Espa Lipon (600 mg

Ho latela litaelo tsa Espa-Lipon, lithethefatsi li na le detoxification, hypoglycemic, hypocholesterolemic le hepatoprotective, li nka karolo mo taolong ea metabolism. Thioctic acid, eo e leng karolo ea Espa-Lipon, e ameha liphatlalatsong tse nang le oxidative tsa alpha-keto acid le pyruvic acid, e ntlafatsa ts'ebetso ea sebete, hape e matlafatsa metabolism ea cholesterol.

Ka mofuta oa ketso, thioctic acid e tšoana le livithamini tsa B. Espa-Lipon e phahamisa keketseho ea glycogen liseleng tsa sebete, ho fokotseha ha khatello ea "glucose" maling, le ho hlola tlolo ea ts'enyo ea sele ea insulin. Setlhare sena se thusa ho tlosa chefo 'meleng, e sireletsa lisele tsa sebete ho pepesehela lintho tse chefo, e sireletsa' mele ha o ka chefo ka letsoai la tšepe e boima.

Kameho ea neuroprotective ea Espa-Lipon ke ho thibela lipid peroxidation liseleng tsa methapo, ho kenya phallo ea mali a endoneural, le ho tsamaisa ts'ebetso ea ho tsamaisa litakatso tsa methapo ka lisele.

Ho nka lithethefatsi ho bakuli ba nang le motor neuropathy, ho latela litlhahlobo tsa Espa-Lipon, ho qholotsa ponahalo ea likhakanyo tse ngata tsa macroergic mesifa.

Ha ho nooa ka molomo, Espa-Lipon e hantle ebile e kenella ka potlako tšelong ea lijo, 'me tšebeliso ea lithethefatsi ka nako e tšoanang e fokotsa lebelo le boleng ba ho amoheloa ha moriana.

Metabolization ea thioctic acid e etsoa ka conjugation le oxidation ea liketane tse lehlakoreng. Ntho e sebetsang Espa-Lipon e pepesitsoe ka har'a moroto ka mokhoa oa metabolites. Bophelo ba halofo ea lithethefatsi tse tsoang lero la mali ke metsotso e 10-20.

Espa-Lipon e na le "phello ea pele" ka har'a sebete - ka mantsoe a mang, litheko tse sebetsang tsa moriana li fokotsoe ka tlase ho tšusumetso ea mosireletsi oa tlhaho ea tsoang linthong tse kantle tse kenang 'meleng.

Foromo ea litekanyetso

Nahanela tharollo ea infusion 600 mg / 24 ml

24 ml le 1 ml ea moriana o na le

ntho e sebetsang: thioctic acid ho 24 ml-600.0 mg le 1 ml-25.0 mg

kamothusise dinthoa: ethylenediamine, metsi bakeng sa ente.

Transparent mokelikeli ho tloha mosehla o mosehla ho ea mosehla o moputsoa.

Melemo ea pharmacological

Mofumahali

Suction. Ka tsamaiso ea methapo, nako ea ho fihla boholo ba mahloriso a plasma ke metsotso e 10-11, khatello e phahameng ke 25-38 isg / ml, sebaka se ka tlas'a nako ea khefutso ke nako ea 5 μg h / ml. Bioavailability ke 100%.

Metabolism: Thioctic acid e kenella ka har'a "sebete" sa pele.

Tsamaiso: bophahamo ba karolelano ea chelete e ka ba 450 ml / kg.

Ho tlohela: thioctic acid le metabolites ea eona li hlahisoa ke liphio (80-90%). Ho felisoa ha halofo ea bophelo ke metsotso e 20-50. Tlhahiso ea plasma ka kakaretso ke metsotso e 10-15.

Pharadodynamics

Espa-lipon - antioxidant ea endo native (e kopanyang li-radicals tsa mahala), e thehoa 'meleng ka oxidative decarboxylation ea alpha-keto acid. Ha e le coenzyme ea mitochondrial multenzyme complexes, e nka karolo ho oxidative decarboxylation ea pyruvic acid le alpha-keto acid. E thusa ho fokotsa khatello ea "glucose" maling le ho eketsa glycogen sebete, hammoho le ho hlola insulin. Ka mofuta oa ts'ebetso ea biochemical, e haufi le livithamini tsa B. E nka karolo taolong ea methapo ea lipid le carbohydrate, e matlafatsa metabolism ea cholesterol, e ntlafatsa ts'ebetso ea sebete, e fokotsa phello e senyang ea chefo ea emong le e tsoang ho eona. E ntlafatsa li-neurons tsa trophic.

Pharadodynamics

Thioctic asiti — antioxidant, e thehiloeng 'meleng ka li-decarboxylation tsa alpha-keto acid. E na le phello e tšoanang le Li-vithamine tsa B. E bapala karolo ea metabolism ea matla, e laola lipid (cholesterol metabolism) le metabolism ea carbohydrate. Morekisi lipotropicle phetisetso. Tšusumetso ho metabolism ea carbohydrate e baka keketseho glycogenka har'a sebete le ho fokotseha tsoekeremading.

E ntlafatsa trophism ea li-neuron, kaha e bokellana ho tsona le ho fokotsa litaba tsa radicals tsa mahala le ts'ebetso ea sebete (ka mokhoa oa kalafo).

Morekisi lipid-lowing, hypoglycemic, hepatoprotectivele hypocholesterolemic athari.

Tekanyetso le tsamaiso

Qalong ea kalafo, moriana o fanoa ka mokhoa oa botsoali. Hamorao, ha ba etsa kalafo ea tlhokomelo, ba fetohela ho moriana kahare.

Nahanela tharollo ea infusion:

Setlhare se fanoa kahare ka tsela ea infusions kamora ho ts'oaroa pele ho tlotsoa ka 200-250 ml ea tharollo ea isotonic sodium chloride.

Ho mefuta e matla ea lefu la tsoekere la polyneuropathy moriana o fanoa hang ka letsatsi ka ho kenella ka lerotholi la 24 ml ea moriana ka tharollo ea isotonic sodium chloride (e lumellanang le 600 mg ea thioctic acid ka letsatsi). Nako ea infusion ke metsotso e 30. Nako ea phekolo ea infusion ke matsatsi a 5-28.

Litharollo tsa infusion tse lokiselitsoeng esale pele li lokela ho bolokoa sebakeng se lefifi mme li sebelisoe nakong ea lihora tse 6 kamora ho itokisa. Nakong ea infusion o lokela ho thatela botlolo ka pampiri e lefifi. E latelang, o lokela ho chencha kalafo ea tlhokomelo ka mokhoa oa matlapa ka tekanyetso ea 400-600 mg ka letsatsi. Nako e fokolang ea phekolo matlapeng ke likhoeli tse 3.

Maemong a mang, ho sebelisa moriana ho kenyelletsa tšebeliso e telele, nako eo ho tla khethoa ka eona ke ngaka e eang.

Litlamorao

- rashes letlalong, urticaria, ho hlohlona

- systemic allergic reaction (anaphylactic shock)

ho nyekeloa ke pelo, ho hlatsa, ho fetola tatso

-Kopa hemorrhage, tloaelo ea ho tsoa mali

ho se sebetse ka liplatelete

-Khetha tekanyo ea tsoekere (ka lebaka la phetisetso e ntlafalitsoeng ea tsoekere), e kanna ea tsamaea le ho tsekela, ho nyefoloa hoa pono tse fapaneng, ho eketseha ha mofufutso

- hlooho e opang (e fetang ka mokhoa o ikemetseng), khatello e eketsehileng ea methapo, khatello ea maikutlo (ka mor'a tsamaiso e potlakileng ea methapo)

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea Espa-Lipon e nang le insulin le li-antidiabetesic tsa molomo, phello ea hypoglycemic ea ho qetela e ea matlafatsoa.

Thioctic acid e etsa mofuta o thata oa qhibilihang ka limolek'hule tsa tsoekere (mohlala, tharollo ea levulose).

Tharollo ea infusion ha e lumellane le tharollo ea glucose, tharollo ea Ringer, hammoho le tharollo e ka sebelisanang le lihlopha tsa SH-kapa li-marangrang.

Thioctic acid (e le tharollo ea infusion) e fokotsa phello ea cosplatin.

Tsamaiso e ts'oanang ea tšepe, magnesium, lihlahisoa tsa lebese tse nang le calcium ha e khothaletsoe (ho ja pele ho feta lihora tse 6-8 kamora taolo ea lithethefatsi).

Litaelo tse khethehileng

Ha u etsa kalafo ea Espa-Lipon ho bakuli ba nang le lefu la tsoekere, haholo-holo qalong ea kalafo, ho hlokahala hore ho be le tlhahlobo ea khatello ea tsoekere ea mali kamehla. Maemong a mang, ho fokotsa tekanyetso ea li-agents tsa hypoglycemic hoa hlokahala.

Nakong ea kalafo, hoa hlokahala ho hana ka tieo ho noa joala, hobane phello ea kalafo ea thioctic acid e fokola.

Tharollo ea infusion e fanoa ka methapo, e leng hara libeke tse 22 karolong ea pele ea kalafo.

Bakeng sa tsamaiso ea methapo, likarolo tsa ampoule ea Espa-Lipon 600 mg li hlapolotsoe ka 250 ml ea tharollo ea sodium chloride ea 0,9%, ka mokhoa o kenyelletsang nako e khutšoane bonyane metsotso e 30.

Ka lebaka la phello e phahameng ea ntho e sebetsang, tharollo ea infusion e lokela ho lokisoa kapele pele ho tsamaiso, li-ampoules li lokela ho tlosoa ho tloha hang hang pele li sebelisoa, botlolo e lokela ho apesoa ka pampiri e lefifi nakong ea infusion. Bophelo ba sehatsetsing tharollo e lokiselitsoeng ho sebelisoa kamora ho hlapisoa ka tharollo ea isotonic sodium chloride ke boholo ba lihora tse 6 ha bo bolokiloe sebakeng se lefifi.

Bokhachane le pelehi

Ka lebaka la boiphihlelo bo sa lekaneng ba tšebeliso ea lithethefatsi, Espa-Lipon ha e fuoe basali ba baimana.

Ha ho kgothaletswe ho sebelisa moriana nakong ea lebone, hobane ha ho na tlhahiso-leseling ka monyetla oa ho pepeseha ha moriana ka lebese la matsoele.

Tšusumetso ho bokhoni ba ho khanna koloi kapa mochine o ka bang kotsi

Ka lebaka la litla-morao tse ka bang teng (lits'oaetso, diplopia, ho tsekela), tlhokomelo e lokela ho nkuoa ha o khanna koloi kapa o sebetsa ka mochini o tsamaisang.

Bongata

Matšoao ho opeloa ke hlooho, ho nyekeloa ke pelo, ho hlatsa.

Ho fetella ho ka baka lipontšo tsa kliniki ea ho tahoa ho matla le liphetoho tsamaisong ea methapo ea methapo (psychomotor furu le maikutlo a ferekanyang), lactic acidosis, hypoglycemia, le nts'etsopele ea DIC.

Phekolo: matšoao kalafo, haeba ho hlokahala - kalafo anticonvulsant, mehato ea ho boloka mesebetsi ea litho tsa bohlokoa. Ha ho na litlhare tse tobileng.

Setifikeiti sa ho ingolisa

Esparma GmbH, Seepark 7, 39116 Magdeburg, Jeremane

Aterese ea mokhatlo e amohelang likopo ho tsoa ho bareki ka boleng ba lihlahisoa Rephaboliking ea Kazakhstan

Ofisi ea moemeli oa Pharma Garant GmbH

Zhibek Zholy 64, theoha.305 Almaty, Kazakhstan, 050002

Matšoao a sebelisang Espa-Lipona

Ho latela litaelo, Espa-Lipon e fuoe maemo a latelang a bakuli.

• Polyneuropathies (ho kenyeletsoa le lefu la tsoekere le lino tse tahang),
• Maloetse a sebete (ho kenyeletsa le lefu la ho hlohlona kapa lefu la ho ruruha le sa foleng),
• Ho tahoa ho sa feleng kapa ho kula ho amanang le chefo ka letsoai la tšepe tse ngata, li-mushroom, jj.

Hape, lithethefatsi li sebetsa hantle khahlanong le lefu la atherosclerosis, le sebelisetsoang kalafo le thibelo ea lefu la arterial.

Contraindication

Espa-Lipon ha e fuoe bakuli ba nang le bothata ba ho lemalla joala bo sa foleng, lefu la tsoekere la glucose-galactose, hammoho le batho ba nang le khaello ea 'mele' meleng.

Ka hloko, ts'ebeliso ea Espa-Lipon e khothalletsoa ho bakuli ba nang le lefu la tsoekere - ka phetoho e tlamang ea lethal dose ea li-hypoglycemic agents. Bana ha baa lokela ho feta kalafong ea Espa-Lipon bakeng sa bana ba ka tlase ho lilemo tse 18 - ka lebaka la khaello ea ya data mabapi le polokeho ea ho sebelisa lithethefatsi bakeng sa sehlopha sena sa bakuli. Haeba ho na le matšoao a bohlokoa, moriana o ka nkuoa ke batho ba lilemo tsena ho latela tumello ea ngaka, ho latela tekanyetso ea motho ka mong.

Tšireletseho e felletseng ea Espa-Lipon bakeng sa bophelo bo botle ba masea ha a sebelisa moriana nakong ea kemolo le eona ha e so netefatsoe. Haeba ho hlokahala ho phekola mosali ea nang le Espa-Lipon nakong ea lebollo, ho hlokahala hore ho rarolloe bothata ba ho khoesoa ha ngoana ka nakoana matsoeleng.

Ho sebelisana le lithethefatsi

Tsamaiso e ts'oanang ea Espa-Lipon ka lithethefatsi tsa hypoglycemic ea molomo le insulin e ka baka keketseho ea phello ea hypoglycemic - keketseho ea kutloelo-bohloko ea litho tse ka hare tsa 'mele ho ea insulin.

Ts'ebeliso ea Espa-Lipon ho latela litaelo hammoho le joala ba ethyl e fokotsa ts'ebetso ea thioctic acid. Nakong ea phekolo le moriana, ho khothalletsoa ho hana ho nka lihlahisoa tse nang le ethanol le lino tse tahang.

Ntle le moo, ts'ebetso ea thioctic acid mabapi le tlamo ea tšepe e fumanoe, ka hona, ts'ebeliso ea Espa-Lipon ka nako e ts'oanang le lithethefatsi tse nang le tšepe, calcium, ion ea magnesium e ka khoneha ka karohano ea lihora tse peli pakeng tsa litekanyetso tsa lithethefatsi.

Ho nka Espa-Lipon ka chisplatin ho fokotsa katleho ea lithethefatsi.

Espa-Lipon, litaelo tsa tšebeliso (Mokhoa le litekanyetso)

Khafetsa, kalafo e qala ka li-infusions tsa iv, e lateloe ke ho chencha matlapa a Espa-Lipon. Matlapa a nooa ka molomo, ntle le ho hlafuna, metsotso e 30 pele ho lijo 1 nako e le ngoe ka letsatsi. Tekanyetso ea letsatsi le letsatsi ea 600 mg. Likhoeli tse 3 Joalokaha ho laetsoe ke ngaka, moriana o ka nooa nako e telele ho feta.

Ho lefu la tsoekere taolo e hlokahalang tsoekeremading. Nakong ea kalafo, tšebeliso ha e khethoe ea joalae bontshang phello ea moriana.

Tšebelisano

Keketseho ea phello ea hypoglycemic e lemohuoa ha e sebelisoa le insulin kapa lithethefatsi tsa molomo tsa hypoglycemic.

Ts'ebetso e fokotsehile Cisplatin tumellanong le thioctic asiti.

Ethanole nyenyefatsa phello ea moriana.

E ntlafatsa phello e khahlanong le ho ruruha GKS.

Ka hona, tlama tšepe litokisetso tsa tšepe e ke ke ea abeloa ka nako e le 'ngoe. Ho amoheloa ha lithethefatsi tsena ho tsamaisoa ka nako (lihora tse 2).

Tlhahlobo ea Espa Lipon

Ha ho na litlhahlobo tse ngata mabapi le ts'ebeliso ea moriana ona, hobane Espa-Lipon e ne e sa sebelisoe hangata joalo ka monotherapy. Hangata ho na le litlhahlobo mabapi le tšebeliso ea eona ho lefu la tsoekere la polyneuropathy. Bakuli ba hlokometse hore ho amoheloa ka nako e telele ho thusitse ho tlosa bohloko maotong le maotong, ho chesa maikutlo, "marang-rang", mesifa ea mesifa le ho khutlisa kutlo e lahlehileng.

Ho mafura a sebete sa lefu la tsoekere lithethefatsi li kentse letsoho ho secretion ea bile e tloaelehileng le ho tlosa matšoao a dyspeptic. Ntlafatso ea bakuli e netefalitsoe ke tlhahlobo (tloaelo ea ts'ebetso) transaminase) le mefuta e metle ea matšoao a ultrasound.

Ho na le bopaki ha Espa-Lipon e sebelisitsoe ka katleho ho phekolo e rarahaneng atherosulinosis.

Maemong ohle, kalafo e qalile ka ho lahleloa ka marapo (10-20 droppers) sepetlele, ebe bakuli ba nka mofuta oa lipilisi, ka linako tse ling tekanyetso ea letsatsi le letsatsi e ne e le 1800 mg (matlapa a 3).

Litla-morao tsa eona, ho nyekeloa le pelo le ho otla ha pelo li bonoa ha o sebelisa lipilisi le thrombophlebitis ka tsamaiso ea methapo.

Lebitso:

Espa-Lipon (tharollo ea ente) (Espa-Lipon)

1 ampoule ea Espa-Lipon 300 e na:
Ethylene bisatsan-letsoai la alpha lipoic acid (ho latela alpha lipoic acid) - 300 mg,
Lihlahisoa: metsi bakeng sa ente.

1 ampoule ea Espa-Lipon 600 e na:
Ethylene bisatsan-letsoai la alpha lipoic acid (ho latela alpha lipoic acid) - 600 mg,
Lihlahisoa: metsi bakeng sa ente.

Boimana

Hona joale, ha ho na data e tšepahalang mabapi le polokeho ea tšebeliso ea lithethefatsi Espa-Lipon nakong ea kemolo. Moriana o ka laeloa nakong ea kemaro ke ngaka e eang haeba phaello e lebelletsoeng ho mme e feta haholo likotsi tse ka bang teng ho lesea.
Haeba ho hlokahala ho sebelisa moriana nakong ea lebone, ho hlokahala hore o ikopanye le ngaka ea hau le ho etsa qeto ka tšitiso e ka bang teng ea ho anyesa.

Maemo a polokelo

Setlhare se khothalletsoa hore se bolokoe sebakeng se ommeng hole le khanya ea letsatsi ka ho toba mocheso oa likhato tse 15 ho isa ho 25 tsa Celsius. Alpha lipoic acid e na le khanya e phahameng, kahoo ampoule e lokela ho tlosoa lebokoseng hang-hang pele e sebelisoa.
Bophelo ba sefuba sa lithethefatsi ke lilemo tse 3.
Tharollo ea infusion e itokiselitseng e ka bolokoa sebakeng se lefifi nako e sa feteng lihora tse 6.