Sanovasc - (Sanovasc)

Li-analogues tsa moriana oa sanovask li hlahisoa, li fetoloa ke phello 'meleng, litokisetso tse nang le ntho e le' ngoe kapa tse ling tse tšoanang tse sebetsang. Ha u khetha li-synonyms, u se ke ua nahana feela ka litšenyehelo tsa bona, empa hape le naha ea tlhahiso le botumo ba moetsi.

1. Tlhaloso ea lithethefatsi
2. Lethathamo la li-analogues le litheko
3. Litlhahlobo
4. Litaelo tsa semmuso bakeng sa tšebeliso

Tlhaloso ea lithethefatsi

Sanovask - Li-NSAID. E na le litlamorao tse khahlanong le ho ruruha, li-analgesic le antipyretic, hape e thibela ho kopanngoa ha liplatelete. Mochine oa ts'ebetso o amahanngoa le thibelo ea ts'ebetso ea COX - enzyme ea mantlha ea metabolism ea arachidonic acid, e leng moetapele oa li-prostaglandins, tse etsang karolo e kholo ho pathogeneis ea ho ruruha, bohloko le feberu. Ho fokotseha ha litaba tsa li-prostaglandins (haholo-holo E 1) bohareng ba thermoregulation ho lebisa ho fokotseha ha mocheso oa 'mele ka lebaka la ho eketsoa ha methapo ea mali letlalong le ho fufuleloa ho eketsehileng. Phello ea analgesic e bakiloe ke ketso ea bohareng le e bohareng. Fokotsa ho kopanya, ho khokhotheha ka liplatelete le thrombosis ka ho thibela ho hlophisoa ha thromboxane A 2 ka liplatelete.

Fokotsa lefu la motho le kotsi ea ho theoleloa ka bohloeki ba myocardial le angina e sa tsitsang. E atlehang ho thibelo ea mantlha ea mafu a pelo le methapo ea thibelo ea bobeli ea infarction ea myocardial. Ka tekanyetso ea letsatsi le letsatsi ea 6 g kapa ho feta, e thibela ho kopana ha prothrombin ka har'a sebete mme e eketsa nako ea prothrombin. E eketsa ts'ebetso ea plasma ea fibrinolytic mme e fokotsa mokokotlo oa lintlha tse amanang le ho ruruha ha vitamini (II, VII, IX, X). Ho eketsa mathata a hemorrhagic nakong ea ts'ebetso ea ho buoa, ho eketsa kotsi ea ho tsoa mali nakong ea kalafo ka li-anticoagulants. E hlohlelletsa excretion ea uric acid (e sitisa ho ts'oaroa ha eona ka har'a lipompo), empa e noe haholo. Blockade ea COX-1 ka mpeng ea gastric mucosa e lebisa ho thibelo ea li-prostaglandins tsa gastroprotective, tse ka lebisang ho lcrance ea membrane ea mucous le ho tsoa mali hamorao.

Fomati e lokollang

Matlapa ana a entsoe ka 'mala oa filimi ea enteric oa' mala o mosoeu kapa o batlang o le mosoeu, o chitja, biconvex, karolong ea sefapano - mookotaba oa 'mala o mosoeu kapa o batlang o le mosoeu le mokokotlo o moqotetsane.

1 tab
acetylsalicylic acid	50 mg

Bahlomphehi: lactose monohydrate - 31,5 mg, cellcrystalline cellulose - 16,3 mg, colloidal silicon diode - 1,7 mg, starch ea carboxymethyl ea sodium - 0.5 mg.

Sebopeho sa Shell: Copolymer ea methaconic acid le ethyl acrylate 1: 1 - 3.35 mg, povidone K17 - 0.56 mg, talc - 0.75 mg, macrogol 4000 - 0,34 mg.

Li-pcs tse 10. - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (9) - lipakete tsa karete.
Li-pcs tse 30 - makotikoti a polymer (1) - lipakete tsa karete.
Likhomphutha tse 60. - makotikoti a polymer (1) - lipakete tsa karete.

Matlapa ana a entsoe ka 'mala oa filimi ea enteric oa' mala o mosoeu kapa o batlang o le mosoeu, o chitja, biconvex, karolong ea sefapano - mookotaba oa 'mala o mosoeu kapa o batlang o le mosoeu le mokokotlo o moqotetsane.

1 tab
acetylsalicylic acid	75 mg

Bahlomphehi: lactose monohydrate - 47.25 mg, cellcose ea microcrystalline - 24,4 mg, colloidal silicon diode - 2.6 mg, sodium carboxymethyl starch - 0,75 mg.

Sebopeho sa Shell: Copolymer ea methaconic acid le ethyl acrylate 1: 1 - 6.7 mg, povidone K17 - 1.12 mg, talc - 1.5 mg, macrogol 4000 - 0.68 mg.

Li-pcs tse 10. - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (9) - lipakete tsa karete.
Li-pcs tse 30 - makotikoti a polymer (1) - lipakete tsa karete.
Likhomphutha tse 60. - makotikoti a polymer (1) - lipakete tsa karete.

Matlapa ana a entsoe ka 'mala oa filimi ea enteric oa' mala o mosoeu kapa o batlang o le mosoeu, o chitja, biconvex, karolong ea sefapano - mookotaba oa 'mala o mosoeu kapa o batlang o le mosoeu le mokokotlo o moqotetsane.

1 tab
acetylsalicylic acid	100 mg

Bahlomphehi: lactose monohydrate - 63 mg, microcrystalline cellulose - 32,6 mg, colloidal silicon diode - 3.4 mg, starch ea carboxymethyl ea sodium - 1 mg.

Sebopeho sa Shell: Copolymer ea methaconic acid le ethyl acrylate 1: 1 - 10.05 mg, povidone K17 - 1.68 mg, talc - 2.25 mg, macrogol 4000 - 1.02 mg.

Li-pcs tse 10. - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (9) - lipakete tsa karete.
Li-pcs tse 30 - makotikoti a polymer (1) - lipakete tsa karete.
Likhomphutha tse 60. - makotikoti a polymer (1) - lipakete tsa karete.

Ketso ea pharmacological

NSAIDs. E na le litlamorao tse khahlanong le ho ruruha, li-analgesic le antipyretic, hape e thibela ho kopanngoa ha liplatelete. Mochine oa ts'ebetso o amahanngoa le thibelo ea ts'ebetso ea COX - enzyme ea mantlha ea metabolism ea arachidonic acid, e leng moetapele oa li-prostaglandins, tse etsang karolo e kholo ho pathogeneis ea ho ruruha, bohloko le feberu. Ho fokotseha ha litaba tsa li-prostaglandins (haholo-holo E 1) bohareng ba thermoregulation ho lebisa ho fokotseha ha mocheso oa 'mele ka lebaka la ho eketsoa ha methapo ea mali letlalong le ho fufuleloa ho eketsehileng. Phello ea analgesic e bakiloe ke ketso ea bohareng le e bohareng. Fokotsa ho kopanya, ho khokhotheha ka liplatelete le thrombosis ka ho thibela ho hlophisoa ha thromboxane A 2 ka liplatelete.

Fokotsa lefu la motho le kotsi ea ho theoleloa ka bohloeki ba myocardial le angina e sa tsitsang. E atlehang ho thibelo ea mantlha ea mafu a pelo le methapo ea thibelo ea bobeli ea infarction ea myocardial. Ka tekanyetso ea letsatsi le letsatsi ea 6 g kapa ho feta, e thibela ho kopana ha prothrombin ka har'a sebete mme e eketsa nako ea prothrombin. E eketsa ts'ebetso ea plasma ea fibrinolytic mme e fokotsa mokokotlo oa lintlha tse amanang le ho ruruha ha vitamini (II, VII, IX, X). Ho eketsa mathata a hemorrhagic nakong ea ts'ebetso ea ho buoa, ho eketsa kotsi ea ho tsoa mali nakong ea kalafo ka li-anticoagulants. E hlohlelletsa excretion ea uric acid (e sitisa ho ts'oaroa ha eona ka har'a lipompo), empa e noe haholo. Blockade ea COX-1 ka mpeng ea gastric mucosa e lebisa ho thibelo ea li-prostaglandins tsa gastroprotective, tse ka lebisang ho lcrance ea membrane ea mucous le ho tsoa mali hamorao.

Mofumahali

Ha e nooa ka molomo, e kenella ka potlako haholo-holo ho tloha karolong e ka mpeng ea mala le ho ea hanyane ho tloha mpeng. Ho ba teng ha lijo ka mpeng ho fetola haholo ho kenngoa ha asiti ea acetylsalicylic.

E tšeloa ka har'a sebete ka hydrolysis ka sebopeho sa salicylic acid, e lateloe ke khokahano le glycine kapa glucuronide. Khetla ea salicylates plasma ea mali e fapana.

Ekaba 80% ea salicylic acid e tlama ho protheine ea plasma. Li-salicylates li kenella habonolo linthong tse ngata le maro a 'mele, ho kenyeletsoa ka har'a mokelikeli oa "cerebrospinal", peritoneal le synovial fluid. Ka tekanyo e nyane, li-salicylate li fumanoa lithong tsa boko, lits'oants'o - ka bile, mofufutso, mantle. E kenella ka potlako ka har'a sethopo sa placental, ka bongata bo fokolang bo kentsoeng lebeseng la matsoele.

Ho masea a sa tsoa hlaha, li-salicylate li ka tlosa bilirubin ho kopaneng le albin le ho kenya letsoho kholisong ea bilirubin encephalopathy.

Ho kenella kahare ho mothapo o kopaneng ho potlakisa boteng ba hyperemia le edema mme o fokotsa sekhahla sa ho ruruha.

Ha acidosis e etsahala, boholo ba salicylate bo fetoloa mofuta o sa amaneng le ionized, o kenang hantle linthongng, ho kenyeletsoa ho isa bokong.

E hlahisoa haholo-holo ke secretion e sebetsang mefuteng ea liphio e sa fetoheng (60%) le ka sebopeho sa metabolites. Mofuta oa salicylate e sa fetoloang o ipapisitse le pH ea moroto (ka moroto oa moroto, ionization ea li-salicylates li eketseha, makhopho a tsona a botjha a eketseha, 'me mantle a eketseha haholo). T 1 / acetylsalicylic acid e ka bang metsotso e 15. T 1/2 salicylate ha e nooa ka tekanyetso e tlase ke lihora tse 2-3, ka litekanyetso tse ntseng li eketseha e ka nyolohela ho lihora tse 15-30. Ho masea a sa tsoa hlaha, ho tlosoa ha salicylate ho lieha haholo ho feta ho batho ba baholo.

Matšoao a lithethefatsi

Rheumatism, rheumatoid arthritis, mafu a tšoaetsanoang le a allergic myocarditis, feberu ea mafu a tšoaetsanoang le a tšoaetsanoang, bohloko bo bobebe bo lekaneng ba methapo e fapaneng (ho kenyeletsa neuralgia, myalgia, hlooho), thibelo ea thrombosis le embolism, thibelo ea mantlha le ea bobeli , thibelo ea likotsi tsa cerebrovascular ho latela mofuta oa ischemic.

Thutong ea bongaka ea mafu a mafu a mafu a nko le allergology: butle-butle litekanyetso tsa "aspirin" tsa nako e telele le tlholeho ea mamello e tsitsitseng ho li-NSAIDs ho bakuli ba nang le "asthma" ea "aspirin" le "asipirin triad"

Khoutu tsa ICD-10

Khoutu ea ICD-10	Pontšo
I21	Acal myocardial infarction
I40	Acyo myocarditis
I63	Mofuta oa khoheli
I74	Embolism le arterial thrombosis
I82	Embolism le thrombosis ea methapo e meng
M05	Seropositive Rheumatoid Arthritis
M79.1	Myalgia
M79.2	Neuralgia le lefu la mokokotlo le sa hlalosoang
R50	Feberu e sa hloekang
R51	Ho opeloa ke hlooho
R52.0	Mahlaba a bohloko
R52.2	Bohloko bo bong bo sa feleng (bo sa foleng)

Litla-morao

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, ho ipolaisa tlala, ho opeloa ke lets'ollo, lets'ollo, ka seoelo - ho hlaha ha leqeba la ho ruruha le liso, ho tsoa madi ho tsoa mokokotlong, ho senyeha hoa ts'ebetso ea sebete.

Ho tloha lehlakoreng la ts'ebetso ea methapo e bohareng: ka tšebeliso ea nako e telele, ho tsekela, ho opeloa ke hlooho, ho sitisoa ha pono, tinnitus, andeptic meningitis.

Ho tsoa ho sistimi ea hemopoietic: ka seoelo - thrombocytopenia, anemia.

Ho tsoa tsamaisong ea mali ea mali: ka seoelo - hemorrhagic syndrome, e lelefatsa nako ea ho tsoa mali.

Ho tsoa ts'ebetsong ea moroto: ka seoelo - ts'ebetso ea renal e sa sebetseng hantle, e nang le tšebeliso ea nako e telele - ho hloleha ho hlaphoheloang ke methapo, le nephrotic syndrome.

Litlamorao: ka seoelo - lekhopho la letlalo, lefu la Quincke, bronchospasm, "aspirin triad" (motsoako oa asthma ea bronchial, polyposis ea nko le liphoso tsa paranasal le ho se mamelle lithethefatsi tsa acetylsalicylic acid le pyrazolone).

Tse ling: maemong a mang - Boloetse ba Reye, bo nang le tšebeliso ea nako e telele - matšoao a matla a ho hloleha ha pelo ho sa foleng.

Bokhachane le pelehi

E ngotsoe ka kotloloho ho boimana ba I le III. Ho "trimester" ea bobeli ea bokhachane, ho amoheloa ka mokhoa o le mong ho ka etsahala ho latela lipontšo tse hlakileng.

E na le phello ea teratogenic: ha e sebelisoa ho trimester ea pele, e lebisa ho nts'etsopele ea khalare e kaholimo, ho trimester ea boraro e baka tšenyo ea mosebetsi (inhibition of prostaglandin synthesis), ho koaloa kapele ha ductus arteriosus ka popelong, pulmonary vascular hyperplasia le methapo ea mali methapo ea mali maling.

Acetylsalicylic acid e tšeloa ka lebese la matsoele, e leng se eketsang kotsi ea ho tsoa mali ho ngoana ka lebaka la ts'ebetso ea mokokotlo o senyehileng, ka hona, mme ha a lokela ho sebelisa acetylsalicylic acid nakong ea lebese.

Litaelo tse khethehileng

E sebelisoa ka mokhoa o hlokolosi ho bakuli ba nang le mafu a sebete le a liphio, le asthma ea bronchial, lesapo la mokokotlo le liso le mali ho tsoa mokokotlong oa mpa ka anamnesis, ka mali a tsoang kapa ka kalafo e tšoanang, e sa sebetseng ea pelo e sa foleng.

Acetylsalicylic acid esita le ho litekanyetso tse nyane e fokotsa ho nona ha uric acid e tsoang 'meleng, e ka bakang tlhaselo e matla ea gout ho bakuli ba kotsing. Nakong ea phekolo ea nako e telele le / kapa ts'ebeliso ea acetylsalicylic acid ho litekanyetso tse phahameng, ho hlokahala hore a be leihlo le kalafo le ho lekola maemo a hemoglobin kamehla.

Ts'ebeliso ea acetylsalicylic asiti e le moemeli ea thibelang ho ruruha lethal dose ea letsatsi le letsatsi ea 5-8 g e lekanyelitsoe ka lebaka la menyetla e mengata ea litla-morao tse tsoang mpeng ea gastrointestinal.

Pele o buuoa, ho fokotsa ho tsoa mali nakong ea ts'ebetso le nakong ea ts'ebetso, o lokela ho emisa ho nka salicylates ka matsatsi a 5-7.

Nakong ea kalafo ea nako e telele, tlhahlobo ea mali e akaretsang le tlhahlobo ea mali ea mohlolo e lokela ho etsoa.

Ts'ebeliso ea asiti ea acetylsalicylic acid ho bana e hatelloa, hobane maemong a ts'oaetso ea vaerase baneng e tlas'a tšusumetso ea acetylsalicylic acid, menyetla ea ho ba le lefu la Reye e eketseha. Matšoao a lefu la Reye a kenyelletsa ho hlatsa ka nako e telele, ho ruruha haholo ka ho ruruha le ho ruruha ha sebete.

Nako ea kalafo (ntle le ho buisana le ngaka) ha ea lokela ho feta matsatsi a 7 ha e laetsoe e le analgesic le matsatsi a fetang a 3 e le antipyretic.

Nakong ea kalafo, mokuli o lokela ho hana ho noa joala.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea li-antacids tse nang le magnesium le / kapa aluminium hydroxide, fokotsa butle le ho fokotsa ho monya ha acetylsalicylic acid.

Ka tšebeliso e tšoanang ea calcium calcium blockers, lithethefatsi tse fokotsang ho ja calcium kapa ho eketsa khalori ea calcium e tsoang 'meleng, menyetla ea ho tsoa mali e eketseha.

Ka tšebeliso e tšoanang le acetylsalicylic acid, phello ea heparin le anticoagulants e sa tobang, li-agents tsa hypoglycemic tsa sulfonylureas, insulin, methotrexate, phenytoin, valproic acid e matlafatsoa.

Ka ts'ebeliso e ts'oanang le corticosteroids, kotsi ea ketso ea ulcerogenic le ho hlaha ha mali a tsoang ka mpeng li eketseha.

Ka tšebeliso e tšoanang, katleho ea diuretics (spironolactone, furosemide) e ea fokotsoa.

Ka tšebeliso e tšoanang ea li-NSAID tse ling, kotsi ea litlamorao e ea eketseha. Acetylsalicylic acid e ka fokotsa likhakanyo tsa plasma tsa indomethacin, piroxicam.

Ha e sebelisoa ka mokhoa o ts'oanang le litokisetso tsa khauta, asiti ea acetylsalicylic e ka baka tšenyo ea sebete.

Ka tšebeliso e ts'oanang, ts'ebetso ea li-uricosuric agents e fokotseha (ho kenyelletsa le phenenecid, sulfinpyrazone, benzbromarone).

Ka tšebeliso e tšoanang ea acetylsalicylic acid le sodium alendronate, nts'etsopele ea esophagitis e matla e ka khonahala.

Ka tšebeliso e tšoanang ea griseofulvin, tlolo ea ho amoheloa ha asiti ea acetylsalicylic acid e ka etsahala.

Nyeoe ea hemorrhage e itlhahelang iris ha e nka mothapo oa ginkgo biloba khahlanong le semelo sa tšebeliso ea nako e telele ea acetylsalicylic acid ka lethal dose ea 325 mg / ka letsatsi e hlalositsoe. Ho lumeloa hore sena se ka bakoa ke phello ea tlatsetso ea inhibitory ho kopaneng ea liplatelete.

Ka ts'ebeliso e le 'ngoe ea dipyridamole, keketseho ea C max ea salicylate ho plasma ea mali le AUC e khonahala.

Ka tšebeliso e le 'ngoe le acetylsalicylic acid, likhahla tsa digoxin, barbiturates le lithaelese tsa lithium keketseho ea plasma ea mali.

Ka tšebeliso e tšoanang ea li-salicylate ka tekanyetso e phahameng le li-inhibitors tsa khalicone, ho ka khoneha ho matahanya salicylate.

Acetylsalicylic acid ho litekanyetso tse ka tlase ho 300 mg / ka letsatsi e na le phello e sa tsotelleng mabapi le katleho ea Captopril le enalapril. Ha o sebelisa acetylsalicylic acid ho tekanyetso e phahameng, ho fokotseha ha katleho ea Captopril le enalapril hoa khoneha.

Ka tšebeliso ea nako e tšoanang ea caffeine e eketsa tekanyo ea ho monya, mahloriso a plasma le bioavailability ea acetylsalicylic acid.

Ka tšebeliso e tšoanang ea metoprolol e ka eketsa C max salicylate maling a mali.

Ha o sebelisa pentazocine khahlano le tšebeliso ea nako e telele ea acetylsalicylic acid ho litekanyetso tse phahameng, ho na le monyetla oa ho ba le karabelo e mpe lipelong.

Ka tšebeliso e tšoanang ea phenylbutazone e fokotsa uricosuria e bakoang ke acetylsalicylic acid.

Ka tšebeliso e tšoanang ea ethanol e ka ntlafatsa phello ea acetylsalicylic acid e phepelong ea tšilo ea lijo.

Tlhophiso ea Nosological (ICD-10)

Matlapa a Kopaneng a kopantsoeng	1 tab.
ntho e sebetsang:
acetylsalicylic acid	50/75/100 mg
sepheo sa mantlha: lactose monohydrate - 31.5 / 47.25 / 63 mg, MCC - 16.30 / 24.4 / 32.6 mg, colloidal silicon diode - 1.7 / 2.6 / 3.4 mg, sodium carboxymethyl - 0,7 5 / 0.75 / 1 mg
film sheath: kopolymer ea methaconic acid le ethyl acrylate (1: 1) - 3.35 / 6.7 / 10.05 mg, povidone K17 - 0.56 / 1.12 / 1.68 mg, talc - 0.75 / 1.5 / 2.25 mg, macrogol 4000 - 0.34 / 0.68 / 1.02 mg

Mofumahali

Mochine oa ts'ebetso oa acetylsalicylic acid (ASA) o thehiloe ho thibelo e ke keng ea fetoloa ea COX-1, ka lebaka leo motsoako oa PG, prostacyclins le Tx o thibetsoeng. Fokotsa ho kopanya, ho khokhotheha ka liplatelete, le thrombosis ka ho hatella motsoako oa TxA2 ka liplatelete. E eketsa ts'ebetso ea fibrinolytic ea plasma ea mali mme e fokotsa mokokotlo oa lintho tse amanang le tlhaho tsa koae (K, VII, IX, X). Matla a antiplatelet a boleloa haholo liplatlemeng, hobane ha ba khone ho kopanya COX hape. Matla a antiplatelet a hlaha kamora ts'ebeliso ea litekanyetso tse nyane tsa moriana 'me a phehella matsatsi a 7 kamora tekanyetso e le' ngoe. Mefuta ena ea ASA e sebelisoa ho thibela le kalafo ea myocardial infarction, lefu la pelo le mathata a methapo ea varicose. ASA e boetse e na le anti-inflammatory, analgesic, antipyretic effect.

Contraindication

hypersensitivity ho acetylsalicylic acid, ba ipabolang ka sebopeho sa lithethefatsi le li-NSAID tse ling,

liso tsa maqeba le tsa maqeba tsa mokokotlong (karolong e mpe ea mpa),

Asthma ea bronchial e susumetsoang ke ho nka li-salicylates le li-NSAID tse ling,

motsoako oa asthma ea bronchial, polyposis e sa phetseng hantle ea nko le sinanasale le ho mamellana ha ASA,

Motsoako o kopantsoeng le methotrexate lethalong la 15 mg / beke kapa ho feta,

ho hloleha ho matla ha renal (Cl creatinine e ka tlase ho 30 ml / min),

ho hloleha ho matla ha sebete (sehlopha sa B le kaholimo ho sekhahla sa bana),

lefu la pelo le sa foleng la III - Sehlopha sa IV se sebetsang ho latela sehlopha NYHA,

lactose ho hloka mamello, khaello ea lactase, tsoekere / galactose malabsorption (lithethefatsi li na le lactose monohydrate),

boimana (I le borikhoe ba III),

nako ea ho anyesa,

lilemo tse 18.

Ka tlhokomelo: gout, hyperuricemia, leqeba la ka mpeng le duodenal kapa nalane ea ho tsoa mali ka mpeng (ho se sebetse hantle hoa mokokotlo), ho se sebetse hantle ha masapo (creatinine Cl ho feta 30 ml / min), mathata a CVD (ho kenyelletsa ho hloleha ha pelo ho sa foleng, hypovolemia, ts'ebetso e matla ea ho buoa ho kenella, sepsis kapa linyeoe tsa ho tsoa mali ho hoholo - kotsi ea ho holofala le ho hloleha ha methapo ka mpeng), ho se sebetse hantle ha sebete (ka tlase ho sehlopha B ho sekhahla sa ngoana), lefu la bronchial, mafu a setho sa 'mele phefumoloho, feberu ea furu, polyposis ea ka mpeng, ho kulisoa hoa lithethefatsi, ho kenyeletsa Li-NSAID, li-analgesics, li-anti-inflammatory, antirheumatic agents, khatello e matla ea glucose-6-phosphate dehydrogenase (ASA e ka baka lefu la hemolysis le hemolytic anemia, mabaka a ka eketsang kotsi ea hemolysis ke lethal dose le phahameng la lithethefatsi, feberu le tšoaetso e mpe). trimester), ts'ebetso e buelletsoeng ea ho buoa (ho kenyeletsoa le e menyenyane, ho etsa mohlala, ho ntšuoa ha meno), tsamaiso ka nako e le 'ngoe le methotrexate ka tekanyetso e ka tlase ho 15 mg / beke, anticoagulants, agents tsa thrombolytic kapa antiplatelet le ho bolela, NSAIDs le salicylic derivatives acid e ka tekanyetso e phahameng, digoxin, hypoglycemic mahlahana bakeng sa ho sebelisoa ka molomo (sulfonylurea derivatives) le a ntse insulin, acid e valproic, joala (haholo-holo lino tse tahang), SSRIs, ibuprofen (cm,. "sebelisana").

Litlamorao

Ho tsoa ts'ebetsong ea tšilo ea lijo: khafetsa - ho nyekeloa ke pelo, ho opeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, ka seoelo - liso tsa ka mpeng le litšoelesa tsa tsebetso, ho ruruha ha mali ka mpeng, ho senyeha hoa nakoana ka ts'ebetso e eketsehileng ea liprotheine tsa hepatic.

Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: ho tsekela, ho se utloe hantle litsebeng, tinnitus, eo e ka bang sesupo sa lithethefatsi tse ngata (sheba "Overdose").

Ho tsoa ho sheropoietic system: khafetsa khafetsa ea mali a perioperative (intra- le postoperative), hematomas (maqeba), nosebleeds, likotsi tsa mali, mali a tsoang mali. Ho na le litlaleho tsa likotsi tse tebileng tsa ho tsoa mali, tse kenyeletsang ho tsoa mali le mokokotlo oa mokokotlo (haholo-holo ho bakuli ba nang le khatello ea mali ea methapo ba sa kang ba fihlela sepheo sa khatello ea mali le / kapa ba amohela kalafo e kopaneng le lithethefatsi tsa anticoagulant), tseo maemong a mang li ka behang bophelo kotsing. . Ho tsoa mali ho ka lebisa nts'etsopele ea anemia e mpe kapa e sa foleng ea khaello ea tšepe (mohlala, ka lebaka la ho tsoa mali) le matšoao a amanang le kliniki le a laboratori (asthenia, pallor, hypoperfusion). Ho na le litlaleho tsa maemo a haemolysis le anemia ea hemolytic ho bakuli ba nang le khaello e matla ea glucose-6-phosphate dehydrogenase.

Litla-morao: lekhopho la letlalo, ho hlohlona, ​​uritisaria, edema ea Quincke, rhinitis, ho ruruha ha mucous membrane ea mucous ea nko, bronchospasm, lefu la pelo le khatello ea maikutlo le karabelo e matla, ho kenyelletsa ho thothomela hoa anaphylactic.

Ho tsoa ts'ebetsong ea moroto: ho na le litlaleho tsa linyeoe tsa ho se sebetse hantle ha rems le ho hloleha ha reef haholo.

Tšebelisano

Ka tšebeliso e tšoanang ea ASA e ntlafatsa litlamorao tsa lithethefatsi tse thathamisitsoeng ka tlase. Haeba ho hlokahala, ho khethoa ha nako e le ngoe ha ASA le chelete e thathamisitsoeng ho lokela ho nahana ka tlhoko ea ho fokotsa tekanyetso ea bona:

- methotrexate - ka lebaka la ho fokotseha ha clearance renal le ho falla ha eona ho tsoa puisanong le liprotheine,

- anticoagulants, thrombolytic le antiplatelet agents (ticlopidine) - ho na le menyetla ea ho tsoa mali ka lebaka la synergism ea litlamorao tse kholo tsa kalafo tse sebelisitsoeng ke lithethefatsi,

- lithethefatsi tse nang le anticoagulant, thrombolytic kapa antiplatelet, - ho na le keketseho ea phello e senyang mucosa ea ka mpeng,

- SSRIs - e ka lebisa kotsing e kholo ea ho tsoa mali ho tsoa mokokotlong o ka holimo oa mpa (synergism le ASA),

- digoxin - ka lebaka la ho fokotseha ha popo ea eona ea renal, e ka lebisang ho overdose,

- li-hypoglycemic agents tsa tsamaiso ea molomo (sulfonylurea derivatives) le insulin ka lebaka la thepa ea ASC ka boeona e noeng ka tekanyo e phahameng le ho tlosoa hoa liphihlelo tsa sulfonylurea mokhatlong o nang le liprotheine tsa plasma tsa mali,

- valproic acid - - chefo ea eona e eketseha ka lebaka la ho falla ho eona ho tsoa lipuisanong le liprotheine tsa plasma ea mali,

- Li-NSAID le li-acid tse nang le letsoai la salicylic ka tekanyetso e phahameng - kotsi e eketsehang ea phello ea ulcerogenic le ho tsoa mali ho tsoa ho tšilo ea lijo ka lebaka la ts'ebetso ea synergism.

- ibuprofen - ho na le mohanyetsi mabapi le thibelo e ke keng ea fetoloa ea thromboxanesynthetase ka lebaka la ketso ea ASA, e lebisang ho fokotseheng hoa litlamorao tsa phello ea pelo le ASA,

- ethanol - kotsi e eketsehileng ea ho senya mucosa ea ka mpeng le ho lelefatsa nako ea ho tsoa mali ka lebaka la ntlafatso ea litlamorao tsa ASA le ethanol.

Ts'ebetso e ts'oanang ea ASA ka tekanyetso e phahameng e ka fokolisa phello ea litlhare tse thathamisitsoeng ka tlase. Haeba ho hlokahala, ho khethoa ha nako e le ngoe ha ASA le chelete e thathamisitsoeng ho lokela ho nahana ka tlhoko ea tokiso ea tekanyetso:

- diuretics efe kapa efe - ho na le ho fokotseha hoa GFR ka lebaka la ho fokotseha ha motsoako oa li-GHG lipelong,

- ACE inhibitors - ho na le ho fokotseha hoa tekanyo-tekano ho GFR ka lebaka la thibelo ea li-GHG ka phello ea vasodilating, ka ho latellana, ho fokolisa hoa phello ea hypotensive. Ho fokotseha ha kliniki ho GFR ho bonoa ka tekanyetso ea letsatsi le letsatsi ea ASA e fetang 160 mg. Ntle le moo, ho na le ho fokotseha hoa phello e ntle ea cardioprotective ea ACE inhibitors e abetsoeng bakuli bakeng sa kalafo ea ho nyekeloa ke pelo. Matla ana a bonahala hape ha a sebelisoa hammoho le ASA ho tekanyetso e kholo,

- lithethefatsi tse nang le ts'ebetso ea uricosuric (benzbromaron, probenecid) - ho fokotseha hoa phello ea uricosuric ka lebaka la khatello ea tlholisano ea renal tubular urinary acid excretion,

- systemic GCS (ntle le hydrocortisone e sebelisitsoeng bakeng sa pheko ea lefu la Addison) - ho na le keketseho ea tlhahiso ea li-salicylates, 'me ka lebaka leo, ho fokolisa tšebetso ea tsona.

Tekanyetso le tsamaiso

Ka hare ntle le ho hlafuna, ho nwa metsi a mangata, ka ho khetheha pele ho lijo. Matlapa a nkuoa 1 nako ka letsatsi.

Nako ea kalafo e khethoa ke ngaka e eang.

Thibelo ea mantlha ea infarate e mpe ea myocardial ka pel'a lintho tse ka behang kotsing. 50-100 mg / ka letsatsi.

Thibelo ea infraction ea myocardial e sa khaotseng, e sa tsitsang le e tsitsitseng ea angina pectoris. 50-100 mg / ka letsatsi.

Angina e sa tsitsang (e nang le belaello ea infraction e mpe ea myocardial). Tekanyetso ea pele ea 100 mg (Letlapa la pele le tlameha ho hlafuneloa bakeng sa ho kenngoa ka potlako) e lokela ho nkuoa ke mokuli kapele kamoo ho ka khonehang kamora ho belaela ka nts'etsopele ea infarction ea myocardial e mpe. Matsatsing a 30 a latelang ka mor'a nts'etsopele ea myocardial infarction, lethal la 200-300 mg / letsatsi le lokela ho bolokoa. Kamora matsatsi a 30, kalafo e nepahetseng e lokela ho laeloa ho thibela infarction ea myocardial.

Thibelo ea ho hlaseloa ke lefu la sethoathoa le lefu la nakoana la mokokotlo. 75-100 mg / ka letsatsi.

Thibelo ea thromboembolism ka mor'a ho buuoa le ho kenella ka hare ho methapo ea methapo. 50-100 mg / ka letsatsi.

Thibelo ea DVT le pulmonary embolism le makala a eona. 100-200 mg / ka letsatsi.

Foromo ea boholo:

matlapa a koahetsoeng ka enteric

Letlapa le leng le na le:

acetylsalicylic acid - 50.00 mg, 75.00 mg kapa 100.00 mg.

Baeti (bohareng):

lactose monohydrate - 31.50 mg, 47.25 mg kapa 63,00 mg, cellcrystalline cellulose - 16.30 mg, 2440 mg kapa 32.60 mg, colloidal silicon diode - 1,70 mg, 2.60 mg kapa 3.40 mg; sodium carboxymethyl starch 0,50 mg, 0,75 mg kapa 1,00 mg.

Baeti (shell):

Copolymer ea methaconic acid le ethyl acrylate 1: 1 - 3.35 mg, 6.70 mg kapa 10,05 mg, povidone K17 - 0.56 mg, 1.12 mg kapa 1.68 mg, talc - 0.75 mg, 1 , 50 mg kapa 2.25 mg, macrogol 4000 - 0.34 mg, 0.68 mg kapa 1,02 mg.

Matlapa a pota-potileng, a biconvex, filimi e tlotsitsoeng ea enteric, e tšoeu kapa e batlang e tšoeu. Karolong ea sefapano: mantlha e tšoeu kapa e batla e le tšoeu ebile e na le leqhubu le lenyane.

Bongata

E ka ba le litlamorao tse mpe, haholoholo ho bakuli ba tsofetseng le ho bana.

Salicylism syndrome e hlaha ha motho a nka ASA ka tekanyetso ea fetang 100 mg / kg / letsatsi bakeng sa matsatsi a fetang a mabeli ka lebaka la tšebeliso ea litekanyetso tse nang le chefo e le karolo ea ts'ebeliso e fosahetseng ea kalafo (chefo e sa foleng) kapa ts'ebetso e le 'ngoe ea tšebeliso ea lithethefatsi ho motho e moholo kapa ngoana. .

Bonolo ho leka-lekanya boima (tekanyetso e le 'ngoe e ka tlase ho 150 mg / kg)

Matšoao ho tsekela, ho tsitsipanya, ho se utloe litsebeng, ho fufuleloa ho eketsehileng, ho nyekeloa le pelo le ho hlatsa, hlooho, pherekano, tachypnea, hyperventilation, alkalosis ea ho hema.

Phekolo: phokotso ea ka mpeng, tsamaiso e pheta-phetoang ea khabone e hlahisitsoeng, e qobelloang alkaline diuresis, tsosoloso ea tekano ea motlakase oa motlakase le KShchS.

Tekanyo e bohareng le e matla (tekanyetso e le 'ngoe ea 150-300 mg / kg - boima bo lekaneng, ho feta 300 mg / kg - chefo e matla)

Matšoao alkalosis ea ho phefumoloha ka komporo ea metabolic acidosis, hyperpyrexia, hyperventilation, non-Cardiogenic pulmonary edema, khatello ea maikutlo a moea, asphyxia, ka lehlakoreng la CCC - pelo le arrhythmias, e tšoaeang ho fokotseha ha khatello ea mali, thibelo ea ts'ebetso ea pelo, karolong ea matla a methapo ea methapo ea metsi. ho fihlela nts'etsopele ea ho se sebetse hantle ha masapo, a tšoauoang ke hypokalemia, hypernatremia, hyponatremia, metabolism ea tsoekere ea glucose - hyperglycemia, hypoglycemia (haholoholo baneng). etoatsidoz, tinnitus, botholo, gastrointestinal hemorrhage, hematological mafu a - ka thibelo ya aggregation platelet ho coagulopathy leo, PX katoloso, hypoprothrombinemia, methapo ea kutlo maloetse - chefo magazine le khatello ea tsamaiso ea bohareng methapo (otsela, pherekano, coma, tsitsipana).

Phekolo: sepetlele hanghang mafapheng a ikhethileng bakeng sa kalafo ea tšohanyetso - lavage ea gastric, taolo e pheta-phetoang ea mashala a ts'ebetso, khatello ea alkaline digesis, hemodialysis, tsosoloso ea tekano ea metsi-electrolyte le acid-base balance, kalafo ea matšoao.

Moetsi

Moqapi / mokhatlo o amohelang litletlebo tsa bareki: OJSC Irbit Chemical Farm. 623856, Russia, sebaka sa Sverdlovsk, Irbit, st. Kirova, 172.

Tel./fax: (34355) 3-60-90.

Aterese ea tlhahiso: Sverdlovsk Setereke, Irbit, ul. Karl Marx, 124-a.

Setheo sa molao lebitsong leo lengolo la setifikeiti se fanoeng: OAO Aveksima. 125284, Russia, Moscow, tebello ea Leningradsky, 31A, leq. 1.

Matšoao a ho sebelisoa

Thutong ea bongaka ea mafu a mafu a mafu le ho allergology: butle-butle litekanyetso tsa "aspirin" tsa nako e telele le tlholeho ea mamello e tsitsitseng ho li-NSAIDs ho bakuli ba nang le asthma ea "aspirin" le "asipirin triad"

Feverish syndrome ho mafu a tšoaetsanoang le a tšoaetsanoang.

Pain syndrome (ea limelo tse fapaneng): hlooho ea hlooho (ho kenyelletsa le e amanang le lefu la ho itlopa joala), migraine, leino le opang, neuralgia, lumbago, radicular radicular syndrome, myalgia, arthralgia, algodismenorea.

Joalo ka sethethefatsi sa antiplatelet (tekanyetso e fihla ho 300 mg / letsatsi): lefu la pelo, ho ba teng hoa lintlha tse 'maloa tsa lefu la pelo, bohloko bo sa tsitsang ba Angina pectoris, myocardial infarction (ho fokotsa kotsi ea boipheliso ba myocardial infarction le lefu kamora lefutso la myocardial). lets'ollo ho banna, li-valves tsa pelo tsa maiketsetso (thibelo le kalafo ea thromboembolism), balloon coronary angioplasty le ho behoa hoa setonana (ho fokotsa kotsi ea ho ts'oaroa hape hoa lefu la stenosis le kalafo ea stratification ea sekhahla sa methapo ea mokokotlo), ka atheros lesapo la mokokotlo la mokokotlo oa mokokotlo oa mokokotlo (coralary artery (lefu la Kawasaki), aortoarteritis (lefu la Takayasu), mathata a pelo le methapo ea methapo ea lefu la mokokotlo, mitral valve prolapse (thibelo ea thromboembolism), embolism ea methapo, pulmonary infarction, pulmonary infarction, acute thrombophlebitis,

Rheumatism, rheumatoid arthritis, myocarditis e tšoaetsanoang, pericarditis, rheumatic chorea - ha e sa sebelisoa ..

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Matlapa a moriana o nooa ka molomo, a na le lefu la ho kuta le bohloko ho batho ba baholo - 0.5-1 g / ka letsatsi (ho fihlela ho 3 g), le arotsoe ka litekanyetso tse tharo. Nako ea kalafo ha ea lokela ho feta libeke tse 2.

Ho ntlafatsa maemo a rheological a mali - 0,15-0.25 g / letsatsi ka likhoeli tse 'maloa.

Matlapa a nang le ASA ho litekanyetso tse kaholimo ho 325 mg (400-500 mg) a etselitsoe ho sebelisoa e le sethethefatsi sa analgesic le se thibelang mafu, litekanyetso tsa 50-75-100-300-325 mg ho batho ba baholo, haholo-holo e le lithethefatsi tsa antiplatelet.

Ka infraction ea myocardial, hammoho le thibelo ea bobeli ho bakuli kamora lefu la myocardial infarction, 40-325 mg hang ka letsatsi (hangata 160 mg). Joalo ka inhibitor ea platelet aggregation - 300-325 mg / letsatsi ka nako e telele.Ka mathata a matla a "cerebrovascular" ho banna, "cerebral thromboembolism" - 325 mg / letsatsi ka keketseho ea butle-butle ho isa ho 1 g / letsatsi, bakeng sa ts'ireletso ea ho khutla - 125-300 mg / letsatsi. Bakeng sa thibelo ea "thrombosis" kapa "occlusion" ea aortic shunt, ka makhetlo a 325 mg, lihora tse ling le tse ling tse 7 ka mokokotlong oa gastric ea gastric, ebe 325 mg ka molomo ka makhetlo a 3 ka letsatsi (hangata e kopantsoe le dipyridamole, e hlakotsoeng kamora beke, ho tsoela pele kalafo le nako e telele).

Ka rheumatism e sebetsang e ne e laetsoe (hajoale e sa laeloe) ka tekanyetso ea letsatsi le letsatsi ea 5-8 g bakeng sa batho ba baholo le 100-125 mg / kg bakeng sa bacha (lilemo tse 15-18), khafetsa ea tšebeliso ke makhetlo a 4-5 ka letsatsi. Kamora libeke tse 1-2 tsa kalafo, bana ba fokotseha tekanyetso ho ea ho 60-70 mg / kg / ka letsatsi, kalafo ea batho ba baholo e ntse e tsoela pele ka tekanyetso e le 'ngoe, nako ea kalafo e fihla ho libeke tse 6. Ho hlakola ho etsoa butle butle ka nako ea libeke tse 1-2.

Lipotso, likarabo, litlhahlobo ho Sanovask ea lithethefatsi

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebeletsang e le sebaka sa boipiletso ba motho ho setsebi.

Sebopeho le mofuta oa tokollo

Matlapa - Letlapa le le leng:

• Lintho tse sebetsang: acetylsalicylic acid 50 mg,
• Baeti: Bafani: lactose monohydrate - 31,5 mg, cellcrystalline cellulose - 16,3 mg, colloidal silicon diode - 1,7 mg, sodium carboxymethyl starch - 0.5 mg,
• Sebopeho sa khetla: Copolymer ea methaconic acid le ethyl acrylate 1: 1 - 3.35 mg, povidone K17 - 0.56 mg, talc - 0.75 mg, macrogol 4000 - 0.34 mg.

Matlapa a 30 ka pakete e ngoe le e ngoe.

Matlapa ana a entsoe ka 'mala oa filimi ea enteric oa' mala o mosoeu kapa o batlang o le mosoeu, o chitja, biconvex, karolong ea sefapano - mookotaba oa 'mala o mosoeu kapa o batlang o le mosoeu le mokokotlo o moqotetsane.

NSAIDs. E na le litlamorao tse khahlanong le ho ruruha, li-analgesic le antipyretic, hape e thibela ho kopanngoa ha liplatelete. Mochine oa ts'ebetso o amahanngoa le thibelo ea ts'ebetso ea COX - enzyme ea mantlha ea metabolism ea arachidonic acid, e leng moetapele oa li-prostaglandins, tse etsang karolo e kholo ho pathogeneis ea ho ruruha, bohloko le feberu. Ho fokotseha ha litaba tsa li-prostaglandins (haholo-holo E1) bohareng ba thermoregulation ho lebisa ho fokotseha ha mocheso oa 'mele ka lebaka la ho eketsoa ha methapo ea mali ea letlalo le mofufutso o eketsehang. Phello ea analgesic e bakiloe ke ketso ea bohareng le e bohareng. E fokotsa ho kopanya, ho khokhotheha ka liplatelete le thrombosis ka ho thibela ho kopana ha thromboxane A2 ka liplatelete.

Fokotsa lefu la motho le kotsi ea ho theoleloa ka bohloeki ba myocardial le angina e sa tsitsang. E atlehang ho thibelo ea mantlha ea mafu a pelo le methapo ea thibelo ea bobeli ea infarction ea myocardial. Ka tekanyetso ea letsatsi le letsatsi ea 6 g kapa ho feta, e thibela ho kopana ha prothrombin ka har'a sebete mme e eketsa nako ea prothrombin. E eketsa ts'ebetso ea plasma ea fibrinolytic mme e fokotsa mokokotlo oa lintlha tse amanang le ho ruruha ha vitamini (II, VII, IX, X). Ho eketsa mathata a hemorrhagic nakong ea ts'ebetso ea ho buoa, ho eketsa kotsi ea ho tsoa mali nakong ea kalafo ka li-anticoagulants. E hlohlelletsa excretion ea uric acid (e sitisa ho ts'oaroa ha eona ka har'a lipompo), empa e noe haholo. Blockade ea COX-1 ka mpeng ea gastric mucosa e lebisa ho thibelo ea li-prostaglandins tsa gastroprotective, tse ka lebisang ho lcrance ea membrane ea mucous le ho tsoa mali hamorao.

Ha e nooa ka molomo, e kenella ka potlako haholo-holo ho tloha karolong e ka mpeng ea mala le ho ea hanyane ho tloha mpeng. Ho ba teng ha lijo ka mpeng ho fetola haholo ho kenngoa ha asiti ea acetylsalicylic.

E tšeloa ka har'a sebete ka hydrolysis ka sebopeho sa salicylic acid, e lateloe ke khokahano le glycine kapa glucuronide. Khetla ea salicylates plasma ea mali e fapana.

Ekaba 80% ea salicylic acid e tlama ho protheine ea plasma. Li-salicylates li kenella habonolo linthong tse ngata le maro a 'mele, ho kenyeletsoa ka har'a mokelikeli oa "cerebrospinal", peritoneal le synovial fluid. Ka tekanyo e nyane, li-salicylate li fumanoa lithong tsa boko, lits'oants'o - ka bile, mofufutso, mantle. E kenella ka potlako ka har'a sethopo sa placental, ka bongata bo fokolang bo kentsoeng lebeseng la matsoele.

Ho masea a sa tsoa hlaha, li-salicylate li ka tlosa bilirubin ho kopaneng le albin le ho kenya letsoho kholisong ea bilirubin encephalopathy.

Ho kenella kahare ho mothapo o kopaneng ho potlakisa boteng ba hyperemia le edema mme o fokotsa sekhahla sa ho ruruha.

Ha acidosis e etsahala, boholo ba salicylate bo fetoloa mofuta o sa amaneng le ionized, o kenang hantle linthongng, ho kenyeletsoa ho isa bokong.

E hlahisoa haholo-holo ke secretion e sebetsang mefuteng ea liphio e sa fetoheng (60%) le ka sebopeho sa metabolites. Mofuta oa salicylate e sa fetoloang o ipapisitse le pH ea moroto (ka moroto oa moroto, ionization ea li-salicylates li eketseha, makhopho a tsona a botjha a eketseha, 'me mantle a eketseha haholo). T1 / 2 ea acetylsalicylic acid e ka bang metsotso e 15. T1 / 2 ea salicylate ha e nooa ka tekanyetso e tlase ke lihora tse 2-3, ha tekanyetso e eketseha e ka nyolohela ho lihora tse 15-30. Ho masea a sa tsoa hlaha, ho felisoa ha salicylate ho lieha haholo ho feta ho batho ba baholo.

Tšebeliso ea Sanovask ho ima le bana

E ngotsoe ka kotloloho ho boimana ba I le III. Ho "trimester" ea bobeli ea bokhachane, ho amoheloa ka mokhoa o le mong ho ka etsahala ho latela lipontšo tse hlakileng.

E na le phello ea teratogenic: ha e sebelisoa ho trimester ea pele, e lebisa ho nts'etsopele ea khalare e kaholimo, ho trimester ea boraro e baka tšenyo ea mosebetsi (inhibition of prostaglandin synthesis), ho koaloa kapele ha ductus arteriosus ka popelong, pulmonary vascular hyperplasia le methapo ea mali methapo ea mali maling.

Acetylsalicylic acid e tšeloa ka lebese la matsoele, e leng se eketsang kotsi ea ho tsoa mali ho ngoana ka lebaka la ts'ebetso ea mokokotlo o senyehileng, ka hona, mme ha a lokela ho sebelisa acetylsalicylic acid nakong ea lebese.

Contraindication: Lilemo tsa bana (ho fihlela lilemo tse 15 - kotsi ea lefu la Reye ho bana ba nang le hyperthermia ka lebaka la mafu a vaerase).

Motsoako Sanovask

Motho ka mong. Bakeng sa batho ba baholo, tekanyetso e le 'ngoe e fapana ho tloha ho 40 mg ho isa ho 1 g, letsatsi le letsatsi - ho tloha ho 150 mg ho isa ho 8 g, khafetsa ea tšebeliso - makhetlo a 2-6 / letsatsi.

Ts'ebeliso ea acetylsalicylic asiti e le moemeli ea thibelang ho ruruha lethal dose ea letsatsi le letsatsi ea 5-8 g e lekanyelitsoe ka lebaka la menyetla e mengata ea litla-morao tse tsoang mpeng ea gastrointestinal.

Pele o buuoa, ho fokotsa ho tsoa mali nakong ea ts'ebetso le nakong ea ts'ebetso, o lokela ho emisa ho nka salicylates ka matsatsi a 5-7.

Nakong ea kalafo ea nako e telele, tlhahlobo ea mali e akaretsang le tlhahlobo ea mali ea mohlolo e lokela ho etsoa.

Ts'ebeliso ea asiti ea acetylsalicylic acid ho bana e hatelloa, hobane maemong a ts'oaetso ea vaerase baneng e tlas'a tšusumetso ea acetylsalicylic acid, menyetla ea ho ba le lefu la Reye e eketseha. Matšoao a lefu la Reye a kenyelletsa ho hlatsa ka nako e telele, ho ruruha haholo ka ho ruruha le ho ruruha ha sebete.

Nako ea kalafo (ntle le ho buisana le ngaka) ha ea lokela ho feta matsatsi a 7 ha e laetsoe e le analgesic le matsatsi a fetang a 3 e le antipyretic.

Nakong ea kalafo, mokuli o lokela ho hana ho noa joala.

Bokhachane le pelehi

Boimana

Tšebeliso ea litekanyetso tse kholo tsa li-salicylates likhoeling tse 3 tse qalang tsa moimana e amahanngoa le khafetsa khafetsa ea bofokoli ba fetal (cleavage ea palate e ka holimo, bofokoli ba pelo). Ho khethoa ha li-salicylate ka har'a trimester ea pele ea boimana ho kopantsoe.

Ka trimester ea bobeli ea kemolo, salicylates e ka fuoa feela ho latela tlhahlobo e tiileng ea kotsi le melemo ho mme le lesea, ka ho khetheha litekong tse sa feteng 150 mg / letsatsi le bakeng sa nako e khuts'oane.

Khoeling ea ho qetela ea kemaro, li-salicylate ka tekanyetso e phahameng (tse fetang 300 mg / ka letsatsi) li baka tšitiso ea pelehi, ho koaloa kapele ha ductus arteriosus ka popelong, ho eketseha ha mali ho 'm'a le lesea, le tsamaiso hanghang pele ho hlaha li ka baka ho ruruha ha methapo pele ho nako. Ho khethoa ha li-salicylate ka har'a trimester ea ho qetela ea moimana ho khahlanong le.

Sebelisa nakong ea lebone

Li-salicylates le li-metabolites tsa tsona ka tekanyo e nyane li fetela lebeseng la matsoele. Ho ja ka mokhoa o sa sebetseng oa li-salicylates nakong ea lebone ho sa tsamaeeng le nts'etsopele ea maikutlo a mabe ka ho ngoana mme ha ho hloke ho felisoa ha letsoele. Leha ho le joalo, ka ts'ebeliso ea nako e telele ea lithethefatsi kapa ho khethoa ha lethal dose le phahameng, ho anyesa ho lokela ho emisoa hanghang.