Mokhoa oa ho sebelisa lithethefatsi Glyclazide?

Foromo ea litekanyetso - matlapa: flat-cylindrical, e batlang e le bosoeu kapa e tšoeu, e nang le kotsi le bevel (10 e ngoe le e 'ngoe ka lipaketeng tse bloker, ka pakete ea likarete tse tharo kapa tse 6 le litaelo tsa ts'ebeliso ea Gliclazide).

Letlapa la 1

ntho e sebetsang: gliclazide - 80 mg,
likarolo tse thusang: starch 1500 (sengoathoana se nang le motsoako oa poone), sodium lauryl sulfate, lactose monohydrate, sodium ea magnesium, sodium ea lipalesa.

Pharadodynamics

Glyclazide - sulfonylurea e tsoang molokong oa bobeli, moemeli oa hypoglycemic.

Mokhoa oa ts'ebetso ea ts'ebetso ea lithethefatsi o bakoa ke bokhoni ba ho tsosa secretion ea pancreatic insulin, ho eketsa phello ea sephiri sa "insulin" le ho eketsa kutloisiso ea lithane ho insulin. Gliclazide e matlafatsa ts'ebetso ea li-enzymes tse kenang ka hare tse kang mesifa ea glycogen synthetase. Fokotsa nako ea ho qalella ho tloha motsotso oa ho ja ho isa ho qala ho secretion. Ho fapana le tse ling tse tsoang ho sulfonylurea, e khutlisetsa tlhoro ea pele ea insulin. E fokotsa hyperglycemia ea postprandial.

Gliclazide e sebetsa hantle mellitus ea metabolic le ea morao-rao, ho kenyelletsa le ho bakuli ba nang le botenya ba molao-motheo. Normalization ea boemo ba glycemic e lemohuoa matsatsi a 'maloa ka mor'a ho qala kalafo. Moriba o thibela nts'etsopele ea microvasculitis, ho kenyelletsa le tšenyo ea leihlo la mahlo. E hatella pokello ea liplatelete. Ho eketsa tšebetso ea fibrinolytic le heparin, hammoho le mamello ea heparin. Haholoholo e eketsa index ea ho se lumellane. E bonts'a ts'ebetso ea antioxidant, e ntlafatsa vascularization.

Ka lefu la tsoekere, "proteinuria" ea fokotsoa. Ka tšebeliso ea nako e telele, e thusa ho fokotsa proteinuria ho bakuli ba nang le lefu la tsoekere.

Kaha moriana o na le tšusumetso e kholo tlhorong ea pele ea insulin hape e sa bake hyperinsulinemia, ha e lebise keketseho ea boima ba 'mele. Ho feta moo, ho bakuli ba batenya haholo, gliclazide e thusa ho theola boima ba 'mele, ho latela lijo tse nang le khalori e tlase.

E na le ts'ebetso ea antiatherogenic, e fokotsa khatello ea cholesterol e felletseng maling.

Matla a antioxidant le hemovascular ea gliclazide a thusa ho fokotsa kotsi ea ho ba le mathata a vascular ho bakuli ba nang le lefu la tsoekere.

Mofumahali

Gliclazide e tšoauoa ka ho monya ho hoholo. Kamora tekanyetso ea molomo ea 40 mg, khatello e phahameng ka ho fetisisa (C_max) e tsebahala kamora lihora tse 2-3 'me e lekana le 2-3 μg / ml, kamora ho nka tekanyetso ea 80 mg, matšoao ana ke lihora tse 4 le 2.2-8 μg / ml, ka ho latellana.

Khokahano le liprotheine tsa plasma ke 85-97%, bophahamo ba pokello ke 0,35 l / kg. Khatello ea tekano e fihlelloa pele ho matsatsi a mabeli.

Gliclazide e tšelisoa ka har'a sebete ka ho theha li-metabolites tse 8. Palo ea metabolite ea mantlha ke 2-3% ea tekanyetso eohle e nkuoeng, ha e na thepa ea hypoglycemic, empa e ama microcirculation.

Half-life (T_½) - lihora tse 8-12. Setlhare se hlahisoa haholo ke liphio: 70% - ka sebopeho sa metabolites, eseng ho feta 1% - e sa fetoheng. Hoo e ka bang 12% ea gliclazide e epolloa ke mala ka moo e leng metabolites.

Litekanyetso tsa Pharmacokinetic maemong a mang:

ts'ebetso ea renal le ea sebete: maemong a hepatic le ho hloleha haholo ha renal, phetoho ho pharmacokinetics ea gliclazide e ka etsahala, likarolo tsa hypoglycemia ho bakuli ba joalo li ka ba telele, tse hlokang mehato e lekaneng,
botsofe: ha ho litšobotsi tsa pharmacokinetic tse ileng tsa bonoa.

Contraindication

mofuta oa 1 lefu la tsoekere (ho kenyeletsa le mofuta oa bacha oa MODI),
diabetesic hyperosmolar precoma le komello,
lefu la tsoekere ketoacidosis,
hypo- le hyperthyroidism,
ho ruruha haholo le / kapa ho hloleha ha sebete,
likotsi tse mpe le ho chesa,
mamello ea galactose, khaello ea lactase, malabsorption ea glucose-galactose,
lilemo tse 18
ho ima le ho nyekeloa
Tšebeliso e tšoanang ea miconazole,
hypersensitivity ho motsoako o mong le o mong oa lithethefatsi, sulfonamides kapa lithethefatsi tse ling tsa sehlopha sa sulfonylurea.

Ha ho khothalletsoe ho sebelisa Gliclazide hammoho le danazol, phenylbutazone, ethanol.

Gliclazide, litaelo tsa tšebeliso: mokhoa le litekanyetso

Matlapa a Glyclazide a lokela ho nooa ka molomo le lijo.

Qalong ea kalafo, 80 mg (1 letlapa) hangata e beoa nako e le 'ngoe ka letsatsi. Nakong e tlang, ngaka e khetha tekanyetso ea tlhokomelo ka mokhoa o le mong, e ka ba 80-320 mg ka letsatsi. Tekanyetso e le 'ngoe ha ea lokela ho feta 160 mg. Ha o fana ka tekanyetso e phahameng, o lokela ho nka moriana makhetlo a 2 ka letsatsi nakong ea lijo tse kholo.

Motsoako o khothalelitsoeng oa ho qala ho bakuli ba tsofetseng (lilemo tse fetang 65) ke matlapa a 40 mg (½) hang ka letsatsi. Haeba ho hlokahala, ho ea pele lethalinyana le ka eketsoa. Ho eketsa tekanyetso ea meriana ho lokela ho etsoa nako le nako ha bonyane matsatsi a 14 tlasa taolo ea methapo ea tsoekere ea mali.

Ka tekanyetso e nyane ea letsatsi le letsatsi (40-80 mg), Gliclazide e khothalletsoa ho bakuli ba nang le renal / hepatic insuffence, bakuli ba fokolitsoeng ke lefu, hape le bakuli ba kotsing ea ho ba le hypoglycemia: mathata a endocrine a tebileng kapa a sa fuoeng hantle, leqeba le matla la ho ruruha ha methapo (ho kenyelletsa le lefu le tebileng la coronary pelo, atherosulinosis e matla, atherosclerosis e matla ea methapo ea mokokotlo), ho se leka-lekane kapa khaello ea phepo e nepahetseng, peri Ho felisoa ha glucocorticosteroids kamora taolo ea bona ea nako e telele le / kapa tsamaiso litekanyetso tse phahameng.

Ha u fetisetsa mokuli ho Glyclazide ho tsoa ho moemeli e mong oa hypoglycemic ea molomo, nako ea phetoho ha e hlokehe. Tabeng ea ho nkeloa sebaka ke tokisetso e 'ngoe ea sulfonylurea ka nako e telele ea halofo ea bophelo (mohlala, chlorpropamide) ka gliclazide, ho hlahlojoa ka hloko boemo ba mokuli ho lokela ho netefatsoa ho qoba nts'etsopele ea phello e eketsang le hypoglycemia.

Haeba ho hlokahala, Gliclazide e ka khethoa hammoho le insulin, alpha-glucosidase inhibitors le biguanides.

Bakuli bao Glyclazide e sa laoleng ka ho lekana boemo ba tsoekere e maling e ka fuoa insulin. Phekolo e lokela ho etsoa tlasa taolo e tiileng ea ngaka.

Haeba u fetoa ke tekanyetso e latelang, ho thibetsoe ho nka tekanyetso habeli ka le hlahlamang.

Ho latela karabelo ea motho ka mong ea metabolic (glucose ea mali, glycated hemoglobin) ea mokuli, tekanyetso ea lithethefatsi nakong ea kalafo e ka fetoloa.

Litlamorao

ho tsoa ho lijo tsa ka mpeng: bohloko ba ka mpeng, lets'ollo / ho sokela, ho nyekeloa, ho hlatsa (botebo ba matšoao ana bo fokotsehile haeba u ka sebelisa lithethefatsi ka lijo),
lehlakoreng la sebete le pampitšana ea biliary: tšebetso e eketsehileng ea li-enzyme tsa sebete, choleundatic jaundice, hepatitis,
Ho tsoa lithong tsa hemopoietic: leukopenia, thrombocytopenia, anemia, granulocytopenia,
ho tsoa ho tsamaiso ea methapo ea pelo: epistaxis, hypotension ea methapo ea kutlo, ho se lekane ha methapo ea mali, arteritis, palpitations, ho nyekeloa ke pelo, tachycardia, infraction ea myocardial, ho ruruha ha leoto, thrombophlebitis,
Karolong ea setho sa pono: ho senyeha ha nakoana hoa pono (hangata qalong ea kalafo),
litla-morao: pruritus, erythema, lekhopho la letlalo (ho kenyelletsa ho sisinyeha ha maikutlo le maculopapular), urticaria, allergic vasculitis, angioedema.

Matšoao a mantlha a hypoglycemia: ho otsela, mokhathala, ho opeloa ke hlooho, ho tsekela, ho fokola, ho fufuleloa, ho tšoha, paresthesia, ho thothomela, ho thothomela, ho nyekeloa ke pelo, ho hlatsa. Liponahatso tse latelang hape lia khoneha: tlala, khatello ea maikutlo, ho hloka boroko, ho tšoha, ho ferekana, ho bua, ho ferekana, ho ferekanya maikutlo, ho ferekanya, maikutlo a ho hloka thuso, ho ferekana ha maikutlo, ho qoelisoa, ho ferekana, ho ferekana, ho felloa ke boitšoaro, ho tsitsipana, bradycardia, ho phefumoloha khafetsa. , khatello ea maikutlo, ho lahleheloa ke kelello. Hypoglycemia e ka lebisa ho komeng le lefung. Bakuli ba bang ba bonts'a matšoao a khahlano le adrenergic: ho fufuleloa, letlalo le ts'oanang, ho phahamisa mahlo, ho tšoenyeha, khatello e phahameng ea mali, angina pectoris, tachycardia, arrhythmia ea pelo - matšoao ana hangata a nyamela kamora ho nka limatlafatsi.

Bongata

Haeba ho na le overdose, hangata hypoglycemia ea hlaha.

Bakeng sa matšoao a itekanetseng, o lokela ho eketsa palo ea lik'habohaedreite ka har'a lijo, ho fokotsa tekanyetso ea Gliclazide le / kapa ho fetola lijo. Ho fihlela boemo bo tsitsitse ka botlalo, mokuli o lokela ho ba tlasa tlhokomelo ea bongaka.

Maemo a matla a hypoglycemic a ka tsamaisana le ho tsitsipana, komello le mafu a mang a amanang le methapo. Bakuli ba joalo ba hloka tlhokomelo ea bongaka ea tšohanyetso, ho hlokahala sepetlele kapele.

Haeba ho kula ho belaelloa ka ho ferekanya hypoglycemic coma, ho kenngoa ente e kenang kahare ea 50 ml ea tharollo ea 20-30% ea dextrose (glucose). E latelang, ho ts'oaroa ka tharollo ea 10% dextrose tharollo hoa hlokahala ho boloka maemo a tsoekere ea mali ka holimo ho 1 g / l. Bonyane matsatsi a mabeli a hloka ho hlahlojoa ka hloko. Phekolo e lokela ho tsamaea le ho beha leihlo mesebetsi ea bohlokoa ea 'mele.

Ho buoa ka lefu la tsoekere ha ho na thuso hobane gliclazide e tlama ho fihla ho protheine ea plasma haholo.

Litaelo tse khethehileng

Ho qoba kotsi ea ho ts'oaroa ke hypoglycemic, ngaka e lokela ho khetha lethal dose la Glyclazide ka hloko, e fe mokuli litlhahiso tse hlakileng tsa ho nka moriana, le ho hlokomela ho latela litaelo tsena.

Gliclazide e ka fuoa feela bakuli ba khonang ho fana ka lijo khafetsa, ho kenyelletsa le lijo tsa hoseng. Bohlokoa ba ho ja lijo tse nang le lik'habohaedreite ho bakoa ke kotsi e eketsehileng ea hypoglycemia haeba ho ka lieha lijo, lijo tse sa lekaneng kapa tse nang le lik'habohaedreite tse ngata. Kotsi ea hypoglycemia e eketseha ka lijo tse nang le khalori e tlase, tšebeliso ea joala, taolo e tšoanang ea lithethefatsi tse 'maloa tse tsoang sehlopheng sa sulfonylurea, le ka mor'a ho ikoetlisa ka nako e telele kapa ho sebetsa ka thata. Hypoglycemia e ka tsoaloa hangata 'me ea e-ba matla, e hlokang ho kena sepetlele ho mokuli le ho hlahisoa ha tsoekere ka matsatsi a' maloa.

Hypoglycemia e matla e ka etsahala ha u ntse u sebelisa lithethefatsi life kapa life tsa sulfonylurea. Bakuli ba fokolang le ba holofetseng, batho ba tsofetseng, bakuli ba nang le bothata ba ho hlonepha ka (adrenal insuffanele (bobeli ba mantlha le ba mahareng) ba kotsing e kholo.

Bakuli le ba malapa a bona ba hloka ho hlalosa kotsi ea maemo a hypoglycemic, ba bue ka matšoao a bona le mekhoa ea kalafo, hape le ho hlalosa lintho tse rerang nts'etsopele ea khatello ena. Mokuli o lokela ho utloisisa ka ho hlaka bohlokoa ba ho ja, ho ikoetlisa khafetsa le ho lekola nako le nako litekanyetso tsa tsoekere ea mali. Bakuli ba nang le lefu la tsoekere ba lokela ho lemosoa ka kotsi e eketsehang ea hypoglycemia haeba ho ka bolaoa tlala, ho nwa lino tse tahang le lithethefatsi tse seng khahlanong le ts'oaetso tsa mali.

Matšoao a hypoglycemia hangata a nyamela kamora ho ja lijo tse nang le lik'habohaedreite tse ngata tse kang tsoekere. Lisebelisoa tse tsoekere ha li sebetse. Leha ho na le liphallelo tsa pele tse atlehileng, hypoglycemia e ka khutla. Haeba matšoao a tebileng kapa a nako e telele a lemohuoa, le kamora ntlafatso ea nakoana le tšebeliso ea nama ea nama ea nama ea kolobe, ho hlokahala tlhokomelo ea bongaka, ho kenyelletsa le ho kena sepetlele.

Ts'ebetso ea taolo ea tsoekere ea mali nakong ea kalafo ea meriana ea lefu la tsoekere e ka fokotseha tlasa ts'usumetso ea lintlha tse latelang: feberu, bokuli bo matla, ho buoa, ho sithabela maikutlo, maemo a sithabetsang. Maemong a mang, ho ka hlokahala hore ho kenngoe insulin.

Ho sebetsa hantle ha matlapa a Gliclazide, joalo ka lithethefatsi tse ling tsa molomo tsa hypoglycemic, ho fokotseha ha nako e ntse e tsamaea. Sesosa sa boemo bona e ka ba tsoelo-pele ea lefu la tsoekere kapa karabelo e fokolisang ea moriana. Ketsahalo ena e bitsoa ho ba sieo hoa bobeli ha phello ea kalafo, ho fapana le ho haella ha mantlha ha ts'ebetso ea moriana. Qeto mabapi le khaello ea bobeli e ka etsoa feela kamora ho feto-fetoha ha tekanyetso ea tekanyetso le ho lekola tumellano ea mokuli le lijo.

Ho bakuli ba nang le khaello ea glucose-6-phosphate dihydrogenase, lithethefatsi tse tsoang sehlopheng sa sulfonylurea, ho kenyeletsa Glyclazide, li ka baka nts'etsopele ea anemia ea hemolytic. Tabeng ena, ho khothalletsoa ho nahana ka monyetla oa phekolo e 'ngoe ka moriana oa sehlopha se seng kapa ho sebelisa Glyclazide ka hloko e kholo.

Nakong ea ts'ebeliso ea Gliclazide, ho hlokahala hore nako le nako ho lekola mesebetsi ea liphio, sebete, tsamaiso ea methapo ea pelo le boemo ba ophthalmic. Ha ho hlahlojoa maemo a tsoekere ea mali, ho kgothaletswa ho lekanya litaba tsa "hemoglobin" ea glucose (kapa glucose ho "plousma" ea mali e potlakileng). Ntle le moo, ho itlhahloba ha khatello ea tsoekere ho ka ba molemo ho bakuli.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Gliclazide ha e ame kapa e na le phello e fokolang mesebetsing ea psychophysical ea motho. Leha ho le joalo, nakong ea kalafo, haholo-holo qalong ea kalafo, bakhanni ba likoloi le batho ba sebetsang indastering e ka bang kotsi ba lokela ho ba hlokolosi ka kotsi ea hypoglycemia.

Bokhachane le pelehi

Ho na le lintlha tse fokolang tsa kliniki mabapi le ts'ebeliso ea gliclazide nakong ea kemolo. Ho na le tlhahisoleseling mabapi le tšebeliso ea litokisetso tse ling tsa sulfonylurea.

Lithutong tsa liphoofolo, ho fumanoe boteng ba chefo ea ho beleha maemong a tekanyetso e phahameng ea gliclazide.

E le tšireletso, lithethefatsi ha li khothalletsoe basali baimana. Leha ho le joalo, molemong oa ho qoba ho ba le mathata a tlhaho ea tlhaho ho bana, ho hlokahala tlhokomelo e hlokolosi ea lefu la tsoekere ho mme. Li-antidiabetesic agents ha li sebelisoe ho basali baimana, insulin ke lithethefatsi tsa khetho. Ha ho rera ho ima le haeba ho ima ho etsahetse ha o ntse o nka gliclazide, ho kgothaletswa ho nka meriana ea molomo ka kalafo ea insulin.

Ha ho tsejoe hore na moriana o kenella ka lebeseng la mme, kamanong le sena, Glyclazide e tšoaelitsoe nakong ea ho beleha.

Ho sebelisana le lithethefatsi

Ts'ebeliso e kopaneng ea miconazole e hanyetsanoe (ka liforomo tsa methapo ea methapo kapa mofuta oa li-gel bakeng sa ts'ebetso ho li-mucous membrous ea cavity ea molomo), kaha e eketsa phello ea gliclazide mme, ka lebaka leo, e eketsa kotsi ea hypoglycemia e matla, ho fihla ho komisi.

Ha e khothalletsoe motsoako:

phenylbutazone (ka mefuta ea litekanyetso bakeng sa ts'ebeliso ea systemic): e ntlafatsa phello ea hypoglycemic ea sulfonylureas. Ho khothalletsoa motsoako o mong o khahlanong le ho ruruha. Haeba sepheo sa ho kopanya joalo se lokiselitsoe ka nepo, maemo a tsoekere ea mali a lokela ho betoa leihlo haholoanyane, haeba ho hlokahala, lokisa tekanyetso ea glyclazide (ka bobeli nakong ea phekolo e kopaneng le kamora ho tlosoa hoa phenylbutazone),
ethanol: e ntlafatsa haholo hypoglycemia 'me e ka baka leqeba la hypoglycemic.Bakeng sa nako ea kalafo, o lokela ho tlohela tšebeliso ea lino tse tahang le ho sebelisa lithethefatsi tse nang le ethanol,
danazol: e na le lefu la tsoekere; tsamaiso ea eona ha e khothalletsoe nakong ea kalafo ea hypoglycemic. Leha ho le joalo, haeba tsamaiso e hlokahala, tekanyetso ea Gliclazide e lokela ho lokisoa.

Mekhaako e hlokang ho ba seli:

li-agents tse ling tsa hypoglycemic (insulin, acarbose, biguanides), beta-blockers, angiotensin-converting enzyme inhibitors (enalapril, Captopril), fluconazole, histamine H blockers₂-receptors, sulfonamides, lithethefatsi tse seng khahlanong le ts'oaetso tsa lithibela-mafu, chlorpromazine e nang le litekanyetso tse phahameng, li-inhibitors tsa monoamine oxidase: ntlafatsa sephetho sa hypoglycemic le ho eketsa kotsi ea hypoglycemia. Ho khothalletsoa taolo ea glycemic ka hloko le khetho ea Gliclazide.
tetracosactide, glucocorticosteroids bakeng sa ts'ebeliso ea systemic le ea lehae (intraarticular, subcutaneous, cutaneous, rectal): Ho eketsa tsoekere ea mali ka nts'etsopele ea ketoacidosis (ho fokotseha ha mamello ho lik'habohaedreite). Ho laoloa ka hloko ha glycemic ho hlokahala, haholo-holo qalong ea kalafo ea hypoglycemic, le tokiso ea litekanyetso tsa glycazide,
beta₂-adrenomimetics (terbutaline, salbutamol, ritodrin): eketsa tsoekere ea mali, ka hona, maemo a tsoekere ea mali a lokela ho hlahlojoa ka hloko. E kanna ea hloka phetisetso ea mokuli ho insulin,
gliclazide le tse ling tse tsoang teng ka sulfonylurea: hoa khoneha ho ntlafatsa ketso ea li-anticoagulants, tse hlokang tokiso ea litekanyetso.

Litlhahlobo mabapi le Gliclazide

Ho latela maikutlo, Gliclazide ke moemeli ea sebetsang oa lithibela-mafu. Hajoale, li-sulfonylureas tsa moloko oa bobeli li sebelisoa haholo, hobane li feta moloko o fetileng ka tekanyo ea phello ea hypoglycemic, 'me ho ka khoneha ho fihlela sephetho se ts'oanang ha u fana ka litekanyetso tse tlase. Ntle le moo, lichelete tsa sehlopha sena ha li na monyetla oa ho baka litlamorao.

Litsebi tsa bongaka li bontša hore nakong ea biotransformation ea gliclazide, metabolite le eona e thehiloe, e nang le phello e ntle ho microcirculation. Boithuto bo bongata bo netefalitse hore lithethefatsi li fokotsa kotsi ea mathata a li-microvascular (nephropathy, retinopathy), nts'etsopele ea angiopathy. Ntle le moo, e ntlafatsa phepo e kopaneng, e tlosa masapo a mokokotlo. Mabapi le sena, khetho ea Gliclazide e nepahetse bakeng sa mathata a lefu la tsoekere a kang ho se sebetse hantle ha renal, lephropathy, retinopathy le angiopathy.

Ho na le litlaleho tsa hore lilemo tse 'maloa (lilemo tse 3-5) kamora ho qala ho sebelisa lithethefatsi, maikutlo a kalafo a fokotseha. Maemong a joalo, ho khethoa ha moemeli ea eketsehileng oa hypoglycemic hoa hlokahala.

Matlapa a Glyclazide

Litokisetso tsa hypoglycemic bakeng sa tsamaiso ea molomo, e leng sulfonylurea ea moloko oa bobeli, li na le litlamorao tse fapaneng tsa kalafo ea meriana. Glyclazide e fumaneha ka mokhoa oa litafole tsa 80 mg kapa 30 le 60 mg ka tokollo e fetotsoeng. Setlhare se ipakile se sebetsa, ka hona, hangata se fanoa e le ho etsa hore tsoekere ea mali e be e tloaelehileng.

Matlapa a Glyclazide 30 mg a na le sebopeho se chitja, se sephara-cylindrical, ho na le chamfer, 'mala o mosoeu kapa o batla o le mosoeu (o mosehla kapa o moputsoa) Pilisi ea 60 mg e kotsing. Ntho e sebetsang ke gliclazide. Sebopeho sa moriana:

gliclazide-30 kapa 60 mg

silicon dioxide e kolloidal

sodium stearyl fumarate

Matšoao a ho sebelisoa

Gliclazide ea lithethefatsi e sebelisoa haholo bakeng sa lefu la tsoekere la mofuta oa 2 le hyperglycemia. Ho amohela ho bohlokoa haholo ha ho na le katleho e fokolang ea kalafo ea ho ja, mekhoa ea ho fokotsa index ea boima ba 'mele le boikoetliso bo khethehileng ba' mele. Glyclazide e sebetsa hantle ho thibela mathata a mofuta oa lefu la tsoekere la mofuta oa 2: nts'etsopele ea methapo ea methapo ea methapo (lefu la stroke, myocardial infarction) le mathata a microcirculatory (retinopathy, nephropathy).

Litaelo tsa ho sebelisoa Gliclazide

Qeto mabapi le boholo ba tekanyetso ea ho amoheloa ka hyperglycemia e hlahisoa motheong oa litekanyetso: lilemo, ho teba ha tsoekere, le tsoekere ea mali pele ho ja le lihora tse peli ka mor'a ho ja. Motsoako oa pele o khothalletsoang ke 40 mg ka lijo. Tekanyetso ena e khothalletsoa ho bakuli bohle, ho kenyeletsa le ba baholo. Tekanyetso ea pele ea letsatsi le letsatsi ke 80 mg. Ho ea pele, ho latela liparamente, karolelano ea li-mg mg tse 160 ka letsatsi. Phetoho ea litekanyetso e etsoa ho ipapisa le nako ea libeke tse peli.

Tekanyetso e kholo e lumelletsoeng ke - 320 mg. Haeba u tlil'o sebelisa moriana ona, ha ho hlokahale hore u eketse lethal dose ka le hlahlamang. Litekanyetso tsa bakuli ba tsofetseng, hammoho le bakuli ba nang le ho fokolisa ha methapo ea mokokotlo, ha li fapane. Ho nwa moriana ho lokela ho tsamaisana le taolo ea tsoekere ea mali ho thibela hypoglycemia (khatello ea glucose e eketsehileng).

Glyclazide MV 30 mg

Motsoako oa Gliclazide o fetotsoeng, o ka tloha ho 30 ho isa ho 120 mg. Ho amohela ho etsahala hoseng ka lijo. Haeba u tlola ho sebelisa moriana bakeng sa hyperglycemia, matšeliso a thibetsoe ka ho eketsa lethal dose ka le hlahlamang. Qeto ea litekanyetso e etsoa ka bonngoe. Motsoako oa pele ke 30 mg. Maemong a ho hloleha ha sephetho, lethalinyana butle-butle (hang ka khoeli) le nyolohela ho 60, 90 le 120 mg. Gliclazide MB e kanna ea kopana le insulin. A re ke re nahane ka phetoho e ka bapisoang le ho tloha ho nka Gliclazide 80 ho ea Gliclazide MV 30 mg ka mora ho ts'oaroa tsoekere.

Lipehelo tsa thekiso le polokelo

Moriana o lokela ho bolokoa sebakeng se lefifi ntle le mongobo ka mocheso o sa feteng 25 degrees. Gliclazide e lokela ho sireletsoa ho bana. Bophelo ba Shelf ke lilemo tse tharo. E fanoe ke lengolo la ngaka.

Ka har'a 'maraka oa limela oa lapeng ho na le li-analogues tse' maloa tsa Gliclazide. Tse ling tsa tsona li na le ntho e tšoanang e sebetsang, karolo e 'ngoe e lumella ho fihlella phello e tšoanang ea kalafo. Meriana ena e latelang ke papiso ea lingaka:

Glyclazide Canon,
Glidia MV,
Gluconorm,
Gliklada
Sethala
Glucetam
Lefu la tsoekere
Diabresid
Lekola.

Datha ea mahlale a drug

Moemeli oa Hypoglycemic bakeng sa tsamaiso ea molomo. Sehlahisoa se entsoe e le sehlahisoa sa sulfonylurea ea bobeli. E thusa ho hlahiseng insulin ke lisele tsa pancreatic. Eketsa kutloisiso ea lisele tsa peripheral ho insulin. Fokotsa nako e pakeng tsa lijo le ho qala ha tlhahiso ea insulin.

Tekanyetso le sebopeho sa matlapa "Gliclazide"

Ha e kenella ka mpeng, moriana o robeha ka potlako kahare. Kamora lihora tse 4, 80 mg e kenella maling le phofo e le 'ngoe ea moriana. Hoo e ka bang 100% e kopana le liprotheine tsa mali. E qhibiliha ka har'a sebete 'me e theha metabolites e se nang thepa ea hypoglycemic, empa e ka ama microcirculation feela. E tšeloa moroto har'a motsehare.

Qalong ea kalafo, 80 mg e khethoa hang ka letsatsi. Boholo bo ka nooa 160-220 mg habeli ka letsatsi. Matlapa a nooa pele ho lijo. Hape, litla-morao li ipapisitse le lefu le boemo ba tšenyo ea manyeme. U ka arolelana ba bang molaetsa. Letlapa le le leng le nooa ka mpeng e se nang letho, 'me lihora tse peli ka mor'a lijo, pheta litekanyetso. U ka sebelisa "Glyclazide" joang? Litaelo tsa ho sebelisoa. Theko, analogues, litekanyetso tse nepahetseng - ngaka e tla u bolella ka sena sohle.

Ho sebelisana le lithethefatsi tse ling

Matlapa a Glyclazide a felloa ke matla ha a nooa hammoho le lithethefatsi tse ling. Tsena ke li-derivatives tsa pyrazolone, lithethefatsi tsa antibacterial sulfonamide, li-inhibitors tsa MAO, theophylline, caffeine.

Ka tsamaiso e ts'oanang ka li-beta-blockers tse sa khethang, nts'etsopele ea hypoglycemia e eketseha, tachycardia le matsoho a thothomelang, ho fufuleloa, haholoholo bosiu.

Ha o sebelisa sehlahisoa sa litlama "Cimetidine" ka har'a plasma, litaba tsa matlapa a "Gliclazide" lia eketseha. Sena se ka lebisa ho hypoglycemia e matla. Ka tsamaiso e tšoanang ea litafole tsa Glyclazide le meriana ea Veropomila, ho loketse ho laola boemo ba tsoekere ea mali.

Hape, hammoho le ho nka GCS, matlapa a Glyclazide a theola thepa ea bona ea hypoglycemic. Lithethefatsi tse joalo li kenyelletsa diuretics, barbiturates, estrogens, le lithethefatsi tse ling tsa anti-TB. Ka hona, ho bohlokoa ho etsa tlhahlobo e felletseng ea 'mele pele u sebelisa lithethefatsi "Gliclazide." Litaelo tsa tšebeliso, theko, analogues, litlamorao tse ka bang teng - tsena tsohle li lokela ho tsejoa esale pele.

Matšoao a ho nka matlapa a Glyclazide

Moriana o fuoa lefu la tsoekere la lefu la tsoekere la mofuta oa bobeli o boima, ha ho se ho sa itšetleha ka insulin. Le mehato ea thibelo ea mathata a microcirculatory. Setlhare se sebelisoa tlasa taolo ea ngaka. Pele, o tlameha ho etsa tlhahlobo ea tsoekere ea mali. Etsa bonnete ba hore o latela lijo nakong ea kalafo, fokotsa ho ja letsoai le lik'habohaedreite tse ngata. Lahla ho nka phofo le tsoekere.

Gliclazide mv

Matlapa a Glyclazide mv a ipakile a le hantle. Litaelo tsa tšebeliso li tla bua ka li-contraindication le litlamorao tsa sethethefatsi sena. E sebelisetsoa ho phekola lefu la tsoekere le sa itšetleheng ka insulin ka tekano e tebileng. U ke ke ua noa moriana ona bakeng sa lefu la tsoekere la mofuta oa pele, ka methapo ea sebete le ea liphio. Nakong ea bokhachane le pelehi, ho ntsa moriana ona ho thibetsoe ka thata.

Phekolo e lokela ho tsamaea le taolo ea tsoekere. Har'a litla-morao, ho nyekeloa, ho hlatsa, lets'ollo le bohloko bo ka mpeng bo ka bonoa. Maemong a sa tloaelehang, phokolo ea mali le leukopenia lia ntlafala. Ka karohano e sa kulang ea lintho tse itseng tsa letlapa, lekhopho le ka hlaha. Gliclazide mv e na le lithethefatsi tse 'maloa tseo ho tsona ho se lumellanang. Tsena ke diuretics, barbiturates, estrogens, meriana ea aminophylline. Ehlile, litaelo tsa tšebeliso li lokela ho ithutoa pele u qala kalafo ka litafole tsa Glyclazide mv. Theko ea sehlahisoa ha e fetang li-ruble tse 500.

Setlhare sa molomo sa hypoglycemic. Matlapa a tšoeu, a hanyane hanyane. Mahlakoreng ka bobeli ho na le matšoao a DIA 60. Sena se fana ka maikutlo a hore moriana o laetsoe. Ona ke mokhoa o motle oa ho sebelisa litlhare.

Sebopeho sa moriana se kenyelletsa "glycazide ntho". Moriana o fuoa feela batho ba baholo. U hloka ho noa Letlapa le le leng hang ka letsatsi. Sena se etsoa hantle nakong ea lijo tsa hoseng. Ho latela mofuta oa lefu la tsoekere le boemo bo akaretsang, litekanyetso li ka eketsoa litafoleng tse peli ka letsatsi. Matlapa a Glyclazide a na le mofuta o tšoanang oa litekanyetso. Litaelo tsa tšebeliso li hlalosa ntho e 'ngoe le e' ngoe ka ho qaqileng.

Ha u sebelisa tekanyetso e phahameng ea lithethefatsi, hypoglycemia e ka hlaha. Boemong bona, ho potlakile ho batla thuso ho setsebi. E na le li-contraindication tsohle le litlamorao tse tšoanang le pheko ea "Gliclazide mv". Litaelo tsa tšebeliso, theko, litekolo - tsena tsohle li lokela ho ithutoa pele ho qala kalafo.

Maikutlo mabapi le lithethefatsi "Gliclazide"

Hangata, o ka utloa mantsoe a monate ka lipilisi. Bakuli ba hlokomela hore moriana o thusa ho laola tsoekere ea mali mme o kenya letsoho bophelong bo tloaelehileng. Ntho feela e sa ferekaneng ke hore moriana o nooa ka tieo ho latela morero. Ho sebelisa joala bo bongata ho ka ba kotsi haholo.

Theko ea Gliclazide libakeng tsa meriana

Ngoliso ea lithethefatsi e felile, ka hona theko ea Gliclazide ha e tsejoe. Litšenyehelo tse ka bang tsa li-analogu tse ling:

Gliclazide MV - li-ruble tse 115-1444. ka pakete e 'ngoe ea litafole tse 60 tsa 30 mg,
Glidiab - li-ruble tse 107-151. ka pakete e 'ngoe ea litafole tse 60 tsa 80 mg,
Diabeteson MV - li-ruble tse 260-347. ka pakete e le 'ngoe ea matlapa a 30 a 60 mg.