Mokhoa oa ho sebelisa lithethefatsi Augmentin SR?

Ts'oaetso ea baktheria e bakoang ke likokoana-hloko tse tebileng: tšoaetso e tlase ea phefumoloho (bronchitis, pneumonia, empuralma, lesapo la matšoafo), ts'oaetso ea litho tsa ENT (sinusitis, tonsillitis, otitis media), ts'oaetso ea tsamaiso ea genitourinary le litho tsa pelvic (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, ho ntša mpa ka septic, sepsis ea morao-rao, pelvioperitonitis, chancre e bonolo, gonorrhea), ts'oaetso ea letlalo le lisele tse bonolo (erysipelas, impetigo, sekondari. empa dermatoses nang le tšoaetso, abscesses, cellulitis, leqeba tshwaetso), osteomyelitis, tšoaetso postoperative, thibelo ea tsoaetso eo ka ho buoa.

Foromo ea litekanyetso

matlapa a lokisitsoeng a filimi a koahetsoeng ka mokhoa o hlophisitsoeng, lyophilisate bakeng sa ho hlophisoa ha tharollo bakeng sa tsamaiso ea methapo, phofo bakeng sa ho hlophisoa ha ho emisoa bakeng sa tsamaiso ea molomo, matlapa, phofo bakeng sa ho hlophisoa ha tharollo bakeng sa tsamaiso ea methapo, matlapa a hasaneng

Contraindication

Hypersensitivity ho likarolo tsa Augmentin CP (ho kenyelletsa le cephalosporin le tse ling tse thibelang likokoana-hloko tsa beta-lactam), mononucleosis e tšoaetsanoang (ho kenyelletsa le ponahalo ea lekhopho le joalo ka sesepa), phenylketonuria, liketsahalo tsa sesole sa jaundice kapa lesapo le senyehileng ka lebaka la ts'ebeliso ea amoxicillin / clavulanova nalane ea acid, CC e ka tlase ho 30 ml / min (bakeng sa matlapa a 875 mg / 125 mg).

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Melemo ea Augmentin SR e fanoa ho latela amoxicillin. Mokhoa oa ho fokotsa litekanyetso o beoa ka bonngoe ho latela botebo ba thupelo le sebaka sa ts'oaetso, kutloisiso ea pathogen.

Bana ba ka tlase ho lilemo tse 12 - ka tsela ea litokisetso tse ling tsa LF tse nang le lintho tse tšoanang tse sebetsang: ho emisoa, sirapo kapa marotholi bakeng sa tsamaiso ea molomo. Tekanyetso e le 'ngoe e behiloe ho latela lilemo: bana ho isa ho likhoeli tse 3 - 30 mg / kg / letsatsi ho litekanyetso tse 2 tse arohaneng, likhoeli tse 3 le ho feta - bakeng sa tšoaetso ea tebang ea boima - 25 mg / kg / letsatsi ho litekanyetso tse 2 tse arohaneng kapa 20 mg / kg / letsatsi ho litekanyetso tse 3, ka ts'oaetso e matla - 45 mg / kg / letsatsi ho litekanyetso tse 2 kapa 40 mg / kg / letsatsi ho litekanyetso tse 3.

Batho ba baholo le bana ba kaholimo ho lilemo tse 12 kapa boima ba 40 kg kapa ho feta: 500 mg makhetlo a 2 / letsatsi kapa 250 mg makhetlo a 3 / ka letsatsi. Ho tsoaetso e matla le tšoaetso ea pampitšana ea phefumoloho - 875 mg makhetlo a 2 / ka letsatsi kapa 500 mg makhetlo a 3 / ka letsatsi.

Tekanyo e phahameng ea letsatsi le letsatsi ea amoxicillin ho batho ba baholo le bana ba kaholimo ho lilemo tse 12 ke 6 g, bakeng sa bana ba ka tlase ho lilemo tse 12 - 45 mg / kg boima ba mmele.

Tekanyo e phahameng ea letsatsi le letsatsi ea clavulanic acid ho batho ba baholo le bana ba ka holimo ho lilemo tse 12 ke 600 mg, bakeng sa bana ba ka tlase ho lilemo tse 12 - 10 mg / kg boima ba mmele.

Ka bothata ba ho koenya ho batho ba baholo, ho khothalletsoa ts'ebeliso ea emisoa.

Maemong a ho hloleha ho phekola a renal ho sa sebetseng, ho fanoa ka tekanyo le maqhubu a tsamaiso (tsamaiso ea litokisetso tsa LF tse nang le lintho tse tšoanang tse tsoang ho baetsi ba bang) ho latela QC: ha QC e feta 30 ml / min, tokiso ea tekanyetso ha e hlokehe, ka QC 10-30 ml / min: ka hare - 250- 500 mg / letsatsi le leng le le leng lihora tse 12, le CC ka tlase ho 10 ml / min - 1 g, ebe 500 mg / letsatsi iv kapa 250-500 mg / letsatsi ka molomo ka nako e le ngoe. Bakeng sa bana, tekanyetso e lokela ho fokotsoa ka tsela e ts'oanang.

Bakuli ba nang le hemodialysis - 250 mg kapa 500 mg ea Augmentin CP ka molomo ka tekanyetso e le 'ngoe, tekanyetso e le' ngoe ea 1 nakong ea dialysis le lethal dose le le leng qetellong ea thuto.

Ketso ea pharmacological

Litokisetso tse kopaneng tsa amoxicillin le clavulanic acid, inhibitor ea beta-lactamase. E etsa bactericidal, e thibela ho hlophisoa ha lerako la baktheria.

E sebetsa khahlanong le libaktheria tse ntle tsa aerobic gram (ho kenyeletsa le beta-lactamase e hlahisang mefuta e meng): Staphylococcus aureus,

Baktheria ea aerobic gram-negative: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis.

Likokoana-hloko tse latelang li ka tšoaetsoa ke Augmentin CP feela ho vitro: Staphylococcus epidermidis, Streptococcus pyogene, Streptococcus anthracis, Streptococcus pneumoniae, virreans tsa Streptococcus, Enterococcus faecalis, Coryneococcocococeptept.

"Aerobic gram-negative bacteria" (ho kenyeletsa le lithane tse hlahisang beta-lactamase): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp. ), Campylobacter jejuni,

Libaktheria tsa anaerobic gram-negative (ho kenyelletsa le mefuta e hlahisang beta-lactamases): Bacteroides spp, ho kenyeletsa le Bacteroides fragilis.

Clavulanic acid e Augmentin CP inhibits mofuta oa II, III, IV le V mefuta ea beta-lactamases, e sa sebetseng khahlanong le mofuta I beta-lactamases, e hlahisoang ke Pseudomonas aeruginosa, Serratia spp, Acinetobacter spp. Clavulanic acid e na le tropism e phahameng bakeng sa penicillinase, ka lebaka leo e theha motsoako o tsitsitseng ka enzyme, e thibelang ho senyeha ha enzymatic ea amoxicillin tlasa ts'usumetso ea beta-lactamases.

Litlamorao

Ho tsoa ho ts'ilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, gastritis, stomatitis, glossitis, ts'ebetso e eketsehang ea lipilisi tsa "sebete", maemong a sa tloaelehang - cholestatic jaundice, hepatitis, ho hloleha ha sebete (hangata ho batho ba baholo, banna, ka kalafo ea nako e telele), pseudomembranous le hemorrhagic colitis (e ka boela ea e-ba teng ka mor'a phekolo), enterocolitis, leleme le letšo "le lesoeu", le fifatsa enamel ea meno.

Litho tsa Hematopoietic: Keketseho e feto-fetohang ea nako ea prothrombin le nako ea ho tsoa mali, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

Ho tsoa ts'ebetsong ea methapo: ho tsekela, ho opeloa ke hlooho, khatello ea maikutlo, ho tšoenyeha, phetoho ea boitšoaro, letsoalo.

Boitšoaro ba lehae: maemong a mang, phlebitis setsing sa ente ea iv.

Liphetoho tse ka bakoang ke likarolo tsa Augmentin SR: uritisaria, erythematous rashes, ka seoelo - makhopho a mangata a makatsang, ho se tsitsinyehe, anioylema, seoelo ka seoelo - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), alculgic vasculitis, serum vasculitis a hlobaetsang le pustulosis e matla e akaretsang.

Tse ling: candidiasis, nts'etsopele ea bonohe ba linaleli, nephritis ea li-interstitial, crystalluria, hematuria.

Litaelo tse khethehileng

Ka kalafo ea thupelo le Augmentin SR, hoa hlokahala ho lekola boemo ba ts'ebetso ea mali, sebete le liphio.

Bakeng sa ho fokotsa kotsi ea litlamorao ho tsoa mpeng ea mala, moriana o lokela ho nooa le lijo.

Hoa khoneha ho hlaolela superinitness ka lebaka la kholo ea microflora ha e na taba le eona, e hlokang phetoho e lekanang ea kalafo ea lithibela-mafu.

E kanna ea hlahisa litholoana tse ntle tsa 'nete boikemisetsong ba tsoekere moseneng. Maemong ana, ho khothalletsoa ho sebelisa mokhoa oa glucose oxidant bakeng sa ho khetholla mokokotlo oa glucose ka har'a moroto.

Kamora ho hlapisoa, ho emisoa ha hoa lokela ho bolokoa matsatsi a sa feteng a 7 sehatsetsing, empa se sa hoama.

Ho bakuli ba nang le hypersensitivity ho penicillin, ho ka ba le lintho tse ling tse ka u sitisang ho etsa lintho ka litlhare tse thibelang likokoana-hloko tsa cephalosporin.

Ho ile ha senoloa maemo a ntlafatso ea colitis ea bokhachane ho masea a sa tsoa hlaha le ho basali baimana ba ileng ba phatloha ka pelehi ka litho.

Tšebelisano

Li-antacids, glucosamine, laxatives, aminoglycosides li fokotseha butle hape li fokotsa ho monya likarolo tsa Augmentin CP, asiti ea ascorbic e eketsa ho monya.

Lithethefatsi tsa bacteriostatic (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) li na le tšusumetso.

E eketsa ts'ebetso ea li-anticoagulants tse sa tobang (ho hatella microflora ea mala, ho fokotsa ho hlophisoa ha vithamine K le index ea prothrombin). Ka tsamaiso e le 'ngoe ea li-anticoagulants, ho hlokahala hore ho hlahlojoe matšoao a ho senyeha ha mali.

Fokotsa katleho ea lithibela-pelehi tsa molomo, lithethefatsi, nakong ea metabolism eo PABA e thehiloeng ho eona, ethinyl estradiol - kotsi ea ho tsoa mali "ho phatloha".

Diuretics, allopurinol, phenylbutazone, NSAIDs le lithethefatsi tse ling tse thibelang secretion ea tubular li phahamisa mokokotlo oa amoxicillin ka sebopeho sa Augmentin SR (clavulanic acid e hlahisoa haholo ke moferefere oa glomerular).

Allopurinol e eketsa kotsi ea ho ba le lekhopho la letlalo.

Lipotso, likarabo, litlhahlobo mabapi le lithethefatsi Augmentin SR

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebeletsang e le sebaka sa boipiletso ba motho ho setsebi.

Fomu ea tokollo

Augmentin e fumaneha matlapeng a koahetsoeng ka filimi, liphofo tsa tharollo ea ente, le ntho e omeletseng bakeng sa marotholi a hlapollang. Li-pie bakeng sa ho hlophisa ho emisoa ha Augmentin le sirapo le tsona lia hlahisoa. Likhoele tsa lithethefatsi tse nang le lintho tse tšoanang tse sebetsang ke tsena: Amoxiclav, Bactoclav, Arlet, Klamosar.

Tekanyetso le tsamaiso

Ho latela litaelo tseo Augmentin a khothalletsoang hore li nooe qalong ea lijo, tekanyetso ea moriana e fanoa ka bomong ho latela lilemo tsa mokuli le ho teba ha tšoaetso. Ka kalafo, hoa khoneha ho etsa kalafo ea mehato - pele, ho sebelisoa taolo ea methapo ea moriana ebe ba fetohela ho tsamaiso ea molomo. Nako ea kalafo le Augmentin hangata ha e fete matsatsi a 14 ntle le ho ntlafatsa setšoantšo sa tleliniki. Bakeng sa batho ba baholo le bana ba kaholimo ho lilemo tse 12, ho laetsoe tšoaetso e bonolo le e leka-lekaneng ea 1 Letlapa la 0,375 g makhetlo a 3 ka letsatsi, bakeng sa bokuli bo matla 1 Letlapa la 0,625 g kapa matlapa a 2,375 g makhetlo a 3 ka letsatsi. Ka tsamaiso ea methapo, e lumelloa ho sebelisa lithethefatsi ka mor'a lihora tse ling le tse ling tse 6 ka tekanyo e phahameng ea letsatsi le letsatsi ea 7.2 g. Bakuli ba nang le ts'ebetso ea mokokotlo oa mokokotlo nakong ea kalafo ba hloka ho lokisoa ha tekanyetso ea meriana.

Augmentin bakeng sa bana ba ka tlase ho selemo sa 1 hangata e beoa ka mokhoa oa marotholi. Litaelo li bonts'a hore ha a le lilemo li ho isa ho likhoeli tse 3, tekanyetso e le 'ngoe ke 0,75 ml, ho tloha ho likhoeli tse 3 ho isa ho 12 - 1,25 ml. Ha ts'oaetso ea ts'oaetso e matla ea ts'ebetso ea methapo e kenella ka mor'a lihora tse ling le tse ling tse 6, tekanyetso e le 'ngoe ea Augmentin ho bana ho tloha ho likhoeli tse 3 ho isa ho tse 12 ke boima ba' mele ba 30 mg / kg, ho isa ho likhoeli tse 3 ka tekanyetso e le ngoe ka lihora tse 12. Hape, bana ba ka tlase ho lilemo tse 12 ba khethoa hore ba emisoe ke Augmentin kapa sirapo. Ho ea ka litaelo, bana ho tloha likhoeli tse 9 ho isa ho lilemo tse 2 ba beiloe 2,5m (0,156 g / 5 ml), ho tloha ho lilemo tse 2 ho isa ho tse 7 - 5 ml (0.156 g / 5 ml), ho tloha ho lilemo tse 7 ho isa ho 12 - 10 ml (0.156 g / 5 ml) makhetlo a mararo ka letsatsi, ka bokuli bo matla, lethal dose e lumelloa habeli.

Ho emisoa ha Augmentin ho lokiselitsoe ho sebelisoa hang-hang pele ho tšebeliso, phofo e qhibiliha ka metsing a phehiloeng ka mocheso oa kamore. Metsi a kenyelletsoa letšoao le tšoailoeng vide, ha lintho tse ka hare li tsukutloa butle-butle, ebe li lula ho fihlela li qhibilihile ka nako e ka bang metsotso e 5. Pele ho ts'ebeliso e 'ngoe le e' ngoe, vial e lokela ho ts'oaroa ka matla, ho bona hore na tekanyetso ke efe, sekepe se lekanyang se sebelisoa, se tšeloa ka hloko ka metsi ka mor'a tšebeliso e ngoe le e ngoe. Ho emisoa ho kentsoeng ho bolokiloe sehatsetsing nako e sa feteng matsatsi a 7, empa ha e kenelle.

Melemo ea pharmacological

Farmakokinetics

Ka bobeli likarolo tsa Augmentin® SR (amoxicillin le clavulanic acid) li qhibilihile ka ho felletseng ka litharollo tse metsi litekanyetsong tsa pH tsa mmele. Likarolo tsena ka bobeli li kenella ka potlako 'me li tsamaisoa hantle ke tsamaiso ea molomo. Tlhahiso ea Augmentin® SR e ntlafala ha e nooa qalong ea lijo.

Lithethefatsi

Dose(mg)

T> MIC^ h(%)

Cmax (mg/l)

Tmax (h)

Auc

T1 / 2 (h)

Amoxicillin

Augmentin SR 1000 / 62.5 mg x 2

Se-clavulanate

Augmentin SR 1000 / 62.5 mg x 2

ND - ha e hlalosoe

T> Nako ea MIC> mahlaseli a fokolang a thibelo

Litafole tsa tokollo tsa Augmentin® Li-SR li na le profilacokinetic / pharmacodynamic e ikhethang.

Letšoao T> MIC e fumanoe ha ho fanoa ka lengolo la lithethefatsi Augmentin® SR e fapane haholo le e fumanoeng le litekanyetso tse tšoanang tsa matlapa a nang le ho lokolloa hang-hang ha lintho tse sebetsang.

Ha e fanoa ka molomo, litekanyetso tsa kalafo tsa amoxicillin le clavulanic acid li bonoa ka har'a lithane le mokelikeli oa lipakeng. Litlhahlobo tsa kalafo tsa lintho tsena ka bobeli li fumanoa ka har'a lesapo la nyooko, lisele tsa ka mpeng, letlalo, li-adipose le mesifa ea mokokotlo, hammoho le mokelikeli oa mokokotlo le oa pherese. Amoxicillin le clavulanic acid e tlama liprotheine ka mokhoa o fokolang, liphuputso li fumane hore litheko tse kopanyang liprotheine ke 25% bakeng sa clavulanic acid le 18% bakeng sa amoxicillin ea likelello tsa bona tsa plasma kaofela. Boithutong ba liphoofolo, ha ho qopitso ea likarolo tsena tsa setho leha e le sefe se seng se thehiloe.

Amoxicillin, joalo ka penicillin e ngoe e ka fumanoa lebese la matsoele. Letšoao la clavulanic acid le lona le ka fumanoa lebeseng. Boithuto ba ho ikatisa ba liphoofolo bo bontšitse hore amoxicillin le clavulanic acid li ka tšela sethaleng sa placental, empa ha ho na bopaki bo fumanoeng mabapi le ts'ebetso ea kemolo e sa senyeheng kapa litlamorao tse mpe ho lesea.

Amoxicillin e qepha ka mokhoa o itseng ka har'a moroto ka mokhoa o sa sebetseng oa penicillinic acid ka tekanyo e lekanang le 10-25% ea tekanyetso e nkuoeng. Clavulanic acid e tšelisitsoe 'meleng oa motho ho isa ho 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid le 1-amino-4-hydroxy-butan-2-e' ngoe mme e khaotsoe ka eona. moroto le mantle, hammoho le sebopeho sa khabone e nang le moea o tsoang.

Amoxicillin e hloekisoa haholo ke liphio, ha asiti ea clavulanic e hlohlorisoa ke methapo ea kutlo le e feteletseng. Hoo e ka bang 60-70% ea amoxicillin le 40-65% ea clavulanic acid li hlahisitsoe li sa fetoloe ka har'a moroto. Ts'ebeliso e kopaneng le probenecid e thibela tlhahiso ea amoxicillin, empa ha e liehe ho pepesetsoa ha lipono tsa clavulanate ke liphio.

Phetoho ea mori ha e hlokehe.

Bakuli ba nang le ts'oaetso ea renal

Ha ho na lebaka la ho fetola tekanyetso ea lithethefatsi ka lengolo la clearinine clearance> 30 di ml / min. Bakeng sa bakuli ba tumello ea creatinine e ka tlase ho 30 ml / min, ho sebelisa joala ha ho kgothaletsoe.

Bakuli ba Hemodialysis

Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng

Sebelisa ka hlokolosi; datha ea likhothaletso tsa dosing ha e ea lekana.

Pharadodynamics

Augmentin® SR ke motsoako o thibelang likokoana-hloko o nang le amoxicillin le clavulanic acid, e nang le bongata ba ketso ea bactericidal, e hananang le beta-lactamase.

Amoxicillin ke motsoako o mongata oa tlhaho o pharalletseng o sebetsang khahlanong le likokoana-hloko tse ngata tse seng ntle tsa grame le gram-negative. Amoxicillin e senngoa ke beta-lactamase mme ha e ame likokoana-hloko tse hlahisang enzyme ena.

Clavulanic acid ke beta-lactamate, e tšoanang ka sebopeho sa lik'hemik'hale ho penicillin, e nang le bokhoni ba ho kenya li-enzyme tsa beta-lactamase tsa likokoana-hloko tse hananang le penicillin le cephalosporins, ka tsela eo li thibela ho kenella ha amoxicillin. Haholo-holo, e na le ts'ebetso e phahameng khahlanong le plasmid beta-lactamases, eo ho eona ho hanyetsa lithethefatsi ho amanang khafetsa, empa e sa sebetseng hantle khahlano le mofuta oa 1 chromosomal beta-lactamases.

Ho ba teng ha clavulanic acid ho Augmentin® SR ho sireletsa amoxicillin ho litlamorao tse mpe tsa beta-lactamases mme e atolosa pono ea eona ea ts'ebetso ea antibacterial ka ho kenyelletsoa ha likokoana-hloko tseo hangata li hananang le penicillin le li-cephalosporins tse ling. Clavulanic acid ka sebopeho sa moriana o le mong ha e na litlamorao tsa bohlokoa tsa antibacterial.

Sistimi ea ho hanyetsa bothata

Clavulanic acid e sireletsa khahlanong le kholo ea ho hanyetsa e bakoang ke li-enzyme tsa beta-lactamase. Sebopeho sa sethethefatsi ka tokollo ea butle-butle ea lintho tse sebetsang se eketsa ts'ebetso ea lithethefatsi khahlanong le likokoana-hloko ka ho hanyetsa ho bakoang ke protheine e tlamang penicillin.

Amoxicillin e baka ho hanyetsa ha lithibela-mafu tse ling tsa beta-lactam, li-inhibitors tsa beta-lacamase le cephalosporins.

Ho isa Augmentin®SrLikokoana-hloko tse latelang lia utloahala:

Lifofane tse khothatsang: Bacillius anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroids, Streptococcuspneumoniae†,

Streptococcus pyogene*†, Streptococcus agalactiae*†, Viridans sehlopha sa streptococcus†, Streptococcus spp. (mefuta e meng ea β-hemolytic)*†, Staphylococcus aureus (e na le bothata ba methicillin) *, Staphylococcus saprophyticus (e na le bothata ba methicillin) Coagulase mpe staphylococcus (methicillin sensative)

Lirosa tse senang maikutlo: Bordetella pertussis,Haemophilus influenzae *,

Haemophilus parainfluenzae,Helicobacter pylori,Moraxella catarrhalis *,

Neisseria gonorrhoeae,Pasteurella multocida,Vibrio k'holera

Borreliaburgdorferi,Leptospiraictterohaemorrhagiae,Treponema pallidum

Li-anaerobes tse ntle le tse ntle: Clostridium spp.,Peptococcus niger,Pusostreptococcus magnus,Peptostreptococcus micros,Peptostreptococcusspp.

Li-anaerobes tsa Gram-negative: Bacteroides fragilis,Libaktheria spp., Kapnocytophaga spp., Eikenellali-corrodens,Fusobacteriumnucleatum,Fusobacterium spp., Porphyromonas spp., Prevotellaspp.

Likokoana-hloko tse nyenyane tse nang le bokhoni bo fumanehang bo fumanehang

Corynebacterium spp., Enterococcus faecium

Gram hampeaerobes:Escherichia coli *, Klebsiella oxytoca, Klebsiella pneumoniae *, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.

Likokoana-hloko tse nang le bothata ba tlhaho:

Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei,Legionella pneumophila,Morganella morganii,Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomas maltophilia,Yersinia enterolitica

Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

* Ho sebetsa hantle ho bonahetse litekong tsa bongaka.

Micro Likokoana-hloko tse seng beta-lactamase tse hlahisang

Tekanyetso le tsamaiso

Augmentin® SR e lokela ho sebelisoa ho latela tataiso ea molao ea lehae bakeng sa tšebeliso ea meriana ea lithibela-mafu, hammoho le tlhaiso-leseling ea lehae mabapi le monyetla oa ts'ebeliso ea lithethefatsi.

Augmentin® SR e etselitsoe phekolo ea nako e khuts'oane ea ts'oaetso ea baktheria e bakoang ke likokoana-hloko tse amehang ka moriana.

Susceptibility ho Augmentin® SR e fapana ka sebaka le nako. Hoa hlokahala ho ithuta lintlha tsa lehae ka ho ts'oaroa ha lithethefatsi, hape, haeba ho khoneha, ho nka boitsebiso le ho etsa tlhahlobo ea bona ea kutloisiso.

Bakeng sa ho ntlafatsa ho amoheloa ha Augmentin® SR e khothalletsoa hore e nooe qalong ea lijo. Phekolo ha ea lokela ho tsoelapele matsatsi a fetang 14 ntle le ho lekola boemo ba mokuli.

Lipilisi tsa Augmentin® Li-SR li na le mohala o arolang, o li lumellang hore li robehe halofo bakeng sa ho koenya, empa eseng ho fokotsa tekanyetso: halves ka bobeli e lokela ho nkuoa ka nako e le ngoe.

Motsoako o khothalelitsoeng ke matlapa a mabeli habeli ka letsatsi.

Batho ba baholo le ba lilemong tsa bocha (ba lilemo tse 16 le ho feta))

Matlapa a mabeli habeli ka letsatsi matsatsi a 7 ho isa ho a leshome

Ho eketseha ha bronchitis e sa foleng

Matlapa a mabeli habeli ka letsatsi matsatsi a 7

Sinus ea baktheria e matla

Matlapa a mabeli habeli ka letsatsi matsatsi a 10

Thibelo ea mathata a tšoaetsanoang a tikolohong ea bongaka ba meno

Matlapa a mabeli habeli ka letsatsi ka matsatsi a 5, ho qala ho nka e lokela ho ba nakong ea lihora tse 3 kamora ho buuoa

Foromo ena ea litekanyetso ha e reretsoe bana ba ka tlase ho lilemo tse 16.

Fokotsa Augmentin Dose® SR ha e hlokehe, litekanyetso li tšoana hantle le ho batho ba baholo.

Bakuli ba nang le ts'oaetso ea renal

Ha ho na lebaka la ho fetola tekanyetso ea lithethefatsi ka lengolo la clearinine clearance> 30 di ml / min. Bakeng sa bakuli ba tumello ea creatinine e ka tlase ho 30 ml / min, ho sebelisa joala ha ho kgothaletsoe.

Bakuli ba Hemodialysis

Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng

Ho sebelisa ka hloko, ho hlokahala ho hlokomela ts'ebetso ea hepatic nako le nako. Ha ho na data e lekaneng ho khothaletsa dosing.

Bongata

Matšoao gastrointestinal upsets le likhathatso tsa tekano ea metsi-electrolyte lia khonahala. Amoxicillin crystalluria e hlalosoa, maemong a mang e lebisang ho nts'etsopele ea ho se sebetse hantle ha methapo.

Phekolo: matšoao a kalafo, matšoao a khalemelo ea metsi-electrolyte. Augmentin® SR e tlosoa maling ka hemodialysis.

Setifikeiti sa ho ingolisa

Laboratoire GlaxoSmithKline, France

(100, tsela de Versailles, 78163 Marly-Le-Roi, Cedex)

Aterese ea mokhatlo e amohelang likopo ho tsoa ho bareki ka boleng ba lihlahisoa (thepa) Rephaboliking ea Kazakhstan

GlaxoSmith Klein Export Ltd Ofisi ea Baemeli ho Kazakhstan 050059, Almaty, st. Furmanova, 273

Nomoro ea mohala: +7 727 258 28 92, +7 727 259 09 96

Litšoantšo tsa 3D

Pharadodynamics

Amoxicillin ke motsoako o mongata oa tlhaho o pharalletseng o nang le lintho tse khahlanong le likokoana-hloko tse ngata tse ntle tsa gram le gram-negative. Ka nako e ts'oanang, amoxicillin e kotsing ea ho felisoa ke beta-lactamases, ka hona bongata ba ts'ebetso ea amoxicillin ha bo fetele ho likokoana-hloko tse hlahisang enzyme ena.

Clavulanic acid, beta-lactamase inhibitor e amanang le penicillin, e khona ho inactivate ea mefuta e mengata ea beta-lactam e fumanoang penicillin le cephalosporin e loants'ang likokoana-hloko. Clavulanic acid e sebetsa hantle ka ho lekaneng khahlanong le plasmid beta-lactamases, eo hangata e ikarabellang bakeng sa ho hanyetsa baktheria, mme e sa sebetse hantle khahlano le chromosomal beta-lactamase ea mofuta oa 1, e sa thibeloang ke clavulanic acid.

Ho ba teng ha clavulanic acid ho hlophisoa ha Augmentin ® ho sireletsa amoxicillin ho tloha timetsong ke li-enzyme - beta-lactamases, tse lumellang ho atolosa bongata ba antibacterial ea amoxicillin.

Ho lokolloa butle butle ha amoxicillin ho tokiso ea Augmentin ® SR ho lumella ho boloka kutloelo-bohloko ea mathata ao S. pneumoniaemoo ho hanyetsa ha amicillin ho bakoang ke liprotheine tse tlamisang penicillin S. pneumoniae, kapa PRSP).

Se latelang ke ts'ebetso ea motsoako oa amoxicillin le clavulanic acid in vitro.

Bacteria e atisang ho ba teng ha e kopana le amoxicillin le clavulanic acid

Lifofane tse khothatsang: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus pneumoniae 1,2, Streptococcus pyogene 1,2, Streptococcus agalactiae 1,2, sehlopha sa streptococcus Viridans 2, Streptococcus spp. (tse ling beta hemolytic streptococci) 1,2, Staphylococcus aureus (tebileng le methicillin) 1, Staphylococcus saprophyticus (e amehang ka methicillin), coagulase-negative staphylococci (e amehang ka methicillin).

Lirosa tse senang maikutlo: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Tse ling: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Li-anaerobes tse ntle le tse ntle: Clostr> ho kenyeletsa Peptococcus niger, magnus ea Peptostreptococcus, micros ea Peptostreptococcus.

Li-anaerobes tsa Gram-negative: Bactero> ho kenyeletsa Bactero> ho kenyeletsa Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Bacteria eo ka eona e ileng ea hanyetsa motsoako oa amoxicillin le clavulanic acid e kanna ea ba teng

Lirosa tse senang maikutlo: Escherichia coli 1, Klebsiella spp., ho kenyelletsa Klebsiella oxetoca, Klebsiella pneumoniae 1, Proteus spp., ho kenyelletsa Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Lifofane tse khothatsang: Corynebacterium spp., Enterococcus faecium.

Bacteria e hanyetsanang ka tlhaho le motsoako oa amoxicillin le clavulanic acid

Lirosa tse senang maikutlo: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Tse ling: Chlamydia spp., ho kenyelletsa Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Bakeng sa mefuta ena ea likokoana-hloko, ho sebetsa hantle ha kliniki ho kopantseng amoxicillin le clavulanic acid ho bontšitsoe lithutong tsa bongaka.

2 Likhahla tsa mefuta ena ea libaktheria ha li hlahise beta-lactamase. Sensitivity le amoxicillin monotherapy e fana ka maikutlo a tšoanang le a kopantsoeng ea amoxicillin le clavulanic acid.

Ho hanyetsa sefapano. Amoxicillin e bonts'a ka kotloloho khanyetso ea sefapano le lithibela-mafu tse ling tsa beta-lactam, hammoho le motsoako oa lithibela-mafu tsa beta-lactam le li-beta-lactamase inhibitors le cephalosporins.

Mekhoa ea ho hanyetsa. Clavulanic acid e sireletsa amoxicillin liphellong tse mpe tsa beta-lactamases. Ho lieha ho lokisoa ha metsoako e sebetsang ea sethethefatsi sa Augmentin ® SR ho eketsa katleho ea matlafatso ea tlhaho khahlanong le likokoana-hloko tseo ho hanyetsa ha tsona ho bakoang ke ho fetoloa ha liprotheine tse tlamang penicillin.

Mofumahali

Lithako ka bobeli tse sebetsang tsa Augmentin ® SR, amoxicillin le clavulanic acid, li qhibiliha hantle ka litharollo tsa metsi ka pH ea mmele, 'me li huloa ka potlako le ka botlalo ho tsoa pampiring ea gastrointestinal kamora tsamaiso ea molomo. Ho fufuleloa hoa lintho tse mafolofolo ho nepahetse haeba u ka sebelisa moriana qalong ea lijo.

Ka tlase ke paramethara ea pharmacokinetic ea amoxicillin le clavulanic acid kamora ho nka matlapa a mabeli. Augmentin ® SR ke baithaopi ba phetseng hantle qalong ea lijo.

Karolelano ea litekanyetso tsa pharmacokinetic

Clavulanic asiti