Glycyrrhizic acid

Foromo C42H62O16, lebitso la lik'hemik'hale: 20-beta-Carboxy-11-oxo-30-norolean-12-en-3-beta-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid.
Sehlopha sa litloholo: antimicrobial, antiparasitic and anthelmintic agents / antiviral agents / Antiviral agents (ntle le HIV).
Ketso ea pharmacological: antiviral.

Melemo ea pharmacological

Glycyrrhizic acid e sebetsa khahlanong le vaerase ea RNA le DNA, ho kenyeletsoa likarolo tse fapaneng tsa Varicella zoster, li-virus tsa Herpes simplex, cytomegaloviruses, vaerase ea papilloma ea motho. Mohlomong litlamorao e ka 'na ea amahanngoa le ho kenella ka har'a motsoako oa li-interferon. Liseleng tse nang le tšoaetso, glycyrrhizic acid e emisa phosphorylation ea liprotheine tsa lisele tse koetsoeng ke vaerase ka ho thibela phosphokinase. Mehatong ea pele, phetisetso ea vaerase e ea kena-kenana, e leng ho etsang hore virion e tsoe capid. Glycyrrhizic acid e kenya livaerase ka ntle ho lisele, ha li-virus tsa herpes simplex le herpes zoster li sa fetohe. E tlola bokhoni ba vaerase ba ho theha likarolo tse ncha tsa sebopeho mme e thibele ho kenella ha likarolo tse sebetsang tsa vaerase ka seleng. Glycyrrhizic acid e thibela livaerase ka har'a lintho tse se nang chefo ho lisele tse sa sebetseng. Ho amoheloa hoa systemic ho lieha. Ha e sebelisoa sebakeng sa heno, glycyrrhizic acid e na le tropism e phahameng bakeng sa lisele tse nang le tšoaetso ea vaerase 'me e ipokella ho lesion foci. Mefuta ea vaerase e hananang le iodouridine le acyclovir e ameha haholo ho glycyrrhizic acid. Glycyrrhizic acid e boetse e na le anti-inflammatory, analgesic athari, e ntlafatsa ho nchafatsoa ha lisele ponts'ong ea pejana ea lefu la vaerase, le ka mefuta ea liso.

Kalafo ea tšoaetso ea lefu la botšehali e hlahisoang ke vaerase ea mofuta oa 2 oa Herpes (mantlha ea mantlha, e phetoang nako le nako), kalafo ea tšoaetso ea mucous membrous le letlalo e bakoang ke papillomavirus ea motho, kalafo ea tšoaetso ea letlalo e bakoang ke vaerase ea Varicella zoster (e le karolo ea kalafo e felletseng). colpitis, vaginitis, thibelo ea tšoaetso e tloaelehileng ea vaerase e fetisoang ka thobalano.

Mokhoa oa ts'ebeliso ea glycyrrhizic acid le lethal dose

C cream: sebelisa makhetlo a 3-5 ka letsatsi sebakeng se amehileng. Setei: ka thipa - ka makhetlo a 3-4 ka letsatsi ka matsatsi a 7-10 (sebelisa hape ho ka etsahala kamora matsatsi a 10), kantle - ho tloha hole le 4-5 cm, fafatsa makhetlo a 6 ka letsatsi sebakeng se amehang metsotsoana e 5 (mohlomong ho fihlela matsatsi a 10).
Phekolo e emisoa ha matšoao a ho teneha a hlaha. Haeba ho hlaha lephoka le sa thabiseng, etela ngaka. Phekolo ea tšoaetso ea letlalo e bakoang ke vaerase ea Varicella zoster, tšebeliso ea kantle ea glycyrrhizic acid e lokela ho kopantsoe le tsamaiso ea molomo ea li-ejenti tse thibelang mafu.

Mabitso a khoebo bakeng sa motsoako o sebetsang oa glycyrrhizic acid

Lithethefatsi tse kopaneng:
Glycyrrhizic acid + Phospholipids: Phosphogliv®, Phosphogliv® forte,
Ambroxol + Sodium glycyrrhizinate + Khomo ea litlama ea thyme e ntšoa: Codelac® Broncho e nang le thyme,
Ambroxol + Sodium glycyrrhizinate + Sodium bicarbonate + Thermopsis e omeletseng: Codelac® Broncho.

Lisebelisoa tsa lik'hemik'hale

Glycyrrhizic acid e fumanoa ka bongata bo boholo motso oa licorice. E sebelisoa e le letsoai indastering ea lijo le litabeng tsa meriana (li-anti-inflammatory, expectorant, antiulcer, lowers testosteroneho banna, ho fokotsa khatello ea mali) Acid hangata e eketsoa ka litlamong tsa mafura.

Pharmacodynamics le pharmacokinetics

Ntho e na le matla a ho thibela ts'ebetso ea tlhahiso. phosphokinasesemisa mekhoa phosphorylationliprotheine tse liseleng tse nang le vaerase. Sesebelisoa se kenella ka botlalo le ka mokhoa o sa fetoheng herpes zoster vaerase le herpesha li le ka ntle ho lisele. Ho na le tšibollo ea kenyelletso ea likaroloana tsa vaerase tse sebetsang liseleng tse phetseng hantle, moemeli ea lonya o lahleheloa ke bokhoni ba ho kopanya likarolo tse ncha tsa sebopeho.

Ha motsoako o sebelisoa ka mokhoa o hlophisitsoeng, o na le matla a ho bokellana liseleng tse amehang, athe ha li oele ka mokhoa o hlophisitsoeng.

Matšoao a ho sebelisoa

Moriana o laetsoe ts'ebeliso ea kantle:

• bakeng sa tšoaetso ea letlalo, liphatsa tsa lefutso, mucosa le molomo vaerase ea herpes (Mofuta oa 2)
• bakeng sa kalafotinea versicolore le karolo ea kalafo e rarahaneng,
• joalo ka prophylactic khahlano le vaerase e tšoaetsanoang ka thobalano.

Litlamorao

Ka lebaka la ho amoheloa ka mokhoa o tlase haholo oa litokisetso tsa acid ea glycyrrhizic acid, ho ba le maemo a mabe ka seoelo.

E ka bonahatsa allergy ka moriana, o bonahatsoang ke ho hlohlona le ho se ts'oarehe sebakeng sa kopo, nts'etsopele ea mefuta e meng ea mafu a letlalo ha e qheleloe ka thoko.

Glycyrrhizic acid, litaelo tsa tšebeliso (mokhoa le litekanyetso)

Mokhoa oa litekanyetso li beoa ka bonngoe.

Spray e sebelisoa bakeng sa ts'ebeliso ea kantle. Moriana o fafatsoa ka nako e itseng (metsotsoana e 'maloa) holim'a metsi a amehang a le bolelele ba cm 5. Ho sebelisoa hangata - makhetlo a ka bang 6 ka letsatsi.

Nako ea kalafo e tsoa matsatsing a 5 ho isa ho a 10.

Ka mokhoa o tšabehang, lithethefatsi li laetsoe makhetlo a 3-4 ka letsatsi, bakeng sa beke e le 'ngoe - matsatsi a 10. Kamora matsatsi a 10, ho khothalletsoa ho pheta thupelo hape.

Letsoai le sebelisoa sebakeng se amehileng makhetlo a 3-5 ka letsatsi bakeng sa beke kapa matsatsi a 10.

Litokisetso tse nang le (Analogs)

Khoebo Khoebo Glycyrrhizic Acid: Trisodium letsoai la glycyrrhizic acid, Epigen Intim, Glycyrrhizin.

Motsoako oa glycyrrhizic acid + Phospholipids e litokelong: Hepabos, Phosphogliv, Phosphogliv Forte.

Tšebeliso ea meriana

Moemeli oa ts'oaetso bakeng sa ts'ebeliso ea kantle le ea lehae. Glycyrrhizic acid e sebetsa khahlano le livaerase tse nang le RNA, ho kenyeletsa mefuta e fapaneng ea Herpes simplex, vaerase tsa Varicella zoster, livaerase tsa papilloma ea motho, cytomegaloviruses. Matla a antiviral ho bonahala a amana le ho kenella ha sebopeho sa interferon. Ho kenella ho pheta-pheta ha vaerase methating ea pele, ho etse hore virion e tsoe ka har'a capid, ka tsela eo e thibela ho kenella ha eona ka har'a lisele. Sena se bakoa ke thibelo e itšetlehileng ka tekanyetso ea phosphorylating kinase P. E sebetsana le likarolo tsa kokoana-hloko, e fetola maemo a fapaneng a potoloho ea vaerase, e tsamaeang le ts'ebetso e sa fetoheng ea likaroloana tsa vaerase (tse maemong a lokolohileng kantle ho lisele), li thibela ho kenngoa ha likaroloana tsa vaerase tse sebetsang kahare ea sele, hammoho le bokhoni bo senyehileng. vaerase ho motsoako oa likarolo tse ncha tsa sebopeho.

E thibela livaerase tse ka har'a lintho tse seng chefo ho lisele tse sebetsang hantle.

Likokoana-hloko tsa vaerase tse loantšang acyclovir le iodouridine li ameha haholo ho glycyrrhizic acid.

E boetse e na le litlamorao tse matlafatsang khahlanong le ho ruruha, analgesic le tishu ka bobeli lipontšong tsa pele tsa ts'oaetso ea vaerase le ka mefuta ea liso.

E matlafatsa ts'ebetso ea lithethefatsi tsa glucocorticosteroid ha li etsoa hammoho. Thepa ena e sebelisoa ka mafolofolo ho fokotsa nako ea kalafo ka lithethefatsi tsa lihormone bakeng la asthma ea bronchial, ka kalafo ea kantle le sehlopha sa corticosteroids sa class.

Lisebelisoa tsa lithethefatsi |Lintho tse ntle tsa acid

The glycyrrhizin e teng motso oa licorice, e monate ka makhetlo a leshome ho feta tsoekere e tšoeu e tloaelehileng, ts'ebetsong ea eona e ts'oana hantle le ketso ea lihormone tsa adrenal cortex ke cortisol. Ka lebaka lena, asiti e na le antimicrobial, anti-allergenic le anti-inflammatory.

Glycyrrhizic acid e thusa ho loants'a mafu a qoqotho, le li-pathologies tse amanang le lefu la tsoekere, mohlala, khatello ea mali le mafu a ho potoloha.

Acid e na le phello e molemo melerong ea mucous; ho lefu la tsoekere, e tsosa tlhahiso ea insulin. Ntho ena e ke ke ea khona ho nka tsoekere ka botlalo, hobane ho na le litšebelisano tsa tšebeliso ea nako e telele le tse ngata.

Ntho ena e nkuoa e le moriana o motlehali ho bakuli ba nang le lefu la tsoekere ba hlalosoa e le mokhoa oa ho:

1. ho ntlafatsa ts'ebetso ea kelello,
2. moea oa eketseha
3. ho kokobetsa mokhathala.

Ntle le moo, ho khothalletsoa ho e sebelisa e le karolo ea lino tse tahiloeng tsa tonic, e le karolo ea linoko. Hangata acid e eketsoa ka lihlahisoa tsa indasteri.

Phapang ke eng ea ntho ena

Meriana e thehiloeng ho glycyrrhizic acid e bontšoa bakeng la lefu la tsoekere moo ho nang le mafu: herpes zoster, human papillomavirus, ts'oaetso ea mantlha le ea pheta-pheto, nonspecific colpitis, vaginosis. Hape, lithethefatsi li na le bokhoni ba ho thibela ts'oaetso ea herpes hape.

Tšebeliso ea acid e sa lumelloang le e sa laoleheng e thibetsoe, haholo nakong ea kemaro ea nako efe kapa efe, maikutlo a feteletseng a ntho e sebetsang, nakong ea ho anyesa.

Litekanyetso tsa lithethefatsi kamehla li itšetleha ka lipontšo, mofuta oa litekanyetso tsa glycyrrhizic acid. Ha mokuli oa lefu la tsoekere a batla ho tlosa liso tsa letlalo la herpetic, ho khothalletsoa ho lokisa tranelate, e kenngoe ka sekhahla sebakeng se amehang, 'me libaka tse phetseng hantle li lokela ho haptjoa:

• khafetsa ea tšebeliso - ho fihlela makhetlo a 6 ka letsatsi,
• kalafo e etsoa ho fihlela fola e felletseng,
• tšebeliso e kopaneng ea khonahala.

Le papillomavirus ea motho, batho ba nang le lefu la tsoekere ba fuoe glycyrrhizic acid hammoho le lithethefatsi tse ling, ho ekelletsa moo, ba sebelisa chelete bakeng sa tšenyo ea mmele kapa ea lik'hemik'hale. Mokokotlo oa tšebeliso ke makhetlo a 6 ka letsatsi.

Ka mofuta oa lefu la tsoekere la 1 lefu la tsoekere le nonspecific colpitis, kalafo e qala ho tloha matsatsing a 7 ho isa ho a 10, moriana o fanoa ka har'a intravaginally. Bakeng sa banna, ho khothalletsoa ho kenngoa hoa mafura ka kotloloho ho urethra.

Motsoako oa glycyrrhizic acid o fumaneha litokisetsong tsa Epigen haufi, Glycirat. Litaelo tsa tšebeliso ea glycyrrhizic acid li re khahlano le semelo sa kalafo, batho ba nang le lefu la tsoekere ba lokela ho fana ka livithamini le liminerale.

Boithuto bo thusitse ho tseba sebopeho le sebopeho sa glycyrrhizic acid, ho fumanoe hore limolek'hule tsa ntho ena li tšoana le limolek'hule tsa lihormone tse hlahisoang ke adrenal cortex.

Ho sibolla hona ho lumelletse tšebeliso ea asiti bakeng sa kalafo ea lihormone.

Mabaka a ho fetoha ho feta tekano, liphetoho tse mpe, tšebelisano

Ho fihla joale, ha ho na tlhahisoleseling ka mathata a mmele ka tšebeliso e feteletseng ea lithethefatsi. Leha ho le joalo, litšitiso tse ka 'nang tsa hlaha tsa' mele lia tsejoa, ka mohlala, e ka ba makhopho, ho ruruha, ho hlohlona le ho choachoasela. Matšoao a joalo a khethollehile ho feta maemong a khafetsa.

Lithethefatsi tse nang le glycyrrhizic acid ho phekolo e kopaneng ha li sebelisane le lithibela-mafu, li-antiseptics, li-painkiller le lithethefatsi tse khahlanong le ho ts'oaroa, li ke ke tsa li sebelisa.

Ts'ebeliso e ts'oanang le mahlahana a mang a antiviral e na le tšusumetso ea ts'oaetso ea antiviral.

Re bua ka litafole le lithethefatsi, litšoantšiso tsa bona:

Bakeng sa tlhaiso-leseling e batsi ka ho arolelana, ka kopo bala tataiso ea tšebeliso ea lithethefatsi.

Bakeng sa nako ea kalafo, mokuli o lokela ho latela lijo tse nang le phepo e nepahetseng, ho ja livithamini le litokisetso tsa liminerale. Joalokaha litlhahlobo tsa bakuli li bonts'a, ts'ebeliso ea ntho ena ha e so ka e ama bophelo ba bona bo bobe, mathata ha a hlahe.

Ts'ebeliso e sa feleng ea glycyrrhizinate joalo ka sopho e baka leaching ea sodium le potasiamo ho tsoa 'meleng, e sa amoheleheng ebile e tletse litlamorao tse kotsi ho lefu la tsoekere.

Mohloli oa Acid

Glycyrrhizic acid e ka fumaneha ho licorice rhizomes. Semela se sebelisetsoa tlhahiso ea meriana le bakeng sa ho etsa tee ho felisa mathata a metabolic. Seno se joalo se thusa ho theola tsoekere e maling kapele, e hanyetsa mafu a vaerase, atherosulinosis ea methapo ea mali le khatello ea mali.

Ho etsa tee, ho hlokahala hore u nke khalase ea metsi a belang le ligrama tse leshome tsa sehlahisoa, beha likarolo ka har'a bate ea metsi, 'me u tšoare metsotso e 15. Ebe moetso o tla hloka ho ts'oaroa hora e 'ngoe, sehlahisoa se felisitsoeng se tlhotloa ka gauze, se tlisoa ka metsi a phehiloeng ho ea boholo ba eona ba pele. Nka senoelo ka likarolo tse nyane ho pholletsa le letsatsi, thupelo e khothalletsoang ke matsatsi a 14.

Ho boetse ho na le risepe ea ho etsa seno se seng se sebetsang, se ka bang le glycyrrhizic acid. Li-folds tsa linaoa, elecampane, makhasi a blueberry, motso oa burdock, licorice, motso oa dandelion li nkuoa, li khabeloa ka grinder ea kofi, tšela khaba ea pokello ka khalase ea metsi a belang ebe u tlohela metsotso e 25.

Haeba u phekola bophelo ba hau hantle, u noe joalo kamehla, kamora nako e itseng 'mele o tletse lintho tse nang le thuso,' me glycyrrhizic acid e tla lebisa maemong a tsoekere a mali, e matlafatse ts'ireletso le ho ntlafatsa boemo ba mokuli ea nang le lefu la tsoekere.

Tlhahisoleseling ka li-sweeteners e fanoa ka video videong ena.

Glycyrrhizic acid theko, moo u ka rekang

Reka li-gel Epigen thobalano ho khoneha li-ruble tse 723, botlolo e nang le matla a 250 ml.

Litsenyehelo tsa lithethefatsi Phosphogliv ke li-ruble tse ka bang 500 bakeng sa likhaba tse 50.

Thuto: O qetile Kolecheng ea Rivne State Basic Medical College ka lengolo la degree. O fumane lengolo la univesithi ea Vinnitsa State Medical. M.I. Pirogov le internship e thehiloeng ho eona.

Phihlelo: Ho tloha ka 2003 ho fihlela ka 2013, o ile a sebetsa e le morekisi oa meriana le mookameli oa k'hemiste ea meriana. O ile a fuoa mangolo le likhetho bakeng sa lilemo tse ngata tsa mosebetsi o hlokometsoeng ka hloko. Lingoloa tse mabapi le lihlooho tsa bongaka li ile tsa phatlalatsoa likhatisong tsa lehae (likoranteng) le liphatlalatsong tse fapaneng tsa inthanete.

Likopo tse ling

Motsoako o boetse o fanoa e le o khothalletsang, haholo-holo ho ikoetlisa ka matla. Healing glycyrrhizic acid, ts'ebeliso ea eona e hlahisoang molemong oa litlolo bakeng sa kalafo ea letlalo le bothata ba letlalo, e sebelisoa ho litlolo, li-lotion le tonics bakeng sa letlalo le nang le bothata.

Ntho ena e khothaletsa ts'ebetso ea metabolism ea metsi a letsoai, e hloekisa, e hloekisa, e nolofatsa le ho fokotsa ho teneha.

Ke meriana efe e sa lokelang ho nooa?

- ka li-corticosteroids (litlhare "Licorice extract") ha li na monyetla. E ka fana ka litholoana tse ntle le tse mpe. Ho molemo hore u se ke oa kopanya lithethefatsi ka nako e le 'ngoe.

- ka diuretics - e tla lebisa tahlehelong e kholo ea potasiamo.

- ka lithibela-pelehi tsa molomo - li tla baka karabelo.

Pele ho kalafo, o lokela ho bona ngaka e tšoanelehang e tla u ngolla mofuta o sireletsehileng le o sebetsang oa kalafo.

U ka e sebelisa joang?

Aerosol e fafatsoa libakeng tse amehang makhetlo a tšeletseng ka letsatsi. Nako ea kalafo e ka fihlela matsatsi a leshome. Kirimi e tlotsitsoe makhetlo a 'maloa ka letsatsi.Haholo-holo bakeng sa tšebeliso ea botšehali, ho na le nozzle e bonolo, e leng tube e telele e nang le nebulizer.

Pele o sebelisoa ka mong le e mong, hlatsoa nko ka sesepa. Kamora ho sebelisoa, ho hlokahala ho robala metsotso e 'maloa e le hore moriana o ananeloe. Banna ba ka kenya sethethefatsi kahare ho urethra ka bolelele ba 1 cm.

Ka ts'oaetso ea papillomavirus le herpetic, moriana o hloekisoa ho litho tsa botona, moo sebopeho sa genital le herpetic se fumanehang. Haeba matsatsing a mahlano papillomas e sa nyamela ka botlalo, e tlosoa e sebelisa tšenyo ea lik'hemik'hale kapa ea 'mele, ebe kalafo e nang le sehlahisoa e phetoa hape.

Ho latela maikutlo a basebelisi, phello ea kalafo e bonoa ka letsatsi la boraro kamora kalafo. Mekhoa e ntse e nyamela ka botlalo, bophelo bo botle ka kakaretso boa ntlafala, ha ho na thabo. Lingaka li boetse li nka kalafo ena e le e 'ngoe e molemohali merianeng ea meriana.