(lebitso la bobeli ke alpha lipoic).

Sesebelisoa sa mantlha ke antioxidant e hlokoang ke 'mele bakeng sa ts'ehetso e felletseng ea bophelo.

Mafu ao ho bonahatsoang taolo ea 'ona, likotsi tsa joala ba likutu tsa methapo ea kutlo, ho taha setopo sa mmele haholo. Karolo e itseng ea asiti ena 'meleng e hlahisoa ka boithatelo, empa ha lilemo li ntse li feta, boemo ba tlhahiso bo fokotseha,' me tlhoko ea eketseha. Ho tlatselletsa ka alpha lipoic acid ho ka phekola maloetse le ho ntlafatsa bophelo.

Litokisetso tsa Thioctic acid li fumaneha ka mokhoa oa litafole, li-supplement tsa rectal, tharollo e entsoeng ka ente ea ente le ntho e kenelletseng bakeng sa ho hlophisoa ha tharollo. Mekhoa ea meriana e thehiloeng ho alpha-lipoic e fanoa ho litlhare ka meriana feela.

Li-analog tsa Thiogamma li hlahisoa ke lik'hamphani tsa meriana ho linaha tse 'maloa. Re beha lethathamo la tse tloaelehileng 'marakeng oa rona.

• Corilip
• Corilip Neo
• Lipoic acid
• Lipothioxone
• Tiolepta.

• 300 (Jeremane),
• Berlition 600 (Jeremane),
• Neyrolipon (Ukraine),
• Thioctacid 600 T (Jeremane),
• Thioctacid BV (Jeremane),
• Espa Lipon (Jeremane).

Thiogamma kapa Thioctacid?

Thioctacid ke setlhare se tšoanang se thehiloeng holim'a ntho e le 'ngoe e sebetsang.

Sekhahla sa ts'ebeliso ea Thioctacid se nepahetse:

• kalafo ea neuropathies,
• lefu la sebete
• mafu a metabolism,
• atherosmithosis,
• botaoa,
• metabolic syndrome.

Kamora ho hlahloba mokuli le ho fumana tlhahlobo e itseng ea bongaka, ngaka e etsa moriana oa ho sebelisa moriana oo. Ha e le molao, kalafo e qala ka ho tsamaisoa ha ampoules ea lithethefatsi tsa meriana Thioctacid 600 T ka 1600 mg ka matsatsi a 14, ebe ho lateloa ke tsamaiso ea molomo ea Thioctacid BV, 1 letlapeng ka letsatsi pele ho lijo.

Sebopeho sa BV (tokollo e potlakileng) se khona ho nkela liente tse kenang kahare, hobane se lumella karohanyo e matla ea karolo e sebetsang. Nako ea kalafo e telele, hobane 'mele o hloka ho amohela ntho e sebetsang khafetsa, ho netefatsa hore o sebetsa ka botlalo.

Matlapa a Thioctacid

Ha e fanoa kahare ho methapo, litekanyetso tsa ho kena ha lithethefatsi 'meleng li bohlokoa. Ampoule e le 'ngoe e fanoa ka metsotso e 12, hobane sekhahla sa ts'ebetso ea moriana ke 2 ml ka motsotso. Thioctic acid e fetoha bobebe, ka hona, ampoule e tlosoa sephuthelong pele feela e sebelisoa.

Bakeng sa tsamaiso e bonolo, Thioctacid e ka sebelisoa ka mokhoa o hlapolotsoeng. Bakeng sa sena, ampoule ea lithethefatsi e qhibiliha ka 200 ml ea saline ea 'mele, sireletsa botlolo ka khanya ea letsatsi mme e kenelle ka har'a mali ka metsotso e 30. Ha e ntse e boloka ts'ireletso e nepahetseng ho khanya ea letsatsi, Thioctacid e hlapolotsoeng e bolokiloe lihora tse 6.

Ho sebelisa joala ho feta tekano ho bonoa le litekanyetso tse phahameng tsa moriana, tse etsang hore motho a tahoe. Ho bonahatsoa ke ho nyekeloa ke pelo, ho hlatsa, ho opeloa ke hlooho, lefu la ho hloleha ha litho le ho ruruha ha methapo ea methapo, hemolysis le ho tsitsipana.

Tšebeliso ea sethaleng sa kalafo e hatelloa, hobane e lebisa chefo e matla, ho tsitsipana, ho akheha, le sephetho se ka bang kotsi.

Haeba matšoao ana a fumanoa, ho hlokahala sepetlele le ba sepetlele ka nako eo ho shebaneng le tlhakisetso ea detoxation ho hlokahala.

Ha o etsa infusion ea Thioctacid 600 T, litla-morao tse mpe li hlaha ha sethethefatsi se tsamaisoa ka potlako.

Ho fetoha ho ka ba teng, mohlomong keketseho ea khatello ea kelello, makhopho a sefahleho. Haeba mokuli a e-na le mamello ea lithethefatsi ka nako e le 'ngoe, ho ka ba le ponahalo ea lintho tse kulisoang ke lintho tse ling tse amang tlhaho, mohlala, lekhopho la letlalo, ho hlohlona, ​​anaphylaxis, edema ea Quincke. Ho na le menyetla ea ho senyeha hoa liplatelete, ponahalo ea ho tsoa mali ka tšohanyetso, hemorrhage e supang letlalong.

Ha u nka matlapa a Thioctacid B, ka linako tse ling bakuli ba tšoenngoa ke mathata a tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, gastralgia, ho se sebetse hantle mala. Ka lebaka la thepa ea Thioctacid, li-ion tsa tšepe le lintho tse tataisoang ka bonngoe li kopantsoe le tšepe, calcium, magnesium kapa li-mineral complex tse ngata tsaaminerine li loantšitsoe.

Batho ba noang kapa ba noang meriana ho theola tsoekere ea bona ea mali ba lokela ho hopola hore asiti ea thioctic e eketsa lebelo la ts'ebeliso ea tsoekere, ka hona o hloka ho lekola boemo ba hau ba tsoekere haholo le ho fetola litekanyetso tsa lintho tse theolelang tsoekere.

Ka lebaka la tšohanyetso ea metsoako ea lik'hemik'hale e qhibilihang e sa sebetseng, Thioctacid ha e kopane le tharollo ea Ringer, monosaccharides le tharollo ea lihlopha tsa sulfide.

Ha e bapisoa le Tiogamma, Thioctacid e na le litlolo tse fokolang tse fokolang, tse kenyelletsang feela matsoele, ho pepa le ho se mamellane ha likarolo tsa moriana.

Na ho na le letho le theko e tlase hape le betere ho feta Tiogamma? Tlhahlobo ea li-analogues le papiso ea lithethefatsi. Li-analogu tsa Tiogamm le litheko

Tiogamma: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Thiogamma

Khoutu ea ATX: A16AX01

Motsoako o sebetsang: Thioctic acid (Thioctic acid)

Moetsi: Verwag Pharma GmbH & Co KG (Worwag Pharma GmbH & Co KG), Beblingen, Jeremane

Nchafatso ea litlhaloso le foto: 05/02/2018

Thiogammama ke lithethefatsi tse laolang metabolism ea lipid le carbohydrate.

Na ho na le letho le theko e tlase hape le betere ho feta Tiogamma? Tlhahlobo ea li-analogues le papiso ea lithethefatsi. Litaelo tse fetang tekano le litaelo tse ikhethang. Li-analog mabapi le sebopeho le pontšo ea ts'ebeliso

Thiogamma ke sethethefatsi sa antioxidant le metabolic se laolang metabolism ea carbohydrate le lipid.

Ntho e sebetsang ea lithethefatsi ke thioctic (alpha-lipoic) acid. Ke antioxidant ea endo native e tlamang li-radicals tsa mahala. Thioctic acid e thehoa 'meleng ka nako ea oxidative decarboxylation ea alpha-keto acid.

Thioctic acid e laola metabolism ea carbohydrate le lipid, e ntlafatsa ts'ebetso ea sebete mme e matlafatsa metabolism ea cholesterol. E na le hypolipidemic, hypoglycemic, hepatoprotective le hypocholesterolemic effect. E khothaletsa phepo e ntlafalitsoeng ea li-neuron.

Alfa-lipoic acid e thusa ho fokotsa tsoekere ea mali, e eketsa bongata ba glycogen sebete le ho hlola insulin. Ka mochine oa ts'ebetso, e haufi le livithamini tsa sehlopha sa B.

Boithuto mabapi le likhoto tse nang le lefu la tsoekere la streptozotocin le bonts'itseng li bonts'itse hore thioctic acid e fokotsa sebopeho sa lihlahisoa tsa glycation, e ntlafatsa phallo ea mali a endoneural, mme e eketsa boemo ba li-antioxidants tsa 'mele tse kang glutathione. Bopaki ba boithuto bo fana ka maikutlo a hore thioctic acid e ntlafatsa ts'ebetso ea "peripheral neuron".

Sena se sebetsa le lits'oants'o tsa maikutlo ho lefu la tsoekere la polyneuropathy, joalo ka dysesthesia, paresthesia (ho chesa, ho utloa bohloko, ho akheha, ho fokotseha ha kutloisiso). Litlamorao li netefalitsoe ke liteko tsa tleliniki ea multicenter tse entsoeng ka 1995.

Mefuta ea tokollo ea lithethefatsi:

• Matlapa - 600 mg ea ntho e sebetsang ho e 'ngoe le e' ngoe.
• Tharollo ea tsamaiso ea botsoali ea 3%, li-ampoule tsa 20 ml (ka ampoule 600 mg ea ntho e sebetsang),
• Thiogamm-turbo - tharollo bakeng sa infusion ea botsoali 1.2%, li-vials tse 50 ml (ka botlolong e le 'ngoe ea 600 mg ea ntho e sebetsang).

Matšoao a ho sebelisoa

Ke eng e thusang Tiogamma? Fana ka moriana maemong a latelang:

• Lefu la sebete sa mafura (lefu la mafura a sebete),
• Hyperlipidemia ea tlhaho e sa tsejoeng (mafura a phahameng a mali)
• Chefo ea limela tse putsoa (tšenyo e nang le chefo ea sebete),
• Ho hloleha ha sebete
• Lefu la sebete la joala le litlamorao tsa lona,
• Hepatitis ea tšimoloho efe kapa efe,
• Hepatic encephalopathy,
• Cirrhosis ea sebete.

Litaelo tsa ho sebelisa Thiogamma, litekanyetso

Matlapa a nooa ka molomo, ka mpeng e se nang letho, a hlatsuoa ka metsi a manyane.

Kamora selemo, tsela ea kalafo e ka phetoa makhetlo a 2-3.

Litlhare li fanoa ka iv ka tekanyo ea 600 mg / ka letsatsi (1 amp. Tsepamisa maikutlo bakeng sa ho hlophisoa ha tharollo ea infusion ea 30 mg / ml kapa botlolo e le 'ngoe ea tharollo ea infusion ea 12 mg / ml).

Ha o etsa infusion ea methapo, lithethefatsi li lokela ho tsamaisoa butle, ka tekanyo e sa feteng 50 mg / min (e lekanang le 1,7 ml ea ho tsepamisa mohopolo bakeng sa ho hlophisoa ha tharollo ea infusion ea 30 mg / ml).

Lokisetsa tharollo ea infusion - litaba tsa ampoule e le 'ngoe ea mohopolo li lokela ho kopanngoa le 50-250 ml ea tharollo ea chloride ea 0,9%. Botoro e nang le tharollo e entsoeng hantle e koahetsoe ka sekoaelo se sirelelitseng bobebe, se tlisoang ke moriana ka botlalo. Tharollo e lokiselitsoeng e ka bolokoa ha ho feta lihora tse 6.

Haeba ho sebelisoa sesebelisoa sa infusion se itokiselitseng, botlolo ea moriana e ntšoa ka lebokoseng ebe hang-hang e koaheloa ka lebokose le sireletsang. Selelekela se etsoa ka kotloloho ho tsoa botlolong, butle - ka lebelo la 1,7 ml / motsotso.

Litlamorao

Thiogamma e kanna ea amahanngoa le litlamorao tse latelang:

Ho tsoa ho ts'ilo ea lijo: ha u sebelisa moriana kahare - dyspepsia (ho kenyelletsa ho nyekeloa pelo, ho hlatsa, ho opeloa ke pelo).

• Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: ka seoelo (kamora taolo ea iv) - lits'oants'o, diplopia, ka tsamaiso e potlakileng - khatello e matla ea intracranial (ponahalo ea maikutlo a boima hloohong).
• Ho tsoa tsamaisong ea mali ea mali: ka seoelo (kamora ho tsamaisoa ha iv) - bua ka hemorrhages ka mucous membrane, letlalo, thrombocytopenia, hemorrhagic rash (purpura), thrombophlebitis.
• Ho tsoa ts'ebetsong ea ho hema: ka ho potlakela ho kenella / kenyelletsong, ho hema ka thata hoa khoneha.
• Litlamorao: urticaria, systemic reaction (ho fihlela nts'etsopele ea anaphylactic shock).
• Tse ling: hypoglycemia e ka hlaha (ka lebaka la ho ntlafatsoa ha tsoekere).

Contraindication

Thiogammia o kopantsoe le linyeoe tse latelang:

• bana le bacha ba ka tlase ho lilemo tse 18,
• nako ea kemaro
• nako ea kemolo
• glucose-galactose malabsorption, khaello ea lactase, ho hloka mamello ea lefa la galactose (bakeng sa matlapa),
• hypersensitivity ho metsoako ea mantlha kapa e thusang ea lithethefatsi.

Khahlano le semelo sa tšebeliso ea lithethefatsi, joala bo ke ke ba nkuoa, hobane tlasa ts'usumetso ea ethanol, monyetla oa ho ba le mathata a maholo ho tsoa ts'ebetsong ea methapo le tšilo ea lijo li eketseha.

Litheko makaleng a litlhare a Moscow: Tharollo ea Thiogamma 12 mg / ml 50 ml - ho tloha 197 ho isa ho li-ruble tse 209. Matlapa a 600 mg 30 likhomphutha. - ho tloha ho li-ruble tse 793 ho isa ho tse 863.

Tsoela hole le bana, u sirelelitsoe ke khanya, ka mocheso o fihlang ho 25 ° C. Bophelo ba Shelf ke lilemo tse 5. Ka litlama tsa meriana, lengolo la ngaka lea fumaneha.

Litšoantšiso tsa thiogamm ea lithethefatsi li hlahisoa, ho latela polelo ea bongaka e bitsoang "li-syonyms" - lithethefatsi tse fetohang tse nang le ntho e le 'ngoe kapa tse ngata tse tšoanang ka litlamorao tsa tsona' meleng. Ha u khetha li-synonyms, u se ke ua nahana feela ka litšenyehelo tsa bona, empa hape le naha ea tlhahiso le botumo ba moetsi.

Tlhaloso ea lithethefatsi

Ha e le coenzyme ea mitochondrial multenzyme complexes, e ameha ka oxidative decarboxylation ea pyruvic acid le alpha-keto acid. E thusa ho fokotsa tsitsipano ea tsoekere maling le ho eketsa sethibela sa glycogen sebeteng, hammoho le ho hlola khanyetso ea insulin.

E nka karolo taolong ea metabolism ea lipid le lik'habohaedreite, e ama metabolism ea cholesterol, e ntlafatsa ts'ebetso ea sebete, e na le phello ea ho fetoha ha chefo ka salate e boima ea tšepe le lino tse tahang. E na le litla-morao tsa hepatoprotective, hypolipidemic, hypocholesterolemic le hypoglycemic. E ntlafatsa li-neurons tsa trophic.

Ho tsoekere ea lefu la tsoekere, thioctic acid e ntlafatsa phallo ea mali, e eketsa boleng ba glutathione ho boleng ba mmele, bo hlahisang ntlafatso maemong a sebetsang a methapo ea methapo ea kutlo e amanang le lefu la tsoekere la polyneuropathy.

Lethathamo la li-analogues

Ela hloko! Lenane le na le li-syonyms tsa Tiogamma, tse nang le sebopeho se ts'oanang, kahoo o ka khetha phetiso ka boeena, o ntse o nahanne ka sebopeho le tekanyo ea moriana o boletsoeng ke ngaka. Fana ka likhetho ho bahlahisi ba tsoang USA, Japan, Europe Bophirimela, hammoho le lik'hamphani tse tsebahalang tse tsoang Europe Bochabela: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Baeti ba 28 ba tlaleha ho ja letsatsi le letsatsi

Ke lokela ho nka Thiogamma hangata hakae?
Boholo ba batho ba atisang ho buoa hangata ba sebelisa lithethefatsi sena ka nako e le ngoe ka letsatsi. Tlaleho e bontša hore hangata ba arabelang litlhare tse ling ba sebelisa moriana ona joang.

Baeti ba 33 ba tlalehile litekanyetso

Baeti ba bahlano ba tlalehile matsatsi a ho felloa ke nako

Ho nka nako e kae Thiogamma a utloa ntlafatso boemong ba mokuli?
Barupeluoa ba bileng teng maemong a mangata kamora khoeli e le ngoe ba utloile ntlafatso. Empa sena se kanna sa lumellana le nako eo u tla ntlafala ka eona. Ikopanye le ngaka ea hau hore na u hloka moriana ona ho fihlela neng. Tafole e ka tlase e bonts'a sephetho sa phuputso e entsoeng qalong ea ketso e sebetsang.

Baeti ba robeli ba tlaleha linako tsa kamohelo

Ke nako efe e nepahetseng ea ho nka Tiogamm: ka mpeng e se nang letho, pele, kamora kapa ka lijo?
Basebelisi ba webosaete hangata ba tlaleha ho nka moriana ona ka mpeng e se nang letho. Leha ho le joalo, ngaka e ka khothaletsa nako e 'ngoe. Tlaleho e bontša ha bakuli ba bang ba buisanoeng ba sebelisa moriana.

Lipehelo tsa matsatsi a phomolo

Tlhahisoleseling e leqepheng lena e netefalitsoe ke setsebi sa bophelo bo botle Vasilieva E.I.

Thiogamma ke mokhoa oa ho laola metabolism ea carbohydrate le lipid. Fana ka litlhare tsena ho batho ba lefu la tsoekere. Moetso o kenyelletsa thioctic acid. E fumaneha ka mokhoa oa litafole, e tsepamisa maikutlo ho fumana tharollo le tharollo ka botsona. Setlhare se fanoa ka taelo ea ngaka.Nahana ka letšoao le ka sehloohong, hammoho le thiogamma, litaelo tsa tšebeliso, theko, litekolo, li-analogues.

Lefu la tsoekere la polyneuropathy

Matšoao a sebelisang Tiogamma 600 ke lefu la tsoekere la polyneuropathy. E qala ho batho ba nang le lefu la tsoekere. E ka etsahala le pele lefu la lefu le hlaha. E iponahatsa e le phetoho lithong tsa manonyeletso, bohloko bo boholo bo fapaneng le matla, maikutlo a tepelletsang, letsoalo la ho chesoa hohle 'meleng, empa hangata e le maotong.

Setlhare se fanoa ho felisa matšoao, ho ntlafatsa methapo ea kutlo, le ho thibela nts'etsopele ea mathata, ho kenyeletsa le liso tsa ka mpeng.

Seo lingaka li se buang ka likhoele

Ngaka ea Saense ea Bongaka, Ngaka e Butsoeng ka Plaston Morozov EA:

Ke qetile lilemo tse ngata ke buuoa ka polasetiki. Batho ba bangata ba tummeng ba neng ba batla ho shebahala ba le banyenyane ba ile ba feta ka nna. Hajoale, ho buuoa ka polasetiki ho lahleheloa ke bohlokoa ba eona hobane saense ha e eme, mekhoa e mecha le ho feta ea ho nchafatsa 'mele e bonahala,' me tse ling tsa tsona li sebetsa hantle. Haeba u sa batle kapa u se na monyetla oa ho etsa opereishene ea polasetiki, ke khothaletsa mokhoa o sebetsang hantle empa o le litšenyehelo tse tlase ka moo ho ka khonehang.

Bakeng sa selemo se fetang 1 hona joale, setlhare sa mohlolo bakeng sa ntlafatso ea letlalo NOVASKIN, se ka fumanoang, se bile 'marakeng oa Europe MAHALA . Mabapi le ts'ebetso, e makhetlo a 'maloa e phahame ka ente ea Botox, re sa bue ka mefuta eohle ea litlolo. Ho bonolo ho e sebelisa mme ketso ea eona ea bohlokoa ka ho fetisisa eo u tla e bona hang-hang. Ntle le ho fetelletsa lintho, ke tla re mabenyane a manyenyane le a tebileng, mekotla e ka tlas'a mahlo e feta hang-hang. Ka lebaka la ts'ebetso e ka hare, letlalo le khutlisetsoa ka botlalo, le nchafalitsoe hape, liphetoho li mpa li le ngata haholo.

Lisosa tsa lefu lena li nkuoa e le maemo a bakoang ke kalafo ea lefu la tsoekere. Ka ho khetheha:

• Tsoekere ea mali e baka likhathatso tse tebileng ho potoloha le 'mele.
• Khaello ea phepo e nepahetseng, hypoxia,
• Ho monya ha monate oa limatlafatsi le livithamini,
• Ho bola khafetsa ha lefu la tsoekere.

Ka nts'etsopele ea lefu la tsoekere, polyneuropathy e tsitsitse mme qetellong e ka se fetohe. Ho na le mehato e 'maloa ea lefu lena: subclinical, clinical.

Boemong ba subclinical, e leng bohato ba pele, hangata ha bo hlokomele matšoao - ho ba le letsoalo le sa tloaelehang.

Boemong ba bobeli, lingaka, matšoao a fapakaneng a se a ntse a bonahetse ho latela sebopeho sa lefu lena - bohloko bo hlobaetsang, bohloko bo sa foleng, bohloko bo se nang bohloko, amyotrophic.

Mohatong oa boraro, mathata a se a ntse a eketseha. E 'ngoe ea tsona ke liso ka leoto le ka tlase. Ho 15% ea bakuli, libaka tse amehileng li tlameha ho tlosoa, ke hore, ho khaoloa ho etsoa. Polyneuropathy e tšoaroa ka lithethefatsi tse 'maloa, ho kenyelletsa:

• Li-vithamine
• Alpho-Lipolic Acid,
• Aldose reductase inhibitors,
• Moriana oa bohloko
• Actovegin,
• Lithibela-mafu (haeba ho na le moemeli ea tšoaetsanoang)
• Litokisetso tsa calcium le potasiamo.

Pharmacokinetics le bohato ba pharmacological

Sena ke moemeli oa metabolic o nang le antioxidant ea endo native e tlamang li-radicals tsa mahala. Ka thuso ea eona, lintho tse hlokahalang le asiti li hlophisitsoe 'meleng oa mokuli. E boetse e sebetsa joalo ka coenzyme, e nka karolo lits'ebetsong tsa oxidative. E thusa ho fokotsa tsoekere ea mali le ho eketsa maemo a glycogen bokong. Ka thuso ea eona, ho ka khona ho hlola ho hanyetsa insulin.

Thioctic acid ho Thiogamma e ts'oana le ho biochemistry ho livithamini tsa B. Ba thusa ho nka karolo ho carbohydrate le lipid metabolism, ho matlafatsa metabolism ea cholesterol, le ho ntlafatsa ts'ebetso ea sebete. Kahoo, phello e sirelletsang ho sebete e hlaha, hammoho le litlamorao tsa hypogholecerolemic le hypolipidemic. Ho li-neurons, trophism ea ntlafala. Ho fanoa ka theko, litaelo tsa tšebeliso, Thiogamma ka mokhoa oa tharollo bakeng sa iv e thusa ho fokotsa litla-morao mme e thusa haholo ho ntlafatsa bophelo bo botle.

Kamora ho nka letlapa la Tiogamma, thioctic acid e batla e kenelletse ka botlalo ka popelong ea mala. Haeba u nka letlapa ka nako e le ngoe le lijo, joale mokhoa oa ho monya o fokotsehile haholo, o nka hora. Ho feta moo, bioavailability ke 30%. Ka ente ea methapo, Thiogamm, ho ea ka lingaka, e kenella ka botlalo ka metsotso e 10-11.

Lithethefatsi li feta ka tsela ea pele-pele, li etsa metabolites. Li hlahisoa ke liphio ka 90%. Bophelo ba halofo ke metsotso e 20-50, ho latela litšobotsi tsa 'mele oa mokuli.

Kopo

Moriana o fanoa ka molomo ho 300-600 mg hang ka letsatsi. Matlapa a nkuwa ntle le ho hlafuna ka metsi a manyane. Moriana o tšeloa ka sekhahla ka bongata ba 600 mg. Qalong ea kalafo, ho khothaletsoa tsamaiso ea methapo ea moriana. e etsoa letsatsi le letsatsi bakeng sa libeke tse 2-4, ho latela lipontšo le litaelo tsa ngaka. Kamora hore moriana o fanoe ka molomo ka mokhoa oa pilisi ea Tiogamm ka boholo ba 300-600 mg. Ha moriana o fanoa ka methapo, ho hlokahala hore o tsamaise butle butle kamoo ho ka khonehang - 50 mg / min.

Ho latela litaelo, Thiogamma Turbo e tsamaisoa ka mokhoa oa batsoali haeba e le tharollo.

Kenya kopo maemong ao tlolo ea molao ea kutlo e seng e boletsoe mme e amana le lefu la tsoekere le ferekaneng.

Ha mohopolo o kopantsoe le solvent, moemeli o fuoa hang-hang ho boloka ts'ebetso ea eona e sebetsa. Etsa bonnete ba hore o sireletsa tharollo mahlaseling a letsatsi.

Ka foromo ea letlhare, moriana o sebelisoa joalo ka ha o laetsoe ke ngaka, hangata hangata kamora ho kenella. Nako ea kalafo ke likhoeli tse 1-4. Litaelo tsa ho sebelisa Thiogamm li re moriana o ka nooa ho sa tsotelehe lijo, empa ka lijo, ts'ebetso ea ho monya e ea fokotseha, joalo ka ha ho boletsoe kaholimo.

Ka hona, ho buisana le ngaka e eang ho hlokahala ka taba ena.

Ho lokisa le ho tsamaisa tharollo ea infusion

Ho lokisa tharollo ea Thiogamma bakeng sa tsamaiso ea methapo, 1 ampoule ea lithethefatsi ka 20 ml (e lekanang le 600 mg ea thioctic acid) e kopantsoe le 50-250 ml ea 09% sodium chloride solution. E tsamaisoa e le infusion nako e fetang metsotso e 20-30. Li entsoe ka libotlolo tse khethehileng tse kentsoeng meqomong e sirelelitsoeng ka leseli e koaheletsoeng ka moriana (li sootho ka 'mala ebile li entsoe ka polyethylene e khethehileng).

Haeba infusions e etsoa ho tsoa ho li-ml tsa 50 ml, joale ts'ebetso e bonoa ka kotloloho ho tsoa botlolong eo tharollo e fumanehang ho eona. E boetse e lokela ho beoa kahare e khethehileng ea tšireletso e entsoeng ka polyethylene e ntšo.

Litla-morao

Litla-morao kamora ho sebelisa meriana le tsona li teng. Ho na le tse fetang ka botsona le ho nka mehato ea ho li felisa ho na le boikhethelo:

• Phekolo ea ka mpeng: tsitsipano ea pelo, ho hlatsa, ho nyekeloa - ke hore, dyspepsia,
• CNS: diplopia, ho tsitsipana, le taolo e potlakileng ea moriana o kenang - khatello e eketsehileng, maikutlo a ho tepella hloohong,
• Hematopoietic Sisteme: hemorrhages e kenang liseleng tsa mucous, lehetleng la hemorrhagic, thrombocytopenia le thrombophlebitis,
• Sistimi ea khalemelo: Tsamaiso e potlakileng - ho hema ka thata.

Empa ho na le maemo ao ho 'ona ho ka hlokahalang thuso e tebileng. Mohlala, mokuli a ka ba le hypoglycemia ka lebaka la keketseho ea ho monya ha tsoekere, hammoho le ho haptjoa hoa lintho tse ling ho fihlela ho tsitsipana ha anaphylactic.

Ha ho na le li-contraindication tse ngata ho Thiogamma matlapeng kapa tharollong. Ha e le hantle, ana ke litšobotsi tsa 'mele oa motho ka linako tse itseng tsa bophelo:

• Lebone
• Boimana
• Lilemo tsa bana
• Hypersensitivity.

Ts'ebeliso ea lithethefatsi Tiogamm hape ha e khonehe ho batho ba nang le bothata ba:

• Ho tsoa ho lactate cidosis (le haeba ho se na eona, empa ho bonolo ho e qholotsa),
• Tlolo e matla ea sebete le liphio, tse sebetsang le ho tlosa sethethefatsi,
• Myocardial infarction, e maemong a hlobaetsang (litla-morao tse matla li ka hlaha ka lebaka la bofokoli ba mmele),
• Ho hloleha ho sebetsa ha pelo kapa ho phefumoloha,
• Ho tahi e sa foleng,
• Ho omella
• Ho ferekana hoholo ho potoloha ha mali sebakeng sa boko (ka lebaka la kotsi ea litlamorao ka tsela ea khatello ea methapo).

Mabapi le bongoana, ho loketse ho hlakisa hore ha ho na li-contraindication tse ikhethang, ha ho na lithuto tse entsoeng sehlopheng sena sa batho.

Thiogamma bakeng sa sefahleho

Ka mokhoa o makatsang, empa pheko e tebileng joalo ka thiogamma bakeng sa sefahleho, ho ea ka maikutlo a litsebi tsa cosmetologists, le eona e ka sebelisoa. Ho latela bona, ena ke pheko e ntle haholo ea ho loants'oa wrinkle e tla u thusa ho nchafatsa kapele.

Alpho-lipolic acid e thusa ho fokotsa ho tsofala, ho tlosa marang-rang, ho nchafatsa letlalo, ho kokobetsa ho ruruha, ho fokotsa pores joalo-joalo.

Thiogamma bakeng sa sefahleho e sebelisoa ka mokhoa oa li-dropers, ho ahlola ka litlhahlobo tsa bareki, le ka ntle. Mokhoa o bonolo ka ho fetisisa o sebetsa letlalong ka pane ea k'hothone. Thupelo ke matsatsi a 10, mme ts'ebetso e etsoa letsatsi le letsatsi.

Motho e mong o khothaletsa ho etsa ts'ebetso ena habeli ka letsatsi, empa tšebeliso ea lithethefatsi joalo ha e fanoe, ka hona ho ka se khonehe ho bolela karabelo ea mmele. Ka kakaretso, thiogamma bakeng sa sefahleho e fumane litlhahlobo tse ntle. Empa ho na le basebelisi ba marang-rang ba neng ba bolela hore khafetsa ba ba le litlamorao tsa tlhaho ea ho kulisa - haholo-holo urticaria esita le ho ts'oaroa ha anaphylactic. Ka hona, sesebelisoa ha se khothalletsoe merero e joalo.

Lithethefatsi tsa Metabolic. Thioctic (α-lipoic) asiti, e leng antioidos ea tlhaho (e kopanyang li-radicals tsa mahala), e entsoe ka 'mele ka oxidative decarboxylation ea alpha-keto acid. Ha e le coenzyme ea mitochondrial multenzyme complexes, e ameha ka oxidative decarboxylation ea pyruvic acid le alpha-keto acid. E thusa ho fokotsa tsitsipano ea tsoekere maling le ho eketsa sethibela sa glycogen sebeteng, hammoho le ho hlola khanyetso ea insulin.

E nka karolo taolong ea metabolism ea lipid le lik'habohaedreite, e ama metabolism ea cholesterol, e ntlafatsa ts'ebetso ea sebete, e na le phello ea ho fetoha ha chefo ka salate e boima ea tšepe le lino tse tahang. E na le litla-morao tsa hepatoprotective, hypolipidemic, hypocholesterolemic le hypoglycemic. E ntlafatsa li-neurons tsa trophic.

Ho tsoekere ea lefu la tsoekere, thioctic acid e ntlafatsa phallo ea mali, e eketsa boleng ba glutathione ho boleng ba mmele, bo hlahisang ntlafatso maemong a sebetsang a methapo ea methapo ea kutlo e amanang le lefu la tsoekere la polyneuropathy.

Kamora ho tsamaisoa ka molomo, thioctic acid e potlaka haholo mme e batla e ananeloa ka botlalo ho tsoa ho tšilo ea lijo. Ha ho nkoa ka lijo, ho monya hoa fokotseha. Nako ea ho fihla C max (4 μg / ml) ke metsotso e ka bang 30. Bioavailability - 30-60% ka lebaka la phello ea "karolo ea pele" ka sebete.

E tšeloa ka har'a sebete ka lehlakoreng le leng oxidation le conjugation.

Thioctic acid le metabolites ea eona li hlahisoa ke liphio (80-90%), ka tekanyo e nyane - ha e fetohe. T 1/2 ke 25 min.

Abela ka hare ho 600 mg (1 tab.) 1 nako / letsatsi.

Matlapa a nkuoa ka mpeng e se nang letho, ntle le ho hlafuna, ka mokelikeli o fokolang.

Nako ea kalafo ke matsatsi a 30-60, ho latela boholo ba lefu lena. U ka pheta-pheta nako ea kalafo makhetlo a 2-3 ka selemo.

Boemo ba karabelo e mpe bo fanoa ho latela sehlopha sa WHO:

Ketso ea pharmacological

Thioctic acid (alpha lipoic acid) - e leng antioxidant ea endo native (e kopanyang li-radicals tsa mahala), e thehoa 'meleng ka oxidative decarboxylation ea alpha ketoxylate. Ha e le coenzyme ea mitochondrial multenzyme complexes, e ameha ka oxidative decarboxylation ea pyruvic acid le alpha-keto acid.

E thusa ho fokotsa khatello ea "glucose" maling le ho eketsa glycogen sebete, hammoho le ho hlola insulin. Mofuta oa ketso ea biochemical o haufi le livithamini tsa B.

E nka karolo taolong ea metabolism ea lipid le carbohydrate, e matlafatsa metabolism ea cholesterol, e ntlafatsa ts'ebetso ea sebete. E na le hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. E ntlafatsa li-neurons tsa trophic.

Ts'ebeliso ea letsoai la trometamol la thioctic acid ho tharollo bakeng sa tsamaiso ea iv (ho ba le karabelo e sa nke lehlakore) ho ka fokotsa botebo ba karabelo e mpe.

Litlamorao

Litla-morao tse o utloisang bohloko (urticaria, pruritus, anaphylactic shock). Ho nyekeloa ke pelo le ho opeloa ke pelo (ha ho nkuoa ka molomo, hangata ha ho sebelisoa letsoai la trometamol).

Ka tsamaiso ea methapo ea methapo, hemorrhages ea lisele tsa mucous, letlalo, thrombocytopathy, hemorrhagic rash (purpura), thrombophlebitis, khatello e eketsehileng ea intracranial (tsamaiso e potlakileng), ho hema ka thata, hypoglycemia (ka lebaka la ho ts'oaroa ha glucose), ho tsitsipana, diplopia, intracranial khatello ea mali

Thiogamma kapa Berlition?

Moqapi oa analog o ngolisitsoe Jeremane, ntho e sebetsang e rekoa Chaena. Ho na le maikutlo a fosahetseng a hore Berlition e na le chelete e ngata ho feta chelete, empa sena ha se nnete.

Li-ampoules tsa Berlition

Mofuta oa ho lokolloa ke lilakane le matlapa a nang le litekanyetso tsa 300 mg, palo ea matlapa a sephutheloaneng a fokola haholo, ho bolelang hore o tlameha ho sebelisa tloaelo e habeli ea meriana ho fumana kalafo ea letsatsi le letsatsi ea alpha-lipoic acid. Ka lebaka leo, litheko tsa thupelo li nyoloha.

Thiogamma kapa Oktolipen?

Analog ea tlhahiso ea Serussia ka theko e ntle bakeng sa ho paka. Empa ha u bala litšenyehelo tsa thupelo, ho hlakile hore theko ea kalafo e maemong a theko e phahameng haholo.

Bophahamo ba Oktolipen bo nyane haholo, kaha bo na le matšoao a mabeli feela a ho khethoa - lefu la tsoekere le joala la joala ba joala.

Ka thepa ea biochemical e tšoanang le livithamini tsa sehlopha sa B.

Sokolla foromo le sebopeho

• Tharollo ea infusion: botala bo bosehla bo bosehla bo bosehla bo bosehla bo bosehla kapa bo bosehla (50 ml ka botlolong ea khalase e lefifi, 1 kapa 10 ka lebokoseng la karete ea karete)
• tsepamisa maikutlo bakeng sa tharollo ea infusion: tharollo e hlakileng ea 'mala o botala bo bosehla (20 ml ka ampoule e khanyang ea khalase, li-ampoules tse 5 ka mokotleng, 1, 2 kapa 4 pallet lebokoseng la karete.
• matlapa a koahetsoeng: oblong, khokahano mahlakore ka bobeli, a bobebe a 'mala ka' mala o mosoeu le o mosehla o nang le matla a fapaneng, a nang le likotsi ka mahlakoreng ka bobeli, karolo e bobebe ea mosehla e bonahala karolong ea sefapano (li-pcs tse 10 ka blister, 3, 6 kapa malepa a 10 ka lebokoseng la karete.

Ntho e sebetsang ke thioctic acid:

• 1 ml ea tharollo - 12 mg (600 mg ka botlolo e le 'ngoe),
• 1 ml ea ho tsepamisa mohopolo - 30 mg (600 mg ho ampoule e le 1),
• Letlapa le le 1 - 600 mg.

• Tharollo: macrogol 300, meglumine, metsi a ka enteng,
• tsepamisa maikutlo: macrogol 300, meglumine, metsi a ente,
• matlapa: colloidal silicon dioksidi, croscarmellose sodium, microcrystalline cellulose, simethicone (dimethicone le colloidal silicon dioxide ka karo-karolelano ea 94: 6), lactose monohydrate, talc, magnesium stearate, hypromellose, qopollo ea sosolone, scrl sosec.

Litaelo tse khethehileng

Nakong ea kalafo, ho hlokahala hore u hane ka tieo ho nka ethanol.

Ho bakuli ba nang le lefu la tsoekere, haholo-holo qalong ea kalafo, ho hlokahala hore ho hlahlojoe tsoekere e maling khafetsa.

Lithethefatsi li na le kutloisiso, ka hona, li-ampoules li lokela ho tlosoa polasetiking hang feela pele li sebelisoa.

Tšebelisano

Fokotsa ts'ebetso ea cisplatin.

E ntlafatsa litlamorao tsa lithethefatsi tsa insulin le molomo.

E hanana le tharollo ea ringer le dextrose, likhomphutha (ho kenyeletsa le tharollo ea tsona) tse arabelang ka ho se lumellane le lihlopha tsa SH, ethanol.

Ethanol le metabolites ea eona li eketsa kotsi ea litla-morao.

Pharadodynamics

Ntho e sebetsang ea lithethefatsi ke thioctic (alpha-lipoic) acid. Ke antioxidant ea endo native e tlamang li-radicals tsa mahala. Thioctic acid e thehoa 'meleng ka nako ea oxidative decarboxylation ea alpha-keto acid. Ke coenzyme ea li-complexenzyme tse ngata tsa mitochondria mme e kenella ho oxidative decarboxylation ea alpha-keto acid le pyruvic acid.

Alfa-lipoic acid e thusa ho fokotsa tsoekere ea mali, e eketsa bongata ba glycogen sebete le ho hlola insulin. Ka mochine oa ts'ebetso, e haufi le livithamini tsa sehlopha sa B.

Thioctic acid e laola metabolism ea carbohydrate le lipid, e ntlafatsa ts'ebetso ea sebete mme e matlafatsa metabolism ea cholesterol. E na le hypolipidemic, hypoglycemic, hepatoprotective le hypocholesterolemic effect. E khothaletsa phepo e ntlafalitsoeng ea li-neuron.

Ha u sebelisa letsoai la meglumine ea alpha-lipoic acid (e nang le karabelo e sa nke lehlakore) litharolong tsa tsamaiso ea methapo, ho teba ha litlamorao ho ka fokotsoa.

Tharollo bakeng sa infusion le ho tsepamisa mohopolo ha ho etsoa tharollo ea infusion

Tharollo, ho kenyelletsa le e lokiselitsoeng ho tsoa ho tsepamiso, e fanoa ka matla.

Tekanyetso ea letsatsi le letsatsi ea Thiogamm ke 600 mg (botlolo e le 'ngoe ea tharollo kapa ampoule e le' ngoe ea mohopolo).

Setlhare sena se fanoa ka metsotso e 30 (ka tekanyo e ka bang 1,7 ml ka motsotso).

Ho hlophisoa ha tharollo ho tsoa botebong ba pelo: se ka hare ho ampoule e le 'ngoe se kopantsoe le 50-250 di ml tse 0,9% sodium chloride solution. Hang-hang ka mor'a ho itokisa, tharollo e lokela ho koaheloa hang-hang le kesi e kenyelitsoeng ka lebone. Boloka tse fetang lihora tse 6.

Ha o sebelisa tharollo e entsoeng ka mokhoa o lokiselitsoeng, ho hlokahala hore o tlose botlolo ka har'a pakete ea karete ebe oe koahela hang-hang ka nyeoe e sireletsang. Ho kenella ho lokela ho etsoa ka kotloloho ho tsoa ho vial.

Nako ea kalafo ke libeke tse 2-5. Haeba ho hlokahala, tsoela pele ka kalafo, mokuli o fetisetsoa ka foromo ea moriana oa lipilisi.

Tharollo 'me u tsepamise maikutlo

• ho tloha tsamaisong ea endocrine: ho fokotseha ha khatello ea tsoekere maling maling (litšitiso tse bonoang, ho fufuleloa ho feteletseng, ho tsekela, hlooho ea hlooho),
• lehlakoreng la tsamaiso ea methapo e kholo: ho tlola kapa ho fetola tatso, ho tsitsipana, ho tsietsana ha sethoathoa,
• Ho tsoa ho sheropoietic system: hemorrhagic rash (purpura), thrombocytopenia, thrombophlebitis, hempoint hemorrhages letlalong le mucous membrane,
• letlalong la letlalo le linama tse tšetseng lintho tse ling: eczema, ho hlohlona, ​​lekhopho,
• lehlakoreng la sebono sa pono: diplopia,
• karabelo: "urticaria, systemic reaction (discomfort, nausea, ho hlohlona) ho fihlela nts'etsopele ea anaphylactic,
• Boitšoaro ba lehae: hyperemia, ho teneha, ho ruruha,
• ba bang: tabeng ea ts'ebetso ea lithethefatsi ka potlako - ho hema ka thata, khatello e matla ea maqhubu (ho utloahala ho imeloa ke hlooho)

Matlapa a koahetsoeng

Matlapa a lokela ho nooa ka molomo ka mpeng e se nang letho: metha ka botlalo 'me u noe metsi a mangata.

Nako ea kalafo, ho latela boteng ba lefu lena, ke matsatsi a 30-60.

Haeba ho hlokahala, makhetlo a 2-3 ka selemo, o ka tsamaisa lithuto tse phetoang.

Litlamorao

Tharollo 'me u tsepamise maikutlo

• ho tloha tsamaisong ea endocrine: ho fokotseha ha khatello ea tsoekere maling maling (litšitiso tse bonoang, ho fufuleloa ho feteletseng, ho tsekela, hlooho ea hlooho),
• lehlakoreng la tsamaiso ea methapo e kholo: ho tlola kapa ho fetola tatso, ho tsitsipana, ho tsietsana ha sethoathoa,
• Ho tsoa ho sheropoietic system: hemorrhagic rash (purpura), thrombocytopenia, thrombophlebitis, hempoint hemorrhages letlalong le mucous membrane,
• letlalong la letlalo le linama tse tšetseng lintho tse ling: eczema, ho hlohlona, ​​lekhopho,
• lehlakoreng la sebono sa pono: diplopia,
• karabelo: "urticaria, systemic reaction (discomfort, nausea, ho hlohlona) ho fihlela nts'etsopele ea anaphylactic,
• Boitšoaro ba lehae: hyperemia, ho teneha, ho ruruha,
• ba bang: tabeng ea ts'ebetso ea lithethefatsi ka potlako - ho hema ka thata, khatello e matla ea maqhubu (ho utloahala ho imeloa ke hlooho)

Matlapa a koahetsoeng

Ka tloaelo Thiogamma e mamelloa hantle. Khafetsa, ho kenyelletsa le maemong a le mong, ho ba le litla-morao tse latelang:

• karabelo: - urticaria, lekhopho la letlalo, ho hlohlona, ​​tsamaiso ea methapo ho fihlela nts'etsopele ea anaphylactic,
• Ho tsoa ho lijo tsa ka mpeng: bohloko ba ka mpeng, ho nyekeloa ke pelo, lets'ollo, ho hlatsa,
• ho tloha tsamaisong ea endocrine: ho fokotseha ha tsoekere ea mali maling (litšitiso tse bonoang, ho fufuleloa ho eketsehileng, ho tsekela, hlooho ea hlooho).

Ho sebelisana le lithethefatsi

• ethanol le metabolites ea eona: phello ea thioctic acid e fokola,
• cisplatin: ts'ebetso ea eona ea fokotseha
• glucocorticosteroids: lithibelo tsa bona tse khahlanong le ts'oaetso li matlafatsoa,
• insulin, litlhare tsa hypoglycemic tsa molomo: litlamorao tsa tsona lia ntlafatsoa.

Thioctic acid e tlama tšepe (tšepe, magnesium), ka hona, haeba ho hlokahala, ts'ebeliso e tšoanang ea litokisetso tse nang le tsona e lokela ho bonoa bonyane nako ea lihora tse 2 pakeng tsa tekanyetso.

Thioctic acid e kopana le limolek'hule tsa tsoekere, ho etsa mohlala, ka tharollo ea levulose (fructose), ka lebaka la eona ho thehiloe meetso e sa sebetseng hantle.

Ka mokhoa oa tharollo ea infusion, Thiogamm ha e lumellane le tharollo e arabelang ka lihlopha tsa disulfide le tsa SH, tharollo ea Ringer le tharollo ea dextrose.

Lithethefatsi tse latelang ke li-analogues tsa Thiogamma: Thioctacid BV, Lipoic acid, Tiolepta, Berlition 300, Thioctacid 600T.

Lipehelo le maemo a polokelo

Tsoela hole le bana, u sirelelitsoe ke khanya, ka mocheso o fihlang ho 25 ° C.

Bophelo ba Shelf ke lilemo tse 5.

Leqephe lena le fana ka lethathamo la li-analogues tsohle tsa Tiogamm ka sebopeho le letšoao bakeng sa tšebeliso. Lethathamo la li-analogues tse theko e tlaase, hape u ka bapisa litheko libakeng tsa meriana.

• Analogue e theko e tlaase ka ho fetisisa ea Tiogamm:
• Analogue e tummeng ka ho fetisisa ea Tiogamma:
• Sehlopha sa ATX: Thioctic asiti
• Motsoako o sebetsang: thioctic asiti

Li-analoggs ka pontšo le mokhoa oa ts'ebeliso

Moetso o fapaneng o kanna oa lumellana ho bonts'a mokhoa le mokhoa oa ts'ebeliso

Ho etsa lethathamo la litheko tse theko e tlaase tsa lithethefatsi tse theko e boima, re sebelisa litheko tse re fang li-pharmacy tse fetang 10,000 ho pholletsa le Russia. Sebaka sa polokelo ea lithethefatsi le litlhaloso tsa bona li lula li ntlafatsoa letsatsi le leng le le leng, kahoo tlhaiso-leseling e fanoeng webosaeteng ea rona e lula e le teng ho tloha kajeno. Haeba ha u fumane analogue ea khahleho ho uena, ka kopo sebelisa patlo e kaholimo 'me u ikhethele moriana o khahlisang lethathamong leo. Leqepheng la e 'ngoe le e' ngoe ea bona u tla fumana likhetho tsohle tse fumanehang bakeng sa mofuta oa moriana oo u o batlang, hammoho le litheko le liaterese tsa lik'hemisi tseo e fumanehang ho tsona.

Thupelo ea Tiogamma

TLOTLISO
ka tšebeliso ea lithethefatsi
Tiogamma

Ketso ea pharmacological
Ntho e sebetsang ea Thiogamma (Thiogamm-Turbo) ke acid e bitsoang thioctic (alpha-lipoic). Thioctic acid e thehoa 'meleng' me e sebetsa e le coenzyme bakeng sa metabolism ea matla a alpha-keto acid ka oxidative decarboxylation. Thioctic acid e lebisa ho fokotseha ha tsoekere e ngata serumeng ea mali, e thusa ho bokella glycogen ho hepatocytes. Mathata a Metabolic kapa ho haella ha thioctic acid ho bonoa ka ho bokellana ho feteletseng ha metabolites e itseng 'meleng (mohlala,' mele oa ketone), hammoho le ts'ebeliso ea tahi. Sena se lebisa ho tsitsinyehong ho ketane ea aerobic glycolysis. Thioctic acid e teng 'meleng ka sebopeho sa mefuta e' meli: e fokotsehile ebile e na le oxidized. Mefuta eo ka bobeli e sebetsa 'meleng, e fana ka litlamorao tsa antioxidant le anti-toxic.
Thioctic acid e laola metabolism ea lik'habohaedreite le mafura, e ama hantle metabolism ea cholesterol, e na le phello ea hepatoprotective, e ntlafatsa ts'ebetso ea sebete. Tšusumetso e ntle lits'ebetsong tse iphetisang ho tishu le litho. Melemo ea pharmacological ea thioctic acid e ts'oana le litlamorao tsa livithamini tsa B. Nakong ea karolo ea pele ka sebete, acid ea thioctic e fetoha le liphetoho tse kholo. Ka mokhoa oa ho fumaneha hoa lithethefatsi, ho fokotseha hoa bohlokoa hoa motho ka mong hoa hlokomeleha.
Ha e sebelisoa kahare, e potlakile ebile e batla e amohuoa ka botlalo ho tsoa mohloling oa tšilo ea lijo. Metabolism e tsoela pele le oxidation ea lehlakore la lehlakore la thioctic acid le conjugation ea eona. Nako ea ho felisoa ha halofo ea bophelo ba Tiogamma (Tiogamm-Turbo) e tsoa metsotso e 10 ho isa ho e 20. Ho felisoa ka moroto, ka metabolites ea thioctic acid e ka pele.

Matšoao a ho sebelisoa
Ka lefu la tsoekere la tsoekere ho ntlafatsa kutloisiso ea lisele.

Mokhoa oa kopo
Thiogamm-Turbo, Thiogamm bakeng sa tsamaiso ea batsoali
Thiogamm-Turbo (Thiogamma) e etselitsoe tsamaiso ea batsoali ka ho kenella ka hare ho marang-rang. Bakeng sa batho ba baholo, lethal dose ea 600 mg (litaba tsa 1 vial kapa 1 ampoule) e sebelisoa hang ka letsatsi. Ho kenella ho etsoa butle, bakeng sa metsotso e 20-30. Nako ea phekolo e nka libeke tse peli ho isa ho tse 'ne. Nakong e tlang, ho khothalletsoa ts'ebeliso ea kahare ea Tiogamma matlapeng. Tsamaiso ea botsoali ea Thiogamma-Turbo kapa Thiogamm bakeng sa infusion e laeloa bakeng sa mathata a matla a ho utloa bohloko a amanang le lefu la tsoekere.

Melao ea tsamaiso ea batsoali ea Thiogamma-Turbo (Thiogamm)
Likahare tsa botlolo e le 'ngoe ea Thiogamma-Turbo kapa 1 ampoule ea Thiogamma (600 mg ea lithethefatsi) li qhibilihile ka 50-250 ml ea tharollo ea chloride ea 0,9%. Tekanyo ea infravenous infusion - eseng ho feta 50 mg ea thioctic acid ka motsotso o le mong - sena se lekana le 1,7 ml ea tharollo ea Tiogamma-Turbo (Tiogamma). Litokisetso tse hlapolotsoeng li lokela ho sebelisoa hang ka mor'a ho kopanya le solvent. Nakong ea infusion, tharollo e lokela ho sireletsoa leseli ke thepa e khethehileng e sireletsang leseli.

Tiogamma
Matlapa a etselitsoe ho sebelisoa kahare. Ho khothalletsoa ho fana ka 600 mg ea moriana o 1 ka letsatsi. Letlapa le lokela ho metsoa le felle, ho sa natsoe lijo, le hlatsuoe ka metsi a lekaneng. Nako ea kalafo ea pilisi e tsoa ho likhoeli tse 1 ho isa ho tse 'ne.

Litlamorao
Tsamaiso ea methapo e bohareng: maemong a sa tloaelehang, hang hang ka mor'a tšebeliso ea lithethefatsi ka mokhoa oa ho kenella, ho ka khoneha hore ho be le meroalo e matla ea mesifa.
Litho tsa kutlo: tlolo ea maikutlo a tatso, diplopia.
Sisteme ea Hematopoietic: purpura (hemorrhagic rash), thrombophlebitis.
Boitšoaro ba Hypersensitivity: Boits'oaro bo hlophisehileng bo ka baka ho ts'oaroa ha anaphylactic, eczema kapa urticaria sebakeng sa ente.
Sistimi ea digestive (bakeng sa matlapa a Tiogamma): lipontšo tsa dyspeptic.
Ba bang: haeba Tiogamm-Turbo (kapa Tiogamm bakeng sa tsamaiso ea batsoali) e tsamaisoa ka potlako, khatello ea maikutlo le moea oa ho thatafala sebakeng sa hlooho li ka khonahala - lits'oants'o tsena li emisa kamora ho fokotseha ha sekhahla sa infusion. Hape ho khoneha: hypoglycemia, ho chesa ho chesang, ho tsekela, ho fufuleloa, pelo, ho fokotseha tsoekere ea mali, ho nyekeloa, pono e ferekanyang, hlooho e bohloko, ho hlatsa, tachycardia.

Contraindication
Maemo a mamello a qholotsa nts'etsopele ea lactic acidosis (bakeng sa Thiogamma-Turbo kapa Thiogamm bakeng sa tsamaiso ea batsoali),
lilemo tsa bana
ho ima le ho nyekeloa
allergic reaction in thioctic acid kapa likarolo tse ling tsa Thiogamm (Thiogamma-Turbo),
a tebileng a hepatic kapa a renal
maemo a hlobaetsang a infarction ea myocardial,
mokhoa o ntlafalitsoeng oa ho hloleha ho phefumoloha kapa oa pelo,
ho omella
joala bo sa foleng,
kotsi ea methapo ea pelo.

Boimana
Nakong ea bokhachane kapa nakong ea kanyeso, tšebeliso ea Thiogamma le Thiogamm-Turbo ha e khothalletsoe, kaha ha ho na boiphihlelo bo lekaneng ba kliniki ka meriana e fanoang.

Ho sebelisana le lithethefatsi
Ho sebetsa ha lithethefatsi tsa hypoglycemic le insulin ho eketsoa hammoho le Thiogamma (Thiogamma-Turbo). Tharollo ea Thiogamma-Turbo kapa Thiogamm ha e lumellane le solvent e nang le limolek'hule tsa glucose, hobane thioctic acid e baka metsoako e rarahaneng ea tsoekere. Litekong tsa vitro, asiti ea thioctic e ile ea sebetsana le li-ion complexes tsa tšepe. Mohlala, motsoako o nang le cosplantine, magnesium le tšepe o ka fokotsa phello ea morao ha e kopantsoe le thioctic acid. Li-solvents tse nang le lintho tse kopanang le li-compact tsa disulfide kapa lihlopha tsa SH ha li sebelisoe ho hlapolla tharollo ea Thiogamma-Turbo (Thiogamma) (mohlala, tharollo ea Ringer).

Bongata
Ka overdose ea Tiogamma (Tiogamm-Turbo), hlooho e bohloko, ho hlatsa le ho nyekeloa hoa pelo ho khonahala. Phekolo ke letšoao.

Fomu ea tokollo
Tiogamm Turbo
Tharollo ea infusion ea botsoali ho li-vials tse 50 (1,2% thioctic acid). Ka sephutheloaneng - 1, libotlolo tse 10.Ho kenyelelitsoe linyeoe tse khethehileng tsa lebone la motlakase.

Matlapa a Tiogamma
Matlapa a koahetsoeng ka 600 mg bakeng sa tšebeliso ea kahare. Ka paketeng ea matlapa a 30, 60.

Tharollo ea Thiogamma ea infusion
Tharollo ea tsamaiso ea botsoali ka li-ampoules tsa 20 ml (3% thioctic acid). Ka paketeng - li-ampoules tse 5.

Maemo a polokelo
Sebakeng se sirelelitsoeng leseli, ka mocheso oa likhato tse 15 ho isa ho tse 30 tsa Celsius. Tharollo e lokiselitsoeng ho kenella kahare ha e na poloko. Ampoules le lipompo li lokela ho ba liphuthehong tsa pele feela.

Sebopeho
Tiogamm Turbo
Lintho tse sebetsang (ka 50 ml): thioctic acid 600 mg.

50 ml ea tharollo ea tlhahiso ea "Tiogamma-Turbo" e na le meglumine ea alpha-lipoic acid ka tekanyo ea 1167.7 mg, e lumellanang le 600 mg ea thioctic acid.
Tiogamma
Lintho tse sebetsang (ka har'a letlapa le le leng): thioctic acid 600 mg.
Lintho tse ling: colloidal silicon dioxide, cellcose ea microcrystalline, talc, lactose, methylhydroxypropyl cellulose.
Tiogamma
Lintho tse sebetsang (ka 20 ml): thioctic acid 600 mg.
Lintho tse ling: metsi a ente, macrogol 300.
20ml ea tharollo ea inflants ea Tiogamma e na le meglumine letsoai la alpha-lipoic acid ka bongata ba 1167.7 mg, e lumellanang le 600 mg ea thioctic acid.

Sehlopha sa mahlale
Lihormone, li-analogues tsa bona le lithethefatsi tsa antihormonal
Lithethefatsi tse thehiloeng ho li-pancreatic le lithethefatsi tse entsoeng ka hypoglycemic
Synthetic hypoglycemic agents

Ntho e sebetsang : Thioctic asiti

Boikhethelo
Ka botlolong e nang le Thiogamm-Turbo e qhibilihang, roala linyeoe tse khethehileng tse sireletsang lebokoseng le leng. Tharollo ea Thiogamm e sirelelitsoe ka lisebelisoa tse sireletsang. Phekolo ea bakuli, litekanyetso tsa tsoekere ea serum li lokela ho lekanngoa khafetsa, ho latela hore na litekanyetso tsa li-insulin le lithethefatsi tsa hypoglycemic li lokela ho fetoloa ho qoba hypoglycemia. Ts'ebetso ea kalafo ea thioctic acid e fokotsehile haholo ka tšebeliso ea joala (ethanol). Ha ho na litemoso tse ling tsa bohlokoa.

Tlhahisoleseling eohle e hlahisoa molemong oa tlhahisoleseling mme ha se lebaka la ho itlhalosa kapa ho fetola moriana.

Litšoantšiso tsa thiogamm ea lithethefatsi li hlahisoa, ho latela polelo ea bongaka e bitsoang "li-syonyms" - lithethefatsi tse fetohang tse nang le ntho e le 'ngoe kapa tse ngata tse tšoanang ka litlamorao tsa tsona' meleng. Ha u khetha li-synonyms, u se ke ua nahana feela ka litšenyehelo tsa bona, empa hape le naha ea tlhahiso le botumo ba moetsi.

Ketso ea pharmacological

Sesebelisoa se ka sehloohong sa ho hlophisoa ha litlhare Tiogamm, ho sa tsotelehe mofuta oa tokollo, ke thioctickapa alpha lipoic acid (mabitso a mabeli a ntho e tšoanang e sebetsang). Ena ke karolo ea tlhaho ea metabolism, ke hore, ka tloaelo acid ena e thehiloe 'meleng ebe e sebetsa joalo ka coenzyme ea mechini ea metochondrial metabolism ea matla a phervic acid le alpha-keto acid tseleng ea oxarative decarboxylation. Thioctic acid hape e endo native, hobane e khona ho tlama li-radicals tsa mahala le ho sireletsa lisele ho litlamorao tsa tsona tse senyehileng ka tsela ena.

Karolo ea karolo ea motsoako le eona e bohlokoa carbohydrate metabolism. E thusa ho fokotsa tsoekere e potoloha ka bolokolohi setsong sa mali le ho bokellana ha glycogen liseleng tsa sebete. Ka lebaka la thepa ena, thioctic acid e fokotsa lisele, ka mantsoe a mang, karabelo ea 'mele ea hore na lihormone ena e sebetsa hakae.

E kenelletse tsamaiso ea lipid metabolism. Kameho ea ntho e sebetsang ho metabolism e le moemeli oa hypocholesterolemic e bonahala haholo - asiti e fokotsa ho potoloha ha lipids tse tlase haholo le tse tlase haholo le liperesente tsa lipid tse phahameng tsa kutlo tsa li-serum tsa mali li eketseha. Ka mantsoe a mang, acid ea thioctic e na le mofuta o itseng thepa ea antiatherogenic 'me e hloekisa bethe e fokolang ea micro- le macrocirculatory ea mafura a mangata.

Liphello tsa tlhabollo Litokisetso tsa meriana le tsona lia bonahala maemong a chefo ka letsoai le leholo la tšepe le mefuta e meng. Ketso ena e hlaha ka lebaka la ts'ebetso ea ts'ebetso ea ts'ebetso ho sebete, ka lebaka la eona ts'ebetso ea eona e ntlafala. Leha ho le joalo, acid ea thioctic ha e kenye letsoho ho feliseng mehloli ea eona ea 'mele, esita le ka mokhoa o fapaneng e na le matla hepatoprotective mali.

Ho lokela ho hopoloa hore lithethefatsi tse thehiloeng ho alpha-lipoic acid li sebelisoa ka mafolofolo, hobane likarolo li thusa ho theha sebopeho sa li-metabolites tsa glycation tsa ho qetela mme li eketsa sethaleng ho boleng bo tloaelehileng ba 'mele. Hape mesifa ea trophic ea ntlafala le phallo ea mali ea endoneural, e lebisang keketseho e akaretsang ea boemo ba methapo ea methapo ea kutlo le ho thibela nts'etsopele ea lefu la tsoekere (karolo ea nosological e hlahang ka lebaka la tšenyo ea likholomo tsa methapo ka bongata ba glucose le metabolites ea eona.

Maemong a eona a meriana (hepato- le neuroprotective, detoxification, antioxidant, hypoglycemic le ba bang ba bangata) acid ea thioctic e ts'oana livithaminiSehlopha sa B.

Thioctic kapa alpha lipoic acid e tumme hohle ho cosmetologyka lebaka la ketso e latelang ea pharmacology ho letlalo la sefahleho, eo hangata ho leng thata ho e hlokomela:

• ea tloha hypersensitivity,
• ho tiisa mesifa ea letlalo e fokotsa botebo ba wrinkleho etsa hore li se ke tsa bonahala esita le libakeng tse thata tse kang likhutlo tsa mahlo le molomo.
• o folisa likotsi tsa (makhopho) le maqeba, hobane, e kenella ka har'a ntho e kopaneng, e tsosa ts'ebetso e tloaelehileng ea ts'ebetso ea liphetoho tse ling,
• e tiisa li-pores sefahlehong mme e laola bokhoni ba ts'ebetso sebeteous litsoelesaka ho etsa joalo imolla mathata a letlalo le mafura kapa le mafura,
• e sebetsa joalo ka antioxidant e matla ea tlhaho ea tlhaho.

Thiogamma, litaelo tsa tšebeliso (Mokhoa le litekanyetso)

Litaelo tsa ho sebelisa Thiogamma li fapana haholo ho latela sebopeho sa meriana se sebelisitsoeng.

Matlapa a 600 mg sebelisoa ka molomo hang ka letsatsi. Se ke oa li hlafuna, hobane khetla e kanna ea senyeha, ho kgothaletsoa ho e nooa ka metsi a fokolang. Nako ea thupelo e beoa ka kotloloho ke ngaka e eang teng, hobane ho latela tekanyo ea lefu lena. Ka tloaelo matlapa a nooa ho tloha matsatsing a 30 ho isa ho a 60. Ho pheta-pheta tsela ea phekolo e matlafatsang ho khoneha makhetlo a 2-3 ka selemo.

Tiogamm Turbo e sebelisoang bakeng sa tsamaiso ea batsoali ka ho kenella ka hare ho marang-rang. Litekanyetso tsa letsatsi le letsatsi ke 600 mg 1 nako e le ngoe ka letsatsi - e baliloe likateng tsa botlolo e le 'ngoe. Selelekela e etsoa butle, ka nako e fetang metsotso e 20-30, e le ho qoba litla-morao ho tsoa ho ts'ebetso ea litlhare kapele. Nako ea kalafo ea mofuta ona oa lithethefatsi e tsoa ho libeke tse peli ho isa ho tse 'ne (nako e khuts'oane ea kalafo e potlakileng e bakoa ke ho tsepamisoa ho hoholo hoa plasma kamora ho tsamaisoa ha bongaka ba moriana).

Tsepamisa mohopolo bakeng sa ho hlophisoa ha infravenous infusions e sebelisoang ka tsela e latelang: se ka hare ho ampoule e le 1 (ho latela motsoako o ka sehloohong o sebetsang - 600 mg ea thioctic acid) e kopantsoe le 50-250 isotonic (liperesente tse 0.9) tharollo ea sodium chloride. Hang ka mor'a ho hlophisoa ha motsoako oa kalafo, botlolo e koaheloa ka nyeoe e sireletsang (ntle le ho senya, ho na le nyeoe e le 'ngoe ka sephutheloana sa moriana ka har'a sephutheloana sa lithethefatsi). Hang-hang tharollo e fanoa ke ho kenella ka nako e fetang metsotso e 20-30. Nako e phahameng ea ho boloka tharollo ea Tiogamm e lokisitsoeng ha e fetise lihora tse 6.

Thiogamma e ka sebelisoa bakeng sa tlhokomelo ea letlalo la sefahleho. Ho etsa sena, etsa kopo mokhoa oa litlhare bakeng sa litlolo tse tsamaeang ka har'a li-vials (li-ampoules tse nang le mohopolo o matla bakeng sa ho hlophisoa ha infusions ea methapo ha li tšoanelehe joalo ka sehlahisoa sa litlolo, kaha li ka baka karabelo ka lebaka la bongata bo boholo ba karolo e sebetsang). Likarolo tsa botlolo e le 'ngoe li kenngoa ka mokhoa o hloekileng holim'a letlalo lohle habeli ka letsatsi - hoseng le ka shoalane. Pele ho thetso e joalo, ho kgothaletsoa ho hlatsoa ka metsi a futhumetseng a nang le sesepa e le hore a hloekise heke ea lipores bakeng sa ho kenella ka mokhoa o tebileng oa thioctic acid.

Li-Analogs tsa Thiogamm

Lits'oants'o tsa khoutu ea 4 ea ATX:

Li-analog tsa Thiogma li theha sehlopha se seholo sa meriana, hobane litlamorao tse fanoang ke kalafo li se li hlokahala haholo. Ho bonolo haholo ho sebelisa lithethefatsi bakeng sa thibelo ea li-neuropathies tse matla ho fapana le ho li phekola hamorao ka mokhoa oa ho boloka kalafo, ho ea thupelong e telele le e khathatsang ea kalafo ea lithethefatsi. Kahoo ho sebelisoa Tiogammar:

Tiogamma: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Thiogamma

Khoutu ea ATX: A16AX01

Motsoako o sebetsang: Thioctic acid (Thioctic acid)

Moetsi: Verwag Pharma GmbH & Co KG (Worwag Pharma GmbH & Co KG), Beblingen, Jeremane

Nchafatso ea litlhaloso le foto: 05/02/2018

Thiogammama ke lithethefatsi tse laolang metabolism ea lipid le carbohydrate.