Metabolic syndrome

E 'ngoe ea li-pathologies tse tloaelehileng le tse kotsi ho motho oa kajeno e se e bitsoa metabolic syndrome. Lingaka ha li hlahise boemo bona ka mafu a motho ka mong, ho fapana le moo, ke motsoako oa maloetse a mangata a tebileng a metabolic le tsamaiso ea methapo ea pelo. Pathology e atile lilemong tsa bohareng, haholoholo ho banna, empa kamora lilemo tse 50, metabolic syndrome e atile haholo ho basali. Sena se bakoa ke ho fokotseha ha tlhahiso ea estrogen ka nako ena. Haufinyane tjena, psychology e ntse e ata haholo, hoo e batlang e le kotara ea baahi ba linaha tse tsoetseng pele e na le lefu la metabolic. O ile a qala ho makatsa bana. Sena se bakoa ke bophelo ba ho lula fatše le ho ja lijo tse nang le lik'habohaedreite ho batho ba bangata.

Metabolic syndrome ho basali: ke eng

Psychology ena ha se lefu le arohaneng. Le metabolic syndrome e kenyelletsa ho kopanya maloetse ana a mane a tebileng:

• mofuta oa lefu la tsoekere
• khatello ea mali
• lefu la pelo
• botenya.

Mafu ana kaofela a tebile ka boeona, empa ha a kopane a fetoha kotsi le ho feta. Ka hona, lingaka li bitsa metabolic syndrome "quartet e bolaeang." Ntle le kalafo e lekaneng, hangata methapo ea kutlo e lebisa ho mathata a tebileng esita le lefu. Ka hona, ho bohlokoa haholo ho fumana lefu la metabolic ho basali ka nako. Seo se tsebahalang hangata ho basali nakong ea ho khaotsa ho ilela khoeli. Mme basali ba bangata ba amahanya ho kula ha bona le ho khaotsa ho ilela khoeli. Ka hona, ho botsoa ngaka e se ntse e le maemong a morao a nts'etsopele ea ts'ebetso ea methapo, ha liphetoho tsa ts'ebetso ea pelo li bonahala. Empa ka thuso ea kalafo e nang le bokhoni, ho sa ntse ho khonahala ho emisa tsoelo-pele ea mathata a bophelo bo botle. Le ha ho le joalo ho lumeloa hore pathology e ke ke ea phekoloa ka botlalo.

Metabolic syndrome ho basali: tlhaloso

Mofuta ona oa liphetoho maemong a bophelo bo botle o amahanngoa le mathata a metabolic. Oa mantlha ke nts'etsopele ea ho hloka matla ha lisele ho insulin. Ka lebaka leo, hormone ena e khaotsa ho etsa mesebetsi ea eona, mme glucose ha e huloe ke lisele. Sena se lebisa phetohong ea methapo ea litho tsohle, haholo-holo boko bo nang le mathata.

Mosebetsi o ka sehloohong oa insulin ke ho baka mochine oa ho tsamaisa tsoekere ka seleng. Empa haeba li-receptors tse kenyelletsang ho sena li lula li sa nahanele li-hormone tsena, ts'ebetso e ka senyeha. Ka lebaka leo, tsoekere ha e amoheloe, insulin e ntse e hlahisoa, 'me e bokellana maling.

Ntle le moo, metabolic syndrome ho basali e tšoauoa ka keketseho ea cholesterol "e mpe" le triglycerides ka lebaka la metabolism ea mafura a senyehileng. Ho boetse ho na le uric acid e ngata le ho se leka-lekane ha lihormone. Ka lebaka la liphetoho tsena, khatello ea mali ea phahama, botenya bo hlaha, mme mosebetsi oa pelo oa sitisoa.

Liphetoho tsena kaofela lia fetoha 'meleng butle butle. Ka hona, ho hang ha ho khonehe ho fumana kalafo ea metabolic ho basali. Matšoao a eona a fumanoa ha liphetoho li ama mosebetsi oa litho tse ngata. Empa pele, ka lebaka la khaello ea phepo e ntle le bophelo ba ho lula fatše, kutloisiso ea lisele tsa insulin e ea ferekana. Ka lebaka leo, manyeme a qala ho hlahisa le horoni ena e ngata ho fana ka glucose ho lisele. Lenane le leholo la insulin maling le baka mathata a metabolic, haholo-holo ts'ebetso ea ho monya mafura. Ho nona ho eketseha, khatello ea mali ea phahama. 'Me ho ba le tsoekere e ngata maling ho lebisa ho lefu la tsoekere, hammoho le tšenyeho ea seaparo sa protheine sa lisele, se bakang botsofaling pele ho nako.

Lisosa tsa lefu la metabolic ho basali

Liphetoho tsa pathological 'meleng o nang le lefu lena li amahanngoa le ho hloka matla ha lisele ho insulin. Ke ts'ebetso ena e bakang matšoao ohle a khethollang lefu la metabolic ho basali. Mabaka a ho hanyetsa insulin a ka fapana.

• Hangata, lefu la tsoekere le hlaha ka lebaka la tšebeliso e feteletseng ea lik'habohaedreite le lijo tse mafura. Ka lebaka leo, tsoekere e ngata le mafura a mangata li kena maling. Ha ba na nako ea ho silila ebile ba kenngoa liseleng. Ka hona, botena bo ea hlaha. Mme acid e mafura e baka liphetoho liseleng tse sitisang kutloisiso ea insulin.
• Ka mokhoa o makatsang, empa lijo tse nang le khalori e tlase le tsona li baka mathata a mmele. 'Mele o boloka lithane tsa adipose, li etsa hore tsoekere e sa tsoakoe hantle.
• Ho haelloa ke ts'ebetso ea 'mele ho baka ho theoha butle butle lits'ebetsong tsohle tsa metabolic. Haholo-holo ka lebaka la sena, ho kenngoa ha mafura, a kentsoeng ka har'a lithane tse kenang ka tlase le litho tsa ka hare, hoa senyeha.
• Ka linako tse ling lefu la metabolic ho basali le ka bakoa ke lefutso. Maemong ana, ka ho phela bophelo bo qalang ba bophelo bo botle kapa khaello ea phepo e nepahetseng, botena bo ata kapele.
• Lithethefatsi tse ling li ka baka insulin ea insulin. Tsena ke li-corticosteroids, lihomone tse matlafatsang tsa qoqotho, lithibela-pelehi tsa molomo le baemeli ba bang ba hypoglycemic.
• Ho sithabela khafetsa ha khatello ea kelello le khatello ea kelello ea nako e telele ho senya ts'ebetso ea tlhahiso ea li-hormone. Hangata hona ho bontšoa tlhahiso ea insulin le kutloisiso ea lisele ho eona.
• Ho senyeha ha Hormonal ho lebisa 'neteng ea hore metabolic syndrome ho basali ba menopausal hangata ea hlaha. Sena se bakoa ke ho fokotseha ha tlhahiso ea estrogen.
• Mathata a amanang le ho potoloha ha mali, khatello e phahameng ea mali kapa tlala ea moea ea oksijene e boetse e fokotsa kutloisiso ea lisele ho insulin.

Metabolism syndrome e bonahala joang?

Pathology e hlaha e sa hlathe koana le koana, lilemong tsa morao tjena e ntse e hlaha ka ho eketsehileng lilemong tsa bocha. Empa lipontšo tsa eona tse ngata ha li bonoe maemong a pele. Ka hona, bakuli hangata ba retelehela ho ngaka ha liphofu tse tebileng mosebetsing oa litho tsa ka hare le lits'ebetso li se li hlokometsoe. Motho a ka tseba joang ha nako e ntse e ea hore lefu la metabolic le hlaha ho basali? Matšoao a lefu la patsi a ka ba ka tsela e latelang:

• mokhathala, ho felloa ke matla, ho fokotseha tšebetso,
• ho phomola nako e telele, ho ba le moea o mobe le ho ba mabifi,
• Kamehla ke batla lipompong, tšebeliso ea lik'habohaedreite li ntlafatsa le ho ntlafatsa mohopolo,
• ho na le ho otla ha pelo ka potlako, ebe - bohloko bo ka pelong,
• ho opeloa ke hlooho khafetsa ho hlaha 'me khatello ea mali e phahama,
• ho nyekeloa ke pelo, molomo o omileng le lenyora le eketsehileng le ka hlaha
• tšilo-hloko ea lieha ho theoha, ho qhala ho hlaha,
• matšoao a methapo ea methapo ea kutlo ea kemolo e ikemetseng - tachycardia, mofufutso o feteletseng, ts'ebelisano e mpe ea methapo le tse ling.

Ho boetse ho na le matšoao a kantle ho lefu lena. Ngaka e nang le boiphihlelo e ka fumana lefu la metabolic ho basali hanghang. Setšoantšo sa bakuli ba joalo se bontša letšoao le tloaelehileng ho bohle: botenya ka mofuta oa mpa. Sena se bolela hore mafura a bokellana haholo ka mpeng. Ho feta moo, eseng feela ka liseleng tse subcutaneous, empa le ho potoloha litho tsa ka hare, tse sitisang mosebetsi oa tsona ho feta. Ho lumeloa hore botenya ba mpa bo hlaha haeba boholo ba letheka la mosali bo feta lisentimitara tse 88.

Ntle le moo, o kanna oa bona matheba a khubelu molaleng le sefubeng se kaholimo. Ponahalo ea bona e amahanngoa le vasospasm ka khatello e eketsehileng kapa khatello ea maikutlo.

Liphephetso le litlamorao tsa metabolic syndrome

Ena ke lefu la kelello le sa foleng le tloaelo e matla ea tleleniki. Ntle le kalafo e nepahetseng, lefu la metabolic ho basali le baka litlamorao tse mpe. Khafetsa, ho sitisoa ha methapo ea mali ho baka infraction ea myocardial kapa stroke. Atherosclerosis, thrombophlebitis, kapa lefu la pelo le sa foleng le lona le ka hlaha.

Mme kalafo e sa lokang ea lefu la tsoekere la mofuta oa 2 e lebisa kholisong ea mofuta oa eona o itšetlehileng ka insulin. Keketseho e telele ea tsoekere ea mali ke sesosa sa ho foufala, ho tsofala pele ho nako, le ho se sebetse hantle ha lijana tse poteletseng. Gout kapa mafura a sebete le 'ona a ka ba teng. Hangata bakuli bana ba immunocompromised, kahoo hangata ba tšoaroa ke sefuba, bronchitis le pneumonia.

Haeba metabolic syndrome e hlaha ho basali ba lilemo tsa ho ba le bana, sena se ka baka ho hloka thari. Ka sebele, litlolo tlholehong ena ha li ame feela lik'habohaedreite le metabolism ea mafura. Litho tsohle le lisele tsohle lia utloa bohloko, ho senyeha ha li-hormone hangata ho bonoa. Li-ovary tsa polycystic, endometriosis, ho fokotsa ho tsamaisoa ha thobalano, ho hloka molao ho emeng ka nako ea menstrual.

Tsebiso ea lefu la metabolic

Ka tloaelo, bakuli ba nang le matšoao a joalo ba qala ba ea ho ngaka. Kamora ho hlahloba le ho bokella nalane ea bongaka, mokuli o fetisetsoa ho endocrinologist bakeng sa tlhatlhobo e eketsehileng le khetho ea mekhoa ea kalafo. Tlhahlobo ea mokuli eu lumella ho bona likarolo tsa bophelo le phepo e nepahetseng, boteng ba mafu a sa foleng. Ntle le moo, endocrinologist e etsa tlhahlobo ea kantle ea mokuli: e lekanya thekeng, e bala index ea boima ba 'mele. Empa eseng feela ka lipontšo tsena ke metabolic syndrome ho basali e ikemiselitseng. Ho tseba lefu la pathology hape ho na le liteko tsa laboratori. Hangata, liteko tsa mali le tsa moroto li etsoa bakeng sa sena. Ho ba teng ha metabolic syndrome ho bontšoa ke matšoao a joalo:

• triglycerides
• fokotsa khatello ea lipoprotein tse phahameng haholo,
• maemo a phahameng a cholesterol e mpe,
• glucose e se nang letho ea bonyane 5,5 mmol / l,
• insulin e ngata
• Limolek'hule tsa protheine le maemo a phahameng a uric acid a fumanoa moroto.

Ntle le moo, ho sebelisoa mekhoa e meng ea tlhahlobo. Liteko tsa mamello ea tsoekere, ho ithuta ho ruruha ha mali, tlhahlobo ea khatello ea mali ea letsatsi le letsatsi e ka etsoa.

Melao-motheo ea kalafo

Mokuli e mong le e mong o hloka mokhoa oa motho ka mong. Phekolo ea lefu la metabolic ho basali e fanoa ho latela lipalo tsa mali, tekanyo ea botena le boteng ba maloetse a kopaneng. Mesebetsi ea eona ea mantlha e lokela ho ba ho fokotsa boima ba 'mele, ho eketsa lisele tsa kutlo tsa insulin, ho etsa hore mekhahlelo ea metabolic le khatello ea mali, litekanyo tsa lihormone tse nepahetseng le ho ntlafatsa ts'ebetso ea tsamaiso ea pelo le methapo.

Hangata, ho sebelisoa mekhoa e latelang bakeng sa kalafo.

• Lijo tse khethehileng bakeng sa lefu la metabolic ho basali ke tsela e tlamang le e sebetsang haholo ea ho theola boima ba 'mele le ho etsa hore metabolism e se ke ea fetoloa.
• mokuli o boetse o eletsoa ho fetola mokhoa oa hae oa bophelo ka ho eketsa ho ikoetlisa,
• meriana e fapa-fapaneng e sebelisoa ho lokisa mathata a teng mesebetsing ea litho tsa ka hare,
• tšeetso ea kelello le ho boloka maikutlo a nepahetseng e bohlokoa haholo ho basali ba nang le ts'oaetso ea lefu lena.

Ho feta moo, mokuli a ka sebelisa mekhoa e meng. Ka thuso ea litlolo tsa setso tsa setso, metabolism e tloaelehile, boima ba 'mele boa fokotseha, phallo ea mali e ea ntlafatsoa. E ea sebetsa sanatorium ho phekola lefu la metabolic ho basali. Melao-motheo ea physiotherapy e sebelisitsoeng moo, e ntlafatsa methapo ea lik'habohaedreite le lipid metabolism, e khutsisa tsamaiso ea methapo, e nolofalletsa khatello ea mali. E sebetsang ka ho fetisisa bakeng sa merero ena ke balneotherapy, sesepa, tšelo ea metsi a nang le liminerale, electrotherapy.

Lithethefatsi bakeng sa kalafo ea metabolic syndrome

Phekolo ea lithethefatsi e fanoa ho latela botebo ba matšoao a lefu lena. Hangata, lithethefatsi li sebelisoa ho tloaela metabolism ea lipid le carbohydrate, ho eketsa kutloisiso ea lisele ho insulin, hammoho le khatello ea mali e tlase le ho ntlafatsa ts'ebetso ea pelo. Ka linako tse ling lithethefatsi li sebelisoa ho tloaela boemo ba mokokotlo oa hau. Meriana e khethoa ke ngaka ka bonngoe kamora tlhahlobo e felletseng.

• Bakeng sa kalafo ea mathata a metabolism ea lipid, ho fanoa ka litlhare tsa sehlopha sa statin le fibrate. E ka ba Rosuvastatin, Lovastatin, Fenofibrat.
• Ho ntlafatsa monko oa tsoekere ka lisele le ho matlafatsa kutloisiso ea bona ea insulin, ho hlokahala mekhoa e khethehileng le livithamini. Tsena ke "Metformin", "Glucophage", "Siofor", "Alpha Lipon" le ba bang.
• Haeba metabolic syndrome e hlaha ho basali ba menopausal, phekolo ea lihormone e sebelisoa. Tsena e ka ba lithethefatsi tse nang le estradiol le drospirenone.
• Li-inhibitors tsa ACE, li-blockers tsa calcium calcium kapa diuretics li sebelisoa ho khutlisa khatello ea mali le ho ntlafatsa ts'ebetso ea pelo. Lithethefatsi tse tloaelehileng ke Captopril, Felodipine, Bisoprolol, Losartan, Torasemide le tse ling.

Khafetsa, kalafo ea metabolic syndrome ho basali ba nang le lithethefatsi e reretsoe ho fokotsa boima ba 'mele. Maemong ana, ho sebelisoa mekhoa e thibelang takatso ea lijo le ho ntlafatsa boemo ba kelello ba mosali ha a hana lijo. Sena e kanna eaba, ka mohlala, sethethefatsi "Fluoxetine." Sehlopha se seng sa lithethefatsi tsa botenya se u lumella ho tlosa mafura kapele ka mala, u sa a lumelle hore a kenngoe maling. Hona ke Orlistat kapa Xenical. Ha ho ratehe hore metabolic syndrome e sebelise lithethefatsi tse tummeng tse khahlanong le botenya tse kang Prozac, Reduxin, Sibutramin, hammoho le lisebelisoa tsa phepo ea kajeno tsa lijo ntle le ho buisana le ngaka. Li ka baka litlamorao tse mpe.

Syndrome ea Metabolic

Bakeng sa ho theha mekhoa ea metabolic le ho eketsa kutloisiso ea lisele ho insulin, ho bohlokoa haholo ho eketsa ts'ebetso ea 'mele ea mokuli. Empa ha u bapala lipapali ho hlokahala hore u boloke melao e 'maloa, joale kalafo ea botenya e tla sebetsa:

• o hloka ho khetha mofuta oa papali e tla u thabisa, hobane o hloka ho ithabisa.
• Workouts e lokela ho ba letsatsi le letsatsi bonyane hora,
• Meroalo e hloka ho eketsoa butle butle, motho a ke ke a sebetsa ho feta,
• U ke ke oa sebetsana le khatello e phahameng ea mali, tlolo e tebileng ea pelo kapa liphio.

Ke thupelo efe e tla thusa batho ba nang le metabolic syndrome? Bakeng sa basali ba ka tlase ho lilemo tse 50, boikoetliso ba anaerobic le koetliso ea matla li loketse. Ena ke ho baleha, ho ikoetlisa ho simulators, squats, ho sesa ka lebelo le holimo, aerobics. Kamora lilemo tse 50, ho molemo ho etsa Nordic ho tsamaea, ho sesa, ho tants'a ka khutso, ho palama baesekele.

Phepo e nepahetseng ea metabolic syndrome

Ho fokotsa boima ba 'mele ke sepheo sa mantlha sa kalafo ea lefu lena. Empa molemong oa ho se lematse bophelo bo botle le ho feta, ho theola boima ba 'mele ho lokela ho etsahala butle. Ho lumeloa hore 'mele o lemoha, ntle le khatello ea maikutlo, tahlehelo ea khoeli le khoeli ea 3% ea boima ba pele. Sena ke hoo e ka bang li-kilos tse 2-4. Haeba u fokotsa boima ba 'mele kapele, mekhoa ea metabolic e tla theoha le ho feta. Ka hona, mosali o khothalletsoa ho ela hloko khetho ea lijo. Ho bohlokoa hore lijo li fuoe ka kotloloho ke ngaka. Tabeng ena, tekanyo ea botenya, ho ba teng ha mathata, lilemo tsa mokuli li tla nkoa.

Lijo tsa phepo ea metabolic ho basali li lokela ho ba tlase ho lik'habohaedreite le mafura. U hloka ho lahla confectionery, ho baka le ho baka, liswiti, nama e mafura le tlhapi, lijo tse ka makotikoting, raese, libanana, morara o omisitsoeng, mafura a hloekisitsoeng le lino tse tsoekere. Lijo li lokela ho ba le meroho e tala, litholoana tse sa jeoang, nama e mafura a fokolang, tlhapi le lihlahisoa tsa lebese, bohobe ba lijo-thollo tse felletseng, lijo-thollo tsa barele. Ntle le moo, o latela melao ena:

• o hloka ho ja ka likarolo tse nyane, empa eseng ho lumella likhefu tse kholo pakeng tsa lijo,
• Lijo tse phehiloeng hamolemo, tse phehiloeng kapa tse phehiloeng,
• Lijo tsohle li lokela ho hlafuna ka hloko,
• lijo li ka se hlatsuoe,
• o hloka ho fokotsa tšebeliso ea letsoai,
• ho khothalletsoa ho ngolisoa ka buka ea lijo.

Thibelo ea Metabolic Syndrome

Ho lumeloa hore basali ba bangata ba sejoale-joale ba khethetsoe lefu lena. Ka hona, o hloka ho tseba mokhoa oa ho itshwara e le ho thibela nts'etsopele ea metabolic syndrome:

• ja hantle, u se ke oa bolaoa ke tlala 'me u se ke ua latela lijo tse nang le khalori e tlase,
• tsamaea haholoanyane, etsa lipapali,
• kamehla etsa koetliso ea mmele le physiotherapy,
• Kamora lilemo tse 40, hlokomela boemo ba cholesterol le tsoekere maling,
• tlohela mekhoa e mebe le lijo tse potlakileng.

Hona joale Psychology ena e fumanoa ho motho e mong le e mong oa boraro. Ho bohlokoa haholo ho basali ba kaholimo ho lilemo tse 50 ho lekola boima ba bona, hobane metabolic syndrome e senya mosebetsi oa litho tsohle. Ka hona, ha matšoao a pele a pathology a hlaha, o hloka ho bona ngaka bakeng sa thuso. Ho feta moo, ha ho bohlokoa feela hore ho hlahlojoe le ho khetha lijo tse itseng, empa le tšehetso ea kelello.

Metabolic syndrome ho basali le banna - matšoao

Tloloko ea pele ea nts'etsopele ea metabolic syndrome ke boteng ba letheka la mosali le nang le bolelele ba li-cm tse fetang 80, mme monna o feta lisenthimithara tse 94. Haeba boholo bo ka holimo bo kopantsoe le keketseho ea khatello ea mali e phahameng ho feta 130/85 mm RT. la lilemo, ka tekanyo ea tsoekere e fetang 5.6 mmol / l, kapa keketseho ea cholesterol ea mali, boteng ba metabolic syndrome ha bo na lipelaelo.

Metabolic Syndrome - Lisosa

Lisosa tse ka sehloohong tsa metabolic syndrome:

1. liphetoho tse amanang le lilemo moqoqong oa li-hormone,
2. tšebeliso e ngata ea lijo tse se nang phepo,
3. ho hloka boikoetliso.

Sesosa se ka sehloohong sa lits'ebetso tsohle tsa metabolic syndrome ke INSULIN RESISTance, e leng boits'ireletso ba 'mele ho insulin.

Insulin e fana ka glucose ka seleng. Haeba sele e qala ho "bolaoa ke tlala" ka lebaka la ho haelloa ke tsoekere, joale boko bo amohela letšoao leo u hlokang ho le: 1) ja ntho e monate ka potlako (eketsa boemo ba tsoekere), 2) eketsa tlhahiso ea "insulin" e tla tsamaisa glucose ena ka seleng.

Tabeng ea metabolic syndrome, MECHANISM ea phepelo ea tsoekere seleng e RAHAKISITSOA, ke hore, ho na le phallo ea tsoekere maling maling ("tsoekere e phahameng"), mme glucose ena ha e kene seleng (mme motho o na le bofokoli le ho hloka matla).

Lebaka la "insulin" ee ke lefe? Taba ke hore ka hare ho sele ho na le batsamaisi ba laolang boemo ba glucose bo tlang. Haeba ho na le tsoekere e ngata ho feta kamoo e hlokahalang, sele e tla shoa. Ka hona, molemong oa hore sele e bule "heke" ea ho ts'oaroa ha tsoekere, lethathamo la liketsahalo tse amanang le li-MicroRNA li lokela ho qala ho hlaha kahare ho sele.

Sele e hloka li-nucleotide tse ngata tse tla haha ​​li-microRNA, tseo ka nako e 'ngoe li tla laola ts'ebetso ea tsoekere ea tsoekere. Empa ka lilemo, thepa ena ea moaho ka sebopeho sa li-nucleotide e ea fokola ebile e fokola.

Metabolic Syndrome - Phekolo

Pele ho tsohle, kalafo ea metabolic syndrome e lokela ho ikemisetsa ho rarolla bothata ba ho nona haholo. Hoa hlokahala ho eketsa ts'ebetso ea motor, ho fokotsa ho kenella ha caloric.

Ntlha ea bohlokoa haholo: ho bohlokoa ho eketsa livithamini le li-microelements tse hlokahalang bakeng sa 'mele lijong, haholo-holo tse thusang' mele ho aheng li-microRNA tse tla laola tsoekere ea tsoekere. 'Mele o hloka li-nucleotide.

Likhothaletso tsa rona tsa metabolic syndrome

Ho tlatsa khaello ea li-nucleotide 'meleng, o ka sebelisa litokisetso tsa Dienai. Hoo e batlang e le litokisetso tsohle tsa mola oa Dienai ke mohloli oa li-nucleotide.

Haeba ho ka ba joalo lefu la metabolic ho basali, ka nako eo o ka khothaletsa lithethefatsi tse kang Panmelan, Dienai.

Ho lefu la metabolic ho banna Tarkus e khothalletsoa. Tarkus ke sethethefatsi se thusang 'mele oa monna ho boloka lihormone, ho boloka maemo a testosterone (hormone ea banna e ka sehloohong). Ho fokotseha ha litekanyetso tsa testosterone ho tsamaisana le ho fokotseha ha mesifa le mesifa, ho eketseha ha mesifa ea adipose, osteoporosis, le ho fokotseha ha molumo oa letlalo le botenya (letlalo le sa tsitsang). Khabareng, keketseho ea boima ba 'mele ka lebaka la lithane tsa adipose e lebisa ho fokotseheng ho eketsehileng ha testosterone. Ho na le "potoloho e mpe" ha mafura a mangata mmeleng ka nako e fetohang a ka fetola monna sebopuoa sa bong bo pakeng. Taba ke hore 'meleng oa monna, ho ekelletsa ho androgens le testosterone, palo e nyane ea lihomone tsa basali e lula e hlahisoa,' me ho basali - lihormone tsa banna. Haeba boima ba monna bo phahame ka 30% ho feta bo tloaelehileng, sistimi ea endocrine e emisa tlhahiso ea testosterone mme e eketsa tlhahiso ea estrogen le progesterone. Tlas'a tšusumetso ea bona, motho e motona o nka sebopeho se matla. Tarkus ea rona ea lithethefatsi e thusa 'mele oa monna ho hlahisa testosterone ea eona, ka tsela eo e thusa ho hlola boemo bona.

Nka thusa neng

Liwebosaete tsa video

1) "metabolic syndrome ke eng le ho e tseba ka nako"

2) "Khalemelo ea motsoako oa metabolic le lithethefatsi tsa Dienai"

Litlamorao tsa metabolic syndrome

Ka sehloohong mathata a metabolic syndrome ke:

• mofuta oa lefu la tsoekere
• pelo, sejana sa mali, le mafu a boko
• ho se sebetse hantle hantle ha renal

Lintho tsa mantlha tsa metabolic syndrome ke ho hanyetsa insulin le hyperglycemia. Haeba likarolo tsena tse peli li sebetsa ka nako e telele 'meleng, haholo-holo ho metabolism ea lik'habohaedreite, o na le monyetla o motle oa ho tobana le lefu la tsoekere le tletse.

Lefu la tsoekere le lona le ka lebisa ho bofofu, mathata a ho potoloha, mathata tsamaisong ea methapo ea kutlo, ho se sebetse hantle ha masapo le lefu la pelo.

Ho hanyetsa insulin ho etsa qeto ea nts'etsopele ea dyslipidemia (eketseha cholesterol ea LDL e amanang le ho fokotseha ha HDL), e tlatsetsang kholisong ea atherosulinosis: cholesterol e ngata maling e kenyelitsoe marong a methapo ea mali, e le hore lumen ea lijana e senyehe le ho feta ebe, qetellong, ea koaloa.

Ha sena se etsahala, ho hlaha ischemia, e ka bang ho otla ha pelo haeba e ama methapo ea methapo ea kutlo, kapa stroke haeba methapo ea kelello e amehile. K'holeseterole e ngata e kenella ka har'a sebete 'me e lula moo, e leng ho bakang mafura a sebete.

Batho ba bang ba nang le lefu la metabolic ba na le keketseho ea mahloriso a plasma uric acidho ka lebisang ho gout.

Ho ne ho boetse ho na le kamano pakeng tsa metabolic syndrome le psoriasis le lipakeng tsa metabolic syndrome le mefuta e fapaneng ea lihlahala.

Thibelo ke mokhoa oa mantlha oa kalafo

Bohlokoa Lijo tse tlase tsa khalori, e thusang ho theola boima ba 'mele, hammoho le ho fokotsa tsoekere ea mali, cholesterol le triglycerides.

Mofuta ono oa lijo takatso ea letsatsi le letsatsi ea 1200-1600 kcal, ho ipapisitse le litšobotsi tsa motho le ho leka-lekana kamanong ea melao-motheo e meng ea phepo.

Ho Lijo li lokela ho fokotsoa ka letsoaiho kokobetsa khatello.

Bohlokoa haholo ho ikoetlisa, kaha e re thusa ho potlakisa ts'ebetso ea ho theola boima ba 'mele le ho fokotsa khatello ea insulin ea lisele tsa mesifa, hobane lisele tsa mesifa li khona ho monya tsoekere ntle le ho nka karolo ha insulin feela nakong ea boikoetliso.

Hoa hlokahala ho hana ho tsuba koae le ho se noe joala, ho fokotsa khatello ea kelello bophelong ba letsatsi le letsatsi.

Tlhaloso ea lefu lena. Lisosa tsa lefu lena

Metabolic syndrome (Reaven syndrome) ke letšoao le kopanyang botenya, ho hanyetsa insulin, hyperglycemia (tsoekere e phahameng ea mali), dyslipidemia le lefu la methapo ea kutlo. Ts'oaetso tsena kaofela li hokahane ka ketane e le 'ngoe ea pathogenetic. Ntle le moo, lefu la mofuta ona le kopantsoe le hyperuricemia (acid e eketsehileng maling), lefu la ho senyeha (ho hlohlona ha mali), ho ruruha ho sa feleng, ho koaleha ka nakoana boroko ba apnea-hypopnea (ho ts'oaroa ha boroko boroko).

Metabolic syndrome ke lefu le sa foleng, le atileng (ho fihla ho 35% ho baahi ba Russia), lefu la polyetiological (le hlahang ka mabaka a mangata), moo mabaka a boits'oaro (hypodynamia, khaello ea phepo e nepahetseng, khatello ea maikutlo) a bapala karolo e kholo. Taba ea lefutso e tlang pele ho lefu la khatello ea mali, maloetse a itšetlehileng ka lefu la atherosclerosis le lefu la tsoekere la 2 le eona e bohlokoa.

Ho bohlokoa ho litsebi hore li khetholle sehlopha sa kotsi bakeng sa metabolic syndrome. Sehlopha sena se kenyelletsa bakuli ba nang le matšoao a lefu lena le mathata a lona: khatello ea methapo ea methapo, phetoho ea lik'habohaedreite, botenya le ho eketseha ha phepo e nepahetseng, lefu la pelo, mafu a atherosulinotic a methapo ea methapo ea pelo le mokokotlo, lefu la metabolite le senyehileng, mafura a sebete, lefu la polycystic ovary, nako ea postmenoparance. basali le ho se sebetse hantle ha erectile ho banna, ho ikoetlisa 'meleng, tšebeliso e mpe ea joala, ho tsuba, mojaro oa lefa la pelo le metabolism Ho kula.

Matšoao a metabolic syndrome

Pontšo ea kliniki ea metabolic syndrome e tsamaisana le matšoao a likarolo tsa eona:

• botenya ka mpeng,
• khatello ea kelello ea methapo
• liphetoho phetohong ea carbohydrate, lipid le purine metabolism.

Haeba liphetoho tse teng likarolong tsa Reaven syndrome li fokola ka tlhaho (e leng ntho e atileng), joale lefu lena le asymptomatic.

Pathogenesis ea metabolic syndrome

Ho hanyetsa insulin ke sesosa sa kholo ea kholo ea metabolic. Ke tlhekefetso ea ts'ebeliso ea tsoekere ho litho tsa 'mele (sepheo sa mesifa e thothomelitsoeng, lipocytes le sebete) tse amanang le ho se sebetse hantle ha insulin. Ho hanyetsa insulin ho fokotsa ho monya le ho kenella ha glucose liseleng tsa mesifa ea masapo, ho matlafatsa lipolysis le glycogenolysis, e lebisang phetohong ea lipid le carbohydrate. Ntle le moo, ho hanyetsa insulin ho ntlafatsa secretion ea insulin, ho etsa hore hyperinsulinemia e sebetsanang le ts'ebetso ea methapo ea endocrine (kutloelo-bohloko, renin-angiotensin-aldosterone) ka ts'ebetso ea methapo ea methapo ea kutlo, tlolo ea molao ea ts'ebetso ea metabolic, hypercoagulation, subclinical le dysfunction. Liphetoho tsena, li thusa ho hanyetsa insulin haholo, e leng ho tsosetsang "mokokotlo o mpe" oa pathogenetic.

Classified le mekhahlelo ea nts'etsopele ea metabolic syndrome

Ha ho na khethollo e hlakileng le ho hlaka ea metabolic syndrome. Ho arohana ha eona ke bangoli ba bang ka botlalo, ho kenyelletsa likarolo tsohle tsa lefu lena, 'me ho sa fella ho bonahala ho sa utloahale. Leha ho le joalo, ho teba ha matšoao, palo ea likarolo tsa Reaven syndrome le ho ba teng ha mathata li ama khahlano le kotsi le khetho ea maano a kalafo ho mokuli ea itseng. Ho etsa sena, nahana ka:

• tekanyo ea botenya le khatello e phahameng ea mali,
• botebo ba liphetoho tsa metabolic,
• ho ba teng kapa ho se be teng ha lefu la tsoekere le mafu a amanang le atherosulinosis.

Ho latela index ea boima ba 'mele (BMI), e baloang ka ho arola boima (kg) ka bolelele (m 2), mefuta e latelang ea boima ba' mele (MT) e thathamisitsoe:

tloaelehileng MT - BMI ≥18.5 80 cm ho basali le 94 cm ho banna, mme ka RT> 88 cm le 102 cm, ka ho latellana, kotsi e eketseha haholo.

Khokahano ea mantlha ea methapo ea methapo ho metabolic syndrome ke phetoho ea metabolism ea carbohydrate. Ho kenella ka glucose ho hlahlojoa maling a capillary (tloaelehileng 1
basali > 1.2monna > 1
basali > 1.2monna > 1
basali > 1.2monna > 1
basali > 1.2 Khaled≤1,7≤1,7≤1,7≤1,7 XC
e seng HDL≤4,3≤3,8≤3,3≤2,6 Tlhokomeliso:
OH - k'holeseterole e felletseng,
LDL-C - cholesterol e tlase haholo.
HDL-C - cholesterol e ngata e phahameng haholo.
K'holeseterole eo e seng HDL - k'holeseterole eo eseng ea lipoprotein
letsoalo le phahameng.

Liphetoho tsa metabolic syndrome

Kaha metabolic syndrome ke motsoako oa lintho tse ka bakang mafu a pelo le methapo, ke tsona lintho tse tsamaisang mathata ana. Ha re bua haholo ka lefu la tsoekere, lefu la pelo le mathata a lona: lefu la tsoekere, "neuro-" le nephropathy, ho hloleha ha pelo, ho nyekeloa ke pelo, lefu la pelo le ts'ebetso, lefu la pelo le tšohanyetso, mafu a amanang le lefu la pelo le mafu a methapo ea methapo. . Tsoelo-pele ea khatello ea mali e boetse e baka tšenyo ea litho tsa hau tse boletsoeng le maemo a amanang le kliniki.

Phekolo ea Metabolic Syndrome

Phekolo ea metabolic syndrome e lokela ho aroloa hore e se lithethefatsi le lithethefatsi.

Phekolo eo eseng ea lithethefatsi Reaven syndrome e bolela ho boloka bophelo bo phetseng hantle, ho khaotsa ho tsuba le tšebeliso e mpe ea joala, ho ikoetlisa ka tsela e nepahetseng, phepo e nepahetseng, hammoho le tšebeliso ea mabaka a tlhaho le a ntlafalitsoeng a pheko (ho silila, ho hlapa ka metsi ka tlasa metsi, kalafo ea hypoxic le hypercapnia, hydrotherapy, thalassotherapy, balneotherapy - le thermotherapy, phallo ea kahare ea metsi a liminerale, litlamorao tse akaretsang tsa methapo ea kutlo), mekhoa ea kelello le mananeo a koetliso.

Phekolo ea lithethefatsi metabolic syndrome, ho latela ho ba teng ha e 'ngoe ea tsona kapa tse ling tsa likarolo tsa eona, e ka kenyelletsa ho fokotsa lipid, lithethefatsi tse thibelang antihypertgency, meriana ea ho fokotsa ho hanyetsa insulin, hyperglycemia ea postprandial le boima.

Lithethefatsi tse ka sehloohong tse sebelisoang ho phekola khatello ea mali ea methapo ho bakuli ba nang le lefu la tsoekere le lefu la tsoekere ke angiotensin-converting enzyme inhibitors, sartans le imidazoline receptor agonists. Leha ho le joalo, ho fihlela boemo ba sepheo sa khatello ea mali, ho kopana ha mefuta e fapaneng ea meriana, joalo ka li-blockchain tse liehang ho feta tsa calcium, ba khethang beta-blockers haholo le di-thiazide-like diuretics (indapamide) hammoho le meriana ea mola oa pele.

Ho lokisa likotsi tsa metabolism ea lipid ka har'a metabolic syndrome, li-statin li sebelisoa qalong, mohlomong motsoako oa tsona le ezetrol le fibrate. Mochine o ka sehloohong oa ts'ebetso ea li-statins ke ho fokotseha ha methapo e rarahaneng ea OX ka lebaka la ho khutla ha thibelo ea enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase. E lebisa keketseho ea palo ea li-receptor tsa LDL-C holim'a hepatocyte le ho fokotseha hoa khatello ea LDL-C maling. Ntle le moo, li-statins li na le litlamorao tse khahlisang, joalo ka antithrombogenic, anti-inflammatory, le ntlafatso ea ts'ebetso ea endothelial, e lebisang ho tsitsitseng ea atherosranceotic plaque. Lipalo-palo tsa sejoale-joale li khona, hammoho le ho fokotseha ha LDL-C ho isa ho 55%, ho fokotsa li-triglycerides ho 30% le ho eketsa HDL-C ho 12%. Ka nako e ts'oanang, monyetla o ka sehloohong oa kalafo ea "statin" ke ho fokotsa mathata a pelo le lefu ka kakaretso. E sebetsa hantle haholo ho sebelisa atorvastatin (10-80 mg / letsatsi) kapa rosuvastatin (5-40 mg / letsatsi).

Ka ho se sebetse hantle ha statin monotherapy, ho bohlokoa ho eketsa ezetrol ka tekanyetso ea 10 mg / ka letsatsi, e thibelang ho kenngoa ha OH ka mpeng mme e ka eketsa ho fokotseha ha LDL-C ka 15-20%.

Fibrate ke sehlopha se seng sa lithethefatsi tse fokotsang lipid. Li senya likaroloana tsa mafura tse nang le li-triglycerides, li fokotsa ho kopana ha mafura acid le ho eketsa HDL-C ka ho phahamisa ho phatloha ha LDL. Sena se lebisa ho fokotseha ho hoholo ha triglycerides (ho fihla ho 50%), LDL-C (ho fihla ho 20%) le keketseho ea HDL-C (ho fihla ho 30%). Li-Fibrate li boetse li na le litlamorao tsa ho khahlisa: ho fokotsa ho kenella ha uric acid, fibrinogen le ho ntlafatsa kutloisiso ea insulin, empa phello ea bona e ntle ho nts'etsopele ea bakuli ha e so bonoe. Sesebelisoa se sebetsang le se sireletsehileng ka ho fetisisa sehlopheng sena ke fenofibrate 145 mg / ka letsatsi.

Ho fokotsa ho hanyetsa insulin, sethethefatsi sa khetho ke metformin, e nang le phello e ntle ho hanyetsanang le insulin ka ho eketseha ha tsoekere ea glucose ka lisele tsa sepheo. Metformin e fokotsa sekhahla sa ho kenngoa ha lik'habohaedreite ka mpeng e nyane, e na le phello ea anorexigenic, e fokotsa tlhahiso ea tsoekere ke sebete, hape e ntlafatsa sephethephethe sa glucose ka har'a lisele. Litlamorao tse ntle tsa metformin (1500-3000 mg / letsatsi) lipheletsong li bakoa ke ho fokotseha ha insulin, litla-morao tsa metabolic (boima ba 'mele, ho ferekana ha lipid, mabaka a ho fetoha, joalo-joalo).

Ho fokotsa hyperglycemia ea postprandial, ho sebelisoa acarbose, e thibelang li-glucoamylase, sucrose le maltase kahara mala a manyane a holimo. Ka lebaka leo, lik'habohaedreite tse sa koaeloang li fihla ka mpeng, 'me monko oa lik'habohaedreite o lieha ho feta. Leha ho le joalo, acarbose e senotse litlamorao tse ling. Phuputso ea STOP-NIDDM (2002) ho bakuli ba nang le metabolic syndrome ba nkang acarbose ka tekanyetso ea 300 mg / ka letsatsi e bontšitse ho fokotseha ha nts'etsopele ea lefu la tsoekere ka 36%, linyeoe tse ncha tsa khatello ea methapo ka 34%, le kakaretso ea liketsahalo tsa pelo ka 46%.

Haeba mokuli ea nang le lefu la tsoekere la Reaven a na le lefu la tsoekere la mofuta oa 2, ho ka sebelisoa lihlopha tsa sejoale-joale tsa lithethefatsi tsa hypoglycemic, tse kang glucagon-like peptide-1 analogue, dipeptidyl peptidase-4 inhibitor, le mofuta oa 2 glucose transporter inhibitor. Moemeli oa sehlopha sa ho qetela sa empagliflozin (Jardins) thutong ea EMPA-REG OUTCOME (2016) o fokolitse lefu la pelo ho bakuli ba nang le lefu la 2 lefu la tsoekere ka 36%.

Khalemelo ea lithethefatsi ea botenya bo feteletseng e bonts'oa ha kalafo e seng ea lithethefatsi e sa lebise ho fokotseha ha boima ba 'mele ka ho feta 5% ho tloha ho qalong. Lithethefatsi tsa ho phekola botenya li arotsoe ho li-anoretics tse ka hare-hare (sibutramine), le lithethefatsi tse amang tšitiso ea mpa, joalo ka orlistat (Xenical).

Setlhare sa ho fokotsa takatso ea lijo, sibutramine, ho isa tekanyong e nyane se ama dopamine le ts'ebetso ea cholinergic, empa se fokotsa tšebeliso ea mafura le lik'habohaedreite, tse lebisang ho fokotsa boima ba 'mele hape li ntlafatsa metabolism ea mafura le carbohydrate. Khatello ea mali le lebelo la pelo ka nako e ts'oanang le eketseha ka 5% feela.

Orlistat ke inhibitor ea li-gastric le pancreatic lipases, ka lebaka leo karolo ea boraro ea li-triglycerides tsa lijo e sa kenngoeng mme khatello ea bona maling e fokotseha, e lebisang ho fokotseha ha khalori ea lijo le boima. Ho feta moo, khatello ea mali, glucose le ho hanyetsa insulin lia fokotseha.

Ts'ebetsong ea bongaka, kalafo ea metabolic syndrome e itšetlehile ka ho ba teng le ho teba ha likarolo tsa eona. Tafole e ka tlase e bonts'a maano a ho khetha kalafo bakeng sa likhetho tsa Reaven syndrome tse atileng haholo.

Lisosa tsa Metabolic Syndrome

Lisosa tse ka sehloohong tsa metabolic syndrome li nkoa e le tsona tlholeho ea mokuli ho hanyetsanang le insulin, tšebeliso ea tsona e feteletseng ea mafura, hammoho le ho hloka mesebetsi ea makoloi.

Karolo e ka sehloohong ho nts'etsopele ea lefu lena ke ho hanyetsa insulin. Hormone ena 'meleng oa motho e ikarabella bakeng sa mesebetsi e mengata ea bohlokoa, empa sepheo sa eona sa mantlha ke ho tlama li-receptor tse e mamelang, tse fumanoang kahare ea sele ka' ngoe. Kamora puisano e lekaneng, ts'ebetso ea ho tsamaisa glucose ka seleng e qala ho sebetsa. Insulin ea hlokahala e le hore ho buloe "liheke tsena tsa ho kena" bakeng sa tsoekere. Leha ho le joalo, ha li-receptor li lula li se na insulin, tsoekere e ke ke ea kena seleng 'me ea bokellana maling. Ho eketseha ha insulin maling le hona hoa etsahala.

Kahoo, lisosa tsa nts'etsopele ea metabolic syndrome ke:

Phello ea lefutso ea ho hanyetsa insulin

Batho ba bang ba na le tšekamelo ena esale pele.

Liphetoho tse hlahisoang ke 'mele oa "chromosome" ea 19 li lebisa mathateng a latelang:

Lisele li ke ke tsa ba le li-receptor tse lekaneng tse amehang ka insulin,

Ho ka ba le li-receptor tse lekaneng, empa ha li na kutloelo-bohloko bakeng sa insulin, ka lebaka leo tsoekere le lijo li kentsoeng lithong tsa adipose,

Ho se sireletsehe ha motho ho ka hlahisa li-antibodies tse thibelang li-cell receptors tse nang le insulin,

Insulin e sa sebetseng e tla hlahisoa ke makhopho a pancreas nakong eo thepa ea 'mele e ikarabellang tlhahisong ea protheine ea beta.

Ho na le liphetoho tse ka bang 50 liphatseng tsa lefutso tse ka lebisang ho hanyetsanang le insulin. Bo-rasaense ba na le maikutlo a hore kutloisiso ea insulin ho batho e theohile haholo ka lebaka la thuto ea ho iphetola ha lintho, e entseng hore mmele oa hae o mamelle ka katleho tlala ea nakoana. Hoa tsebahala hore hangata batho ba mehleng ea khale ba ne ba e-ba le khaello ea lijo. Lefatšeng la kajeno, tsohle li fetohile haholo. Ka lebaka la ho ja haholo lijo tse nang le mafura le lik'hilojule tse ngata, ho bokellloa mafura a visceral ebe ho hlaha mofets'e oa metabolic. Ntle le moo, motho oa sejoale-joale, ha a busa, ha a na lijo, 'me o ja lijo tse mafura haholo.

Phekolo ea lithethefatsi ea metabolic syndrome

Haeba ngaka e lumela hore u lokela ho sebelisa thuso ea lithethefatsi, u se ke ua hana ho fetola mokhoa oa bophelo, o tla potlakisa ho hlaphoheloa le ho fokotsa litekanyetso tsa lithethefatsi.

Meriana e boletsoeng ke ngaka e itšetlehile ka nyeoe e ikhethileng: insulin kapa lithethefatsi tsa hypoglycemic ho ntlafatsa tsoekere ea mali, li-statins ho theola cholesterol, diuretics kapa beta blockers ho theola khatello ea mali..

Tlatsetso le omega 3, e ntlafatsang cholesterolemia le ho fokotsa ho ruruha ha mali, ka tsela eo e fokotsa kotsi ea ho tšoaroa ke pelo le stroke.

Bokapele ba lijo tse nang le mafura a mangata

Ha boima ba mafura a mangata a nooang a feta matla a mmele ho a hlophisa le ho a tsoala, joale botenya bo qala ho hola le ho tsoela pele. (bala hape: Botenya - tekanyo ea botenya le lisosa tsa eona)

Li-acid tse nang le mafura li ama hampe phospholipids e fumanehang kahara lisele tsa 'mele, li baka liphetoho sebopeng sa tsona. Ka lebaka leo, tsoekere ha e khone ho kena ka seleng ka tsela e tloaelehileng. Hape, u se ke oa lebala nako eo ka eona mafura a nang le khalori e phahameng e bapisoang le lik'habohaedreite le liprotheine. Bohlokoa bona bo fapana ho feta makhetlo a 2. Kahoo, haeba 1 g ea mafura e na le 9 kcal, joale liprotheine le lik'habohaedreite ke 4 kcal feela. Hoa utloahala hore 'mele oa motho o chechisetsa lik'hilojule tse eketsehileng tse tsoang lijong mabenkeleng a mafura.

Hypodynamia

Ho ikoetlisa ka mokhoa o fokolang ke lebaka le leng hape la nts'etsopele ea metabolic syndrome. Haeba motho a sa sisinyehe haholo, joale o fokotsa ts'ebetso ea ho petsoha mafura ho lipases, ho feta moo, palo e kholo ea li-triglycerides e bolokiloe ho adipose le tiske ea mesifa, mme glucose e kena mesifa ka molumo o fokolang. Ka lebaka leo, metabolic syndrome ea hlaha.

Bongaka

Lithethefatsi tse ling li kenya letsoho ha motho a e-na le keketseho ea boima ba 'mele.

Har'a litlhare tsena:

Li-antipsychotic (clozapine, olanzapine, risperidone),

Lithethefatsi tse theolelang tsoekere e maling (sulfonylureas, glitazones),

Li-anticonvulsants (carbamazepine, valproic acid),

Bareki ba Adrenergic (Beta le Alfa),

Lithibela-pelehi tsa Hormonal (gestagens).

Ke mabaka ana a mane (tlhahlobo ea tlhaho ea lefutso, khaello ea phepo e nepahetseng, ho se sebetse hantle ha 'mele, le meriana) tse lebisang ho thehoeng ha metabolic syndrome.

Leha ho le joalo, ho ka etsahala ho khetholla mabaka a kotsi a susumetsang kholo ea ona:

Male

Ts'ebeliso e mpe ea litloaelo tse mpe,

Khatello ea kelello ea nako e telele 'meleng,

Malwetse a mang (Werner syndrome, syndrome ea malapa a ho hanyetsa insulin, Rabson-Mendenhall syndrome).