Ente tsa Kokarnit: taelo
Kokarnit ea lithethefatsi e ipapisitse le livithamini le li-coenzymes, tseo ka tsona mesebetsi ea metabolic liseleng le liseleng tsa 'mele li ntlafatsoang. Moriana o na le litlamorao tse kang neurometabolic le analgesic, hape o na le phello e ntle tikolohong ea limela tse nang le maikutlo. Kokarnit ea lithethefatsi ke eng, hammoho le likarolo tsa tšebeliso ea eona.
Ketso ea pharmacological ea moriana
Kokarnit ea lithethefatsi e hlahisoa ka sebopeho sa lintho tse rarahaneng tsa metabolic le livithamini tsa lihlopha tse fapaneng. Sebopeho sa lithethefatsi Kokarnit se na le ntho e kang nicotinamide, e rarahaneng ea vithamine eo sebopeho sa eona se haufi haholo le nicotinic acid. Ka sena, ho tla hlaha liketso tse latelang:
- Ts'ebetso ea mesebetsi ea redox ka har'a lisele tsa motho le lisele.
- E fetoha ntlafatso ea metabolism ea naetrojene.
- Tekanyo ea lipoprotein ea atherogenic e fumanehang maling e ea fokotseha.
- Motsoako o khahlanong le allergic oa thehoa.
Cocarboxylase e fumanehang ka har'a moriana oa litlatse Kokarnit ke coenzyme e tsoang sehlopheng sa li-enzyme tse hlophisitsoeng 'meleng. Li-enzyme tse joalo li bohlokoa ts'ebetsong ea lik'habohaedreite le metabolism ea mafura, 'me ka holim'a moo, ntlafatsa tsoekere ea tsoekere, etsa hore ho tsamaisoa ha likarolo tse molemo le ho fepa lisele tsa motho. Haeba enzyme e joalo 'meleng joalo ka cocarboxylase ha e ea lekana, joale ho na le keketseho e matla tekong ea acid le lactate maling. Sena se lebisa nts'etsopele ea liphokotso tsa tekano ea acid-base.
Cyanocobalamin e hlahisoa e le limatlafatsi tse nang le cobalt. Bakeng sa ts'ebetso e tloaelehileng ea 'mele oa motho, ntho ena ea trace e tlameha. Mesebetsi ea eona e meholo e kenyelletsa:
- Ho nka karolo ka mafolofolo ho protheine, mafura le carbohydrate metabolism. Ntle le moo, motsoako oa sekhahla o potlakisa ts'ebetso ea nchafatso liseleng.
- E theola sesupo sa k'holeseterole maling, hape e tlosa ho bokellana ho hoholo ha lisele tsa mafura seleng.
- E na le tšusumetso e ntle tšebetsong ea ts'ebetso ea sebete le tsamaiso ea methapo.
Ntho e 'ngoe ea bohlokoa e etsang Kokarnit ke disodium adenosine. Mefuta ea eona e nepahetseng e kenyelletsa:
- Ho theola khatello ea mali.
- E eketsa methapo ea mali.
- Fokotsa ho hlaha hoa arrhythmias.
Kokarnit ea lithethefatsi e fumaneha feela e le ente ea liente. E na le 'mala o phofo oa' mala o pinki, o lokelang ho qhibiliha pele o kenoa. The kit e tsamaea le solvent, hammoho le litaelo tsa tšebeliso. Karolo e ruileng ea moriana e u lumella ho fana ka phello ea kalafo e matla ho motho ea nang le mafu a fapaneng. Ke mafu afe a sebelisoang kalafo, re ithuta ho feta.
Matšoao a ho sebelisoa
Li-ente tsa Kokarnit li laetsoe hore li sebelisoe boteng ba maloetse a latelang:
- Lisele tsa methapo ea tlhaho e sa foleng.
- Ho holofala ha mesifa.
- Bohloko ba mesifa.
- Letšoao la bohloko, le hlahisoang ka lebaka la khatello ea methapo.
- Bohloko bo tlase ba morao.
- Lefu la pelo.
- Lits'ebetso tsa ho ruruha tse kenang ka har'a mesifa ea pelo.
Boteng ba e 'ngoe ea maloetse a kaholimo, u ka sebelisa ts'ebeliso ea lithethefatsi Kokarnit, empa feela kamora ho khethoa ha setsebi kapa ho buisana le eena. O ka fana ka ente ea Kokarnit lapeng, haeba ka nako e ts'oanang ho na le boemo bo lekaneng ba tsebo le tloaelo bakeng sa ts'ebetso.
Maemong a mang ts'ebeliso ea Cocarnit e patiloe
Taelo ea ts'ebeliso ea Kokarnit e bolela hore ho kenella ka ente ea thibelo ho thibetsoe ka tieo maemong ao mokuli a nang le mafu a latelang:
- ho nyekeloa ke pelo
- ho fokotseha ha sekhahla sa pelo,
- myocardial infarction
- stroke
- asthma ea lefu la bronchial,
- tumor neoplasms,
- liso tsa ka mpeng,
- lefu la tsoekere
Ts'ebeliso ea moriana e emisitsoe haeba mokuli a e-na le karabelo e ntle ea 'mele ho motsoako ofe kapa ofe oa lithethefatsi. Ho kenyelletsa nts'etsopele ea maikutlo a ho kulisa, ho hlokahala tlhahlobo ea pele. Ntle le moo, lingaka ha li khothaletse ho batla thuso ho sena lithethefatsi bakeng sa basali nakong ea ho beleha ngoana, le nakong ea ho anyesa. Haeba ho na le tlhoko ea ho sebelisa moriana nakong ea lebone, lesea le lokela ho fetisetsoa ho nakoana ho feptjoa.
Litšobotsi tsa tšebeliso ea moriana
Sebopeho sa lithethefatsi Kokarnit se kenyelletsa karolo e joalo ka lidocaine. Pele o sebelisa tšebeliso ea meriana, ho hlokahala ho etsa bonnete ba hore mokuli ha a kulisoe ke letho. Haeba karabelo ea sebopeho sa moriana e le e ntle, kenyelletso ea moriana e lokela ho qheleloa ka thoko.
Ho bohlokoa ho tseba! Haeba ho kula ho hlaha, ho bonahala matšoao a kang ho ruruha, bofubelu ba letlalo, lekhopho, ho phefumoloha ka potlako le ho senyeha ha bophelo bo botle. Kotsi ea lipontšo tsa mzioa ke hore moriana o ka baka ts'oabo ea anaphylactic, ka kholo ea motho ea ka shoa.
Moriana ona o etselitsoe feela tsamaiso ea methapo. Pele o fana ka moriana, o lokela ho bula ampoule le solvent, ebe o theola palo e hlokahalang ka syringe, ebe o e kenyelletsa le motsoako o omileng oa moriana. Kamora hore tharollo e eketsoe ka botlolong ka motsoako o omileng, ha ho hlokahale hore o tlose syringe ka nale ka sekontiri. Sebopeho sa moriana se lokela ho tsoakoa ka botlalo ho fihlela ho fumanoa tumellano e kopanetsoeng, ebe e kenngoa ka syringe.
Pele o kenya moriana ka har'a mesifa, sebaka sa ente se lokela ho phekoloa ka joala. Ente e ka beoa ho gluteus, empa nale e telele e ea hlokahala ho fihlela likhoele tsa mesifa ka kotloloho. Setlhare se kenngoa butle butle ho sa qopeho sebopeho sa compaction boteng ba lithane tsa adipose.
Sekhahla sa ts'ebetso ea ts'ebetso ea moriana ha sea lokela ho feta 4 ml, ke hore, li-ampoules tse peli. Nako ea ho felisoa ha matšoao a bohloko e ka nka matsatsi a 9, empa ha e sa le eo. Sebakeng ka seng, o hloka ho ikopanya le setsebi se tla u fa tlhahlobo e itseng ea ts'ebeliso ea moriana o joalo. Haeba sesebelisoa se sa kenye letsoho ho hlaha ha litekanyetso tse ntle, joale ngaka e etsa qeto ea ho khethoa ha lithethefatsi tse matla ho feta.
Tekanyetso e feteletseng le litlamorao
Moetsi ha a khothalletse ho tsamaisa lithethefatsi ka tekanyo e kholo ho feta e boletsoeng litaelong. Phekolo e ngata e ke keng ea ntlafatsa boemo ba mokuli. 'Me e tla kenya letsoho ho hlaha ha phello ea matla a ho feta tekano. Matšoao a lefu le feteletseng a bakoa ke nts'etsopele ea matšoao a latelang:
- ho ba teng ha hlooho ea hlooho
- ho tsekela
- mokhathala,
- ho lahleheloa ke kelello
- pulmonary edema,
- asphyxia
- ho theola khatello ea mali
- ho fokotseha hoa pono,
- coma.
Haeba, kamora ts'ebetso ea ts'ebetso ea meriana, e 'ngoe ea matšoao a ka holimo e etsahala, ho bohlokoa hore o khaotse ho sebelisa Cocarnit mme o letse tlhokomelo ea tšohanyetso. Motsoako oa meriana e mengata ea Kokarnit ha o eo, ka hona, thuso e nepahetseng ho mokuli e tla fanoa ho latela matšoao a hlahang.
Litsela tsa bohlokoa tsa ho sebelisa moriana
Kamora ho lokisa moriana, ente e lokela ho qhekelloa hanghang. Ho boloka nako e telele meriana e lokiselitsoeng ho fokotsa ts'ebetso ea phello e ntle. Kamora ho lokisa ente, 'mala oa eona o lokela ho ba khubelu. Haeba, kamora ho lokisa, 'mala oa ente o sa tsamaisane le tloaelo, tšebeliso ea sehlahisoa e thibetsoe ka thata. Ke mosebeletsi ea tšoanelehang feela ea hlokahalang ho fana ka meriana, empa haeba ho na le tsebo e nepahetseng ho tsoa phihlelong, ho hlahisoa ha moriana ho lumelloa ho motho ntle le thuto ea bongaka (moena kapa motsoalle oa mokuli).
Pele u qala ho sebelisa moriana, ho hlokahala hore o hlatse letlalo sebakeng sa ente. Ka hlokolosi e kholo, ho hlokahala ho sebelisa lithethefatsi maemong a joalo:
- ho fokotseha ha sekhahla sa pelo,
- mafu a tsamaiso ea matšoafo
- nako ea ts'ebetso
- bokhoba ba joala
- mosebetsi o sa sebetseng oa liphio le sebete,
- khatello ea kelello ea methapo.
Tšebeliso ea lithethefatsi maemong afe kapa afe a kaholimo e ka baka litlamorao tse mpe. Haeba u sebelisa moriana ona nako e telele, joale tsoelo-pele ea mafu a sebete a sa foleng ha e qheleloe ka thoko. Ho kenyelletsa ho thehwa ha mofuta ona oa khatello, ha tšebeliso ea lithethefatsi e laetsoe matsatsi a 9, lijo tse ntlafalitsoeng methionine li lokela ho kenngoa lijong.
Ha kalafo e etsoa ka thuso ea Kokarnit, matšoao a latelang a bohlokoa a lokela ho beoa leihlo ntle le ho hloleha:
- Bophahamo ba glucose.
- Potasiamo le magnesium 'meleng.
- Lactate maling.
Bakeng sa barati ba kofi, o lokela ho fokotsa bongata ba tšebeliso ea eona nakong ea ts'ebeliso ea lithethefatsi ka bonyane.
Ho sebelisana le meriana e meng
Bohlokoa bo boholo bo lokela ho fanoa nthong e kang ho sebelisana le lithethefatsi tse ling. Moetsi le litsebi ha ba khothaletse tšebeliso ea Kokarnit le mefuta e meng ea lithethefatsi, kaha sena se kenya letsoho ho li-pathologies tse latelang:
- Kotsi e eketsehileng ea hyperkalemia. Psychology e joalo e ba teng haeba moriana o kopaneng o nooa le diuretics.
- Ts'ebeliso e rarahaneng ea li-glycosides e thusa ho hlaha hoa li-pathologies, hammoho le matšoao a lehlakoreng la tsamaiso ea methapo ea pelo.
- Fokotsa palo ea lidocaine ho plasma ea mali ka tšebeliso e kopaneng ea Petidine le Quinidine.
- Ka tšebeliso e kopaneng ea morphine, ho ka khonahala ho tsosa ts'ebetso ea phefumoloho.
- Kotsi e eketsehileng ea ho tsoa mali haeba e kopantsoe le li-anticoagulants.
- Phekolo e kopaneng le inhibitors e thusa khatello ea mali e tlase.
- U ke ke ua sebelisa Cocarnit hammoho le Xanthinol, kaha e qetellang e fokotsa katleho ea ea pele.
Ho bohlokoa ho tseba! Pele o fana ka moriana, o lokela ho ikopanya le setsebi se tla u joetsa tlhokahalo ea tšebeliso ea sona.
Litšenyehelo le likarolo tsa polokelo
U ka reka lithethefatsi Kokarnit feela ka sepheo se nepahetseng ho tsoa ho ngaka ea hau. Litsenyehelo tsa moriana ka liente ke li-ruble tse 720 bakeng sa li-ampoules tse 3. Setlhare se hlahisoa ke baetsi ba 'maloa, kahoo leano la litheko le ka fapana haholo. E le hore u se ke oa oela fake, o lokela ho reka meriana feela litlhare tsa meriana tse netefalitsoeng.
Boloka moriana o le feela sebakeng se lefifi moo ho fihlellang bana. Ho boloka lithethefatsi ho sa sebetse hantle ho tla etsa hore e be tse sa tloaelehang, kamora ts'ebeliso ea eona e thibetsoe ka thata. Hangata, bophelo ba sefuba sa lithethefatsi ho tloha ka letsatsi la tlhahiso ke lilemo tse 3 tse nang le polokelo e nepahetseng. Ha u reka moriana, etsa bonnete ba hore u ela hloko letsatsi la tokollo. Kamora letsatsi la ho felloa ke nako, lithethefatsi li ka lahloa.
Ho bohlokoa ho tseba! Ts'ebeliso ea Cocarnitus e kopantsoe le bana ba lilemo tse ka tlase ho 18.
Qetellong, ho lokela ho hlokomeloa hore lithethefatsi li na le li-analogues, kahoo haeba li sa hlahe ka har'a khemisi ea Kokarnit, joale e ka nkeloa sebaka ke: Cardonate, Actovegin, Vitaxone, Milgamma.
Fomati ea ho lokolla, ho kenya lithethefatsi le sebopeho sa eona
Kokarnit e rekisoa ka mofuta ofe? Taelo e tlaleha hore moriana ona o ka mokhoa oa lyophilisate bakeng sa ho hlophisoa ha tharollo, hammoho le solvent (lidocaine) ho ampoules.
Sebopeho sa moemeli ona se kenyelletsa nicotinamide, cocarboxylase, cyanocobalamin le adenosine triphosphate. Ha ho sebelisoa likarolo tse ling, glycine, propyl parahydroxybenzoate le methyl parahydroxybenzoate.
Litšobotsi tsa Pharmacodynamic
Sesebelisoa seo re ithutang sona ke sefe? Taeo e reng ka eena? Kokarnit ke mofuta oa livithamine le lintho tse amang metabolism. E na le phello ea neurometabolic le analgesic, hape e ama le karolo ea tlhaho ea limela.
Ho sebetsa ha moriana ona ho teng ka lebaka la sebopeho sa ona. Nahana ka likarolo tsa ntho ka ngoe ka botlalo.
Nicotinamide e ama hantle carbohydrate le metabolism ea naetrojene, e nka karolo lits'ebetsong tsa redox hape e khothaletsa ho tsamaisoa ha ATP liseleng. Hape, ntho ena e na le thepa e hohelang. Ntlheng ena, e sebetsa hantle haholo bakeng sa mathata a neuropsychiatric, khatello ea maikutlo, ho tšoenyeha le ho fokotsa tlhokomelo.
Cocarboxylase ke coenzyme e phethang karolo e kholo ho metabolism ea carbohydrate, e ama motsoako oa li-anemic acid, e ntlafatsa trophism ea tishu, lipids le liprotheine, hape e khothaletsa ho kenngoa ha tsoekere.
Adenosine triphosphate e tsoa ho adenosine. Karolo ena e phahamisa mekhoa ea metabolic. Ke karolo e ka sehloohong ea matla ea lisele. Ka lefu la coronary, khaello ea matla ea hlaha, e ka fokotsoang ka lebaka la adenosine triphosphate. Ho tsamaisoa ha eona lisele ho etsahala ka lebaka la nicotinamide. Adenosine triphosphate e khona ho hlahisa litla-morao tsa antiarrhythmic, hypotensive le vasodilating.
Ha e le cyanocobalamin, e hlophisa le ho bokella liprotheine, e kenya ts'ebetsong metabolism ea lik'habohaedreite le mafura. Liphetho tsa ketso ena ke ho fokotseha ha cholesterol, hammoho le thibelo ea hepatosis e mafura.
Hape ho lokela ho hopoloa hore cyanocobalamin e eketsa bokhoni ba ho nchafatsa lisele, tse hlokahalang bakeng sa ts'ebetso ea litho tse etsang mali, sebete le tsamaiso ea methapo.
Ke mafu afe a laetsoeng meriana e kang Kokarnit? Litaelo tsa tšebeliso (liente li lokela ho etsoa feela ke setsebi sa bophelo bo botle) se bonts'a hore matšoao a sesebelisoa sena ke:
- neuritis
- neuralgia ea mefuta e fapaneng,
- sciatica, lumbago, sciatica,
- myalgia, tendonitis, bursitis,
- neuropathy (ho kenyeletsa lefu la tsoekere),
- myocardiopathy, lefu la pelo la ischemic, myocarditis.
Hape ho lokela ho boleloa hore nakong ea kemolo sethethefatsi sena se sebelisoa feela haeba molemo ho 'm'a oa ka moso o phahame haholo ho feta kotsi ho lesea.
Contraindication
Ha ua lokela ho fana ka litlhare "Kokarnit"? Taelo e re moriana ona o tšoaetsitsoe:
- hypersensitivity
- mofuta o matla oa khatello ea methapo ea methapo, hammoho le hypotension,
- erythrocytosis, erythremia,
- psoriasis
- Ho nyekeloa ke pelo ho sa sebetseng hantle le ho nyekeloa ke pelo haholo,
- myocardial infarction nakong e bohloko haholo.
Ho ke ke ha boleloa hore moriana o boletsoeng o khothalletsoa ka hloko bakeng sa batho ba nang le gastritis, ulcer, gout le senya ea sebete. Ha ho na data ea ts'ebeliso ea meriana ena ho bana ba banyenyane.
Ntle le moo, ha ho fanoa ka moriana o boletsoeng, litlatsetso tse latelang bakeng sa solvent ka mokhoa oa 0,5% lidocaine li lokela ho tsotelloa: Adams-Stokes syndrome, sinus node fokola syndrome, angina pectoris, Wolf-Parkinson-White syndrome ho se sebetse hantle ha renal le porphyria.
Ente tsa Kokarnit: taelo
Litlhahlobo mabapi le sesebelisoa sena li tla hlalosoa ka tlase.
Ho latela litaelo, sethethefatsi sena se tlameha ho fanoa ka methapo e le 'ngoe ka makhetlo a 1 kapa a mabeli ka letsatsi. Liente li etsoa ka lithuto. Nako ea bona e itšetlehile ka ho teba ha lefu lena.
Tharollo ea lithethefatsi e sebelisoa hang ka mor'a ho itokisa. Ho feta moo, e lokela ho ba e khubelu. Haeba mmala o sa fetoha, joale tšebeliso ea lithethefatsi e thibetsoe.
U sebelisa moriana oa Kokarnit, thuto ea eona e kentsoe ka har'a karete ea likarete, lisele tse khubelu tsa mali le liplatelete, nako ea ho ikatisa, uric acid, bilirubin le transaminase li lokela ho betoa leihlo khafetsa.
Litlamorao
Litlamorao ke Life kamora ho sebelisa Kokarnit? Litaelo tsa tšebeliso li bonts'a hore lithethefatsi tsena li ka baka:
- tachycardia
- hlooho e bohloko
- urticaria
- bofokoli
- mofufutso
- ho tsekela
- makhopho a letlalo,
- anaphylactic makala,
- ho hlohlona
- lets'ollo
- peripheral vascular thrombosis,
- pulmonary edema.
Hape ho lokela ho hopoloa hore bakuli ba nang le hypersensitivity pele ho kenyelletsoa ha moriana ba etsa tlhahlobo ea methapo.
Ho sebelisa lithethefatsi tse ngata
Ho tla etsahalang ka meriana e mengata e mengata ea Kokarnit? Litaelo tsa ho sebelisoa (liente li lokela ho fanoa ke setsebi feela) li re haeba moriana o nooa ka phoso ka tšohanyetso, ho ka hlaha lintho tse kotsi, tse hlahisoang ke ho fufuleloa ha letlalo, ho hlohlona, ho nyekeloa ke pelo, hlooho e opang, ho hlatsa kapa ho otla ha pelo.
Bakeng sa tahi e sa foleng ea lithethefatsi, keketseho ea boemo ba uric acid le tsoekere, hammoho le ponahalo ea liso tsa kahare ho duodenum, ke tšobotsi.
Ho sebelisana le meriana e meng
Nka sebelisa moriana oa li-Kokarnit (liente) ka lithethefatsi tse ling? Taeo e tlaleha hore cocarboxylase, eo e leng karolo ea lithethefatsi, e khona ho ntlafatsa phello ea pelo le pelo ea pelo glycosides.
Ha e le nicotinamide, e hlahisa thepa ea anticonvulsant ea lithethefatsi tsa antiepileptic (mohlala, Diazepam, Carbamazepine, Valproate).
Adenosine triphosphate hammoho le diuretics tsa potasium-sparing, litokisetso tsa potasiamo le li-inhibitors tsa ACE li eketsa kotsi ea hyperkalemia. E boetse e ntlafatsa ts'ebetso (antianginal) ea li-nitrate le beta-blockers.
Ha u sebelisa moriana o na le dipyridamole, phello ea eona e ntlafatsang.
Xanthinol nicotinate e fokotsa ho sebetsa ha adenosine triphosphate, 'me Carbamazepine, ho fapana le moo, e matlafatsa sephetho sa eona.
Mmoho le "Theophylline" le antagonism ea caffeine li bonahatsoa.
Ho kenngoa ha moriana ho fokotsoa ke litokisetso tsa potasiamo, cyanocobalamin aminoglycosides, lithethefatsi tsa antiepileptic, salicylates le Colchicine.
Ho amoheloa ha cyanocobalamin ho fokotsehile ha ho ntse ho nkuoa "Polymyxin", "Kanamycin", "Neomatsin" le "Tetracycline."
Cyanocobalamin ha e lumellane le ascorbic acid, Riboflavin, Pyridoxine le matsoai a tšepe e boima.
Mekhoa ea ho thibela pelehi ea molomo e fokotsa khatello ea cyanocobalamin maling.
Litšenyehelo le litekanyetso
Lithethefatsi "Kokarnit" ke bokae? Litaelo tsa ho sebelisoa ha li na ho fana ka karabo ea potso. U ka e fumana feela ka k'hemisteng. E le molao, theko ea sehlahisoa sena bakeng sa li-ampoules tse tharo e fapana pakeng tsa li-ruble tse 120-150.
Ke eng e ka nkang tharollo ea metaboliki ea Kokarnit? Litaelo, litekolo li re ha ho na liathomo tsa moriana ona. Ho e khutlisa ka mokhoa o tšoanang, o hloka ho etela ngaka (hangata ba khothaletsa Ismizhen, Venohepanol, Threw, Orcipol, Sterillium, Dioflan, Collomac, Chondrosamine, Endofalk, " Secnidox ").
Joale u tseba molao-motheo oa ts'ebeliso ea lithethefatsi "Kokarnit." Litaelo, analog ea meriana ena e hlahisitsoe ka holimo.
Hangata, sesebelisoa sena se sebelisoa ho ts'ebetso ea methapo, pelo le pelo. Litsebi li hlokometse hore moriana ona o khona ho fokotsa palo ea maqeba a ho senya, hammoho le ho tlosa bohloko ba 'metso ea vertebrogenic.
Hape ho lokela ho hlokomeloa hore moriana o boletsoeng o ipakile kalafo e rarahaneng ea bakuli ba nang le discogenic lumbosacral radiculitis. Maemong ana, lithethefatsi li tlameha ho sebelisoa ka mokhoa o ts'oanang ka makhetlo a 2 ml ka letsatsi bakeng sa libeke tse 2-3.
Bakuli ha baa ka ba tlaleha litla-morao ka lithethefatsi tsena.
Sokolla foromo le sebopeho
Kokarnit e fumaneha ka sebopeho sa lyophilizate bakeng sa ho hlophisoa ha tharollo ea tsamaiso ea methapo (i / m): boima ba mmala o pinki, kamora ho khutlisetsa tharollo e hlakileng ea pinki (187.125 mg e ngoe le e ngoe ka khalase e lefifi ea khalase, li-ampoules tse 3 le li-lyophilisate le li-ampoules tse 3 ka paketeng ea blister. 2 ml e nang le solvent, ka paketeng e le 'ngoe ea karete ea karete.
1 ampoule e na le:
- metsoako e sebetsang: cocarboxylase - 50 mg, cyanocobalamin - 0.5 mg, triphosadenine disodium trihydrate - 10 mg, nicotinamide - 20 mg,
- likarolo tse thusang: propyl parahydroxybenzoate, glycine, methyl parahydroxybenzoate.
Solvent ke lidocaine hydrochloride, metsi a ente.
Mofumahali
Ketso ea Kokarnit e bakoa ke thepa ea motsoako o khethiloeng oa lintho tse sebetsang.
Cocarboxylase ke coenzyme e thehiloeng ho thiamine (vithamine B1) Ke karolo ea "enboxme" ea carboxylase, e thusang "carboxylation" le "decarboxylation" ea alpha-keto acid. E ama ka tsela e sa tobang syntheine ea li-nucleic acid, lipids le liprotheine. E khothalletsa ho monya ha tsoekere, e fokotsa litaba tsa acid le lypicvic 'meleng, e ntlafatse trophism ea lisele tsa methapo.
Trifosadenin e tsoa ho adenosine, e na le metabolic, antiarrhythmic, hypotensive, vasodilating effect. Tlas'a tšusumetso ea ATP (adenosine triphosphoric acid), mesifa e boreleli e nchafatsoa, khatello ea mali (BP) ea fokotseha, mme litšusumetso tsa methapo lia ntlafala. E thusa ho eketsa metabolism le phepelo ea matla ea lisele. Matla a vasodilating a bonahala ho kenyelletsa ho methalo ea methapo ea methapo le methapo.
Cyanocobalamin - Vitamin B12, eo kamora ho kena 'meleng e fetoha mefuta e' meli ea coenzyme: 5-deoxyadenosyl cobalamin le methyl cobalamin. Methylcobalamin e bapala karolo ea bohlokoa phetohong ea mantlha ea metabolic ea methapo ea purine le pyrimidine, mohlala, phetohong ea homocysteine ho methionine le S-adenosylmethionine. Ho haella ha vithamine karabong ena ho ka buselitsoe ke methyltetrahydrofolate acid, ka lebaka la sena ho na le tlolo ea tsamaiso ea methapo ea methapo ea methapo. 5-deoxyadenosyl cobalamin e ameha karabelong ea carbohydrate le lipid metabolism, ha e le cofactor ho isomerization ea L-methylmalonyl coenzyme A ho succinyl coenzyme A. Ho haelloa ha vithamine B12 'meleng o baka tlolo ea sebopeho sa myelin sheath ea li-neuron, ho ata ha likarohano tsa lisele tsa epithelial ka potlako le lisele tsa hematopoietic.
Nicotinamide - mofuta oa vithamine PP, e nka karolo lits'ebetsong tsa redox seleng. E laola ho phefumoloha ha lisele, ho ntlafatsa lik'habohaedreite le metabolism ea naetrojene.
Mofumahali
Kamora taolo ea batsoali, trifosadenin e kenella liseleng tsa litho. Moo, e robehile ka har'a adenosine le phosphate e sa sebetseng ha e tsoa ka matla. Lihlahisoa tsa thetso li kenyelletsoa ka mor'a moo ho sebelisa resynthesis ea ATP.
Ho kenngoa ha cocarboxylase ka tsamaiso ea i / m ho etsahala ka potlako 'meleng ka ho kenella ka har'a lisele tse ngata. Motsoako oa lihlahisoa tsa "metabolic decomposition" o hlaha haholo ka liphio.
Kamora ho tsamaisoa ha i / m, cyanocobalamin e potlaka ebile e kenella ka botlalo. Ho tsamaisoa ha eona liseleng ho etsoa ke transcobalamin I le II, tseo e li tlamang maling. 0.9% ea lethal dose e laetsoeng e hokahana le liprotheine tsa plasma. Kamora ho tsamaisoa ha i / m, khatello e phahameng maling e fihlella kamora hora e le 'ngoe. E bokelloa haholo-holo ka har'a sebete. E hloekisoa ke bile e tsoang ka sebete ho kena ka mpeng, moo e kenang hape maling. Ho felisoa ha halofo ea bophelo ke matsatsi a 500. Ts'ebetsong e tloaelehileng ea renal, 7-%% e epuoa ho tsoa liping, 'me e ka ba 50% ka mala. Tabeng ea ho senyeha ha renal, 0-7% e epolloa ke liphio, 70-100% - ke mala. Cyanocobalamin e tšela sethibela sa placental ebe e kena ka lebese la matsoele.
Ho ajoa ha nicotinamide linthong tsohle ho etsahala kapele, ntho e na le bokhoni ba ho tšela sethala sa placental le ho kenella ka lebeseng la matsoele. Ka lebaka la metabolism sebeteng, ho thehoa nicotinamide-N-methylnicotinamide. Tlhahiso ea ntho ena e hlaha ka liphio. Ho felisoa ha halofo ea bophelo ke lihora tse 1,3.
Bophahamo ba lifaele ke hoo e ka bang 60 l, botlalo ba botlalo ba plasma ea mali ke hoo e ka bang 0,6 l / min.
Litaelo tsa ts'ebeliso ea Cocarnit: mokhoa le litekanyetso
Tharollo e felileng ea moriana e etselitsoe ente ea methapo ea methapo (e kenella ka har'a mesifa ea gluteal).
Kamora ho kopanya lyophilisate le solvent, tharollo e hlahisang e lokela ho ba pinki. Haeba 'mala oa tharollo o sa lumellane, o ka se sebelisoe.
Tharollo e lokisitsoe pele ho ts'ebetso e tobileng ea lithethefatsi.
Se ke oa boloka tharollo ea litlhare e felileng!
Ngaka e fana ka maikutlo a hore na kalafo e nka nako e kae le hore na o na le khatello hakae khafetsa.
- bohloko bo boholo ba polyneuropathy: 1 ampoule 1 nako ka letsatsi, nako ea tšebeliso ea ho imolla matšoao a hlobaetsang ke matsatsi a 9,
- matšoao a bobebe a polyneuropathy: 1 ampoule 1 nako ka matsatsi a 2-3. Mofuthu oa kalafo o itšetleha ka ho teba ha lefu lena mme o ka tloha ka makhetlo a 3 ho isa ho a 9 ka nako e telele ea matsatsi a 14-16.
Tlhokahalo ea lithuto tse phetoang e khethoa ke ngaka.
Litaelo tse khethehileng
Haeba ho hlaha lintho tse bohloko, etela ngaka.
Ka mofuta o boletsoeng oa litla-morao, Kokarnit e lokela ho felisoa.
Haeba kamora matsatsi a 9 a ho sebelisa moriana ha ho na phello ea kalafo kapa ho eketsoa hoa matšoao a lefu lena, ho hlokahala hore u nahane ka khalemelo ea nako ea kalafo.
Nakong ea ts'ebeliso ea Kokarnit bakeng sa taolo e lekaneng ea lefu la tsoekere, ho hlokahala hore o fetole tekanyetso ea li-hypoglycemic agents.
Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng
Nakong ea kalafo, tlhokomelo e lokela ho nkuoa ha u etsa lintho tse ka bang kotsi. Bakuli bao Kokarnit e bakang ho tsekela, pherekano kapa mathata a mang a methapo ea kutlo ha baa lokela ho ameha ho khanna makoloi le ho sebetsa.
Ho sebelisana le lithethefatsi
Ka tšebeliso e tšoanang ea lithethefatsi Kokarnit:
- li-hypoglycemic agents tse nang le metformin li ka ama ho amoheloa ha cyanocobalamin le ho baka ho fokotseha ha karolo ea eona maling.
- riboflavin, ascorbic acid, thiamine bromide, thiamine, salate e boima ea tšepe, pyridoxine, folic acid, li-ingredient tsa mali, chloramphenicol - e ke ke ea sebelisoa ka lebaka la ho se lumellane le cyanocobalamin,
- aminoglycosides, lithethefatsi tsa antiepileptic, salicylates, colchicine, litokisetso tsa potasiamo li fokotsa ho monya cyanocobalamin,
- dipyridamole e ntlafatsa matla a eona a vasodilating le phello ea trifosadenin,
- caffeine, theophylline (lintlha tse tsoang ho eona) e ka baka ho hloka lithethefatsi ho lithethefatsi,
- tekanyetso e kholo ea "glycosides" ea pelo e ka eketsa kotsi ea litlamorao tse sa rateheng ho tsoa ho tsamaiso ea pelo,
- xanthinol nicotinate e fokotsa litlamorao tsa lithethefatsi,
- li-antihypertensives le li-sedatives, li-tranquilizer tlas'a tšusumetso ea nicotinamide li ntlafatsa phello ea tsona ea kalafo.
Likhatiso tsa Cocarnit ke Thiamine Chloride le Cocarboxylase.
Litlhahlobo mabapi le Kokarnite
Litlhahlobo tse 'maloa tsa Kokarnit li paka ts'ebetso ea lithethefatsi kalafong ea lefu la tsoekere la polyneuropathy. Bakuli ba nang le lefu la tsoekere ba ngola ka ketso e potlakileng ea moriana, ha bohloko ba leoto le radiculitis bo tloha kamora liente tse 'maloa feela. Ha ho na litletlebo tsa mamello e mpe le liketsahalo tse bohloko nakong ea kalafo.
Kaha likarolo tsa moriana li na le mefuta e mengata ea kalafo, hangata ho na le litlhahlobo tse ntle tsa bakuli ba sebelisang lithethefatsi bakeng sa maloetse a kang osteochondrosis, methapo ea methapo ea pelo, neuralgia ea mokokotlo oa lumbosacral. Ntle le phello ea bohlokoa ea li-analgesic, ntlafatso ntlafatsong e akaretsang le boemo bo sebetsang ba sebete bo hlokomelehile. Lithethefatsi li theola khatello ea mali le cholesterol, li na le phello ea antiarrhythmic le vasodilator.
Cocarnit ka ampoules: likarolo tsa moriana
Kokarnit e bolela - liente ka ampoules. E fumaneha feela ka sebopeho sa lyophilisate sa ente. Ha e fumanehe ho letlapa, ho emisoa le mefuta e meng. E na le livithamini tsa metabolic le lintho tse tlatsetsang ho potlakiseng ha metabolism.
Ketso ea moriana e kenyelletsa:
- ts'ebetso ea lits'ebetso tsa oxidative 'meleng,
- ntlafatso ea metabolite ea naetrojene,
- litlamorao
- fokotseha ha lipoprotein tsa atherogenic maling,
- vasodilation,
Setlhare se shebahala joaloka phofo e pinki, bakeng sa ente e tla hloka ho hlapolloa. Solvent ea phofo e tla le sethethefatsi ka paketeng e le 'ngoe.
Se ke oa leka ho hlapolla phofo ea Kokarnit ka mekhoa ea "e ntlafalitsoeng" - latela litaelo ka hloko, sebelisa solvent e hlahisitsoeng ke moetsi oa sethethefatsi.
Matšoao a ts'ebeliso ea Cocarnit ka ampoules ha a tšoane. Ts'ehetso ea metabolism e hlokahala bakeng sa maloetse a fapaneng le nakong ea lits'ebetso tsa ho hlaphoheloa 'meleng.
Haeba u hloka ho tsosa metabolism, ngaka ea hau e ka u fa Cocarnit. U ke ke ua "fana ka" eona.
Ts'ehetso ea moemeli
Matla a tšehetsang 'mele oa moriana ona o fanoa ke motsoako oa eona o nang le liminerale le livithamini tse ngata. E kenyeletsa lintho tse kang:
- trifosadenin (10 mg),
- cocarboxylase (50 mg),
- cyanocobalamin (0.5 mg),
- nicotinamide (20 mg),
- 5-deoxyadenosylcobalamin,
- li-excipients (metsi, lidocaine, glycine).
Ntho e 'ngoe le e' ngoe ka sebopeho e etsa mosebetsi oa eona. Trifosadenin le cyanocobalamin e hlohlelletsa metabolism, 'me cocarboxylase e thusa' mele ho kopanya li-acid, liprotheine, lipids, ho ntlafatsa tšebeliso ea tsoekere. 5-deoxyadenosylcobalamin e boetse e kenella ka mafolofolo phetohong ea metabolic. 'Me nicotinamide e na le phello e ntle ho li-tishu, e le e' ngoe ea melemo ea vithamine PP.
Motsoako oa Kokarnit o sebelisoa joang
Har'a bakuli ba nang le radiculitis le bohloko ba mesifa, Cocarnit e atile haholo. Haeba lefu la bohloko le boleloa haholo, moriana o le mong oa moriana o fuoa mokuli ka letsatsi (litekanyetso li ka eketsoa ka tlhahiso ea ngaka). Tekanyo e tloaelehileng ha e fetise matsatsi a 9. Theola phofo feela ka tharollo e tlang le eona. Ente e bohloko, leha e kopantsoe le lidocaine, empa bohloko ba mesifa bo bakoa ke ho khutlisetsoa metabolism.
Tlhahlobo e tloaelehileng ea kalafo ea Kokarnit e kenyelletsa ho tsoa ho 3 ho isa ho 9 ente ho kokobetsa boemo ba mokuli.
Haeba lefu la bohloko ha le phatlalatsoe, empa le iponahatsa, sethethefatsi se laetsoe ka palo ea liente tse 2-3 tsa ampoule e le 'ngoe ka beke bakeng sa libeke tse 2-3.
Ts'ebetso ea kalafo e hlahlojoa ke ngaka. Ho bohlokoa ho fana ka liente feela ho batho ba tsebang ho etsa sena. Haeba uena kapa baratuoa ba hau le sena litsebo tse ikhethileng, ikopanye le mooki sepetlele moo u fumanang kalafo, o tla thusa ho fana ka ente.
Lithethefatsi tse tšoanang
Liphetoho tsa lithethefatsi, tse nang le tšusumetso e tšoanang ea kalafo, li ka sebelisoa haeba ho sa khonehe ho reka Cocarnit (kapa ho na le li-contraindication le ho se mamellehe ka bomong). O ka sheba le ngaka ea hau hore na ke pheko efe e loketseng bakeng sa hau.
Sehlooho | Tlhaloso | Theko |
Actovegin | e etselitsoe ho hlaphoheloa ha metabolic ho mafu a bokong a bakang mathata | Li-ruble tse 600- 1400 |
Amitriptyline | pilisi, e karolo ea sehlopha sa litlhare tse thibelang likokoana-hloko | Li-ruble tse 30-60 |
Berlition 300 | e bontšitsoeng bakeng la lefu la tsoekere la polyneuropathy, e fokotsa tsoekere, e ameha lits'ebetsong tsa metabolic | Li-ruble tse 600- 900 |
Gabagamm | e bontšoa ha bohloko ho lefu la tsoekere la polyneuropathy | 380-1100 li-ruble |
Carbamazepine | antiepileptic, e thusa ho kokobetsa bohloko ba neurogenic ha ho hlokahala | Li-ruble tse 70 |
Kombilipen | ts'ebeliso ea lithethefatsi e ka etsahala ka neuritis, polyneuropathy, neuralgia | Li-ruble tse 150-250 |
Har'a lithethefatsi tse tšoanang, u ka fumana lithethefatsi tse theko e tlaase ho feta Kokarnit, eo li-ampoule tsa hae li jang li-ruble tse 600. Empa ho na le meriana le theko e boima haholo, empa ka nako e ts'oanang e sebetsa hantle kapa e loketseng boemo ba hau. Ho buisana le ngaka pele u reka lithethefatsi tse joalo hoa hlokahala.
Liente tsa Kokarnit
Motsoakoana o ntlafatsang lithethefatsi Cocarnit (Cocarnit) o boetse o ntlafatsa methapo ea kutlo ea methapo ea kutlo. Moriana o etsoa ke k'hamphani ea Baegepeta E.I.P.I.Co, ke ea sehlopha sa li-metabolic tse thehiloeng ho motsoako oa likarolo tse sebetsang tsa nicotinamide, cyanocobalamin, cocarboxylase le adenosine triphosphate.
Ampoules e na le lintho tse latelang tse sebetsang le tse thusang:
Phofo e pinki, tharollo e entsoeng ka mokhoa o hlakileng, o pepeneneng
Ts'oarello ea trifosadenine disodium trihydrate, mg / ml
Ho ts'oaroa ha cocarboxylase, mg / ml
Ts'oants'o ea cyanocobalamin, mg / ml
Ts'oarello ea Nicotinamide, mg / ml
Likarolo tse thusang tsa popeho
Glycine, methyl le propyl hydroxybenzoate
Metsi, lidocaine hydrochloride
Li-ampoule tse 3 tsa phofo ea 187 mg ka li-ampoules tse 3 tsa sol sol 2 ml ka pakete
Nakong ea kemolo
Lingaka li ka fana ka ente ea Kokarnit nakong ea kemolo, ha feela melemo e lebelletsoeng ho mme e feta kotsi e ka bang teng ho lesea. Maemong a mang, tšebeliso ea lithethefatsi ha u nkile ngoana e thibetsoe. Nakong ea kanyeso, tšebeliso ea moriana ha e lumelloe, hobane lintho tse sebetsang tsa motsoako li kenella ka lebeseng la matsoele mme li ka lematsa lesea.
Bocheng
Tšebeliso ea lithethefatsi e patiloe ho bana le bacha ba ka tlase ho lilemo tse 18. Sena se bakoa ke taba ea hore lithuto ha li so etsoa ka katleho le polokeho ea tšebeliso ea moriana sehlopheng sena sa batho ba lilemo tsena. Tšebeliso ea liente ntle le tumello ea ngaka e ka baka karabelo e sa laoleheng ho tsoa tsamaisong ea methapo ea methapo le ea pherekano.
Li-analog tsa Cocarnith
Ha ho na li-analogues tsa moriana ho latela karolo ea motsoako. Meeli e haufi haholo bakeng sa meriana ena ke:
- Thiamine chloride - e leng mofuta oa ente ea vithamine B1, e kenelletseng ho metabolism ea cocarboxylase, e pheta khaello ea ntho eo,
- Cocarboxylase - ente bakeng sa ts'ebetso ea coenzyme le thepa ea ho tloaela metabolism ea carbohydrate,
- Cardonate - li-capsules tse thehiloeng ho cocarboxylase,
- Vitaxone e nka sebaka sa sethethefatsi sa kalafo. E sebelisoa ho phekola neuralgia.
Theko Kokarnita
O ka reka Kokarnit ho la Moscow ka li-pharmacies kapa libaka tsa inthanete. Litsenyehelo tsa sethethefatsi li ipapisitse le mofuta oa k'hemiste le boemo ba 'maraka oa khoebo. Litheko tse lekantsoeng tsa lithethefatsi le litekanyetso tsa eona e tla ba:
Litsenyehelo tsa meriana, li-ruble
Cocarnit, li-ampoules tse nang le solvent 3 + 3 ml
Thiamine hydrochloride 1 ml 10 ampoules
Cocarboxylase, 50 mg 5 ampoules
Margarita, ea lilemo li 39 Mme wa ka o na le radiculitis. Ho se ho bonolo ho kokobetsa bohloko ka ho sebelisa litafole tse tloaelehileng, ka hona re sebelisa moriana oa Kokarnit. O ne a laetsoe ke lingaka. Kamora ho kenella ka har'a mesifa ea gluteal, mme o re lefu la bohloko le kokobela, ho ba bonolo hore a tsamaee. Habohlokoa ka ho fetisisa, ho hlophisoa ha vithamine ha ho bake litla-morao, ho mamelloa hantle.
Ruslan, ea lilemo li 66. Sethethefatsi Kokarnit se ile sa ngolloa ho 'na ka mor'a ho fumanoa ke neuralgia. Mokokotlo oa ka o ne o pentiloe hore ke se ke ka tsamaea, ho sisinyeha leha e le hofe ho ile ha nkutloisa bohloko haholo. Lingaka li ile tsa tla ntlong ea ka, tsa fana ka liente. Kamora liente tse peli, ho ile ha e-ba bonolo haholo ho nna, mme kamora thupelo ea beke ke ne ke ikemiselitse ho matha - ha kea ka ka utloa bohloko.
Vadim, ea lilemo li 57. Myocarditis e fumanoe selemong se fetileng. Ho ne ho le thata ho etsa mosebetsi o tloaelehileng - pelo ea ka e ile ea utloa bohloko, ho ekelletsa moo, ho hema, mathata a ho hema a ile a qala. Kamora hore lefu lena le mpefale le ho feta, ke ile ka ea sepetlele. Ha ke le moo ke ile ka fuoa mofuta oa ente ea Kokarnit. Ha ke kenya tharollo mokokotlong, e ile ea utloa bohloko, empa ke e mamella bakeng sa sephetho. Ha ke ntse ke le kalafong.
Cyanocobalamin
Maling, cyanocobalamin e tlama ho transcobalamin I le II, e e tsamaisang liseleng. E beoa haholo-holo ka har'a sebete. Puisano le liprotheine tsa plasma - 90%. Ka potlako le ka botlalo ka mor'a ts'ebetso ea intramuscular and subcutaneous. Phahamiso e kholo ka mor'a ho kenella ka har'a intramuscular e fumanoa kamora hora ea 1.
E ntšoa ka har'a sebete ho tsoa ka mpeng ebe e kenella maling. Ho felisoa ha halofo ea bophelo ke matsatsi a 500. E pepesetsoa ts'ebetso e tloaelehileng ea liphio - 7-10% ke liphio, e ka bang 50% - ke mala. Ka ts'ebetso e fokotsitsoeng ea liphio - 0-7% ke liphio, 70-100% - ke mala. E kenella ka har'a sehokelo sa placental ka lebese la matsoele.
Nicotinamide
E ajoa ka potlako masela ohle. E kenella ka har'a sethopo sa placental le ka lebese la matsoele. E tšeloa ka har'a sebete ho boptjoa ha nicotinamide-N-methylnicotinamide. E hloekisoa ke liphio.
Halofo ea bophelo ba plasma e ka ba lihora tse 1,3, boholo ba phepelo ea stationary e ka ba lilithara tse 60, 'me botlalo bohle bo haufi le 0,6 l / min.
Tekanyetso le tsamaiso
Moriana o kenngoa ka mokhoa o tebileng intramuscularly (ka har'a mesifa ea gluteus).
Maemong a bohloko bo boholo, kalafo e khothalletsoa ho qala ka ente ea intramia ea 1 ml (2 ml) ka letsatsi ho fihlela matšoao a bohloko a fola. Nako ea ts'ebeliso ke matsatsi a 9.
Kamora ho ntlafala ha matšoao kapa maemong a matšoao a itekanetseng a polyneuropathy: 1 ampoule makhetlo a 2-3 ka beke bakeng sa libeke tse 2-3. Mokhoa oa kalafo o khothalelitsoeng ke liente tsa 3-9, ho latela botebo ba lefu lena.
Nako ea kalafo le lithuto tse phetoang hangata li khethoa ke ngaka ho latela sebopeho sa lefu lena le boima ba lona.
Matšoao a overdose
Trifosadenin: ho feta tekanyetso e phahameng ea letsatsi le letsatsi (hoo e ka bang 600 mg bakeng sa motho e moholo) ho ka lebisa ho nts'etsopele ea matšoao a latelang: ho tsekela, ho fokotseha ha khatello ea mali, ho lahleheloa ke kelello ka nako e khutsitseng, arrhythmia, atrioventricular block II le III degree, asystole, bronchospasm, ventricular diphosiphoso, sinus bradycardia le tachycardia.
Cocarboxylase: Matšoao a latelang a tlaleheloa kamora ho fana ka lethal e fetang makhetlo a 100 lethalamo le khothalletsoang: mesifa ea mesifa, bofokoli ba mesifa, ho holofala, arrhythmia.
Cyanocobalamin: ka mor'a taolo ea botsoali ea lethal dose e phahameng, mathata a letlalo le eczematous le mofuta o mosesane oa makhopho a ile a bonoa. Ha e sebelisoa ka tekanyetso e phahameng, ho ka khoneha ho ntshetsa pele hypercoagulation, e senyehileng purine metabolism.
Nicotinamide: ha u sebelisa tekanyetso e kholo, hyperpigmentation, jaundice, amblyopia, bofokoli, ho mpefala ha leseling la peptic la mpeng le duodenum li ile tsa bonoa. Ka tšebeliso ea nako e telele, nts'etsopele ea steatohepatosis, keketseho ea khatello ea uric acid maling, mamello ea glucose e sa sebetseng e ile ea hlokomeleha.
Ho hlahisoa ha moriana ho emisoa hang-hang, ho fanoa ka phekolo ea matšoao, ho kenyelletsa le ho nyehlisa.
Ho sebelisana le lithethefatsi tse ling
Ho bakuli ba sebelisang li-hypoglycemic agents tsa sehlopha sa Biguanide (metformin), ka lebaka la ho ts'oaroa ha cyanocobalamin e tsoang pampiring ea gastrointestinal, ho ka fokotseha ho ata ha cyanocobalamin maling. Le baemeli ba bang ba hypoglycemic, litšebelisano tsa lithethefatsi ha li hlalosoe.
Cyanocobalamin ha e lumellane le ascorbic acid, letsoai la tšepe tse boima, thiamine, thiamine bromide, pyridoxine, riboflavin, folic acid.
U ke ke ua sebelisa ka nako e tšoanang cyanocobalamin ka lithethefatsi tse eketsang ho eketseha ha mali.
Ntle le moo, tšebeliso e tšoanang ea cyanocobalamin e nang le chloramphenicol e lokela ho qojoa.
Aminoglycosides, salicylates, lithethefatsi tsa antiepileptic, colchicine, litokisetso tsa potasiamo li fokotsa ho monya cyanocobalamin.
Ka ts'ebeliso e kopaneng ea lithethefatsi tse nang le trifosadenine e nang le dipyridamole, phello ea dipyridamole e matlafatsoa, haholo-holo phello ea vasodilating.
Dipyridamole e ntlafatsa phello ea trifosadenin.
Bofetoheli bo bong bo bontšoa ka tšebeliso ea moriana o kopaneng le purine derivatives (caffeine, theophylline).
O ka se kene ka nako e ts'oanang le pelo glycosides ka tekanyetso e kholo, kaha kotsi ea ho ba le liphetoho tse mpe tse tsoang tsamaisong ea pelo le methapo e eketseha.
Ka tšebeliso e le 'ngoe le xanthinol nicotinate, phello ea lithethefatsi e fokotsehile.
Nicotinamide e bonts'a litlamorao tsa matla a ho fetoha, litlamorao, hammoho le lithethefatsi tse felisang kalafo.