Taeo ea extentsef

Extentsef E sebelisoa ho phekola tšoaetso e bakoang ke likokoana-hloko tse amehang ho moriana:
- tšoaetso e tlase ea phepelo ea methapo: ho ruruha ha pelo le ho mpefala ha lefu la bronchitis, pneumonia
- ts'oaetso ea ts'ebetso ea moroto: pyelonephritis, cystitis, urethritis le prostatitis
- tšoaetso ea letlalo le lisele tse bonolo,
- tšoaetso ea ka mpeng: peritonitis, tšoaetso ea phepelo ea mala,
- mafu a gynecological,
- septicemia,
- kalafo e matla bakeng sa febrile neutropenia,
- bacterial meningitis.

Ba boholong litabeng tsa bongaka

Tsefepim prignіchuмент synthes of enzymes ea bacteritum klitini і ma є bophara ba mefuta e fapaneng ea sebaktheria se nepahetseng le se setle sa gram. Cephepium e bonahala haholo ho hydrolysis ea b-lactamase, tlholisano e nyane e fumanoa boteng ba b-lactamase, e kenyelelitsoeng ka liphatsa tsa lefutso tsa chromosome, le ho kenella ka shvidko liseleng tsa baktheria tse se nang gram.

Tsefepіm schodo e sebetsang ea likokoana-hloko tse joalo:

grampositive aerobi:Staphylococcus aureus hore Staphylococcus epidermidis (ho kenyeletsa šx shtami, scho hlahise b-lactamase), іshi shti stafіlokokіv, e kenyeletsang S. hominis, S. saprophyticus, Streptococcus pyogene (sehlopha A streptococci), Streptococcus agalactiae (Sehlopha sa Streptococcus B), Streptococcus pneumoniae (incl. e nang le shtami ho tloha setaele se bohareng ho isa penicillin - mofuta oa IPC 0 ho isa ho 1 μg / ml), b-hemolytic streptococci (lihlopha C, G, F), S. bovis (sehlopha D), sehlopha streptococci Likokoana-hloko. (Bіlshіst straіnt enterokokіv, mohlala: Enterecoccus faecalis, staphylococcus, e hananang le methicillin, e hananang le lithibela-mafu tse matla tsa cephalosporin, ho kenyeletsoa le cefepim).

Gram-negative aerobi:Pseudomonas spp ., ho kenyelletsa P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiella sppK. pneumoniae, K. oxytoca, K.aleenae, Enterobacter spp E. cloacae, E. aerogene, E. agolomeratus, E. sakazakii, Proteus spp P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp. anitratus lwoffi), Aeromonas hydrophila, Capnocytophaga spp., Citrobacter spp C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. influenzae (ho kenyeletsoa le shtami, ho hlahisa beta-lactamase), H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis ( Branhamella catarrhalis) (ho kenyeletsoa le shtami, ho hlahisa b-lactamase), Neisseria gonorrhoeae (ho kenyeletsoa le shtami, ho hlahisa b-lactamase), Nessera meningitidis, Pantoea agglomerans (vіdomiy yak Enterobacter agglomerans), Providencia spp. (ho kenyeletsaP. rettgeri, P. stuartii), Salmonella spp., Serratia (ho kenyeletsa S. marcescens, S. liquefaciens), Shigella spp., Yersinia enterocolitica.

(Cefepim ha e sebetse Xanthomonas maltophilia i Pseudomonas maltophilia),

anaerobi:Libaktheria spp., B. melaninogenicus, robala ho Libaktheria, Clostridium perfringens, Fusobacterium spp., Mobiluncus spp., Peptostreptococcus spp., Veillonella spp.

(Cefepim ha e sebetse Bacteroides fragilis і Clostridium Hardile).

Karolelano ea kakaretso ea cefepima ho plasma ka hora e bulehileng kamora hore ho be le taolo ea nako e le 'ngoe ea khatello le methapo ea kutlo e tafoleng.

Ts'oarello ea plasma ho plasma (μg / ml) kahare (intravenous) le kahare (intravenous) intravenous

Melemo ea pharmacological

Cepepime inhibuse motsoako oa li-enzyme tsa "cell bacteria" mme e na le ts'ebetso e fapaneng mabapi le libaktheria tse fapaneng tsa gram le gram-negative. Cepepime e hanela hydrolysis haholo ke li-b-lactamase tse ngata 'me e na le kamano e tlase bakeng sa li-b-lactamase tse kentsoeng ke liphatsa tsa lefutso tsa chromosomal,' me e kenella ka potlako liseleng tsa baktheria tse se nang gram.

Cepepime e sebetsa khahlano le likokoana-hloko tse latelang:

aerobes e ntleStaphylococcus aureus le Staphylococcus epidermidis ( ho kenyelletsa likarolo tsa bona tse hlahisang b-lactamase) mefuta e meng ea staphylococci, ho kenyeletsoa S. hominis, S. saprophyticus, Streptococcus pyogene (Sehlopha sa Streptococcus A), Streptococcus agalactiae (Sehlopha sa Streptococcus B), Streptococcus pneumoniae (ho kenyeletsoa mefuta e meng e hanyetsanang le penicillin - MIC ho tloha 0,1 ho isa 1 /g / ml), li-b-hemolytic streptococci (lihlopha C, G, F), S. bovis (sehlopha D), sehlopha streptococci Likokoana-hloko . (Ka mohlala, mefuta e mengata ea enterococci Enterecoccus faecalis, le staphylococci e thibelang methicillin e loantšoa le lithibela-mafu tse ngata tsa cephalosporin, ho kenyeletsoa le nako ea cefepime)

Gram aerobes e mpePseudomonas spp ., ho kenyelletsa P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiella spp K. pneumoniae, K. oxytoca, K.aleenae, Enterobacter spp E. cloacae, E. aerogene, E. agolomeratus, E. sakazakii, Proteus spp P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp. Anitratus lwoffi ) , Aeromonas hydrophila, Capnocytophaga spp., Citrobacter spp C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. influenzae (ho kenyeletsoa mefuta e hlahisang beta-lactamase) H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis ( Branhamella catarrhalis ) (ho kenyeletsoa le b-lactamase e hlahisang likarolo) Neisseria gonorrhoeae (ho kenyeletsoa mefuta e hlahisang b-lactamase) Nessera meningitidis, bahanyetsi ba Pantoea (ba tsejoang e le Enterobacter agglomerans) Providencia spp. (ho kenyeletsa P. rettgeri, P. stuartii ) Salmonella spp., Serratia (ho kenyeletsa S. marcescens , S. liquefaciens) Shigella spp., Yersinia enterocolitica .

(Cefepime ha e sebetse ka mefuta e mengata Xanthomonas maltophilia le Pseudomonas maltophilia )

anaerobes:Libaktheria spp., B. melaninogenicus amanang le Libaktheria , Clostridium perfringens, Fusobacterium spp., Mobiluncus spp ., Peptostreptococcus spp., Veillonella spp.

(Cefepime ha e sebetse ka Bacteroides fragilis le Clostridium Hardile ).

Kakaretso ea plasma ea cefepime ka linako tse fapaneng kamora ho kenngoa ka ente e le 'ngoe le ea methapo ka har'a tafole.

Plasma cefepime concentrations (mcg / ml) ka methapo (i / v) le tsamaiso ea methapo (i / m)

Mokhoa oa kopo

mesifa. Bakeng sa tsamaiso ea jete, tekanyo e le 'ngoe ea lithethefatsi e hlapolotsoe ho 5 kapa 10 ml ea isotonic sodium chloride solution, tharollo ea glucose ea 5% kapa metsi a sa hlapolloang bakeng sa ente mme o ente butle ka nako ea metsotso e 3 - 5.
Ka ho hlohlona kahare ho moriana, 500 kapa 1000 mg e hlapolotsoe ka 100 - 250 ml ea tharollo ea isotonic sodium chloride kapa tharollo ea 5% ea glucose, tsamaiso e etsoa bonyane metsotso e 30.

Bakeng sa batho ba baholo.
Tšoaetso ea pampiri ea urinary, e bonolo ho isa tekanyong: 500 mg - 1 g kahare kapa ka methapo ka 'ngoe ka 12:00
Tšoaetso, bonolo ho isa tekanyong ea 1 g kahare kapa ka methapo e 'ngoe le e' ngoe ka 12:00
Tšoaetso e matla: 2 g mong le e mong 12:00
Ts'oaetso e mpe haholo le e behang bophelo ba 2 g nako le nako ea 8:00
Bakeng sa bakuli ba nang le bothata ba ho sebetsa ha renal (tumello ea tumellano ea tlhahiso ea tlhahiso ea likhalase 60 ho isa ho tse ling le tse ling le tse ling tse 12:00, 1 g, ka hora e ngoe le e ngoe ka 12:00 bosiu.
30 - 50 Phetoho ea khaba ho latela tumello ea "creatinine"
2 g, ka makhetlo a mang le a mang a 12:00, 2 g, lihora tse ling le tse ling tse 24 g, lihora tse 24 le tse ling 500 mg mg ka lihora tse 24
11 - 29 2 g, lihora tse ling le tse ling tse 24 g, lihora tse ling le tse ling tse 24, 500 mg ka nako e 'ngoe le tse ling tse 24 lihora tse 500 ka mg

Ba boholong litabeng tsa meriana.

Tsefepim prignіchuмент synthes of enzymes ea bacteritum klitini і ma є bophara ba mefuta e fapaneng ea sebaktheria se nepahetseng le se setle sa gram. Cephepium e bonoa haholo ho hydrolysis ea b-lactamase, ha ho na tlholisano e nyane bakeng sa b-lactamase, e entsoe ka liphatsa tsa lefutso tsa chromosome, mme e bitsoa haholo ka lisele tsa libaktheria tse se nang gram.

Tsefepіm schodo e sebetsang ea likokoana-hloko tse joalo:

grampositive aerobi:Staphylococcus aureus hore Staphylococcus epidermidis (Ho kenyelletsa шхні shtami, scho hlahisa b-lactamase), інші shtami stafіlokokіv, ho kenyelletsa S. hominis, S. saprophyticus, Streptococcus pyogene (sehlopha A streptococci), Streptococcus agalactiae (Sehlopha sa Streptococcus B), Streptococcus pneumoniae (ho kenyelletsa le setaele sa boemo bo bohareng ho fihlela penicillin - boholo ba mahloriso ke 0.1 ho 1 μg / ml), b-hemolitic streptococci (lihlopha C, G, F), S. bovis (sehlopha D), sehlopha streptococci Likokoana-hloko. (Bіlshіst strainіnterokokіv, mohlala Enterecoccus faecalis, ст staphylococci e hananang le methicillin, e hananang le lithibela-mafu tse matla tsa cephalosporin, ho kenyeletsoa le cefepim).

Gram-negative aerobi:Pseudomonasspp., ho kenyelletsa P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiellaspp., ho kenyelletsa K. pneumoniae, K. oxytoca, K.aleenae, Enterobacter spp., ho kenyelletsa E. cloacae, E. aerogene, E.agolomeratus, E. sakazakii, Proteusspp., ho kenyelletsa P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp.anitratus lwoffi), Aeromonas hydrophila, Capnocytophagaspp., Citrobacterspp., ho kenyelletsa C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. influenzae (ho kenyeletsoa le shtami, ho hlahisa beta-lactamase), H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis (Branhamella catarrhalis) (ho kenyeletsoa ke shtami, scho hlahisa b-lactamase), Neisseria gonorrhoeae (ho kenyeletsoa le shtami, tlhahiso ea b-lactamase), Nsethalameningitidis, Pantoea agglomerans ( vidomy yak Enterobacter agglomerans), Providencia spp. (ho kenyeletsa P. rettgeri, P. stuartii), Salmonella spp, Serratia (ho kenyeletsa S. marcescens, S. liquefaciens), Shigellaspp., Yersinia enterocolitica.

(Cefepim ha e sebetse Xanthomonas maltophilia і Pseudomonas maltophilia),

anaerobi:Bacteroides spp. , B. melaninogenicus, robala ho Libaktheria, Clostridium perfringens, Fusobacterium spp., Mobiluncus spp., Peptostreptococcus spp., Veillonella spp. (Cefepim ha e sebetse Bacteroides fragilis і Clostridium Hardile).

Karolelano ea kakaretso ea cefepima ho plasma ka hora e bulehileng kamora hore ho be le taolo ea nako e le 'ngoe ea khatello le methapo ea kutlo e tafoleng.

Plasma e kenella ho plasma (μg / ml) kahare (intravenous) le kahare 'ulcerative (intravenous)

Sich, zhovchі, peritoneal retinitis, li-secity tsa mucous tsa li-tubes tsa bronchial, sputum, prostate, sehlomeloang le zhovnichny mikhury le tsona li na le kalafo e tebileng ea cefepime.

Bohareng ba nako napivvidendenny cefepіmu le sebopuoa e ba hoo e ka bang lilemo tse 2. Ka lebaka la batho ba phetseng hantle, ka lebaka leo, litekanyetso tse ka bang 2 g li ile tsa kenngoa kahare ka nako e telele ea lilemo tse 8, matsatsi a 9 a ts'oanang, cumulation ea lithethefatsi 'meleng ha ea ka ea phahamisoa.

Cepepime e tšeloa N-methylpyrrolidine, 'me e kenngoa ka sekhahla ho N-methylpyrolidine oxide. Mahare a mahareng a lagalny a fetoha 120 ml / hv. Tsefepim e ka bonoa esita le vinyatkovo bakeng sa mahogany ea mekhoa e tloaelehileng - boemo bo ka sehloohong ke seaparo sa glacerular filtration (karolelano ea tumello ea nirkovy - 110 ml / hv). Hoo e ka bang 85% ea tekanyetso e tlositsoeng ea khoeli ea konkrese e sa buloang, 1% N-methylpyrolidine, e ka bang 6.8% ea N-methylpyrolidine oxide, le hoo e ka bang 2,5% ea nako ea khefu e bonahetse. Molumo oa cefepime o nang le li-block tsa plasma tsa mali o fetoha tlase ho 19% mme o se ke oa bua leshano ka ts'ebeliso ea lithethefatsi maling.

Bakeng sa batho ba kulang ba nang le maikutlo a 65 a ts'ebetso e tloaelehileng, ha ho hlokahale hore ba fetole lethal dose ho cefepim, mme boholo ba tumello ea nickel bo ikemetse ho ba banyane.

Tlaleho e fetileng, e etselitsoeng pheletso ea ba nang le bothata bo boholo ba ho fokolloa ke bophelo, e bontšitse nako e hlophisitsoeng khafetsa. Nakong ea bohareng, ho etsa mohlala, bathong ba kulang ba nang le ts'ebetso e tebileng ea ts'ebetso, ke hloka ho batla tsela e nyane ka ho bala, ho ba le lilemo tse 13 ka hemodialysis le lilemo tse 19 ka lefu la methapo ea methapo.

Pharmacokinetics ea cefepim maemong a ho kula a sitisang mosebetsi oa sebete ha e tšoaetsoe ke mucoviscidosis. Corriguvanny dozi bakeng sa maloetse a joalo ha e hlokahale.

Nakong ea tsamaiso, lethal dose la cefepime 50 mg / kg ea letlalo ka lilemo tse 12 e ne e se ntho e eketsehang; letlalo la lilemo tse 8.

Klіnіchnі litsobotsi.

Ts'oaetso, ka lebaka la ho ts'oenyeha hoa litlolo tsa lithethefatsi:

- litheko tsa dichalny, ho kenyeletsa pneumonia, bronchitis,

- Shkіri le pidshkіrno klіtkovini,

- Іntraabdomіnalі інфекції, ho kenyelletsa palo ea peritonitis le інфекції жовчовивідних хлавів,

Empiric kalafya вvorich iz iz neutropenichnoy garyachkoy.

Thibelo ea ts'ebetso ea tšohanyetso setsing sa bophelo sa kahare.

- Інфекції secchivividnyh, ho ekelletsa ho pyonephritis,

- tlhahisoleseling shkіri le pidshkіrno klіtkovini,

- - empirical tiba ориvorich iz ot neutropenichesky hotachka,

Khokahano le li-tab tsa bohlokoa ka ho fetisisa 'me u bone ho fapanyetsana lintho.

Zastosovuchi tekanyetso e phahameng ea aminoglycosides hang-hang le Likesky trick Extentsef, ka tlhompho e thellang ts'ebetso ea li-nickels ka monyetla oa nephrotoxicity le ototoxicity ea aminoglycoside lithibela-mafu. Nephrotoxicity e ile ea bontšoa bakeng sa stasis ea nako e ts'oanang ea cephalosporins e nang le diuretics, joalo ka furosemide.

Keketseho ea extentsef 1 ho isa ho 40 mg / ml ka melemo e joalo ea batsoali: 0,9% sodium chloride chloride bakeng sa 5%, tsoekere ea 10% tsoekere bakeng sa 6%, 6% sodium chloride bakeng sa 5%, 5% glucose le 0,9% sodium chloride bakeng sa ho inoculation, liteko tsa Ringer bakeng sa lactate le 5% glucose bakeng sa inoculation.

U ke ke ua fana ka litlhare kapele ka lithethefatsi tse hlokahalang, u reke lithethefatsi tse eketsehileng (hammoho le lithibela-mafu tse sebetsang hantle tsa b-lactam), u se ke oa potlakela ho fana ka metronidazole, vancomycin, sulfate le acid e mosa. Nakong ea ho khethoa ha lithethefatsi Extentsef le lithethefatsi tse behiloeng, kenya motsoako o thibelang likokoana-hloko oa letlalo.

E kenelletse ka lebaka la liteko tsa laboratori.

Kotsi ea nako ea khefu e ka lebisa ho hibnopositive reaction ea glucose moo boteng ba Benedict bo hohelang. Ho kgothaletswa ho etsa liteko tsa tsoekere, ho ipapisitse le enzymatic reaction ea glucose oxidation.

E na le zastosuvannya.

Bakeng sa bakuli ba kotsing e kholo ea ts'oaetso e kholo (mohlala, ho bakuli le bana, ba fetisitsoe phetisetso ea boko ba namane ka ts'ebetso e fokotsehileng, mme ho bontšoa ts'ebetso e fokolang feela bakeng sa sena).

Ho hlile hoa hlokahala ho khetholla ba hlahileng pejana ho bokuli ba mofuta o seng sephiring oa hypertrophy ho cefepime, cephalosporini, penicillin, le lithethefatsi tse thibelang likokoana-hloko. Li-antibiotic varto ho keteka ka tlhokomelo bohle re rorisa iz ho ba mofuta ofe kapa ofe oa allergy, haholo-holo litokisetsong tsa lithethefatsi. Haeba ho na le karabelo e itseng, moriana o lokela ho lokisoa. Litla-morao tse tebileng tsa mofuta o sa rutehang oa hyperpathy li ka ba teng ho adrenaline le mefuta e tlase ea kalafo.

Zastosovuvati le poloko ea bakuli іz ho ts'oaroa ha pampitšana ea joang (e patiloeng nalaneng), haholoholo lipalo.

Tabeng ea stasis, hoo e batlang e le lithibela-mafu kaofela tsa mofuta o fapaneng oa pseudomembranous colitis li batla li fapane ka ho feletseng. Ho bohlokoa hore ho bohlokoa ho boloka tlhokomeliso ea methapo le tlhokahalo ea ts'ebeliso ea moriana. Clostridium Hardile, "sesosa se ka sehloohong sa setereke sa lithibela-mafu. Bakeng sa ho khetholla lefu la pseudomembranous colitis, ho hlokahala hore ho kenelle maeto a phekolo. Pseudomembranous colitis ea mabatooa a thata a ka hlaha ha ho hlophisoa ho lokisitsoe. Ho vipadok, palo ea batho ba nang le khotso le mehato e thata ka ho fetisisa ba hloka ho shebisisa Clostridium Hardile.

Bakeng sa bakuli ba nang le ts'ebetso ea ts'ebetso e sa sebetseng (clearance creatinine ≤ 60 ml / hv), tekanyo ea cefepime e lokela ho lokisoa ka ho lefella lebelo le phahameng la lithethefatsi. Ho feta matsatsing ao, ha ho e-na le litekanyetso tsa molumo o makatsang oa bakuli ba nang le khaello ea lithethefatsi, ba ka emisa ts'ebetso ea nirk, hape re ka eketsa tlhahiso ea bona. Ka tekanyetso e sireletsehileng e sirelletsang ea ts'ebetso, ho fokotsa ts'ebetso ea mohato ka mohato, botebo ba ts'oaetso le botebo ba methapo ea methapo e thibelang likokoana-hloko. Ts'ebetsong ea ho shebella ka mor'a ho rekisa, lithethefatsi li khaolitse ho ba le likotsi tse mpe, li fetohile tšokelo bophelong, kapa lits'oants'o tse bolaeang: encephalopathy (ho senyeha ha kahlolo, ho lahleheloa ke tsebo, ho hloka tlhokomelo) Boholo ba li-vipadas bo sirelitsoe ke bakuli ba nang le ts'ebetso e sa sebetseng ea nirok, joalo ka litekanyetso tsa dosefim tsa cefepim, empa ho khothalletsoa hore li abeloe bocha. Liphetoho tse matla tsa Inkoli li ile tsa hlahlojoa moketeng, litekanyetso tsa yakimiruyut, scorched urahuvannyam funktsії nirok. Maemong a mangata, matšoao a nephrotooticity a ne a amahanngoa le li -wwwows, mme ho ne ho se na matšoao a ho omella le / kapa ho khaotsa ha hemodialysis.

Ha ho na tlhokahalo ea ntlafatso haeba ho na le bopaki bo fokolang ba ho emisa mollo haeba ho na le keketseho ea tšoaetso ea baktheria nakong e tlang. Consvale congestion cefepіmu (lithibela-mafu tsa yak іshih) e ka tlisa kholo kholisong. Hoa hlokahala ho tsamaisa mokhoa o pheta-phetoang ho patsenta. Nakong ea nts'etsopele ea bonohe, o hloka ho phela ka liketelo tsa hau tsa morao-rao.

Bagato cephalosporins, ho kenyelletsa le cefepim, e amana le ts'ebetso e fokotsehileng ea prothrombin.Pele o hlophisa sehlopha, o hloka ho kenya bakuli ka mesebetsi e robehileng ea setofo, empa bashemane, bana, bana baa korotla, hape, ba fetile thutong e sa reng letho ea kalafo ea antimicrobial. Hoa hlokahala ho laola prothrombin ho bakuli ba nang le sehlopha le haeba ho na le moelelo o hlokahalang oa K. K.

Nakong ea pherekano, cefepim e ka ba ntle empa e se ntle ho tsoa tlhahlobo e tobileng ea Coombs. Nakong ea ts'ebetso ea hematologic kapa tšelo ea mali, ha mofuta oa mali o bonts'itsoeng o etsoa ka tsela e fetelletseng, haeba tlhahlobo ea antiglobulin e etsoa, ​​empa tlhahlobo ea Coombs e sebelisoa bakeng sa batho ba bacha, bo-mme ba hlakotsoe lithibela-mafu tsa cephalosporins, re ile ra khona ho fumana sephetho se setle sa liteko.

Bulo o ile a holisoa, e le hore moriana oa L-arginine o sebelisang glucose metabolism hang ka nako e ts'oanang maling le litekanyetso tse tsitsitseng, ka makhetlo a 33 tekanyo e kholo e khothalelitsoeng ea cefepime. Liphetho litekanyetso tse tlase tse tlase tsa selemo se secha.

Ha zasosuvannі lіdokainu yak rozniknika slіd vrakhovuvati іnformatsіy ka bezpeki lіdokainu.

Zastosuvannya ka nako ea vaginosti abo selemo sa matsoele.

Matla a lekaneng le taolo e ntle ea pheletso ea karolo ea bophelo ba basali e ne e sa etsoe, ka hona, Extent e ka ba le lipontšo tsa lilemo tse lekanang le tsa mme, haeba moriri o le bobebe hore mme a abise boteng ba lesea.

Cefepim ka shaoara e nyane, ho kenella ha sefuba ho lebeseng, eo ke hora ea ho tseba selemo sa Extentsef sa matsoele.

Bophelo bo botle ho amohela lebelo la karabelo ha likoloi tsa makoloi tsa cheruvannі le mekhoa e meng kaofela.

Netefatsa ho cefepim bakeng sa lebelo la karabelo haeba ho na le sephethephethe sa koloi ea cheruvanny, hobane liroboto li ne li sa qhoebeshane le mekhoa ea morao-rao, leha ho le joalo, li nkile moena ka tlhompho, empa kamora hora ke khona ho sebelisa sethethefatsi, ha ke khone ho arabela ka lehlakoreng la tsamaiso ea methapo.

Sposib zososuvannya that dozi.

Tekanyo ea Daiayna bakeng sa pele ho nako e ba 1 g, e tsamaisoang kahare kapa kahare nako e telele ea lilemo tse 12. Tabaayna triviality ea polelo - Matsatsi a 7-10, tšoaetso e boima e ka nka polelo e sa reng letho.

Dosuvannya i shlyakh uvdennya var_yuyut ka mokhoa o ts'oarehang o ela hloko microorganism, tlhokomelo ea bophelo bo botle, boemo ba ts'oaetso ea tšoaetso, hammoho le kampo e sebetsang ea nikor. Litlhahiso tsa tekanyetso e phahameng ea lithethefatsi Extentsef bakeng sa ho kenella ho feta tekano tafoleng.

Meroalo e bonolo le e mahareng ea sekhahla

500 mg - 1 g ka hare, empa kahare 'ulcer

Burdensнші інфекції meroalo e bobebe le e mahareng

1 g ka hare, empa ka hare