Mokhoa oa ho bala litekanyetso tsa Amoxiclav 125, 250, 375 le 400 mg ho bana: litaelo tsa ts'ebeliso ea ho emisoa le matlapa
Amoxiclav ® ke motsoako oa amoicillin - semisynthetic penicillin e nang le mefuta e mengata ea mesebetsi ea antibacterial le clavulanic acid - inhibitor e ke keng ea fetoloa ea β-lactamases. Clavulanic acid e etsa motsoako o sa tsitsang ka li-enzyme tsena mme e tiisa ho hanyetsoa ha amoxicillin litlamorao tsa β-lactamases tse hlahisoang ke likokoana-hloko.
Clavulanic acid, e tšoanang ka sebopeho sa lithibela-mafu tsa beta-lactam, e na le ts'ebetso e fokolang ea antibacterial.
Amoxiclav ® e na le bongata bo bongata ba ketso ea antibacterial.
E sebetsang khahlanong le Mefuta e amehang ea Amoxicillin, ho kenyelletsa le β-lactamase e hlahisang mefuta, ho kenyeletsa libaktheria tse matla tsa aerobic: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (ntle le molemong oa methapo ea methapo e thibelang methapo), Staphylococcus epidermidis (ntle le likhakanyo tse thibelang methicillin), Staphylococcus saprophyo libaktheria tse mpe tsa aerobic: Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Moraxella catarrhalis, Pippis neisseria gonorrhoeae Somppella meppida meppida mepprea Vibrio k'holera, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens, baktheria e ntle ea gram: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., gram-negative anaerobes: Bacteroides spp.
Mofumahali
Litekanyetso tse ka sehloohong tsa pharmacokinetic ea amoxicillin le clavulanic acid lia tšoana.
Likarolo tsena ka bobeli li ananeloa hantle kamora ho sebelisa moriana kahare, ho ja ha ho ame boemo ba ho monya. Cmax plasma ea mali e fihlella hora e le 'ngoe ka mor'a ts'ebetso. C bolengmax etsa bakeng sa amoxicillin (ho latela tekanyetso) 3-12 μg / ml, bakeng sa acid ea clavulanic - hoo e ka bang 2 μg / ml.
Likarolo tsena ka bobeli li tšoauoa ka bophahamo bo boholo ba karolelano maro a 'mele le liseleng (matšoafo, tsebe e bohareng, mokelikeli oa methapo ea methapo le methapo ea popelo, popelo, mahe a linotsi, jj.). Amoxicillin e boetse e kenella mokelikeli oa mokokotlo, sebete, tšoelesa ea senya, masapo a mokokotlo, lesapo la mokokotlo, lesapo la nyooko, secretion ea sinuse, mathe, sephiri sa bronchial.
Amoxicillin le clavulanic acid ha e kenelle BBB ka litheipi tse sa koaeloang.
Amoxicillin le clavulanic acid li haola le tšitiso ea placental 'me ka bongata li fumaneha ka lebese la matsoele. Amoxicillin le clavulanic acid li tsebahala ka ho tlama liprotheine tsa plasma haholo.
Amoxicillin e na le metabolite e itseng, 'nete ea hore clavulanic acid e ka tlas'a metabolism e matla.
Amoxicillin e hloekisoa ke liphio hoo e batlang e sa fetoloe ke secretion ea tubular le filtration ea glomerular. Clavulanic acid e hloekisoa ka ho fafatsa glomerular, ka karolo e 'ngoe e le metabolites. Lintho tse nyane li ka fokotsoa ka mala le matšoafo. T1/2 amoxicillin le clavulanic acid ke lihora tse 1-1,5
Pharmacokinetics maemong a khethehileng a kliniki
Ho hlohlona ho matla ha renal1/2 e nyolohela ho lihora tse 7.5 bakeng sa amoxicillin le lihora tse 4,5 bakeng sa clavulanic acid. Likarolo tsena ka bobeli li tlosoa ke hemodialysis le likhahla tse nyane ka peritoneal dialysis.
Tšoaetso e bakoang ke mefuta e meholo ea likokoana-hloko:
- tšoaetso ea phepelo ea ka holimo ea phefumoloho le litho tsa ENT (ho kenyelletsa sinusitis e mpe le e sa foleng, mecha ea litaba e hlobaetsang le e sa foleng, lefu la sethoathoa la sethoathoa, "tonsillitis, pharyngitis"
- Ts'oaetso ea ts'ebetso e tlase ea ho hema (ho kenyelletsa le bronchitis e mpe e nang le tšoaetso ea baktheria, bronchitis e sa foleng, pneumonia),
Tšoaetso ea pampitšana ea urinary
- ts'oaetso ea letlalo le lisele tse bonolo, ho kenyelletsa ho loma ha liphoofolo le batho,
- tšoaetso ea lithapo tse amanang le masapo le
- le tšoaetso ea pampitšana ea biliary (cholecystitis, cholangitis),
Contraindication
- Hypersensitivity ho efe kapa efe ea likarolo tsa moriana,
- Hypersensitivity historing ho penicillin, cephalosporins le lithibela-mafu tse ling tsa beta-lactam,
- nalane ea mats'oao a kankere ea cholestatic le / kapa ts'ebetso e 'ngoe e holofetseng ea sebete e bakoang ke tsamaiso ea amoxicillin / clavulanic acid,
- Lefu la ho tšoaetsoa mononucleosis le leukemia ea tšoaetso.
Le tlhokomeliso lithethefatsi li lokela ho sebelisoa le nalane ea pseudomembranous colitis, ka ho se sebetse hantle ha sebete, ho senyeha ho matla ha renal, hammoho le nakong ea ho beleha.
Litlamorao
Litla-morao tse ngata li bobebe ebile lia lieha.
Ho tsoa ts'ebetsong ea tšilo ea lijo: ho felloa ke takatso ea lijo, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, bohloko bo ka mpeng, ho senyeha hoa ts'ebetso ea sebete, ts'ebetso e eketsehileng ea li-enzyme tsa sebete (ALT kapa AST), maemong a ikhethileng - cholestatic jaundice, hepatitis, pseudomembranous colitis.
Litla-morao: pruritus, urticaria, erythematous rash, hangata - limtiforme exudative erythema, angioedema, anaphylactic shock, allergic vasculitis, maemong a sa tloaelehang - exfoliative dermatitis, Stevens-Johnson syndrome, a hlobaetsang le pustulosis e matla.
Ho tsoa ho sheropoietic system le li-lymphatic system: ka seoelo - leukopenia e khutlisetsoang (ho kenyelletsa le neutropenia), thrombocytopenia, ka seoelo - hemolytic anemia, keketseho e khutlang ea nako ea prothrombin (ha e kopantsoe le anticoagulants), eosinophilia, pancytopenia.
Ho tsoa tsamaisong ea methapo: ho tsekela, ho opeloa ke hlooho, ka seoelo - ho tšoha (ho ka etsahala ho bakuli ba nang le bothata ba ho sebetsa ha renal ha ba sebelisa moriana o tekanyetso e phahameng), khatello ea maikutlo, ho tšoenyeha, ho hlobaela.
Ho tsoa ts'ebetsong ea moroto: ka seoelo - interstitial nephritis, crystalluria.
Tse ling: ka seoelo - nts'etsopele ea superinfection (ho kenyeletsa le candidiasis).
Bongata
Ha ho na litlaleho tsa lefu kapa litlamorao tse behang bophelo kotsing ka lebaka la lithethefatsi tse ngata.
Matšoao Maemong a mangata, ho ba le mathata a methapo ea ka mpeng (mahlaba a ka mpeng, lets'ollo, ho hlatsa), ho tšoenyeha, ho hloka boroko, ho tsekela, le maemong a ikhethileng a ho tsietsana.
Phekolo: mokuli o lokela ho ba tlas'a tlhokomelo ea bongaka, kalafo ea matšoao. Tabeng ea tsamaiso ea morao-rao ea lithethefatsi (nako e ka tlase ho lihora tse 4), ho hlokahala hore ho hlatsuoe mpa le ho fana ka litlolo tse entsoeng ka mashala ho fokotsa ho amoheloa ha moriana. Amoxicillin / potasiamo clavunate e tlosoa ke hemodialysis.
Litaelo tse khethehileng
Ka mokhoa oa kalafo, ts'ebetso ea mali, sebete le liphio li lokela ho hlahlojoa.
Bakeng sa bakuli ba nang le ts'ebetso e matla ea renal e sa sebetseng hantle, ho hlokahala tokiso e lekaneng ea mofuta oa dosing kapa ho eketsa sekhahla pakeng tsa dosing.
Bakeng sa ho fokotsa kotsi ea karabelo e mpe e tsoang mpeng ea gastrointestinal, moriana o lokela ho nooa le lijo.
Liteko tsa laboratori: Litekanyetso tse phahameng tsa amoxicillin li fana ka karabelo e fosahetseng ea tsoekere ea moroto ha u sebelisa tharollo ea Benedict kapa tharollo ea Felling. Ho khothaletsa maikutlo a Enzymatic ka glucosidase.
Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo
Ha ho na data ka phello e mpe ea Amoxiclav ho litekanyetso tse khothalletsoang mabapi le bokhoni ba ho khanna koloi kapa ho sebetsa ka mekhoa.
Ho sebelisana le lithethefatsi
Ka tšebeliso e tšoanang ea lithethefatsi Amoxiclav ® e nang le li-antacids, glucosamine, laxatives, aminoglycosides, ho amoheloa hoa lebelo ho theoha, ka ascorbic acid - ea eketseha.
Diuretics, allopurinol, phenylbutazone, NSAIDs le lithethefatsi tse ling tse thibelang secretion ea tubular li eketsa khatello ea amoxicillin (clavulanic acid e hlahisoa haholo-holo ke fomete ea glomerular).
Ka tšebeliso ea nako e tšoanang ea Amoxiclav ® e eketsa chefo ea methotrexate.
Ka tšebeliso e tšoanang ea Amoxiclav le allopurinol, monyetla oa exanthema o eketseha.
Tsamaiso e kopanetsoeng e nang le disulfiram e lokela ho qojoa.
Maemong a mang, ho sebelisa lithethefatsi ho ka lelefatsa nako ea prothrombin, ntlheng ena, tlhokomeliso e lokela ho sebelisoa ha ho ntse ho fanoa ka li-anticoagulants le lithethefatsi Amoxiclav ®.
Motsoako oa amoxicillin le rifampicin ke mohanyetsi (ho na le ho fokotsoa hoa matla a antibacterial).
Amoxiclav ® ha ea lokela ho sebelisoa ka nako e le ngoe le lithibela-mafu tsa bacteriostatic (macrolides, tetracyclines), sulfonamides ka lebaka la phokotseho e ka bang teng ts'ebetsong ea Amoxiclav.
Probenecid e fokotsa tlhahiso ea amoxicillin, e eketsa khatello ea eona ea serum.
Lithethefatsi li fokotsa katleho ea lithibela-pelehi tsa molomo.
Mokhoa oa kopo
Litekanyetso tsa letsatsi le letsatsi tsa ho emisoa ka makhetlo a 500 mg + 31.25 mg / 5 ml le 250 mg + 62,5 mg / 5 ml (ho tsamaisa dosing e loketseng ea ho emisoa ha li-75 mg + 31.25 mg / 5 ml le 250 mg + 62,5 mg / 5 ml ea ho emisoa sephuthelong se seng le se seng, khaba ea litekanyetso e nang le bokhoni ba 5 ml kapa pipette ea litekanyetso tsa moralo e kentsoe).
Bana ba sa tsoa tsoaloa le bana ho isa ho likhoeli tse 3 khetha 30 mg / kg (amooticillin) / letsatsi, e arotsoe ka litekanyetso tse peli (lihora tse ling le tse ling tse 12), bana ba fetang likhoeli tse 3 - ho tloha ho 20 mg (amoxicillin) / kg / letsatsi ho tšoaetsobonolo ho tekano e tebileng ho fihla ho 40 mg / kg (ho ea ka amooticillin) / letsatsi ho tšoaetso e matla le tšoaetso ea phepelo ea phefumoloho arotsoe ka litekanyetso tse 3 (lihora tse ling le tse ling tse 8).
Tekanyetso e khothalelitsoeng ea ho emisoa ho latela boima ba 'mele ba ngoana le ho teba ha tšoaetso.
| Boima ba 'mele (kg) | Age (hoo e ka bang) | Matšoao a tšoaetsanoang ke lung / tekano | Tšoaetso e matla | ||
| 125 mg + 31.25 mg / 5 ml | 250 mg + 62,5 mg / 5 ml | 125 mg + 31.25 mg / 5 ml | 250 mg + 62,5 mg / 5 ml | ||
| 5-10 | 3 likhoeli tse | 3 × 2,5ml (1 /2 l.) | 3 × 1.25 ml (1 /4 l.) | 3 × 3.75 ml (3 /4 l.) | 3 × 2 ml (1 /4- 1 /2 l.) |
| 10-12 | Lilemo tse 1-2 | 3 × 3.75 ml (3 /4 l.) | 3 × 2 ml (1 /4- 1 /2 l.) | 3 × 6.25 ml (1 1 /4 l.) | 3 × 3 ml (1 /2- 3 /4 l.) |
| 12-15 | Lilemo tse 2-4 | 3 × 5 ml (1 l.) | 3 × 2,5ml (1 /2 l). | 3 × 7.5 ml (1 1 /2 l.) | 3 × 3.75 ml (3 /4 l.) |
| 15-20 | Lilemo tse 4-6 | 3 × 6.25 ml (1 1 /4 l.) | 3 × 3 ml (1 /2- 3 /4 l.) | 3 × 9.5 ml (1 3 /4-2 l.) | 3 × 5 ml (1 l.) |
| 20-30 | Lilemo tse 6-10 | 3 × 8.75 ml (1 3 /4 l.) | 3 × 4,5ml (3 /4-1 l.) | - | 3 × 7 ml (1 1 /4-1 1 /2 l.) |
| 30-40 | Lilemo tse 10-12 | - | 3 × 6.5 ml (1 1 /4 l.) | - | 3 × 9.5 ml (1 3 /4-2 l.) |
| ≥ 40 | ≥ lilemo tse 12 | Amoxiclav ® e behiloe matlapeng | |||
Litekanyetso tsa letsatsi le letsatsi tsa ho emisoa 400 mg + 57 mg / 5 ml li baloa ka kilo e le 'ngoe ea boima ba' mele ho latela boima ba ts'oaetso mme li 25-255 mg / kg boima ba 'mele / letsatsi (ho latela amoxicillin), li arotsoe ka litekanyetso tse peli.
Ho tsamaisa dosing e nepahetseng, ho emisoa ka 400 mg + 57 mg / 5 ml ka har'a sephutheloana se seng le se seng sa litekanyetso tsa litekanyetso, se qetile ka nako e le ngoe ho likarolo tse 1, 2, 3, 4, 5 ml le 4 tse lekanang.
Tekanyetso e khothalelitsoeng ea ho emisoa ho latela boima ba 'mele ba ngoana le ho teba ha tšoaetso.
| Boima ba 'mele (kg) | Age (hoo e ka bang) | Tšoaetso e matla | Tšoaetso e leka-lekaneng |
| 5-10 | 3 likhoeli tse | 2 × 2,5ml (1 /2 lipeipi) | 2 × 1.25 ml (1 /4 lipeipi) |
| 10-15 | Lilemo tse 1-2 | 2 × 3.75 ml (3 /4 lipeipi) | 2 × 2,5ml (1 /2 lipeipi) |
| 15-20 | Lilemo tse 2-4 | 2 × 5 ml (1 pipette) | 2 × 3.75 ml (3 /4 lipeipi) |
| 20-30 | Lilemo tse 4-6 | 2 × 7.5 ml (1 1 /2 lipeipi) | 2 × 5 ml (1 pipette) |
| 30-40 | Lilemo tse 6-10 | 2 × 10 ml (liphaephe tse 2) | 2 × 6.5 ml (1 1 /4 lipeipi) |
Litekanyetso tse nepahetseng tsa letsatsi le letsatsi li baloa ho latela boima ba 'mele ba ngoana, eseng lilemo tsa hae.
Tekanyo e phahameng ea letsatsi le letsatsi ea amoxicillin ke ea tsa batho ba baholo 6 g bakeng sa bana - 45 mg / kg boima ba mmele.
Tekanyo e phahameng ea letsatsi le letsatsi ea clavulanic acid (ka mokhoa oa letsoai la potasiamo) ke ea tsa batho ba baholo 600 mg bakeng sa bana - 10 mg / kg boima ba mmele.
Ho bakuli ba nang le bothata bo matla ba ho phekola ba masapo (CC) ka tlase ho 10 ml / min) tekanyetso e lokela ho fokotsoa ka ho lekana kapa nako ea lipakeng tsa litekanyetso tse peli e lokela ho eketsoa (ka anuria ho fihlela lihora tse 48 kapa ho feta).
Nako ea kalafo ke matsatsi a 5-14. Nako ea kalafo e khethoa ke ngaka e eang. Phekolo ha ea lokela ho lula matsatsi a fetang 14 ntle le tlhahlobo ea bobeli ea bongaka.
Melao ea ho lokisa ho emisoa
Powder bakeng sa ho hlophisoa ha ho emisoa ha 125 mg + 31.25 mg / 5 ml: sisinya botlolo ka matla, eketsa 86 ml ea metsi (letšoao) ka litekanyetso tse peli, nako le nako o sisinyeha hantle ho fihlela phofo e felisoa ka botlalo.
Phofo bakeng sa ho hlophisoa ha ho emisoa ha 250 mg + 62,5 mg / 5 ml: tsukutla botlolo ka matla, eketsa 85 ml ea metsi (ho fihlela letšoao) ka litekanyetso tse peli, nako le nako o sisinyeha hantle ho fihlela phofo e felisoa ka botlalo.
Phofo bakeng sa ho hlophisoa ha ho emisoa ha 400 mg + 57 mg / 5 ml: sisinya botlolo ka matla, eketsa metsi ka bongata bo bontšitsoeng letlalong mme o bonts'oa tafoleng (ho ea ho letšoao) ka litekanyetso tse peli, nako le nako o sisinyeha hantle ho fihlela phofo e felisitsoe ka botlalo.
| Boholo ba boholo | Palo e hlokahalang ea metsi |
| 35 ml | 29,5 ml |
| 50 di ml | 42 ml |
| 70 ml | 59 ml |
| 140 ml | 118 ml |
Pele o sebelisa, ts'oara Vial ka matla.
Amoxiclav: sebopeho le lipontšo tsa ts'ebeliso
Amoxiclav ke lithibela-mafu tse kopaneng tse ka nooang ho phekola maloetse a fapaneng, ho qala ka lefu la bronchitis le ho fela ka mathata a meno. Likarolo tse sebetsang tsa lithethefatsi ke:
Likarolo tse thusang tsa Amoxiclav li kenyeletsa:
- Na citrate
- citric acid
- xanthan gum,
- Na benzoate,
- colloidal silicon dioxide,
- carmellose Na,
- Na saccharin,
- ho natefisa (ciliegia, fragola, lemone),
- mannitol.
Lithibela-mafu li fanoa feela haeba sesosa sa lefu lena e le baktheria e kotsi. Amoxiclav bakeng sa bana le batho ba baholo e laetsoe ts'oaetso ea ts'oaetso ea phepelo e phahameng le e tlase ea ho hema le litho tsa ENT. Mekhoa e joalo ea ts'oaetso e kenyelletsa:
- tonsillitis (tonsillitis),
- sinusitis e mpe kapa e sa foleng,
- atitis otitis media
- pharyngitis
- pyelonephritis,
- pharyngeal abscess,
- sinusitis
- bronchitis
- pneumonia
Ts'ebeliso ea moriana o thibelang likokoana-hloko oa hlokahala mabapi le:
Mokhoa oa ho lokolla: ho emisoa le matlapa
Indasteri ea meriana e fa moreki mefuta e 'meli ea ho lokolloa ha moriana o thibelang likokoana-hloko. Ea pele ke lipilisi. E loketse baholo. Monyetla o moholo oa foromo ena ke hore ho bonolo ho sebelisa litafole kae kapa kae, o shebile mofuta oa tsamaiso. Li fumaneha ka tekanyetso ea 250 le 500 mg ea amoxicillin le 125 mg ea clavulanic acid. Ka blister - matlapa a 15 kapa a 20.
Mofuta oa bobeli oa tokollo ke phofo eo ho emisoa ho eona ho lokisitsoeng. Ho molemo hore ngoana a fumane amoxiclav ka foromo ena, haholo-holo ho ba sa tsebeng ho hlafuna kapa ho metsa matlapa.
Tafole e ka tlase e bonts'a litekanyetso tseo ho hlahisoang phofo ea Amoxiclav bakeng sa bana:
| The lethamo lohle ka ho 5 ml ya ho emisoa, mg | Motsoako oa amoxicillin, mg | Motsoako oa clavulanic acid, mg |
| 125 | 125 | 31,25 |
| 250 | 250 | 62,5 |
| 400 | 400 | 57 |
Phofo le ho emisoa ho lokisitsoeng li tšoeu kapa li bosoeu bo bosehla. Sehlahisoa se fumaneha ka lijaneng tsa khalase tse lefifi tse nang le molumo oa 100 ml. Ka botlolong ea ligrama tse 25 tsa phofo. Sephutheloana sena se na le khaba kapa polasetara e lekanyang. Mokhoa oa ho hlophisa ho emisoa, o ka bala litaelo tse kentsoeng mme oa shebella video bakeng sa sengoloa ka algorithm ea methati.
U ka lekanya litekanyetso tsa moriana joang?
Ho fumana sephetho se potlakileng sa ho nka moriana o thibelang likokoana-hloko le ho fokotsa monyetla oa litla-morao, ho hlokahala hore u tsebe tekanyetso ea lithethefatsi mme u hlapolle ka nepo mme u fe ngoana sirapo kapa matlapa hore a noe.
Ho etsa lipalo tse nepahetseng tsa tšebeletso e le 'ngoe ea Amoxiclav, lintlha tse latelang li lokela ho nahanoa:
- lilemo tsa ngoana
- boima ba mokuli e monyane
- lefu le itseng
- boteng ba lefu lena.
Bakeng sa bana ba ho tloha likhoeli tse hlano ho isa ho lilemo tse leshome ka tekanyo e matla ea nako ea ts'oaetso, ho lekane ho hlapolla phofo ka litekanyetso tsa 125 mg. Haeba angina, pneumonia kapa pathology e 'ngoe e thata, joale pheko e fanoa ka ntho e sebetsang ea antibacterial ka bongata ba 250 kapa 400 mg.
Ho emisoa - bakeng sa bana ba ka tlase ho lilemo tse leshome le metso e 'meli
Ha o sebelisa foromo ea phofo, mohato oa pele ke ho lokisa ho emisoa. Ho etsa sena, tšela phofo ka metsi ka botlolong ho menyetla e teng holim'a khalase ea eona. Metsi a lokela ho belisoa le ho koaheloa. Kamora motsoako o tlameha ho sisinngoa, e le hore o tsoakoe.Ho emisoa ho lokisitsoeng ho ka bolokoa nako e sa feteng beke sehatsetsing.
Sebelisa khaba kapa seratsoana sa metha, lekanya palo ea sirapo e hlokahalang. Ke bokae bo hlokahalang ho fa ngoana sirapo ho fihlela selemo kapa ngoana ea moholo a ka fumanoa litaelong tsa ts'ebeliso. E na le litafole mme e hlalosa mokhoa oa ho li sebelisa ho bala palo e nepahetseng ea lithethefatsi. Ha u fana ka moriana o thibelang likokoana-hloko, ngaka e lokela ho bontša tekanyetso ea nyeoe e itseng, ho latela lilemo le lefu, hape le ho bolela hore na ke matsatsi a makae a lokelang ho nooa antibacterial.
Haeba ngoana a e-so be le likhoeli tse 3, joale litekanyetso tsa letsatsi le letsatsi ke 30 mg ka kilo e le ngoe ea boima ba 'mele. Moriana o nooa o mong le o mong lihora tse 12. Kamora likhoeli tse 3, lethal dose ke 20 mg ka kilogramu, empa moriana o fuoa lihora tse ling le tse ling tse 8. Sena ke ka lefu le bonolo kapa le leka-lekaneng. Maemong a matla, e nyolohela ho 40 mg / kg ka nako e ts'oanang.
Bakeng sa bonolo, tse latelang ke litekanyetso tsa ho emisoa Amoxiclav bakeng sa lilemo tse fapaneng ka li-tee:
| Lilemo tsa ngoana | Motsoako, likhaba | Palo ea likamohelo ka letsatsi |
| 3 likhoeli tse | 1/2 | 3 |
| Lilemo tse 1-7 | 1 | 3 |
| Lilemo tse 7-14 | 2 | 3 |
Matlapeng - a bana ba baholoanyane
Foromo ea Letlapa la antioxacterial drug Amoxiclav e etselitsoe batho ba baholo le bana ba ka holimo ho lilemo tse 12-14. Letlapa le le leng le na le 375 mg ea motsoako o sebetsang. Li nooa hararo ka letsatsi, letlapa le le leng.
Tekanyo e fapana ho latela boemo. Ka angina, bana ba fuoa tafole e nang le karohano ea lihora tse 8, ka lefu le leng - lihora tse ling le tse ling tse 12. Maemong a tebileng, ngaka e eang e ka eketsa tekanyetso e le 'ngoe ho fumana phello e potlakileng.
U ka fa bana ba lilemo tse fapaneng joang?
Ho sa tsotelehe lilemo tsa mokuli, ho na le melao ea hore na u ka nka Amoxiclav joang:
- Rea amohela ka lijo. Haeba u noella moriana oa lijo ka lijo, sena se fokotsa haholo menyetla ea litla-morao tsa ka mpeng.
- Litokisetso tsa ho emisoa pele u li sebelisa.
- Ho beha leihlo boemo ba lesea. Ho bohlokoa ho hlokomela ka hloko liphetoho tsohle maemong le maikutlong a mokuli e monyane, a matle le a fosahetseng. Ka lipontšo tse mpe, o lokela ho emisa ho sebelisa moriana o il'o buisana le setsebi.
- Se ke oa kena-kenana le thuto. Tšusumetso e lula kamora hore kalafo e phetheloe ka botlalo.
- Boloka letsatsi la ho felloa ke nako. O lilemo li 2. Ho emisoa ho felisitsoeng ho bolokiloe sehatsetsing matsatsi a sa feteng a 7.
- Latela tekanyetso e behiloeng.
- Laola boemo ba liphio, tsamaiso ea lesapo le ho potoloha ha mali.
Ka bonolo ho isa ho bokuli bo itekanetseng
Palo ea moriana o laetsoeng maemong a mangata ha e supe lilemo tsa mokuli, empa boima ba 'mele oa hae, hobane bana bohle ba fapane, le boima ba bona ka lilemo tse ts'oanang bo ka fapana haholo. Leha ho le joalo, boteng ba lefu lena le bapala karolo ea bohlokoa ka ho tšoanang kalafong ea lithibela-mafu.
Ha e le mefuta ea lefu lena le bonolo le le leka-lekaneng, joale mokhoa o tloaelehileng oa sebetsa. Ho emisoa ha 125 kapa 250 ml ho fanoe ka makhetlo a mararo ka letsatsi. Hoa hlokahala hore o noe moriana o thibelang likokoana-hloko ka matsatsi a 5-7. Ke nnete, ho ho ngaka ho etsa qeto ya sena. Se ke oa feta ka boithaopo ho feta nako, maqhubu kapa bophahamo ba letsatsi le letsatsi. Ho kotsi ebile ho ka re sokela ka mathata. Haeba phello e sa hlahe ka mofuta oa kalafo o khethiloeng, lithibela-mafu ha li lokele ho loants'oa tšoaetso e itseng.
Ho tsoaetso e matla
Mabapi le nako e boima ea ts'ebetso ea methapo ea methapo, morero oa fetoha. Bakeng sa kalafo, ho khethoa ka litlatsetso tse nang le antibacterial tsa 400 mg. Ba boetse ba laetsoe ho noa makhetlo a mararo ka letsatsi. Phekolo ena e tsamaisoa ke ngaka e eang. Ke liphetoho tse ka etsoang feela ka tumello ea hae. Mohlala, bophahamo ba letsatsi le letsatsi bo eketseha ka karolo ea boraro ho tloha ho khetho e tloaelehileng. Nako ea kalafo e ka nka libeke tse peli. Ho sena, boemo ba mokuli bo bapala karolo ea bohlokoa.
Litlamorao le mathata a teng li ka ba teng joang?
Lithethefatsi tsa antibacterial ke sesebelisoa se sebetsang se fanang ka phello e potlakileng. Ho na le lehlakore le leng le fosahetseng - lenane le tsotehang la karabelo e mpe. Tšusumetso e mpe ea Amoxiclav e thibelang likokoana-hloko hangata e ama mosebetsi oa mpa ea mpa 'me e iponahatsa e le allergy. Tabeng ea pele, ngoana o na le:
- takatso e fosahetseng
- ho hlatsa
- ho nyekeloa
- lets'ollo
- dysbiosis.
Hangata, ho nka Amoxiclav ho tsamaisana le bohloko ba ka mpeng, colitis, ho hloleha ha sebete, hepatitis, jaundice. Ha e le karabelo ea eona ea ho kulisa, e iponahatsa e le:
Ntle le matšoao a mabe a kaholimo, lits'ebetso tse ling tsa 'mele le tsona li ka angoa ke litlamorao tse mpe: hematopoietic, lymphatic, urinary and central system system. Ngoana oa hlaha:
- thrombocytopenia
- leukopenia
- phokolo ea mali
- eosinophilia
- pancytopenia
- krystalluria
- nephritis ea mahareng
- ho tsekela
- hlooho e bohloko
- Ts'oarello
- likhathatso tsa boroko
- ho tšoenyeha ho feteletseng
- cramps.
Lebitso
Lebitso la Serussia la lithethefatsi ke Amoxiclav, Latin - Amoksiklav.
Khoutu ea lithethefatsi ho sehlopha sa ATX (anatomical-therapeutic-chemical) ke J01CR02.
Amoxiclav ke motsoako o thibelang likokoana-hloko o tsoang sehlopheng sa penicillin e sirelelitsoeng.
Lokolla liforomo le sebopeho
Amoxiclav 400 mg e rekisoa ka foromo ea phofo, e tlisoang hore e fumane ho emisoa. Phofo e tšoeu kapa e putsoa hanyane. Sesebelisoa se sebetsang (amoxicillin) se teng ka sebopeho sa 'mele. Palo ea potasiamo ea letsoai la beta-lactamase ke 57 mg. Hammoho le moemeli oa antibacterial, motsoako oa phofo o kenyelletsa gum, sodium benzoate, citric acid, mannitol, flavorings, silicon dioxide le likarolo tse ling. Phofo e pakiloe ka libotlolong (ka pampiri) le lipakete tsa karete.
Matšoao a ho sebelisoa
Amoxiclav 400 e laetsoe mafu a latelang:
- Boloetse ba litho tsa ENT le pampiri e kholo ea ho hema (otitis media, ts'abo ea lisosa, pharyngeal abscess, ho ruruha ha methapo, larynx le pharynx).
- Ho ruruha ha matšoafo le bronchi.
- Mafu a tšoaetsanoang a litho tsa genitourinary litho tsa ka hare (urethritis, cystitis, ho ruruha ha liphio, endometritis, tšenyo ea li-appendages tsa uterine, vulvovaginitis).
- Tšoaetso ea lesapo (osteomyelitis) le lisele tse sebetsanang.
- Ts'oaetso ea maqhubu a gallbladder le bile ducts.
- Ho loma liphoofolo.
- Tšoaetso ea letlalo (pyoderma).
- Maloetse a Odontogenic khahlanong le semelo sa tšenyo ea leino.
Amoxiclav 400 e laetsoe mafu a litho tsa ENT le pampiri e phahameng ea ho hema.
Motsoako o thibelang likokoana-hloko o fuoa kalafo ea mafu a tšoaetsanoang a litho tsa 'mele oa genitourinary litho tsa kahare (urethritis, cystitis)
Ts'oaetso ea lisele tsa masapo le li-activible li laeloa kalafo ea Amoxiclav 400.
Ka ho ruruha gallbladder le ducts tsa bile, sena se thibelang lithibela-mafu se laetsoe.
Amoxiclav e laeloa ho loma liphoofolo.
Moriana o fuoe tšoaetso ea letlalo (pyoderma).
Ka ho ruruha ha matšoafo le bronchi, meriana ena e thibelang mafu e laetsoe.
Moriana ona o sebelisoa haholo ho basali ba basali ba basali.
U ka nka Amoxiclav 400 joang
Ha u fana ka taelo ea bongaka ea kalafo bakeng sa tumello, maemo a lilemo tsa bakuli le maemo a bona a nkuoa.
Motsoako oa batho ba baholo ke 25-45 mg / kg. Tekanyo ea moriana e ka fihla 2,085 mg. Sephutheloana se na le khaba ea ho lekanya e nang le bophahamo ba 5 ml kapa pipette e tlatsitsoeng. Sekhahla se phahameng ka ho fetisisa (bakeng sa amoxicillin) ke 6 g. moriana o nooa habeli ka letsatsi le lijo.
Tekanyetso ea bana
Bakeng sa bana ho tloha ho likhoeli tse 3 ho isa ho selemo se boima ba 5-10 kg, moriana o laetsoe ka litekanyetso tsa ¼ kapa ½ pipette, ho latela boteng ba lefu lena makhetlo a 2 ka letsatsi. Bakeng sa bana ba lilemo li 1-2 le boima ba li-10kg, tekanyetso e khothalletsoang e tsoa ho is ho ¾ lipeipi. Bana ba lilemong tse 2-3 tse nang le boima ba li-kilo tse 15-20 ba beiloe ho tloha ¾ ho isa yuniti e le 'ngoe. Makhetlo a 2 ka letsatsi. Letšoao le ka sehloohong la lipalo hase lilemo, empa boima ba ngoana.
Letšoao le ka sehloohong la lipalo bakeng sa litekanyetso tsa lithibela-mafu ha se lilemo, empa boima ba ngoana.
Phekolo ea ka mpeng
Ha u sebelisa moriana, matšoao a senya ts'ebetsong ea tšilo ea lijo (ho nyekeloa hoa pelo, ho hloka takatso ea lijo, litulo tse otlolohileng kapele, bohloko bo ka mpeng, ho hlatsa) hoa khoneha. Maemong a tebileng, ho na le:
- Jaundice E etsahala ka lebaka la ho thekesela ha bile.
- Hepatitis.
- Pseudomembranous colitis.
- Ho eketseha ha li-enzyme tsa sebete (ALT le AST).
E 'ngoe ea litlamorao tsa ho nka moriana e ka ba tsoelo-pele ea lefu la sebete.
Pseudomembranous colitis ke e 'ngoe ea lisosa tsa ts'ebeliso ea Amoxiclav.
Maemong a tebileng, ho na le keketseho e 'ngoe ea li-enzyme tsa sebete.
Ha u sebelisa moriana o thibelang likokoana-hloko maemong a matla, jaundice e bonoa.
Ha u sebelisa moriana, matšoao a ho senya litho tsa ka mpeng (ho nyekeloa ke pelo, ho hloka takatso ea lijo) lia khonahala.
Ho tsoa ts'ebetsong ea moroto
Bakuli ba bang ba tšoaroa ke nephritis (ho ruruha ha liphio). Bongata bo bongata ba letsoai bo ka hlaha ka har'a moroto.
Ha u sebelisa Amoxiclav, ho hlaha lintho tse kulang (redness ea letlalo, leqhetsoana la pampiri ea mofuta oa urticaria, ho hlohlona, angioedema, dermatitis, makala le Stevens-Johnson syndrome).
Ha u sebelisa Amoxiclav, ho hlaha lintho tse kulang (redness ea letlalo, leqhetsoana la pampiri ea mofuta oa urticaria, ho hlohlona, joalo-joalo).
Ho sebelisana le lithethefatsi tse ling
Ts'ebeliso e tšoanang ea Amoxiclav 400 e nang le li-antacids, li-chondroprotectors tsa glucosamine, li-aminoglycosides, lithibela-pelehi tsa molomo, methotrexate, allopurinol, disulfiram, anticoagulants, macrolides, lithibela-mafu tse tsoang sehlopheng sa tetracycline le sulfonamides ha li khothalletsoe. E fokotsa khatello ea kelello ea Amoxiclav Probenecid.
Keketseho ea khatello ea amoxiclav maling e khothaletsoa ke:
Li-analog tsa Amoxiclav 400 ke Amoxiclav Quiktab le Augmentin (tharollo ea ente e ka lokisoa ho tsoa ho eona).
Analogue ea Amoxiclav 400 ke Augmentin.
Letsatsi la ho felloa ke nako
Phofo e bolokiloe lilemo tse 2 ho tloha ka letsatsi leo e neng e hlophisoa ka eona. Ho emisoa ho phethiloeng ho loketse beke haeba ho bolokiloe sehatsetsing ka mocheso oa + 2 ... + 8ºC ka botlolo e koetsoeng.
Maikutlo a ngaka mabapi le lithethefatsi Amoxiclav: matšoao, tsamaiso, litla-morao, litataiso tsa Amoxiclav bakeng sa ho sebelisa matlapa a Amoxiclav Amoxiclav | analogues
Tlhahlobo ea Amoxiclav 400
Litlhahlobo tsa litsebi le batho ba sebelisitseng sehlahisoa sa litlhare li ntle haholo.
Yuri ea lilemo li 47, Kostroma o re: “Amoxiclav hangata e fuoa bakuli ba ka ba nang le mafu a ho ruruha a litho tsa botona tsa botšehali. Phekolo e sebetsa hantle haholo ho latela melao ea bohloeki ba basali. ”
Valery, ea lilemo li 32, Vorkuta: “Amoxiclav e thusa hantle ka ts'oaetso ea litho tsa ENT, ho kenyeletsa tsebe e bohareng. Setlhare sena ha se theko e phahameng ebile se fana ka litlamorao. "
Alena ea lilemo li 28, Moscow, o re: “Haufinyane tjena ngoana ea lilemo li 4 o fumanoe a e-na le lefu la bronchitis. E sebetsana le Amoxiclav 400 ka foromo ea phofo. Pheko e ntle. ”
Foromo ea boholo:
phofo bakeng sa ho emisoa bakeng sa tsamaiso ea molomo.
Mong le e mong 5 ml ea ho emisoa ha 400 mg + 57 mg / 5 ml e na le:
Lintho tse sebetsang: amooticillin (ka sebopeho sa trihydrate) ho latela ntho e sebetsang - 400 mg, clavulanic acid (ka sebopeho sa letsoai la potasiamo) ho latela ntho e sebetsang - 57 mg, Baeti: citric acid (anhydrous) - 2.694 mg, sodium citrate (anhydrous) - 8.335 mg, cellcrystalline cellulose le sodium carmellose - 28.1 mg, xanthan gum - 10.0 mg, colloidal silicon dioxide - 16,667 mg, silicon dioxide - 0,217 g, ho natefeloa ha ciliegia e hlaha - 4,000 mg, tatso ea linoko - 4,000 mg, sodium saccharinate - 5 500 mg, mannitol ho fihlela ho 1250 mg.
Mong le e mong 5 ml ea ho emisoa ha 250 mg + 62,5 mg / 5 ml e na le:
Lintho tse sebetsang: amooticillin (ka sebopeho sa hydrocrate) ho ya ka ntho e sebetsang - 250 mg, clavulanic acid (ka sebopeho sa letsoai la potasiamo) ho latela ntho e sebetsang - 62,5 mg, Baeti: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, cellcrystalline cellulose le sodium carmellose - 28.1 mg, xanthan gumthan - 10,0 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0,217 g, tatso ea monokotšoai o hlaha - 4,000 mg, sodium saccharinate - 5 500 mg, mannitol ho fihlela ho 1250 mg.
Mong le e mong 5 ml ea ho emisoa ha 125 mg + 31.25 mg / 5 ml e na le:
Lintho tse sebetsang: amooticillin (ka sebopeho sa trihydrate) ho latela sesebelisoa se sebetsang - 125 mg, clavulanic acid (ka sebopeho sa letsoai la potasiamo) ho latela ntho e sebetsang - 31.25 mg, Baeti: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, "cellcrystalline cellulose" le "sodium carmellose" 28.1 mg, xanthan gumthan - 10,0 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0,217 g, tatso ea fragola - 15,000 mg, sodium saccharinate - 5 500 mg, mannitol ho fihlela ho 1250 mg.
Tlhaloso: phofo: ho tloha tšoeu ho isa ho 'mala o mosehla.
Ho emisoa hoo e batlang e le bosoeu ho emisa homogeneous ukumisoa.
Melemo ea pharmacological
Mofumahali
Mokhoa oa ketso
Amoxicillin ke motsoako o mongata oa tlhaho o pharalletseng o nang le lintho tse khahlanong le likokoana-hloko tse ngata tse ntle tsa gram le gram-negative. Ka nako e ts'oanang, amoxicillin e kotsing ea ho felisoa ke beta-lactamases, ka hona bongata ba ts'ebetso ea amoxicillin ha bo fetele ho likokoana-hloko tse hlahisang enzyme ena.
Clavulanic acid, beta-lactamase inhibitor e amanang le penicillin, e khona ho inactivate ea mefuta e mengata ea beta-lactam e fumanoang penicillin le cephalosporin e loants'ang likokoana-hloko. Clavulanic acid e na le katleho e lekaneng khahlanong le plasmid beta-lactamases, eo hangata e ikarabellang bakeng sa ho hanyetsa baktheria, mme e sa sebetse khahlano le mofuta oa I chromosome beta-lactamases, e sa thibeloang ke clavulanic acid.
Ho ba teng ha clavulanic acid ha e ntse e hlophisoa ho sireletsa amoxicillin hore e se ke ea senngoa ke li-enzyme - beta-lactamases, tse lumellang ho holisa bongata ba li-antibacterial.
Se latelang ke ts'ebetso ea motsoako oa amoxicillin le clavulanic acid in vitro.
| Lifofane tse khothatsang: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus pyogene 1,2, Streptococcus agalactiae 1,2, tse ling beta-hemolytic steptococci 1,2, Staphylococcus aureus (methicillin-sens) 1, Staphylocus c) coagulase-negative staphylococci (e amehang ka methicillin). Lirosa tse senang maikutlo: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae. Tse ling: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum. Li-anaerobes tsa Gram: mefuta ea mofuta oa Clostridium, Peptococcus niger, Peptostrepiococcus magnus, Peptostreptococcus micros, mefuta ea mofuta oa Peptostreptococcus. Li-anaerobes tsa Gram-negative: Bacteroides fragilis, mefuta ea mofuta oa Bacteroides, mefuta ea mofuta oa capnocytophaga, Eikenella corrodens, Fusobacterium nucleatum, mefuta ea genus Fusobacterium, mefuta ea genus Porphyromonas, mefuta ea mofuta oa Prevotella. |
| Bacteria eo ho eona motho a ileng a hanyetsa e ka ba teng motsoako oa amoxicillin le clavulanic acid |
| Gram-negative aerobes: Escherichia coli1, Klebsiella oxytoca, Klebsiella pneumoniae, mefuta ea mofuta oa Klebsiella, Proteus mirabilis, Proteus vulgaris, mefuta ea mofuta oa Proteus, mefuta ea mofuta oa Salmonella, mofuta oa mofuta oa Shigella. Streptococcus pneumoniae 1,2, streptococci ea sehlopha sa Viridans. Lifofane tse khothatsang: mefuta ea mofuta oa Corynebacterium, Enterosocus faecium. |
| Bacteria e Hanang ka Toka motsoako oa amoxicillin le clavulanic acid |
| Lirosa tse senang maikutlo: mefuta ea genus Acinetobacter, Citrobacter freundii, mefuta ea mofuta Enterobacter, Hafnia alvei, Legionella pneumophila, Morganella morganii, mefuta ea mofuta oa Providencia, mefuta ea mofuta oa Pseudomonas, mefuta ea mofuta oa Serratia, Stenotrophomonas maltophilia, Yersinia. Tse ling: Chlamydia pneumoniae, Chlamydia psittaci, mofuta oa mofuta oa Chlamydia, Coxiella burnetii, mofuta oa mofuta oa Mycoplasma. 1 bakeng sa libaktheria tsena, ho sebetsa hantle ha kliniki ho kopantseng amoxicillin le clavulanic acid ho bontšitsoe lithutong tsa bongaka. Likhetla tse peli tsa mefuta ena ea libaktheria ha li hlahise beta-lactamase.Sensitivity le amoxicillin monotherapy e fana ka maikutlo a tšoanang le a kopantsoeng ea amoxicillin le clavulanic acid. |
Mofumahali
Suction
Lithako tse mafolofolo tsa moriana li kenella ka potlako le ka botlalo ho tsoa mpeng ea gastrointestinal (GIT) kamora ho tsamaisoa ka molomo. Ho fufuleloa ha lintho tse sebetsang ho nepahetse maemong a ts'ebeliso ea lithethefatsi ka lijo.
Ka tlase ke paramethara ea pharmacokinetic ea amoxicillin le clavulanic acid kamora tsamaiso ka tekanyo ea 45 mg / 6.4 mg / kg, e arotsoe ka litekanyetso tse peli, ke bakuli ba ka tlase ho lilemo tse 12.
Boleng bo tloaelehileng ba paramente ea pharmacokinetic
Сmax - boholo ba mahloriso a plasma,
Tmax - nako ea ho fihlela mahloriso a mangata a plasma,
AUC ke sebaka se tlas'a "cur-time" Curve "
T1 / 2 - halofo ea bophelo.
Metabolism
Hoo e ka bang 10-25% ea tekanyetso ea pele ea amoxicillin e hlahisoa ke liphio e le metabolite e sa sebetseng (penicilloic acid). Clavulanic acid e kahara 'mele oa motho e kenella metabolism e matla ha ho thehoa 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid le 1-amino-4-hydroxy-butan-2-e ngoe 'me e fafalitsoe ke liphio, ka mpeng ea tšilo ea lijo, hammoho le moea o felang, ka khabone ea khabone.
Tsamaiso
Joalo ka kopants'o e kenelletseng ea amoxicillin le clavulanic acid, kalafo ea methapo ea amoxicillin le clavulanic acid e fumanoa linthong tse fapaneng le mokelikeli oa methapo (ka mokokotlong, mathoasong a mpa ea mpa, letlalo, adipose le mesifa ea mokokotlo, mokelikeli oa manonyeletso le oa pele). .
Amoxicillin le clavulanic acid li na le tekanyo e fokolang ea ho tlama liprotheine tsa plasma. Boithuto bo bontšitse hore 25% ea kakaretso eohle ea clavulanic acid le 18% ea amoxicillin e plasma ea mali e lumellana le liprotheine tsa plasma.
Bophahamo ba phepelo e batla e le 0,3-0.4 L / kg bakeng sa amoxicillin le boholo ba 0,2 L / kg bakeng sa clavulanic acid.
Amoxicillin le clavulanic acid ha li tšeloe ke tšitiso ea mali le methapo ea letsoho e sa amaneng. Amoxicillin (joalo ka penicillin e ngata) e pepesetsoa lebeseng la matsoele.
Khoele ea clavulanic acid le eona e ka fumanoa lebeseng. Ntle le monyetla oa ho susumetsa maikutlo, letšollo, le candidiasis ea mucosa ea molomo, ha ho na litlamorao tse ling tse mpe tsa amoxicillin le clavulanic acid e mabapi le bophelo bo botle ba masea a anyesitsoeng.
Boithuto ba ho tsoala liphoofolo bo bontšitse hore amoxicillin le clavulanic acid li tšela mokoallo oa placental. Leha ho le joalo, ha ho na litla-morao tse bohloko tse fumanoeng ho lesea.
Ho tsala
Amoxicillin e hloekisoa haholo ke liphio, athe clavulanic acid e sebelisa methapo ea kutlo le e meng. Kamora taolo e le 'ngoe ea molomo ea 875 mg / 125 mg kapa 500 mg / 125 mg, hoo e ka bang 60-70% ea amoxicillin le 40-65% ea clavulanic acid li hlahisoa li sa fetoloe ke liphio nakong ea lihora tse 6 tsa pele.
Bophara ba halofo ea bophelo (T1 / 2) ea amoxicillin / clavulanic acid ke hoo e ka bang hora e le ngoe; kakaretso e hlakileng ea botlalo e ka ba 25 l / h ho bakuli ba phetseng hantle. Nakong ea lithuto tse fapaneng, ho ile ha fumaneha hore excretion ea amoxicillin ke liphio ka nako ea lihora tse 24 e batla e le 50-85%, clavulanic acid - 27-60%.
Tekanyo e kholo ka ho fetisisa ea clavulanic acid e qhekelloa nakong ea lihora tse peli tsa pele kamora tsamaiso.
The pharmacokinetics of amooticillin / clavulanic acid ha e ea itšetleha ka bong ba mokuli.
Bakuli ba nang le ts'oaetso ea renal
Tlhahiso e felletseng ea amoxicillin / clavulanic acid e fokotseha ka mokhoa o lekanang le ho fokotseha ha ts'ebetso ea lipholiso. Thibelo e fokotsehileng e phatlalatsoa haholo bakeng sa amoxicillin ho fapana le acid ea clavulanic, hobane boholo ba amoxicillin bo bonoa ke liphio. Melemo ea moriana bakeng sa ho hloleha ha a liphio e lokela ho khethoa ho nahanela ho se sebetse hantle ha cumulation ea amoxicillin ha e ntse e boloka boemo bo tloaelehileng ba clavulanic acid.
Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng
Bakeng sa bakuli ba nang le ts'ebetso ea sebete e sa sebetseng, setlhare se sebelisoa ka hloko. Hoa hlokahala hore a lule a lekola ts'ebetso ea sebete.
Lintho tsena ka bobeli li tlosoa ke hemodialysis le lintho tse nyane ka peritoneal dialysis.
Sebelisa nakong ea bokhachane le nakong ea ho anyesa
Liphuputso tsa liphoofolo ha lia senola datha mabapi le kotsi ea ho sebelisa moriana nakong ea kemolo le phello ea eona kholong ea bongoana.
Phuputso e 'ngoe ho basali ba nang le ho phatloha ho sa potlakileng ha litho tsa kahare tsa amniotic e fumane hore phekolo ea prophylactic e nang le amoxicillin / clavulanic acid e ka amahanngoa le kotsi e eketsehang ea necrotizing enterocolitis ho masea a sa tsoa hlaha.
Nakong ea bokhachane le pelehi, moriana o sebelisoa feela ha lehlohonolo le boletsoeng ho mme le feta kotsi e ka bang teng ho lesea le lesea.
Amoxicillin le clavulanic acid ka bongata bo kenang ka lebese la matsoele, ka hona, ho nka moriana nakong ea kanyeso ho lokela ho tsoelapele ha feela ho na le lipontšo tse hlakileng.
Ho masea a amohelang letsoele, nts'etsopele ea maikutlo, letšollo, li-candidiasis tsa mucous membrous ea cavity ea molomo lia khoneha. Maemong a joalo, ho anyesa ho lokela ho emisoe.
Litla-morao
Ho latela Mokhatlo oa Lefatše oa Bophelo (WHO), karabelo e mpe e aroloa ho latela khafetsa ea ntlafatso ea bona: khafetsa (> 1/10), khafetsa (> 1/100, 1/1000, 1/10000, ho tsoa lintlheng tsa hematopoietic le lymphatic tsamaiso
ka seoelo: leukopenia e fetolelang (ho kenyeletsoa neutropenia), thrombocytopenia,
ka seoelo: eosinophilia, thrombocytosis, agranulocytosis e fetohang, keketseho ea nako ea ho tsoa mali le keketseho e khutlang ea nako ea prothrombin, phokolo ea mali, ho kenyelletsa le anemia e khutlisetsoang hemolytic.
Ho tsoa sesole sa 'mele
ka seoelo: angioedema, anaphylactic reaction, allergic vasculitis, lefu le ts'oanang le lefu la serum.
Ho tsoa tsamaisong ea methapo
khafetsa: ho tsekela, hlooho,
ka seoelo: ho hloka boroko, ho ruruha, ho tšoenyeha, ho fetoha ha boitšoaro, ho feto-fetoha ha maikutlo, ho tsitsipana, ho tsitsipana ho ka etsahala ho bakuli ba nang le ts'ebetso ea renal e sa sebetseng, hammoho le ho ba fumanang litekanyetso tse phahameng tsa moriana.
Ho tsoa pampiring ea ka mpeng
khafetsa: ho felloa ke takatso ea lijo, ho nyekeloa ke pelo, ho hlatsa, lets'ollo,
Ho nyekeloa ke pelo ho bonahala hangata ha ho monya tekanyetso e phahameng. Haeba litlolo tsa ts'ebetso ea ka mpeng li tiisitsoe, li ka felisoa haeba u sebelisa moriana qalong ea lijo.
khafetsa: ho koenya ho koatile
ka seoelo: colitis e amanang le lithibela-mafu e hlohlelletsoa ke ho nka lithibela-mafu (ho kenyeletsa le pseudomembranous le hemorrhagic colitis), leleme le letšo "le lesoeu", gastritis, stomatitis.
Ho bana, ho khetholloa ha bokaholimo ba enamel ea meno ho ne ho sa bonoe haholo. Tlhokomelo ea molomo e thusa ho thibela ho entsoe ha enamel ea meno.
Karolong ea letlalo
khafetsa: lekhopho la letlalo, ho hlohlona, urticaria,
ka seoelo: erythema multiforme exudative,
ka seoelo: Stevens-Johnson Syndrome, chefo e ka fokotsang lefu la sethoathoa, dermatitis e ngata haholo, le pustulosis e matla e akaretsang.
Ho tsoa ts'ebetsong ea moroto
ka seoelo: crystalluria, nephritis ea mahareng, hematuria.
Karolong ea sebete le pampiri ea biliary
khafetsa: ts'ebetso e eketsehileng ea alanine aminotransferase (ALT) le / kapa aspartate aminotransferase (AST), (ketsahalo ena e bonoa ho bakuli ba fumanang kalafo ea lithibela-mafu tsa beta, empa bohlokoa ba eona ba kliniki ha bo tsejoe).
Liketsahalo tse bohloko tse tsoang ho sebete li ile tsa bonoa haholo ho banna le bakuli ba tsofetseng mme li ka amahanngoa le kalafo ea nako e telele. Liketsahalo tsena tse bohloko ha li atisoe hangata ho bana.
Matšoao le matšoao a thathamisitsoeng hangata a hlaha nakong ea kalafo kapa hang ha a qeta, leha ho le joalo maemong a mang a kanna a se ke a hlaha libeke tse 'maloa kamora ho qeta kalafo. Liketsahalo tse fapaneng hangata lia fetoha.
Liketsahalo tse mpe tse tsoang ho sebete li ka ba matla, maemong a sa tloaelehang haholo ho bile le litlaleho tsa sephetho se bolaeang. Hoo e batlang e le maemong ohle, bana e ne e le batho ba nang le methapo e meholo ea ho kopana kapa ba neng ba amohela meriana e tšoanang ea hepatotoxic.
ka seoelo: keketseho ea alkaline phosphatase, keketseho ea bilirubin, hepatitis, cholestatic jaundice (e tsebisoang ka kalafo e kopaneng le penicillin le li-cephalosporins tse ling).
Tse ling
khafetsa: candidiasis ea letlalo le membrane ea mucous,
maqhubu a sa tsejoeng: kholo ea likokoana-hloko tse sa tsotelleng.
Fomu ea tokollo
Phofo bakeng sa ho emisoa ka molomo
Bakeng sa litekanyetso tsa 125 mg + 31.25 mg / 5 ml le 250 mg + 62,5 mg / 5 ml:
Ho paka ka mantlha: 25 g ea phofo (100 ml ea ho emisoa ho felisitsoeng) ka khalase e lefifi ea khalase e nang le letšoao la mehele (100 ml). Botoro e koetsoe ka sekoti se entsoeng ka polyethylene e phahameng e nang le reng e laolang, e nang le selika-likoe se kahare, ka har'a cap, kapa screw metal cap, e nang le reng e laolang, kahare ho cap ena ho na le gasket e entsoeng ka polyethylene e tlaase.
Ho paka ka bobeli:
Botoro e le 'ngoe e nang le khaba ea litekanyetso e nang le matšoao a potileng a 2,5 ml le 5 ml ("2,5 SS" le "5 SS"), letšoao le leholo la 6 ml ("6 SS") letsohong la khaba le litaelo bakeng sa khaba ts'ebeliso ea bongaka ka lebokoseng la karete.
Botlolo e le 'ngoe e nang le pampette ea litekanyetso tsa litekanyetso le litaelo bakeng sa tšebeliso ea bongaka ka lebokoseng la karete.
Bakeng sa litekanyetso tsa 400 mg + 57 mg / 5 ml:
Ho paka ka mathomo: 8,75 g (35 ml ea ho emisoa ho felileng), 12,50 g (50 ml ea ho emisoa ho felileng), 17.50 g (70 ml ea ho emisoa ho felileng) kapa 35.0 g (140 ml ea ho emisoa ho felileng) phofo ka botlolong e lefifi. khalase e nang le screw cap e entsoeng ka polyethylene e phahameng haholo ka lesakaneng la taolo hape e na le tiiso ea tapered kahare ho cap.
17.50 g (70 ml ea ho emisoa ho felileng) ka botlolong ea khalase e lefifi e nang le letšoao la mehele (70 ml) e nang le sekoti se entsoeng ka polyethylene e phahameng e nang le reng e laolang hape e nang le tiiso ea conical kahare ho cap.
Ho paka ka bobeli:
Botlolo e le 'ngoe e nang le pampette ea litekanyetso tsa litekanyetso le litaelo bakeng sa tšebeliso ea bongaka ka lebokoseng la karete.
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Lefu la Tsoekere
Lefu la tsoekere le tsohle tse mabapi le lona Li-pathologies tsohle tsa letlalo li arotsoe ka lihlopha tse peli tse kholo. maqeba a letlalo a bakoang ke mathata a lefu la tsoekere, haholoholo, neuro- le angiopathy, hammoho le mathata a metabolic. ... -
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