Liphetho tsa lefu la tsoekere tsa Chlorhexidine 0,05

Chlorhexidine - sethethefatsi, antiseptic, liforomo tse tlatsitsoeng tsa litekanyetso li sebelisoa ka mokhoa oa bigluconate (Chlorhexidini bigluconas). Chlorhexidine e sebelisitsoe ka katleho e le sebolaya-mafu sa kantle se bolaeang le mafu bakeng sa lilemo tse fetang 60.

Sekhahla sa metsi a 0,55% ka lipompo tsa 100 ml.

Tharollo ea joala ea 0.5% ka lipilara tsa 100 ml.

Chlorhexidine


Khemik'hale ea lik'hemik'hale
IUPAC	N ',N '' '' '-hexane-1,6-diylbisN- (4-chlorophenyl) (imidodicarbonimidic diamide)
Foromo e akaretsang	C₂₂H₃₀Cl₂N₁₀
Boima ba Molar	505.446 g / mol
Cas	55-56-1
PubChem	5353524
Drugbank	APRD00545
Tlhomamiso
ATX	A01AB03 B05CA02, D08AC02, D09AA12, R02AA05, S01AX09, S02AA09, S03AA04
Mefuta ea Litekanyetso
Tsela ea tsamaiso
Litlolo tsa mafura d
Mabitso a mang
"Sebidin", "Amident", "Hexicon", "Chlorhexidine bigluconate"
Wikimedia Commons Media Lifaele

Ho bohlokoa ho hlokomela hore bakeng sa nako eohle ea ts'ebeliso ea khoebo le lipatlisiso tsa saense ea chlorhexidine, ha ho le e 'ngoe ea tsona e ka paka ka mokhoa o kholisang monyetla oa ho thehoa ha likokoana-hloko tse hanyetsanang le chlorhexidine. Leha ho le joalo, ho latela liphuputso tsa morao-rao, tšebeliso ea chlorhexidine e ka baka ho hanyetsa lithibela-mafu ho baktheria (haholoholo, ho hanyetsa ha Klebsiella pneumoniae ho Colistin).

Khemistri, ke dichloro e nang le dichloro e nang le "dichloro" e amanang le "Biguanide". Sebopeho se haufi haholo le bigumal. Moetso oa ts'ebetso ea chlorhexidine ke ho ikopanya le lihlopha tsa phosphate holim'a sele, e hlahise phetoho ho lekana ha osmotic, tlolo ea botshepehi ba sele le lefu la eona.

Chlorhexidine ke sethethefatsi se loantšang likokoana-hloko se sebetsang khahlanong le baktheria e ntle le gram e mpe ea aerobic le anaerobic (Treponema pall>. Setlhare se tsitsitse mme kamora ho ts'ebetsa letlalo (matsoho, tšimo ea ts'ebetso, joalo-joalo) e lula ho eona ka tekanyo e itseng, e tsoelang pele ho fana ka phello ea bactericidal.

Setlhare sena se lula se le teng ha ho na le mali, boladu, leha ho le joalo se fokotsehile. Mefuta e meng ea Pseudomonas spp., Proteus spp. E fokola habonolo ha e na le chlorhexidine, mefuta e thibelang libaktheria e hana. Chlorhexidine e sebetsa maemong a libaktheria feela ka mocheso o phahameng.

Li sebelisetsoa ho phekola lefapha la ho buoa le matsoho a ngaka e buoang, lisebelisoa tsa ho buoa meriana e thibelang likokoana-hloko hammoho le lits'ebetso tsa ho hlapa (ho hlatsoa maqeba a ho buoa, lesapo la senya, jj) le ho thibela mafu a tšoaetsanoang ka thobalano (syphilis, gonorrhea, trichomoniasis). Ntho ea chlorhexidine bigluconate e fumaneha joalo ka tharollo ea metsi ea 20%. Sesebelisoa se lokiselitsoeng ho sebelisa ke tharollo e sa keneleng metsi kapa hydroalicic. Kahoo, bakeng sa ts'ebetso ea ts'imo ea ts'ebetso ea ts'ebetso, tharollo ea 20% e hlapolotsoe ka joala ea ethyl ea 70% ka karolelano ea 1:40. Tharollo e hlahisoang ea 0.5% ea metsi-a joala a chlorhexidine bigluconate e tšoaroa ka makhetlo a 2 le nako ea metsotso e mmedi. Ho sebelisa lisebelisoa tse hlatsoang ka potlako, sebelisa tharollo e tšoanang bakeng sa metsotso e 5. Tharollo ea metsi ea 0.5% e sebelisetsoa ho bolaea likokoana-hloko le ho chesa, tharollo ea joala ea 0.5% kapa tharollo ea metsi ea 1% e sebelisetsoa ho bolaea matsoho. Ha o sebelisa moriana ho phekola matsoho a ngaka e buoang, e ka baka ho omella le ho hlohlona ha letlalo, dermatitis, ho tiea ha letlalo la matsoho nakong ea metsotso e 3-5 ho a khoneha.

supplementory e le 'ngoe e na le 0,016 g ea chlorhexidine bigluconate

Li-suppositories tsa Vaginal (foromo ea masea)

supplementory e le 'ngoe e na le 0,008 g ea chlorhexidine bigluconate.
Gel bakeng sa ts'ebeliso ea lehae le kantle ho 0.5% (100 g ea gel e na le 0.5 g ea chlorhexidine bigluconate).
Tharollo ea tšebeliso ea kantle ea 0.05% (100 ml ea metsi a hloekisitsoeng e na le tharollo ea chlorhexidine bigluconate 20% - 0.25 ml).

Litharollo tsa ho hlaba bokaholimo ba molomo:

0,2% tharollo ea metsi
0.1% tharollo ea chlorhexidine bigluconate ho ethanol (Eludryl).

Chlorhexidine e le moemeli oa prophylactic le kalafo e sebelisoa ka mokhoa o holimo le ka holimo. 0,05%, 0,2% le 0.5% litharollo tsa metsi li sebelisoa ka mokhoa oa ho nosetsa, ho hlaba le ho sebelisa - 5-10 ml ea tharollo e sebelisoa sebakeng se amehang sa letlalo kapa lera la mucous ka ho pepeseha ha metsotso e 1-3. Makhetlo a 2-3 ka letsatsi (ka swab kapa ka ho nosetsa). Ho sebetsanang le lisebelisoa tsa bongaka le likarolo tsa mosebetsi ho etsoa ka seponche se hloekileng se kolobisitsoeng ka tharollo ea antiseptic, kapa ka ho inela. Bakeng sa thibelo ea mafu a tšoaetsanoang ka thobalano, moriana o sebetsa hantle haeba o sa sebelisoe kamora lihora tse peli ka mor'a thobalano. U sebelisa nozzle, kenya lintho tse ka har'a vial ka har'a urethra ea banna (2-3 ml), basali (1-2 ml) le ka hara botshehadi (5-10 ml) metsotso e 2-3. Ho lokisa letlalo la bokaholimo ba lirope, pubis, liphatsa tsa lefutso. Kamora ts'ebetso, u se ke ua ntša metsi ka lihora tse 2. kalafo e rarahaneng ea urethritis le urethroprostatitis e etsoa ka ho kenella ka 2ml ka tharollo ea 0,05% ea chlorhexidine bigluconate makhetlo a 1-2 ka letsatsi ho ea urethra, thupelo ke matsatsi a 10, lits'ebetso li laetsoe letsatsi le leng le le leng. Kahare, keketseho e le 'ngoe ea makhetlo a 3-4 ka letsatsi bakeng sa matsatsi a 7-20, ho latela mofuta oa lefu lena. Rinse le gel bakeng sa tsamaiso ea lihlooho hangata e beoa makhetlo a 2-3 ka letsatsi. Sebaka: tlosa filimi e sirelletsang sebakeng sa setsi ntle le ho ama bandage ka menoana ea hau, ebe u e sebelisa sebakeng se senyehileng sa letlalo. Tobetsa likarolo tsa patch ka menoana ea hau e le hore karolo e thata ea patch e lokise bandage.

Ka 2013, WHO e kenyelelitse tharollo ea 7% ea chlorhexidine bigluconate lenaneng la meriana ea bohlokoa. Ho latela litlhahiso tsa WHO, thapo ea "umbilical cord" e alafshoa ka tharollo ea 7%, e fokotsang monyetla oa ts'oaetso ho masea a sa tsoa hlaha.

kalafo ea tšoaetso ea tšoaetso ea litho tsa botšehali (bacteric vaginosis, trichomoniasis, e sa ikhethang, le ts'oaetso e kopaneng)
maemo a tšohanyetso a thibelo ea mafu a tšoaetsanoang ka thobalano (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis)
tokiso ea "canal" ea bokhachane ho itokisetsa ho beleha le ho tsamaisa nako ea pelehi ho basali ba kotsing ea mathata a tšoaetsanoang le a tšoaetsanoang

Li-supplement tsa "vaginal" li ka sebelisoa ho li-trimesters tsohle tsa boimana le nakong ea kemaro. Li-supplement tsa vaginal li ama membrane ea mucous ka bonolo, ha li ntse li boloka microflora e tloaelehileng ea botšehali. mohloli ha oa hlalosoa matsatsi a 3375

Li-suppositories tsa Vaginal (foromo ea masea)

Gel bakeng sa ts'ebeliso ea lehae le kantle ho 0.5%

kalafo ea maqeba, litlolo, ho chesa, ho chesa
kalafo le thibelo ea tšoaetso ea letlalo le membrane ea mucous
sebelisa ngaka ea meno (gingivitis, stomatitis le periodontitis)
kalafo ea makhopho (e le karolo ea kalafo e rarahaneng)
tlhokomelo ea letlalo kamora lits'ebetso tsa mokhabiso (ho phunya, ho ngola tattoo, ho tebela)
ts'ireletso khahlanong le likokoana-hloko libakeng tsa sechaba, ka tlhaho
Tharollo ea joala ea 0.5% ea chlorhexidine

kalafo ea letsoho ea basebetsi ba bongaka, lingaka tse buoang, kalafo ea letlalo ea masimo a sebetsang le a ente
kalafo ea maqeba a ho buoa ka ho pepesetsoa metsotso e 1-2
ho bolaoa ha lisebelisoa tsa bongaka, lisebelisoa tsa meno, bokaholimo ba lisebelisoa
0,05% tharollo ea metsi a chlorhexidine bigluconate

Ho hlatsoa maqeba, litlolo, ho chesa, ho chesa, ho loma likokoanyana
sebelisa ngaka ea meno (gingivitis, stomatitis, alveolitis, periodontitis)
kalafo ea mafu a ENT (pharyngitis, laryngitis, tonsillitis, otitis media)
ts'ireletso khahlanong le likokoana-hloko libakeng tsa sechaba, ka tlhaho
thibelo ea mafu a likobo
0,2% tharollo e metsi ea chlorhexidine bigluconate

kalafo le ho nchafatsa mokhoa oa setho sa botšehali ho gynecology, urology nakong ea ts'ebetso ea tlhahlobo ea bongaka
ho bolaoa ha meno a tsoang
0.5% tharollo e metsi ea chlorhexidine bigluconate

kalafo ea maqeba le ho chesa, kalafo ea scuffs e nang le tšoaetso le mapetso a letlalo, li-membrane tsa mucous tse bulehileng
sterilization ea sesebelisoa sa bongaka ka mocheso oa 70 ° C
1% tharollo e metsi ea chlorhexidine bigluconate

bakeng sa ho bolaoa ka kakaretso ka likamore, lisebelisoa tsa bohloeki, jj.
kalafo ea lefapha la ho buoa le matsoho a ngaka e buoang pele ho ts'ebetso ea ho buoa, sesepa sa letlalo, kalafo ea ts'ebeliso ea postoperative le maqeba a tukang
Hypersensitivity ho lithethefatsi, dermatitis, allergic reaction. Tšebeliso e le 'ngoe ea litokisetso tsa iodine e sa rateheng e le ho qoba nts'etsopele ea dermatitis. Litharollo tsa Chlorhexidine ha lia lokela ho sebelisoa ho phekola conjunctiva le ho hlatsoa masapo.
Tlhokomeliso Edita
Sebelisa ka hlokolosi bongoaneng.
Chlorhexidine e sebelisoa ho thibela li-STD feela e le mohato oa tšohanyetso (ho phatloha ha likhohlopo, ho kopana ka thobalano le motho ka phoso). Ho kenyelletsa khafetsa khafetsa le chlorhexidine ka har'a urethra ho ka baka ho chesoa ke lik'hemik'hale (haholo-holo ka hypersensitivity ea lithethefatsi), tse ka qetellang li bakile bothata bo tebileng joalo ka thibelo ea urethral. mohloli ha oa hlalosoa matsatsi a 1142 .
Li-supplements tsa Vaginal. Mekhoa ea ho kulisa, ho hlohlona, ho etsahalang kamora ho khaotsa lithethefatsi hoa khoneha. Ho tsoa mali ka matla a fapaneng ho ka etsahala.
Gel. Litla-morao, letlalo le omeletseng, ho hlohlona, ho fifala ha letlalo, dermatitis, ho tiea ha letlalo la matsoho (makhetlo a 3-7) ha u sebelisa li-gel, photosensitivity (ketsahalo ea ho eketsa kutloisiso ea 'mele (hangata letlalo le mucous membrane) ho radiation ea ultraviolet). Ka kalafo ea gingivitis - lits'oants'o tsa enamel ea meno, setlolo sa tartar, ts'oenyeho ea tatso. Enamel le lits'oants'o tsa "enamel" li hlaha haeba ho sebelisoa moriana nako e telele.
Tharollo. Ke ka seoelo e bakang karohano ea ho kulisa, ho hlohlona, ho feta ka mor'a hore moriana o khaoloe.
Ha motho a ka kenella ka tšohanyetso ea lithethefatsi, ha li kenngoe; seretse se tsoang ka mpeng se bontšoa ka lebese, sesepa se bonolo, gelatin kapa lehe le tala.
Ha ho na antidote e tobileng, ka hona, haeba ho na le litla-morao, kalafo ea matšoao e etsoa.

Tšebeliso e kopanetsoeng le iodine ha e khothalletsoe.
Chlorhexidine ha e lumellane le li-detergents tse nang le sehlopha sa anionic (saponins, sodium lauryl sulfate, sulfonic acid, sodium carboxymethyl cellulose) le sesepa. Ho ba teng ha sesepa ho ka ntlafatsa chlorhexidine, ka hona masala a sesepa a lokela ho hlatsuoa hantle pele a sebelisa lithethefatsi.
E theha motsoako o nang le chefo ha o tsoakoa le sodium hypochlorite (NaOCl) - para-chloraniline (n-NH₂C₆H₄Cl). Ho na le bopaki ba hore parachloraniline e chefo (Burkhardt-Holm et al., 1999) lihokela tse sa phethahalang mme e kanna ea baka sebopeho sa methemoglobin.
Ethanol e ntlafatsa katleho ea chlorhexidine.

Li-supplements tsa Vaginal. Ka ntle genitalia ha e ame ho sebetsa hantle le mamello ea litlatsetso tsa botšehali, hobane lithethefatsi li sebelisoa kahare.
Tharollo le gel. Qoba ho kenya lithethefatsi maqeba a bakuli ba nang le khatello ea maikutlo e bulehileng ea craniocerebral, likotsi tsa lesapo la mokokotlo, litlolo tsa membrane ea tympanic. Haeba tharollo e kena liphoofolong tsa leihlo, li lokela ho hlatsuoa kapele le ka metsi. Lintlha tsa polokeho ea li-sheet (MSDS) tsa chlorhexidine bigluconate.
Ho kenella ha lintho tse tšoeu tsa hypochlorite lithong tseo pele li neng li kopana le litokisetso tse nang le chlorhexidine li ka tlatsetsa ponong ea matheba a sootho ho tsona. Matla a bactericidal a eketseha ka mocheso o eketsehileng oa tharollo. Ka lithemparetjha tse kaholimo ho 100 ° C, lithethefatsi lia bola.
Litharollo tse metsi tsa letsoai la chlorhexidine le ka bola (haholoholo ha le futhumetse le alkaline pH) ka ho theoa ha palo ea 4-chloroaniline, e nang le thepa ea carcinogenic.
Taba e hlalositsoe kae? Ntshetsopele ya methemoglobinemia le cyanosis ka masea a tlang pele ho nako ho incubator ka lebaka la chefo ea 4-chloroaniline mohloli ha oa hlalosoa matsatsi a 284 . Incubator e ne e e-na le humidifier ka tharollo ea chlorhexidine, eo ha e futhumetse, e ka bola ho 4-chloroaniline.