Lipothioxone - litaelo tsa semmuso bakeng sa tšebeliso

Lintho tse sebetsang:
Meglumina thioctate **	- 583.86 mg	- 1167.72 mg
mabapi le thioctic acid (alpha lipoic acid)	- 300 mg	- 600 mg
Baeti:
Macrogol (macrogol-300)	- 2400 mg	- 4800 mg
Sodium Sulfite Anhydrous	- 6 mg	- 12 mg
Disetetet e tsoang pele	- 6 mg	- 12 mg
Meglumine	12,5 mg ho 35 mg (ho fihlela ho pH 8.0-9.0),	25 mg ho isa ho 70 mg (ho fihlela ho pH 8.0-9.0)
Metsi bakeng sa ente	ho fihlela 12 ml	ho fihlela 24 ml

** meglumine thioctate e thehoa ka lebaka la ts'ebelisano ea thioctic acid 300 mg (600 mg) le meglumine 283.86 mg (567.72 mg)

hlakileng metsi ho tloha mosehla o mosehla ho isa ho o mosehla o mosehla.

Melemo ea pharmacological

Thioctic acid (alpha-lipoic acid) - e leng antioxidant ea endo native (e kopanyang li-radicals tsa mahala), e thehoa 'meleng ka oxidative decarboxylation ea alpha-keto acid. Ha e le coenzyme ea mitochondrial multenzyme complexes, e ameha ka oxidative decarboxylation ea pyruvic acid le alpha-keto acid. E thusa ho fokotsa khatello ea "glucose" maling le ho eketsa glycogen sebete, hammoho le ho hlola insulin. Ka mofuta oa ts'ebetso ea biochemical, e haufi le livithamini tsa B. E nka karolo taolong ea metabolism ea lipid le carbohydrate, e matlafatsa metabolism ea cholesterol, mme e ntlafatsa ts'ebetso ea sebete. E na le hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. E ntlafatsa li-neurons tsa trophic.

Mofumahali
Ka tsamaiso ea methapo, nako ea ho fihlela khatello e kholo ke 10-11 min, boholo bo phahameng ke 25-38 μg / ml, sebaka se ka tlas'a nako ea nako ea mahloriso se ka ba 5 μg h / ml. Bioavailability ke 30%.
Thioctic acid e na le "pele feta" e amang sebete. Ho thehoa ha metabolites ho etsahala ka lebaka la oxidation ea lehlakore le thipa.
Boholo ba kabo e ka ba 450 ml / kg. Thioctic acid le metabolites ea eona li hlahisoa ke liphio (80-90%). Ho felisoa ha halofo ea bophelo ke metsotso e 20-50. Tlhahiso ea plasma ka botlalo ke 10-15 ml / min.

Tekanyetso le tsamaiso

Setlhare se etselitsoe ho hlophisoa ha tharollo ea infusion kamora ho qala ho hlatsoa tharollo ea isotonic sodium chloride.
Mefuteng e matla ea lefu la tsoekere kapa lino tse nang le tahi, 300-600 mg 1 nako ka letsatsi e lokela ho fanoa e le infusion e kenang ea lerapo. Ho kenella ka hare ho mpa ho lokela ho tsamaisoa pele ho feta metsotso e 50. Sethethefatsi se khothalletsoa hore se sebelisoe nakong ea libeke tse 2 ho isa ho tse peli. Kamora moo, o ka tsoela pele ho nka acid e mashome a mararo a metso e tšeletseng kahare ka tekanyetso ea 300-600 mg ka letsatsi. Nako e fokolang ea kalafo ka matlapa ke likhoeli tse 3.

Litla-morao

Ka ts'ebetso ea methapo ea methapo, ho tsitsipana, diplopia, lintlha tse hemang ka har'a li-membrane tsa mucous, letlalo, thrombocytopathy, hemorrhagic rash (purpura), thrombophlebitis ha li khonehe haholo. Ka tsamaiso e potlakileng, ho eketseha ha khatello ea maqhubu ho khoneha (ponahalo ea maikutlo a boima hloohong), ho hema ka thata. Litlamorao tse thathamisitsoeng li itlhahela ka bobona.
Litlamorao li ka etsahala: urticaria, systemic allergic reaction (ho fihlela nts'etsopele ea anaphylactic shock).
Hypoglycemia e ka hlaha (ka lebaka la ntlafatso ea tsoekere e ntlafalitsoeng).

Sokolla foromo le sebopeho

Foromo ea litekanyetso ke mohopolo bakeng sa ho hlophisoa ha tharollo ea ho kenella: mokelikeli o hlakileng o tsoang ho botala bo botala ho isa ho 'mala o mosehla (ka paketeng ea 1 kh'outu ea polasetiki kapa sephutheloana sa polasetiki se nang le li-ampoules tse 5 tsa 12 kapa 24, le litaelo tsa ts'ebeliso ea Lipothioxone).

Sebopeho ka seng 1 ampoule:

ntho e sebetsang: thioctic (α-lipoic) acid - 300 kapa 600 mg (ka sebopeho sa meglumine thioctate - 583.86 kapa 1167.72 mg, e entsoe ka lebaka la ts'ebelisano ea thioctic acid le meglumine),
likarolo tse thusang (300/600 mg): anhydrous sodium sulfite - 6/12 mg, macrogol-300 - 2400/4800 mg, meglumine - ho fihla ho PH 8-9 (12.5-35 mg / 25-70 mg), edetate disodium - 6/12 mg, metsi bakeng sa ente - ho fihlela ho 12/24 ml.

Mofumahali

Asiti ea "Thioctic (α-lipoic)" ke "antioxidant" ea tlhaho e kopantseng li-radicals tsa mahala, sebopeho sa 'mele se etsahala nakong ea oxidative decarboxylation ea li-acid tsa α-keto. E le coenzyme ea mitochondrial multenzyme complexes, thioctic acid e kenella ho oxidative decarboxylation ea α-keto acid le pyruvic acid.

Lipothioxone e na le hepatoprotective, hypolipidemic, hypoglycemic le hypocholesterolemic effect. Ka mofuta oa litlamorao tsa biochemical tsa α-lipoic acid e haufi le livithamini tsa sehlopha sa B.

Litlamorao tse ka sehloohong tsa thioctic acid:

fokotseha ha tsoekere ea glucose e ngata,
Keketseho ea glycogen sebete,
ho hlola insulin,
ho nka karolo taolong ea khafetsa lik'habohaedreite le lipid metabolism,
tshusumetso ea metabolism ea cholesterol,
ho ntlafatsa ts'ebetso ea sebete sa hau le ho ntlafatsa trophism ea li-neurons.

Mofumahali

Palo e phahameng ea thioctic acid e nang le tsamaiso ea methapo e fihlelloa ka metsotso e 10-11, ke 0.025-0.038 mg / ml. Sebaka se ka tlas'a "khopolong" nako -

0.005 mg h / ml. Bioavailability boemong ba 30%.

Ntho e na le phello ea ho feta ho fetela ka har'a sebete. Ts'ebetso ea sebopeho sa metabolite e amahanngoa le conjugation le oxidation ea ketane ea lehlakoreng.

450 ml / kg. Excretion ea ntho le metabolites ea eona e etsahala haholo ke liphio (ho tloha ho 80 ho isa ho 90%). Ho felisoa ha halofo ea bophelo ho etsa metsotso e 20-50. Hlakollo e felletseng ea plasma e maemong a fapaneng a 10-15 ml / min.

Lipothioxone, litaelo tsa tšebeliso: mokhoa le litekanyetso

Lipothioxone e tsamaisoa ka mokhoa o kenang ka mokhoa oa infusions kamora ho kenngoa kahare ho tharollo ea isotonic sodium chloride.

Maemong a tebileng a pathology, tharollo e fanoa hanngoe ka letsatsi ka tekanyetso ea ho thellisoa ha 300-600 mg ka metsotso e 50.

Nako e khothalletsoang ea kalafo ke libeke tse 2-5. Qetellong ea nako ena, kalafo e ntse e tsoela pele le taolo ea molomo ea thioctic acid ka lethal dose le le leng bakeng sa nako ea likhoeli tse 3.

Litlamorao

Maemong a sa tloaelehang haholo, khahlano le semelo sa ho hlahisoa ha Lipothioxone, ho ba le nts'etsopele ea maloetse ka mokhoa oa ho ts'oaroa, diplopia, thrombophlebitis, hemorrhages ea letlalo letlalong le mucous membrane, hemorrhagic rash (purpura), thrombocytopathy.

Haeba tharollo e kenella ka potlako, ho ka hlaha mathata a ho hema le khatello e matla ea maqhubu (e bonahatsoa joalo ka hlooho). Hangata maikutlo ana a fosahetseng a itlhahela feela.

Urticaria, systemic allergic reaction (ho fihlela ho anaphylactic shock) e ka hlaha.

Ho ntlafatsa tšebeliso ea tsoekere ho ka baka hypoglycemia.

Litaelo tse khethehileng

Bakuli ba nang le lefu la tsoekere, haholo-holo qalong ea tšebeliso ea Lipothioxone, ba hloka ho hlahlojoa khafetsa ha tsoekere e maling. Ka linako tse ling tekanyo ea li-agents tsa hypoglycemic e hloka ho fokotsoa.

Ho khothalletsoa ho hana ho noa joala nakong ea kalafo, hobane e fokotsa phello ea pheko.

Ampoules e tsoang sephutheloaneng e lokela ho tlosoa hang-hang pele e sebelisoa, kaha Lipothioxone e na le khanya e phahameng. Nakong ea infusion, ho bohlokoa ho sireletsa tharollo ea vial hore e se ke ea pepesetsoa leseli ka ho e koahela ka foil ea aluminium kapa ka ho e kenya ka mekotleng e sa keneleng khanya.

Kamora ho hlapisoa, lipothioxone e lokela ho sebelisoa lihora tse 6, ha feela e bolokiloe sebakeng se lefifi.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

In / in (jet, drip), in / m.

Mefuteng e matla ea li-polyneuropathies - iv butle (50 mg / min), 600 mg kapa iv drip, ka tharollo ea 0,9% NaCl hang ka letsatsi (maemong a boima, ho fihla ho 1200 mg e fanoa) bakeng sa libeke tsa 2-4. Ho / kenyelletsong ho khonahala ka thuso ea moetsi oa litlolo (nako ea tsamaiso - bonyane metsotso e 12).

Ka ente ea / m sebakeng se le seng, tekanyetso ea moriana ha ea lokela ho feta 50 mg.

Kamora nako, ba fetola kalafo ea molomo bakeng sa likhoeli tse 3.

Ketso ea pharmacological

Coenzyme ea mitochondrial multenzyme complexes e amehang ho oxidative decarboxylation ea pyruvic acid le alpha-keto acid e bapala karolo ea bohlokoa ho matla a mmele. Ka mofuta oa ts'ebetso ea biochemical, thioctic (alpha-lipoic) acid e tšoana le livithamini tsa B. Ke endo native antioxidant. E kenya letsoho taolong ea metabolism ea lipid le carbohydrate, e na le phello ea lipotropic, e ama metabolism ea cholesterol, e ntlafatsa ts'ebetso ea sebete, e na le phello ea detoxifying haeba ho na le chefo ka letsoai le boima la lino tse tahang. Kameho ea metabolism ea carbohydrate e bontšoa ka ho fokotseha ha khatello ea tsoekere ea mali le keketseho ea glycogen sebeteng, hammoho le ho hlola insulin. E ntlafatsa li-neurons tsa trophic.

Lipotso, likarabo, litlhahlobo mabapi le lithethefatsi Lipothioxone

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebeletsang e le sebaka sa boipiletso ba motho ho setsebi.