Mildronate ea lithethefatsi: litaelo tsa tšebeliso

"Meldonium" ntle le tšabo e ka kopanngoa le lithethefatsi tse ntlafatsang microcirculation. Ntle le moo, moriana ona o tsamaisana le pelo glycosides, nitrate e sebetsang ka nako e telele.

Moriana ona o ntlafatsa ts'ebetso ea li-vasodilators, li-adrenergic blockers. E lumellana hantle le lithethefatsi bakeng sa kalafo ea AIDS.

Ha e khothalletsoe ho kopanya le lithethefatsi tse thehiloeng ho cyclophosphamide le ifosfamide ka lebaka la kotsi ea cardiotoxicity. Ntle le moo, ha ho khothalletsoe ho sebelisa meriana e meng e thehiloeng ho meldonium ka nako e le 'ngoe, ka lebaka la kotsi e eketsehileng ea ho ba le liketsahalo tse bohloko.

Lithethefatsi tse nang le karolo e tšoanang e sebetsang ka sebopeho li bitsoa li-analogues. Lipakeng tsa bona, li fapana ka mabitso a khoebo, khamphani ea tlhahiso, eo hangata e leng litheko le boleng.

Har'a tse ling tsa "Meldonium" ke litokisetso: "Mildronate", "lipalesa", "Metamax", "Milocard-N", "Vazopro", "Metonat", "Mildrakor". Lefu la tsoekere le lumella tšebeliso ea lingoloa tsohle tsa Meldonium.

Ha ho kgothaletswe ho fetolela meriana ena ka bo bona, ho ka etsahala ho etsa sena feela ka mor'a ho buisana le ngaka ea hau.

Contraindication

Ts'ebeliso ea Mildronate marangrong a bokong le khatello e eketsehileng ea maqhubu ha e khothalletsoe. Ntle le moo, ha ho kgothaletswe ho sebelisa moriana ona kalafong ea maemo a tsamaeang le ho tsoa hoa mofufutso o tsoang lijana tsa bokong.

• ho hloka mamello ho setho se ka sehloohong se sebetsang kapa likarolo tse ling tsa meriana,
• Keketseho e kenang ea hare-hare,
• ts'enyo ea tlhaho
• ho hloleha ho matla ha hepatic le / kapa ho ba le methapo,
• nako ea kemaro
• nako ea kemolo
• bana ba ka tlase ho lilemo tse 18.

Litlhahlobo tse bonolo

Moriana ona ke khale o sebelisoa ho tsa bongaka, ka hona ho na le litlhahlobo tse ngata mabapi le ts'ebetso ea ona.

Igor, ea lilemo li 45, Rostov-on-Don

Kristina, ea lilemo li 38, Vladivostok

E se e le lilemo tse fetang 12 ke ntse ke phekola litlamorao tsa ho otloa ke stroke. Hangata ke fa Mildronate a kula bakuli ba ka. Sesebelisoa sena ha se na thuso bakeng sa bakuli ba nang le khatello e eketsehileng ea intracranial, empa maemong a mang ha e khonehe. E kenya letsoho ho feliseng ka potlako ea liketsahalo tse setseng tsa pathological, tse etsang hore bakuli ba nolofale ho feta nakong ea ntlafatso.

Vladimir, ea lilemo li 43, Murmansk

Moriana o ka ntlafatsa boemo ba lisele tsa pelo tse amehang. Ka lebaka la litlamorao tsa antihypoxic le antioxidant, sesebelisoa sena se thusa ho tsitsisa pelo le ho eketsa ho hanyetsa khatello ea maikutlo le ts'ebetso ea mabaka a fapaneng.

Irina, ea lilemo li 82, Moscow

Igor, ea lilemo li 45, Ryazan

Tlhahlobo ea katleho ea antihypoxic ea meldonium mathateng a microvasculature ho bakuli ba nang le mofuta oa 2 lefu la tsoekere | Likronike

Korpachev V.V., Korpacheva-Zinich O.V., Gurina N.M., Kovalchuk A.V., Kushnareva N.N., Shishkan-Shishova K.A., Nailed O.V.

Lefu la tsoekere ke “bothata bo potlakileng,” ka lebaka la ho ata ha lona, ​​tšekamelo ea ho eketsa palo ea bakuli le ho ba teng ha mathata a sa foleng.

Mosebetsi oa bohlokoa ke nts'etsopele ea mekhoa e mecha ea thibelo le kalafo ea lefu la tsoekere, e reretsoeng ho fokotsa kotsi ea nts'etsopele le nts'etsopele ea mathata a mantlha le a maholo. DM e tšoauoa ka mathata a polymetabolic a koahelang lihokelo tsohle tsa metabolic.

Tlolo ea ts'ebeliso ea likarolo tse kholo tsa matla li tsamaisana le ho fokotseha ha matla a phapanyetsano ea matla, ho fokotseha ha pokello ea likhomphutha tsa macroergic, le keketseho ea litsamaiso tsa mahala tsa phetoho.

Bakuli ba lefu la tsoekere la mofuta oa 2 ba sebakeng sa kotsi ea ho hlaha le ho phahama ha mathata a pelo, a lebisang phetohong ea oxygenation ea litho tsohle le litho.

Haholo-holo, litholoana tsa ischemia ea nako e telele le hypoxia ea litho tse ka tlase tsa maoto ke nts'etsopele ea peripheral diabetesic neuro- le angiopathy.

Karolo ena e bontšoa ke lesapo le kopaneng le akaretsang la methapo ea methapo e mahareng le e kholo (macroangiopathy) le microvasculature (peripheral microangiopathy).

Le ha ho na le liso tsa bohlokoa tsa bongaka tsa likepe tse kholo ho bakuli ba nang le lefu la tsoekere, mathata a tebileng a microcirculation hangata a fumanoa, a tsamaea le liphetoho tsa bohlokoa tsa metabolic. Ka hona, ho tsamaisoa ha oksijene, ho tsamaisoa ha eona le tšebeliso ea lisele ke matšoao a bohlokoa ka ho fetisisa a ts'ebetso ea ts'ebetso ea ts'ehetso ea bophelo, mme tlhahlobo ea bona e lekaneng e hlokahala ho khetha mokhoa o nepahetseng le maqheka a kalafo bakeng sa mokuli ka mong.

Ho ithuta li-microcirculation, mekhoa ea radionuclide (scintigraphy), capillaroscopy ea video, intravital microscopy le / ntle le ts'ebeliso ea enke ea fluorescent, laser Doppler flowmetry, polarographic transcutaneous oximetry e sebelisoa.

Haufinyane tjena, mokhoa oa ho kopanya tomographic angiography, o kopanyang theknoloji ea ho lekola khomphutha ea X-ray le angiography le tsamaiso e kenelletseng ea dae e arohaneng, e thusang ho bona methapo ea mali le phallo ea mali kahare ho bona, ke eona mokhoa o ka sehloohong oa ho hlahloba ho tsoella ha lesapo la atherosselotic.

Leha ho le joalo, ho bolela esale pele le ho phekola lefu la tsoekere la maemo a ka tlase, tekanyo e tobileng ea khatello ea oksijene khatello (khatello) (transcutaneous khatello ea oksijene - tcpO2) ke boemo ba khauta ba ho hlahloba oxygen oxygenation (Gamzina A.E. et al., 2010).

Motheo oa mokhoa ona ke boikemisetso bo bongata ba tekanyo ea oksijene ea letlalo ka tsela e sa hlaseleng e sebelisang elektrone e kentsoeng holim 'a eona.

Tekanyo ea tcpO2 e ipapisitse le mookotaba oa ho bona oksijene ka har'a lintho tsa tlhaho mme e lumella motho ho ahlola ts'ebetso ea phallo ea mali a letlalo le ho phethahala ha oksijene liseleng.

Bokhoni ba ho khutlisetsa metabolism ea tiske ho "methapo ea methapo" ea methapo e tlase ka kotlolloho ho latela tekanyo ea ts'enyo ea microvasculature, e ka khetholloang ke data ea transcutaneous ooundetry.

Ho latela boleng ba tcpO2, likhato tse latelang tsa tšitiso ea microcirculatory le metabolism ea tishu lia khetholoha:

• I (tekanyo e fokotsitsoeng ea metabolism) - tcpO2> 30 mm RT. Art.
• II (subcompensated tishu metabolism) - tcpO2 = 20-30 mm Hg. Art.
• ІІІ (metabolism e entsoeng ka tiske) - tcpO2 40 mm Hg. Art. (Rooke T., 1998) .Lits'oaetso tsa ho ts'oaroa hape ha metabolism ea tishu le oxygenation maemong a microcirculatory ka kotloloho li amana ka kotloloho le sekhahla sa tšenyo ea bethe ea methapo. Botebo ba mathata a microcirculatory le ho hanyetsoa ha metabolism ea mesifa ho ischemia ho tseba ho sebetsa ha litho tsa litho tsa maoto .. Ramatiki ea lithethefatsi e amang hantle mmuso boemo ba rheology e potlakileng le ho netefatsa hore metsoako e nyane ea Ukraine, e hlokang ho batloa ha lithethefatsi tse ncha kapa ho ithutetsoa ha thepa e seng teng ea metabolism. ke meldonium - analogue ea sebopeho sa γ-butyrobetaine ea pele ea carnitine. Carnitine e sebetsa e le moqapi oa li-acid tse qalileng tse sebetsang (li-FA) ka har'a membrane ho mitochondria, moo li-β-oxidation tsa tsona li hlahang (Titov V.N., 1997, Kalvinsh I.Ya., 2001, Soloshenko O., 2010). Meldonium, e sebetsa e le sebapali sa tlholisano ea enzyme γ-butyrobetaine hydroxylase, e fokotsa tekanyo ea biosynthesis ea carnitine e tsoang γ-butyrobetaine.Ka nako e ts'oanang, boemo ba carnitine ho cytosol bo fokotseha, FA e nyane e kena mitochondria, e lebisang ho fokotseha ha oxidation ea FA le phetoho ea metabolism ts'ebelisong e ngata ea oksijene ka ho ntšoa ha matla ho lik'habohaedreite. Ka nako ea oxidation ea tsoekere, ha e bapisoa le β-oxidation ea FAs, kotulo e lekantsoeng ea ATP e hlahisoang ka molek'hule e le 'ngoe ea oksijene e jeoang e 12-13% ho feta. Ka lebaka la sena, ts'ebetso e bolokang oksijene ea meldonium e ea phethahala. Mechanisms ea ts'ebetso ea trimethylhydrazinium propionate (meldonium) Ho bokelloa ha yr-butyrobetaine ho eketsa bioavailability ea NO - endothelial vasodilation factor, e tlatsetsang ho thathameng ha maemo a sebetsang a endothelium le, ka ho loketseng, tumellano ea methapo ea kutlo. Ya., 2001, Baumane L. et al., 2002). Mokhoa oa ho eketsa maemo a NO ha o sebelisoa ke meldonium o amahanngoa le ho hlohlelletsa hoa biosynthesis le ho fokotseha ha inactivation ea eona ka li-radicals tsa mahala. Meldonium e boetse e eketsa ts'ebetso ea li-enzyme tsa bohlokoa ka ho fetisisa mokokotlong oa aerobic glucose oxidation - hexokinase le pyruvate dehydrogenase, mme e thibela acidosis ka ho theola sebopeho sa lactate. Ts'ebetso ea metabolism ea matla, hammoho le thibelo ea ts'enyo ea mahala ea li-membochondrial membranes, e ntlafatsa kopanyo ea oxidation ka phosphorylation mme e eketsa sebopeho sa ATP. Ho ela hloko litlamorao tse 'maloa tsa meldonium (e boletsoeng anti-ischemic, antioxidant, anti-hyperglycemic), ts'ebeliso ea eona ea mofuta oa 2 ke mofuta oa kalafo ea lefu la tsoekere. e loketseng. Bokhoni ba ho fokotsa ts'ebeliso ea oksijene ho pholletsa le 'mele ("thupelo ea metabolic", kapa litlamahanyo tsa tishu), ho ntlafatsa oxidation ea tsoekere, ho thibela ho bokelloa ha li-FA-mahala tsa li-oxidized le nts'etsopele ea lactic acidosis, hammoho le ho fokotsa ho se sebetse hantle, ho bula menyetla ea ts'ebeliso ea eona e pharaletseng ts'ebetsong ea bongaka. Khalemelo ea metabolism e bohlokoa haholo bakeng sa mathata a lefu la tsoekere a kang lefu la tsoekere la methapo e ka tlase. Morero oa thuto ke ho ithuta ka matla a meldonium (Trizipin, Mikrokhim, Ukraine) ka boemo ba microvasculature ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le angiopathy ea maoto.
  

Mekhoa ea ho etsa lintho le lipatlisiso

Phuputso eo e kenyelelitse bakuli ba 30 ba nang le lefu la tsoekere la mofuta oa 2 (banna ba 15 le basali ba 15), ba ileng ba bonoa Lefapheng la Age-Endocrinology le Clinical Pharmacology, Setsi sa Naha sa "V.P. Institute of Endocrinology le Metabolism" Komissarenko "Litekanyetso tsa ho kenyelletsa: boteng ba lefu la tsoekere la mofuta oa 2, lefu la microangiopathy, lefu la pelo, khatello ea maikutlo, ho se be teng ha atherosclerosis ea libaka tse tlase, tse ileng tsa hlahlojoa motheong oa li-rheovasography (RVH) le index ea ankle-brachial. Netefatso ea nalane: nalane myocardial infarction, stroke, angina pectoris, ischemia e tebileng, bofokoli ba ulcerative libakeng tse tlase, hypersensitivity ho lithethefatsi tsa liteko, concomitant sebete pathology (hepatitis, cirrhosis) ts'ebeliso ea lithethefatsi tsa meldonium kapa li-analogues tsa eona, lithethefatsi tse nang le thepa ea vasodilation, lithethefatsi tsa nootropic. Karolelano ea lilemo tsa barupeluoa ba banna e ne e le lilemo tse 56 ± tse 2,5, mosali - 60.9 ± lilemo tse 2.1, nako ea lefu le tlasa - 10,7 ± Lilemo tse 0,8 Boemo ba hemoglobin ea glycated (HbA1c) ke 8,8 ± 0,4%. Litšobotsi tse akaretsang tsa bakuli le matšoao a ho hlahlobisisa a RVG li hlahisoa ka har'a tafole. 1 le 2. Tafole 1 Litšobotsi tse akaretsang tsa barupeluoa

Tafole ea 2 Screening RVG

Trizipine (ente) e ile ea fanoa kahare ho methapo ea 500 mg (5 ml) bakeng sa matsatsi a 10 nakong ea kalafo le lefu lena le tlase (li-antihyperglycemic agents), hammoho le mathata (α-lipoic acid, benfotiamine) tlasa maemo a maemo, joale ka sebopeho matlapa a lokolotsoeng (Trizipin® bolelele) ka tekanyetso ea 1000 mg 1 nako ka letsatsi bakeng sa matsatsi a 56 motheong oa linako tsa kantle ho kalafo. Ho ile ha etsoa tlhahlobo ea 'mele, ho kenyelletsa ho ikemisetsa ha matšoao a anthropometric, ho lateloa ke lipalo tsa BMI,' me khatello ea mali le sekhahla sa pelo li lekantsoe. Re ile ra sekaseka paramente ea biochemical (cholesterol, triglycerides, e phahameng, e tlase haholo ebile e le tlase haholo density lipoprotein cholesterol, index ea atherogenic, creatinine, bilirubin, alanine aminotransferase - AlAT, avartate aminotransferase - AsAT). Maemo a HbA1c (D-10 ™, BIO-RAD), insulin (ARHITECT ci8200, Abbot) le glucose e potlakileng ea mali le tsona li ile tsa beoa. Ho baloa ha index insulin index HOMA-IR ho etsoa ho latela mokhoa o tloaelehileng. Tlhahlobo ea tсрО2 e entsoe ho sebelisoa sesebelisoa sa TSM 400, mme RVG e etsoa ho sebelisoa mochini oa tlhahlobo oa CARDIO 02-216. SF-36 boleng ba lipotso tsa bophelo bo ile ba sebelisoa ho lekola boleng ba bophelo (Ware J.E. et al., 1993). Potso eo e kenyellelitsoe lintho tse 36 tse arotsoeng ho likala tse 8: ts'ebetso ea 'mele, liketsahalo tsa ho bapala, bohloko ba' mele, bophelo bo botle, ho sebetsa ka thata, ts'ebetso ea sechaba, boemo ba maikutlo, le bophelo ba kelello. Ts'ebetso ea sekala ka seng e fapana ho tloha ho 0-100, moo 100 e emelang boemo ba bophelo bo botle ka botlalo. Liphetho li ile tsa fetoleloa e le likala sekaleng tse 8. Boleng ba bophelo bo ne bo hakantsoe ho latela kakaretso ea data e fumaneng.Dithuto tsa laboratori, tcpO2 le ho tlatsa lipampiri tsa lipotso li ile tsa etsoa sethaleng sa tlhahlobo le kamora ho phethoa ha thupelo. Ho sebetsoa ha lipalopalo tsa sephetho ho entsoe ka lenaneo la OriginPro 8. Ha ho bapisoa lihlopha tse peli le kabo e tloaelehileng ea matšoao a fumanoeng, ho ile ha sebelisoa t-test ea Student. Bohlokoa ba bonyane ba p bo ne bo khethiloe. Phapang ea matšoao e ne e nkuoa e le bohlokoa ho p

U ka nka Mildronate ea lefu la tsoekere joang?

Mofuteng oa 2 oa lefu la tsoekere, Mildronate o thusa ho etsa tsoekere e maling. Ka hona, lingaka tse phekolang hangata li laetsoe merero ea thibelo. Liphetho tse ntle li bontšitsoe ho batho ba baholo le ho bacha.

Ka lebaka la tšebeliso ea Mildronate, lits'ebetso tsa lik'hemik'hale li potlakisitsoe, ka lebaka leo 'mele o fanoang ka mehloli ea matla. Setlhare sena se thusa ho tlatsa mesifa ea pelo le oksijene, ebe e fetisetsoa myocardium.

Tšebeliso ea lefu la tsoekere la mofuta oa 2 e na le phello e ntle likhatellong tseo lefu le li bakang:

• moriana o sebelisoa maemong a pele ho lefu la popelo,
• sesebelisoa se sebelisoa ho eketsa mamello ea 'mele oa motho ho mefuta e fapaneng ea mojaro,
• moriana o ntlafatsa haholo ho potoloha ha lisele, tse bohlokoa tsoekere e phahameng,
• e kenya letsoho kalafong ea likepe tse khutlang, tse atisang ho angoa ke lefu la tsoekere.

Ka lebaka la melemo ea likarolo tsa moriana maemong a mmele, litsebi tsa bongaka li khothaletsa ho nka Mildronate bakeng sa lefu la tsoekere.

Mokhoa oa ho sebelisa moriana

Ho khothalletsoa ho sebelisa lipilisi kapa ho li fa ente hoseng. Lebaka la sena ke 'nete ea hore sesebelisoa ke moemeli oa lisosa tsa tsamaiso ea methapo. Ka hona, haeba u nka Mildronate mantsiboea, ponahalo ea ho hloka boroko e ka etsahala.

Ho thibetsoe ka thata ho sebelisa Mildronate bakeng sa kalafo ea methapo ea pelo maemong a joalo:

• khatello e phahameng ea kelello,
• pathological neoplasms,
• maloetse a mangata a potoloha ka bokong,
• ho se mamelle batho ka bomong ho likarolo tse itseng tsa meriana.

Hoa hlokahala ho nka Mildronate ka tieo ho latela litaelo tsa ngaka e eang, ho hlokomela litekanyetso.

Ho seng joalo, liphetoho tse joalo tsa 'mele li ka etsahala:

• makhopho a sefahleho letlalong,
• maloetse a mokhoeng oa ka mpeng,
• Kholo ea Quincke,
• ponahalo ea tachycardia,
• ho batho ba tsofetseng ho na le keketseho ea khatello ea mali.

Kaha sethethefatsi ha se so ka se ithutoa ka botlalo, mabapi le tahi ea basali ba baimana le nakong ea kemolo, lingaka li e beha maemong a feteletseng. Bana ha ba khothalletsoe ho nka moriana, hobane phello e ba teng 'meleng o ntseng o hola ha o netefatsoe. Mofuta oa 1 oa lefu la tsoekere, motsoako oa Mildronate ha o hlalosoe hangata haholo.

Lingaka li khothaletsa hore bakuli ba bona ba nang le bothata ba ho eketseha ha tsoekere ea mali, ba nke lithuto tsa Mildronate. Phekolo e thusa ho boloka tšebetso ea pelo le methapo ea mali. Na Mildronate ea lefu la tsoekere a ka nooa ntle le lengolo la ngaka? Ha ho na moo u lokelang ho inahanela. Mildronate e lokela ho nkoa feela ka khothaletso ea ngaka e eang.

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Mildronate - litaelo tsa tšebeliso, theko, litekolo le li-analogues

Mildronate ke lithethefatsi tse sebelisetsoang ho eketsa tekanyo ea metabolic le ho ntlafatsa phepelo ea matla ea lisele. Moriana ona o sebelisetsoa mafu a 'maloa le maemo a methapo ea methapo. Sebelisa lithethefatsi feela khotellong ea ngaka, u latela litaelo ka hloko.

Moriana ona ka har'a sehlopha sa machaba oa ATX o na le khoutu ea C01EV.

Mildronate ke lithethefatsi tse sebelisetsoang ho eketsa tekanyo ea metabolic le ho ntlafatsa phepelo ea matla ea lisele.

Ntho ea mantlha e sebetsang ea Mildronate e emeloa ke meldonium dihydrate. Sebopeho sa li-excipients se itšetlehile haholo ka mofuta oa tokollo. Ha ho etsoa tharollo, ho sebelisoa metsi a lokisitsoeng. Lithako tse thusang tsa Mildronate, tse fumanehang ka har'a li-capsules, li kenyeletsa titanium dioxide, starch, gelatin, jj.

Ho hlahisoa ha Mildronate ka foromo ea letlapa ha ho tsoelepele.

Ho lokolloa ha Mildronate ho ka tsela ea li-capsules. Li na le khetla e bosootho bo loileng ea 'mala o mosoeu. Ho na le phofo e tšoeu kahare ho sekoaelo se seng le se seng. Phofo ena e qhibiliha haholo ka metsing.

Li-capsule tsa Mildronate lia fumaneha ka tekanyetso ea 250 mg le 500 mg. Li-capsule li na le lithako tsa 10 likhomphutha.

Litafole tse nang le Mildronate li na le mekotla ea likarete, moo ho nang le thuto e nang le tlhaiso-leseling ka lithethefatsi.

Tharollo ea ente e fumaneha ka li-ampoules tse hlakileng tsa khalase ea 1 ml le 5 ml. Ha e na mebala. Li-ente tsa Mildronate li fanoa kahare le kahare. Tharollo ea lithethefatsi e kenelletsoe ka mela ea polasetiki le mabokoseng a karete.

Sirapo e fumaneha ka libotlolong tsa khalase tse lefifi tsa 100 mg le 250 mg. Botlolo e 'ngoe le e' ngoe e tletse ka lebokoseng la karete.

Mokhoa oa ketso

Ketso ea pharmacological ea Mildronate e ipapisitse le taba ea hore ntho e sebetsang ea moriana ona ke analogue ea maiketsetso ea "gamma-butyrobetaine" e teng seleng ka 'ngoe.
Ho hlahisoa ha moriana ho ka khutlisa botsitso bo nepahetseng lipakeng tsa litlhoko tsa lisele ho oksijene le phepelo ea ntho ena. E thusa ho tlosa lintho tse chefo 'meleng oa mokuli.

Ntle le moo, ntho e sebetsang ea Mildronate eu lumella ho thibela tšenyo ea lisele. E boetse e na le phello e bitsoang antioxidant, e eketsang matla a mmele le e fokotsang palo ea litlhaselo tsa angina. Boteng ba libaka tsa necrotic lesion, ts'ebeliso e na le lebaka la ho fokotsa ts'oaetso ea foci le ho fokotsa nako ea ho hlaphoheloa.

Bophelo Ho qhekella. Mofuthu ke eng? (03/27/2016)

Liphetho tsa teko ea bongaka ea Mildronate®

PBC: Hobane, 'me ke mang ea hlokang Mildronate-Meldonium?

Seokobatsi ke eng?

Ts'ebeliso ea Mildronate e na le mabaka a mangata a mafu. Ho enta ha moriana ho sebelisetsoa hemophthalmia e tsoelang pele. Motsoako ona o tloaetse ho fuoa li-hemorrhages tsa retinal, ho sa tsotelehe etiology ea lefu lena.

Ntle le moo, ho na le phello ea kalafo ha u nka Mildronate ka thrombosis ea mothapo o bohareng le makala a eona a leng ka har'a retina. Matla a sebetsang a bonoa kamora nako ea ho hlahisoa ha Mildronate ho lefu la tsoekere le lefu la tsoekere.

Moriana ona o thusa ho felisa hypoxia ea pelo le ho fokotsa likotsi tsa infaration ea mantlha le ea sekondari. Ho khethoa ha Mildronate ho na le lebaka le nepahetseng la ho hloleha ha pelo le pelo le pelo.

Matšoao a ts'ebeliso ea moriana ona ke likotsi le methapo ea pelo. Mildronate o boetse o na le lebaka le nepahetseng kalafong ea matšoao a bang teng ha motho a khaotsa ho tsuba. Ho sebelisoa moriana bakeng sa lefu la mokhathala o sa foleng.

U ka e nka joang?

Ka lebaka la phello e thabisang e ka bang teng, moriana o lokela ho nooa hoseng. Bakeng sa mathata a tsamaiso ea methapo ea pelo, tšebeliso ea Mildronate e bontšoa ka tekanyo ea 0,5 ho isa ho 1 g ka letsatsi.

Maemong a kotsi ea "cerebrovascular", moriana o fanoa ka tekanyetso ea 0,5 ho isa ho 1 g letsatsi le letsatsi. Nako ea kalafo e qala libeke tse 4 ho isa ho tse 6. Lithuto tse phetoang li tšoaroa habeli ka selemo. Ka mokhoa o sa foleng oa botahoa, ho kenngoa ha Mildronate thupelong ea bongaka ho bontšoa ka tekanyetso ea 0,5 g letsatsi le letsatsi. Pheko e etsoa bonyane libeke tse peli.

Litlamorao

Litla-morao ha u nka Mildronate ha li fumanehe. Ho kulisa ho ka hlaha. Ho batho ba nang le hypersensitivity ho likarolo tsa moriana, angioedema e ka etsahala. Litlamorao tse ling tsa kalafo ea lithethefatsi e ka ba dyspepsia, khatello ea mali e holofetseng le tachycardia. Eosinophilia ha e hlahe hangata.

Batho ba nang le hypersensitive likarolong tsa moriana ba ka ba le mathata a ho kula.

Ho sebelisana le lithethefatsi tse ling

Ts'ebeliso ea Mildronate ha e thibetsoe hammoho le lithethefatsi tse sebelisetsoang ho fokolisa mali le ho fokotsa kotsi ea likhahla tsa mali. Li-bronchodilators le diuretics li ka sebelisoa kalafo ea Mildronate. Tlhokomelo e khethehileng e lokela ho nkuoa ha u ntse u sebelisa Mildronate le Nitroglycerin. Ntle le moo, sesebelisoa sena se ntlafatsa ts'ebetso ea pelo glycosides.

Lithethefatsi tse nang le litlamorao tse ts'oanang li kenyeletsa:

Sethethefatsi Melfor ke analogue ea Mildonate.

Lokolla liforomo le sebopeho

Ntho ea mantlha e sebetsang ea Mildronate e emeloa ke meldonium dihydrate. Sebopeho sa li-excipients se itšetlehile haholo ka mofuta oa tokollo. Ha ho etsoa tharollo, ho sebelisoa metsi a lokisitsoeng. Lithako tse thusang tsa Mildronate, tse fumanehang ka har'a li-capsules, li kenyeletsa titanium dioxide, starch, gelatin, jj.

Ho hlahisoa ha Mildronate ka foromo ea letlapa ha ho tsoelepele.

Ho lokolloa ha Mildronate ho ka tsela ea li-capsules. Li na le khetla e bosootho bo loileng ea 'mala o mosoeu. Ho na le phofo e tšoeu kahare ho sekoaelo se seng le se seng. Phofo ena e qhibiliha haholo ka metsing. Li-capsule tsa Mildronate lia fumaneha ka tekanyetso ea 250 mg le 500 mg. Li-capsule li na le lithako tsa 10 likhomphutha. Litafole tse nang le Mildronate li na le mekotla ea likarete, moo ho nang le thuto e nang le tlhaiso-leseling ka lithethefatsi.

Tharollo ea ente e fumaneha ka li-ampoules tse hlakileng tsa khalase ea 1 ml le 5 ml. Ha e na mebala. Li-ente tsa Mildronate li fanoa kahare le kahare. Tharollo ea lithethefatsi e kenelletsoe ka mela ea polasetiki le mabokoseng a karete.

Sirapo e fumaneha ka libotlolong tsa khalase tse lefifi tsa 100 mg le 250 mg.Botlolo e 'ngoe le e' ngoe e tletse ka lebokoseng la karete.