Matšoao a Tafole a Thrombo ACC

Mofuta oa litekanyetso tsa ho lokolloa ha Thrombopol ke matlapa a koahetsoeng ka har'a ente: pinki, biconvex, pota (ka marang-rang a li-pcs tse 10. Ka karete e pakiloeng ea lilakane tse 3, 5 kapa 6, ka marang-rang a lilakane tse peli.

Letlapa la 1

• ntho e sebetsang: acetylsalicylic acid - 75 kapa 150 mg,
• likarolo tse thusang: starch ea poone, starch ea sodium carboxymethyl, cellulose ea microcrystalline,
• khetla: hypromellose, Acrylic Ke motsoako bakeng sa matlapa a koahelang, sebopeho ke sodium lauryl sulfate, sodium hydrogen carbonate, methacotic acid Copolymer (mofuta C), talc, triethyl citrate, titanium dioxide, colloidal silicon dioxide, dae e krimsson (Ponceau 4R).

Pharadodynamics

Thrombopol ke e 'ngoe ea li-NSAIDs (lithethefatsi tse seng tsa antiidalidal), li-antiplatelet agents.

Motheo oa ts'ebetso ea ts'ebetso ea acetylsalicylic acid ke thibelo e ke keng ea fetoloa ea COX-1 (cycloo oxygenase), e lebisang ho thibaneng ho kenyelletsoeng ha thromboxane A₂ le khatello ea litlatsetso tsa polasetiki.

Matla a antiplatelet a hlaha le kamora ts'ebeliso ea litekanyetso tse nyane tsa moriana, bolelele ba phello ea lona kamora hore tekanyetso e le 'ngoe ke matsatsi a 7. Acetylsalicylic acid e ka sebelisoa ho phekola le ho thibela maloetse / maemo a latelang: infarction ea myocardial, mathata a methapo ea varicose, lefu la pelo.

Ntle le moo, ntho ena e na le phello ea li-analgesic, anti-inflammatory le antipyretic.

Ka lebaka la ho koaheloa ha litafole ka har'a ente, acetylsalicylic acid e ntšoa tikolohong e nang le alkaline e ngata ea duodenum, e thusang ho fokotsa phello e halefisang ea mucosa ea gastric.

Mofumahali

Ho amoheloa ha acetylsalicylic acid e tsoang Thrombopol ho qala lihora tse 3-4 kamora ho nka moriana (sena se tiisa thibelo e sebetsang ea ho felisoa ha matlapa ka mpeng). C_max (boholo ba mahloriso a ntho) ho lipalo-palo tsa plasma 6.72 le 12,7 μg / ml (bakeng sa matlapa a 75 le 150 mg, ka ho latellana), nako ea ho e fihlela ke lihora tse ka bang 2-3. Ho kenngoa ha moriana ho liehisa ho ba teng ha lijo ka mpeng ea mpa.

AUC (sebaka se tlasa khatello ea nako ea mahloriso) ke 56.42 le 108.08 μg × h / ml (bakeng sa matlapa a 75 le 150 mg, ka ho latellana).

Acetylsalicylic acid haholo mme e kenella ka potlako maro a 'mele le linama tse ngata. Tekanyo ea tlamo ea eona ea liprotheine tsa plasma e khethoa ke mahloriso.

Ho ajoa ka bongata ho lekana le 0,15-0.2 l / kg; e ntse e eketseha ka nako e ts'oanang le keketseho ea khatello ea serum ea "thrombopol" maling.

Ho fapana le salicylates tse ling, khahlanong le semelo sa taolo e pheta-phetoang ea lithethefatsi, acid e senang hydrolyzed acetylsalicylic acid ha e bokelle serumeng ea mali.

Ka tsela e itseng acetylsalicylic acid e tšeloa metsoako nakong ea ho monya. Ts'ebetso ena e etsahala tlasa ts'usumetso ea li-enzymes haholo-holo ka har'a sebete. Ho thehiloe metabolites e latelang (e fumanoang ka har'a moroto le liseleng tse ngata): phenyl salicylate, glucuronide salicylate, le salicyluric acid.

T_1/2 (halofo ea bophelo) ea asiti ea acetylsalicylic e tsoang plasma ea mali e pakeng tsa metsotso e 15 ho isa ho e 20.

Ke 1% feela ea lethal e tsoang ka hanong e hlahisoang ka mokhoa oa acid e se nang hydrolyzed acetylsalicylic acid, tse ling kaofela e le salicylates le metabolites ea tsona.

Ha ho na le ts'ebetso ea ho kula e sa sebetseng hantle, 80-100% ea tekanyetso e le 'ngoe e nkoe ke liphio nakong ea lihora tse 24-72.

Ts'ebetso ea metabolic ho basali e tsamaea butle (ka lebaka la ts'ebetso e tlase ea li-enzyme tse serum ea mali).

Bakeng sa bakuli ba nang le bothata ba ho phekoloa ka methapo, hammoho le basali ba baimana le masea a sa tsoa tsoaloa, salicylates e ka tlosa bilirubin kamanong le albin, e tlatsetsang ponong ea bilirubin encephalopathy.

Matšoao a ho sebelisoa

• Angina Khmer
• acute myocardial infarction (thibelo ea infraction ea myocardial ea mantlha moo ho nang le mabaka a kotsi, haholo-holo lefu la tsoekere, hyperlipidemia, khatello ea mali ea methapo, botenya, ho tsuba, botsofaling, le thibelo ea infraction ea myocardial).
• stroke: (thibelo, ho kenyelletsa le bakuli ba nang le mafu a nakoana a amanang le ho ruruha ha pelo),
• kotsi ea nakoana e amanang le lefu la mokokotlo (thibelo),
• thromboembolism (thibelo nakong ea ts'ebetso le ka mor'a ho kenella ka sekepeng ka likepeng, haholo-holo, coronary artery endarterectomy, carotid artery angioplasty, arteriovenous shunting),
• vein thrombosis e tebileng le thromboembolism ea methapo ea methapo ea methapo le makala a eona (thibelo, ho kenyelletsa le ho bakuli kamora ho buuoa ho hoholo nakong ea ho thibela mmele ka nako e telele).

Contraindication

• ho mpefala ha bohloko ba ho ruruha le ho ruruha ha liso ka mpeng.
• motsoako oa asthma ea bronchial, polyposis e sa khaotseng ea li-sinanas / nko le ho se mamelle acid e acetylsalicylic,
• hemorrhagic diathesis,
• lefu la ka mpeng,
• Tšebeliso e le 'ngoe le methotrexate ka tekanyo ea 15 mg ka beke kapa ho feta,
• Asthma ea bronchial e susumetsoang ke salicylates le NSAIDs,
• 'Na le III re hlokometse bokhachane, le nako ea ho anyesa,
• lilemo tse 18
• ho se mamelle setho ka seng sa karolo ea lithethefatsi, hammoho le li-NSAID tse ling.

Se amanang (Thrombopol e behiloe tlasa tsamaiso ea bongaka):

• polyposis ea nko,
• gout
• mafu a sa foleng a phefumoloho,
• hyperuricemia
• renal / Ho hloleha ha sebete,
• nalane ea liso tsa ka mpeng le lisele tsa ka mpeng kapa mali a tsoang ka mpeng,
• asthma ea lefu la bronchial,
• hay fever
• allergy
• ts'ebeliso e le 'ngoe le li-anticoagulants,
• Ho sebelisoa ka nako e le 'ngoe le methotrexate ka lethal dose ho fihlela ho 15 mg ka beke,
• II trimester ea bokhachane.

Litlamorao

• tsamaiso ea tšilo ea lijo: ho eketsa ts'ebetso ea li-enzyme tsa sebete, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho opeloa ke pelo, bohloko bo ka mpeng, liso tsa ka mpeng tsa mucous tsa mpa le duodenum, ho kenyelletsa le madi a tsoang ka mpeng,
• tsamaiso ea methapo e bohareng: tinnitus, kizunguzungu,
• tsamaiso ea matšoafo: bronchospasm,
• karohano e bakoang ke ho kula: Edema ea Quincke, urticaria,
• hematopoietic system: Ho ata ha mali, hangata - khaello ea mali.

Bongata

Matšoao a pele a overdose a bonahala ka mokhoa oa ho nyekeloa, ho hlatsa, tinnitus le ho hema ka potlako, ho ekelletsa moo, ho ka hlaha mathata a latelang: ho senyeha ha pono, ho se utloe litsebeng, ho ferekana hoa koloi, ho opeloa ke hlooho, ho otsela, khatello ea maikutlo. Ka tšebeliso e matla ea tahi, ho ka hlaha likhaohano khafetsa ka har'a motlakase oa motlakase le acid-base (dehydration and metabolic acidosis).

Matšoao a botahoa a bonolo / a lekanyelitsoeng a hlaha kamora ts'ebeliso ea acid e le 300-300 mg / kg acetylsalicylic acid. Tekanyetso e feteletseng ea kholo e hlaha ka lethal dose ea 300-500 mg / kg. Tekanyetso ea ho feta 500 mg / kg e ka bolaea.

Ha ho na le litlhare tse tobileng bakeng sa thrombopol. E le pheko, molemong oa ho fokotsa ho amoheloa ha moriana, ho bontšoa mehato e latelang: ho hlatsa le ho hlatsoa mpa. Mehato ena e sebetsa lihora tse 3-4 kamora ho sebelisa moriana, maemong a ho nka tekanyetso e kholo, nako ena e atolosoa ho lihora tse 10. Bakeng sa ho fokotsa ho amoheloa ha ntho, ho hlokahala hore ho nkuoe ho emisoa ha khase e kenngoeng (lethal dose ea batho ba baholo - 50-100 g, bana - 30-60 g), ha ho ntse ho lekantsoe mokelikeli oa motlakase oa metsi (haeba ho hlokahala, o tlameha ho phetoa ka nako e nepahetseng).

Molemong oa phekolo ea acidosis le ho potlakisa tlhahiso ea asiti ea acetylsalicylic ke liphio, tsamaiso e kenelletseng ea sodium bicarbonate e bontšitsoe, pH e lokela ho lula e le maemong a 7-7,5.

Maemong a ho tahoa haholo, hemodialysis kapa peritoneal dialysis e bontšoa.

Ka lebaka la monyetla oa ho phefumoloha acidosis, ho sebelisa lithethefatsi tse thibelang tsamaiso ea methapo e kholo (joalo ka barbiturates) ho thibetsoe. Ha ho na le mathata a phefumoloho, ho hlokahala ho netefatsa patency ea moea le phihlello ea oksijene. Haeba ho hlokahala, etsa intubracheal intubation 'me u fane ka moea o hlophisang moea.

Litaelo tse khethehileng

Acetylsalicylic acid e ka baka bronchospasm, hape ea lebisa ho litlhaselo tsa asthma le litlamorao tse ling tsa hypersensitivity. Lisosa tse ka sehloohong tsa kotsi ke nalane ea asthma ea bronchial, hay fever, polyposis ea ka mpeng, mafu a phefumoloho a sa foleng, ho hlekefetsoa ha lintho tse ling ho lithethefatsi tse ling (mohlala, karabelo ea letlalo, ho hlohlona, ​​hives).

Tšebeliso ea asiti ea acetylsalicylic e ka baka ho fapana ho tebileng ha mali nakong ea / ka mor'a ho kenella ts'ebetsong. Mabapi le sena, matsatsi a 5-7 pele ts'ebetso e reriloeng, kalafo e lokela ho khaotsa.

Monyetla oa ho tsoa mali o eketseha ka tšebeliso e kopaneng ea thrombopol le li-anticoagulants, li-inhibitors tsa platelet le lithethefatsi tsa thrombolytic.

Methapo e fokolang ea acetylsalicylic asiti maemong a ho lemala (ho fokotsoa ha uric acid excretion) ho ka baka gout.

Ka ho kopantsoe ha thrombopol le methotrexate, menyetla ea ho etsa lintho tse bohloko ho tsoa lithong tsa hematopoietic ea eketseha.

Litekanyetso tse phahameng tsa acetylsalicylic acid e hlahisa phello ea hypoglycemic, e lokelang ho tsotelloa bakeng sa bakuli ba nang le lefu la tsoekere ba fumanang lithethefatsi tse nang le phello ea hypoglycemic.

Ka ts'ebeliso e kopaneng ea li-glucocorticosteroids tse nang le thrombopol, ho fokotseha ha khatello ea eona maling ho bonoa, 'me ka mor'a ho felisoa ha glucocorticosteroids, ho ka etsahala ka mokhoa o feteletseng oa salicylates.

Tšebeliso e kopanetsoeng le ibuprofen ha e khothalletsoe, hobane e fokotsa ts'ebetso ea acetylsalicylic acid.

Ho kopana ha acetylsalicylic acid le ethanol ho eketsa monyetla oa ho senya mucous membrane ea seterata sa mpa le nako e telele ea ho tsoa mali.

Ho sebelisa lithethefatsi tse fetang tekano ho kotsi haholo ho bakuli ba tsofetseng. Ka lebaka la hore ho bakuli ba kaholimo ho lilemo tse 65, ho fokotseha ha ts'ebetso ea liphio ho ka etsahala, sehlopha sena sa bakuli se lokela ho fuoa thrombopol ho litekanyetso tse fokotsang.

Bokhachane le pelehi

• 'Na le III re hlohlelletsa ho ima: lithethefatsi li hanana le ts'ebeliso ea ts'ebetso ea Thrombopol ho "trimester" e lebisang ho arohaneng hoa liphoso tsa kaholimo le pelo, ho "trimester" ea III, ho thibela ts'ebetso ea pelehi, ho koaloa kapele ha ductus arteriosus ka popelong, ho eketseha ha mali ho' m'a / lesea le pelehi ho beleha ho ka baka hemorrhage ea intracranial, haholoholo masea a pele ho nako,
• II trimester ea bokhachane: Thrombopol e ka sebelisoa feela kamora tlhahlobo e felletseng ea tekanyo ea melemo / kotsi,
• Lebakeng: moriana o kopantsoe.

Ho sebelisana le lithethefatsi

Lithethefatsi, phello ea eona e ntlafatsoa ha e kopantsoe le thrombopol:

• methotrexate: e amahanngoa le ho fokotseha ha clearance clearance le ho falla ha eona ho tsoa lipuisanong le liprotheine, motsoako o kopantsoe kapa o hloka tlhokomeliso (ha o sebelisoa ka tekanyetso kapa ka holimo ho 15 mg ka beke, ka ho latellana),
• heparin le anticoagulants e sa tobang: e amanang le ts'ebetso ea liplatelese e sa sebetseng le ho fallisoa ha li-anticoagulants tse sa tobang puisanong le liprotheine,
• lithethefatsi tsa thrombolytic le li-inhibitors tsa liplatelete (ticlopidine),
• digoxin: e amanang le ho fokotseha ha makhopo a eona a sesapo,
• hypoglycemic agents (insulin le sulfonylurea derivatives): e amahanngoa le thepa ea hypoglycemic ea acetylsalicylic acid ka boeona ho litekanyetso tse phahameng le ho fallisoa ha litlamorao tsa sulfonylurea ho hokahaneng le liprotheine,
• valproic acid: ka lebaka la ho fallisoa ha khokahano ea eona le liprotheine,
• NSAIDs
• sulfonamides (ho kenyelletsa Co-trimoxazole),
• barbiturates
• Litlolo tsa lithium.

Lithethefatsi tseo phello ea eona e fokotsehang ka tšebeliso e kopantsoeng le thrombopol:

• sulfinpyrazone, probenecid, benzbromaron le lithethefatsi tse ling tse khahlanong le gout tse eketsang tlhahiso ea uric acid: e amanang le ho felisoa ha uric acid,
• antihypertensive agents, ho kenyelletsa le angiotensin e fetolang li-enzyme tse thibelang,
• aldosterone antagonists (haholo-holo spironolactone),
• loop diuretics (haholo-holo furosemide).

Litšebelisano tse ling:

• joala: tlatsetso
• glucocorticosteroids bakeng sa ts'ebeliso ea kemiso: ho fokolisa ketso ea thrombopol.

Tlhaloso e khutšoane ea lithethefatsi

Thrombo ACC e hlahisoa e le matlapa a manyane a masoeu a chitja a koaheletsoeng ka mochini o benyang o bonolo o qephamang habonolo ka har'a tšilo ea lijo. Bophelo ba sehatsetsing ba moriana ha bo feta lilemo tse tharo, o hloka ho boloka sephutheloana le ona hole le khanya ea letsatsi. Sebopeho sa moriana:

• ntho e sebetsang: acetylsalicylic acid, ho ea ka mahlakore a eona, matlapa a 50 kapa 100 mg,
• likarolo tse thusang.

Moriana o fanoa marang-rang a litlama ntle le lengolo la ngaka. Le ha ho le joalo, e tlameha ho sebelisoa ka hloko le litekanyetso tse khothalletsoang. Li-overdose ha li ratehe haholo ho batho ba tsofetseng.

Phello ea pharmacological ea lithethefatsi e ipapisitse le litšobotsi tsa bohlokoa tsa motsoako oa mantlha - asiti ea salicylic: ho fokotseha ha mekhoa ea ho ruruha, ho fokotseha ha mocheso le phello ea analgesic. Ether ea eona e fokotsa sebopeho sa thromboxane A2 ka liplatelete, ka ho etsa joalo e thusa ho thibela ho thehwa ha methapo ea mali. Phello e iponahatsa hang kamora ts'ebeliso ea Thrombo ACC mme e teng matsatsing a 7 kamora ho nka letlapa le le leng.

Matšoao a ho fana ka meriana

Phello e bonoang ea ketso ea motsoako o ka sehloohong oa lithethefatsi e e lumella hore e laetsoe prophylaxis le kalafo (ka bobeli monotherapy hape e kopantsoe le mekhoa e meng) ea myocardial infarction, ischemia, le varicose veins. Matšoao a sehlooho ao Trombo ACC e laetsoeng ho ona:

• boteng ba angina pectoris,
• prophylaxis ea mantlha le ea bobeli kalafong e rarahaneng ea maloetse a pelo ho tloha ho hlaha ha myocardial infarction, haholo-holo haeba mokuli a fumanoe a e-na le lefu la tsoekere, boima bo feteletseng, litloaelo tse mpe (nikotine le bokhoba ba joala), botsofali bo tiileng,

Ts'ebeliso ea Thrombo ACC hammoho le lithethefatsi tse ling e lumelleha feela kamora lipuisano le ngaka e tlang: matlapa a matlafatsa phello ea karolo e kholo ea litokisetso tsa bongaka (ho kenyelletsa le tse reretsoeng ho phekola pelo), ka lebaka lena, phello ea kalafo e joalo e ka ba e sa lebelloang.

Litaelo bakeng sa tsamaiso e nepahetseng ea Thrombo ACC

Matlapa a lokela ho nooa motšeare kapa mantsiboea, pele ho lijo 'me a hlatsuoa ka metsi a mangata. Thrombo e behiloe joalo ka nete, nako eo e lokelang ho khethoa ke ngaka ho latela lefu lena. Haeba moriana o thusa mme o sa bake matšoao a lehlakoreng, nako ea tsamaiso e ka eketsoa.

Ho noha Trombo ACC ka mpeng e se nang letho ho thibetsoe!

Litekanyetso tse tloaelehileng tsa lithethefatsi ke 50-100 mg ka letsatsi. Litekanyetso tse phahamisitsoeng (ho fihlela ho 200 mg) li laeloa bakeng sa kalafo ea prophylactic ea vein thrombosis e tebileng le thromboembolism.

Setlhare sa lithethefatsi se fumanehang ka seoelo, hobane matlapa a na le ntho e ngata e sa sebetseng.

Ho batho ba botsofe, tšebeliso ea lithethefatsi e ngata e ka baka litlamorao tse ngata tse bohloko:

• ho hloka kelello le tšebelisano ea motsamao,
• ho nyekeloa ke pelo le ho hlatsa haholo,
• bofokoli bo akaretsang
• morethetho oa pelo le khatello e tlase ea mali,
• mosebetsi o sa sebetseng oa renal le hepatic.

Mothating oa ho qala oa overdose, ho lekane ho nka mashala a ts'ebetso, ho hloekisa mpa le ho khutlisetsa chelete e lekanang le motlakase ka meriana le / kapa litlhare. Tabeng ea tekanyo e kholo, ho kenella sepetlele ka potlako ka diuresis, hemodialysis, ho ruruha ha mpa le mala, ho khutlisetsoa tekanyetso ea acid-base le kalafo ea tlhokomelo.

Lingoloa tsa bongaka tsa Thrombo ACC

Thrombo ACC e na le khetho e ngata ea li-analogu, kahoo ho khetha lithethefatsi tse nepahetseng ho latela litšobotsi tsa bona, tsela ea tsamaiso, litekanyetso le litekanyetso tse ka bang teng ha li na ho ba thata.

Ha u nkela Thrombo ACC lithethefatsi tse ling, o lokela ho botsa ngaka ea hau hore e tsamaisane le lithethefatsi tse ling.

Moqapi, foromo ea tokollo, sebopeho, litekanyetso, litlhaloso

Thrombo ACC e hlahisoa ke k'hamphani ea meriana ea Austrian GL. Pharma GmbH, eo limela tsa eona li leng toropong ea Pannach. Naheng ea Russia, moemeli oa litsebi tsa meriana ea Austrian ke k'hamphani "Valeant", e fumanehang atereseng: 115162, Moscow, st. Shabolovka, ntlo ea 31, moaho 5. Ke atereseng ena moo o ka romellang likopo tsohle mabapi le lithethefatsi.

Thrombo ACC e fumaneha ka foromo e le 'ngoe ea litekanyetso - eona matlapa a molomoenteric koaetsoeng mafome. Matlapa a na le lilakane (konvalyutki) tse entsoeng ka aluminium le polyvinyl chloride, tseo, 'me li kenngoa ka mabokoseng a karete le pampitšana e nang le litaelo tsa tšebeliso. Mabokoseng - matlapa a 14 kapa 20.

Matlapa a Thrombo ACC a na le acetylsalicylic acid e le motsoako o sebetsang, o tsejoang haholo e le Aspirin. Empa ho fapana le Aspirin ea khale ka phello ea antipyretic le analgesic, sebopeho sa Trombo ACC se na le acetylsalicylic acid ka tekanyo e tlase haholo, e e fang litekanyetso tse fapaneng hanyane, e leng, antiplatelet effect. Kahoo, matlapeng a Thrombo ACC, asiti ea acetylsalicylic e fumaneha ka litekanyetso tse peli - 50 mg kapa 100 mg. Litekanyetso ka bobeli li tlase, ka hona, moriana o ka sebelisoa feela, joalo ka ha batho ba re, "ho fokotseha madi", mme ha se ho kokobetsa bohloko le ho fokotsa mocheso o phahameng oa 'mele. Ehlile, haeba u lakatsa, u ka sebelisa Thrombo ACC ho theola mocheso, empa bakeng sa sena o tla tlameha ho nka matlapa a mahlano hang hang, a lekanang le tekanyetso e le 'ngoe ea "Aspirin" e tloaelehileng. Sena ha se na thuso ebile se kotsi.

Empa ho nka sebaka sa Trombo ACC ka Aspirin e tloaelehileng ho ka etsahala, kaha ntho e sebetsang e tšoana. Empa ke maemong ana feela letlapa la Aspirin le tla tlameha ho aroloa ka likarolo kapa bophahamo ho fumana litekanyetso tsa acetylsalicylic acid ho 50-100 mg.

E le likarolo tse thusang, matlapa a nang le litekanyetso tsa 50 mg le 100 mg a na le lintho tse tšoanang: cellcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide le starch ea litapole. Khetla ea matlapa a 100 mg le 50 mg le eona e na le lintho tse tšoanang, e leng: talc, triacetin, kopolymer ea methaconic acid le ethyl acrylate (1: 1) (Eudragit L).

Matlapa a litekanyetso ka bobeli (50 mg le 100 mg) ka boeona a pentiloe a tšoeu, a na le sebopeho sa biconvex, 'mala o boreleli kapa o bokhutšoaane hanyane.

Thrombo ACC 100 le 50

Khafetsa, puong ea letsatsi le letsatsi, bakeng sa bonolo, lipalo li eketsoa mabitsong a lithethefatsi tse bolelang litekanyetso tsa ntho e sebetsang. Kaho e joalo ea "mabitso" a macha e amoheloa ka kakaretso, ka hona litsebi tsa meriana, lingaka le bakuli le bona baa li utloisisa. Sena se sebetsa ka botlalo ho Thrombo ACC, ha mabitso a macha "Thrombo ACC 100" le "Thrombo ACC 50" a bolela feela litekanyetso tsa matlapa a moriana o le mong.

Ha ho na phapang, ntle le litekanyetso tsa ntho e sebetsang, lipakeng tsa Thrombo ACC 50 le Thrombo ACC 100, ka hona re ke ke ra nahana ka moriana o le mong ka thoko le litekanyetso tse fapaneng. Ho fapana le hoo, temaneng e ka tlase, tlhaiso-leseling eohle e fuoeng e tla ama Thrombo ACC ka nako efe kapa efe - 50 mg le 100 mg. Haeba ho hlokahala ho totobatsa matšoao kapa likarolo tse itseng tsa litekanyetso tse itseng, re tla e etsa ka sepheo, empa ho seng joalo tlhaiso-leseling eohle e tla ama Trombo ACC ka litekanyetso ka bobeli.

Phello ea kalafo

Thrombotic ACC e na le phello ea antiplatelet, e kenyang ho fokotsa ho khomarela ha liplatelete le lisele tse khubelu tsa mali. Ho feta moo, khokahano ea likarolo tsa mali e theotsoeng e fokotseha ka bo bona le ka lerako la methapo ea mali. Ka lebaka lena, mali a fetoha metsi haholo, eseng joalo ka viscous, a bonolo ebile a potoloha hantle ka har'a lijana, ha a thekesele, ha a thehe marang-rang. Matla a antiplatelet a Thrombo ACC ka lebaka la ntlafatso ea mali a phallang a boetse a thibela ho etsoa ha methapo ea mali methapong e fapaneng, eo, e thusang ho thibela maemo a fapaneng a tebileng a bakoang ke ho phatloha ha methapo ea mali ke methapo ea mali (ho otloa ke pelo, stroke, thromboses, pulmonary embolism, jj.).

Acetylsalicylic acid, eo e leng karolo ea Thrombo ACC e le motsoako o sebetsang, hajoale ke e 'ngoe ea li-antiplatelet tse sebelisoang haholo. Phello ea eona ea antiplatelet e na le mekhoa e mengata. Kahoo, asiti ea acetylsalicylic e ama mosebetsi oa li-enzyme tse fapaneng tse ntlafatsang tlhahiso ea lintho tse ling le ho thibela tse ling.

Ntle le phello ea antiplatelet, acetylsalicylic acid e boetse e na le phello ea fibrinolytic, e kenyang ho qhibiliha ha methapo ea mali e seng e ntse e thehile le ho hlapolla lisele tse khubelu tsa mali. Acetylsalicylic acid e boetse e fokotsa bongata ba lintho tse kopaneng II, VII, IX, le X maling, tseo hape li fokotsang sebopeho sa thrombus.

Bakeng sa nts'etsopele ea ts'ebetso ea fibrinolytic le antiplatelet, asiti ea acetylsalicylic e nkoa ka tekanyetso e tlase - 75 - 325 mg ka letsatsi. Ke ka lebaka leo matlapa a Trombo ACC a nang le 50 mg feela kapa 100 mg ea acetylsalicylic acid. Matla a antiplatelet a phehella beke ka mor'a tekanyetso e le 'ngoe ea Thrombo ACC.

Ke thepa e hlalositsoeng ea acetylsalicylic acid e sebelisetsoang ho thibela le ho phekola lefu la pelo, lefu la pelo, mathata a methapo ea varicose le mafu a mang a kotsi bakeng sa ho etsoa ha methapo ea mali.

Ha ho nkuoa thrombo, ACC e ananeloa kapele le ka botlalo. Ka lebaka la ho koahela ka enteric, letlapa ha le na ho khopisa le ho senya kamong ea hau ea gastric. Kamora ho kenella maling, acetylsalicylic acid e fetoha acid e salicylic, e fanang ka phello. Ho feta moo, salicylic acid ha e nke lehlakore ka har'a sebete ka sebopeho sa phenyl salicylate, salicylate glucuronide le salicyluric acid, eo, 'me e fetisetsoa ho litho tsohle le lisele. Asalliclic acid e fetela lebese la matsoele 'me e feta ka har'a placenta. Ho basali, phetoho ea asiti ea acetylsalicylic 'meleng e tsamaea butle ho feta ho banna ka lebaka la lebelo le tlase la li-enzyme.

Acetylsalicylic acid e pepisoa ka sebopeho sa metabolites ke liphio nakong ea lihora tse 24 ho isa ho tse 72. Le ha ho etsoa taolo khafetsa, sethethefatsi ha se bokelle serumong ea mali.

U ka e nka joang?

Matlapa a Thrombo ACC 50 mg le 100 mg a lokela ho nooa hang-hang pele ho lijo, a hlatsoe ka metsi a mangata - bonyane khalase (200 ml). Hopola hore u ke ke ua noa Thrombo ACC ka mpeng e se nang letho, kaha sena se ka u utloisa bohloko le ho opeloa ke mpa. Etsa bonnete ba hore hang-hang o ja kamora thrombotic ACC. Ka nako e ts'oanang, poleloana "ja" ha e bolele lijo tsa mots'eare tse thata, empa tšebeliso ea lijo tse fokolang tse tla tlatsa mpa. Mohlala, kamora ho nka Thrombo ACC ho lekane ho ja libanana tse mmaloa, sandwich, palo e nyane ea porese, salate, jj., Mme sena se tla lekana ho thibela phello e halefisang ea lithethefatsi ka mpeng.

Matlapa a Trombo ACC ka boeona a lokela ho metsoa ka botlalo, eseng a sithabetse, a hlafuna, a hateletsoe kapa a hatelloa ka tsela e 'ngoe.

Ha e le molao, thrombo ACC e nkuoa hang ka letsatsi ka tekanyetso e kholo ea letsatsi le letsatsi. Ho bohlokoa ho nka moriana ka letsatsi ka nako e tšoanang - bakeng sa sena o hloka feela ho khetha ntlha e itseng mots'eare mme o noe moriana ka nako ena kaofela. Ho bonolo hore batho ba bangata ba nke Thrombo ACC pele ho lijo tsa hoseng, ha ba bang ba rata ho etsa sena mantsiboea pele ba robala. Nako ea ho nka litafole e itšetlehile ka ho felletseng ka bonolo ba mokuli. Empa ho lokela ho hopoloa hore nako le nako ha moriana o noele, hang ka mor'a moo o hloka ho ja lijo tse fokolang.

Matlapa a Thrombo ACC a etselitsoe tšebeliso ea nako e telele, 'me nako e itseng ea lithuto tsa kalafo e reriloe ke ngaka. Motho e mong o fuoe tšebeliso e tsoelang pele ea Thrombo ACC ka likhoeli tse tšeletseng kapa esita le lilemo tse 'maloa,' me motho e mong o fuoa likhoeli tse tharo le khefu ea libeke tse peli ho isa ho tse nne lipakeng tsa bona. Kamora ho ts'ebetso, Thrombo ACC e ka khethoa khoeli feela. Empa ka kakaretso, hangata ho latela Trombo ACC e laeloa bophelo bohle, hobane haeba motho a le kotsing ea ho tšoaroa ke lefu la thrombosis le ho koaloa ha methapo e fapaneng ea methapo ka nako eo, ha a sa hlola a nyamela mme o sala a le teng. Ke ho thibela ho thehwa ha methapo ea mali le ho thijoa ha methapo ea mali e bitsoang thrombo ACC e nkuoa nako e telele, ntle le hore, ho joalo, motho o kotsing e kholo ea thrombosis.

Melemo ea maloetse a fapaneng

Tekanyetso ea thrombotic ACC e itšetlehile ka hore na hobaneng moriana o nooa.

Kahoo, bakeng sa thibelo ea infarction ea myocardial ea mantlha le e pheta-phetoang, Thrombo ACC e lokela ho nkuoa 50-100 mg ka letsatsi (1 kiba 50 50 mg kapa 1% 100 mg hang ka letsatsi).

Ha phekolo ea angina e sa tsitsang le e tsitsitseng, thrombo ACC e khothalletsoa hape ho nka 50-100 mg ka letsatsi. Ka hona, o hloka ho noa letlapa le le leng la 50 mg kapa 100 mg hang ka letsatsi.

Bakeng sa thibelo ea ho ba le likotsi tsa lefu la ho ferekana le ho fokola ka nakoana, Thrombo ACC e khothalletsoa ho nka 50-100 mg ka letsatsi (1 kiba 50 mg mg kapa 1% 100 mg hang ka letsatsi).

Thibelo ea thromboembolism ka mor'a ts'ebetso leha e le efe ea ho buuoa le ka mor'a ho kenella ha methapo ea methapo e kenyelletsa ho nka Thrombo ACC ho 50 - 100 mg ka letsatsi (1 Letlapa la 50 mg kapa Letlapa le le leng la 100 mg hang ka letsatsi).

Ho thibela vein thrombosis e tebileng le thromboembolism ea methapo ea methapo ea methapo le makala a eona, Thrombo ACC e khothalletsoa ho nka 100-200 mg ka letsatsi (matlapa a 1 kapa a mabeli a 100 mg hang ka letsatsi).

Sebelisa nakong ea bokhachane le nakong ea matsoele

Ts'ebeliso ea acetylsalicylic acid nakong ea likhoeli tse tharo tsa pelehi e ka tsosa likoli tsa nts'etsopele ka popelong, joalo ka kharafu e holimo e arohaneng ("cleft palate"), bofokoli ba pelo, jj. Ke ka lebaka leo ho nwa meriana e nang le acetylsalicylic acid, ho kenyeletswa le Thrombo ACC, e kopantsoeng hantle le hara libeke tse leshome le metso e meraro tsa pelehi.

Ho nka litokisetso tsa acetylsalicylic acid ho litekanyetso tse fetang 300 mg ka letsatsi ho tloha bekeng ea 27 ea boimana le pele ho hlaha ho baka tšitiso ea pelehi, ho eketseha ha mali ho mme le ka popelong, hammoho le ho kopanngoa ha pelo ho sa le lesea. Ho amohela li-acetylsalicylic acid hang hang pele li tsoala ho ka baka maloetse a mosesaane ho lesea le sa tsoa hlaha, haholoholo haeba lesea le sa tsoa hlaha. Ke ka lebaka leo ho nka lithethefatsi leha e le life ka acetylsalicylic acid ho trimester ea boraro ea bokhachane e thibetsoeng.

Nakong ea trimester ea bobeli ea bokhachane, ho tloha ka la 14 ho isa ho la 26 beke, ho kenyeletsoa, ​​Trombo ACC e ka nkuoa feela ka lipontšo tse hlakileng, ha ho le bohlokoa ho mme ea lebelletsoeng, mme haeba phaello e feta likotsi tsohle tse ka bang teng. Nakong ea trimester ea bobeli ea boimana, ts'ebeliso ea thrombo ACC lithutong tse khutšoane e lumelletsoe.

Acetylsalicylic acid le lihlahisoa tsa eona li fetela lebeseng. Empa tsamaiso ea ka phoso ea acetylsalicylic acid hangata ha e bake litlamorao kapa mathata ho masea, ka lebaka la hore ke "thrombo ACC" nakong ea kanyeso e lumelloang. Leha ho le joalo, haeba Trombo ACC e nkuoa nako e telele, joale ho anyesa ho ntse ho le molemo ho hlakola le ho fetisetsa ngoana ho metsoako ea maiketsetso.

Ho sebelisana le lithethefatsi tse ling

Thrombotic ACC, ha e sebelisoa hammoho, e ntlafatsa litlamorao tsa lithethefatsi tse latelang:

• Methotrexate (e fokotsang excretion ea methotrexate ke liphio),
• Li-anticoagulants (Heparin, Warfarin, joalo-joalo), thrombolytics (Urokinase, Fibrinolysin, jj) le li-antiplatelet agents tse ling (Clopidogrel, Curantil, jj.). Ha e nkuoa ka Trombo ACC, litlamorao tse senyehang ho mucous membrous ea mala le mala li eketseha, mme menyetla ea ho tsoa mali e eketseha,
• Khetho ea serotonin reuptake inhibitors (Fluoxetine, Venlafaxine, Elicea, Valdoxan, Flunisan, Oprah, jj) - menyetla ea ho tsoa mali ho tsoa mpeng le esophagus e eketseha,
• Digoxin - mantle a eona a liphio a fokotsehile, a ka lebisang ho overdose ea hae,
• Liphetho tsa sulfonylureas ho fokotsa tsoekere ea mali (Glibenclamide, Glycvidone, Glyclazide, Glimepiride, Glipizid, Chlorpropamide, Buformide, Nateglimide, jj.) - boemo ba glucose bo ka fokotseha haholo, kaha Thrombo ACC le eona e fokotsa tsitsipano ea eona,
• Litokisetso tsa Valproic acid (Konvuleks, Depakin, Dipromal, Valparin XP, jj.) - chefo ea boleng bo phahameng ea valproate,
• Lino tse thehiloeng tahi le lithethefatsi tse thehiloeng ho joala - menyetla ea ho senya mucous ea mucous ea mala le mala ea eketseha, 'me nako ea ho tsoa madi e boetse ea lelefatsa,
• Lithethefatsi tse seng khahlanong le ho ruruha (Diclofenac, Nimesulide, Indomethacin, Meloxicam, jj) le li-salicylates tse ling (Salofalk, jj.) - kotsi ea ho ba le liso tsa ka mpeng le liso tsa duodenal le mali a eketseha.

Tšebeliso e tšoanang ea Thrombo ACC le lithethefatsi tse latelang e fokotsa ts'ebetso ea bona (ka hona, keketseho ea litekanyetso tsa bona e ka hlokahala):

• Lithethefatsi life kapa life tsa diuretic (tlasa tšusumetso ea Thrombo ACC, sekhahla sa ho hlohlona ha urine ka liphio sea fokotseha),
• Inhibitors ea angiotensin-converting enzyme (Captopril, Kapoten, Perineva, Prenessa, Enalapril, jj.) - litlamorao tsa li-inhibitors tsa ho theola khatello ea mali li fokola mme phello ea bona ea cardioprotective e hlahisoa. Ka tloaelo, ho fokotseha ha botebo ba ketso ea li-inhibitors tsa angiotensin ho bonoa ha li nkuoa hammoho le Thrombo ACC ka tekanyo ea limilimithara tse fetang 160 ka letsatsi,
• Lithethefatsi tse ntlafatsang tlhahiso ea li-uric acid (Probenecid, Benzbromaron) - phello ea tsona ea fokotseha ka lebaka la ho lieha ha liphio,
• Lihormone tsa "systemic glucocorticoid" (prednisone, dexamethasone, jj) - tlhahiso ea thrombo ACC e matlafatsoa haholo, mme phello ea bona ea fokola.

Litlamorao

Thrombo ACC hangata e mamelloa hantle mme, ka lebaka la litekanyetso tse tlase tsa acetylsalicylic acid, ha e bake litla-morao. Leha ho le joalo, maemong a sa tloaelehang, thrombo ACC e ntse e ka tsosa nts'etsopele ea litlamorao tse fapaneng tse tsoang ho litho le litsamaiso tse fapaneng:

1. Ho tsoa pampiring ea ka mpeng:

• Nausea
• Ho phomola
• Ho opeloa ke pelo
• Bohloko ba ka mpeng
• Ulcerth kapa ulodenal ulcer,
• Ho tsoa mali ka mpeng
• Ts'ebetso ea sebete ea nakoana e senyehileng ka ts'ebetso e eketsehileng ea aspartate aminotransferase (AcAT) le alanine aminotransferase (AlAT).

• Tsietsing
• Ho utloa ts'oaetso
• Tinnitus.

• Sekhahla se phahameng sa ho tsoa mali nakong le ka mor'a ho buuoa,
• Ho hlaha ha hematoma khafetsa,
• Khafetsa nko
• Meno a tsoang mali
• Ho tsoa mali
• Cerebral hemorrhages (ho na le kotsi e kholo ho bakuli ba nkang Warfarin kapa li-anticoagulants ka nako e le 'ngoe, kapa ba sa laole khatello ea mali, empa hangata e phahama),
• Anemia e haelloang haholo kapa e sa foleng ea khaello ea mali kapa khaello ea tšepe ka lebaka la ho tsoa mali.

• Letlalo la letlalo
• Letlalo le makatsang
• Urticaria,
• Kholo ea Quincke,
• Allergic rhinitis
• Ho ruruha ha mucosa ea ka mpeng:
• Bronchospasm (ho koaloa ka thata hoa lumen ea bronchi ka ho ba teng hoa maikutlo a ho thulana),
• Cardio-respiratory khatello ea maikutlo,
• Ho thothomela ha anaphylactic.

Mokhoa oa ho nka thrombo ACC - pele o ja kapa ka mor'a lijo?

Kamora ho etela ngaka, mokuli o fumana lebitso le lecha la moriana lethathamong la ngaka. E latelang, hangata, ho fanoa ka maikutlo a makgutshwanyane, ho tlaleha tekanyo ea tekanyetso e le 'ngoe ea moriana, e ata ka palo ea litekanyetso ka letsatsi. Maemong a mang, tlhaiso-leseling ena e lekane, empa eseng feela ha o hloka ho nka TromboASS.

Ho joalo, o ka bona ho litaelo tsa ho nka matlapa a Thrombo ACC bakeng sa tšollo ea mali, kamehla ho na le karolo - "mokhoa oa ts'ebeliso", e bonts'a hore na o etsa sena neng pele ho lijo kapa ka mor'a lijo. Empa eseng ho nyelisa li-compilers, taeo e joalo e etselitsoe moahi ea tloaelehileng ea sa pheleng. Ka mor'a moo, ho latela lenane la likhokahano moo motho e mong le e mong a fumanang bonyane "e ngoe" ea hae.

Kamora moo, litletlebo mabapi le ho se tsotelle, esita le ho se tsotelle ha ngaka e eang, lia qala. Habohlokoa ka ho fetesisa ke "li-ventricles", 'me ka boithatelo li fetohela ho li-analogu tse se nang li-acid.

Joale ke mang ea phoso? Ngaka? Kapa setsebi se ngotseng tokomane e tsamaeang le moriana oo? Karabo e ka fumanoa ka ho lebisa litaelo tse karolong e hlalosoang ka ho qaqisa letlapa le le leng.

Ho kenyeletsoa eng ho lokisoeng ha thromboass?

Peresente e ka sehloohong ea moriana ona, ehlile, ke acetylsalicylic acid. Sena ke seo bakuli ba nang le lefu la gastritis le liso tsa ka mpeng ba sa se amohele.

Empa ha rea ​​lokela ho lebala hore, ho fapana le ASK e tloaelehileng e rekisoang khemising, matlapa a tšelang mali a TromboAX a koahetsoe ka khetla eo ho eona likarolo tse kang talc le eudragit li leng teng.

sc lebitso = "info2 ″ mongolo =" Ka boholo ba limolek'hule ea talc, eo e leng karolo ea khetla, ho na le magnesium - ntho e khelosang phello e senyang ea ASA ho epithelium ea mpa. "

Li-Eudragits li tsoa ho polymerization ea acrylic acid. Ba etsa mesebetsi ea ho isa sethethefatsi karolong e itseng e boletsoeng esale pele ea mala, ba e sirelletsa litlamorao tsa acid ea mala le ho monya kapele.

Empa, ho ntse ho hlokahala hore ho hatisoe ka litlatsetso. Ena ke "ketsahalo e" insured "ha mokuli a fositse" eseng ka mpeng e se nang letho "le" ntle le ho hlafuna ", a feta" ka hloko "mme" a sa khothalletsoa. ​​"

Fomu ea tokollo, sebopeho le sephutheloana

Matlapa a enteric a koahetsoeng ka enteric, a 'mala o pinki ka' mala, a na le motsoako o sebetsang o bitsoang Acidum acetylsalicylicum. Ho latela lipatlisiso tsa Trombopol, setlhare se nang le sebopeho se chitja se hlahisoa ka tekanyetso e latelang - li-milligram tse mashome a supileng a metso e mehlano le tse lekholo le mashome a mahlano. Joaloka lisebelisoa tse thusang, moetsi o sebelisa starch ea poone, MCC, atria amylopectin glycolate. Khetla ena e na le likarolo tse 'maloa - Hypromellosum, motsoako o khethehileng bakeng sa ho koahela moriana le E553b, tlatsetso ea lijo E171, triethyl citrate, taba ea mebala, Silicii dioxydum colloidale, Natrii hydrocarbonas, sodium lauryl sulfate. Theko e tloaelehileng ea Trombopol ke li-ruble tse 51. Tlhahisoleseling mabapi le ho fumaneha ha moriana o ka fumanoa ka mohala kapa webosaeteng ea mofani oa semolao.

Ha u phatsima ka tlasa khetla, u ka bona hore ntle le ACS, sebopeho sa ntho e sebetsang se kenyeletsa:

• lactose
• selulose
• silicon
• litapole tsa litapole.

Lactose e theha sebaka sa ho ikatisa sa lactobacilli, e tsitsitseng sebopeho sa microflora ea mala. Cellulose e hloekisa mala. Silicon e tlama le ho tlosa bilirubin 'meleng, ka tsela eo e thelle mali. Litapole starch lowers acidity le eketsa boits'ireletso.

sc lebitso = "info2 ″ mongolo =" Ka tlhaho, litaba tsa lintho tsena ka har'a letlapa le le leng li nyane. Empa ka lebaka la hore sethethefatsi se laetsoe, e le molao, nako e telele, se akaretsoa se akaretsoa 'me se se ntse se bohlokoa. ”

Ha re se re hlakisitse morero oa likarolo tsohle tsa moriana, re khutlela potsong ea mantlha. Ho nka thromboass, hona na ho bohlokoa haholo hore na u noe lipilisi neng - pele le ka mor'a lijo?

Na phello e fokotsang ea lipilisi e itšetlehile ka bongata, boleng le nako ea lijo?

Phuputso e entsoeng mabapi le makasine ena e bontšitse:

1. Karolo e ka sehloohong ea ASA e kenella ka mpeng e nyane, kapa ho fapana le moo, karolong ea eona e kaholimo.
2. Nako ea ho monya ha e ea itšetleha ka tekanyo ea botlalo ba mpa.
3. Li-antidid tse fokotsang acidity ea lero la gastric ha li ame lebelo leo moriana o khothalletsoang ke moriana. Ho ka buuoa se tšoanang ka lebese le lihlahisoa tse ling tse nang le mafura a liphoofolo.

Hape, re sheba litaelo, moo ho thoeng matlapa a Thrombo ACC a lokela ho nooa pele ho lijo, empa eseng ka mpa e se nang letho. Le taba ea hore lijo ha li kena-kenane le ts'ebetso ea lithethefatsi, e hlophisitsoe.

Re ntse re utloisisa hore na ho thoe'ng eseng ka mpeng e se nang letho?

Se ke oa nooa matlapa hang kamora ho robala. Mala a boetse a hloka nako hore a be le tšebetso. Haeba, ka lebaka le itseng, halofo ea pele ea letsatsi ke khetho e ntle ka ho fetisisa ea ho nka meriana, joale u lokela ho ja ho hong. E tlohelle e be sengoathoana sa lijo, empa e tla fana ka mpa e le taelo - "ho qala".

Thromboass bakeng sa tšelo ea mali, e nkiloeng "ka mpeng e sa thekeseleng," ntle le lijo tse tlang, e ka ba kotsing ea ho qhibiliha ka mpeng. Ka acidity e eketsehileng ea tikoloho, karolo e ka sehloohong ea ASA e tla lula e le tharollo ea asiti, e matlafatse phello e khopisang lisele tsa epithelial. Ka acidity e fokotsehileng ea mpeng, ASA e kenella ka har'a mabota a motsoako oa lijo 'me ea bokellana liseleng tsa membrane ea mucous, eo ho hang e seng e lakatsehang.

sc name = "info" text = "U hloka ho nka Tromboass sebakeng se bohareng, se ke keng sa boleloa hore ke" kamora ho ja ", kapa" pele. "

Joalo ka ha o ka utloisisa, litataiso tsena kaofela li amana, boholo ba tsona, le ts'ireletso ea ts'ilo ea lijo, ho tsoa litlamong tse mpe tsa ASA, mme ha li ame phello e fokotsang ea lithethefatsi.

Motho ea fokolang mali o sebetsa joang?

Lintho tse sebetsang tsa sehlahisoa li kenelletse ka har'a maboteng a mala a manyane. ASA e khetholloa ka ho beoa kantle ho lisele. Empa hape e amahanngoa le protheine, ha e lahleheloe ke ts'ebetso ea eona.

ASA e thusa hore ho be le thromboxane - enzyme e patiloeng ke liplatelete tse qotsitsoeng, tse sebetsang e le lets'oao la ts'ebetso ea liplatelete tse ling. Li-platelet tse sa sebetseng, ho fihlela qetellong ea bophelo ba tsona, li lahleheloa ke bokhoni ba ho ikopanya, bo thusang ho theola mali.

Thepa e khahlisang ea ASA e fumanehang ka har'a moriana ke hore moriana o kanna oa se ke oa fumanoa ho hang ka plasma ea mali (kapa e fumanoe ka tekanyo e nyane haholo). Empa, leha ho le joalo, phello ea inhibitory ts'ebetsong ea liplatelete e tla bonahatsoa ka botlalo.

sc lebitso = "info" mongolo = "Ho kenngoa ka har'a lisele tsa sebete, ASA e theha" ambulla "liphatlalatsaneng mona. "Tsamaiso ea potoloho e li tsamaisa mona, moo li pepesetsoang tekanyetso e felletseng ea moriana."

Khahlano le nalane ea ho fokotseha hoa boemo ba "thromboxane", "litaba tsa" prostacyclin, 'me e le mohanyetsi oa ts'ebetso ea liplatelese e nyoloha maling. Kahoo, sephetho se hlokahalang le se lebelletsoeng sea phethahala - ho fokotseha ha mali.

Kaha ho khothalletsoa ho nka Thrombo ACC ho theola mali, ho hlatsoa matlapa ka metsi a mangata kapa metsi a mang, sena se hlokomela motsotso oa ts'ebetso - pele ho lijo, eseng kamora ho ja. Lijo, tse nang le mokelikeli o mongata oa mokelikeli, li thatafatsa mosebetsi oa mala le ho lula ho lona nako e telele.

E le molao, ngaka e beha tekanyetso e le 'ngoe ea moriana, ka tlhahiso ea mantsiboea. Ho sena, motho ha a lokela ho sheba litšepiso leha e le life tse patiloeng ho biorhythms ea 'mele kapa mabaka a mang a sepheo.

Motsotso oa mantsiboea, pele ho lijo tsa mantsiboea, o bohlokoa ho feta ponong ea kelello. Ena ke nako eo ka eona matšoenyeho a mots'eare, ho potlakisa, lefeela li seng li felisitsoe. Mmele, ho kenyelletsa le boko, o fumana karohano e khutšoane ho tsoa ho tse tšoenyehileng tsa kantle mme o khona ho tsepamisa mohopolo. Ona ke boemo bo bonolo haholo ba ho sebelisa lipilisi hantle.

sc lebitso = "info2 ″ mongolo =" Ha feela tatellano eohle e ka bonoa, lithethefatsi li ke ke tsa ba le litlamorao tse mpe mmeleng feela, empa lihlahisoa tsohle tse bolileng li tla tlosoa ka katleho. "

Haeba mokuli a na le lipelaelo mabapi le bohlokoa ba moriana oo. Haeba nakong ea kalafo matšoao a bohloko a hlaha ka mpeng, ho nyekeloa ke pelo, ho tsekela, ho felloa ke matla. U lokela ho ikopanya le ngaka ea hau hanghang.

Ntle le moo, ha ua lokela ho ikemela ho fetola litekanyetso tsa lithethefatsi kapa ho ikemisetsa ho nka sebaka sa ThromboASS ka li-analogues. Hona ke tokelo ea lingaka tse nang le tlhaiso-leseling e mabapi le boemo bo akaretsang ba 'mele oa mokuli, bo hlophisitsoeng motheong oa tlhahlobo le tlhahlobo, ho nka lintlha tsohle tse kotsing.

Ketso ea pharmacological

Boithuto ba kliniki bo bontšitse hore, joaloka li-analogues tsa bona, thrombopol e kenella ka botlalo setsing sa tšilo ea lijo. Acidum acetylsalicylicum e na le thepa ea ho fetoloa mofuta oa acid. Palo e phahameng ea acetylsalicylic acid e plasma ea mali e tlalehiloe ka karolelano ea metsotso e leshome le metso e mehlano ka mor'a ho nka moriana, metabolite e sebetsang e fihla maemong a phahameng ka nako ea metsotso e mashome a mararo ho isa ho e mashome a mabeli. Ka lebaka la botsitso bo eketsehileng ba khetla ea khalase, ho lokolloa ha sethethefatsi se sebetsang ho hlaha ka mpeng. Thepa ena ea rona e kenya letsoho ho amoheng ntho e ntseng e lietsahala - ho tloha metsotso e 180 ho isa ho ea 360. Karolo e sebetsang le metabolite ka bobeli li na le thepa ea ho tlama liprotheine tsa plasma. Hape, lintho tse thathamisitsoeng li tšoauoa ka ho tsamaisoa ka potlako lithong. 2-hydroxybenzoic acid e na le thepa ea ho chekeloa lebese la matsoele. Liphetho tsa liteko li bonts'a hore metabolite e kenella ka har'a sekhahla sa placental. Tlhahiso ea eona e itšetleha ka tekanyetso e boletsoeng. Ka tekanyo e tlase ea lithethefatsi, halofo ea bophelo e nka ho tloha metsotso e 120 ho isa ho e 180. Ka tekanyo e phahameng, T1 / 2 ke lihora tse leshome le metso e mehlano. Motsoako oa asene e nang le letsoai o hlaha haholo ka liphio. O ka odara thrombopolla hole. Karolo e sebetsang e na le thepa e latelang: • inhibits pokello ea liplatelete, • e sitisa motsoako oa thromboxane A2. Ho boetse ho na le litlhahiso tsa mekhoa e meng ea ho sebetsa Acidum acetylsalicylicum ka lipokothong tsa sethala, ka hona ntho ena e sebelisoa ka mafolofolo ho phekola mathata a methapo a methapo. Li-NSAID li har'a tsona, 'me acetylsalicylic acid e na le phello e rarahaneng: • e kokobetsa bohloko, • e fokotsa mocheso, e tlosa ho ruruha. Ho na le karolo e kholo ea karolo e sebetsang, joalo ka ha ho hlalositsoe tlhaloso, e sebelisoa bakeng sa tšoaetso ea vaerase e matla ea phefumoloho, hammoho le ntaramane ho sitisa matšoao a latelang: le ankylosing spondylitis.

Thrombopol, joalo ka ha ho laetsoe ke litaelo, e fuoe bakuli ba nang le mafu a latelang: • angina pectoris ea sehlopha se sa tsitsang, • e le prophylaxis ea stroke, haholo ho bakuli ba nang le mathata a ho potoloha ha boko, ka sebopeho sa nakoana, E 'ngoe ea lisosa tse bakang - lefu la tsoekere, khatello e phahameng ea mali, litloaelo tse mpe, ho kenyelletsa ho tsuba, ho bakuli ba sehlopha sa batho ba baholo (ho tloha ho lilemo tse 65), dyslipidemia, linyeoe tse phetoang tsa MI, • prolact ka-hlobaetsang blockage ea sejana se mali ke thrombus e, ho roba hole le sebaka sa tsona ba thuto, haholo-holo ka mor'a ho buoa kapa itaolang vascular, embolism methapo • thibelo, • ho thibela mafu a hlobaetsang le-ho qala ka boko mosebetsi se hlahang ho yona vascular, o ile a bontša tsepamiso, bokong kapa tsoakiloeng matšoao.

Tekanyetso le tsamaiso

Trombopol ke ts'ebeliso ea molomo. Moetsi o khothaletsa ho nka moriana o le mofuta oa letlapa kamora lijo, ntle le ho senya botsitso ba ona. Tekanyetso, hammoho le mofuta oa kalafo, o ikemiselitsoe ho latela nalane ea mokuli le ho teba ha lefu lena: 1. Haeba motho a belaela MI karolong e mpe haholo, ho tloha ho millione tse lekholo le mashome a mahlano ho isa ho tse tharo tsa ntho e sebetsang e boletsoe. Moetsi o khothalletsa ho hlafuna letlapa la pele ha matšoao a pele a hlaha. Ho senyeha ha membrane ea enteric ho tla potlakisa phello ea lithethefatsi. Ho feta khoeli e tlang, bakuli ba lokela ho nka li-milligram tse 75 ho isa ho tse 300 ka letsatsi. Kamora 'kalafo e joalo ea kalafo, ngaka e eang e lokela ho nahana ka tlhoko ea ts'ebetso e eketsehileng ea moriana, ho thibela linyeoe tse ncha tsa lefu lena. Bakeng sa bakuli ba fetileng MI, ho fokotsa kotsi ea ho fokolloa ke bophelo le phello e ka bang teng ea ho bolaoa, palo ea meriana e boletsoe ka har'a li-milligram tse 75-300. 3. Ka mofuta o bitsoang angina pectoris oa mofuta o tsitsitseng le o sa tsitsang, o tla hloka ho tloha ho li-milligram tse mashome a supileng a metso e mehlano tsa thepa e sebetsang ka letsatsi. 4. Bakuli ba kotsing ea ho holisa matšoao a MI ka sebopeho se matla le lefu la tsoekere, khatello e phahameng ea mali, botenya, hape le botsofaling ba khothalletsoa ho nka li-milligram tse lekholo le mashome a mahlano tsa karolo e sebetsang ka letsatsi kapa li-milligram tse makholo a mararo ka letsatsi le leng. 5. Ho thibela tsoelo-pele ea bobeli ea setorouku, o tla hloka limilione tse mashome a supileng a metso e mehlano ho isa ho tse makholo a mararo tsa karolo e sebetsang mots'eare. 6. Sekhahla se tšoanang sa letsatsi le letsatsi se sebelisetsoa ho phekola bakuli ba nang le matšoao a lefu la nakoana la ischemic, hammoho le boemo bo kopaneng ba seteraeke le ho koala sekhahla se kobehileng sa mokokotlo oa mali ke thrombus e khaohileng sebopeho sa eona kamora lits'ebetso tsa ho buoa le tse hlaselang. 7. O ka thibela DVT le thromboembolism le Trombopol ho litekanyetso li-milligram tse 75 ho isa ho tse 200 ka letsatsi. Mokhoa o mong oa kalafo o boetse oa lumelloa, o sebelisa li-milligram tse makholo a mararo letsatsi le leng le le leng. E abele, e le molao, ka mor'a ho buuoa haholo. Bakeng sa bakuli ba nang le ts'ebeliso e tloaelehileng ea liphio le sebete ka mokhoa o bonolo le o leka-lekaneng, ho ka hlokahala phetoho ea litekanyetso tsa moriana.O ka reka Trombopol ho leqhubu la mabenkele la meriana le li-agency tsa inthanete.