ho bonahala ka botlalo libeke tse 2 ka mor'a ho qala ha kalafo.

Qalong ea phekolo, e baka ho fokotseha ho hoholo ha molumo oa mokelikeli oa extracellular, BCC, le bophahamo ba motsotso oa mali, leha ho le joalo, kamora ho sebelisoa libeke tse 'maloa, matšoao ana a khutlela boemong bo haufi le ba mantlha.

Joalo ka thiazide diuretics, e baka ho fokotseha ha polyuria ho bakuli ba nang le lefu la tsoekere la renal.

Ho qala ketso ke lihora tse 2-5 kamora ho kenella, phello e kholo ke kamora lihora tse 12, nako ea ts'ebetso ke matsatsi a 2-3.

Contraindication

hypersensitivity (ho kenyeletsoa le sulfonamide derivatives),

mefuta e tsoetseng pele e tebileng ea nephrosis le nephritis e fokotsehang ka sekhahla sa mokhoa oa ho feto-fetoha ha glomerular,

ho hlohlona ha bohloko haholo ka lebaka la anuria,

hepatic coma, hepatitis e hlobaetsang,

lefu la tsoekere (liforomo tse matla),

tsitsipano moeling oa motlakase oa motlakase,

bana ba ka tlase ho lilemo tse 18 (ho sebetsa hantle le polokeho e sa thehoeng).

renal le / kapa ho hloleha ha sebete,

systema lupus erythematosus,

Litlamorao

Ho tsoa ts'ebetsong ea tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, ho opeloa ke mpa, ho ruruha kapa lets'ollo, intrahepatic cholestasis, jaundice, pancreatitis.

Ho tsoa tsamaisong ea methapo: kizunguzungu, paresthesia, asthenia (mokhathala o sa tloaelehang kapa bofokoli), ho ferekanya kelello, ho hloka thahasello.

Ho tsoa linthong tsa kutlo: ho senyeha hoa pono (ho kenyelletsa xanthopsia).

Karolong ea mali le litho tse bopang mali: thrombocytopenia, leukopenia, agranulocytosis, eosinophilia, anemia ea aplasiki.

Ho tsoa ho tsamaiso ea pelo le pelo: orthostatic hypotension (e ka eketseha tlasa tšusumetso ea ethanol, anesthetics, lithethefatsi tse thetsang), arrhythmia (ka lebaka la hypokalemia).

Matšoao a laboratori: hypokalemia, hyponatremia (ho kenyelletsa le matšoao a methapo - ho nyekeloa hoa pelo), hypomagnesemia, hypochloremic alkalosis, hypercalcemia, hyperuricemia (gout), hyperglycemia, glucosuria, hyperlipidemia.

Litla-morao: urticaria, photosensitivity.

Tse ling: mesifa ea mesifa, potency e fokotsehile.

Tšebelisano

E eketsa khatello ea methapo ea lithium ion (Li +) maling (maemong ao ha Li + e baka polyuria, e ka ba le phello ea antidiuretic), ka hona, e eketsa kotsi ea ho tahoa ka lithethefatsi tsa Li +.

E ntlafatsa phello ea li-relaxar tsa mesifa ea curariform le lithethefatsi tsa antihypertgency (ho kenyelletsa le guanethidine, methyldopa, beta-blockers, vasodilators, BKK), MAO inhibitors.

Ha e ntse e nka pelo glycosides, e ka mpefatsa pelo le ho feta ka lebaka la tahi ea digitalis.

Matla a hypokalemic a lithethefatsi a ntlafatsoa le tsamaiso e kopanetsoeng ea GCS, amphotericin, carbenoxolone.

NSAIDs e fokolisa phello ea hypotensive le diuretic tsa lithethefatsi.

Khahlano le semelo sa tšebeliso ea chlortalidone, tokiso (ho eketsoa kapa ho fokotseha) ka tekanyetso ea "insulin" kapa keketseho ea tekanyetso ea litlhare tsa hypoglycemic e ka hlokahala.

Tekanyetso le tsamaiso

Ka hare (hangata hoseng, pele ho lijo tsa hoseng). Litlhoko li khethoa ka bonngoe, ho latela botebo le mofuta oa lefu lena le phello e fumanoeng. Ka kalafo ea nako e telele, ho khothaletsoa ho fana ka lethal dose e sebetsang e tlase haholo ho boloka phello e nepahetseng (haholo-holo ho bakuli ba tsofetseng).

Ka tekanyo e fokolang ea khatello ea mali - 50 mg hang ka letsatsi makhetlo a 3 ka beke.

Ka lefu la edematous: Tekanyetso ea pele ke 100 mg letsatsi le leng le le leng (litekanyetso tse kaholimo ho 100 mg hangata ha li hlahise keketseho), tekanyetso ea tlhokomelo ke 100-120 mg ka letsatsi makhetlo a 3 ka beke.

Ka mofuta oa renal oa lefu la tsoekere: Tekanyetso ea pele ke 100 mg makhetlo a 2 ka letsatsi, tekanyetso ea tlhokomelo ke 50 mg ka letsatsi.

Bongata

Matšoao ho tsekela, ho nyekeloa, ho otsela, hypovolemia, ho fokotseha ho feteletseng ha khatello ea mali, arrhythmia, ho tsitsipana.

Phekolo: gastric lavage, ho ts'oaroa ha mashala a entsoeng ka matla, phekolo ea matšoao (ho kenyelletsa le infusion ea tharollo ea letsoai ho khutlisetsa chelete ea electrolyte).

Ketso ea pharmacological

E kenya letsoho ho hatelleng ha reabsorption e sebetsang ea sodium ion, haholo-holo liphoofolong tsa reisal tse ntseng li eketseha, e eketsa tlhahiso ea chlorine, sodium le ion ea metsi. The excretion ea calcium ions ka liphio ea fokotseha, 'me ion ea magnesium le potasiamo e eketseha.

E baka khatello e tlase ea khatello. Botebo ba phello e matlafatsang bo eketseha butle butle, 'me bo iponahatsa ka botlalo libeke tse peli ho isa ho tse' ne ka mor'a ho qala kalafo.

E baka ho fokotseha ho matla ha bophahamo ba mali ba motsotso, BCC le bophahamo ba mokelikeli oa extracellular, empa phello ena e bonoa feela qalong ea kalafo. Kamora libeke tse 'maloa, matšoao a nka boleng haufi le a mantlha.

Joalo ka thiazide diuretics, e thusa ho fokotsa polyuria ho bakuli ba nang le lefu la tsoekere la renal.

Moriana o qala ho sebetsa lihora tse peli ho isa ho tse 'ne ka mor'a ho tsamaisoa ka molomo. Phello e phahameng e fihlella ka mor'a lihora tse leshome le metso e 'meli. Nako ea ts'ebetso e fapana ho tloha matsatsi a mabeli ho isa ho a mararo.

Ho senya - karolo ea 50 lekholong ka lihora tse 2.6. Bioavailability ke karolo ea 64 lekholong. Plasma e tlamang protheine ke karolo ea 76 lekholong. Kamora ho sebelisa moriana ka tekanyo ea 100 kapa 50 mg, Cmax e fihlella kamora lihora tse 12 mme ke 16.5 le 9.4 mmol / L, ka ho latellana.

Nako ea bophelo bo felisang e fapana ho tloha lihora tse 40 ho isa ho tse 50. E hloekisoa e sa fetoloe ke liphio. E feta lebese la matsoele. E ka ba le ho bokellana ho sa foleng ha renal.

Matšoao a ho sebelisoa

Oxodoline e etselitsoe:

• jade, nephrosis,
• khatello ea kelello ea methapo
• sebete cirrhosis ka khatello ea mali portal,
• lengolo la pelo le sa foleng la pelo,
• edysproteinemic edema,
• mofuta oa renal oa lefu la tsoekere,
• botenya.

Sebopeho, foromo ea tokollo

E fumaneha ka mokhoa oa matlapa a masoeu. Ho lumelloa tinge e mosehla. Matlapa a beoa ka har'a linkhoana tsa khalase tse lefifi kapa ka matlapa, ebe li kenngoa mabokoseng a karete.

Motsoako o sebetsang oa oxodoline ke chlortalidone. Lisebelisoa tse thusang li kenyeletsa: starch ea litapole, tsoekere ea lebese (lactose), calcium stearic acid (calcium stearate), polyvinylpyrrolidone e nang le boima ba molek'hule.

Lipehelo, linako tsa polokelo

Sebakeng se phodileng, se sirelelitsoeng leseli.

Kajeno ho thata ho fumana Oxodolin libakeng tsa meriana tsa Russia, ka hona ho ke ke ha khonahala ho fihlela liqeto mabapi le litšenyehelo tsa lithethefatsi.

Lifeme tsa lithethefatsi tsa Seukraine Oksodolin ha li hlokomele.

Lithethefatsi tse latelang ke lihokahanyi tsa lithethefatsi: Gigroton, Urandil, Edemdal, Hydronal, Isoren, Oradil, Renon, Urofinil, Apochlortalidon, Chlortalidone, Chlorphthalidolone, Famolin, Igroton, Natriuran, Phthalamidine, Saluretin, Zambezil.

Ho ipapisitsoe le litlhahlobo, motho a ka ahlola ts'ebetso e phahameng ea Oxodoline. Bakuli ba nang le khatello ea maikutlo ba mamella meriana hantle.

Tlhahlobo ea lingaka tse laetseng moriana oa tsona lithethefatsi li tiisa ntlha ena.

Boitšoaro bo sa rateheng bo etsahala hangata, bo bonahatsoa ke ho hloka botsitso ho fokolang. Ho ea ka lingaka, Oxodolin e loketse kalafo ea nako e telele.

Lekola tlhahlobo ea 'nete ea lithethefatsi qetellong ea sengoloa. Abelana maikutlo a hau ka Oxodoline haeba o kile oa e nka kapa oa e laela.

Melemo ea pharmacological

Pharadodynamics
Moemeli oa diuretic. E thibela ts'ebetso e ntlafatsang ea ion ea sodium (Na +), haholo-holo karolong e poteletseng ea leleople ea Henle), e eketsa tlhahiso ea Na, "chlorine ions" le metsi. Lintho tse hlahisoang ke potasiamo ions (K +) le ion ea magnesium (Mg 2+) ka liphio li eketseha, ha tlhahiso ea calcium ions (Ca 2+) e fokotseha. E baka ho fokotseha hanyane ha khatello ea mali (BP), ho teba ha phello ea hypotensive butle butle ho eketseha mme ho bonahala ka botlalo libeke tse 2 ka mor'a ho qala ha kalafo.
Qalong ea phekolo, e baka ho fokotseha ho hoholo ha molumo oa mokelikeli oa extracellular, bongata ba mali a potoloha le bophahamo ba motsotso oa mali, leha ho le joalo, ka mor'a libeke tse 'maloa tsa tšebeliso, matšoao ana a khutlela boemong bo haufi le ba mantlha.
Joalo ka thiazide diuretics, e baka ho fokotseha ha polyuria ho bakuli ba nang le lefu la tsoekere la renal.
Ho qala ketso ke lihora tse 2-4 kamora ho kenella, phello e kholo ke kamora lihora tse 12, nako ea ts'ebetso ke matsatsi a 2-3.

Mofumahali
Ho senya - 50% bakeng sa lihora tse 2.6. Bioavailability ke 64%. Kamora ho tsamaisoa ha molomo ka 50 mg le 100 mg, khatello e kholo e fihlelloa kamora lihora tse 12 mme ke 9.4 le 16.5 mmol / L, ka ho latellana. Puisano le liprotheine tsa plasma - 76%.
Ho felisoa ha halofo ea bophelo ke lihora tse 40-50. E hlahisoa ke liphio li sa fetohe. E kenella ka lebeseng la matsoele. Ha e sa sebetse hantle haholo ka lipelong, e ka ipokella.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka kalafo ea nako e telele, ho khothaletsoa ho fana ka lethal dose e sebetsang e tlase haholo ho boloka phello e nepahetseng, haholo ho bakuli ba tsofetseng.

Ka tekanyo e nyane ea khatello ea mali ea methapo - 25 mg hang ka letsatsi kapa 50 mg makhetlo a 3 ka beke, haeba ho hlokahala, keketseho ea tekanyo ea ho fihlela ho 50 mg / ka letsatsi e ka khonahala.

Ka edematous syndrome, tekanyetso ea pele ke 100-120 mg letsatsi le leng le le leng, maemong a matla, 100-120 mg / letsatsi bakeng sa matsatsi a seng makae a pele (litekanyetso tse kaholimo ho 120 mg hangata ha li hlahise keketseho ea diuretic effect), ka hona ho hlokahala hore o fetele ka tekanyetso ea tlhokomelo ea 100- 50-25 mg / letsatsi makhetlo a 3 ka beke.

Lenate la lefu la tsoekere la sethoathoa (ho batho ba baholo): tekanyetso ea pele ke 100 mg makhetlo a 2 ka letsatsi, tekanyetso ea tlhokomelo ke 50 mg ka letsatsi.

Tekanyo e tloaelehileng ea letsatsi le letsatsi bakeng sa bana ke 2 mg / kg.