Ofloxin e fumaneha ka tsela ea matlapa a biconvex a mmala o mosoeu ntle le litšila le monko. Matlapa a koahetsoe 'me a na le kotsi e arohanang. Ho latela litekanyetso, mongolo o ngotsoe ho e 'ngoe ea mahlakore "200"Kapa"400". Kink - e hatisitsoeng boima bo tšoeu.

Metsi a lisele tsa Contour cell a behiloe ka lebokoseng la karete.

Pokello ka 'ngoe e tlameha ho ba le litaelo tse qaqileng bakeng sa ts'ebeliso ea moriana.

Pharmacodynamics le pharmacokinetics

Ofloxacin Ke moemeli oa antimicrobial o nang le bongata bo bongata ba ketso ea bactericidal. Ke oa sehlopha. fluoroquinolones. Ofloxacin e na le phello e kholo ho encyme ea DNA gyrase, e fanang ka DNA ea baktheria e ntle haholo. Setlhare sena se thefula ketane ea DNA, e lebisang lefung la likokoana-hloko.

Ofloxacine na le ts'ebetso e phahameng khahlanong le likokoana-hloko tse hlahisang β-lactamases, hape e sebelisetsoa ho loants'a li-Microbacteria tse holang ka potlako joalo ka Enterobacteriaceae (Salmonella, Serratia, Citrobacter, Klebsiella, Yersinia), Escherichia coli, Enterobacter spp., Shigella spp., Providencia spp., Proteus spp.

Setlhare se boetse se sebetsa khahlano le staphylococcus (ho kenyelletsa likarolo tse hlahisang penicillin le methicillin e thibelang mafu (Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium tuberculosis Mycobacterium leprae, Ureaplasma urealyticum).

Setlhare se boetse se bonts'a litlamorao tse ntle kalafong ea mafu a bakoang ke microbacteria e latelang: Pasteurella multocida, Pseudomonas spp., Brucella melitensis, Haemophilus influenzae, Campylobacter sp., Neisseria meningitidis, Branhamella catarrhalis, Vibrio sp., Pseudomonas aeruginosa.

Ho khothalletsoa ho sebelisa sethethefatsi sena ka popelo e sebetsang. Helicobacter pylori, Acinetobacter sp., Neisseria gonorrhoeae, Haemophilus ducreyi, Gardnerella vaginalis.

Ofloxin ha e sebetse khahlano le mafu a tšoaetsanoang a bakoang kestreptococci ea sehlopha A, B, C. Hape, li-anaerobes, ntle le Clostridium perfringens. Maemong ana, ofloxacin e na le phello e fokolang mme, haeba ho khonahala, ho molemo ho sebelisa lithethefatsi tse ling ho liehisa tlhahiso ea libaktheria tsena.

Libaktheria tsa Anaerobic ha li na kutloelo-bohloko ka botlalo ho moriana Fusobacterium spp., Bacteroides spp., Peptococcus spp., Le Peptostreptococcus spp.

Ofloxin ha e sebetse kamanong le Treponema pallidum.

Suction

Ha o sebelisa sethethefatsi, ho monya ho phethehile (95%) ebile ho potlakile. Bioavailability e feta 96%. Сmax ha o sebelisa moriana o lekantsoe ka 100 mg, 300 mg le 600 mg o fihla ho 1 mg / l, 3,4 mg / l le 6.9 mg / l, ka ho latellana. Ka tekanyetso e le 'ngoe ea moriana ka tekanyetso ea 200 mg le 400 mg, Cmax e fihla ho 2,5 μg / ml le 5 μg / ml. Re lokela ho hlokomela hore ho ja haholo ho fokotsa ho monya, empa ha ho ame haholo bioavailability.

Tsamaiso

Ho tlangoa ha ofloxacin le liprotheine tsa plasma ke 20-25%. Vd e hlahelletseng e fihla ho lilithara tse 100.
Setlhare se kenella habonolo metsing a mangata a mmele le lisele tsa hae (mokelikeli o tsoang ka bongata le mokelikeli, moroto, mathe, secretion ea bronchial, jj.) Ofloxacin le eona e kenella ka bolokolohi ho placental barter le BBB, mme e pepesoa lebese la matsoele. Matla a kenellang a moriana ka har'a mokelikeli oa "cerebrospinal" a fapana ho tloha ho 14 ho isa ho 60%. Ofloxacin ha e qale.

Metabolism

Metabolism le hlaha ka har'a sebete. Dimethylofloxacin le ofloxacin N-oxide li thehiloe.

Ho tsala

T1 / 2 ha e fanoa ka molomo, ho sa natsoe lethal dose, e hloekisoa kamora lihora tse 4,5-7. Excretion e etsoa ke liphio (75-90%) le bile (4%). Tlhahiso e eketsehileng e batla e le 20%. Bakuli ba nang le bothata ba ho renal kapa hepatic ba lokela ho hopola hore T1 / 2 ea lithethefatsi e ea eketseha. Ka tekanyetso e le 'ngoe ea 200 mg, ofloxacin e ka bonoa ka har'a moroto nakong ea lihora tse 20-25.

Matšoao a ho sebelisoa

Ofloxin e ipakile e le kalafong ea:

• tšoaetso e matla ea phefumoloho (lefu la bronchiectatic, lesapo la matšoafo,pneumonia),
• Tšoaetso ea ENT (media oa otitis, sinusitis, pharyngitis, laryngitis / ntle le acillus ea makhopho /),
• tšoaetso ea masapo le manonyeletso,
• lisele tse bonolo le letlalo,
• mafu a tšoaetsanoang le a tšoaetsanoang a litho tsa ka mpeng (lesapo la mokokotlo, tšoaetso ea phepelo ea lefu la biliary / ntle le bacterial Enteritis /),
• tšoaetso ea liphio (pyelonephritis),
• ts'oaetso ea pampitšana ea urinary (urethritis, cystitis),
• tšoaetso ea pelvic (endometritis, salpingitis, cervicitis, parametritis, prostatitis),
• tšoaetso e matla ea setho sa botšehali (orchitis, colpitis, epididymitis, gonorrhea, prostatitis),
• meningitis,
• chlamydia,
• mafu a kopaneng le Motsoako,
• tšoaetso ea mahlo (conjunctivitis, bakuli ba ka mpeng ea cornea, blepharitis, dacryocystitis, meibomite, keratitis).

Ofloxin e sebelisoa hape ka mafolofolo:

• thibelong ea mathata a tšoaetsanoang ka mor'a ho buuoa mabapi le ho tlosoa ha 'mele o lemetseng kapa likotsi tsa mahlo,
• ka phekolo e rarahaneng lefuba,
• ka thibelo ea tšoaetso ho bakuli ba immunodefitness (neutropenia).

Contraindication

U lokela ho hana ho nka Ofloxin:

• ho tsoekere ea glucose-6-phosphate dehydrogenase,
• ho lefu la sethoathoa (ho kenyeletsa nalane),
• hoe theola monyako oa tsietsing (ho kenyeletsoa ka mora stroke, hlooho e opang kapa mekhoa efe kapa efe ea ho ruruha e tsamaisong ea methapo e bohareng).

• batho ba ka tlase ho lilemo tse 18
• batho ba nang le hypersensitivity ho likarolo tsa moriana.
• basali baimana
• basali nakong ea kemaro.

Ka tlhokomeliso, sethethefatsi se lokela ho sebelisoa ho batho ba nang le mafu a amanang le ho potoloha ha lets'ollo le " cerebral arteriosulinosis. Ho ho se sebetse hantle hantle ha renal le liso tsa tlhaho tsa tsamaiso ea methapo e bohareng ho bohlokoa ho khetha litlhare tsa kalafo tse nang le ts'ebetso e ts'oanang, empa e se kotsi.

Litlamorao

Nakong ea kalafo le Ofloxin, mokuli a ka ikutloa a sa phutholoha 'me a tšoeroe ke:

• Ka tsamaiso ea tšilo ea lijo: ho nyekeloa, ho hlatsa, lets'ollo, ho hlonepha, bohloko ba ka mpeng(ho kenyeletsa gastralgia), ho eketsa tšebetso ea transpases tsa hepatic, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis.
• Ka tsamaiso ea methapo ea kutlo le CNS:hlooho e opang, ho tsekela, ho se sireletsehe ha motsamao, ho thothomela, makhopho, ho akheha le li-paresthesias tsa maoto le litoro, litoro tse matla, litoro tse bohloko, maikutlo a kelello, matšoenyeho,ho se khonehephobias, khatello ea maikutlo, pherekano, hallucinationskhatello e eketsehileng ea makatsang.
• Ka litho tsa kutlo: matšoao a ho khetholla mebala, diplopia,ho ferekana ha tatso, ho utloa, ho fofonela le ho leka-lekana.
• Ka tsamaiso ea methapo ea pelo: tachycardia, vasculitis, ho oa.
• Ka tsamaiso ea musculoskeletal: tendonitis, myalgia, arthralgia, tendosynovitis, ropo ea tendon.
• Ka hematopoietic system: leukopenia, agranulocytosis, phokolo ea mali, thrombocytopenia, pancytopenia, hemolytic le anemia ea aplasiki.
• Ka litsamaiso tsa methapo: acute interstitial nephritis, ho sitisoa ha renal, hypercreatininemia,keketseho ea litaba tsa urea.
• Litla-morao:lekhopho la letlalo, ho hlohlona, ​​urticaria, lefu la ho ferekana ha mmele, ho ferekana, feberu, edincke's edema, bronchospasm, Stevens-Johnson syndrome, lefu la Lyell, photosensitivity, erythema multiforme, anaphylactic.
• Boitšoaro ba letlalo: hemorrhages (petechiae), lefu la hemorrhagic dermatitis, leqhetsoana la papular, vasculitis.
• Hape: dysbiosis, bonohe, hypoglycemia(ho bakuli lefu la tsoekere), vaginitis.

Litaelo tsa tšebeliso ea inloxine (mokhoa le litekanyetso)

Ka lebaka la hore Ofloxin e sebelisetsoa ho phekola mafu a mangata, tekanyetso ea lithibela-mafu ena e khethoa ka bonngoe mme e sa itšetleha feela ka boteng le tšoaetso ea tšoaetso, empa hape le ka boemo bo akaretsang ba mokuli. Litaelo tsa Ofloxin 400 mg li lokela ho fuoa tlhokomelo e khethehileng ts'ebetsong ea sebete le a liphio.

Batho ba baholo ba fuoa lethal la 200 mg makhetlo a 2 ka letsatsi, kapa 400 mg 1 nako e le ngoe ka letsatsi. Tekanyo e phahameng ka ho fetisisa ka letsatsi ha ea lokela ho feta 800 mg. Nako ea kalafo e khethoa ke ho hlaka hoa pathogen 'me hangata hangata ke matsatsi a 7-10. Nka sethethefatsi ka ho khetheha hoseng metsotso e 30-60 pele u ja. - Nwa matlapa ka metsi a manyane.

Pele u qala ho sebelisa lithethefatsi, o lokela ho etela ngaka kamehla, kaha litekanyetso tsa kalafo ea mafu a fapaneng li ka fapana.

Tšebelisano

Ha o kenya moriana kahare, o lokela ho hopoloa hore o fokotsa ho monya haholo tsaloxacinLihlahisoa tsa lijo tse nang le calcium e ngata, aluminium, magnesium, le letsoai la tšepe, kaha li theha mechini e sa sebetseng hantle. Ho lokela ho netefatsoa hore karohano lipakeng tsa tsamaiso ea Ofloxin le lintho tsena ke bonyane lihora tse 2.

Moketeng oa kamohelotsaloxacin25% e fokotsehile theophylline clearance mme ho bohlokoa maemong ana ho fokotsa tekanyetso theophylline.

Ho lebisoa tlhokomelo e khethehileng ho lithethefatsi tse thibelang secretion ea tubular, kaha tsamaiso ea bona ka nako e le 'ngoe le Ofloxin e ka eketsa haholo khatello ea pllo ea plasma.

Phokotso Glibenclamide ho plasma e boetse e itšetlehile ka Ofloxin.

Ofloxin ha ea lokela ho nkoa bahanyetsi ba vitamini Kkaha sena se ka ama boemo bona tsamaiso ea methapo ea mali.

Mehloli nitroimidazolele methylxanthineha e kopane e ka baka kholo litlamorao tsa neurotoxic, le GKS e eketsa kotsi ea ho phatloha ha tendon, e leng kotsi haholo ho batho ba tsofetseng.

Ho nka litlolo tse nang le moroto tse alkalize ho ka lebisa kotsing e kholo ea ho hlaha le ho hola nephrotoxic litlamoraolekrystalluria.

Letsatsi la ho felloa ke nako

Ofloxin o phela bophelo ba setebele lilemo tse tharo.

Hajoale, Ofloxin e na le li-analogu tse ka bang 20 tse tsoang ho baetsi ba malapeng le ba kantle ho naha. Lithethefatsi tse tsebahalang kajeno ke: Zanocin, Ofloxacin, OflocidleLoflox.

Lintho tse ling tse sebelisang moelelo oa ntho e sebetsang ke: Vero Ofloxacin, Glaufos, Danzil, Uniflox, Phloxal.

Litlhahlobo tsa Ofloxine

Pholo ea Ofloxin liforong e fapana ho tloha ho 1 ho isa ho 5 ka tekanyo ea lintlha tse 5.

Kamora ho hlahloba litlhahlobo tsa baeti liforong tsa bongaka, re ka fihlela qeto ea hore bakuli ba ileng ba qeta kalafo e felletseng ba khotsofetse ka ho felletseng ka liphetho tsa kalafo. Lipalo tse tlase bakeng sa lithethefatsi li ne li fuoa hangata ke baeti bao Ofloxin a ileng a ba le litlamorao tse mpe ka ho fetisisa. Hangata, liforong, bakuli ba tletleba ka bohloko bo tebileng ka mpeng. takatso e fokotsehilengponahalo ho sithabela, ho lapa, ho otsela esita le bosiuhallucinations.

Na alloxin ke lithibela-mafu kapa che?

Puisano e ngata ka liforamu e fanoe ka taba ena. Ebe litsebi li fana ka karabo e hlakileng ea hore Ofloxin ke lithibela-mafu tse matla, 'me ba eletse bakuli ba nang le lithethefatsi tsena ba etsa hore ba utloe bohloko ba ho khetha meriana e se nang chefo bakeng sa kalafo.

Ha ho na tlhaiso-leseling ka lithethefatsi Ofloxin ho Wikipedia.

Ofloxacin

Litheko tsa litlhare tsa marang-rang:

Ofloxacin ke sethethefatsi se bolaeang likokoana-hloko se nang le bongata bo bongata ba ketso ea bactericidal. Ke ea sehlopha sa fluoroquinolones.

Tekanyetso le tsamaiso

Litekanyetso tsa lithethefatsi li khethoa ka bonngoe, ho ipapisitse le maemo a akaretsang a mokuli, a renal le hepatic, ho teba le ho tsebahatsa ts'oaetso le ho hlaseloa ha likokoana-hloko.

Matlapa a koahetsoeng

Matlapa a etselitsoe ho tsamaisoa ka molomo pele ho nako ea lijo. Li lokela ho metsoa li felletse, ntle le ho hlafuna, li hlatsuoe ka metsi.

Tekanyetso e khothalletsoang ho batho ba baholo ke 200-800 mg ka letsatsi ho litekanyetso tse peli tse arohaneng. Nako ea kalafo ke matsatsi a 7-10. Haeba tekanyetso ea letsatsi le letsatsi e sa feta 400 mg, e ka fuoa tekanyetso e le 'ngoe, ka ho khetheha hoseng.

A gonorrhea e hlobaetsang, Ofloxacin e sebelisoa ka tekanyo ea 400 mg hang.

Tharollo ea infusion

Tharollo e fanoa ka matla.

Tekanyetso ea pele ea Ofloxacin ke 200 mg kahare (ka nako ea metsotso e 30-60). Ha boemo ba mokuli bo ntlafala, ba fetisetsoa moriana o kahare ka tekanyetso e tšoanang ea letsatsi le letsatsi.

• Tšoaetso ea litho tsa botona le tsa liphio - 100-200 mg makhetlo a 2 ka letsatsi,
• Tšoaetso ea pampitšana ea urinary - 100 mg makhetlo a 1-2 ka letsatsi,
• Tšoaetso ea ts'oaetso ea ts'oaetso ea ts'oaetso ea lefu le tšoaetso ea litho tsa ENT, tšubuhlellano ea matšoafo, ho hema ka mpeng, masapo a bonolo le letlalo, manonyeletso le masapo - makhetlo a 200 ka makhetlo a mabeli ka letsatsi (haeba ho hlokahala, eketsa lethalinyana ho isa ho 400 mg makhetlo a 2 ka letsatsi),
• Thibelo ea tšoaetso ho bakuli ba nang le boemo bo bobe ba ho itšireletsa mafung - 400-600 mg ka letsatsi.

Maemong a mosebetsi o sa sebetseng oa renal (clearinine clearance of 20-50 ml / min), tekanyetso e le 'ngoe e lokela ho fokotsoa ke 50% ea tekanyetso e tloaelehileng (haeba moriana o nooa habeli ka letsatsi) kapa tekanyetso e le' ngoe e ts'oanetseng e lokela ho beoa, empa nako e le ngoe ka letsatsi. Ka tumello ea creatinine e ka tlase ho 20 ml / min, tekanyetso e le 'ngoe ke 200 mg, ebe 100 mg ka letsatsi letsatsi le leng le le leng.

Ka peritoneal dialysis le hemodialysis, Ofloxacin e beoa 100 mg ka lihora tse ling le tse ling tse 24.

Ka ho hloleha ha sebete, tekanyo e phahameng ka ho fetisisa ka letsatsi ke 400 mg.

Bakeng sa bana ba nang le ts'oaetso e matla, moriana o laetsoe ka tekanyetso e tloaelehileng ea letsatsi le letsatsi ea 7.5 mg / kg ea boima ba 'mele, ka tekanyo e phahameng ea 15 mg / kg.

Nako ea kalafo e itšetlehile ka kutloisiso ea pathogen le setšoantšo sa kliniki ea lefu lena. Phekolo e ntse e tsoela pele matsatsi a mang a 3 kamora ho nyamela hoa matšoao a lefu le tšoaetsanoang le ho tloaela mocheso oa mmele. Ka ts'oaetso e sa rarahanang ea moroto, mokhoa oa phekolo ke matsatsi a 3-5, ka salmonellosis - matsatsi a 7-8.

Setlolo

Setlolo sa Ofloxacin se sebelisoa haholoholo. Moriana o tšeloa ka leihlo le ka tlase la leihlo le amehileng (lehare la mafura a bolelele ba 1 cm, le lumellanang le 0.12 mg ealoxacin) makhetlo a 2-3 ka letsatsi. Ka tšoaetso ea chlamydial, moriana o sebelisoa makhetlo a 5-6 ka letsatsi.

Nako ea kalafo ha e sa feta libeke tse peli (tšoaetso ea chlamydial e hloka kalafo e telele - ho tloha libeke tse 4 ho isa ho tse 5).

Litaelo tse khethehileng

Ofloxacin ha se lithethefatsi tsa khetho bakeng sa pneumonia e bakoang ke pneumococci. Ha e reretsoe kalafo ea li-tonsillitis tse matla.

Nakong ea kalafo, mahlaseli a letsatsi a tobileng le mahlaseli a UV (libethe tsa ho fifala, mabone a mercury-quartz) a lokela ho qojoa.

Ho feta likhoeli tse peli ho sebelisa moriana ona ha ho khothalletsoe.

Ha ho etsahalloa ke lintho tse kulang le litlamorao tse tsoang ho tsamaiso ea methapo e bohareng, Ofloxacin e lokela ho emisoa. Ka colse ea pseudomembranous e tiisitsoeng, tsamaiso ea molomo ea metronidazole le vancomycin e khothalelitsoe.

Haeba matšoao a tendonitis a hlaha, kalafo e lokela ho emisoa hang-hang, ka mor'a moo tendon ea Achilles e lokela ho emisoa mme ngaka e buoang ea methapo e buisane.

Basali ha ba khothalletsoe ho sebelisa li-tampon tse joalo ka li-tampons nakong ea phekolo ea lithethefatsi, kaha ho na le kotsi e kholo ea ho holisa candidiasis ea vaginal.

Nakong ea ts'ebeliso ea Ofloxacin, litlamorao tse mpe tse mpe li ka etsahala ka mokhoa oa baktheria bakeng sa tlhahlobo ea lefuba.

Ho bakuli ba reriloeng nakong ea kalafo le lithethefatsi, ho ka etsahala hore litlhaselo tsa porphyria khafetsa le ho mpefala ha nako ea myasthenia li etsahale.

Ho bakuli ba nang le bothata ba ho ruruha ba mokokotlo kapa bo amanang le hepatic, khatello ea plasma ea ofloxacin e lokela ho betoa leihlo. Ka ho hlohlona ho matla ha hepatic kapa renal, menyetla ea ho ba le litlamorao e le mpe.

Nakong ea kalafo, joala bo lokela ho qojoa.

Bongoaneng, Ofloxacin e sebelisoa feela maemong ao ho nang le ts'okelo ea bophelo 'me ho ke ke ha khoneha ho sebelisa tse ling, tse se nang chefo tse ngata. Tabeng ena, tekanyo ea melemo e lebelletsoeng le kotsi e ka bang teng ea litlamorao e lokela ho nahanoa.

Nakong ea kalafo, hoa hlokahala ho hana ho etsa lintho tse ka bang kotsi le ho khanna.

Nakong ea ts'ebeliso ea mafura a Ofloxacin, lilense tse bonolo tsa ho ikopanya ha lia lokela ho apesoa. Ka lebaka la nts'etsopele ea photophobia, ho khothaletsoa ho sebelisa likhalase le ho qoba ho chaba nako e telele.

Mafura ha a kenngoe ka kamoreng e ka ntle ea leihlo kapa subconjunctivally.

Ho sebelisana le lithethefatsi

Ofloxacin e eketsa khatello ea glibenclamide ho plasma ea mali, e fokotsa tumello ea theophylline ka 25%.

Tubular secretion e thibelang lithethefatsi, furosemide, cimetidine le methotrexate li eketsa bongata ba plasma ea ofloxacin.

Ka tšebeliso e tšoanang ea methylxanthine le li-derivatives tsa nitroimidazole, le lithethefatsi tse seng tsa antiidalidal, menyetla ea ho ba le litlamorao tsa neurotoxic ea eketseha.

Ha e kopantsoe le glucocorticosteroids, kotsi ea nts'etsopele ea tendon e eketseha, haholoholo ho batho ba baholo.

Li-citrate, li-inhibitors tsa carbonic anhydrase le sodium bicarbonate li eketsa kotsi ea litlamorao tsa nephrotoxic le crystalluria.

Ka tsamaiso e ts'oanang le bahanyetsi ba antioxidant ba sa tobang ba vithamine K, ho hlokahala hore ho be le boemo ba tsamaiso ea methapo ea mali.

Tharollo ea Ofloxacin e lumellana le meriana ka tharollo ea Ringer, tharollo ea 5% tsoekere (dextrose), tharollo ea isotonic NaCl le tharollo ea 5% ea fructose.

Ha u sebelisa lithethefatsi ka mokhoa oa setlolo ka nako e le ngoe le litlolo tse ling tsa mahlo / marotholi, ho lokela ho shejoe nako e itseng bonyane metsotso e 15, ha Ofloxacin e sebelisoa qetellong.

Sebopeho le mofuta oa tokollo

Ofloxacin ke ntho e sebetsang ealoxacin, setlhare se hlahisoa ka mokhoa oa:

1. Tharollo e etselitsoeng infusion, 'mala o hlakileng o botala bo bosehla, ho 1 ml e nang le 2 mg ea motsoako o ka sehloohong. Lintho tse ling ke: sodium chloride, disodium edetate dihydrate, hydrochloric acid e kenelletseng, metsi d / le. Setlhare sena se rekisoa ka tekanyetso ea 100 ml ka li-vials tsa khalase tse se nang mebala,
2. Letlapa, le koahetsoeng ka filimi e tšoeu, biconvex ho pota, le litaba tsa ofloxacin ka tekanyetso ea 400 kapa 200 mg. Lisebelisoa tse thusang: poloxamer, starch ea poone, crospovidone, magnesium stearate, talc, lactose monohydrate, povidone. Moetso oa khetla o kenyelletsa: titanium dioxide, macrogol, talc, hypromellose. E rekisoa ka matlapa a 10 kapa a 7 lipaketeng tsa sele, e leng lipapatso tsa contour. 1 kapa lipakete tse 2 ka lebokoseng la lebokose.

Sehlopha sa Clinical le pharmacological: sethethefatsi sa antibacterial sa sehlopha sa fluoroquinolone.

Hobaneng ha Ofloxin a laetsoe?

Ofloxin e ipakile e le kalafong ea:

• tšoaetso ea masapo le manonyeletso,
• lisele tse bonolo le letlalo,
• tšoaetso ea liphio (pyelonephritis),
• ts'oaetso ea pampitšana ea urinary (urethritis, cystitis),
• meningitis
• chlamydia
• Mafu a amanang le AIDS
• ts'oaetso ea litho tsa kahare tsa mpa (endometritis, salpingitis, cervicitis, parametritis, prostatitis),
• ts'oaetso e mpe ea liphatsa tsa botšehali (orchitis, colpitis, epididymitis, gonorrhea, prostatitis),
• mafu a tšoaetsanoang le a tšoaetsanoang a litho tsa ka mpeng: (ts'oaetso ea sefuba sa ka mpeng, mokhoa oa biliary / ntle le baktheria enteritis /),
• tšoaetso e matla ea phepelo ea ("bronchiectasis, abscess" ea matšoafo, pneumonia),
• ts'oaetso ea litho tsa ENT (atitis media, sinusitis, pharyngitis, laryngitis / ntle le li-tonsillitis tse mpe haholo),
• tšoaetso ea mahlo (conjunctivitis, ulcers ea 'mele ea baktheria, blepharitis, dacryocystitis, meibomite, keratitis).

Ofloxin e sebelisoa hape ka mafolofolo:

• thibelong ea mathata a tšoaetsanoang ka mor'a ho buuoa mabapi le ho tlosoa ha 'mele o lemetseng kapa likotsi tsa mahlo,
• ka kalafo e rarahaneng ea lefuba,
• ts'ebetsong ea ts'oaetso ea tšoaetso ho bakuli ba nang le immunodeficiency (neutropenia).

Foromo ea litekanyetso

200 mg, 400 mg, matlapa a koahetsoeng ka filimi

Letlapa le leng le na le

ntho e sebetsang - ofloxacin 200 mg, 400 mg,

Baeti: litapole starch, lactose monohydrate, cellcose ea microcrystalline, povidone K30, sodium starch glycolate, magnesium kapa calcium stearate, calcium carboxymethyl cellulose

Ho hlophisoa ha khetla: polyethylene glycol 6000, titanium dioxide (E 171), hypromellose 2910.

Matlapa a koahetsoeng, ho tloha ho 'mala o mosoeu ho ea ho tranelate ka' mala, sebopeho sa capsule, se nang le letšoao le mongolo, ka lehlakoreng le leng likotsi ke lengolo "G", ka lehlakoreng le leng - palo "200" - bakeng sa litekanyetso tsa 200 mg.

Matlapa a koahetsoeng, ho tloha ho 'mala o mosoeu ho ea ho tranelate ka' mala, sebopeho sa capsule, se nang le letšoao le mongolo, ka lehlakoreng le leng likotsi ke lengolo "G", ka lehlakoreng le leng - palo "400" bakeng sa litekanyetso tsa 400 mg.

Melemo ea pharmacological

Mofumahali

Ho kenella ka mor'a ho kenella ho potlakile ebile ho phethehile. Palo e phahameng ea plasma ea mali e fihlella ka nako ea lihora tse 1-3 kamora tekanyetso e le 'ngoe ea 200 mg. Ho felisoa ha halofo ea bophelo ke lihora tse 4-6 (ho sa natsoe lethalamo).

Ka ho se sebetse hantle ke moriana o nooang o lokela ho fokotsoa.

Ha ho na tšebelisano-kholo ea bohlokoa ea lijo e fumanoeng.

Pharadodynamics

Ofloxacin ke lithethefatsi tse thibelang likokoana-hloko tsa sehlopha sa quinolone, se nang le litlamorao tsa bactericidal. Mochine o ka sehloohong oa ts'ebetso ke ho thibeloa ka ho khetheha ha "bacteric" encyme ea enzayone. Enzyme ea DNA e na le tšusumetso e pheta-phetang ea DNA, ho e ngola, ho e lokisa le ho e kopanya hape. Ho thibeloa ha enzyme ea DNA ho lebisa ho otlolliseng le ho tsitsiseng ha libaktheria tsa DNA 'me ho baka lefu la lisele tsa libaktheria.

Sekhahla sa antibacterial sa ho hlasimoloha ha likokoana-hloko ho ofloxacin.

Likokoana-hloko tse utloang ka ho fetisisang: Staphylococcusaureus(ho kenyeletsoa le methicillin)Staphylococci),Staphylococcusepidermidis,Neisseriamefuta,Esherichiacoli,Citrobempacter,Klebsiella,Enterobacter,Hafnia,Proteus(ho kenyelletsa botle le ho se sebetse hantle ka indole),Haemophilusntaramane,Chlamydie,Legionella,Gardnerella.

Likokoana-hloko tse nang le kutloisiso e fapaneng ea ealoxacin: Streptococci,Serratiamarcescens,PseudomonasaeruginosaleMycoplasmas.

Metsoalo e hanyetsang (e sa tsotelleng) ea ofloxacin: mohlala Libaktheriamefuta,Eubacteriummefuta,Fusobacteriummefuta,Peptococci,Peptostreptococci.

Tekanyetso le tsamaiso

Ofloxacin e lokela ho khethoa motheong oa lithuto tsa likokoana-hloko le tlhahlobo ea kutloisiso ea likokoana-hloko.

Litekanyetso li itšetlehile ka mofuta le tšoaetso ea ts'oaetso, hammoho le kutloisiso ea likokoana-hloko le tšebetso ea sebete le ea liphio.

Bakeng sa bakuli ba baholo, tekanyo ea lithethefatsi ke 200 - 800 mg ka letsatsi.

Tekanyetso ea ho fihlela ho 400 mg ka letsatsi e ka khethoa tekanyetso e le 'ngoe, hamolemo hoseng, litekanyetso tse phahameng li lokela ho aroloa ka litekanyetso tse peli. Ka kakaretso, litekanyetso tsa motho ka mong li lokela ho nkuoa ka linako tse lekanang.

Tšoaetso e tlase ea mofets'e

Litekanyetso tse tloaelehileng tsa motho ka mong ke ts'oaetso ea pampiri ea urinary ea 200 mg ho isa ho 400

Litekanyetso tse tloaelehileng tsa motho ka mong ke 400 mg ofloxacin ka letsatsi, e eketseha ho 400 mg habeli ka letsatsi, haeba ho hlokahala.

Tšoaetso e tlase ea phefumoloho

Pilisi e tloaelehileng ea motho ka mong ke 200 ho 400 mg ealoxacin ka letsatsi, e eketseha ho 400 mg habeli ka letsatsi, haeba ho hlokahala.

Lehlohlojane le sa phekoleheng la mokokotlo le sa phekoleheng

Tekanyetso e le 'ngoe ea 400 mg.

Urethritis e se nang neococcal le cervicitis

Tekanyetso e le 'ngoe ea 400 mg, e ka arohanngoang ka litekanyetso tse peli.

Mafu a tšoaetsanoang ke letlalo le lisele tse bonolo

Litekanyetso tse tloaelehileng tsa motho ka mong ke 400 mg ofloxacin habeli ka letsatsi.

Bakuli ba nang le ts'oaetso ea renal

Bakeng sa bakuli ba nang le ts'ebetso ea renal e sa sebetseng hantle, tekanyetso e bontšitsoeng tafoleng e ka tlase e khothalletsoa:

Tekanyetso e le 'ngoe, mg *

Khafetsa ea ho noha moriana ka letsatsi

Nako e pakeng tsa ho amoheloa, h

Ha ho na tokiso ea tekanyetso e hlokahalang

50 - 20 di ml / min (serum creatinine 1.5-5.0 mg / dl)

Ketso ea pharmacological

Lithethefatsi tsa antimicrobial fluoroquinolone Ofloxin ke pono e pharalletseng, matlapa a na le phello ea bactericidal, ke hore, e lebisa lefung la libaktheria tsa pathogenic. Ke tla fana ka lethathamo la hore na litokisetso tsa limela tse sebetsang li sebetsa ka tsela e feng: Salmonella spp, Brucella spp, Chlamydia spp, Yersinia enterocolitica, Enterococcus faecalis, Proteus spp, Vibrio cholerae, Serratia marcescens, Haemophiluseronfesserfesserenderitequentierendereferosmeliporiferafomerisafeloerenderemereseoqueresaquisarequisaresentiressafekethohofereferaheloo. Campylobacter jejuni, Aeromonas hydrophila, Bordetella pertussis.

Ntle le moo, lithethefatsi li nka libaktheria tse joalo: Staphylococcus aureus, Citrobacter spp, Gardnerella vaginalis, Mycobacterium lefuba, Mycoplasma pneumoniae, Staphylococcus epidermidis, Streptococcus pyogene, Mycoplasma hominis, Acinetobacter sppxlera , Neisseria meningitidis, Escherichia coli, Clostridium perfringens, Bordetella parapertussis, Listeria monocytogene, Shigella spp, Helicobacter pylori, Ureaplasma urealyticum, Vibrio parahaemolyticus, Haemophilus influenzae, Hafnia spp.

Kamora ho nka Ofloxin, e ananeloa ke 95%, hoo e ka bang liperesente tse tšoanang ke lithethefatsi tsa bioavailability. Protein e tlamang ke 25%. Ofloxacin e kenella ka har'a maro a mang a 'mele, hammoho le liseleng tse ngata. Ha e bokelle (ha e bokelle). Bophelo ba halofo ea lithethefatsi bo nka lihora tse supileng. E etselitsoe sebeteng. Ha e fetohe, e pepesitsoe ka har'a moroto.

Taeo ea tharollo

Litekanyetso tsa "orloxacin" li khethoa ka bonngoe ke ngaka e eang, ho latela boima ba lefu lena le mofuta oa moemeli ea tšoaetsanoang.

Ofloxacin bakeng sa infusion: tekanyetso e le 'ngoe ea 200-400 mg (libotlolo tse peli) 2 r / s nako le nako ea lihora tse 12 (bakeng sa batho ba baholo ba nang le ts'ebetso ea renal renal. Ka ho se sebetse hantle ke lefutso, ha tumello ea "creatinine" e feta 50 ml / min, ha ho hloke phetoho ea lethal dose. Ka tumello ea 20-50 ml / min, 200 mg e sebelisoa ka tekanyetso ea ho qala, ebe 100 mg / ka letsatsi. Ka lengolo la tumello e ka tlase ho 20 ml / min, sebelisa lethal dose ea ho qala ea 200 mg, ebe 100 mg hang ka matsatsi a mabeli. Ka ho hloleha ha sebete, lethal dose ha le fetele 400 mg / letsatsi. Tharollo ea infusion e tsamaisoa ka mokhoa o kenang kahare halofo ea hora.

Ka ntlafatso maemong a akaretsang le karabelo e ntle ea moriana, infusion e nkeloa sebaka ke e 'ngoe ea kahare ka tekanyetso e le' ngoe. Nako ea kalafo ke matsatsi a 7-10.

Bokhachane le pelehi

Ts'ebeliso ea lithethefatsi Ofloxacin nakong ea kemolo e hanyetsitsoe.

Hobane Hobane forloxacin e fetela lebese la matsoele, tšebeliso ea Ofloxacin Zentiva e tšoaelitsoe mabapi le kotsi e ka bang teng ho lesea. Haeba ho hlokahala, ts'ebeliso ea eona e lokela ho nka qeto mabapi le ho felisoa ha letsoele.

Tšebelisano ea lithethefatsi

Ofloxacin e kenella le ho feta ha e jeoa lijong tse nang le calcium e ngata, potasiamo le magnesium. Ka hona, pakeng tsa ho ja ka lintho tsena le moriana o lokela ho nka lihora tse peli.

Lithethefatsi tse thibelang secretion ea tubular, hammoho le Ofloxin, li eketsa bongata ba ntho ea mantlha ho plasma. Ka hona, ts'ebeliso ea lichelete tse joalo e lokela ho tšoaroa ka hloko. Ofloxin 200 e kopantsoeng le vithamine K e na le phello e mpe mokhoeng oa mali.

Se ke oa nka moriana ka nako e le ngoe le moroto oa alkalizing. Sena se ka lebisa ho crystallization le litlamorao tsa nephrotoxic.

Ofloxin analogue

Analogue ea sebopeho sa ntho e sebetsang:

• Vero Ofloxacin,
• Glaufos,
• Danzil
• Zanocin,
• Zoflox,
• Hangata,
• Oflox
• Ofloxabol,
• Ofloxacin
• Ofloxin 200,
• Oflomac,
• Oflocid,
• Oflocide Forte
• Tarivid
• Tariferide
• Taritsin,
• Uniflox
• Phloxal.

Tlhokomeliso: ts'ebeliso ea li-analogues e lokela ho lumellana le ngaka e eang.

Theko e tloaelehileng ea OFLOXACIN, matlapa a litlhare (Moscow) li-ruble tse 200.

Maemo a polokelo

Boloka nako e sa feteng lilemo tse 3 sebakeng se omileng, hole le khanya, ka mocheso oa 10-25 ° C. Tharollo ea infusion e thibetsoe ka matla hore e se ke ea chesa.

Nka ba ka re ke tšoeroe ke cystitis e sa foleng ho tloha bocheng ba ka, ka hona, ke se ke ntse ke tseba lipholiso tsohle tsa cystitis. Empa ofloxin o ile a nkopa ngaka ke urologist feela likhoeling tse 'ne tse fetileng mme a e khothaletsa hore ke setlhare se matla haholo se sebetsang. Ho joalo, ke ile ka feta kalafong eohle e behiloeng ea kalafo, empa ho pholletsa le nako eohle ke ikutloa ke sa khotsofala, ke bile le phetoho ea tatso, lijo tsohle li latsoeha joalo ka tjhoko, ka hona ha ho na monyetla oa ho sebelisa pheko ena.

Setlhare se setle. Ke noele ho tsoa ho prostatitis, ho bile bonolo makhetlo a 'maloa, ebe feela ka phello e bonolo e bonolo e tsitsitseng. Ebile, ha ts'oaetso e bolaoa, joale tšoaetso e tloha kapele.

Bala bonyane litaelo tsa smartprost! Ha a lokise letho!

Hobaneng ha litsebi tsa urology li re bohlale bo bonolo ho thibela mafu a feteletseng?