Diabeteson MV 60 mg: litaelo tsa tšebeliso

Oral hypoglycemic drug ho tsoa sehlopheng sa sulfonylurea e tsoang molokong oa bobeli.
Litokisetso: DIABETON® MV
Ntho e sebetsang ea lithethefatsi: gliclazide
ATX Encoding: A10BB09
KFG: Setlhare sa molomo sa hypoglycemic
Nomoro ea ngoliso: P. 011940/01
Letsatsi la ho ngolisa: 12.29.06
Mong'a reg. doc.: Mosebeletsi oa Les Laboratoires

Netefatso ea tsoekere ea lefu la tsoekere, liphutheloana tsa lithethefatsi le sebopeho.

Matlapa a lokollotsoeng a tšoeu, a bolile, a ngotsoe ka mahlakoreng ka bobeli: ka ho le leng ke logo ea k'hamphani, ka lehlakoreng le leng - DIA30.

1 tab
gliclazide
30 mg

Lintho tse tsoang ho bona: calcium hydrogen phosphate dihydrate, maltodextrin, hypromellose, magnesium stearate, anhydrous colloidal silicon dioxide.

Li-pcs tse 30 - marang-rang (1) - lipakete tsa karete.
Li-pcs tse 30 - Mabokose (2) - lipakete tsa karete.

Tlhaloso ea lithethefatsi e thehiloe litaelong tse lumelletsoeng ka molao bakeng sa tšebeliso.

Ts'ebetso ea mahlale a tsoekere Diabeteson mv

Setlhare sa "hypoglycemic" se tsoang ho sehlopha sa sulfonylurea se tsoang molokong oa bobeli, se fapaneng le lithethefatsi tse tšoanang ka ho ba le selikalikoe sa "heterocyclic" sa N se nang le endocyclic bond.

Diabeteson MB e fokotsa tsoekere ea mali ka ho tsosa secretion ea insulin ke lisele tsa isanger tsa Langerhans. Kamora kalafo ea lilemo tse peli, bakuli ba bangata ha ba hlahise lithethefatsi (litekanyetso tse eketsehileng tsa insulin ea postprandial le secretion ea C-peptides li sala).

Mofuta oa 2 lefu la tsoekere la mellitus (le sa itšetleheng ka insulin), sethethefatsi se khutlisa tlhoro ea pele ea "insulin secretion" ho arabela tšebeliso ea tsoekere le ho matlafatsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e bonoa ho arabela ts'usumetso ka lebaka la ho ja lijo le tsamaiso ea tsoekere.

Gliclazide e na le phello e phatlalalitsoeng ea extrapancreatic, i.e. e phahamisa kutloisiso ea lisele tsa pherekano ho insulin.

Ho mesifa ea mesifa, phello ea insulin mabapi le tsoekere ea tsoekere, ka lebaka la ntlafatso ea kutloisiso ea methapo ea kutlo e amanang le insulin, e eketseha haholo (+ 35%). Tšusumetso ena ea gliclazide e bakoa haholo ke taba ea hore e khothaletsa ketso ea insulin ho mesifa ea glycogen synthetase mme e baka liphetoho tsa morao-rao ho GLUT4 e amanang le tsoekere.

Diabeteson MB e fokotsa sebopeho sa tsoekere bokong, e nolofalletsa boleng ba "glucose" bo potlakileng.

Ntle le phello ea eona ho metabolism ea carbohydrate, gliclazide e ntlafatsa microcirculation. Lithethefatsi li fokotsa kotsi ea "thrombosis" e nyane ea methapo ea mali, e amang mekhoa e 'meli e ka amehang ho nts'etsopele ea mathata a lefu la tsoekere: ho thibela lintho tse ling ka bongata le ho khomarela le ho fokotseha ha lintho tse ngata tse amanang le mokokotlo oa mokokotlo (beta-thromboglobulin, thromboxane B2) vascular endothelial shughuli le tšebetso e eketsehang ea activator ea plasminogen.

Gliclazide e na le thepa ea antioxidant: e fokotsa sekhahla sa lipid peroxides ho plasma, e eketsa ts'ebetso ea diselutase ea mali a khubelu ea mali.

Pharmacokinetics ea lithethefatsi.

Tlhahiso le kabo

Kamora ho kenya lithethefatsi kahare, gliclazide e kenella ka botlalo ho tsoa ho tšilo ea lijo. Tlhokahalo ea gliclazide ho plasma e eketseha butle-butle, 'me e fihla sehlabeng lihora tse 6 ho isa ho tse ling ka mor'a tsamaiso. Ho ja ha ho ame boemo ba ho monya. Phapang ea motho ka mong e tlaase haholo. Kamano lipakeng tsa lethal dose le plasma ea lithethefatsi ke papatso ea nako.

Tekanyetso e le 'ngoe ea letsatsi le letsatsi ea lefu la tsoekere la MB 30 mg e fana ka motsoako o sebetsang oa plasma ea glycazide nako e fetang lihora tse 24.

Plasma e tlamang ke 95%.

Gliclazide e tšelisoa haholo-holo ka har'a sebete. Li-metabolites tse hlahisoang ha li na mesebetsi ea meriana.

T1 / 2 ke lihora tse 16 (lihora tse 12 ho isa ho tse 20). E hloekisoa haholo ke liphio ka mokhoa oa metabolites, e ka tlase ho 1% - e nang le moroto ka sebopeho se sa fetoheng.

Tekanyetso le tsela ea tsamaiso ea moriana.

Setlhare sena se reretsoe batho ba baholo feela (ho kenyeletsoa bakuli ba lilemo tse 65 le ho feta). Motsoako oa ho qala o khothalelitsoeng ke 30 mg.

Khetho ea moriana e lokela ho etsoa ho latela boemo ba tsoekere maling maling ka mor'a ho qala kalafo. Phetoho e 'ngoe le e' ngoe ea kokoana-hloko e latelang e ka etsoa kamora bonyane libeke tse peli.

Ka kalafo ea tlhokomelo, tekanyetso ea letsatsi le letsatsi e fana ka taolo e sebetsang ea litekanyetso tsa tsoekere ea mali. Tekanyetso ea letsatsi le letsatsi ea lithethefatsi e ka fapana ho tloha ho 30 mg (1 tab.) Ho 90-120 mg (3-4 tab.). Sekhahla se phahameng sa letsatsi ke 120 mg.

Moriana o nooa ka molomo nako e le 1 / letsatsi nakong ea lijo tsa hoseng.

Haeba u fetoa ke tekanyetso e le 'ngoe kapa tse' maloa tsa moriana, u ke ke ua nka tekanyetso e phahameng tekong e latelang.

Bakeng sa bakuli ba sa kang ba fumana kalafo, tekanyetso ea pele ke 30 mg. Ebe mokelikeli o khethoa ka bonngoe ho fihlela phello ea kalafo e lakatsehang e fihlelle.

Diabeteson MV e ka nka sebaka sa Diabeteson ho litekanyetso ho tloha ho matlapa a 1 ho isa ho a 4.

Ho fetoha ho tloha ho sehlahisoa se seng sa hypoglycemic ho ea Diabeton MB ha ho hloke nako ea phetoho. U lokela ho qala ho khaotsa ho sebelisa moriana oa hypoglycemic, 'me feela o lae Diabeteson MB.

Diabeteson MB e ka sebelisoa hammoho le biguanides, alpha-glucosidase inhibitors kapa insulin.

Bakeng sa bakuli ba tsofetseng, litekanyetso li khothalletsoa li tšoana hantle le ho bakuli ba ka tlase ho lilemo tse 65.

Haeba mokuli a kile a fumana kalafo ka litlamorao tsa sulfonylurea tse telele tsa T1 / 2 (ka mohlala, chlorpropamide), ho hlokahala hore ho be leihlo le hlokolosi (taolo ea boemo ba glycemia) bakeng sa libeke tse 1-2 ho qoba nts'etsopele ea hypoglycemia ka lebaka la litlamorao tsa kalafo e fetileng.

Bakeng sa bakuli ba nang le bothata ba ho hlaba hantle ba liphio (CC ho tloha ho 15 ho isa ho 80 ml / min), moriana o laoloa ka tekanyetso e lekanang le ea bakuli ba nang le ts'ebetso e tloaelehileng ea renal.

Side effect Diabeteson mv:

Ho tsoa tsamaisong ea endocrine: hypoglycemia e ka etsahala.

Karolong ea ts'ebetso ea tšilo ea lijo: ho nyekeloa pelo, lets'ollo kapa ho sokela hoa khoneha (hangata ho sa bonoe ha sethethefatsi se laetsoe nakong ea lijo) - hangata - mosebetsi o eketsehileng oa AST, ALT, alkaline phosphatase, maemong a mang - jaundice.

Ho tsoa ho tsamaiso ea hemopoietic: ka seoelo - phokolo ea mali, leukopenia, thrombocytopenia.

Boitšoaro bo kulisang: ha ho hangata - ho hlohlona, ​​urticaria, ramatiki ea maculopapular.

Khokahano ea lithethefatsi:

- lefu la tsoekere la lefu la tsoekere 1 (le itšetlehileng ka insulin),

- lefu la tsoekere ketoacidosis, lefu la tsoekere, lefu la tsoekere,

Ho hlobaela ho matla ha leqhubu kapa ho kula ho hoholo,

- tsamaiso e tšoanang ea miconazole,

- ho anyesa (matsoele),

- bana le bacha ba ka tlase ho lilemo tse 18,

- Hypersensitivity ho gliclazide kapa mang kapa mang ea fumanang lithethefatsi, tse ling tse fumanoeng sulfonylurea, sulfonylamides.

Ha ho khothalletsoe ho sebelisa lithethefatsi hammoho le phenylbutazone kapa danazole.

Sebelisa nakong ea bokhachane le pelehi.

Ha ho na datha ea tlhahlobo ea bongaka e sa lekaneng ea ho lekola kotsi ea ho se sebetse hantle le litlamorao tsa fetoto ka lebaka la ts'ebeliso ea gliclazide nakong ea kemolo. Ka hona, ts'ebeliso ea Diabeteson MV sehlopheng sena sa bakuli e hanyetsitsoe.

Ha ho ima ho etsahetse ha u ntse u sebelisa moriana, ha ho na lebaka le hlakileng la ho felisoa ha lona. Maemong a joalo, hammoho le moimana o reriloeng, moriana o lokela ho khaotsa mme kalafo e lokela ho tsoelapele feela ka litokisetso tsa insulin tlasa tlhokomelo e haufi le matšoao ohle a laboratori ea metabolism ea carbohydrate. Tlhahlobo ea Neonatal ea tsoekere ea mali le eona e khothalletsoa.

Ha ho tsejoe hore na gliclazide e pepesitsoe lebeseng la matsoele, ha ho na bopaki ba kotsi ea ho ba le neonatal hypoglycemia. Ntlheng ena, kalafo e nang le gliclazide nakong ea ho anyesa e hapuoe.

Boithutong ba liphoofolo ba liteko, ho bontšitsoe hore litlamorao tsa sulfonylurea ka tekanyetso e phahameng li na le phello ea teratogenic.

Litaelo tse khethehileng bakeng sa ho sebelisa Diabeteson mv.

Ha ho fana ka tlhahiso ea lefu la tsoekere la Diabeteson, ho lokela ho hopoloa hore hypoglycemia e ka hlaha ka lebaka la ho nkela lintho tse tsoang ho sulfonylurea, 'me maemong a mang e le ka mokhoa o thata le o tšoarellang, o hlokang hore ho be le sepetlele le tsamaiso ea tsoekere ka matsatsi a' maloa.

Bakeng sa ho qoba nts'etsopele ea hypoglycemia, ho khethoa bakuli ka hloko le khetho ea motho ka mong, hammoho le ho fa mokuli tlhaiso-leseling e felletseng ka kalafo e boletsoeng.

Ha u sebelisa lithethefatsi tsa hypoglycemic ho bakuli ba tsofetseng, batho ba lulang ba sa fumane phepo e lekaneng, ba nang le boemo bo fokolang ba kakaretso, ho bakuli ba nang le bothata ba ho hlonepha kapa ho hlonephaha ha tlhaho, kotsi ea ho ba le hypoglycemia e eketseha.

Matšoao a hypoglycemia ho thata ho a tseba ho batho ba baholo le ho bakuli ba fumanang kalafo ea beta-blocker.

Ha ho fana ka lefu la tsoekere la Diabetes ho Bokuli ba tsofetseng, ho hlokahala hore ho hlahlojoe maemo a tsoekere ea mali ka hloko. Phekolo e lokela ho qala butle butle 'me matsatsing a pele a kalafo ho hlokahala ho laola tsoekere e potlakileng le ka mor'a ho ja.

Diabeteson MB e ka fuoa feela bakuli ba fumanang lijo khafetsa, tseo hangata li kenyelletsang lijo tsa hoseng 'me li fana ka phepo e lekaneng ea lik'habohaedreite. Hypoglycemia hangata e hlaha ka ho ja lijo tse nang le khalori e tlase, ka mor'a ho ikoetlisa nako e telele kapa ho ikoetlisa ka mor'a ho noa joala kapa ka ho sebelisa lithethefatsi tse 'maloa tsa hypoglycemic ka nako e le' ngoe.

Ha matšoao a jaundice ea cholestatic a hlaha, kalafo e lokela ho kenella. Kamora ho khaotsa ho lefu la tsoekere la MB, matšoao ana hangata a nyamela.

Bakeng sa bakuli ba nang le bothata bo matla ba hepatic le / kapa renal, ho na le phetoho mokhoeng oa pharmacokinetic le / kapa oa pharmacodynamic oa gliclazide. Haholo-holo, ho haelloa ke hepatic kapa renal haholo ho ka ama ho hasoa ha gliclazide 'meleng. Ho haella ha hepatatic ho ka thusa ho fokotsa glucogeneis. Litholoana tsena li eketsa kotsi ea ho ba le maemo a hypoglycemic. Hypoglycemia e hlahang ho bakuli bana e ka ba telele haholo, maemong a joalo, ho hlokahala kalafo e loketseng hanghang.

Taolo ea litekanyetso tsa tsoekere ea mali ho bakuli ba fumanang li-hypoglycemic agents e ka fokotsoa maemong a latelang: feberu, ho lemala, mafu a tšoaetsanoang kapa ho kenella ha ho buuoa. Maemong a joalo, ho kanna ha hlokahala hore o khaotse ho phekoloa le Diabeteson MV le ho fana ka kalafo ea insulin.

Katleho ea Diabeteson MB (hammoho le lithethefatsi tse ling tsa molomo tsa "hypoglycemic") ho bakuli ba bang e kanna ea fokotseha kamora nako e telele. Sena se ka bakoa ke ho eketseha ha lefu la tsoekere kapa ho fokotseha ha karabelo ea moriana. Ketsahalo ena e tsejoa e le ho hanyetsa lithethefatsi tsa bobeli, tse lokelang ho khetholloa ho tloha ho mantlha ha moriana o laetsoe khetlo la pele mme o sa hlahise phello e lebelletsoeng. Pele o tseba mokuli ka ho haella ha kalafo ea lithethefatsi, ho hlokahala hore ho hlahlojoe ho lekana ha khetho ea lethal dose le tumellano ea mokuli le lijo tse boletsoeng.

Ka morao ho kalafo le Diabeteson MB, phenylbutazone le danazole ha li khothaletsoe. Ho molemo ho sebelisa NSAID e 'ngoe.

Khahlano le semelo sa kalafo le lefu la tsoekere la MB, ho bohlokoa ho lahla tšebeliso ea lino tse tahang kapa litlhare tse kenyeletsang ethanol.

Hoa hlokahala ho tsebisa mokuli le litho tsa lelapa la hae ka kotsi ea ho ba le hypoglycemia, matšoao a eona le maemo a tsamaisanang le kholo ea eona. Hoa hlokahala hape ho hlalosa hore na khanyetso ea lithethefatsi ea mantlha le ea bobeli ke efe. Mokuli o tlameha ho tsebisoa ka kotsi e ka bang teng le melemo ea kalafo e boletsoeng, hape hoa hlokahala ho mo joetsa ka mefuta e meng ea kalafo. Mokuli o hloka ho hlakisa bohlokoa ba phepo e sa fetoheng, tlhoko ea ho ikoetlisa khafetsa le ho shebella matšoao a tsoekere ea mali le moroto.

Tlhokomelo ea laboratori

Hoa hlokahala ho tseba khafetsa maemo a glucose le hemoglobin ea glycosylated maling, sethaleng sa glucose ka har'a moroto.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Bakuli ba lokela ho hlokomela matšoao a hypoglycemia mme ba sebelise tlhokomeliso ha ba khanna kapa ba etsa mosebetsi o hlokang sekhahla se phahameng sa maikutlo a psychomotor.

Bongata ba lithethefatsi:

Matšoao: hypoglycemia, maemong a tebileng - e tsamaeang le komisi, ho akheha le mathata a mang a methapo ea methapo.

Phekolo: Matšoao a itekanetseng a hypoglycemia a lokisoa ka ho nka lik'habohaedreite, ho khetha tekanyetso le / kapa ho fetola lijo. Ho lekola ka hloko boemo ba mokuli ho lokela ho tsoelapele ho fihlela ngaka e eang e netefatsa hore bophelo ba mokuli ha bo kotsing. Maemong a boima, tlhokomelo ea bongaka ea tšohanyetso le ho kena sepetlele hang-hang lia hlokahala.

Haeba hypoglycemic coma e belaelloa kapa e fumanoa, mokuli o kenngoa ka potlako ka 50 ml ea tharollo e kopantsoeng ea dextrose (glucose) 40% iv. Ebe tharollo ea "dextrose" (glucose) e hlapolotsoeng ka ho fetesisa ea 5% e tsamaisoa ka har'a methapo bakeng sa ho boloka sekhahla se hlokahalang sa tsoekere maling. Ho lekola ka hloko ho lokela ho etsoa bonyane nakong ea lihora tse 48 tse tlang. Nakong e tlang, ho latela boemo ba mokuli, potso ea tlhokeho ea ho lekola mesebetsi ea bohlokoa ea mokuli e lokela ho etsoa qeto.

Ho bakuli ba nang le mafu a sebete, tumello ea plasma ea gliclazide e kanna ea lieha. Ho buoa ka bongata hangata ha ho etsetsoe bakuli ba joalo ka lebaka la tlama ea "gliclazide" ea liprotheine tsa plasma.

Tšebelisano ea Diabeteson MV le lithethefatsi tse ling.

Lithethefatsi tse eketsang litlamorao tsa Diabeteson MB

Tšebeliso e tšoanang ea Diabeteson MB e nang le miconazole (bakeng sa ts'ebeliso ea ts'ebetso) e ntlafatsa nts'etsopele ea hypoglycemia ho fihlela ho akheha.

Motsoako ha oa khothalletsoa

Phenylbutazone (bakeng sa ts'ebeliso ea ts'ebetso) e ntlafatsa phello ea hypoglycemic ea litokollo tsa sulfonylurea, joalo ka e fetola litlamo tsa bona ka liprotheine tsa plasma mme / kapa e liehisa ho tsoa ha tsona 'meleng.

Ka tšebeliso e tšoanang ea Diabeteson MB, lithethefatsi tse nang le ethanol le ethanol li eketsa hypoglycemia, li sitisa maikutlo a lumellanang mme li ka kenya letsoho kholisong ea komello ea hypoglycemic.

Litlhokomelo tse khethehileng

Ts'ebeliso e ts'oanang ea beta-blockers e pata matšoao a hypoglycemia, a kang palpitations le tachycardia. Boholo ba lithibelo tse ngata tse sa ikhetheng li eketsa sekhahla le ho teba ha hypoglycemia.

Fluconazole e eketsa nako ea T1 / 2 sulfonylureas hape e eketsa kotsi ea hypoglycemia.

Ts'ebeliso e tšoanang ea ACE inhibitors (Captopril, enalapril) e ka mpefatsa phello ea hypoglycemic ea litokollo tsa sulfonylurea (ho latela khopolo-taba e le 'ngoe, mamello ea glucose e ntlafatsoa ka ho fokotseha ho latelang ha litlhoko tsa insulin). Boitšoaro ba Hypoglycemic ha bo na seoelo.

Lithethefatsi tse fokotsang phello ea Diabeteson MV

Motsoako ha oa khothalletsoa

Ka tšebeliso e le 'ngoe le danazol, ho fokotseha ha ts'ebetso ea Diabeteson MB hoa khoneha.

Litlhokomelo tse khethehileng

Ts'ebeliso e kopaneng ea Diabeteson MB le chlorpromazine ka tekanyetso e phahameng (ho feta 100 mg / ka letsatsi) e ka lebisa ho eketseha ha litekanyetso tsa tsoekere ea mali ka lebaka la ho fokotseha ha secretion ea insulin.

Ka tšebeliso e tšoanang ea GCS (bakeng sa ts'ebeliso ea kemiso, ea kantle le ea lehae) le li-tetracosactides, litekanyo tsa tsoekere ea mali li eketseha ka nts'etsopele ea ketoacidosis (ho fokotseha ha mamello ea glucose tlasa ts'usumetso ea GCS).

Ka tšebeliso e tšoanang ea Diabeteson MB le li-progestogens, phello ea lefu la tsoekere ea li-progestogen tse lekantsoeng e phahameng e lokela ho tsotelloa.

Ha e sebelisoa hammoho, li-stimulants tsa 2-adrenoreceptor (bakeng sa ts'ebeliso ea kemiso) - ritodrin, salbutamol, terbutaline e eketsa tsoekere ea mali (ho itlhahloba ha maemo a tsoekere ea mali e lokela ho fanoa, haeba ho hlokahala, ho fetisetsa mokuli ho insulin ho ka hlokahala).

Haeba ho hlokahala, ts'ebeliso ea metsoako e kaholimo e lokela ho fana ka taolo ea maemo a tsoekere ea mali. Ho ka ba le tlhoko ea tokiso ea litekanyetso tse eketsehileng tsa Diabeteson MB ka bobeli nakong ea phekolo e kopanetsoeng le kamora ho tlosoa ha moriana o mong o eketsehileng.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - litafole tsa tokollo tse fetotsoeng.

Sebopeho ka ho penta e le 'ngoe:

• Ntho e sebetsang: Gliclazide - 60.0 mg.
• Baeti: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cP. 160.0 mg, magnesium stearate 1.6 mg, silicon dioxide colloidal anhydrous 5.04 mg.

Pharadodynamics

Gliclazide ke sulfonylurea derivative, setlhare sa molomo sa hypoglycemic se fapaneng le lithethefatsi tse tšoanang ka ho ba teng ka reng ea Nter e nang le heterocyclic e nang le endocyclic bond.

Glyclazide e theola tsoekere ea mali ka ho tsosa secretion ea insulin ke lisele tsa beta tsa lihlekehleke tsa Langerhans. Keketseho ea boemo ba insulin ea postprandial le C-peptide e phehella kamora lilemo tse peli tsa kalafo.

Ntle le phello ea metabolism ea carbohydrate, gliclazide e na le litlamorao tsa hemovascular.

Litla-morao tsa pelo

Glyclazide e fokotsa kotsi ea ts'ebetso ea methapo e fokolang ea mali ts'ebetso e eketsehileng ea activator ea tisy ea plasminogen.

Suction

Kamora ho tsamaisoa ka molomo, gliclazide e kenella ka botlalo. Keketseho ea "gliclazide" plasma ea mali e eketseha butle butle nakong ea lihora tse 6 tsa pele, boemo ba sethala bo lula ho tloha lihora tse 6 ho isa ho tse 12.

Phapang ea motho ka mong e tlaase. Ho ja ha ho ame sekhahla kapa boholo ba ho monya gliclazide.

Metabolism

Gliclazide e tšelisoa haholo-holo ka har'a sebete. Ha ho na metabolites e sebetsang ho plasma.

Glyclazide e hloekisoa haholo ke liphio: li-excretion li etsoa ka mokhoa oa metabolites, e ka tlase ho 1% e hlahisoang ke liphio li sa fetoloe. Halofo ea bophelo ba gliclazide e ka kakaretso ho tloha lihora tse 12 ho isa ho tse 20.

Matšoao a ho sebelisoa

Lithethefatsi Diabeteson MV 60 mg e fuoe bakuli ba lilemo tse fetang 18 bakeng sa kalafo ea maemo a latelang:

• Type 2 lefu la tsoekere la mellitus le sa sebetsang hantle kalafo ea ho ja, ho ikoetlisa le ho theola boima ba 'mele.
• Thibelo ea mathata a lefu la tsoekere: ho fokotsa kotsi ea mathata a amanang le lefu la sethoathoa (lefu la pelo le lefu la sethoathoa, stroke) ho bakuli ba nang le mofuta oa 2 lefu la tsoekere ka taolo e matla ea glycemic.

Tekanyetso le tsamaiso

Setlhare sena se laeloa feela batho ba baholo!

Tekanyo e khothalelitsoeng e lokela ho nooa ka molomo, nako e le 'ngoe ka nako ea lijo tsa hoseng. Tekanyetso ea letsatsi le letsatsi e kanna ea ba 30 -120 mg (matlapa a 1/2) ka tekanyetso e le 'ngoe. Ho khothalletsoa ho metsa letlapa kapa halofo ea letlapa lohle ntle le ho hlafuna kapa ho silafatsa.

Haeba u fetoa ke tekanyetso e le 'ngoe kapa tse' maloa tsa moriana, u ke ke ua nka tekanyetso e phahameng ho lethal e latelang, tekanyetso e lahlehileng e lokela ho nooa ka le hlahlamang.

Joalo ka lithethefatsi tse ling tsa hypoglycemic, lethal dose la lithethefatsi boemong ka bong le tlameha ho khethoa ho latela bongata ba tsoekere ea mali le HbAlc.

Tekanyetso ea pele

Tekanyetso ea pele e khothalelitsoeng (ho kenyelletsa le ho bakuli ba tsofetseng 30 mg ka letsatsi (Letlapa le le 1/2).

Tabeng ea taolo e lekaneng, sethethefatsi tekanyetso ena se ka sebelisoa bakeng sa kalafo ea tlhokomelo. Ka taolo e sa lekaneng ea glycemic, tekanyetso ea letsatsi le letsatsi ea lithethefatsi e ka eketseha ka tatellano ho isa ho 60, 90 kapa 120 mg.

Keketseho ea lethal dose e khonahala eseng pele ho khoeli ea 1 ea kalafo ea lithethefatsi ka tekanyetso e boletsoeng esale pele. Mokhelo ke bakuli bao khatello ea bona ea tsoekere ea mali e sa fokotsehang kamora libeke tse peli tsa kalafo. Maemong a joalo, tekanyetso e ka eketseha libeke tse 2 kamora ho qala tsamaiso.

Tekanyo e phahameng ka ho fetisisa e khothalletsoang ea letsatsi le letsatsi ea lithethefatsi ke 120 mg.

Letlapa le le leng la lithethefatsi la Diabeteson® MV ea lithethefatsi le tokollo e fetotsoeng ea 60 mg e lekana le matlapa a mabeli a matlapa a Diabeteson® MV ka tokollo e fetotsoeng ea 30 mg Ho ba teng ha notch litafoleng tsa 60 mg ho u fa monyetla oa ho arola letlapa le ho nka tekanyetso ea letsatsi le letsatsi ea 30 mg (1/2 piritsi ea 60 mg), mme, ha ho hlokahala, 90 mg (1 le 1/2% 60 mg).

Ho fetoha ho tsoa ho moemeli e mong oa hypoglycemic ho Diabeteson MV 60 mg

Diabeteson®: Matlapa a MV a nang le tlhahiso e fetotsoeng ea 60 mg a ka sebelisoa sebakeng sa lithethefatsi tse ling tsa hypoglycemic bakeng sa tsamaiso ea molomo. Ha u fetisetsa bakuli ba fumanang lithethefatsi tse ling tsa hypoglycemic bakeng sa tsamaiso ea molomo ho Diabeteson® MV, tekanyo ea bona le halofo ea bophelo e lokela ho ananeloa. Ha e le molao, nako ea phetoho ha e hlokehe. Tekanyetso ea pele e lokela ho ba 30 mg mme ebe ea kenngoa ka bongata ho latela bongata ba tsoekere ea mali. Ha Diabeteson® MV e nkeloa sebaka ka tse tsoang haling ea sulfonylurea ka nako e telele ea halofo ea bophelo ho qoba hypoglycemia e bakoang ke tšusumetso ea likhahla tse peli tsa hypoglycemic, o ka emisa ho li nka matsatsi a 'maloa.

Tekanyetso ea pele ea lithethefatsi Diabeteson® MV le eona e na le 30 mg (1/2 piritsi ea 60 mg) mme, haeba ho hlokahala, e ka eketsoa ho ea pele, joalo ka ha ho hlalositsoe kaholimo.

Bakuli ba Kotsi ea Hypoglycemia

Ho bakuli ba kotsing ea ho ba le hypoglycemia (phepo e sa lekaneng kapa e sa leka-lekanang, mathata a endocrine a tebileng kapa a sa fuoang hantle: ho hloka tlhokomelo ea pituitary adrenal, hypothyroidism, ho tlosoa hoa glucocorticosteroids (GCS) kamora ts'ebeliso e telele le / kapa tsamaiso litekanyetso tse phahameng, mafu a matla a pelo. Sistimi - lefu le matla la coronary, lefu le matla la methapo ea methapo ea pelo, ho khothalletsoa ho sebelisa tekanyetso e tlase (30 mg) ea moriana. Diabeteson® MV.

Thibelo ea mathata a lefu la tsoekere

Ho fihlella taolo e matla ea glycemic, butle-butle o ka eketsa lethalinyana la Diabeteson® MV ho isa ho 120 mg / ka letsatsi, ho kenyelletsa lijo le boikoetliso, ho fihlela boemo ba HbAlc ba sepheo. Hopola kotsi ea ho ba le hypoglycemia. Ntle le moo, lithethefatsi tse ling tsa hypoglycemic, mohlala, metformin, alpha-glucosidase inhibitor, hyazolidinedione derivative kapa insulin, li ka eketsoa ho tsa bongaka.

Ts'ebeliso ea moriana nakong ea kemaro le lactation

Ha ho na tlhahisoleseling mabapi le monyetla oa ho sebelisa matlapa a Diabeteson MV nakong ea kemaro ke mosali. Leha taba ea hore liphuputso tsa liphoofolo li sa netefatsa litla-morao tsa lehe le pōpelong, sethethefatsi sena se kopantsoe bakeng sa kalafo ea basali baimana. Haeba lefu la tsoekere le fumanoa ho basali nakong ea kemero, mokuli o khethoa kalafo e 'ngoe e ke keng ea ba kotsi ho fetus. Boemong bona, ngaka e lula e lekola boemo bo akaretsang ba mosali.

Haeba mosali a ne a phekoloa ka lefu la tsoekere la MV, mme bokhachane bo se bo qalile, kalafo e lokela ho emisoa hanghang mme o bone ngaka, etsa bonnete ba ho tsebisa ka ho nka moriana.

Tšebeliso ea sethethefatsi sena sa hypoglycemic nakong ea matsoele e thibetsoe, hobane likarolo tse sebetsang tsa lithethefatsi li ka kenella ka lebese, ebe li kena 'meleng oa ngoana. Haeba ho hlokahala, kalafo ea lithethefatsi e lokela ho khaotsa.

Hypoglycemia

Joalo ka lithethefatsi tse ling tsa sehlopha sa sulfonylurea, lithethefatsi Diabeteson MV li ka baka hypoglycemia haeba ho ka ba bonolo hore motho a je haholo, haholoholo ha ho sa jeoa lijo. Matšoao a ka bang teng a hypoglycemia: ho opeloa ke hlooho, tlala e matla, ho nyekeloa, ho felloa ke matla, ho tšoenyeha ha boroko, ho teneha, ho fokotseha ha tlhokomelo, ho lieha ho arabela, khatello ea maikutlo, pherekano, pono e sa hlakang le puo, aphasia, ho thothomela, paresis, tahlehelo ea boitšoaro , maikutlo a ho hloka thuso, pono e sa tsitsang, ho tsekela, ho fokola, ho tsitsipana, bradycardia, delirium, ho hema ka thata, ho otsela, ho felloa ke letsoalo ka ho khona ho holofala ho fihlela lefung.

Boitšoaro ba Andrenergic bo ka hlokomeleha: ho eketseha ha mofutsoana, letlalo le "khang", ho tšoenyeha, tachycardia, khatello e phahameng ea mali, ho phahamisa mahlo, arrhythmia, le angina pectoris.

Ha e le molao, matšoao a hypoglycemia a emisoa ka ho nka limatlafatsi (tsoekere).

Ho nka li-sweeteners ha ho na thuso. Khahlano le semelo sa tse ling tse tlisoang ke sulfonylurea, liphapang tsa hypoglycemia li ile tsa lemohuoa kamora phomolo e atlehileng.

Ho hypoglycemia e matla kapa ea nako e telele, ho bontšoa tlhokomelo ea bongaka ea tšohanyetso, mohlomong ka ho kena sepetlele, le haeba ho e-na le phello ea ho nka lik'habohaedreite.

Litla-morao tse ling

• Ho tsoa pampiring ea ka mpeng: bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho sokela. Ho nwa moriana nakong ea lijo tsa hoseng ho qoba matšoao ana kapa ho a fokotsa.
• Karolong ea letlalo le lisele tse poteletseng: rash. ho hlohlona urticaria, edema ea Quincke, erythema, ramatiki ea maculopapullous, maikutlo a lipolao (joalo ka Stevens-Jones syndrome le chefo e matla ea chefo ea morao-rao).
• Litho tsa Hematopoietic le tsamaiso ea methapo: mafu a hematological (anemia, leukopenia, thrombocytopenia, granulocytopenia) ha a na seoelo.
• Karolong ea sebete le tsamaiso ea biliary: tšebetso e eketsehang ea li-enzymes tsa "sebete" (aspartate aminotransferase (ACT), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (linyeoe tse ikhethileng). Haeba choleundatic jaundice e etsahala, phekolo e lokela ho khaotsa.
• Ho tloha lehlakoreng la setho sa pono: Litšitiso tsa nakoana tsa pono li ka hlaha ka lebaka la phetoho ea khatello ea tsoekere ea mali, haholoholo qalong ea kalafo.

Ho sebelisana le lithethefatsi tse ling

Lithethefatsi Diabeteson MV 60 mg ha ea lokela ho nkuoa ka mokhoa o ts'oanang le miconazole, kaha ts'ebelisano ena e baka keketseho ea phello ea hypoglycemic, e ka lebisang ho ntlafatsoang ha hypoglycemic coma.

Setlhare sena se ka fokotsa phello ea kalafo ea lithibela-pelehi tsa molomo, ka hona, bakuli ba sebelisang mokhoa ona oa ts'ireletso ba lokela ho lemosoa ka kotsi ea ho ima e sa batleheng.

Setlhare sena ha se khothalletsoe ho kopantsoe le lithethefatsi tse kenyelletsang ethanol, kaha sena se ka lebisa ho eketseha ha phello ea hypoglycemic le nts'etsopele ea mathata a matla a sebete.

Lipehelo tsa Khefu ea Litlama

Lithethefatsi tse latelang ke liano tsa lithethefatsi Diabeteson MV:

• Matlapa a Glidiab
• Glidiab MV,
• Diabefarm MV,
• Gliclazide MV.

Pele o nka moriana o khethiloeng ka analog, mokuli o lokela ho lula a buisana le setsebi sa endocrinologist.

Litsenyehelo tse tloaelehileng tsa lithethefatsi Diabeteson MV 60 mg ho litlhare tsa Moscow ke li-ruble tse 150-180 ka pakete (matlapa a 30).

Foromo ea boholo:

Moetso:
Letlapa le leng le na le:
Lintho tse sebetsang: gliclazide - 60.0 mg.
Baeti: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cp 160.0 mg, magnesium stearate 1.6 mg, anhydrous colloidal silicon dioxide 5.04 mg.

Tlhaloso
White, biconvex, matlapa a oval a nang le notch le ho ngola "DIA" "60" ka mahlakoreng ka bobeli.

Sehlopha sa Pharmacotherapeutic:

Khoutu ea ATX: A10BB09

TLHALOSO YA PHARMACOLOGICAL

Pharadodynamics
Glyclazide ke sulfonylurea derivative, setlhare sa molomo sa hypoglycemic se fapaneng le lithethefatsi tse tšoanang ka ho ba teng ka reng ea Nter e nang le heterocyclic e nang le endocyclic bond.
Gliclazide e fokotsa bongata ba tsoekere ea mali, e tsosetsang sephiri sa insulin ka li-β-cell tsa lihlekehleke tsa Langerhans. Keketseho ea khatello ea mali ea postprandial insulin le C-peptide e phehella kamora lilemo tse peli tsa kalafo.
Ntle le phello ea metabolism ea carbohydrate, gliclazide e na le litlamorao tsa hemovascular.

Kameho ho secretion ea insulin
Ho mofuta oa 2 lefu la tsoekere, lithethefatsi li khutlisa tlhoko ea pele ea "insulin secretion" ho arabela tšebeliso ea tsoekere le ho matlafatsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e bonoa ho arabela ho ts'oaroa ka lebaka la takatso ea lijo kapa tsamaiso ea tsoekere.

Litla-morao tsa pelo
Glyclazide e fokotsa kotsi ea "thrombosis" e nyane ea methapo ea mali ka ts'usumetso e ka lebisang tlhabisong ea mathata a lefu la tsoekere: ho thibela likarolo tse ling tsa sethala le ho khomarela le ho fokotseha ha lintho tse ngata tse amanang le ho sebetsa ka liplatelete (beta-thromboglobulin, thromboxane B)₂), hammoho le ho khutlisetsa tšebetso ea fibrinolytic ea vasotine endothelium le ho eketsa tšebetso ea activator ea plasminogen.
Taolo e matla ea glycemic e thehiloeng ts'ebelisong ea Diabeteson ® MV (HbA1c Leano la taolo e matla ea glycemic le kenyellelitse ho beoa ha lithethefatsi Diabeteson ® MV le ho eketsa tekanyetso ea eona khahlanong le semelo sa (kapa ho e-na le kalafo e tloaelehileng pele ho e eketsa lithethefatsi tse ling tsa hypoglycemic (mohlala, metformin, alpha-glucosidase inhibitor , derivative of thiazolidinedione or insulin. Karolelano ea litekanyetso tsa letsatsi le letsatsi tsa lithethefatsi Diabeteson ® MV ho bakuli ba sehlopha se matla sa taolo e ne e le 103 mg, palo e phahameng ka ho fetisisa letsatsi le letsatsi lethal dose e ne e le 120 mg.
Khahlano le nalane ea ts'ebeliso ea lithethefatsi Diabeteson ® MV sehlopheng se matla sa taolo ea glycemic (nako ea ho latela lilemo tse 4,8, tekanyo ea HbA1c ea 6.5%) ha e bapisoa le sehlopha se laoloang (kakaretso ea HbA1c level 7.3%), ho bontšoa ho fokotseha ho hoholo ha 10% kotsi e lekanang ea maqhubu a kopaneng a mathata a maholo ka ho fetisisa le a manyane
Monyetla ona o fumanoe ka ho fokotsa kotsi e kaalo: mathata a maholo a microvascular ka 14%, ho qala le ho tsoelapele ha nephropathy ka 21%, ho hlaha ha microalbuminuria ka 9%, macroalbuminuria ka 30% le nts'etsopele ea mathata a renal ka 11%.
Melemo ea taolo ea glycemic e matla ha u ntse u nka Diabeteson ® MV ha ea ka ea itšetleha ka melemo e fumanoeng ka kalafo ea antihypertensive.

Mofumahali

Suction
Kamora ho tsamaisoa ka molomo, gliclazide e kenella ka botlalo. Keketseho ea "gliclazide" plasma ea mali e eketseha butle butle nakong ea lihora tse 6 tsa pele, boemo ba sethala bo lula ho tloha lihora tse 6 ho isa ho tse 12. Phapang ea motho ka mong e tlaase.
Ho ja ha ho ame sekhahla kapa boholo ba ho monya gliclazide.

Tsamaiso
Hoo e ka bang 95% ea glycazide e tlama ho protheine ea plasma. Bophahamo ba kabo ea thepa e ka ba lilithara tse 30.Ho nka moriana oa lefu la tsoekere la Diabeteson ® MV ka lethal dose ea 60 mg hang ka letsatsi ho tiisa hore ho na le ts'ebetso ea "gliclazide" e sebetsang hantle ka har'a plasma ea mali ka nako e fetang lihora tse 24.

Metabolism
Gliclazide e tšelisoa haholo-holo ka har'a sebete. Ha ho na metabolites e sebetsang ho plasma.

Ho tsala
Glyclazide e hloekisoa haholo ke liphio: li-excretion li etsoa ka mokhoa oa metabolites, e ka tlase ho 1% e hlahisoang ke liphio li sa fetoloe. Bophelo ba halofo ea gliclazide ke karolelano ea lihora tse 12 ho isa ho tse 20.

Linearity
Kamano lipakeng tsa lethal dose e nkuoeng (ho fihlela ho 120 mg) le sebaka se ka tlasa "khatello ea nako" ea pharmacokinetic curve "- time".

Baahi ba ikhethang
Batho ba baholo
Ho batho ba tsofetseng, ha ho na liphetoho tse kholo maemong a pharmacokinetic.

LIPUO TSA SEBELISO

• Type 2 lefu la tsoekere la mellitus le sa sebetsang hantle kalafo ea ho ja, ho ikoetlisa le ho theola boima ba 'mele.
• Thibelo ea mathata a lefu la tsoekere: ho fokotsa kotsi ea mathata a amanang le lefu la sethoathoa (lefu la pelo le lefu la sethoathoa, stroke) ho bakuli ba nang le mofuta oa 2 lefu la tsoekere ka taolo e matla ea glycemic.

• hypersensitivity ho gliclazide, tse ling tse tsoang ho sulfonylurea, sulfonamides kapa ho li-excipients tseo e leng karolo ea lithethefatsi,
• mofuta oa 1 lefu la tsoekere
• lefu la tsoekere ketoacidosis, lefu la tsoekere, lefu la tsoekere,
• a renal e matla kapa a haelloa ke hepatic (maemong ana, ho khothalletsoa ho sebelisa insulin),
• ho nka miconazole (bona karolo "Ho sebelisana le lithethefatsi tse ling"),
• nako ea kemaro le kemaro ea pelehi (bona karolo "Nako ea kemaro le nako ea pelehi"),
• lilemo tse 18.

Ka lebaka la hore litokisetso li na le lactose, Diabeteson MV ha e khothalletsoe ho bakuli ba nang le ts'oarelo ea lactose ts'oarello, galactosemia, glucose-galactose malabsorption.
Ha e khothalletsoe hore e sebelisoe hammoho le phenylbutazone kapa danazole (bona karolo "Tšebelisano le lithethefatsi tse ling").

Ka tlhokomelo
Ho tsofala, ho se lekane le / kapa phepo e sa leka-lekanang, khaello ea glucose-6-phosphate dehydrogenase, mafu a matla a tsamaiso ea methapo ea pelo, hypothyroidism, adrenal kapa pituitary insuffence, renal le / kapa ho hloleha ha sebete, kalafo ea nako e telele le glucocorticosteroids (GCS), botahoa.

MOTSOALLE OA HO FIHLA LE HO FINYELETSA PELE

Boimana
Ha ho na boiphihlelo ka gliclazide nakong ea kemolo. Lintlha tse mabapi le tšebeliso ea tse ling tse tsoang sulfonylurea nakong ea kemaro li na le moeli.
Boithutong ba liphoofolo tse sebelisoang ka laboratoring, litla-morao tsa "gliclazide" ha li so tsejoe.
Ho fokotsa kotsi ea tšoaetso ea tlhaho ea tlhaho, ho hlokahala hore ho laoloe hantle (kalafo e nepahetseng) ea lefu la tsoekere. Lithethefatsi tsa molomo tsa molomo nakong ea kemolo ha li sebelisoe.
Insulin ke lithethefatsi tsa khetho bakeng sa kalafo ea lefu la tsoekere ho basali baimana.
Ho khothalletsoa ho nka sebaka sa ts'ebeliso ea lithethefatsi tsa molomo tsa hypoglycemic ka kalafo ea insulin ka bobeli nakong ea kemaro e reriloeng, le hore na ho ima ho etsahetse ha u ntse u sebelisa moriana.

Ho anyesa
Ka ho nahana ka ho haella ha tlhaiso-leseling mabapi le tšebeliso ea gliclazide ka lebese la matsoele le kotsi ea ho ba le neonatal hypoglycemia, letsoele le hanyetsoa nakong ea kalafo ea lithethefatsi.

TLHALOSO LE PUSO

LITLHAKU TSE BUANG HO SEBELISOA FEELA HO BULETSA BATSOALI.

Tekanyetso e khothalletsoang e lokela ho nooa ka molomo, nako e le 'ngoe ka letsatsi, haholo-holo nakong ea lijo tsa hoseng.
Tekanyetso ea letsatsi le letsatsi e ka ba 30-120 mg (1 /₂ - matlapa a 2) ka tekanyetso e le 'ngoe.
Ho khothalletsoa ho metsa letlapa kapa halofo ea letlapa lohle ntle le ho hlafuna kapa ho silafatsa.
Haeba u fetoa ke tekanyetso e le 'ngoe kapa tse' maloa tsa moriana, u ke ke ua nka tekanyetso e phahameng ho lethal e latelang, tekanyetso e lahlehileng e lokela ho nooa ka le hlahlamang.
Joalo ka lithethefatsi tse ling tsa hypoglycemic, lethal dose la lithethefatsi boemong ka bong le tlameha ho khethoa ka bonngoe, ho latela bongata ba glucose ea mali le HbA1c.

Tekanyetso ea pele
Tekanyetso ea pele e khothalletsoang (ho kenyeletsoa bakuli ba tsofetseng, ≥ lilemo tse 65) ke 30 mg ka letsatsi (1 /₂ lipilisi).
Tabeng ea taolo e lekaneng, sethethefatsi tekanyetso ena se ka sebelisoa bakeng sa kalafo ea tlhokomelo. Ka taolo e sa lekaneng ea glycemic, tekanyetso ea letsatsi le letsatsi ea lithethefatsi e ka eketseha ka tatellano ho isa ho 60, 90 kapa 120 mg.
Keketseho ea lethal dose e khonahala eseng pele ho khoeli ea 1 ea kalafo ea lithethefatsi ka tekanyetso e boletsoeng esale pele. Mokhelo ke bakuli bao khatello ea bona ea tsoekere ea mali e sa fokotsehang kamora libeke tse peli tsa kalafo. Maemong a joalo, tekanyetso e ka eketseha libeke tse 2 kamora ho qala tsamaiso.
Tekanyo e phahameng ka ho fetisisa e khothalletsoang ea letsatsi le letsatsi ea lithethefatsi ke 120 mg.
Letlapa le le leng la lithethefatsi la Diabeteson ® MV le tokiso e fetotsoeng ea 60 mg e lekana le matlapa a mabeli a matlapa a Diabeteson ® MV ka tokollo e fetotsoeng ea 30 mg Ho ba teng ha notch litafoleng tsa 60 mg ho u lumella ho arola letlapa le ho nka tekanyetso ea letsatsi le letsatsi ea 30 mg (1 /₂ matlapa a 60 mg), mme haeba ho hlokahala 90 mg (1 le 1/1 /₂ Matlapa a 60 mg).

Phetoho ea ho nka lithethefatsi tsa Diabeteson ® matlapa a 80 mg ho ea lithethefatsi tsa "Diabeteson" V MV ka tokollo e fetotsoeng ea 60 mg Letlapa le le leng la lithethefatsi Diabeteson ® 80 mg le ka nkeloa sebaka 1 /₂ matlapa a nang le tlhahiso ea tsoekere ea Diabeteson ® MV 60 mg. Ha u fetisetsa bakuli ho tloha ho Diabeteson ® 80 mg ho Diabeteson ® MV, ho kgothaletswa taolo ea glycemic ka hloko.

Ho fetoha ho nka sethethefatsi se seng sa "hypoglycemic" ho ea ho lithethefatsi tsa Diabeteson ® MV ka tokollo e fetotsoeng ea 60 mg
Litafole tsa Diabeteson ® MV tsa lithethefatsi tse nang le tlhahiso e fetotsoeng ea 60 mg li ka sebelisoa sebakeng sa lithethefatsi tse ling tsa hypoglycemic bakeng sa tsamaiso ea molomo. Ha u fetisetsa bakuli ba fumanang lithethefatsi tse ling tsa hypoglycemic bakeng sa tsamaiso ea molomo ho Diabeteson ® MV, tekanyo ea bona le halofo ea bophelo e lokela ho ananeloa. Ha e le molao, nako ea phetoho ha e hlokehe. Tekanyetso ea pele e lokela ho ba 30 mg mme ebe ea kenngoa ka bongata ho latela bongata ba tsoekere ea mali.
Ha lefu la tsoekere la Diabeteson ® MV le nkeloa sebaka ke lipolao tsa sulfonylurea nako e telele ea halofo ea bophelo ho qoba hypoglycemia e bakoang ke ts'usumetso e eketsang ea liakhente tse peli tsa hypoglycemic, o ka emisa ho li nka matsatsi a 'maloa. Tekanyetso ea pele ea lithethefatsi Diabeteson ® MV le eona e na le 30 mg (1 /₂ matlapa a 60 mg) mme, haeba ho hlokahala, a ka eketsoa nakong e tlang, joalo ka ha ho hlalositsoe kaholimo.

Tšebeliso e kopantsoeng le moriana o mong oa hypoglycemic
Diabeteson ® MV e ka sebelisoa hammoho le biguanidins, alpha-glucosidase inhibitors kapa insulin. Ka taolo e sa lekaneng ea glycemic, kalafo e eketsehileng ea insulin e lokela ho beoa ka tlhahlobo e hlokolosi ea bongaka.

Bakuli ba baholo
Phetoho ea khaba bakeng sa bakuli ba lilemo tse fetang 65 ha e ea hlokahala.

Bakuli ba nang le ho hloleha ha meno
Liphetho tsa lithuto tsa kliniki li bonts'itse hore phetoho ea lethal dose ho bakuli ba nang le phofshoana ea ho hlaphoheloa ha ausi ha e hlokehe. Ho hlahlojoa tlhokomelo ea bongaka e haufi.

Bakuli ba Kotsi ea Hypoglycemia
Ho bakuli ba kotsing ea ho ba le hypoglycemia (phepo e sa lekaneng kapa e sa leka-lekanang, mathata a endocrine a matla kapa a sa fumaneng hantle - ho hloka tlhokomelo ea boemo bo holimo le lefu la ho hloleha ho phekola maloetse (glucocorticosteroids (GCS) kamora ts'ebeliso e telele le / kapa tsamaiso litekanyetso tse phahameng, lefu la pelo le matla haholo. tsamaiso ea methapo ea methapo - lefu le matla la pelo, lefu le matla la carotid, lefu le tloaelehileng la tšebetso ea methapo), ho khothalletsoa ho sebelisa lethalinyana (30 mg) la prep Ata Diabeton ® MV.

Thibelo ea mathata a lefu la tsoekere
Ho fihlella taolo e matla ea glycemic, butle-butle o ka eketsa tekanyetso ea lithethefatsi Diabeteson ® MV ho isa ho 120 mg / letsatsi ho kenyelletsa lijo le ho ikoetlisa ho fihlela boemo ba sepheo sa HbA1c. Hopola kotsi ea ho ba le hypoglycemia. Ntle le moo, lithethefatsi tse ling tsa hypoglycemic, mohlala, metformin, alpha-glucosidase inhibitor, thiazolidinedione derivative kapa insulin, li ka eketsoa ho tsa bongaka.

Bana le bacha ba ka tlase ho lilemo tse 18.
Lintlha tse mabapi le katleho le polokeho ea lithethefatsi ho bana le bacha ba ka tlase ho lilemo tse 18 ha li fumanehe.

PUSELETSO MAHALA
Ka lebaka la boiphihlelo ka gliclazide, o lokela ho hopola ka monyetla oa ho nts'etsapele litlamorao tse latelang.

Hypoglycemia
Joalo ka lithethefatsi tse ling tsa sehlopha sa sulfonylurea, lefu la tsoekere la Diabeteson ® MV le ka baka hypoglycemia haeba ho ka ba le lijo tse seng molaong, haholoholo haeba lijo li sa fumanehe. Matšoao a ka bang teng a hypoglycemia: ho opeloa ke hlooho, tlala e matla, ho nyekeloa, ho felloa ke matla, ho tšoenyeha ha boroko, ho teneha, ho fokotseha ha tlhokomelo, ho lieha ho arabela, khatello ea maikutlo, pherekano, pono e sa hlakang le puo, aphasia, ho thothomela, paresis, tahlehelo ea boitšoaro , maikutlo a ho hloka thuso, pono e sa tsitsang, ho tsekela, ho fokola, ho tsitsipana, bradycardia, delirium, ho hema ka thata, ho otsela, ho felloa ke letsoalo ka ho khona ho holofala ho fihlela lefung.
Boitšoaro ba Andrenergic bo ka boela ba hlokomeleha: mofufutso o eketsehileng, letlalo "letheba", ho tšoenyeha, tachycardia, khatello e phahameng ea mali, palpitations, arrhythmia, le angina pectoris.

Ha e le molao, matšoao a hypoglycemia a emisoa ka ho nka limatlafatsi (tsoekere). Ho nka li-sweeteners ha ho na thuso. Khahlano le semelo sa tse ling tse tlisoang ke sulfonylurea, liphapang tsa hypoglycemia li ile tsa lemohuoa kamora phomolo e atlehileng.

Ho hypoglycemia e matla kapa ea nako e telele, ho bontšoa tlhokomelo ea bongaka ea tšohanyetso, mohlomong ka ho kena sepetlele, le haeba ho e-na le phello ea ho nka lik'habohaedreite.

Litla-morao tse ling

Ho tsoa pampiring ea ka mpeng: bohloko ba ka mpeng, ho nyekeloa, ho hlatsa, lets'ollo, ho sokela. Ho nwa moriana nakong ea lijo tsa hoseng ho qoba matšoao ana kapa ho a fokotsa.

Litlamorao tse latelang ha li sa tloaeleha:

Ka lehlakoreng la letlalo le lisele tse nyane: lekhopho, ho hlohlona, ​​urticaria, edema ea Quincke, erythema, makhopho a maculopapular, maikutlo a lipolao (joalo ka Stevens-Jones syndrome le necrolysis e nang le chefo).

Ho tsoa lithong tsa hemopoietic le li-lymphatic system: maloetse a hematological (anemia, leukopenia, thrombocytopenia, granulocytopenia) ha a na seoelo. Joaloka molao, liketsahalo tsena lia fetoha haeba phekolo e khaotsa.

Ka lehlakoreng la sebete le pampitšana ea biliary: ts'ebetso e eketsehileng ea li-enzymes tsa "sebete" (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (linyeoe tse ikhethileng). Haeba choleundatic jaundice e etsahala, phekolo e lokela ho khaotsa.

Lintho tsena hangata lia fetoha haeba phekolo e khaotsa.

Ho tloha lehlakoreng la setho sa pono: litšitiso tsa nakoana tsa pono li ka hlaha ka lebaka la phetoho ea khatello ea tsoekere ea mali, haholoholo qalong ea kalafo.

Litla-morao tse fumanehang ho sulfonylurea derivatives: joalo ka litlamorao tse ling tsa sulfonylurea, ho ile ha hlokomeloa litla-morao tse latelang: erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, allergic vasculitis, hyponatremia. Ho bile le keketseho ea ts'ebetso ea li-enzyme tsa "sebete", ts'ebetso ea ho se sebetse hantle ha sebete (mohlala, ka nts'etsopele ea cholestasis le jaundice), lipontšo li ile tsa fokotseha ka mor'a nako kamora ho khaotsa litokisetso tsa sulfonylurea, empa maemong a mang ho lebisitse ho se atleheng ha sebete.

Litla-morao tse lemohileng litekong tsa bongaka
Phuputsong ea ADVANCE, ho bile le phapang e nyane khafetsa ea liketsahalo tse mpe tse mpe tse mpe lipakeng tsa lihlopha tsena tse peli tsa bakuli. Ha ho lintlha tse ncha tsa polokeho tse fumanoeng. Palo e fokolang ea bakuli e ne e e-na le hypoglycemia e matla, empa kakaretso ea hypoglycemia e ne e le tlase. Kotsi ea hypoglycemia sehlopheng se matla sa taolo ea glycemic e ne e phahame ho feta sehlopheng se laoloang ke glycemic. Likarolo tse ngata tsa hypoglycemia sehlopheng se matla sa taolo ea glycemic li ile tsa bonoa khahlano le semelo sa phekolo ea insulin.

PUSELETSO
Haeba ho na le lithethefatsi tse ngata tse tsoang ho sulfonylurea, ho ka hlaha hypoglycemia.
Haeba u ba le matšoao a bobebe a hypoglycemia ntle le ho lemala kapa matšoao a methapo, o lokela ho eketsa tekanyo ea lik'habohaedreite ka lijo, fokotsa tekanyo ea lithethefatsi le / kapa ho fetola lijo. Tlhahlobo ea bongaka ea haufi le boemo ba mokuli e lokela ho tsoela pele ho fihlela ho ba le tšepo ea hore ha ho na letho le sokelang bophelo ba hae. Mohlomong nts'etsopele ea maemo a matla a hypoglycemic, e tsamaeang le komisi, ho akheha kapa mathata a mang a methapo ea methapo. Haeba matšoao a joalo a hlaha, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka le ho kena sepetlele hang-hang.
Maemong a coma ea hypoglycemic kapa haeba ho belaelloa, mokuli o kenngoa kahare kahare le 50 ml ea tharollo ea 20-30% ea dextrose (glucose). Ebe tharollo ea 10% ea dextrose e tsamaisoa ka mokhoa o tlohang ho boloka khatello ea tsoekere ea mali ka holimo ho 1 g / L. Ho lekola ka hloko maemo a tsoekere ea mali le ho hlahloba mokuli ho lokela ho etsoa bonyane lihora tse 48 tse latelang. Kamora nako ena ea nako, ho latela boemo ba mokuli, ngaka e eang e nka qeto ea tlhoko ea tlhahlobo e ngoe hape. Ho buoa ka methapo ha ho na thuso ka lebaka la ho tlangoa ha gliclazide liprotheine tsa plasma.

KAMANO LE LITLHAKISO TSE LING

1) Lithethefatsi le lintho tse eketsang kotsi ea hypoglycemia:
(ho ntlafatsa phello ea gliclazide)

Motsoako o kopantsoeng
- Miconazole .

Ha e khothalletsoe motsoako
- Phenylbutazone .
Ho molemo ho sebelisa sethethefatsi se seng se thibelang mafu. Haeba phenylbutazone e hlokahala, mokuli o lokela ho lemosoa ka tlhokahalo ea taolo ea glycemic. Haeba ho hlokahala, tekanyetso ea lithethefatsi Diabeteson ® MV e lokela ho fetoloa ha o ntse o nka phenylbutazone le kamora eona.
- Ethanol : e ntlafatsa hypoglycemia, e thibela ts'usumetso ea maikutlo, e ka kenya letsoho kholisong ea komello ea hypoglycemic. Hoa hlokahala ho hana ho nka meriana, e kenyang ethanol le lino tse tahang.

Litlhokomelo
Glyclazide e kopantsoeng le lithethefatsi tse ling: li-antibigener tse ling tsa hypoglycemic (insulin, acarbose, metformin, thiazolidinidiones, dipeptidyl peptidase-4 inhibitors, GLP-1 agonists), li-agents tsa thibelo ea adrenergic, fluconazole, angiotensin-antiplatelet inhibitors, caprimentin-antiplatelet inhibitors₂Li-receptor tsa histamine, li-inhibitors tsa monoamine oxidase, sulfonamides ,cacithromycin le lithethefatsi tse seng khahlanong le ho ruruha tsa cellidal) li tsamaisana le keketseho ea phello ea hypoglycemic le kotsi ea hypoglycemia.

2) Lithethefatsi tse eketsang tsoekere ea mali:
(phello e fokotsang ea gliclazide)

- Danazole: e na le lefu la tsoekere. Haeba ho sebelisa sethethefatsi sena hoa hlokahala, mokuli o eletsoa hore a lekole tsoekere ea mali ka hloko. Haeba ho hlokahala, tsamaiso e kopanetsoeng ea lithethefatsi, ho khothalletsoa hore tekanyetso ea moemeli oa hypoglycemic e khethoe ka bobeli nakong ea tsamaiso ea danazol le ka mor'a ho tlohela.

Litlhokomelo
- Chlorpromazine (antipsychotic) : tekanyetso e phahameng (tse fetang 100 mg ka letsatsi) e eketsa tsoekere e maling, e fokotsa sekhahla sa insulin.
Ho khothalletsoa taolo ea glycemic ka hloko. Haeba ho hlokahala, tsamaiso e kopanetsoeng ea lithethefatsi, ho khothalletsoa hore ho khethoe lethaliti la moemeli oa hypoglycemic, ka bobeli nakong ea tsamaiso ea antipsychotic le ka mor'a ho tlohela.
- GKS (Ts'ebetso ea kemiso le ea lehae: intraarticular, letlalo, tsamaiso ea rectal) le tetracosactide: eketsa bongata ba tsoekere ea mali ka nts'etsopele ea ketoacidosis (ho fokotseha ha mamello ho lik'habohaedreite). Ho laoloa ka hloko glycemic, haholo-holo qalong ea kalafo. Haeba ho hlokahala hore ho sebelisoe lithethefatsi mmoho, phetoho ea moemeli ea hypoglycemic e ka hlokahala ka bobeli nakong ea tsamaiso ea GCS le kamora ho itokolla.
- Ritodrin, salbutamol, terbutaline (Tsamaiso ea methapo): aga-2 adrenergic agonists e eketsa khatello ea tsoekere ea mali.
Ho lebisoa tlhokomelo e khethehileng ho bohlokoa ba taolo ea glycemic. Haeba ho hlokahala, ho khothalletsoa ho fetisetsa mokuli kalafo ea insulin.

3) Metsoako e lokelang ho ananeloa

- Li-Anticoagulants (mohlala warfarin)
Liphetho tsa sulfonylureas li ka ntlafatsa phello ea li-anticoagulants ha li kopane. Ho ka 'na ha hlokahala hore u ntlafatse tokiso ea litheko tsa anticoagulant.

TLHOKOMELISO LITLHAKISO

Hypoglycemia
Ha u nka lintho tse tsoang ho sulfonylurea, ho kenyelletsa le gliclazide, hypoglycemia e ka hlaha, maemong a mang e le ka sebopeho se matla le sa nako e telele, se hlokang ho kena sepetlele le tsamaiso e matla ea tharollo ea dextrose ka matsatsi a 'maloa (bona karolo ea "Litla-morao".
Setlhare se ka fuoa feela bakuli bao lijo tsa bona li leng teng khafetsa 'me li kenyelletsa lijo tsa hoseng. Ho bohlokoa haholo ho boloka phepelo e lekaneng ea lik'habohaedreite ka lijo, kaha menyetla ea ho ba le hypoglycemia e eketseha ka phepo e sa lekanyetsoang kapa e sa lekaneng, hammoho le ha o ja lijo tse se nang mafura a lik'habohaedreite.
Hypoglycemia hangata e hlaha ka ho ja lijo tse nang le khalori e tlase, ka mor'a ho ikoetlisa ka nako e telele kapa ka matla, ka mor'a ho noa joala, kapa ha u sebelisa lithethefatsi tse 'maloa tsa hypoglycemic ka nako e le' ngoe.
Ka tloaelo, matšoao a hypoglycemia a nyamela kamora ho ja lijo tse nang le lik'habohaedreite tse ngata (tse kang tsoekere). Re lokela ho hopola hore ho nka li-sweeteners ha ho thusa ho tlosa matšoao a hypoglycemic. Phihlelo ea ho sebelisa litlatsetso tse ling tsa sulfonylurea e fana ka maikutlo a hore hypoglycemia e ka khutla le ha boemo bona bo ka ba bonolo. Ketsahalong eo matšoao a hypoglycemic a boleloang kapa a boletsoeng ka nako e telele, le maemong a ntlafatso ea nakoana kamora ho ja lijo tse nang le lik'habohaedreite, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka, ho fihlela sepetlele.
Bakeng sa ho qoba kholo ea hypoglycemia, ho hlokahala hore motho a khethe lithethefatsi le mofuta oa kalafo ka hloko hammoho le ho fa mokuli tlhaiso-leseling e felletseng ka kalafo.

Kotsi e eketsehileng ea hypoglycemia e ka hlaha maemong a latelang:

• ho hana kapa ho se khonehe ha mokuli (haholo-holo batho ba baholo) ho latela litaelo tsa ngaka le ho hlokomela boemo ba hae,
• phepo e sa lekaneng le e sa sebetseng, ho tlōla lijo, ho itima lijo le ho fetola lijo,
• ho se lekane pakeng tsa ts'ebetso ea 'mele le palo ea lik'habohaedreite tse nkiloeng,
• ho hloleha ha rems
• ho hloleha ho matla ha sebete
• overdose of the drug Bareken ® MV,
• mathata a mang a endocrine: lefu la qoqotho, ho hloleha ha sethoathoa le ho hlaka,
• tšebeliso e tšoanang ea lithethefatsi tse ling (bona karolo "Ho sebelisana le lithethefatsi tse ling").

Ho hloleha ha letsoalo le sebete
Ho bakuli ba nang le hepatic le / kapa ho se sebetse hantle haholo ka mpeng, pharmacokinetic le / kapa li-pharmacodynamic thepa ea gliclazide e ka fetoha. Boemo ba hypoglycemia bo hlahang ho bakuli ba joalo bo ka ba telele haholo, maemong a joalo, ho hlokahala kalafo e loketseng hanghang.

Tlhahisoleseling ea mokuli
Hoa hlokahala ho tsebisa mokuli, hammoho le litho tsa lelapa la hae, ka kotsi ea ho ba le hypoglycemia, matšoao a eona le maemo a tsamaisanang le kholo ea eona. Mokuli o tlameha ho tsebisoa ka likotsi le melemo ea kalafo e boletsoeng.
Mokuli o hloka ho hlakisa bohlokoa ba ho ja, tlhoko ea ho ikoetlisa khafetsa le ho lekola likhahla tsa tsoekere ea mali.

Taolo e sa lekanang ea glycemic
Taolo ea glycemic ho bakuli ba fumanang kalafo ea hypoglycemic e kanna ea fokola maemong a latelang: feberu, ho sithabela maikutlo, lefu le tšoaetsanoang, kapa ho buuoa ho hoholo. Ka maemo ana, ho ka 'na ha hlokahala hore u khaotse ho phekoloa ka moriana oa Diabeteson ® MV le ho fana ka kalafo ea insulin.
Ho bakuli ba bangata, katleho ea li-antic hypoglycemic agents, ho kenyelletsa le gliclazide, e fokotseha ka mor'a nako e telele ea kalafo. Tšusumetso ena e ka bakoa ke ho tsoela pele ha lefu lena le ho fokotseha ha karabelo ea kalafo ho moriana. Ketsahalo ena e tsejoa e le ho hanyetsa lithethefatsi tsa bobeli, tse lokelang ho khetholloa ho ea mantlha, moo moriana o sa feng phello e lebelletsoeng ea kliniki nakong ea kopano ea pele. Pele o tseba mokuli ka khatello ea bobeli ea lithethefatsi, ho hlokahala hore ho hlahlojoe ho lekana ha khetho ea lethal dose le ho lumellana le mokuli ka lijo tse boletsoeng.

Liteko tsa Lab
Ho hlahloba taolo ea glycemic, ho khothalletsoa boikemisetso ba ho itima lijo ka bongata ba glucose le hemoglobin HbA1c.
Ntle le moo, ho bohlokoa hore nako le nako u itlhahlobe ho tsepamisang mahlo tsoekere ea mali.
Lintho tse tsoang ho Sulfonylurea li ka baka anemia ea hemolytic ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase. Kaha gliclazide ke sulfonylurea e tsoang ho eona, tlhokomelo e lokela ho nkuoa ha e e fuoa ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase.
Monyetla oa ho hlahisa moriana oa hypoglycemic oa sehlopha se seng o lokela ho hlahlojoa.

HO SIRELETSA TEMOHO HO HLOMPHA LITLHAKISO TSA METSOALLE LE METSOALLE
Ka lebaka la nts'etsopele ea hypoglycemia ka tšebeliso ea lithethefatsi Diabeteson ® MV, bakuli ba lokela ho hlokomela matšoao a hypoglycemia mme ba lokela ho ba hlokolosi ha ba khanna makoloi kapa ba etsa mosebetsi o hlokang lebelo le leholo la karabelo ea mmele le kelello, haholo qalong ea kalafo.

TLHOKOMELISO MOTSAMAI
Matlapa a lokolotsoeng a 60 mg
Matlapa a 30 ka blister e le 'ngoe (PVC / Al), maleiri a le 1 kapa a mabeli a nang le litaelo tsa tšebeliso ea bongaka ka har'a pakete ea karete.
Ha ho paka (ho paka) k'hamphaning ea Marang-rang ea Sensource ea Russia:
Matlapa a 30 ka blister e le 'ngoe (PVC / Al), maleiri a le 1 kapa a mabeli a nang le litaelo tsa tšebeliso ea bongaka ka har'a pakete ea karete.
Matlapa a 15 ka blister e ngoe le e ngoe (PVC / Al), maleiri a mabeli kapa a mane a nang le litaelo tsa tšebeliso ea bongaka ka har'a pakete ea karete.
Ka tlhahiso khoebong ea khoebo ea Russia Serdix
Ho na le matlapa a 15 ka blister e le 'ngoe ea PVC / Al. Bakeng sa maleiri a mabeli kapa a mane a nang le litaelo tsa tšebeliso ea bongaka ka paketeng ea karete.

MAHLOMPHO MOTS'ELISO
Ho hlokahala maemo a khethehileng a polokelo.
Qoba hole le bana.

BOPHELO SHELF
Lilemo tse 2 Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

TS'ELISO MAHALA
Ka lengolo la ngaka.

MOEKETSI MOTSAMAI
Indasteri ea Basebetsi ea Mosebetsi oa Basebetsi, Fora
Serdix LLC, Russia

Setifikeiti sa ngoliso se fanoeng ke li-Labour Labouries, Fora;

"Indasteri ea Basebeletsi ba Laborator":
905, tsela e kholo ea Saran, 45520 Gidey, Fora
905, tsela de Saran, 45520 Gidy, France

Bakeng sa lipotso tsohle, ikopanye le Ofisi ea Moemeli oa JSC "Worker's Laborator".

Phatlalatso ea "Mosebeletsi oa Laborator":
115054, Moscow, Paveletskaya pl. d.2, leq. 3

Tabeng ea ho paka le / kapa ho paka / ho e hlahisang ho LLC Serdiks, Russia
Serdix LLC:
Russia, Moscow

Diabeteson MV: litaelo tsa tšebeliso (litekanyetso le mokhoa)

Setlhare se nooa ka molomo, hanngoe ka letsatsi (haholo-holo nakong ea lijo tsa hoseng). Ha ho khothalletsoe ho sila kapa ho hlafuna letlapa.

Tekanyetso ea letsatsi le letsatsi ea lefu la tsoekere ea MV e fapana ho tloha ho 30 ho isa ho 120 mg ka tekanyetso e le 'ngoe. Haeba u hloloheloa letsatsi le le leng kapa a mangata a kalafo, u ke ke ua eketsa lethal dose ho tse latelang.

Tekanyo ea lithethefatsi e khethoa ka bonngoe ho latela matšoao a joalo ka khatello ea tsoekere maling le boemo ba glycogemoglobin (HbA1c).

Qalong ea kalafo, Diabeteson MV 30 mg ka letsatsi e behiloe (ho kenyelletsa bakuli ba tsofetseng ba lilemo li 65 le ho feta). Ka taolo e lekaneng, gliclazide ho lethal dose lena e ka sebelisoa e le pheko ea tlhokomelo. Tabeng ea taolo e sa lekaneng ea glycemic, lethalamo le ka eketsoa (ka tatellano) ho isa ho 60 mg, 90 mg kapa 120 mg ka letsatsi.

Tekanyetso e ka eketsoa kamora khoeli e le 'ngoe ea kalafo le gliclazide ka tekanyetso e boletsoeng esale pele, ntle le bakuli bao boemo ba tsoekere ea mali bo sa fokotseheng kamora libeke tse peli ba sebelisitse moriana. Bakuli ba joalo ba ka eketsa lethal dose kamora libeke tse peli tsa kalafo.

Tekanyo e kholo ea Diabeteson MV ke 120 mg ka letsatsi.

Ha o fetoha ho tloha lithethefatsi Diabeteson (80 mg ea gliclazide) ho Diabeteson MV, letlapa le le leng la Diabeteson le fetoha halofo ea letlapa la Diabeteson MV 60 mg. Phetoho e etsoa tlasa taolo ea glycemic e hlokolosi.

Diabeteson MV e ka nkuoa ho fapana le li-agents tse ling tsa molomo tsa hypoglycemic. Ha ho fetisetsoa mokuli, lethal dose ea sethethefatsi se sebelisitsoeng sa hypoglycemic le halofo ea bophelo ba sona ea tsotelloa. Hangata ha ho hlokahale nako ea phetoho. Tekanyetso ea pele ea Diabeteson MV ke 30 mg mme ka mor'a moo e kengoa ho latela boemo ba glucose maling.

Haeba mokuli a nkile mefuta e meng ea sulfonylurea e tlohang halofo ea bophelo, ho hlokahala ho emisa kalafo ka matsatsi a 'maloa mme kamora hore a qale ho nka Diabeteson MV (ho thibela hypoglycemia, e ka hlahisoang ke litlamorao tsa lithethefatsi tse peli tsa hypoglycemic).

Gliclazide e ka kopanngoa le alpha-glucosidase inhibitors, insulin kapa biguanidines.

Tabeng ea taolo e sa lekaneng ea glycemic, kalafo ea insulin e etsoa ka nako e ts'oanang tlasa tlhokomelo ea bongaka e haufi.

Bakeng sa bakuli ba lilemo li 65 le ho feta, hammoho le bakuli ba nang le bothata bo fokolang ba ho leka-lekanya ha a hloke phetoho.

Ha ho na le li-contraindication tse amanang, Diabeteson MV e sebelisoa ka tekanyetso e nyane e khothalletsoang (30 mg ka letsatsi).

Litlamorao

• tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, bohloko ba ka mpeng, ho hlatsa, ho sokela kapa ho ts'oaroa (ho nka gliclazide nakong ea lijo tsa hoseng ho fokotsa monyetla oa ho ba le matšoao ana),
• sebete le pampiri ea biliary: tšebetso e eketsehang ea transaminase ea sebete, linyeoe tse ikhethileng - hepatitis (ho khaola kalafo hoa hlokahala),
• tsamaiso ea lymphatic le hematopoietic litho: ka seoelo - leukopenia, anemia, granulocytopenia, thrombocytopenia (nyamela ka mor'a ho khaotsa lithethefatsi),
• Letlalo le mafura a ikhethileng: ho hlohlona letlalo, erythema, lekhopho, urticaria, lekhopho la maculopapular, angioedema, ts'ebetso ea likholi.
• litho tsa kutlo: ho ferekana ha nakoana ka lebaka la liphetoho tsa maemo a tsoekere, haholoholo qalong ea kalafo.

Nakong ea phekolo le Diabeteson MV, hypoglycemia e ka hlaha, haholo-holo ka lijo tse sa tloaelehang kapa ho tlōla lijo tsa hoseng, lijo tsa motšeare kapa lijo tsa mantsiboea. Matšoao a hypoglycemia ke: ho nyekeloa pelo, tlala e matla, ho hlatsa, ho opeloa ke hlooho, ho teneha, ho fokotseha ha nako, ho tepella, ho ferekana, ho arabela butle, ho ferekana ha boroko, pherekano, ho thothomela, maikutlo a ho hloka thuso, khatello ea maikutlo, puo e sa sebetseng hantle le pono. khatello ea maikutlo, paresis, tsieleho ea kelello, ho akheha, aphasia, bradycardia, phefumoloho e sa tebang, ho tsekela, ho fokola, ho otsela, ho otsela, ho lahleheloa ke letsoalo, ho akheha (ho fihlela lefung). Litlamorao tse latelang tsa adrenergic li ka boela tsa hlaha: ho tšoenyeha, hyperhidrosis, tachycardia, palpitations, angina pectoris, ho tiea ha letlalo, khatello e eketsehileng ea mali le arrhasmia.

Hangata, matšoao a hypoglycemia a emisoa ka katleho ke ho ja tsoekere (lik'habohaedreite). Li-sweeteners ha li na thuso. Haeba kamora ho phomola ka katleho hypoglycemia mokuli a nka lintho tse ling tse tsoang ho sulfonylurea, a ka khutla hape a ka mpefala hape. Tabeng ea hypoglycemia ea nako e telele kapa e matla, ho khothaletsoa tlhokomelo ea tšohanyetso (ho fihlela sepetlele), leha e le ka ho phomola matšoao ka ho itaola lik'habohaedreite.

Ka nako e 'ngoe lithethefatsi li ka baka litlamorao tse latelang tse tsoang ho tsohle tse fumanoeng sulfonylurea: hemolytic anemia, erythrocytopenia, pancytopenia, hyponatremia, agranulocytosis, allergic vasculitis.

Litaelo tse khethehileng

Diabeteson MV e ka fuoa feela bakuli ba sa pheheng lijo mme ba lula ba e-ja lijo tsa hoseng. Ho bohlokoa ho boloka lijo tse nang le lik'habohaedreite ka bongata lijong le ho qoba lijo tse nang le carb e tlase. Kotsi ea hypoglycemia e eketseha maemong a latelang:

• ho hloleha ho matla ha sebete
• ho hloleha ha rems
• ho ba teng ha maloetse a mang a endocrine (adrenal and pituitary insuffence, lefu la qoqotho),
• phepo e sa tloaelehang le e fosahetseng, ho itima lijo, ho tlōla lijo, ho fetola lijo,
• ho se leka-lekane pakeng tsa palo ea lik'habohaedreite tse fanoang ke lijo le tšebetso ea 'mele,
• tšebeliso e le 'ngoe ea lithethefatsi tse itseng (bona karolo e "Karolo ea Lithethefatsi"),
• overdose ea gliclazide,
• ho se khone kapa ho hana ha mokuli (haholo-holo botsofaling) ho laola boemo ba hae le ho latela litaelo tsa ngaka.

Ho fokola ha taolo ea glycemic ho lumelloa ho bakuli ba nang le likotsi, ts'ebetso e kholo ea ho buoa, mafu a tšoaetsanoang kapa feberu. Maemong ana, ho ka hlokahala ho tlosoa ha Diabeteson MV le tsamaiso ea insulin.

Ho bakuli ba bangata, katleho ea li-hypoglycemic agents bakeng sa tsamaiso ea molomo e ka fokotseha ha nako e ntse e feta (seo ho thoeng ke sekhahla sa lithethefatsi sa bobeli).

Ho sebelisana le lithethefatsi

Kameho ea gliclazide e ntlafatsoa ka tšebeliso e ts'oanang le miconazole (motsoako ona o kopantsoe, kaha o ka lebisa nts'etsopele ea komisi), phenylbutazone le ethanol (phello ea hypoglycemic e ntlafalitsoe).

Ka lebaka la kotsi ea hypoglycemia, Diabeteson MV e lokela ho sebelisoa ka hloko le lithethefatsi tse latelang: li-hypoglycemic agents (acarbose, insulin, thiazolidinediones, metformin, dipeptidyl peptidase-4 inhibitors), fluconazole, beta-adrenergic blocker agents, sulfonamides, angiotensin capinclinpsinepinininselin, capioteininepinseinselin, lingiepensinepensinepensinepensinepinoteinerinselinininensinensin, capi lithethefatsi tse khahlanong le ho ruruha, histamine H blockers₂li-receptors, monoamine oxidase inhibitors.

Matla a gliclazide a fokolisa danazol (motsoako ona ha o khothalletsoe), chlorpromazine, glucocorticosteroids ka nako e ts'oanang le tetracosactide le beta₂-adrenomimetics. Lithethefatsi tsena li sebelisoa ka hlokolosi hape li le taolong e haufi ea glycemic.

Gliclazide e ka ntlafatsa phello ea li-anticoagulants.

Litšoantšiso tsa Diabeteson MV ke Gliclazide MV, Gliclazide-AKOS, Gliclazide Canon, Gliclazide MV Pharmstandard, Golda MV, Glidiab, Gliklada, Diabetalong, Glidiab MV, Diabefarm, Glyclazid-SZ, Diabinax, Diabefarm MV, jj.

Litlhahlobo mabapi le Diabeteson MV

Bakuli ba siea litlhahlobo tse ntle haholo ka Diabeteson MV. Ena ke setlhare se sebetsang hantle se thusang ho boloka maemo a tloaelehileng a tsoekere ea mali. Gliclazide ke ka seoelo e bakang lintho tse kulang le litlamorao tse ling. Ho loketse ho nka matlapa, kaha tekanyetso ea letsatsi le letsatsi e etselitsoe tekanyetso e le 'ngoe. Phekolo le Diabeteson MV ke mokhoa o mong o loketseng kalafo ea insulin.

Tšebeliso ea lithethefatsi, ho latela bakuli: tlhoko ea ts'ebeliso e tsoelang pele, e ke ke ea fuoa bana, kotsi ea hypoglycemia, litšenyehelo tse phahameng, karabelo ea motho ka mong ho gliclazide.