Flemoklav Solutab - litaelo tsa semmuso bakeng sa tšebeliso
Flemoklav Solutab 875 + 125 mg - sethethefatsi se tsoang sehlopheng sa penicillin se nang le ts'ebetso e mengata. Litokisetso tse kopaneng tsa amoxicillin le clavulanic acid, inhibitor ea beta-lactamase.
Letlapa le leng le na le:
- Motsoako o sebetsang: amoxicillin trihydrate (e lumellanang le msingi oa amoxicillin) - 1019.8 mg (875.0 mg), potasiamo clavulanate (e tsamaellanang le clavulanic acid) - 148,9 mg (125 mg).
- Baeti: cellulose e qhalakantsoeng - 30,4 mg, cellcrystalline cellulose - 125,9 mg, crospovidone - 64.0 mg, vanillin - 1,0 mg, tatso ea tangerine - 9.0 mg, tatso ea lemone - 11.0 mg, saccharin - 13.0 mg; magnesium stearate - 6.0 mg.
Tsamaiso
Hoo e ka bang 25% ea clavulanic acid le 18% ea amplillin ea plasma li amahanngoa le liprotheine tsa plasma. Bophahamo ba karolelano ea amoxicillin ke 0,3 - 0,4 l / kg mme boholo ba kabo ea clavulanic acid ke 0,2 l / kg.
Kamora taolo ea methapo, amoxicillin le clavulanic acid li fumanoa mokokotlong oa nyooko, mokokotlong oa mpa, letlalo, mafura le mesifa ea mesifa, metsing a pakeng tsa mokokotlo le a peritoneal, hammoho le bile. Amoxicillin e fumanoa lebese la matsoele.
Amoxicillin le clavulanic acid li haola le tšitiso ea placental.
Biotransformation
Amoxicillin e qepha ka mokhoa o sa ts'oaneng le moroto ka mokhoa o sa sebetseng oa penicilloid acid, ka karolo ea 10-25% ea lethal dose la pele. Clavulanic asiti e tšeloa ka har'a sebete le liphio (e pepesitsoeng ka har'a moroto le makhopho) hammoho le khabone e nang le moea o mongata.
Bophelo ba halofo ea amoxicillin le clavulanic acid e tsoang ho serum ea mali ho bakuli ba nang le ts'ebetso e tloaelehileng ea menoana e ka ba hora e le 'ngoe (lihora tse 0,9-1,2), ho bakuli ba lumelloang ke tumellano ka har'a 10-30 ml / min ke lihora tse 6, mme ho latela anuria, ke pakeng tsa 10 le 15 lihora. Setlhare sena se hlakoloa nakong ea hemodialysis.
Hoo e ka bang 60-70% ea amoxicillin le 40-65% ea clavulanic acid ha e sa fetoloe ka moroto nakong ea lihora tse 6 tsa pele.
Matšoao a ho sebelisoa
Motsoako oa amoxicillin le clavulanic acid o bontšoa molemong oa kalafo ea tšoaetso ea baktheria ea libaka tse latelang tse bakoang ke likokoana-hloko tse amehang ka ho kopana ha amoxicillin le clavulanic acid:
- Likokoana-hloko tsa phepelo e phahameng ea ("ho kenyeletsa le ts'oaetso ea ENT), joalo ka" narillillillitis "sinusitis, media media, hangata e bakoang ke Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, le Streptococcus pyogenes.
- Ts'oaetso e tlase ea phefumoloho, joalo ka ho ata ha bronchitis e sa foleng, lobar pneumonia le bronchopneumonia, e atisang ho bakoa ke Streptococcus pneumoniae, Haemophilus influenzae, le Moraxella catarrhalis.
- Tšoaetso ea pampitšana ea Urogenital, joalo ka cystitis, urethritis, pyelonephritis, ts'oaetso ea basali, hangata e bakoang ke mefuta ea lelapa la Enterobacteriaceae (haholo-holo Escherichia coli), Staphylococcus saprophyticus le mefuta ea mofuta oa genoc Enterococcus, le gonorrhea e bakoang ke Neisseria gonorrhoeae.
- Tšoaetso ea letlalo le lisele tse bonolo, hangata li bakoa ke Staphylococcus aureus, Streptococcus pyogene, le mefuta ea mofuta oa Bacteroides.
- Tšoaetso ea masapo le manonyeletso, mohlala, osteomyelitis, hangata e bakoang ke Staphylococcus aureus, haeba ho hlokahala, kalafo ea nako e telele e ka khonahala.
- Ts'oaetso ea Odontogenic, ka mohlala, periodontitis, odontogenic maxillary sinusitis, li-abscesses tse matla tsa meno le ho ata ha cellulitis.
- Mafu a mang a kopaneng (jk. Ho ntša mpa ka septic, sepsis ea morao-rao, intra-abdominal sepsis) e le karolo ea kalafo ea mohato.
Ts'oaetso e bakoang ke likokoana-hloko tse anngoeng ke amoxicillin e ka alafshoa ka Flemoklav Solutab®, kaha amoxicillin ke e 'ngoe ea metsoako ea eona e sebetsang. Flemoklav Solutab® e bonts'oa hape bakeng sa kalafo ea ts'oaetso e kopaneng e bakoang ke likokoana-hloko tse utloang haholo ka amoxicillin, hammoho le likokoana-hloko tse hlahisang beta-lactamase, e tsotellang ho kopana ha amoxicillin le clavulanic acid.
Boikutlo ba libaktheria ho kopantsoeng ea amoxicillin le acid ea clavulanic bo fapana ho ea ka sebaka le nako e telele. Moo ho khonehang, datha ea sensitivity ea lehae e lokela ho tsotelloa. Haeba ho hlokahala, mehlala ea likokoana-hloko e lokela ho bokelloa le ho hlahlojoa bakeng sa kutloisiso ea baktheria.
Contraindication
Moriana o ka nooa feela ka mor'a ho buisana le ngaka le ho etsa liteko. Tšebeliso e ikemetseng ea matlapa a moriana ntle le tlhahlobo e ka ts'oants'a setšoantšo sa lefu le ho etsa hore ho be thata ho etsa tlhahlobo e nepahetseng.
Matlapa a Flemoklav Solutab 875 + 125 mg a na le li-contraindication tse latelang bakeng sa ts'ebeliso:
- Hypersensitivity ho amoxicillin, clavulanic acid, likarolo tse ling tsa lithethefatsi, lithibela-mafu tsa beta-lactam (mohlala, penicillins, cephalosporins) ho anamnesis,
- likarolo tse fetileng tsa jaundice kapa ts'ebetso ea sebete e sa sebetseng ha u sebelisa motsoako oa amoxicillin le clavulanic acid historing
- bana ba ka tlase ho lilemo tse 12 kapa boima ba 'mele bo ka tlase ho 40 kg,
- ts'ebetso e sa sebetseng ea renal (clearinine clearance ≤ 30 ml / min).
Ka hlokolosi e kholo, lithethefatsi maemong a latelang:
- Ho hloleha ho matla ha sebete,
- mafu a pampitšana ea ka mpeng (ho kenyelletsa nalane ea colitis e amanang le ts'ebeliso ea penicillin),
- ho se sebetse hantle hantle ha renal.
Tekanyetso le tsamaiso
Ho thibela matšoao a dyspeptic, Flemoklav Solutab® e laetsoe qalong ea lijo. Letlapa le metsoa kaofela, le hlatsuoa ka khalase ea metsi, kapa le qhibilihile ka halofo ea khalase ea metsi (bonyane 30 ml), le hlohlelletsa hantle pele le sebelisoa.
Bakeng sa tsamaiso ea molomo.
Mokhoa oa ho fokotsa litekanyetso o beoa ka bonngoe ho latela lilemo, boima ba 'mele, ts'ebetso ea liphio tsa mokuli, le botebo ba ts'oaetso.
Phekolo ha ea lokela ho tsoela pele matsatsi a fetang 14 ntle le ho hlahloba maemo a kliniki.
Haeba ho hlokahala, ho ka etsahala ho etsa kalafo ea methapo (taolo ea pele ea methapo ea lithethefatsi ka phetoho e latelang ho tsamaiso ea molomo).
Ts'ebetso ea mokokotlo e sa sebetseng
Matlapa a 875 + 125 mg a lokela ho sebelisoa feela ho bakuli ba nang le tumello ea "creatinine" e fetang 30 ml / min, ha ho hlokahala hore ho sebelisoe litekanyetso tsa litekanyetso.
Maemong a mangata, haeba ho khonahala, phekolo ea batsoali e lokela ho khethoa. Ho bakuli ba nang le bothata ba ho sebetsa ha renal, ho tsitsipana ho ka hlaha.
Boimana
Thutong ea mosebetsi oa ho ikatisa ho liphoofolo, tsamaiso ea molomo le ea botsoali ea amoxicillin + clavulanic acid ha ea ka ea baka litlamorao tsa teratogenic.
Phuputsong e le 'ngoe ho basali ba nang le ho phatloha kapele ho litho tsa' mele, ho fumanoe hore kalafo ea lithethefatsi tsa prophylactic e ka amahanngoa le kotsi e eketsehang ea necrotizing enterocolitis ho masea a sa tsoa hlaha. Joalo ka litlhare tsohle, Flemoklav Solutab® ha e khothalletsoe ho sebelisoa nakong ea kemaro, ntle leha phaello e lebelletsoeng ho mme e feta kotsi e ka bang teng ho lesea.
Nako ea ho anyesa
Flemoklav Solutab e ka sebelisoa nakong ea ho anyesa. Ntle le monyetla oa ho susumetsa maikutlo, lets'ollo, kapa candidiasis ea mucous membrous ea molomo e amanang le ho kenella ha lipalo tsa litekanyetso tsa metsoako e sebetsang ea sehlahisoa sena ka lebeseng la matsoele, ha ho litla-morao tse ling tse ileng tsa bonoa ho masea a anyesitsoeng. Ha ho e-ba le litlamorao tse mpe ho masea a anyesitsoeng, ho anyesa ho lokela ho emisoe.
Litlamorao
Nakong ea ho nka litafole tsa Flemoklav Solutab ho bakuli ba nang le hypersensitivity ho lithethefatsi, litla-morao li ka hlaha:
- ho tsoa ho litho tsa hemopoietic - thrombocytosis, leukopenia, anemia, thrombocytopenia, agranulocytosis, keketseho ea nako ea prothrombin,
- ho tsoa ho lijo tsa ka mpeng - bohloko ba ka mpeng, ho nyekeloa ke pelo, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, enterocolitis, pseudomembranous colitis, sebete se holisitsoeng, dysbiosis ea mokokotlo, nts'etsopele ea ho hloleha ha sebete,
- ho tsoa ho ts'ebetso ea methapo - ho tsitsipana, khatello ea maikutlo, ho tsekela, ho teneha, ho ferekana kelellong, ho ferekanya boroko, ho ba mabifi,
- ho tsoa ka hara tsamaiso ea urine - ho ruruha lesapo la mokokotlo, ho ruruha habohloko, nephritis e kahare, ho chesa le ho hlohlona ka hara mpa ea basali.
- karohano ea mmele (allergic reaction) - lekhopho la letlalo, exanthema, urticaria, dermatitis, feberu ea lithethefatsi, ho ts'oaroa ke anaphylactic, lefu la serum,
- nts'etsopele ea bonohe.
Haeba litla-morao tse ling li hlaha, o lokela ho botsa ngaka bakeng sa likeletso; o kanna oa tlameha ho emisa kalafo ka moriana.
Bongata
Matšoao a tsoang mokokotlong oa mokokotlo le ho tsitsinyeha ho lekantsoeng la motlakase oa metsi a ka bonoa. Crystalluria ea Amoxicillin e 'nile ea hlalosoa, maemong a mang e lebisang ho nts'etsopele ea ho se sebetse hantle haholo (bona karolo "Litaelo tse Ikhethileng le Litšireletso").
Ho feto-fetoha ha maikutlo ho ka hlaha ho bakuli ba nang le ts'ebetso ea ho ruruha e sa sebetseng, hammoho le ho ba fumanang litekanyetso tse phahameng tsa lithethefatsi (bona karolo "Litekanyetso le Tsamaiso" - Bakuli ba nang le ts'oaetso ea renal, "Litla-morao".
Matšoao a tsoang liphatseng tsa ka mpeng ke kalafo ea matšoao, ho ela hloko ka ho khetheha ho fetisa botsitso ba motlakase oa metsi. Amoxicillin le clavulanic acid li ka tlosoa maling le hemodialysis.
Liphetho tsa boithuto bo lebelletsoeng bo entsoeng le bana ba 51 setsing sa chefo li bonts'itse hore tsamaiso ea amoxicillin ka tekanyo e ka tlase ho 250 mg / kg ha e ea ka ea baka matšoao a bohlokoa a kliniki mme ha e hloke ho hlaseloa ka mpeng.
Ho sebelisana ha sethethefatsi le lithethefatsi tse ling
Ka tsamaiso e tšoanang ea lithethefatsi ka Acetylsalicylic acid kapa Indomethacin, bolelele ba nako eo Amoxicillin e lulang maling le bile e eketseha, e leng se eketsang kotsi ea litlamorao.
Ka tšebeliso e tšoanang ea litafole tsa Flemoklav, solutab e nang le li-antacids, li-laxatives kapa aminoglycosides e fokotsa ho monya Amoxicillin 'meleng, ka lebaka leo phello ea kalafo ea lithibela-mafu e ke keng ea lekana.
Litokisetso tsa Ascorbic acid, ho fapana le moo, li eketsa ho monya Amoxicillin 'meleng.
Ka tsamaiso e tšoanang ea litafole tsa Flemoklav tse nang le Allopurinol, kotsi ea makhopho a letlalo e eketseha.
Ka tšebelisano ea lithethefatsi Flemoklav Solutab ka li-anticoagulants tse sa tobang, mokuli o na le monyetla o mong oa ho tsoa mali.
Maemong a mang, tlasa ts'usumetso ea lithethefatsi, katleho ea lithibela-pelehi tsa molomo e ea fokotseha, ka hona, basali ba khethang mofuta ona oa ts'ireletso khahlanong le moimana o sa batleheng ba lokela ho ba hlokolosi 'me ba sebelise lithibelo tsa thibelo ea bokhachane nakong ea kalafo.
Litaelo tse khethehileng
Bakuli ba tloaetse ho tšoaroa ke lithethefatsi pele ba sebelisa Flemoklav solutab, ho bohlokoa ho etsa tlhahlobo ea maikutlo, hobane penicillins hangata e baka ho kula ho tebileng. Ka nts'etsopele ea matšoao a anaphylaxis kapa angioedema, moriana o felisoa hanghang mme o sheba ngaka.
U ke ke ua emisa kalafo ka boithaopo hang hang ha ntlafatso ea pele maemong e se e hlahile. Hoa hlokahala hore u noe thuto e boletsoeng ke ngaka ho fihlela qetellong. Ho kenella kalafo pele ho nako ho ka lebisa ho hola ha likokoana-hloko ho Amoxicillin le phetoho ea lefu lena molemong oa thuto. Ha ho kgothaletswe ho nka matlapa a nako e telele ho feta nako e behiloeng (ha ho feta libeke tse 2), hobane maemong ana menyetla ea ho ba le bonohe le ho mpefala ha matšoao ohle a lefu lena a eketseha. Ha ho na le phello ea kalafo ea moriana nakong ea matsatsi a 3-5 ho tloha ho qala kalafo, mokuli o hloka ka potlako ho bona ngaka ho hlakisa tlhahlobo le ho lokisa kalafo e boletsoeng.
Haeba letšollo le sa khaotseng le hlaha nakong ea ts'ebetso ea moriana le ho kuta bohloko ba ka mpeng, kalafo e lokela ho emisoa hanghang mme ho buisanoe le ngaka, e leng se ka bakang pseudomembranous colitis.
Bakuli ba nang le mafu a sebete a sa foleng ba lokela ho ba hlokolosi haholo ha ba sebelisa Flemoklav Solutab, hobane tlasa ts'usumetso ea lithibela-mafu, boemo le ts'ebetso ea setho e ka mpefala.
Nakong ea phekolo ea lithethefatsi, ho lokela ho ba hlokolosi ha u khanna koloi kapa lisebelisoa tse hlokang karabelo e potlakileng. Sena se bakoa ke taba ea hore nakong ea kalafo, bakuli ba ka ba le ho ts'oaroa ka tšohanyetso.
Matlapa a 7 ka blister, lilomo tse peli hammoho le litaelo tsa tšebeliso li behiloe ka lebokoseng la karete.
Lipehelo tsa Khefu ea Litlama
Analogs ea lithethefatsi Flemoklav Solutab 875 + 125 ke bohato ba pharmacological ke:
- Matlapa a Augmentin le phofo bakeng sa ho emisoa
- Amoxiclav
- Amoxicillin
- Flemoxin
Lifekthering tsa bophelo bo botle ba lithethefatsi Moscow, theko e tloaelehileng ea matlapa a Flemoklav Solutab 875 + 125 mg ke li-ruble tse 390. (Li-pcs tse 14).
Foromo ea boholo:
Letlapa le leng le na le:
Lintho tse sebetsang: amoticillin trihydrate (e lumellanang le msingi oa amoxicillin) - 1019.8 mg (875.0 mg), potasiamo clavulanate (e tsamaellanang le clavulanic acid) -148.9 mg (125 mg).
Baeti: cellulose e qhalakaneng - 30,4 mg, cellcrystalline cellulose - 125.9 mg, crospovidone - 64.0 mg, vanillin - 1,0 mg, tatso ea tangerine - 9.0 mg, tatso ea lemone - 11.0 mg, saccharin - 13, 0 mg, magnesium stearate - 6.0 mg.
Matlapa a senyehang a mofuta oa oblong ho tloha ho o mosoeu ho ea ho o mosehla, ntle le likotsi, a tšoailoeng "425" le karolo e hlakileng ea letšoao la k'hamphani. Libaka tse sootho tsa brown li lumelloa.
Foromo ea litekanyetso
Matlapa a senyehang 875 mg + 125 mg
Letlapa le leng le na le
Lintho tse sebetsang: amoxicillin ka mokhoa oa amoxicillin trihydrate
- 875 mg, clavulanic acid ka mokhoa oa potasiamo clavulanate - 125 mg.
Baeti: cellulose e hlatsuoang, cellcose ea microcrystalline, crospovidone, vanillin, flavored mandarin, flavors ea Lemon, saccharin, stearate ea magnesium.
Matlapa a hasantsoeng ho tloha ho o mosoeu ho ea ho o moputsoa, o mosehla, o tšoailoeng "GBR 425" le karolo e hlakileng ea letšoao la k'hamphani. Libaka tse sootho tsa brown li lumelloa
Melemo ea pharmacological
Mofumahali
Ka botlalo bioavailability ea amoxicillin / clavulanic acid ke 70%. Ho chesa ha ho na boikemelo ba lijo. Kamora tekanyetso e le 'ngoe ea Flemoklav Solutab ka tekanyo ea 875 + 125 mg, kakaretso e phahameng ea amoxicillin ka plasma ea mali e thehiloe kamora hora ea 1, mme ke 12 μg / ml. Ho tlama liprotheine tsa Serum ke hoo e ka bang 17-20%. Amoxicillin e tšela sethala sa placental ebe e fetela lebese la matsoele ka tekanyo e nyane.
Tlhahiso e felletseng ea lintho tse peli tse sebetsang ke 25 l / h.
Hoo e ka bang 25% ea clavulanic acid le 18% ea amplillin ea plasma li amahanngoa le liprotheine tsa plasma. Bophahamo ba karolelano ea amoxicillin ke 0,3 - 0,4 l / kg mme bophahamo ba karolelano ea clavulanic acid ke 0,2 l / kg.
Kamora taolo ea methapo, amoxicillin le clavulanic acid e fumanoa ka har'a lesapo la nyooko, mokokotlo oa mpa, letlalo, mafura le mesifa ea mesifa, metsing a pakeng tsa mokokotlo le a peritoneal, hammoho le bile. Amoxicillin e fumanoa lebese la matsoele.
Amoxicillin le clavulanic acid li haola le tšitiso ea placental.
Amoxicillin e qepha ka mokhoa o sa ts'oaneng le moroto ka mokhoa o sa sebetseng oa penicilloid acid, ka karolo ea 10-25% ea lethal dose la pele. Clavulanic asiti e tšeloa ka har'a sebete le liphio (e hlohlellelitsoeng ka moroto le makhopho) hammoho le khabone ea khabone e nang le moea o felileng.
Bophelo ba halofo ea amoxicillin le clavulanic acid e tsoang ho serum ea mali ho bakuli ba nang le ts'ebetso e tloaelehileng ea fig re hoo e ka bang hora e le 'ngoe (lihora tse 0,9-1,2), ho bakuli ba nang le tumello ea creatinine kahare ho 10-30 ml / min ke lihora tse 6, mme maemong a anuria e fapana. pakeng tsa 10 le 15 lihora. Setlhare sena se hlakoloa nakong ea hemodialysis.
Hoo e ka bang 60-70% ea amoxicillin le 40-65% ea clavulanic acid ha e sa fetoloe ka moroto nakong ea lihora tse 6 tsa pele.
Pharadodynamics
Flemoklav Solutab® - lithibela-mafu tse pharalletseng, litokisetso tse kopaneng tsa amoxicillin le clavulanic acid - beta-lactamase inhibitor. E etsa bactericidal, e thibela ho hlophisoa ha lerako la baktheria. E sebetsa khahlano le likokoana-hloko tse mpe tsa gram le gram-negative (ho kenyeletsa le mefuta e hlahisang beta-lactamases). Asiti ea clavulanic acid eo e leng karolo ea mofuta oa beta-lactamase ea lithethefatsi, e sa sebetseng khahlano le mofuta oa beta-lactamase e hlahisitsoeng. Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid e na le tropism e phahameng bakeng sa penicillinases, ka lebaka leo e theha motsoako o tsitsitseng ka enzyme, e thibelang ho senyeha ha enzymatic ea amoxicillin tlasa tšusumetso ea beta-lactamases le ho atolosa boholo ba eona ba ketso.
Flemoklav Solutab® E sebetsa khahlanong le:
Baktheria e ntle ea gram: Streptococcus pyogene, virreans tsa Streptococcus, Streptococcus pneumoniae, Staphylococcus aureus (ho kenyelletsa likarolo tse hlahisang beta-lactamase), Staphylococcus epidermidis (ho kenyelletsa likarolo tse hlahisang beta-lactamase), Enterococcus faecalis, Corynebacterium spp. Bacillus anthracis, Listeria monocytogene,Gardnerellavaginalis
Libaktheria tse ntle tsa gram: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.
Libaktheria tse mpe tsa aerobic: Escherichia coli, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Yersinia enterocolitica, Salmonella spp., Shigella spp. (ho kenyeletsoa mefuta ea libaktheria tse kaholimo e hlahisang beta-lactamase), Neisseria meningitidis, Bordetella pertussis, Gardnerella vaginalis, Brucella spp., Branhamella catarrhalis, Pasteurella multocida, Campylobacter jejuni, Vibrio cholerae, Moraxella catarrhalis, Helicobacter pylori.
Libaktheria tse mpe tsa anaerobic: Bacteroides spp.ho kenyelletsa Bacteroides fragilis,Fusobacteriumspp (ho kenyeletsoa mefuta e hlahisang beta-lactamases).
Tekanyetso le tsamaiso
Ho thibela matšoao a dyspeptic, Flemoklav Solutab® e laetsoe qalong ea lijo. Letlapa le metsoa kaofela, le hlatsuoa ka khalase ea metsi, kapa le qhibilihile ka halofo ea khalase ea metsi (bonyane 30 ml), le hlohlelletsa hantle pele le sebelisoa.
Nako ea kalafo e itšetlehile ka boteng ba ts'oaetso mme ha ea lokela ho feta matsatsi a 14 ntle le tlhoko e khethehileng.
Batho ba baholo le bana ≥ 40 kg Flemoklav Solyutab® ka litekanyetso
875 mg / 125 mg e behiloe makhetlo a 2 ka letsatsi.
Ka tšoaetso ea pampiri e ka tlase ea ho hema kapa mecha ea litaba ea otitis, tšebeliso ea lithethefatsi e ka eketsoa makhetlo a 3 ka letsatsi.
Tekanyetso e le 'ngoe e nooa khafetsa, ka nako e' ngoe le e 'ngoe ka lihora tse 12.
Ho tloha ho 25 mg / 3.6 mg / kg / letsatsi ho isa ho 45 mg / 6.4 mg / kg / letsatsi habeli ka letsatsi.
Bakeng sa ts'oaetso ea ts'ebetso ea phefumoloho e tlase kapa media ea otitis, lethal dose le ka eketsoa ho 70 mg / 10 mg / kg / letsatsi, makhetlo a 2 ka letsatsi.
Ho bakuli ba nang le bothata ba ho renal bo holofetseng excretion ea clavulanic acid le amoxicillin ka liphio e ea fokola. Flemoklav Solutab® ka tekanyo ea 875 mg / 125 mg e ka sebelisoa feela ka tekanyo ea filtration ea glomerular> 30 ml / min.
Ho bakuli ba nang le ts'ebetso ea sebete e sa sebetseng Flemoklav Solyutab® e lokela ho khethoa ka tlhokomelo. Ts'ebetso ea sebete e lokela ho lula e beiloe leihlo.