Thioctacid 600 t: litaelo tsa tšebeliso

Tekanyetso e le 'ngoe ea tharollo e na le:

Ntho e sebetsang: 952.3 mg ea trometamol letsoai la thioctic acid (ho latela thioctic (a-lipoic acid) - 600.0 mg).

Baeti: trometamol, metsi bakeng sa ente.

Tharollo ea 'mala o mosehla oa' mala o mosehla.

Ketso ea pharmacological

Alpha-lipoic (thioctic) asiti ke ntho e kang vithamine e nang le thepa ea coenzyme. E thehoa 'meleng nakong ea oxidative decarboxylation ea alpha-keto acid.

Ho tsoekere ea lefu la tsoekere ka lebaka la hyperglycemia, litaba tsa lihlahisoa tsa ho qetela tsa glycosylation lia eketseha. Ts'ebetso ena e lebisa ho fokotseha ha phallo ea mali a endoneural le nts'etsopele ea endoneural hypoxia. Ka nako e ts'oanang, hammoho le keketseho ea ho etsoa ha li-radicals tsa mahala, litaba tsa li-antioxidants, haholo, glutathione, lia fokotseha.

Alpha-lipoic (thioctic) asiti ke ntho e kang vithamine e nang le thepa ea coenzyme. Ka 'mele, e thehoa nakong ea li-oxidative decarboxylation tsa alpha-keto acid.

Ho tsoekere ea lefu la tsoekere ka lebaka la hyperglycemia, litaba tsa lihlahisoa tsa ho qetela tsa glycosylation lia eketseha. Ts'ebetso ena e lebisa ho fokotseha ha phallo ea mali a endoneural le nts'etsopele ea endoneural hypoxia. Ka nako e ts'oanang, hammoho le keketseho ea ho etsoa ha li-radicals tsa mahala, litaba tsa li-antioxidants, haholo, glutathione, lia fokotseha.

Lithutong tsa liteko tse entsoeng ho likhoto, ho ile ha bontšoa hore alpha-lipoic acid e fokotsa ho theoa ha lihlahisoa tsa glycosylation, e ntlafatsa phallo ea mali a endoneural, le ho eketsa maemo a glutathione. Lintlha tsena li fana ka maikutlo a hore alpha lipoic acid e ka kenya letsoho ho ntlafatsa ts'ebetso ea methapo ea kutlo. Sena se sebetsa le lits'oants'o tsa methapo ea kutlo ho lefu la tsoekere la polyneuropathy, joalo ka dysesthesia, paresthesia (ho chesa, bohloko, ho akheha, ho tsikinyeha). Lithutong tsa bongaka ho bakuli ba nang le lefu la tsoekere la polyneuropathy, tsamaiso ea alpha-lipoic acid e lebisitse ho fokotseha hoa mathata a methapo a tsamaeang le lefu la tsoekere la polyneuropathy (bohloko, paresthesia, dysesthesia, botenya).

Bokhachane le pelehi

Lintlha tse fumanehang ka litlamorao tsa chefo ho tsoalo ha li fane ka monyetla oa ho fihlela liqeto mabapi le litlamorao tse kotsi ho lesea. Ka lebaka la khaello ea tlhahlobo e lekaneng ea kliniki, moriana ha o khothalletsoe ho basali nakong ea kemolo.

Ha ho tsejoe hore na thioctic (a-lipoic) acid e fetela lebeseng la matsoele. Haeba ho hlokahala ho sebelisa moriana nakong ea matsoele, ho anyesa ho lokela ho emisoa.

Tekanyetso le tsamaiso

Tekanyetso ea letsatsi le letsatsi qalong ea kalafo e nang le methapo e meholo ea kutloisiso ho lefu la tsoekere e matla ea lefu la tsoekere ke 1 ampoule ea Thioctacid 600 T (e lumellanang le 600 mg ea thioctic acid) bakeng sa libeke tsa 2-4.

Thioctacid 600 T e ka sebelisoa e le tlhahiso ea tharollo ea isotonic sodium chloride (infusion volume 100-250 ml) metsotso e 30. Tsamaiso ea methapo e lokela ho etsoa butle (eseng ka potlako ho feta 50 mg ea thioctic acid, i.e. 2 ml ea tharollo ea Thioctacid 600 T ka motsotso). Ntle le moo, ts'ebetso ea methapo ea tharollo e sa kenngoeng letho e ka khoneha ka sindano ea ente kapa perfuser. Maemong ana, nako ea tsamaiso e lokela ho ba bonyane metsotso e 12.

Tataiso ea Tlatsetso

Ka lebaka la bosholu ba ntho e sebetsang ho bonesa, li-ampoules li lokela ho tlosoa mokatong oa karete ea karete hang hang pele li sebelisoa. Ka mokhoa oa solvent bakeng sa tharollo ea infusion ea Thioctacid 600 T, sebelisa feela tharollo ea isotonic sodium chloride. Tharollo ea infusion e lokela ho sireletsoa leseli (mohlala, ho foil ea aluminium). Tharollo ea infusion, e sirelelitsoeng ho khanya, e loketse lihora tse 6.

Kamora nako, ba fetohela ho pheko ea tlhokomelo le mefuta ea litekanyetso tsa a-lipoic acid bakeng sa tsamaiso ea molomo ka tekanyetso ea 300-600 mg ka letsatsi.

Motheo oa kalafo ea lefu la tsoekere la polyneuropathy ke kalafo e nepahetseng bakeng sa lefu la tsoekere.

Bongata

Haeba ho na le bongoana bo feteletseng, ho nyekeloa le pelo, ho hlatsa le hlooho e ka hlaha. Kamora ho nooa ka boomo kapa ka boomo (ho ipolaea) ka alpha-lipoic acid ka tekanyetso ea 10 ho isa ho 40 g ka joala, ho tahoa haholo ho ile ha bonoa, ka linako tse ling ka phello e bolaeang. Matšoao a Clinical a tahi a ka hlaha ka mokhoa oa ho ferekanya kelellong kapa ho ferekanya, nakong e tlang hangata a tsamaisana le ho ts'oaroa ka mokhoa o phollatsi le nts'etsopele ea lactic acidosis. Ntle le moo, ka lebaka la tahi e nang le tekanyetso e phahameng ea alpha-lipoic acid, hypoglycemia, ho tsitsipana, rhabdomyolysis, hemolysis, tsamaiso ea methapo ea methapo (DIC), khatello ea ts'ebetso ea masapo le masapo a mangata a litho tse ngata li ile tsa hlokomeloa.

Leha a belaela hanyane ka bokhoba ba tahi, Thioctacid e bonts'a ho kena sepetlele hanghang ka mekhoa ea phekolo ka kakaretso Molemong oa kalafo ea ho ts'oaroa ka mokhoa o akaretsang, lactic acidosis le litlamorao tse ling tsohle tse behang bophelo kotsing ea ho tahoa, ho hlokahala kalafo ea matšoao. Ho fihla joale, katleho ea hemodialysis le extracorporeal detoxification mekhoa ea ho potlakisa tlhahiso ea alpha-lipoic acid ha e so netefatsoe.

Ho sebelisana le lithethefatsi tse ling

Ka tsamaiso e tšoanang ea Thioctacid 600 T, ho fokotsehile ho fokola hoa katleho ea cosplatin. Thioctacid 600 T e tlama tšepe le litokisetso tse nang le tšepe (mohlala, tšepe, magnesium, lihlahisoa tsa lebese tse nang le calcium).

Ka tšebeliso e ts'oanang, ts'ebetso e fokotsang tsoekere ea lithethefatsi tsa insulin le antidiabetic bakeng sa tsamaiso ea molomo e ka matlafatsoa, ​​ka hona, ho lekola khafetsa maemo a tsoekere ea mali, haholoholo qalong ea kalafo le Thioctacid 600 T, ho khothalletsoa. mading).

Alpha lipoic acid e fetoha ka har'a vitro e nang le likarolo tsa tšepe tsa ionic (mohlala, lisplatin). Alpha-lipoic acid e bopa mebala e sa sebetseng hantle e nang le limolek'hule tsa tsoekere. Thioctacid 600 T ha e lumellane le tharollo ea dextrose, tharollo ea Ringer, le tharollo e arabelang ka lihlopha tsa disulfide kapa tsa SH.

E le solvent bakeng sa lithethefatsi Thioctacid 600 T, ke tharollo ea isotonic sodium chloride feela e ka sebelisoang.

Litlhokahalo tsa polokeho

Tšebeliso ea joala e sa khaotseng ke sesosa sa kotsi bakeng sa nts'etsopele ea polyneuropathy mme e ka fokotsa ts'ebetso ea Thioctacid 600 T. Ka hona, bakuli ba eletsoa hore ba hane ho noa lino tse tahang nakong ea kalafo le sethethefatsi le nakong ea kalafo.

Ka tsamaiso e kenelletseng ea litokisetso tsa a-lipoic acid, maikutlo a amanang le hypersensitivity a ile a tlalehoa, ho kenyelletsa ho makala ha anaphylactic (bona karolo ea "Litlamorao"). Nakong ea kalafo, ho lekola mokuli kamehla hoa hlokahala. Maemong a matšoao (mohlala, ho hlohlona, ​​ho nyekeloa, malaise, joalo-joalo), tsamaiso ea lithethefatsi e lokela ho emisoa hanghang mme kalafo e eketsehileng ea lithethefatsi e lokela ho khethoa haeba ho hlokahala.

Kamora ho sebelisa moriana Thioctacid 600 T, phetoho ea monko oa moroto oa khonahala, e senang bohlokoa ba tleliniki.