Aspikor - (Aspikor) litaelo bakeng sa tšebeliso
Moriba o thibela mosebetsi oa enzyme ntle le khethollo cycloo oxygenase 1 le 2 (laola lipalo tsa li-prostaglandins).
Aspicor ea lithethefatsi e na le li-analgesic (analgesia), li-anti-inflammatory le antipyretic.
Motsoako o sebetsang oa acetylsalicylic acid o fokotsa sebopeho sa li-prostaglandins, tlas'a tšusumetso ea hyperalgesia le boikhohomoso. Li-prostaglandins tse fokotsehileng setsing se seholothermoregulation (Haholo-holo E1) e baka ho fufuleloa ho eketsehileng, ho eketsoa ha lumen ea methapo ea mali ea letlalo mme ka lebaka leo, ho fokotseha hoa mocheso oa 'mele.
Phello ea li-analgesic e fihlella ke liketso tsa peripheral le tsa bohareng tsa moriana. Aspicore inhibits synthesis thromboxane A2 liseleng tsa mali tsa mali, ea fokotseha thrombosismekhabiso ea liplatelete le tsa tsona pokello.
Ho bakuli ba nang le mokhoa o sa tsitsang oa angina, acid e sebetsang ea acetylsalicylic acid e ka fokotsa lefu, kotsi ea infyo ea myocardial.
Tšusumetso ea antiplatelet e nka beke ka mor'a ho nka tekanyetso e le 'ngoe.
Tekanyetso ea letsatsi le letsatsi ea ligrama tse 6 kapa ho feta e eketsa nako ea prothrombin, e thibela tlhaho prothrombin liseleng tsa sebete.
Aspicore ea moriana e eketsa khafetsa ha mathata a hemorrhagic nakong ea ts'ebetso ea ho buuoa.
Tlas'a tšusumetso ea lithethefatsi, litlolo li ntlafatsoa uric acid (ka lebaka la tlolo ea tsamaiso ea methapo ea methapo mothong).
Matšoao a ho sebelisoa
Aspicor ea meriana e laetsoe phomolo lefu la bohloko (mefuta e bonolo le e leka-lekaneng) ea tšimolohong e fapaneng: migraine, hlooho e bohloko, myalgiaradicular syndrome algodismenoreaarthralgia lumbago, neuralgia, leino le opang.
Moriana o sebelisetsoa lefu la febrile khahlanong le semelo sa tšoaetso.
Contraindication
Matlapa a aspicor ha a fuoe bakeng sa hemorrhagic diathesis, ka mofuta o mong oa ho mamellana ho acetylsalicylic acid, le asthma ea bronchial, ho tsoa mali ho tsoa mokokotlong oa lijo, ka liso tsa ho ruruha le ho ruruha ha methapo ea methapo, ho ima ka nako e le 'ngoe (li-trimesters tsa pele, tsa boraro), ho anyesa le bana ho fihlela ba le lilemo tse leshome le metso e mehlano.
Litlamorao
Matlapa a Aspicor a ka baka lets'ollo, ho nyekeloa le pelo, likarabelo tsa mefuta eohle ka mokhoa oa angioedema, lekhopho la letlalo le bronchospasm.
Khahlano le semelo sa kalafo, tlolo ea ts'ebetso ea liphio le tsamaiso ea sebete e khonahala Reye's syndrome (sebopeho se potlakileng sa ho hloleha ha sebete, sebete dystrophy le encephalopathy), leukopenia, thrombocytopeniaanemia e matla.
Pheko ea nako e telele e kanna ea tsamaea le hypocoagulationliso tse hlaselang le tse ka kulang tsa tšilo ea lijo, letsoalo, migraine, ho hlatsa, likhathatso tsa pono,bohareng ba jadeho tsoa mali, papillary necrosis, azotemia ea bokhachane le hypercalcemia le hypercreatininemia, ho ruruha, matšoao a ho hloleha ha pelo, meningitis ea aseptic, li-enzyme tsa sebete, nephrotic syndrome.
Aspicor, litaelo tsa tšebeliso (Mokhoa le litekanyetso)
Matlapa a aspicor a nooa ka molomo.
Ka bohloko, lefu la mokokotlo moriana o nooa ka molomo ho isa ho ligrama tse 3 (tekanyetso e khothalelitsoeng ke ligrama tse 0,5-1 ka letsatsi) bakeng sa tekanyetso tse tharo.
Ha e le moemeli oa li-analgesic le anti-inflammatory, Aspicor e laetsoe lethal dose ea 325 mg.
Nako ea kalafo ha ea lokela ho feta libeke tse peli.
Sebopeho sa moriana oa effeedcent se lokela ho qhalwa pele ho 100-200 ml ea metsi. Sekhahla se le seng sa lithethefatsi ke ligrama tse 0,25-1 (makhetlo a 3-4 ka letsatsi).
Bongata
Maemong a matla a ho fetella ka ho feteletseng, hypoglycemia, hyperventilation, komello, feberu, ketoacidosis, pelo le ho hloleha ho hema hoa khoneha.
Ho hlokahala sepetlele ka tšohanyetso, ts'ebeliso ea makala a ts'ebetso ea mashala a ts'ebetso, ts'oaetso ea sefuba, diresis, hemodialysis, le kalafo ea matšoao.
Tšebelisano
Litaelo tsa tšebeliso Aspicore ha e khothaletse tšebeliso ea moriana ka nako e le ngoe le li-agents tsa hypoglycemic, valproic asiti, methotrexate, li-antiplatelet agents, thrombolytics,anticoagulants e sa tobang, heparin, sulfonamides, li-antihypertgency le li-uricosuric agents, diuretics.
Kotsi ea ho tsoa mali ka mpeng e eketseha ka kalafo e ts'oanang ka li-glucocorticosteroids le meriana e nang le ethanol.
Aspikor e khona ho eketsa bongata ba li-barbiturates, digoxin, letsoai la lithium ho plasma.
Ho fufuleloa ha acetylsalicylic acid e fokotseha nakong ea kalafo antacid.
Phello ea hematotoxic ea Aspicore e eketseha ka kalafo ka lithethefatsi tsa myelotoxic.
Litaelo tse khethehileng
Ts'ebeliso ea Aspikor joalo ka lithethefatsi tse thibelang mafu e fokola ka lebaka la kotsi e kholo ea ho ba le NSAIDs-gastropathy.
Nako ea kalafo ha ea lokela ho feta matsatsi a 5.
Hajoale, sethethefatsi ha se laeloe rheumatic choreaMofuta oa mafu a tšoaetsanoang myocarditis, le ramatiki, hammoho le pericarditis le rheumatism.
Aspicor e khothalletsoa hore e hlakoloe matsatsi a 5-7 pele ho ts'ebetso e reriloeng.
Phekolo ea nako e telele e hloka hore ho hlahlojoe lipalo tsa mali, tlhatlhobo ea mantle a mali a moea.
Moriana o khona ho fana ka litlamorao tsa teratogenic.
Acetylsalicylic acid e tšeloa ka lebese la matsoele.
Moriana o ka baka lefu la sethoathoa sa makhopho.
Sebopeho sa ho lokolloa, ho paka le sebopeho Aspicor ®
Matlapa a koahetsoeng a apereng 'mala o mosoeu kapa o batlang o le mosoeu, ho pota, biconvex, karolong ea sefapano - bongata bo boholo bo bosoeu kapa bo batlang bo le bosoeu.
| 1 tab | |
| acetylsalicylic acid | 100 mg |
Bahlomphehi: cellcose ea microcrystalline, lactose monohydrate, sodium ea croscarmellose, silicon dioxide colloidal (aerosil), stearic acid.
Karolo ea ho koahela ho enteric: kopolo ea methaconic acid le ethyl acrylate, propipylene glycol, macrogol 4000, titanium dioxide, talc.
Li-pcs tse 10. - Liphutheloana tsa lithutsoana (1) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.
Li-pcs tse 10. - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa lithutsoana (1) - lipakete tsa karete.
Ketso ea pharmacological
Li-NSAID, moemeli oa antiplatelet. Mochine oa ts'ebetso oa acetylsalicylic acid o ipapisitse le thibelo e ke keng ea fetoloa ea cycloo oxygenase-1 (COX-1), ka lebaka leo ho nang le blockade ea syntomboxane A 2 motsoako le khatello ea pokello ea liplakana. Ho lumeloa hore acetylsalicylic acid e na le mekhoa e meng ea ho hatella ho kopana ha liplatelete, e atolosang boholo ba eona ho mafu a fapaneng a methapo.
Acetylsalicylic acid e boetse e na le anti-inflammatory, analgesic, antipyretic athari.
Mofumahali
Kamora ho tsamaisoa ka molomo, asiti ea acetylsalicylic e ananeloa ho tsoa ka mpeng e nyane e kaholimo. C max ho plasma e bonoa ka karolelano ea lihora tse 3 kamora ho kenella ha moriana.
Acetylsalicylic acid e kopana le metabolism e itseng sebeteng le ho etsoa ha li-metabolites tse sa sebetseng hantle.
E pepesoa ke liphio, tse sa fetoheng le tsa metabolites. T 1 / acetylsalicylic acid e ka ba metsotso e 15, bakeng sa metabolites - lihora tse ka bang 3
Matšoao Aspikor ®
- Thibelo ea infracation ea myocardial e mpe moo ho nang le maemo a kotsi (mohlala, lefu la tsoekere, hyperlipidemia, khatello e phahameng ea mali, botena, ho tsuba, ho tsofala),
- Thibelo ea khafetsa myocardial infarction,
- Angina Khmer
- thibelo ea stroke (ho kenyelletsa le ho bakuli ba nang le lefu la nakoana la mokokotlo),
- Thibelo ea kotsi ea nakoana ea ts'ebetso ea methapo,
- Thibelo ea thromboembolism kamora ho buuoa le ho kenella ka hare ho methapo ea methapo (mohlala, coronary artery bypass grafting, carotid artery endarterectomy, arteriovenous shunting, carotid artery angioplasty),
- thibelo ea "vein thrombosis" e tebileng le "thromboembolism" ea methapo ea methapo le makala a sona (mohlala, ka ho tsitsisa ha nako e telele ka lebaka la ts'ebetso e kholo ea ts'ebetso ea bongaka.
| Khoutu ea ICD-10 | Pontšo |
| G45 | Litlhaselo tsa nakoana tsa nakoana tsa "cecentent" tsa tlhaselo ea ischemic le li-syndromes tse amanang |
| I20.0 | Angina e sa sebetseng |
| I21 | Acal myocardial infarction |
| I26 | Pulmonary embolism |
| I61 | Intracerebral hemorrhage (mofuta oa hemorrhagic oa kotsi ea methapo ea methapo) |
| I63 | Mofuta oa khoheli |
| I74 | Embolism le arterial thrombosis |
| I82 | Embolism le thrombosis ea methapo e meng |
Melemo ea litekanyetso
Matlapa a lokela ho nooa ka molomo, pele ho lijo, ka metsi a mangata.
Thibelo ea infusions e belaetsang ea myocardial: 100-200 mg / ka letsatsi (Letlapa la pele le tlameha ho hlafunoa bakeng sa ho monya kapele).
Thibelo ea infrection ea makhopho a hlobaetsang le a hlobaetsang le a nang le maemo a kotsi: 100 mg / letsatsi.
Thibelo ea infraction ea myocardial e sa khaotseng, angina e sa tsitsang, thibelo ea ho tšoaroa ke lefu la mokokotlo le koluoa ea nakoana, thibelo ea mathata a hlahang ka mor'a ho buuoa kapa lithuto tse hlaselang: 100-300 mg / ka letsatsi.
Ho thibeloa ha methapo e tebileng ea methapo le thromboembolism ea methapo ea methapo ea methapo le makala a eona: 100-200 mg / ka letsatsi.
Setlhare sena se reretsoe tšebeliso ea nako e telele. Nako ea kalafo e khethoa ke ngaka e eang.
Litla-morao
Ho tsoa ho tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, ho opeloa ke pelo, ho hlatsa, bohloko bo ka mpeng, ho ruruha ha liso ka mpeng le ka mpeng ea duodenum (ho kenyelletsoa le ho etsoa ka mokhoa o phethahetseng), mali a tsoang ka mpeng, mosebetsi o eketsehileng oa li-enzyme tsa sebete.
Ho tsoa ts'ebetsong ea phefumoloho: bronchospasm.
Ho tsoa ho tsamaiso ea hemopoietic: ho tsoa mali ho eketsehileng, ka seoelo - khaello ea mali.
Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: ho tsekela, tinnitus.
Litlamorao: urticaria, edema ea Quincke, maikutlo a anaphylactic.
Bokhachane le pelehi
Ts'ebeliso ea li-salicylates ka tekanyetso e phahameng ho trimester ea pele ea kemaro e amahanngoa le khafetsa khafetsa ea bofokoli ba nts'etsopele ea fetal (karohano e arohaneng, likotsi tsa pelo). Ka trimester ea bobeli ea boimana, li-salicylates li ka fuoa feela ka tlhahlobo e tiileng ea kotsi le molemo.
Karolong ea boraro ea kemolo, li-salicylate tse noang haholo (tse fetang 300 mg / letsatsi) li baka tšitiso ea pelehi, ho koaloa kapele ha ductus arteriosus ka popelong, ho eketseha ha mali ho 'm'a le lesea, le tsamaiso hanghang pele ho hlaha li ka baka hemorrhage e kenang pele ho nako. Ho khethoa ha li-salicylate ka har'a trimester ea III ea bokhachane ho khahlanong le.
Li-salicylates le li-metabolites tsa tsona ka bongata bo nyane li pepesoa lebeseng la matsoele. Ho ja ka mokhoa o sa sebetseng oa li-salicylates nakong ea lebone ho sa tsamaeeng le nts'etsopele ea maikutlo a mabe ka ho ngoana mme ha ho hloke ho felisoa ha letsoele. Leha ho le joalo, haeba u hloka tšebeliso ea lithethefatsi ka nako e telele kapa ho beoa ka tekanyetso e phahameng, letsoele le lokela ho emisoa hanghang.
Ho sebelisana le lithethefatsi
Ka tšebeliso e tšoanang ea acetylsalicylic acid e ntlafatsa ketso ea litlhare tse latelang:
- methotrexate ka ho fokotsa tumello ea ho hlaba le ho e tlosa ho tsoa puisanong le liprotheine,
- heparin le anticoagulants e sa tobang ka lebaka la ts'ebetso ea liplatelese e sa sebetseng le ho fallisoa ha li-anticoagulants tse sa tobang ho tsoa puisanong le liprotheine,
- thrombolytic le antiplatelet lithethefatsi (ticlopidine),
- digoxin ka lebaka la ho fokotseha ha popo ea eona ea renal,
- hypoglycemic agents (insulin le sulfonylurea derivatives) ka lebaka la thepa ea hypoglycemic ea acetylsalicylic acid ka boeona e le tekanyetso e phahameng le ho tlosoa ha liphihlelo tsa sulfonylurea puisanong le liprotheine,
- valproic acid ka lebaka la ho falla ho eona ho tsoa puisanong le liprotheine.
Phello ea tlatsetso e bonoa ha u ntse u nka acetylsalicylic acid ka ethanol.
Acetylsalicylic acid e nyenyefatsa phello ea lithethefatsi tsa uricosuric (benzbromarone) ka lebaka la ho felisoa ha tubular ea uric acid.
Ka ho ntlafatsa ho felisoa ha li-salicylates, li-corticosteroids tsa systemic li fokolisa matla a tsona.
VERTEX AO (Russia)
199106 St. Petersburg Aspikard (BORISOVA MOLEMO WA LITLHAKU TSA BOPHELO, Rephaboliking ea Belarus) Aspinat ® (VALENTA PHARMACEUTICS, Russia) Aspinat ® Cardio (VALENTA PHARMACEUTICS, Russia) Aspirin ® Cardio (BAYER CONSUMER CARE, Switzerland) Acetylcardio-LekT (TYUMEN CHEMICAL - TLHALOSO EA MOTSOALLE, Russia) Sokolla foromo le sebopehoAspicore e hlahisoa ka mokhoa oa matlapa a koahetsoeng ka enteric: hoo e ka bang e tšoeu kapa e tšoeu, biconvex, ho potoloha, karolong ea sefapano - bongata bo boholo ba hoo e ka bang bosoeu kapa bosoeu (li-pcs tse 10. Ka lipaketeng tsa blister, ka lebokoseng la karete ea 1, 2, 3 kapa 3 Lipakete tse 6, likhomphutha tse 15. E 'ngoe le e' ngoe e na le liphutheloana tsa lithutsoana, ka har'a pakete ea 2 kapa 4, likarete tse 20. Liphuthelong tse nang le lithupa, ka lebokoseng la 1 kapa 3, lipakete tse 30. ) Letlapa la 1
Tekanyetso le tsamaisoAspikor e nooa ka molomo, pele ho lijo, matlapa a lokela ho hlatsuoa ka metsi a mangata. Setlhare se etselitsoe tšebeliso ea nako e telele, thupelo e beoa ka bo eona ke ngaka e eang. Ha kalafo ea angina e sa tsitsang, Aspicor sebelisa matlapa a 1-3 (100-300 mg) ka letsatsi. Bakeng sa ho thibela lithethefatsi ho khothalletsoa ho nooa ka tekanyetso e latelang ea letsatsi le letsatsi:
Aspicore, litaelo tsa tšebeliso: mokhoa le litekanyetsoMatlapa a aspicore a tlameha ho nooa ka molomo pele ho lijo, ka maro a mangata. Litekanyetso tse khothalelitsoeng letsatsi le letsatsi
Aspikor e etselitsoe pheko ea nako e telele, nako ea eona e khethiloeng ke ngaka e eang. Bokhachane le pelehi
Aspicore: litheko tsa litlhare tsa marang-rangAspicore 100 mg, litafole tse koahetsoeng ka ente ea 100 mg. ASPICOR 100mg 30 li-pcs. matlapa a koahetsoeng a kopantsoeng Sebaka sa Aspicor. .p / o filimi. enteric. 100mg n30 ASPICOR 100mg 90 li-pcs. matlapa a koahetsoeng a kopantsoeng Sebaka sa Aspicor. n / a ksh / sol. 100mg No. 90 Aspicore 100 mg, litafole tse koahetsoeng ka ente ea 90 mg.
Thuto: Univesithi ea bongaka ea pele ea bongaka ea Moscow State e reheletsoeng ka I.M. Sechenov, ngaka e ikhethang "General Medicine". Tlhahisoleseling mabapi le sethethefatsi e akaretsoa ka kakaretso, e fanoa molemong oa tlhahisoleseling mme ha e nke sebaka sa litaelo tsa semmuso. Ho ikoetlisa ho kotsi bophelong! Mosebetsi oo motho a sa o rateng o kotsi haholo ho psyche ea hae ho feta ho hloka mosebetsi ho hang. Ho latela liphuputso, basali ba noang likhalase tse 'maloa tsa biri kapa veine ka beke ba na le menyetla e eketsehileng ea ho tšoaroa ke mofetše. Moahi oa Australia ea lilemo li 74 ea bitsoang James Harrison o ile a fana ka mali makhetlo a ka bang sekete. O na le mofuta oa mali o sa tloaelehang, li-antibodies tsa ona tse thusang masea a sa tsoa tsoaloa a nang le anemia e matla hore a phele. Kahoo, Australia e ile ea pholosa bana ba ka bang limilione tse peli. Ho ea ka bo-rasaense ba bangata, li-vithamine complexes ha li na thuso ho batho. Ha re ntse re nyenyefatsa, 'mele oa rona o khaotsa ho sebetsa ka botlalo. Leha pelo e emisa. Nakong ea bophelo, motho ea tloaelehileng ha a hlahise matamo a maholo a ka tlase ho a mabeli. E ne e le tloaelo eo e ruisa 'mele le oksijene. Leha ho le joalo, pono ena e ile ea hlakoloa. Bo-rasaense ba pakile hore ho hahola, motho ho folisa kelello le ho ntlafatsa ts'ebetso ea eona. Nakong ea ts'ebetso, boko ba rona bo sebelisa matla a lekanang le bulb ea khanya ea li-watt tse 10. Kahoo setšoantšo sa bulb e bobebe ka holim'a hlooho ea hau ka nako ea ponahalo ea mohopolo o khahlisang ha se hole haholo le 'nete. Haeba u oa ho tsoa ho esele, ho na le menyetla e mengata ea hore o tla kokota molala ho feta haeba o oa ho tloha ho pere. Feela u se ke ua leka ho hanyetsa polelo ena. E le ho leka ho ntša mokuli, lingaka hangata li fetella. Kahoo, ka mohlala, Charles Jensen ea itseng ka nako ea ho tloha 1954 ho fihlela 1994. e pholohile tšebetso e fetang 900 ea ho tlosa neoplasm. Motho ea nkang khatello ea maikutlo maemong a mangata o tla boela a be le khatello ea maikutlo. Haeba motho a sebetsana le khatello ea maikutlo a le mong, o na le monyetla o mong le o mong oa ho lebala ka boemo bona ka ho sa feleng. Le ha pelo ea motho e sa otla, o ntse a ka phela nako e telele, joalo ka motšoasi oa litlhapi oa Norway Jan Revsdal. “Enjene” ea hae e ile ea emisa lihora tse 4 ka mor'a hore motšoasi oa litlhapi a lahlehe ebe o robala lehloa. Qalong lithethefatsi tse ngata li ne li rekisoa ka lithethefatsi. Ka mohlala, qalong heroin e ile ea rekisoa e le moriana oa khohlela. Mme cocaine e ile ea khothalletsoa ke lingaka e le mokhoa oa ho ikoetlisa le mokhoa oa ho eketsa mamello. Mocheso o phahameng ka ho fetisisa oa 'mele o tlalehiloe ho Willie Jones (USA), ea ileng a kenngoa sepetlele ka mocheso oa 46,5 ° C. Sebete ke setho se boima haholo 'meleng oa rona. Boima ba hae bo itekanetseng ke 1.5 kg. Oli ea tlhapi e 'nile ea tsejoa ka mashome a lilemo,' me ka nako ena ho netefalitsoe hore e thusa ho imolla ho ruruha, ho imolla bohloko bo kopaneng, ho ntlafatsa sos.
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