NovoMix® 30 FlexPen® Insulin aspart mekhahlelo e 'meli

Sesebelisoa se sebetsang: 1 ml ea ho emisoa bakeng sa ente e na le 100 IU / ml ea insulin aspart (rDNA) (30% e ka lerootho ea "insulin" le "" "" insulin "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "insulin" "insulin" "" "" "" "" "" "" "" "insulin" "insulin" "" "" "" "" insulin "" "" "" ""

Pene e le 'ngoe ea syringe e na le 3 ml, e lekanang le likoto tse 300

1 unit (OD) ke 6 nmol kapa 0,035 mg ea desal desulin e nang le insulin,

Ba hlahisang: glycerin, phenol, metacresol, chloride ea zinc, sodium chloride, sodium phosphate, dihydrate, protamine sulfate, sodium hydroxide, dilamin hydrochloric acid, metsi bakeng sa ente.

Melemo ea pharmacological

NovoMix ® 30 FlexPen ® ke ho emisoa ka mekhahlelo e 'meli ea soluble insulin aspart (an-insulin analog analog) e khutšoanyane le "" "" insulin "" insulin ". Ho emisoa ho na le "insulin" aspart ea ketso e khuts'oane le nako ea ts'ebetso e lekanang le 30/70. Ka ho kenyelletsa tekanyetso e tšoanang ea molar, insulin e sebetsa hantle ho insulin.

Phello e fokotsang tsoekere ea insulin ke ho khothaletsa phepelo ea tsoekere ka linama ka mor'a ho tlama insulin ho lisele tsa mesifa le mafura, hammoho le thibelo ea ho lokolloa ha tsoekere maling.

NovoMix ® 30 FlexPen ® e qala ho nka metsotso e 10-20 kamora ho tsamaisoa ha moriana. Phello e phahameng e hlaha lihora tse 1-4 kamora tsamaiso. Nako ea ketso e nka lihora tse 24.

Thutong ea bongaka e nkileng likhoeli tse 3 le ho bapisa tsamaiso ea NovoMix ®30 FlexPen ® le biphasic insulin ea motho pele ho lijo tsa hoseng le lijo tsa mantsiboea ho bakuli ba nang le lefu la tsoekere la mofuta oa II, ho ile ha bontšoa hore ka ho hlahisoa ha tsoekere ea NovoMix ® 30 FlexPen ® glucose kamora ho ja ka bobeli (lijo tsa hoseng le lijo tsa mantsiboea), e ne e le tlase haholo ha e bapisoa le tsamaiso ea biphasic insulin ea motho.

Ha ho etsoa tlhahlobo ea meta, e neng e kenyelletsa liteko tsa tleliniki tse 9 ho bakuli ba nang le lefu la tsoekere la mofuta oa II, ho ile ha hlokomeloa hore, ha ho bapisoa le insulin 30 ea batho ba bangata, tšebeliso ea NovoMix ®30 pele ho lijo tsa hoseng le lijo tsa mantsiboea e lebisa taolong ea glucose e ntle haholo ea mali (ho latela keketseho e tloaelehileng ea tsoekere ea mali ka mor'a lijo tsa hoseng, lijo tsa mots'eare le lijo tsa mantsiboea.

Leha taba ea hore glucose e potlakileng e ne e phahame ho bakuli ba fumanang kalafo ea NovoMix ®30, boemo ba hemoglobin ea glycosylated, ke sesupo sa taolo e akaretsang ea glycemic, e ne e tšoana.

Phuputsong ea bongaka, bakuli ba nang le lefu la tsoekere la mofuta oa II (batho ba 341), ba neng ba arotsoe ka lihlopha ho latela molao-motheo o hlophisitsoeng, ba fumana feela NovoMix ® 30 kapa NovoMix ® 30 hammoho le metformin kapa metformin hammoho le sulfonylureas. Kamora 'libeke tse 16 tsa kalafo, khatello ea HbA 1c ho bakuli ba fumanang NovoMix ® 30 le metformin kapa metformin le sulfonylurea le eona e ile ea tšoana. Thutong ena, ho 57% ea bakuli, khatello ea HbA 1c e ne e phahame ho feta 9%. Ho bakuli bana, ha ba phekola NovoMix ® 30 le metformin, ho fokotseha ha boemo ba HbA 1c ho ne ho le bohlokoa ho feta ka ho kopanngoa ha metformin le sulfonylurea.

Phuputsong ea bakuli ba lefu la tsoekere la mofuta oa II, moo taolo ea glycemic e sebelisang lithethefatsi tsa molomo feela e sa sebetseng, ba ile ba alafshoa ka tsamaiso ea habeli ea letsatsi le letsatsi ea NovoMix 30 (bakuli ba 117) kapa tsamaiso ea letsatsi le letsatsi ea insulin glargine (bakuli ba 116). Kamora libeke tse 28 tsa kalafo, NovoMix â 30 e tsamaisoa le khetho ea litekanyetso, boemo ba HbA 1C bo fokotsehile ka 2.8% (boleng bo bohareng ba HbA 1C ha bo kenyelelitsoe thutong = 9,7%). Nakong ea kalafo ka NovoMix â 30, 66% ea bakuli e fihlile maemong a HbA 1C ka tlase ho 7%, mme 42% e fihlile ho bakuli ba ka tlase ho 6.5%, ha khatello ea glucose e potlakileng e fokotsehile ka 7 mmol / L (ho tloha 14,0 mmol / l pele ho kalafo ho fihlela ho 7.1 mmol / l).

Ha ho etsoa tlhahlobo ea meta ho bakuli ba nang le lefu la tsoekere la mofuta oa II, ho ile ha hlokomeloa hore ka NovoMix® 30 menyetla ea ho ba le hypoglycemia bosiu le hypoglycemia e fokotsehile ha e bapisoa le biphasic insulin ea motho ka nako e ts'oanang. e phahameng ho bakuli ba fumanang NovoMix ® 30.

Bana le bacha. Phuputso e entsoeng ea libeke tse 16 e entsoeng ho bakuli ba 167 ba lilemo tse 10-18 e bapisitse katleho ea ho boloka taolo ea postprandial glycemic ka ho tsamaisa NovoMix 30 ka lijo tse sebelisang insulin ea motho / biphasic human insulin 30 le lijo tse nang le insulin NPH pele ho robala. Nako eohle ea ho ithuta ka lihlopha tsena ka bobeli, khatello ea HbA 1C e ile ea lula e le maemong a kenyellelitsoeng lithutong, ho se na phapang lipakeng tsa hypoglycemia lipakeng tsa NovoMix 30 le biphasic insulin ea motho.

Phuputsong e nang le likarolo tse peli tse sa boneng (libeke tse 12 bakeng sa thupelo e 'ngoe le e' ngoe) e entsoeng ho sehlopha se fokolang sa bana (batho ba 54) Nakong ea lilemo tse 6-12, keketseho ea palo ea liketsahalo tsa hypoglycemia le khatello ea tsoekere e ne e fokola haholo ka lipalo ha li tšoaroa ka NovoMix â 30 ha ho bapisoa le insulin ea insulin ea motho ea bophasic 30. Boemo ba HbA 1C qetellong ea nako ea kalafo bo ne bo le tlase haholo sehlopheng se amohelang insulin ea motho ea 30 ho feta sehlopheng se amohelang NovoMix â 30.

Ba tsofetseng. Pharmacodynamics ea NovoMix â 30 ha e so ithutoe ho bakuli ba tsofetseng. Leha ho le joalo, ho ile ha etsoa phuputso e sa sebetseng ea mahlo a mabeli a sa boneng mahlo e bapisang pharmacokinetics le pharmacodynamics ea insulin aspart le insulin ea insulin ea batho ba 19 ba nang le mofuta oa II lefu la tsoekere ba lilemo li 65-83 (ho bolela lilemo tse 70). Phapang e lekanang ho li-pharmacodynamics (GIR max, AUC GIR, 0-120 min) kamora ho tsamaisoa ha insulin kapa insulin ea motho ho bakuli bana e ne e tšoana le ho batho ba phetseng hantle kapa bakuli ba nang le lefu la tsoekere.

Ho insulin aspart, amino acid proline e maemong a 28 mokokotlong oa B oa molek'hule ea "insulin" e nkeloa sebaka ke acidart, e fokotsa sebopeho sa hexamers, joalo ka ha ho boletsoe litokisong tsa insulin tsa batho. Karolong e qhibilihang ea NovoMix 30, karolo ea insulin aspart ke 30% ea insulin eohle, e kenngoa maling ho tsoa linthong tse ka tlasana tse potlakileng ho feta insulin ea "insulin" ea "insulin" ea motho. 70% e setseng e ntse e le ka sebopeho sa kristale ea protamine-insulin aspart, e sa nkeloeng nako e telele haholo e tšoanang le insulin ea motho. Kakaretso e phahameng ea "insulin" serum ea mali ka mor'a ho kenngoa ha NovoMix 30 e phahame ka 50%, 'me nako ea ho e fihlela ke halofo ea biphasic insulin ea motho ea 30 Ho baithaopi ba phetseng hantle, kamora taolo e tlase ea NovoMix 30 ka tekanyo ea 0,20 U / kg ea boima ba' mele. serum insulin aspart e fumanoe kamora metsotso e 60, e ne e le 140 ± 32 pmol / L. Bophelo ba halofo ea NovoMix ® 30 (t½), e bonts'a tekanyo ea ho amoheloa ha karolo ea protamine, e ne e ka ba lihora tse 8 8-9. Maemo a insulin ea insulin a khutletse molemong oa lihora tse 15-18 kamora taolo ea subcutaneous. Ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, khatello e phahameng e fihlelletsoe metsotso e 95 ka mor'a ts'ebetso mme ea lula ka holim'a bonyane lihora tse 14.

Ba tsofetseng. Pharmacokinetics ea NovoMix â 30 ha e so ithutoe ho bakuli ba tsofetseng. Leha ho le joalo, phapang e lekanang le ea boleng ba pharmacokinetics kamora ts'ebetso ea insulin aspart kapa insulin ea motho ho bakuli ba nang le mofuta oa II lefu la tsoekere (lilemo tse 65-83, lilemo tse pakeng tsa 70) li ne li tšoana hantle le ho batho ba phetseng hantle kapa bakuli ba nang le lefu la tsoekere. Ho bakuli ba tsofetseng le ba senele, tekanyo ea ho kenngoa e fokotseha, joalo ka bopaki ba nako e teletsana ea ho fihlella palo e phahameng ea insulin maling a max (82 min ka sebaka se kopaneng sa 60-120 min). Boleng ba C max bo ne bo tšoana hantle le ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba banyenyane hape le tlase hanyane ho bakuli ba nang le lefu la tsoekere la mofuta oa 1.

Ho senyeha ha renal le hepatic.

Pharmacokinetics ea NovoMix ® 30 ha e so ithutoe ho bakuli ba nang le bothata ba ho ruruha ba mokokotlo kapa ba hepatic.

Bana le bacha. Li-pharmacokinetics tsa NovoMix â 30 ha lia ka tsa ithutoa ho bana le lilemong tsa bocha. Leha ho le joalo, ho bana (ba lilemo li 6-12) le ba lilemong tsa bocha (ba lilemo li 13 ho isa ho tse 17) ba nang le lefu la tsoekere la 1, ho ile ha ithutoa li-pharmacokinetics le pharmacodynamics tsa soluble aspart insulin. E ne e kenngoa ka potlako ho bakuli ba lihlopha tsena ka bobeli, ha litekanyetso tsa t max li ne li tšoana hantle le ho batho ba baholo. Khabareng, boleng ba C max ka lihlopha tse fapaneng tsa lilemo li fapane haholo, e leng ho bonts'a bohlokoa ba khetho ea motho ka mong ea litekanyetso tsa "insulin".

Tlhahiso-leseling ea polokeho.

Lintlha tse fumanehang motheong oa lithuto tsa setso mabapi le polokeho ea meriana, tšebeliso ea litekanyetso tsa lithethefatsi, genotoxicity le chefo ea ho ikatisa ha li hlahise kotsi e itseng ho batho.

Litekong tsa in vitro, ho kenyelletsa ho tlama li-insulin le li-receptor tsa IGF-1 le litlamorao ho kholo ea sele, insulin aspart e ne e tšoana le insulin ea motho. Boithuto bo boetse bo bontšitse hore ho ikarola ho tlama ho li-insulin receptors tsa insulin aspart ho lekana le insulin ea motho.

Foromo ea litekanyetso

Ho emisoa bakeng sa tsamaiso e potolohileng, 100 PIECES / ml

1 ml ea ho emisoa e na le

ntho e sebetsang - insulin aspart 100 U (3.5 mg) (30% e qhibilihang ka insulin le "insulin" e nang le insulin e lla ka protamine),

baamohelang: zinc, glycerol, phenol, metacresol, sodium hydrogen phosphate dihydrate, sodium chloride, protamine sulfate, hydrochloric acid, sodium hydroxide, metsi a ente.

Ho emisoa ho tšoeu ho tšoeu, nakong ea polokelo, e kengoe ka har'a 'mala o phatsimang, o se nang' mala kapa o batlang o se na 'mala le o mosoeu o mosoeu. Ha o kopanya se kahare ho pene, ho lokela ho emisoa ka mokhoa o khahlisang.

Tekanyetso le tsamaiso

NovoMix® 30 FlexPen® e etselitsoe feela bakeng sa tsamaiso e potolohileng. NovoMix® 30 FlexPen® ha ea lokela ho tsamaisoa ka matla, kaha sena se ka lebisa ho hypoglycemia e matla. Tsamaiso ea methapo ea methapo ea NovoMix® 30 FlexPen® le eona e lokela ho qojoa. Se ke oa sebelisa NovoMix® 30 FlexPen® bakeng sa infcutaneous insulin infusion (PPII) lipompong tsa insulin.

Tekanyetso ea lithethefatsi e khethoa ke ngaka ka bonngoe boemong bo bong le bo bong, ho ipapisitse le boemo ba tsoekere maling.

Bakuli ba nang le lefu la tsoekere la mofuta oa 2, NovoMix® 30 FlexPen® ba ka fuoa meriana e le monotherapy hape ba kopantsoe le litlhare tsa hypoglycemic maemong ao boemo ba glucose ba mali bo sa laoloeng ka ho lekaneng ke lithethefatsi tsa molomo tsa hypoglycemic feela.

Bakeng sa bakuli ba nang le lefu la tsoekere la mofuta oa 2, lethal dose le khothalletsoang la NovoMix® 30 FlexPen® ke likarolo tse 6 hoseng le likarolo tse 6 ka phirimana (ka lijo tsa hoseng le tsa mantsiboea, ka ho latellana). E boetse e lumelloa ho nka likarolo tse 12 tsa NovoMix® 30 FlexPen® hang ka letsatsi mantsiboea. Maemong a morao-rao, leha ho le joalo, kamora ho nka likarolo tsa 30 tsa moriana, ho kgothaletsoa ho fetola ho nka NovoMix® 30 FlexPen® habeli ka letsatsi, e arola lethal dose ka likarolo tse lekanang (ka lijo tsa hoseng le tsa mantsiboea, ka ho latellana). Phetoho e bolokehileng ea ho nka NovoMix® 30 FlexPen® makhetlo a mararo ka letsatsi e ka etsahala ka ho arola tekanyetso ea hoseng ka likarolo tse peli tse lekanang le ho nka likarolo tsena tse peli hoseng le thapama.

Bakeng sa bakuli ba hanyetsang insulin (mohlala, ka lebaka la botenya), tlhoko ea insulin ea letsatsi le letsatsi e kanna ea eketsoa, ​​'me ho bakuli ba nang le masala a secretion a insulin, a ka fokotsoa.

Ho khothaletsoa tafole e latelang bakeng sa tokiso ea lethal dose.

Glucose ea mali pele u e-ja

Phetohomethapo NovoMix® 30

NovoMix® 30 FlexPen® e lokela ho tsamaisoa hang-hang pele ho lijo. Ha ho hlokahala, NovoMix® 30 FlexPen® e ka tsamaisoa haufinyane kamora ho qala lijo.

Mocheso oa "insulin" o sebelisoang o lokela ho ba ka mocheso oa kamore.

NovoMix® 30 FlexPen ® e lokela ho tsamaisoa ka mokhoa o potelletseng ka thipa kapa ka mpeng ea mpa ea mpa. Haeba ho hlokahala, sethethefatsi se ka tšeloa mahetleng kapa marikeng.

Hoa hlokahala ho fetola sebaka sa ente kahare ho sebaka sa anatomical e le ho thibela nts'etsopele ea lipodystrophy.

Joalo ka litokisetso tse ling tsa insulin, nako ea ts'ebetso ea NovoMix® 30 FlexPen® e ipapisitse le tekanyetso, sebaka sa tsamaiso, matla a phallo ea mali, mocheso le boemo ba tšebetso ea 'mele. Ho itšetleha ka ho kenngoa ha NovoMix® 30 FlexPen® sebakeng sa ente ha ho e-so ithutoe.

Phetoho ea mori le eona e ka hlokahala haeba mokuli a e-na le mafu a a amanang le a liphio, sebete, ho senyeha hoa sesole sa adrenal, gland ea pituitary kapa tšoelesa ea qoqotho.

Tlhokahalo ea tokiso ea tekanyetso e ka hlaha le ha o fetola ts'ebetso ea 'mele kapa lijo tse tloaelehileng tsa mokuli. Ho ka hlokahala phetoho ea tekanyetso ha u fetisetsa mokuli ho tsoa mofuteng o mong oa insulin ho ea ho e 'ngoe.

Batho ba baholo le ba senile

NovoMix® 30 FlexPen® e ka sebelisoa ho bakuli ba tsofetseng, leha ho le joalo, boiphihlelo ka ts'ebeliso ea eona hammoho le lithethefatsi tsa molomo tsa hypoglycemic ho bakuli ba lilemo li ka tlase ho 75 li na le moeli.

Bakeng sa bakuli ba nang le bothata ba ho renal kapa hepatic, tlhoko ea insulin e ka fokotsoa.

Bakeng sa bakuli ba tsofetseng, ho hlokahala hore ho hlahlojoe maemo a tsoekere ea mali le ho fetola tekanyetso ea "insulin" ea insulin e thehiloeng ho data ka bomong.

Bana le bacha

NovoMix® 30 FlexPen® e ka sebelisoa ho phekola bana le bacha lilemong tse fetang tse 10 maemong ao ho sebelisoang insulin e tsoakiloeng pele. Lintlha tsa kliniki tse fokolang li fumaneha ho bana ba lilemo tse 6 ho isa ho 9.

Litlhokomelo tsa ts'ebeliso:

NovoMix® 30 FlexPen ® le linale ke tsa ts'ebeliso ea hau feela. Se ke oa tlatsa karete ea pentšele ea syringe.

NovoMix® 30 FlexPen® e ke ke ea sebelisoa haeba ka mor'a ho e kopanya e se soeufale ebile e le maru.

Hoa hlokahala ho kopanya ho emisoa hoa NovoMix® 30 FlexPen® pele o sebelisoa. Se ke oa sebelisa NovoMix® 30 FlexPen® haeba e se e le leqhoa. Lahla nale ka mor'a ente e 'ngoe le e' ngoe.

Litlamorao

Boitšoaro bo bobe bo bonoang ho bakuli ba sebelisang NovoMix ® 30 FlexPen ® e itšetlehile haholo ka litekanyetso mme e bakwa ke phello ea litheko tsa insulin.

Tse latelang ke litekanyetso tsa khafetsa tsa karabelo e mpe e bonts'itsoeng nakong ea liteko tsa tleliniki, tse neng li nkuoa li amana le tšebeliso ea NovoMix® 30 FlexPen ®. Khafetsa e ne e ikemiselitsoe ka tsela e latelang: khafetsa (≥ 1/10), hangata (≥ 1/100 ho

Fomati e lokollang

Ho emisoa bakeng sa s / c tsamaiso ea 'mala o mosoeu, o homogenible (ntle le maqhubu, makhasi a ka hlaha sampole), ha a arohana, a fafatsa,' me a theha sethala se sesoeu ebile a le mebala e mengata kapa a batla a se na 'mala, ka tšusumetso e bonolo ea setaele.

Bahlomphehi: glycerol - 16 mg, phenol - 1.5 mg, metacresol - 1,72 mg, chloride ea zinc - 19.6 μg, sodium chloride - 0,877 mg, sodium hydrogen phosphate dihydrate - 1,25 mg, protamine sulfate

0,33 mg ea sodium hydroxide

2.2 mg, hydrochloric acid

1,7 mg, metsi d / i - ho fihlela 1 ml.

3 ml (300 PIECES) - li-cartridge (5) - maleiri (1) - lipakete tsa karete.

Ketso ea pharmacological

Ke ho emisoa ka mekhahlelo e 'meli ho kenyelletsoang motsoako oa li-insulin analog: insuble insulin aspart (30% e nkang insulin analog) le likristale tsa insulin tsa "antiart protamine" tse 70%.

Ho fokotseha ha tsoekere ea mali ho etsahala ka lebaka la keketseho ea phallo ea eona ea bohlokoa ka mor'a ho kenngoa ha insulin aspart biphasic ka li-insulin receptors tsa mesifa le adipose tiske le thibelo e ts'oanang ea tlhahiso ea tsoekere ke sebete.

Litla-morao

Karolong ea boits'ireletso ba mmele: khafetsa - urticaria, lekhopho la letlalo, lekhopho la letlalo, hangata - litla-morao tsa anaphylactic.

Ho tloha lehlakoreng la metabolism le phepo e nepahetseng: khafetsa - hypoglycemia.

Ho tsoa ts'ebetsong ea methapo: ka seoelo - peripheral neuropathy (bohloko ba methapo ea kutlo).

Ho tloha lehlakoreng la setho sa pono: khafetsa - liphoso tse ntlafatsang, lefu la tsoekere.

Ho tsoa letlalong le linama tse ka tlasana: hangata - lipodystrophy.

Liphetoho tse akaretsang: khafetsa - edema.

Bokhachane le pelehi

Phihlelo ea kliniki ka boimana e na le moeli.

Nakong ea ho qala ho ka etsahala ha moimana le nakong eohle ea bophelo ba hae, ho hlokahala hore ho hlahlojoe ka hloko boemo ba bakuli ba nang le lefu la tsoekere le ho beha leihlo tsoekere maling. Tlhokahalo ea insulin, joalo ka molao, e fokotseha ho trimester ea pele mme butle-butle e eketseha ka li-trimesters tsa bobeli le tsa boraro tsa boimana. Nakoana kamora ho hlaha, tlhoko ea insulin kapele e khutlela boemong bo neng bo le pele ho ima.

Nakong ea ho anyesa, e ka sebelisoa ntle le lithibelo. Tsamaiso ea insulin ho 'm'a ea anyesang ha se tšokelo ho ngoana. Leha ho le joalo, ho ka hlokahala hore phetoho ea tekanyetso e be e hlokahalang.

Sebelisa ho bana

Ha e khothalletsoe bana ba ka tlase ho lilemo tse 6, joalo ka liteko tsa tliliniki ha li e-so tšoaroe.

E ka sebelisoa ho phekola bana le bacha lilemong tse fetang tse 10 maemong a ha ho khethoa tšebeliso ea insulin e tsoakiloeng pele. Lintlha tsa kliniki tse lekantsoeng li fumaneha ho bana ba lilemo li 6-9.

Litaelo tse khethehileng

Pele ho leeto le lelelele le amanang le phetoho ea libaka, mokuli o lokela ho buisana le ngaka ea hae, kaha ho fetola nako ho bolela hore mokuli o lokela ho ja le ho fana ka insulin ka nako e fapaneng.

Tekanyetso e sa lekaneng ea lithethefatsi kapa ho khaotsa ho phekoloa, haholo-holo ka lefu la tsoekere la mofuta oa 1, ho ka lebisa nts'etsopele ea hyperglycemia kapa lefu la tsoekere. E le molao, matšoao a pele a hyperglycemia a hlaha butle butle, ho feta lihora tse 'maloa kapa matsatsi. Matšoao a hyperglycemia ke maikutlo a ho nyoriloe, ho eketseha ha moroto o ntšoang, ho nyekeloa, ho hlatsa, ho otsela, ho ruruha le ho omella ha letlalo, molomo o omileng, ho felloa ke takatso ea lijo le ponahalo ea monko oa asiti moeeng o tsoang. Ntle le kalafo e nepahetseng, hyperglycemia ho bakuli ba lefu la tsoekere la mofuta oa 1 e ka lebisa ho lefu la tsoekere la ketoacidosis, boemo bo ka bolaeang.

Ho tlōla lijo kapa ho ikoetlisa ka thata ka tsela e sa reroang ho ka lebisa ho hypoglycemia. Hypoglycemia e ka boela ea hlaha haeba tekanyetso ea insulin e phahame haholo ha e bapisoa le litlhoko tsa mokuli.

Kamora ho lefa tefo ea metabolism ea carbohydrate, ka mohlala, ka kalafo e matlafatsang ea insulin, bakuli ba ka
matšoao a tloaelehileng a phetoho ea hypoglycemia, eo bakuli ba lokelang ho tsebisoa ka eona. Matšoao a tloaelehileng a temoso a ka nyamela ka nako e telele ea lefu la tsoekere.

Mafu a khahlang, haholo a tšoaetsanoang le feberu, hangata a eketsa tlhoko ea mmele ea insulin. Phetoho ea mori le eona e ka hlokahala haeba mokuli a e-na le mafu a a amanang le a liphio, sebete, ho senyeha hoa sesole sa adrenal, gland ea pituitary kapa tšoelesa ea qoqotho.

Ha u fetisetsa mokuli ho mefuta e meng ea insulin, matšoao a pele a li-hypoglycemia a ka fetoha kapa a ba tlase haholo ha a bapisoa le ba sebelisang mofuta oa insulin o fetileng.

Ho fetisetsoa ha mokuli ho mofuta o mocha oa insulin kapa tokisetso ea insulin ea moetsi e mong ho tlameha ho etsoa ka tlasa tlhokomelo e thata ea bongaka. Haeba u fetola khatello ea maikutlo, mofuta, moetsi le mofuta (insulin ea motho, analog ea insulin ea motho) ea litokisetso tsa insulin le / kapa mokhoa oa tlhahiso, ho ka hlokahala phetoho ea tekanyetso.

Litaba tsa ho ntlafala ha lefu la pelo le sa foleng li tlalehiloe kalafong ea bakuli ba nang le thiazolidinediones hammoho le litokisetso tsa insulin, haholoholo haeba bakuli ba joalo ba na le mabaka a tlisoang ke ho hola ho sa feleng ha pelo. Ntlha ena e lokela ho ananeloa ha ho fanoa ka phekolo ea ho kopanya le thiazolidinediones le litokisetso tsa insulin ho bakuli. Ka ho khethoa ha mofuta o joalo oa phekolo, ho bohlokoa ho etsa tlhahlobo ea bongaka ea bakuli ho bona matšoao le matšoao a ho se atlehe ha pelo, boima ba mmele le boteng ba edema. Haeba matšoao a ho hloleha ha pelo a mpefala ho bakuli, kalafo e nang le thiazolidinediones e tlameha ho khaotsa.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa

Bokhoni ba bakuli ba ho tsepamisa mohopolo le sekhahla sa karabelo se ka senyeha nakong ea hypoglycemia, e ka bang kotsi maemong ao bokhoni bona bo hlokahalang haholo (mohlala, ha o khanna makoloi kapa o sebetsa ka mechine le metjeko).

Bakuli ba lokela ho eletsoa ho nka mehato ea ho thibela nts'etsopele ea hypoglycemia ha u ntse u khanna. Sena se bohlokoa ka ho khetheha ho bakuli ba se nang matšoao a pele kapa a fokotsehileng a tsoelopele ea hypoglycemia kapa ba nang le liketsahalo tsa khafetsa tsa hypoglycemia. Maemong ana, ho tšoaneleha ho tšoaneleha ha ho khanna le ho etsa mosebetsi o joalo.

Ho sebelisana le lithethefatsi

Hona le lithethefatsi tse 'maloa tse amang tlhokahalo ea insulin. Hypoglycemic phello ea ka insulin ntlafatsa lithethefatsi molomo hypoglycemic, Mao inhibitors, inhibitors Ace, k'habone anhydrase inhibitors ha khetha beta-blockers, bromocriptine, sulfonamides, anabolic steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithethefatsi lithium salicylates .

Tšusumetso ea "hypoglycemic" ea "insulin" e fokotsoa ke lithibela-pelehi tsa molomo, li-glucocorticosteroids, lihomone tsa qoqotho, li-thiazide diuretics, heparin, li-antidepressants tsa troteclic, li-psychathomimetics, li-somatropin, danazole, clonidine, li-blockchain tsa calcium butle, diazoxide, morphine.

Beta-blockers li ka pata matšoao a hypoglycemia.

Octreotide / lanreotide ka bobeli li ka eketsa le ho fokotsa tlhoko ea mmele ea insulin.

Joala bo ka ntlafatsa kapa ba theola phello ea hypoglycemic ea insulin.