Lizoril - (Lisoril) litaelo tsa tšebeliso

Tlhaloso e amanang le 28.12.2014

• Lebitso la Latin: Lisinopril
• Khoutu ea ATX: C09AA03
• Lintho tse sebetsang: Lisinopril (Lisinopril)
• Moetsi: Avant (Ukraine), Skopinsky Pharmaceutical Plant, ALSI Pharma, ZiO-Zdorovye, Severnaya Zvezda, Ozon LLC, Biochemist, Obolenskoye - kgwebo ya meriana, Canonfarm Production CJSC, VERTEX (Russia)

Karolo e ka sehloohong ea lithethefatsi ke lisinopril dihydrate. Empa, ho latela moetsi oa moriana, sebopeho sa lintho tse ling se ka fapana.

Khamphani ea Seukraine Avant e hlahisa Lisinopril ka likarolo tse thusang joalo ka starch ea poone,calcium hydrogen phosphate,iron oxide, mannitol,magnesium stearate.

Mme moetsi oa Marussia ALSI Pharma o hlahisa sehlahisoa ka likarolo tse latelang tse latelang: setlolo sa pregelatinized,silicon dioxide e kolloidal,talcum phofo,lactose monohydrate, microcrystalline cellulose,magnesium stearate.

Ntle le moo, mekhoa e joalo ea ho lokolla lithethefatsi e tsejoa e le Lisinopril-Ratiopharm, Lisinopril-Astrafarm, Lisinopril Teva, Lisinopril Stada. Li na le likarolo tse latelang tse latelang:

• Lisinopril-Astrapharm - starch ea poone,silicon dioxide e kolloidal,mannitol,calcium hydrogen phosphate, magnesium stearate,
• Lisinopril-Ratiopharm - mannitol,calcium hydrogen phosphate, magnesium stearate, setlolo sa pregelatinized, sodium croscarmellose (Matlapa a 20 mg a na le dae PB-24824, le moriana matlapeng a 10 mg o na le dae PB-24823).

Lisinopril Stada e na le motsoako o sebetsang lisinopril hydrate. Ntle le moo, lintho tse latelang tse latelang: setlolo sa pregelatinized,silicon oxide colloidal anhydrous, mannitol,magnesium stearate,starch ea poone, calcium phosphate disubstituted dihydrate.

Pharmacodynamics le pharmacokinetics

Literata tsa Lisinopril block ACEeketsa dikahare endo native vasodilating GHG le ho thibela phetoho angiotensin I ka angiotensin II. Ba boetse ba fokotsa ho sokoloha. arginine-vasopressinle endothelin-1, fokotsa myocardial afterload, khatello ea methapo ea pelo, khatello ea mali le methapo ea methapo ea mali. Ho bakuli ba nang le ho nyekeloa ke pelo eketsa mamello ea myocardial ho ikoetlisa le tlhahiso ea pelo. Tlatsetsa mosebetsing o eketsehileng renin plasma.

Mori o thibela lithane renin-angiotensin tsamaiso ea pelo, e thibela ponahalo ea hypertrophy ea myocardial le litheolelo li-ventricle tsa leqhetsoana kapa li thusa ho nyamela hoa bona.

Matla a sethethefatsi a hlaha kamora metsotso e ka bang 60, a eketseha bakeng sa lihora tse 6-7 mme a tšoarella ka letsatsi. Boholo antihypertensivephello e iponahatsa ka nako ea libeke tse 'maloa.

Ntho e sebetsang e ananeloa ke hoo e ka bang 25%. Nako ea lijo ha e ame ho amoha bana. Puisano le liprotheine tsa plasma li tlase. Ntho e sebetsang ha e khetholloe 'me ea bululeloa ke liphio ha li sa fetoloe. Ho felisoa ha halofo ea bophelo ke lihora tse 12.

Contraindication

Moriana ha oa lokela ho nooa hypersensitivity ho likarolo tsa eona, lebone le ea boimana.

Ha ho tšoanelehe ho fana ka pheko ena bakeng sa:

• hyperkalemia,
• anaphylactoid reaction,
• collagenoses,
• cerebrovascular insuffidence,
• mosebetsi o sa sebetseng oa liphio le sebete,
• ka bobeli renal artery stenosis,
• a liphoofotsoana tse ling
• gout,
• botsofe
• Edema ea Quincke ka nalane,
• khatello ea mokokotlo,
• hypotension,
• liphetoho tse thibelang hore li se ke tsa tsoa madi ho tsoa pelong
• hyponatremia, hammoho le ha u ja ka mokhoa o lekanyelitsoeng oa sodium,
• stenosis ea methapo e le 'ngoe ea methapo,
• hyperuricemia,
• lilemo tsa bana.

Litlamorao

Litla-morao li ka fapana, li hlaha litsing tse fapaneng le liketsong:

Ntle le moo, liponahatso tse latelang lia khoneha: nts'etsopele ea tšoaetso, ho theola boima ba 'mele, mofufutso, lefu la tsoekereho phahamisa antinuclear antibody titer le dikahare urea, goutkeketseho ea boemo moeinine, hyperkalemia, hyperuricemia, feberu, allergy, ho omella, hyponatremia.

Haeba ho na le litla-morao life tse fumanoeng, o lokela ho etela setsebi hang-hang.

Bongata

Haeba ho na le overdose, hangata ho hlaha acute ea methapo ea kutlo. E le kalafo, letsoai la 'mele lea tsamaisoa. Phekolo ea matšoao e etsoa.

Ntle le moo, tšabo e ka etsahala, Hyperventilation, ho hloleha ha renal renal, bradycardia, ho khohlela, ho leka-lekana li-electrolyte mading tachycardiaho otla ha pelo ho tsekelaho ikutloa o tšoenyehile.

Setlhare se tlameha ho hlakoloa. Haeba mokuli a hlokometse, a hlatsoa mpa, a beha mokuli mokokotlong ka ho phomola hlooho, maoto le matsoho a hae a behelletsoe ka thoko. Ntle le moo, lia fana hangosorbents.

Ha u sebelisa meriana ka tekanyetso e phahameng haholo, mokuli o lokela ho kena sepetlele hanghang. Sepetlele, kalafo e etsoa ka sepheo sa ho boloka e tloaelehileng khatello ea litloloho potoloha ha mali, ho hema, ho khutlisetsa molumo oa mali le potoloha le tšebetso e tloaelehileng ea liphio. E sebetsa hemodialysis. Etsa bonnete ba hore u lekola matšoao a mesebetsi ea bohlokoa, hammoho le boemo moeinine le li-electrolyteserumeng sa mali.

Tšebelisano

Ho nka lithethefatsi ka antihypertensivemeriana e ka u tsosetsa tlatsetso antihypertensive e sebetsang.

Li-diuretics tsa potasiamo-sparing, tse nkang letsoai le leng le nang le potasiamo, hammoho le lithethefatsi tse nang le potasiamo li eketsa monyetla oa nts'etsopele hyperkalemia.

Ho kopanya le li-blocker ACE le NSAIDse eketsa menyetla ea ts'ebetso ea ho fokola ha renal. Maemong a sa tloaelehang, ho ka etsahala hyperkalemia.

Le likopo ka kopanelo le loopback le thiazide diuretics e sithabetse ke ho holisoa antihypertensive ketso. Sena se boetse se eketsa kotsi ea ts'ebetso ea renal e holofetseng.

Indomethacin kapa lichelete ka estrogen hammoho le lisinopril li lebisa ho fokotseha antihypertensive liketso tsa morao-rao. Kamohelo e tšoanang Insulin lehypoglycemic lithethefatsi li ka baka hypoglycemia.

Motsoako le clozapine o lebisa ho keketseho ea litaba tsa oona ho plasma. Ha a ntse a nka lithium carbonate boemo ba bona ka hara serum ea mali boa eketseha. Sena se ka tsamaisana le matšoao a botaoa ba lithium.

Setlhare le sona se eketsa phello ea ethanol. Matšoao a botahoa a mpefala. Ka nako e ts'oanang, keketseho e khonahala antihypertensive litlamorao tsa lisinopril, ka hona hoa hlokahala ho qoba joala nakong ea kalafo ka sethethefatsi sena kapa ho se se nke ka mor'a lihora tse 24 ka mor'a ho noa joala.

Ts'ebeliso ea meriana ena hammoho le lichelete tsa anesthesianarcotic analgesics, antidepressant, mesifa ea ho phomola le hypotensive ketso, hammoho le lipilisi tsa ho robala li lebisa keketseho antihypertensive phello.

Supombolytics eketsa menyetla hypotension ea methapo. Motsoako ona o lokela ho laeloa ka hloko mme o shebe boemo ba mokuli ka hloko.

Sympathomimetics fokolisa haholo antihypertensive litlamorao tsa moriana. Motsoako le lithethefatsi tse fanang myelosuppressketso e eketsang kotsi agranulocytosis le / kapa neutropenia.

Tšebeliso e kopanetsoeng le Allopurinol, immunosuppressants, Procainamide, cytostatics, corticosteroids ho ka baka leukopenia.

Ho lets'olloLitlhare li ka etsahala anaphylactoid reaction molemong oa kopophallo e phahameng ea polyacrylonitrile tšepe sulfonate membranes.

Fomati ea ho lokolloa, sephutheloana le sebopeho Lizoril ®

Li-pcs tse 10 - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
14 li-PC. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.

Bahlomphehi: starch, mannitol, dicalcium phosphate dihydrate, magnesium stearate, dae oxide e khubelu.

Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
14 li-PC. - Mabokose (2) - lipakete tsa karete.

Bahlomphehi: starch, mannitol, dicalcium phosphate dihydrate, magnesium stearate, dae oxide e khubelu.

Li-pcs tse 10 - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
14 li-PC. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.

Bahlomphehi: starch, mannitol, dicalcium phosphate dihydrate, magnesium stearate, dae oxide e khubelu.

Li-pcs tse 10 - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
14 li-PC. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.

Ketso ea pharmacological

ACE inhibitor. E thibela ho thehoa ha angiotensin II ho tsoa ho angotensin I. E fokotsa litaba tsa angiotensin II 'me e lebisa ho fokotseha ka kotlolloho ha aldosterone. Fokotsa ho senyeha ha bradykinin mme ho eketsa motsoako oa prostaglandin. Fokotsa khatello ea methapo ea pelo, khatello ea mali, khatello ea methapo, khatello ea methapo, e baka keketseho ea phello ea pelo le ho mamella mamello ea khatello ea maikutlo ho bakuli ba nang le ho nyekeloa ke pelo. E eketsa methapo e mengata haholo ho feta methapo. Litlamorao tse ling li hlalosoa ke phello ea li-system tsa renin-angiotensin. Ka tšebeliso ea nako e telele, hypertrophy ea myocardium le marako a methapo ea methapo ea mofuta o pholohileng a fokotseha. E ntlafatsa phepelo ea mali ho ischemic myocardium. Li-inhibitors tsa ACE li lelefatsa nako ea bophelo ho bakuli ba nang le ho nyekeloa ke pelo le ho liehisa tsoelo-pele ea ho se sebetse hantle ha methapo ea pelo ho bakuli kamora lefu la pelo le sa bonahaleng ka lebaka la ho hloleha ha pelo.

Ho qala ketso ke kamora hora e le 'ngoe. Phello e phahameng e khethoa kamora lihora tse 6,7, nako - lihora tse 24. Ka khatello ea mali ea methapo, phello e bonoa matsatsing a pele kamora ho qala kalafo, ho ba le phello e tsitsitseng kamora likhoeli tse 1-2

Mofumahali

Bolooa ba bioavailability ba lithethefatsi ke 25-50%, ka bofokoli ba protheine ea plasma. C max ho serum e fihlelloa kamora lihora tse 7. Ho ja ha ho ame ho monya.

Khatello ea tumello ka BBB le setlamorao sa placental li tlase.

Lysoril ha e tšeloe 'mele' me ha e phuthoe e sa fetoloe ka har'a moroto. Boholo ba eona bo lokolloa nakong ea karolo ea pele (ho sebetsa hantle T 1/2 - lihora tse 12), ebe ho lateloa ke karolo e hole (T 1/2 hoo e ka bang lihora tse 30)

Tekanyetso le tsamaiso

Ka hare. Ho khatello ea kelello ea methapo: Tekanyetso ea pele - 5 mg hang ka letsatsi, haeba ho hlokahala - ho fihlela 40 mg / ka letsatsi. Ho Ho nyekeloa ke pelo: Tekanyetso ea pele ke 2,5 mg, haeba ho hlokahala ho fihla ho 20 mg / ka letsatsi. Khahlano le nalane ea tlolo ea tekano ea motlakase oa motlakase, phekolo ea methapo ea methapo ea kutlo e sa sebetseng hantleng ka methapo ea methapo ea kutlo, "lethal" la pele ke 1.25 mg / letsatsi.

Polelo ea lihlopha tsa nosological

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Litaba tsa Tlhokahalo, ‰

Ngoliso Lizoril

• P N014842 / 01-2003

Webosaete ea semmuso ea k'hamphani RLS ®. Encyclopedia ea mantlha ea lithethefatsi le thepa ea bongaka ea semmuso ea Marang-rang ea Russia. Lenane la lithethefatsi Rlsnet.ru le fa basebelisi monyetla oa ho fumana litaelo, litheko le litlhaloso tsa lithethefatsi, tlatsetso ea lijo, lisebelisoa tsa bongaka, lisebelisoa tsa bongaka le lihlahisoa tse ling. Tataiso ea meriana e kenyelletsa tlhahisoleseling mabapi le sebopeho le mofuta oa tokollo, ts'ebetso ea meriana Sesebelisoa sa lithethefatsi se na le litheko tsa meriana le lihlahisoa tsa meriana ho la Moscow le metseng e meng ea Russia.

Ho thibetsoe ho fetisa, ho kopitsa, ho tsamaisa tlhahisoleseling ntle le tumello ea RLS-Patent LLC.
Ha u qotsa lisebelisoa tsa tlhahisoleseling tse phatlalalitsoeng maqepheng a sebaka sa marang-rang sa www.rlsnet.ru, ho hokela mohloli oa tlhahisoleseling.

Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

Matšoao a ho sebelisoa

Arterial hypertension (ho kenyelletsa le letšoao), CHF, kalafo ea pele ea infarction ea myocardial e mpe ho bakuli ba tsitsitseng ba hemodynamically (e le karolo ea kalafo e kopaneng).

E le karolo ea kalafo e kopaneng bakeng sa infarction e mpe ea myocardial (ka lihora tse 24 tsa pele, e nang le hemodynamics e tsitsitseng).

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka hare, ka khatello ea mali ea methapo - 5 mg hang ka letsatsi. Ha ho se na phello, lethal dose le eketseha ka matsatsi a mang le a mang a mabeli ka makhetlo a mabeli ho isa ho 5 mg ho ea karolelano ea kalafo ea 20-25 mg / ka letsatsi (ho eketsa tekanyetso ka holimo ho 20 mg / letsatsi hangata ha ho lebise ho fokotseheng ho eketsehileng ha khatello ea mali). Tekanyo e phahameng ea letsatsi le letsatsi ke 80 mg.

Ka HF - qala ka 2,5 mg hang, e lateloe ke keketseho ea tekanyetso ea 2,5 mg mg ka mora matsatsi a 3-5.

Ho batho ba tsofetseng, phello e boletsoeng ka nako e telele e atisang ho sebelisoa hangata e bonoa, e amanang le ho fokotseha ha sekhahla sa tlhahiso ea lisinopril (ho khothalletsoa ho qala kalafo ka 2,5 mg / ka letsatsi).

Ho sa sebetseng hantle ha renal, cumulation e etsahala ka fokotseho ea filtara e ka tlase ho 50 ml / min (lethal dose le lokela ho fokotsoa ka makhetlo a 2, CC e le tlase ho 10 ml / min, tekanyetso e tlameha ho fokotsoa ka 75%).

Ka khatello ea methapo ea methapo ea methapo e sa feleng, kalafo ea tlhokomelo ea nako e telele e bonts'oa ho 10-15 mg / letsatsi, ka ho nyekeloa ke pelo - ho 7.5-10 mg / ka letsatsi.

Litaelo tse khethehileng

Tlhokomelo e khethehileng ea hlokahala ha ho laeloa bakuli ba nang le methapo ea methapo ea methapo ea methapo kapa stenosis ea methapo e le 'ngoe ea methapo (mohlomong keketseho ea khatello ea urea le creatinine maling), bakuli ba nang le lefu la methapo ea methapo kapa lefu la mokokotlo, le pelo e senyehileng (pelo e ka fokotsoang, myocardial infarction, stroke). Ho bakuli ba nang le ho nyekeloa ke pelo, hypotension ea methapo ea kutlo e ka lebisa ho se sebetse hantle ha renal.

Ha u sebelisa lithethefatsi tse fokotsang khatello ea mali ho bakuli ba nang le ts'ebetso e ngata ea ho buoa kapa nakong ea ho opa hlooho, lisinopril e ka thibela ho etsoa ha angiotensin II, maemong a mahareng le ho patalla renin secretion.

Tšireletseho le katleho ea lisinopril ho bana ha li e-so thehiloe.

Pele o qala kalafo, ho a hlokahala ho buseletsa tahlehelo ea metsi le matsoai.

Ts'ebeliso nakong ea bokhachane e hanyetsitsoe ntle le haeba ho ka se khonehe ho sebelisa lithethefatsi tse ling kapa li sa sebetse (mokuli o lokela ho tsebisoa ka kotsi e ka bang teng ho lesea).

Lipotso, likarabo, litlhahlobo mabapi le lithethefatsi Lizoril

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebeletsang e le sebaka sa boipiletso ba motho ho setsebi.

Litla-morao

Ho tsoa ho tsamaiso ea methapo ea pelo: ho fokotseha ha khatello ea mali, bohloko ba sefuba, ka seoelo - orthostatic hypotension, tachycardia, bradycardia, ponahalo ea matšoao a ho hloleha ha pelo, mokokotlo oa atrioventricular conduction.

Ho tloha tsamaisong ea methapo: ho tsekela, ho opeloa ke hlooho, ho tepella, ho otsela, ho tsikinyeha ha mesifa ea maoto le melomo, seoelo - lefu la asthenic, khatello ea maikutlo le pherekano.

Ho tsoa pampiring ea ka mpeng: ho nyekeloa ke pelo, dyspepsia, anorexia, phetoho ea tatso, bohloko ba ka mpeng, lets'ollo, molomo o omileng.

Litho tsa Hematopoietic: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia (e fokotsehile hemoglobin, erythrocytopenia).

Ho tsoa ts'ebetsong ea ho hema: dyspnea, bronchospasm, apnea.

Litla-morao: Alonegicotic edema, lekhopho la letlalo, ho hlohlona.

Matšoao a laboratori: hyperkalemia, hyperuricemia, ka seoelo - ketsahalo e eketsehang ea "hepatic" transaminases, hyperbilibinemia.

Tse ling, ho khohlela ho omelletseng, potency e fokotsehile, ka seoelo - ho hloleha ha real haholo, arthralgia, myalgia, feberu, edema (leleme, molomo, maoto le matsoho), nts'etsopele ea liphio tsa fetus.

Likarolo tsa ts'ebeliso

Tlhokomelo e khethehileng ea hlokahala ha ho laeloa bakuli ba nang le methapo ea methapo ea methapo ea methapo kapa stenosis ea methapo e le 'ngoe ea methapo (mohlomong keketseho ea khatello ea urea le creatinine maling), bakuli ba nang le lefu la methapo ea methapo kapa lefu la mokokotlo, le pelo e senyehileng (pelo e ka fokotsoang, myocardial infarction, stroke). Ho bakuli ba nang le ho nyekeloa ke pelo, hypotension ea methapo ea kutlo e ka lebisa ho se sebetse hantle ha renal.

Ho fokotseha ha khatello ea mali nakong ea kalafo hangata ho hlaha le ho fokotseha hoa BCC ho bakoang ke kalafo ea diuretic, thibelo ea ho ja letsoai, ho hlohlona, ​​lets'ollo, kapa ho hlatsa.

Phekolo ea lisinopril ka infarction e mpe ea myocardial e etsoa khahlano le semelo sa kalafo e tloaelehileng (thrombolytics, ASA, beta-blockers). E tsamaisana le iv tsamaiso ea nitroglycerin kapa TTC nitroglycerin.

Ha u sebelisa lithethefatsi tse fokotsang khatello ea mali ho bakuli ba nang le ts'ebetso e ngata ea ho buoa kapa nakong ea ho opa hlooho, lisinopril e ka thibela ho etsoa ha angiotensin II, maemong a mahareng le ho patalla renin secretion. Pele ho buuoa (ho kenyeletsoa le ho buoa meno), ngaka e buoang / e robatsang mahlo e lokela ho tsebisoa ka ts'ebeliso ea inhibitor ea ACE.

Ho latela liphetho tsa lithuto tsa mafu a tšoaetso, ho nahanoa hore tšebeliso ea nako e le 'ngoe ea li-inhibitors tsa ACE le insulin, hammoho le lithethefatsi tsa molomo tsa hypoglycemic, li ka lebisa nts'etsopele ea hypoglycemia. Kotsi e kholo ea kholo ea kholo e bonoa nakong ea libeke tsa pele tsa phekolo e kopaneng, le ho bakuli ba nang le ts'ebetso ea renal e holofetseng. Bakuli ba nang le lefu la tsoekere ba hloka ho hlahlojoa ka hloko glycemia, haholo-holo khoeling ea pele ea kalafo e nang le ACE inhibitor.

Pele o qala kalafo, ho a hlokahala ho buseletsa tahlehelo ea metsi le matsoai.

Lisosa tsa kotsi bakeng sa nts'etsopele ea hyperkalemia li kenyelletsa ho se sebetse hantle ha renal, lefu la tsoekere le tšebeliso e le 'ngoe ea potasiamo (spironolactone, triamteren kapa amiloride), litokisetso tsa K + kapa tse nkang letsoai tse nang le K +. Ho hloekisoa nako le nako ha khatello ea K + maling a mali e khothalletsoa.

Ho bakuli ba nkang li-inhibitors tsa ACE nakong ea takatso ea moriana, ho ka seoelo ho ka bang le karabelo e behang bophelo ba anaphylactoid. Hoa hlokahala ho tlohela phekolo ka nakoana le ACE inhibitor pele u qala boikoetliso.

Liphetoho tsa anaphylactoid li ka hlaha ha hemodialysis e etsoa ho sebelisoa li-membrane tse nang le phallo e phahameng (ho kenyeletsoa le AN 69). Hoa hlokahala ho nahana ka monyetla oa ho sebelisa mofuta o mong oa membrane bakeng sa dialysis kapa litlhare tse ling tsa antihypertensive.

Tšireletseho le katleho ea lisinopril ho bana ha li e-so thehiloe.