Thiogamma analogues
Thiogamma ke sethethefatsi sa antioxidant le metabolic se laolang metabolism ea carbohydrate le lipid.
Ntho e sebetsang ea lithethefatsi ke thioctic (alpha-lipoic) acid. Ke antioxidant ea endo native e tlamang li-radicals tsa mahala. Thioctic acid e thehoa 'meleng ka nako ea oxidative decarboxylation ea alpha-keto acid.
Thioctic acid e laola metabolism ea carbohydrate le lipid, e ntlafatsa ts'ebetso ea sebete mme e matlafatsa metabolism ea cholesterol. E na le hypolipidemic, hypoglycemic, hepatoprotective le hypocholesterolemic effect. E khothaletsa phepo e ntlafalitsoeng ea li-neuron.
Alfa-lipoic acid e thusa ho fokotsa tsoekere ea mali, e eketsa bongata ba glycogen sebete le ho hlola insulin. Ka mochine oa ts'ebetso, e haufi le livithamini tsa sehlopha sa B.
Boithuto mabapi le likhoto tse nang le lefu la tsoekere la streptozotocin le bonts'itseng li bonts'itse hore thioctic acid e fokotsa sebopeho sa lihlahisoa tsa glycation, e ntlafatsa phallo ea mali a endoneural, mme e eketsa boemo ba antioxidants ea 'mele joalo ka glutathione. Bopaki ba boithuto bo fana ka maikutlo a hore thioctic acid e ntlafatsa ts'ebetso ea "peripheral neuron".
Sena se sebetsa le lits'oants'o tsa maikutlo ho lefu la tsoekere la polyneuropathy, joalo ka dysesthesia, paresthesia (ho chesa, ho utloa bohloko, ho akheha, ho fokotseha ha kutloisiso). Litlamorao li netefalitsoe ke liteko tsa tleliniki ea multicenter tse entsoeng ka 1995.
Mefuta ea tokollo ea lithethefatsi:
- Matlapa - 600 mg ea ntho e sebetsang ho e 'ngoe le e' ngoe.
- Tharollo ea tsamaiso ea botsoali ea 3%, li-ampoule tsa 20 ml (ka ampoule 600 mg ea ntho e sebetsang),
- Thiogamm-turbo - tharollo bakeng sa infusion ea botsoali 1.2%, li-vials tse 50 ml (ka botlolong e le 'ngoe ea 600 mg ea ntho e sebetsang).
Matšoao a ho sebelisoa
Ke eng e thusang Tiogamma? Fana ka moriana maemong a latelang:
- Lefu la sebete sa mafura (lefu la mafura a sebete),
- Hyperlipidemia ea tlhaho e sa tsejoeng (mafura a phahameng a mali)
- Chefo ea limela tse putsoa (tšenyo e nang le chefo ea sebete),
- Ho hloleha ha sebete
- Lefu la sebete la joala le litlamorao tsa lona,
- Hepatitis ea tšimoloho efe kapa efe,
- Hepatic encephalopathy,
- Cirrhosis ea sebete.
Litaelo tsa ho sebelisa Thiogamma, litekanyetso
Matlapa a nooa ka molomo, ka mpeng e se nang letho, a hlatsuoa ka metsi a manyane.
Motsoako o khothalelitsoeng ke Letlapa le le leng la Tiogamm 600 mg 1 nako ka letsatsi. Nako ea kalafo e itšetlehile ka ho teba ha lefu lena le ho tloha matsatsing a 30 ho isa ho a 60.
Kamora selemo, tsela ea kalafo e ka phetoa makhetlo a 2-3.
Liente
Litlhare li fanoa ka iv ka tekanyo ea 600 mg / ka letsatsi (1 amp. Tsepamisa maikutlo bakeng sa ho hlophisoa ha tharollo ea infusion ea 30 mg / ml kapa botlolo e le 'ngoe ea tharollo ea infusion ea 12 mg / ml).
Qalong ea thupelo, ho khothalletsoa ho tsamaisoa iv bakeng sa libeke tse 2 ho isa ho tse peli. Ebe o ka tsoela pele ho sebelisa moriana o kahare ka tekanyetso ea 300-600 mg / ka letsatsi.
Ha o etsa infusion ea methapo, lithethefatsi li lokela ho tsamaisoa butle, ka tekanyo e sa feteng 50 mg / min (e lekanang le 1,7 ml ea ho tsepamisa mohopolo bakeng sa ho hlophisoa ha tharollo ea infusion ea 30 mg / ml).
Lokisetsa tharollo ea infusion - litaba tsa ampoule e le 'ngoe ea mohopolo li lokela ho kopanngoa le 50-250 ml ea tharollo ea chloride ea 0,9%. Botoro e nang le tharollo e entsoeng hantle e koahetsoe ka sekoaelo se sirelelitseng bobebe, se tlisoang ke moriana ka botlalo. Tharollo e lokiselitsoeng e ka bolokoa ha ho feta lihora tse 6.
Haeba ho sebelisoa sesebelisoa sa infusion se itokiselitseng, botlolo ea moriana e ntšoa ka lebokoseng ebe hang-hang e koaheloa ka lebokose le sireletsang. Selelekela se etsoa ka kotloloho ho tsoa botlolong, butle - ka lebelo la 1,7 ml / motsotso.
Litlamorao
Thiogamma e kanna ea amahanngoa le litlamorao tse latelang:
Ho tsoa ho ts'ilo ea lijo: ha u sebelisa moriana kahare - dyspepsia (ho kenyelletsa ho nyekeloa pelo, ho hlatsa, ho opeloa ke pelo).
- Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: ka seoelo (kamora taolo ea iv) - lits'oants'o, diplopia, ka tsamaiso e potlakileng - khatello e eketsehileng ea intracranial (ponahalo ea maikutlo a boima hloohong).
- Ho tsoa tsamaisong ea mali ea mali: ka seoelo (kamora ho tsamaisoa ha iv) - bua ka hemorrhages ka mucous membrane, letlalo, thrombocytopenia, hemorrhagic rash (purpura), thrombophlebitis.
- Ho tsoa ts'ebetsong ea ho hema: ka ho potlakela ho kenella / kenyelletsong, ho hema ka thata hoa khoneha.
- Litlamorao: urticaria, systemic reaction (ho fihlela nts'etsopele ea anaphylactic shock).
- Tse ling: hypoglycemia e ka hlaha (ka lebaka la ho ntlafatsoa ha tsoekere).
Contraindication
Thiogammia o kopantsoe le linyeoe tse latelang:
- bana le bacha ba ka tlase ho lilemo tse 18,
- nako ea kemaro
- nako ea kemolo
- glucose-galactose malabsorption, khaello ea lactase, ho hloka mamello ea lefa la galactose (bakeng sa matlapa),
- hypersensitivity ho metsoako ea mantlha kapa e thusang ea lithethefatsi.
Khahlano le semelo sa tšebeliso ea lithethefatsi, joala bo ke ke ba nkuoa, hobane tlasa ts'usumetso ea ethanol, monyetla oa ho ba le mathata a maholo ho tsoa ts'ebetsong ea methapo le tšilo ea lijo li eketseha.
Li-analog tsa Thiogma, theko ea meriana
Haeba ho hlokahala, o ka nkela Thiogamma sebakeng sa analogue ea ntho e sebetsang - tsena ke lithethefatsi:
Ha u khetha li-analogues, ho bohlokoa ho utloisisa hore litaelo tsa tšebeliso ea Tiogamma, theko le litekolo tsa lithethefatsi tse nang le litlamorao tse tšoanang ha li sebetse. Ho bohlokoa ho fumana tlhahlobo ea ngaka le ho se etse phetoho e ikemetseng ea lithethefatsi.
Litheko makaleng a litlhare a Moscow: Tharollo ea Thiogamma 12 mg / ml 50 ml - ho tloha 197 ho isa ho li-ruble tse 209. Matlapa a 600 mg 30 likhomphutha. - ho tloha ho li-ruble tse 793 ho isa ho tse 863.
Tsoela hole le bana, u sirelelitsoe ke khanya, ka mocheso o fihlang ho 25 ° C. Bophelo ba Shelf ke lilemo tse 5. Ka litlama tsa meriana, lengolo la ngaka lea fumaneha.
Maikutlo a 3 bakeng sa "Tiogamma"
E thusa haholo. 'Mele o liela moriana ona makhetlo a 2 ka selemo. Kamora ho e sebelisa, o ikutloa a le betere haholo!
Ke ile ka fuoa lerotholi la tahi le thiagia ka 14.00 thapama, 'me ka 24.00 bosiu khatello ea nyoloha ho 177 ka 120. Hlooho ea ka e ne e utloile bohloko haholo, ke nahana hore e tla phatloha. Ka tsela e itseng o ile a theola khatello ea Correfar le Kapoten. Ke hlokometse hore karabelo e joalo ho tiagammu 🙁
Setsebi sa Cardiologist se file mora oa hae polelo e itseng, empa eseng sethethefatsi sena.
Li-analog mabapi le sebopeho le pontšo ea ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Alpha lipon alpha lipoic acid | -- | 51 UAH |
| Berlition 300 Oral | -- | 272 UAH |
| Berlition 300 thioctic acid | 260 rub | 66 UAH |
| Dialipon thioctic acid | -- | 26 UAH |
| Espa lipon thioctic acid | 27 rub | 29 UAH |
| Espa lipon 600 thioctic acid | -- | 255 UAH |
| Alpha Lipoic Acid Alpha Lipoic Acid | 165 rub | 235 UAH |
| Oktolipen | 285 rub | 360 UAH |
| Berlition 600 thioctic acid | 755 rub | 14 UAH |
| Dialipon Turbo thioctic acid | -- | 45 UAH |
| Tio-Lipon - Nocopharm thioctic acid | -- | -- |
| Thiogamm Turbo thioctic asiti | -- | 103 UAH |
| Tioctacid thioctic acid | 37 rub | 119 UAH |
| Thiolept thioctic acid | 7 rub | 700 UAH |
| Tioctacid BV thioctic acid | 113 rub | -- |
| Thiolipone thioctic acid | 306 rub | 246 UAH |
| Altiox thioctic asiti | -- | -- |
| Thiocta thioctic acid | -- | -- |
Lethathamo le ka holimo la li-analogues tsa lithethefatsi, tse bonts'ang Thiogammor, e loketse haholo hobane e na le sebopeho se tšoanang sa lintho tse sebetsang ebile e lumellana ho latela sesupo sa tšebeliso
Li-analoggs ka pontšo le mokhoa oa ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Lipin | -- | 230 UAH |
| Mummy Mummy | 20 rub | 15 UAH |
| Sefate sa litholoana sa Alder | 47 rub | 6 UAH |
| Placenta ntsa ea motho placenta ntsa | 1685 rub | 71 UAH |
| Lipalesa tsa Chamomile officinalis | 25 rub | 7 UAH |
| Litholoana tsa Rowan Rowan | 44 rub | -- |
| Lisahip Syrup | 29 rub | -- |
| Litholoana tsa Rosehip li matlafalitsoe sirapo | -- | -- |
| Lisa Hips | 30 rub | 9 UAH |
| Lehlabathe la Beroz Immortelle, Hypericum perforatum, Chamomile | -- | 4 UAH |
| Bioglobin-U Bioglobin-U | -- | -- |
| Pokello ea vithamini No. 2 Molora oa thaba, Rosehip | -- | -- |
| Gastricumel Argentum nitricum, Acidum arsenicosum, Pulsatilla pratensis, Stryhnos nux-vomiсa, Carbo herbsabilis, Stibium sulfuratum nigrum | 334 rub | 46 UAH |
| Motsoako oa lintho tse ngata tse sebetsang | -- | 12 UAH |
| Dalargin Biolik Dalargin | -- | -- |
| Dalargin-Farmsynthesis Dalargin | -- | 133 UAH |
| Tlosa motsoako oa lintho tse ngata tse sebetsang | -- | 17 UAH |
| Tai ea bana e nang le chamomile Althaea officinalis, Blackberry, Peppermint, Plantain lanceolate, Chamomile ea kalafo, licorice tsa Naked, Common thyme, Fennel e tloaelehileng, Hops | -- | -- |
| Bokelloa ba mmele ka har'a Hypericum perforatum, Calendula officinalis, Peppermint, Chamomile ea kalafo, Yarrow | 35 rub | 6 UAH |
| Kalgan cinquefoil e emong | -- | 9 UAH |
| Laminaria slani (sea kale) Laminaria | -- | -- |
| Lipin-Biolik lecithin | -- | 248 UAH |
| Moriamin Forte motswako oa lintho tse ngata tse sebetsang | -- | 208 UAH |
| Li-supplement tsa li-Buckthorn li-buckthorn | -- | 13 UAH |
| Phokotso ea kopanya lintho tse ngata tse sebetsang | -- | -- |
| Aronia chokeberry Aronia chokeberry | 68 rub | 16 UAH |
| Phekolo ea bongaka le pokello ea prophylactic No. 1 Valerian officinalis, Stinging nettle, Peppermint, Sowing oats, Large plantain, Chamomile, Chicory, Rosehip | -- | -- |
| Phekolo ea bongaka le pokello ea prophylactic No. 4 Hawthorn, Calendula officinalis, Flax tloaelehileng, Peppermint, Plantain e kholo, Chamomile, Yarrow, Hops | -- | -- |
| Phytogastrol e tloaelehileng, peppermint, chamomile ea kalafo, licorice hlobotse, dill e monko o monate | 36 rub | 20 UAH |
| Celandine joang Celandine e tloaelehileng | 26 rub | 5 UAH |
| Enkad Biolik Enkad | -- | -- |
| Gastroflox | -- | -- |
| Ho ntša Aloe | -- | 20 UAH |
| Orfadine Nitizinone | -- | 42907 UAH |
| Lesira la Miglustat | 155,000 rub | 80 100 UAH |
| Kuvan Sapropertin | 34 300 rub | 35741 UAH |
| Actovegin | 26 rub | 5 UAH |
| Apilak | 85 rub | 26 UAH |
| Hematogen albin lijo tse ntšo | 6 rub | 5 UAH |
| Elekasol Calendula officinalis, Chamomile officinalis, Naked licorice, tatellano ea Tripartite, Sage sa mori, Rod Eucalyptus | 56 rub | 9 UAH |
| Momordica compositum homeopathic potency ea lintho tse fapaneng | -- | 182 UAH |
| Tomoso ea Brewer's | 70 rub | -- |
| Plazmol ntsa ea mali a fanoeng | -- | 9 UAH |
| Mofuta oa Vitreous | 1700 rub | 12 UAH |
| Ubiquinone compositum homeopathic potency ea lintho tse fapaneng | 473 rub | 77 UAH |
| Galium Heel | -- | 28 UAH |
| Thyroididea Compositum homeopathic potency ea lintho tse fapaneng | 3600 rub | 109 UAH |
| Uridine uridine triacetate | -- | -- |
| Vistogard Uridine Triacetate | -- | -- |
Moetso o fapaneng o kanna oa lumellana ho bonts'a mokhoa le mokhoa oa kopo
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Immunofit Air tloaelehileng, Elecampane o molelele, Leuzea safflower, Dandelion, Naked licorice, Rosehip, Echinacea purpurea | -- | 15 UAH |
| Ectis Actinidia, Artichoke, Ascorbic Acid, Bromelain, Ginger, Inulin, Cranberry | -- | 103 UAH |
| Octamine Plus valine, isoleucine, leucine, lysine hydrochloride, methionine, threonine, tryptophan, phenylalanine, calcium pantothenate | -- | -- |
| E loketseng | -- | 74 UAH |
| Elkar Levocarnitine | 26 rub | 335 UAH |
| Carnitine levocarnitine | 426 rub | 635 UAH |
| Carnivitis Levocarnitine | -- | 156 UAH |
| Lecarnitol Lecarnitol | -- | 68 UAH |
| Stoator levocarnitine | -- | 178 UAH |
| Almba | -- | 220 UAH |
| Metacartin levocarnitine | -- | 217 UAH |
| Carniel | -- | -- |
| Cartan | -- | -- |
| Levocarnyl Levocarnitine | 241 rub | 570 UAH |
| Ademethionine Ademethionine | -- | -- |
| Heptor Ademethionine | 277 rub | 292 UAH |
| Heptral Ademethionine | 186 rub | 211 UAH |
| Adelion ademethionine | -- | 712 UAH |
| Hep Art Ademethionine | -- | 546 UAH |
| Hepamethione Ademethionine | -- | 287 UAH |
| Stimol citrulline malate | 26 rub | 10 UAH |
| Cerezyme tsohlelucerase | 67 000 rub | 56242 UAH |
| Ho hlahisoa agalsidase alpha | 168 rub | 86335 UAH |
| Fabrazim agalsidase beta | 158 000 rub | 28053 UAH |
| Aldurazim laronidase | 62 rub | 289798 UAH |
| Myozyme alglucosidase alpha | -- | -- |
| Mayozyme alglucosidase alpha | 49 600 rub | -- |
| Leihlo la Halsulfase | 75 200 rub | 64 646 UAH |
| Elaprase idursulfase | 131 000 rub | 115235 UAH |
| Vpriv velaglucerase alfa | 142 000 rub | 81 770 UAH |
| Eleliso Taliglucerase Alpha | -- | -- |
U ka fumana analogue e theko e tlaase ea ngaka e theko e phahameng?
Ho fumana analogue e theko e phahameng ea moriana, mofuta oa generic kapa lebitso, pele ho tsohle re khothaletsa ho ela hloko sebopeho, e leng lintho le lipontšo tse tšoanang tse sebetsang. Metsoako e tšoanang ea lithethefatsi e tla bonts'a hore lithethefatsi li tsamaisana le lithethefatsi, li ka lekana meriana kapa li ka etsa meriana. Leha ho le joalo, u se ke oa lebala ka likarolo tse sa sebetseng tsa lithethefatsi tse tšoanang, tse ka amang polokeho le ts'ebetso. Se ke la lebala ka litaelo tsa lingaka, ho itlama ho ka lematsa bophelo ba hau, ka hona, etela ngaka ea hau kamehla pele u sebelisa meriana leha e le efe.
Thupelo ea Tiogamma
TLOTLISO Ketso ea pharmacological Matšoao a ho sebelisoa Mokhoa oa kopo Melao ea tsamaiso ea batsoali ea Thiogamma-Turbo (Thiogamm) Tiogamma Litlamorao Contraindication Boimana Ho sebelisana le lithethefatsi Bongata Fomu ea tokollo Matlapa a Tiogamma Tharollo ea Thiogamma ea infusion Maemo a polokelo Sebopeho Sehlopha sa mahlale Boikhethelo Lipoic acid (matlapa) Tekanyetso: 42 Analogue e theko e tlase ho li-ruble tse 872. Lipoic acid ke ntho e theko e tlaase ka ho fetisisa ea Tiogamm ho sehlopha sa eona sa meriana. E fumaneha hape ka mokhoa oa matlapa a nang le litekanyetso tse fapaneng tsa DV. Matlapa a nang le litekanyetso tse fihlang ho 25 mg a beoa bakeng sa sebete sa mafura, lefu la sebete, lefu la sebete le sa foleng le ho tahoa. Analogue e theko e tlase ho li-ruble tse 586. Oktolipen - sethethefatsi se seng sa Russia, se leng molemo haholo ho feta "sa pele". Mona DV e tšoanang (thioctic acid) e sebelisoa ho litekanyetso tsa 300 mg ka motsotsoana. Matšoao a sebelisoang: lefu la tsoekere le tahi. Tialepta (matlapa) Tekanyetso: 29 holimo Analogue e theko e tlaase ho tloha li-ruble tse 548. Tiolepta ke sethethefatsi bakeng sa kalafo ea mafu a ka mpeng, ho ipapisitse le ketso ea thioctic acid e lekanang le meriana e meng e hlahisitsoeng leqepheng lena. E na le lethathamo le ts'oanang la matšoao a ho khethoa. Litlamorao li ka etsahala. Ha e nooa ka molomo, e kenella ka potlako 'me e kenelle ka ho phethahetseng mokhoeng oa ho sililoa, ho ja ka nako e tšoanang ka lijo ho fokotsa ho monya. Bioavailability ke 30-60% ka lebaka la phello ea karolo ea pele e kenang ka har'a sebete. Tmax hoo e ka bang metsotso e 30, Cmax - 4 μg / ml. Ka ho qala / ho kenngoa ha Tmax - metsotso e 10-11, Cmax e ka ba 20 μg / ml. E na le phello ea ho fetela ka har'a sebete. E tšeloa ka har'a sebete ka lehlakoreng le leng oxidation le conjugation. Tlhahiso ea plasma ka botlalo ke 10-15 ml / min. Thioctic acid le metabolites ea eona li hlahisoa ke liphio (80-90%), ka tekanyo e nyane - ha e fetohe. T1 / 2 - 25 mets. Tsepamisa maikutlo bakeng sa tharollo ea infusion le tharollo ea infusion Thiogamm Ka / ka, ka mokhoa oa infusions, o tsamaisoa butle butle (ho feta metsotso e 30) ka tekanyo ea 600 mg / ka letsatsi. Tsela e khothalletsoang ea ts'ebeliso ke libeke tse 2-5. Joale, o ka tsoela pele ho nka sebopeho sa molomo sa sehlahisoa sa Tiogamm ka tekanyo ea 600 mg / ka letsatsi. Vial e nang le tharollo ea infusion e tlosoa ka lebokoseng ebe e koaheloa hang-hang ka nyeoe e sirelelitsoeng ka bobebe, joalo ka thioctic acid e tsotella leseli. Ho kenella ho entsoe ka kotloloho ho tsoa vial. Sekhahla sa tsamaiso se batla se le 1,7 ml / min. Tharollo ea infusion e lokiselitsoe ho tsoa botebong ba pelo: litaba tsa ampoule e le 1 (e nang le 600 mg ea thioctic acid) li kopantsoe le 50-250 ml ea tharollo ea chloride ea 0,9%. Hang ka mor'a ho lokisa, botlolo e nang le tharollo ea infusion e koaheloa ka nyeoe e sireletsang leseli. Tharollo ea infusion e lokela ho fanoa hang ka mor'a ho itokisa. Nako e phahameng ea ho boloka tharollo e lokiselitsoeng ea infusion ha e fetise lihora tse 6 Li-litafole tse kopantsoeng tsa Thiogamma Ka hare, hanngoe ka letsatsi, ka mpeng e se nang letho, ntle le ho hlafuna le ho nooa ka metsi a manyane. Nako ea kalafo ke matsatsi a 30-60, ho latela boholo ba lefu lena. U ka pheta-pheta nako ea kalafo makhetlo a 2-3 ka selemo. Khafetsa ea liphetoho tse bohloko e bontšoa ho latela mokhathala oa WHO: khafetsa (ho feta 1/10), hangata (ka tlase ho 1/10, empa ho feta 1/100), haeba ho na le (ka tlase ho 1/100, empa ho feta 1/1000), ka seoelo (ka tlase ho 1/1000, empa ho feta 1/10000), ka seoelo (ka tlase ho 1/10000, ho kenyeletsoa linyeoe tse ikemetseng). Karolong ea hematopoietic system le lymphatic system: hempoint hemorrhages ka mucous membrane, letlalo, thrombocytopenia, thrombophlebitis - haholo ka seoelo (bakeng sa r-d / inf.), Thrombopathy - hangata haholo (bakeng sa conc. Bakeng sa r-d / inf.) hemorrhagic rash (purpura) - haholo ka seoelo (bakeng sa conc. bakeng sa r-ra d / inf. le r-ra d / inf.). Karolong ea boits'ireletso ba mmele: Liphetoho tsa systemic allergic (ho fihla ho nts'etsopele ea anaphylactic shock) ha li na seoelo (bakeng sa tafole), maemong a mang (bakeng sa ho fela. Bakeng sa r-d / inf. Le r-d / inf.). Ho tloha lehlakoreng la ts'ebetso ea methapo e bohareng: phetoho kapa tlolo ea methapo ea maikutlo ha e na seoelo (bakeng sa mefuta eohle), ho tsubella ha sethoathoa ho fumaneha ka seoelo (bakeng sa conc. Ho tloha lehlakoreng la setho sa pono: diplopia ha e fumanehe haholo (bakeng sa conc. Bakeng sa r-d / inf. Le r-d / inf.). Karolong ea letlalo le lisele tse potolohileng: litla-morao tsa letlalo (urticaria, ho hlohlona, eczema, rash) - ka seoelo (bakeng sa tafole), maemong a mang (bakeng sa ho fela. Bakeng sa r-ra d / inf. Le r-ra d / inf. .). Ho tsoa pampiring ea ka mpeng: ho nyekeloa, ho hlatsa, bohloko ba ka mpeng, lets'ollo - ka seoelo (bakeng sa tafole). Liphetoho tse ling tse mpe: karabelo ea allergic setsing sa ente (ho teneha, ho ruruha kapa ho ruruha) - ka seoelo (bakeng sa conc. Bakeng sa r-d / inf.), Maemong a mang (bakeng sa r-d / inf., Maemong a potlakileng Tsamaiso ea lithethefatsi e ka eketsa ICP (ho na le maikutlo a boima hloohong), ho hema ka thata (liphetoho tsena li itlhahela ka bo bona) - hangata (bakeng sa conc-r / d / inf.), ka seoelo (bakeng sa r-d / inf.), mabapi le ntlafatso ea tsoekere ea tsoekere, ho fokotseha ha tsoekere e maling maling hoa khoneha, 'me matšoao a hypoglycemia a ka hlaha (a hlobotse ho tsekela, ho fufuleloa ho eketsehileng, ho opeloa ke hlooho, ho ferekana hoa pono) - ka seoelo (bakeng sa conc. bakeng sa r-d / inf. le tafole), maemong a mang (bakeng sa r-d / inf.). Haeba efe kapa efe ea litla-morao tsena e mpefala kapa litla-morao tse ling tse sa thathamisitsoeng ho litaelo li hlaha, o lokela ho tsebisa ngaka ea hau. Ka tsamaiso e ts'oanang ea thioctic acid le sisplatin, ho fokotseha ho matlafala ha katleho ea cosplatin. Thioctic acid e tlama tšepe, ka hona ha ea lokela ho beoa ka nako e ts'oanang le litokisetso tse nang le li-ion tsa tšepe (mohlala, tšepe, magnesium, calcium). E ntlafatsa phello ea anti-inflammatory ea GCS. Ka tšebeliso e tšoanang ea thioctic acid le lithethefatsi tsa insulin kapa tsa molomo, matla a tsona a ka ntlafatsoa. Ethanol le metabolites ea eona e fokolisa phello ea thioctic acid. Ntle le moo ho tsepamisa mohopolo ho lokiseng tharollo ea infusion le tharollo ea infusion Thioctic acid e kopana le limolek'hule tsa tsoekere, e etsa li-solarle tse bonolo tse qhibilihang ka mohlala, ka tharollo ea levulose (fructose). Tharollo ea Thioctic acid infusion ha e lumellane le tharollo ea dextrose, Ringer le tharollo e arabelang ka li-disulfide le lihlopha tsa SH. Matšoao a bosholu ba lithethefatsi Tiogamma: ho nyekeloa ke pelo, ho hlatsa, hlooho. Tabeng ea ho nka tekanyetso ho tloha ho 10 ho isa ho 40 g ya thioctic acid hammoho le joala, linyeoe tsa ho tahoa li ile tsa bonoa ho fihlela sephetho se bolaeang. Matšoao a ho kula ho feta tekano: ho ferekana kelellong kapa ho hlohlona, hangata ho lateloang ke nts'etsopele ea ho ts'oaroa ka kakaretso le lactic acidosis. Ho boetse ho hlalositsoe maemo a hypoglycemia, ho thothomela, rhabdomyolysis, hemolysis, ho hasana kahare ho methapo ea mali, khatello ea maikutlo ea masapo le ho se sebetse hantle hoa litho tse ngata. Phekolo: matšoao. Ha ho na litlhare tse tobileng. Thiogamma - tsepamisa mohopolo ha ho etsoa tharollo ea infusion, 30 mg / ml. 20 ml li-ampoules tse entsoeng ka khalase e sootho (mofuta oa I). Ho tšeloa letheba le lesoeu ho e ngoe le e 'ngoe e nang le pente. Li-ampoule tse 5 li behiloe ka katareng ea karete ea karete le bafosi. Ho li-pallet tse 1, tse 2 kapa tse 4 hammoho le nyeoe e emisitsoeng e sirelletsang e bobebe e entsoeng ka PE e sootho, e kentsoeng lebokoseng la karete. Thiogamma - tharollo ea infusion, 12 mg / ml. 50 ml ka botlolong e entsoe ka khalase e sootho (mofuta oa II), e koetsoeng ka lithibelo tsa rabara. Li-plugs li entsoe ka ho sebelisa likhalase tsa aluminium, ka holimo moo ho nang le li-gaskets tsa polypropylene. Mabotlolo a 1 kapa a 10 a nang le linyeoe tse sirelletsang tse bobebe (ho latela palo ea libotlolo) tse entsoeng ka PE e ntso le likarolo tsa karete li kenngoa ka lebokoseng la karete. Thiogamma - matlapa a koahetsoeng, 600 mg. Matlapa a 10 marikeng a entsoe ka PVC / PVDC / foil ea aluminium. 3, 6, kapa marang-rang a behiloeng ka lebokoseng. 1 ampoule ea ho tsepamisa mohopolo ha ho etsoa tharollo ea infusion Tiogamma e na le ntho e sebetsang: meglumine thioctate 1167.7 mg (e lumellanang le 600 mg ea thioctic acid). Baeti: macrogol 300 - 4000 mg, meglumine - 6-18 mg, metsi bakeng sa ente - ho fihla ho 20 ml Botlolo e le 1 ea tharollo ea infogere ea Tiogamma e na le ntho e sebetsang: letsoai la meglumine ea thioctic acid 1167.7 mg (e lumellanang le 600 mg thioctic acid). Baeti: macrogol 300 - 4000 mg, meglumine, metsi a ente - ho fihlela 50 ml. 1 Letlapa le kopaneng la Thiogammar e na le ntho e sebetsang: thioctic acid 600 mg. Baeti: hypromellose - 25 mg, colloidal silicon diode - 25 mg, MCC - 49 mg, lactose monohydrate - 49 mg, sodium carmellose - 16 mg, talc - 36.364 mg, simethicone - 3.636 mg (dimethicone le silicon dioxide colloidal 94: 6 ), magnesium stearate - 16 mg, khetla: macrogol 6000 - 0,6 mg, hypromellose - 2.8 mg, talc - 2 mg, sodium lauryl sulfate - 0,025 mg. Bakuli ba nang le lefu la tsoekere ba hloka ho hlahlojoa khafetsa ka tsoekere ea mali, haholo-holo qalong. Maemong a mang, ho hlokahala ho fokotsa tekanyetso ea insulin kapa sethethefatsi sa hypoglycemic bakeng sa ho qoba nts'etsopele ea hypoglycemia. Haeba matšoao a hypoglycemia a etsahala (ho tsekela, ho fufuleloa, hlooho e bohloko, ho ferekana hoa pono, ho nyekeloa ke pelo), kalafo e lokela ho emisoa hanghang. Maemong a ikhethileng, ha u sebelisa lithethefatsi Tiogamm ho bakuli ba nang le taolo ea glycemic le ba maemong a tebileng a akaretsang, ho ka ba le karabelo e matla ea anaphylactic. Bakuli ba noang Thiogamma ba lokela ho hana ho noa joala. Ts'ebeliso ea lino tse tahang nakong ea kalafo le Tiogamma e fokotsa phello ea kalafo mme ke sesosa sa kotsi se tlatsetsang kholisong le tsoelo-peleng ea neuropathy. Ho susumetsa bokhoni ba ho khanna koloi kapa ho etsa mosebetsi o hlokang lebelo le eketsehileng la ho fetoha ha mmele le kelello. Ho nka Thiogamma ha ho ame bokhoni ba ho khanna koloi le ho sebetsa ka mekhoa e meng. Ntle le matlapa a koahetsoeng. Bakuli ba nang le ts'oaetso e sa tloaelehang ea lefutso ea fructose, tsoekere ea glucose-galactose malabsorption kapa khaello ea glucose-isomaltose ha ea lokela ho nka Tiogamma. Letlapa le le leng le koahetsoeng la Tiogamm 600 mg le na le tlase ho 0.0041 XE.
ka tšebeliso ea lithethefatsi
Tiogamma
Ntho e sebetsang ea Thiogamma (Thiogamm-Turbo) ke acid e bitsoang thioctic (alpha-lipoic). Thioctic acid e thehoa 'meleng' me e sebetsa e le coenzyme bakeng sa metabolism ea matla a alpha-keto acid ka oxidative decarboxylation. Thioctic acid e lebisa ho fokotseha ha tsoekere e ngata serumeng ea mali, e thusa ho bokella glycogen ho hepatocytes. Mathata a Metabolic kapa ho haella ha thioctic acid ho bonoa ka ho bokellana ho feteletseng ha metabolites e itseng 'meleng (mohlala,' mele oa ketone), hammoho le ts'ebeliso ea tahi. Sena se lebisa ho tsitsinyehong ho ketane ea aerobic glycolysis. Thioctic acid e teng 'meleng ka sebopeho sa mefuta e' meli: e fokotsehile ebile e na le oxidized. Mefuta eo ka bobeli e sebetsa 'meleng, e fana ka litlamorao tsa antioxidant le anti-toxic.
Thioctic acid e laola metabolism ea lik'habohaedreite le mafura, e ama hantle metabolism ea cholesterol, e na le phello ea hepatoprotective, e ntlafatsa ts'ebetso ea sebete. Tšusumetso e ntle lits'ebetsong tse iphetisang ho tishu le litho. Melemo ea pharmacological ea thioctic acid e ts'oana le litlamorao tsa livithamini tsa B. Nakong ea karolo ea pele ka sebete, acid ea thioctic e fetoha le liphetoho tse kholo. Ka mokhoa oa ho fumaneha hoa lithethefatsi, ho fokotseha hoa bohlokoa hoa motho ka mong hoa hlokomeleha.
Ha e sebelisoa kahare, e potlakile ebile e batla e amohuoa ka botlalo ho tsoa mohloling oa tšilo ea lijo. Metabolism e tsoela pele le oxidation ea lehlakore la lehlakore la thioctic acid le conjugation ea eona. Nako ea ho felisoa ha halofo ea bophelo ba Tiogamma (Tiogamm-Turbo) e tsoa metsotso e 10 ho isa ho e 20. Ho felisoa ka moroto, ka metabolites ea thioctic acid e ka pele.
Ka lefu la tsoekere la tsoekere ho ntlafatsa kutloisiso ea lisele.
Thiogamm-Turbo, Thiogamm bakeng sa tsamaiso ea batsoali
Thiogamm-Turbo (Thiogamma) e etselitsoe tsamaiso ea batsoali ka ho kenella ka hare ho marang-rang. Bakeng sa batho ba baholo, lethal dose ea 600 mg (litaba tsa 1 vial kapa 1 ampoule) e sebelisoa hang ka letsatsi. Ho kenella ho etsoa butle, bakeng sa metsotso e 20-30. Nako ea phekolo e nka libeke tse peli ho isa ho tse 'ne. Nakong e tlang, ho khothalletsoa ts'ebeliso ea kahare ea Tiogamma matlapeng. Tsamaiso ea botsoali ea Thiogamma-Turbo kapa Thiogamm bakeng sa infusion e laeloa bakeng sa mathata a matla a ho utloa bohloko a amanang le lefu la tsoekere.
Likahare tsa botlolo e le 'ngoe ea Thiogamma-Turbo kapa 1 ampoule ea Thiogamma (600 mg ea lithethefatsi) li qhibilihile ka 50-250 ml ea tharollo ea chloride ea 0,9%. Tekanyo ea infravenous infusion - eseng ho feta 50 mg ea thioctic acid ka motsotso o le mong - sena se lekana le 1,7 ml ea tharollo ea Tiogamma-Turbo (Tiogamma). Litokisetso tse hlapolotsoeng li lokela ho sebelisoa hang ka mor'a ho kopanya le solvent. Nakong ea infusion, tharollo e lokela ho sireletsoa leseli ke thepa e khethehileng e sireletsang leseli.
Matlapa a etselitsoe ho sebelisoa kahare. Ho khothalletsoa ho fana ka 600 mg ea moriana o 1 ka letsatsi. Letlapa le lokela ho metsoa le felle, ho sa natsoe lijo, le hlatsuoe ka metsi a lekaneng. Nako ea kalafo ea pilisi e tsoa ho likhoeli tse 1 ho isa ho tse 'ne.
Tsamaiso ea methapo e bohareng: maemong a sa tloaelehang, hang hang ka mor'a tšebeliso ea lithethefatsi ka mokhoa oa ho kenella, ho ka khoneha hore ho be le meroalo e matla ea mesifa.
Litho tsa kutlo: tlolo ea maikutlo a tatso, diplopia.
Sisteme ea Hematopoietic: purpura (hemorrhagic rash), thrombophlebitis.
Boitšoaro ba Hypersensitivity: Boits'oaro bo hlophisehileng bo ka baka ho ts'oaroa ha anaphylactic, eczema kapa urticaria sebakeng sa ente.
Sistimi ea digestive (bakeng sa matlapa a Tiogamma): lipontšo tsa dyspeptic.
Tse ling: haeba Thiogamm-Turbo (kapa Thiogamm bakeng sa tsamaiso ea batsoali) e tsamaisoa ka potlako, khatello ea maikutlo le moea oa ho thatafala sebakeng sa hlooho li ka khonahala - litla-morao tsena li emisa kamora ho fokotseha ha sekhahla sa infusion. Hape ho ka etsahala: hypoglycemia, ho chesa, ho ts'oenyeha, ho ruruha, ho utloa bohloko ka pelong, ho fokotsa tsoekere ea mali, ho nyekeloa, pono e ferekanyang, hlooho, ho hlatsa, tachycardia.
• Maemo a mamello a qholotsa nts'etsopele ea lactic acidosis (bakeng sa Thiogamma-Turbo kapa Thiogamm bakeng sa tsamaiso ea batsoali),
• lilemo tsa bana,
• Nako ea kemaro le pelehi,
• karabelo ea ho hloaelana le thioctic acid kapa likarolo tse ling tsa Thiogamm (Thiogamma-Turbo),
• ho senyeha haholo kapa lefu la ho fokola ha masapo,
• sethala se matla sa lefu la myocardial,
• Koetliso e ntlafalitsoeng ea ho phefumoloha kapa pelo,
• ho omella,
• Joala bo sa feleng
• kotsi ea methapo ea methapo ea pelo.
Nakong ea bokhachane kapa nakong ea kanyeso, tšebeliso ea Thiogamma le Thiogamm-Turbo ha e khothalletsoe, kaha ha ho na boiphihlelo bo lekaneng ba kliniki ka meriana e fanoang.
Ho sebetsa ha lithethefatsi tsa hypoglycemic le insulin ho eketsoa hammoho le Thiogamma (Thiogamma-Turbo). Tharollo ea Thiogamm-Turbo kapa Thiogamm ha e lumellane le solvent e nang le limolek'hule tsa glucose, kaha thioctic acid e baka metsoako e rarahaneng ea tsoekere. Litekong tsa vitro, asiti ea thioctic e ile ea sebetsana le li-ion complexes tsa tšepe. Mohlala, motsoako o nang le cosplantine, magnesium le tšepe o ka fokotsa phello ea morao ha e kopantsoe le thioctic acid. Li-solvents tse nang le lintho tse kopantsoeng le li-compact tsa disulfide kapa lihlopha tsa SH ha li sebelisoe ho hlapolla tharollo ea Thiogamma-Turbo (Thiogamma) (mohlala, tharollo ea Ringer).
Ka overdose ea Tiogamma (Tiogamm-Turbo), hlooho e bohloko, ho hlatsa le ho nyekeloa hoa pelo ho khonahala. Phekolo ke letšoao.
Tiogamm Turbo
Tharollo bakeng sa infusion ea batsoali ho li-vials tse 50 ml (1,2% thioctic acid). Ka sephutheloaneng - 1, libotlolo tse 10. Ho kenyelelitsoe linyeoe tse khethehileng tsa lebone la motlakase.
Matlapa a koahetsoeng ka 600 mg bakeng sa tšebeliso ea kahare. Ka paketeng ea matlapa a 30, 60.
Tharollo ea tsamaiso ea botsoali ka li-ampoules tsa 20 ml (3% thioctic acid). Ka har'a sephutheloana - li-ampoules tse 5.
Sebakeng se sirelelitsoeng leseli, ka mocheso oa likhato tse 15 ho isa ho tse 30 tsa Celsius. Tharollo e lokiselitsoeng ho kenella kahare ha e na poloko. Ampoules le lipompo li lokela ho ba liphuthehong tsa pele feela.
Tiogamm Turbo
Lintho tse sebetsang (ka 50 ml): thioctic acid 600 mg.
Lintho tse ling: metsi a ente, macrogol 300.
50 ml ea tharollo ea tlheketso ea Tiogamma-Turbo e na le letsoai la meglumine la alpha-lipoic acid ka tekanyo ea 1167.7 mg, e lumellanang le 600 mg ea thioctic acid.
Tiogamma
Lintho tse sebetsang (ka har'a letlapa le le leng): thioctic acid 600 mg.
Lintho tse ling: colloidal silicon dioxide, cellcose ea microcrystalline, talc, lactose, methylhydroxypropyl cellulose.
Tiogamma
Lintho tse sebetsang (ka 20 ml): thioctic acid 600 mg.
Lintho tse ling: metsi a ente, macrogol 300.
20ml ea tharollo ea inflants ea Tiogamma e na le meglumine letsoai la alpha-lipoic acid ka tekanyo ea 1167.7 mg, e lumellanang le 600 mg ea thioctic acid.
Lihormone, li-analogues tsa bona le lithethefatsi tsa antihormonal
Lithethefatsi tse thehiloeng ho li-pancreatic le lithethefatsi tse entsoeng ka hypoglycemic
Synthetic hypoglycemic agents
Ntho e sebetsang: Thioctic asiti
Ka botlolong e nang le Thiogamma-Turbo e qhibilihileng, ho beoa linyeoe tse khethehileng tse sireletsang khanya, tse tlameletsoeng morianeng. Tharollo ea Thiogamm e sirelelitsoe ka lisebelisoa tse sireletsang. Phekolo ea bakuli, litekanyetso tsa tsoekere ea serum li lokela ho lekanngoa khafetsa, ho latela hore na litekanyetso tsa li-insulin le lithethefatsi tsa hypoglycemic li lokela ho fetoloa ho qoba hypoglycemia. Ts'ebetso ea kalafo ea thioctic acid e fokotsehile haholo ka tšebeliso ea joala (ethanol). Ha ho na litemoso tse ling tsa bohlokoa.Li-Substitutes tse fumanehang tsa Thiogamma
Mofumahali
Mokhoa oa kopo
Litlamorao
Ho sebelisana le lithethefatsi tse ling
Bongata
Fomu ea tokollo
Boikhethelo
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Sesosa se kotsi
Seketsoana sa thibelo ke eng? Jaundice e nang le phepo e ntle ke lefu la tlhaho le amanang le tlolo ea leqhubu la hepatic bile le kenella ka hare ho li-duodenum ka lebaka la tšitiso ea mochine. ... -
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