Zanocin ea lithethefatsi: litaelo tsa tšebeliso

Zanocin e fumaneha ka mefuta e latelang ea litekanyetso:

Tharollo ea infusion (100 ml ka libotlolong, botlolo e le 'ngoe ka lebokoseng la karete),
Matlapa, a koahetsoeng kapa a koahetsoeng ka filimi (li-pcs tse 10.).

Sebopeho sa 1 letlapa le 100 ml ea tharollo ea infusion e kenyelletsa ntho e sebetsang: ofloxacin - 200 mg.

Mofumahali

Ofloxacin, motsoako o sebetsang oa lithethefatsi, ke moemeli oa litheko tse akaretsang tsa karolo e akaretsang ea karolo ea sehlopha sa fluoroquinolone. E sebetsa ho "encyme" ea baktheria ea DNA ea baktheria, e ikarabellang ho supercoiling, mme, ka hona, e fetola botsitso ba DNA ea li-microorganisms (ho ts'oaroa ha liketane tsa DNA ho bakang lefu la bona). Ntho ena e boetse e na le phello ea bactericidal.

Ofloxacin e loana le likokoana-hloko tse latelang:

Anaerobes: Clostridium perfringens,
Li-aerobes tsa Gram-negative: Serratia marcescens, Acinetobacter calcoaceticus, Pseudomonas aeruginosa (e qala ho hanyetsana), Bordetella pertussis, Providencia stuartii, Providencia rettgeri, Citrobacter koseri, Citrobacter freundii, Proteus vulgareroeroeroberoeroberoeroberoeroberoeroberoeroberoeroberoeroberoeroberioo oa patrobacteroeroberooeroberooo oa lere le. Klebsiella pneumoniae, Klebsiella oxytoca, Haemophilus influenzae, Haemophilus ducreyi, Morganella morganii, Moraxella catarrhalis,
li-aerobes tse nang le gram tse ntle: Streptococcus pyogene, Streptococcus pneumoniae (likarolo tse tebileng tsa penicillin), Staphylococcus saprophyticus, Staphylococcus epidermidis (methicillin-oblique strains), Staphylococcus aureus (methicillin-sensatives
ba bang: Ureaplasma urealyticum, Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Legionella pneumophila, Gardnerella vaginalis.

Maemong a mangata, ho hanyetsoa ha inloxacin ho bontšoa ke Treponema pallidum, Nocardia asteroides, boholo ba mefuta ea Streptococcus spp., Enterococcus spp., Bacteria ea Anaerobic (ho kenyeletsoa Clostridium Hardile, Bacteroides spp. .

Mofumahali

Kamora ho tsamaisoa ka molomo, ofloxacin e kenngoa ka potlako mme e batla e le ka botlalo (hoo e ka bang 95%). Bioavailability e feta 96%, mme tekanyo ea ho tlama liprotheine tsa plasma ke 25%. Ha e tsamaisoa, phello e phahameng ea ntho e fumaneha ka mor'a lihora tse 1-2 le ka mor'a ho tsamaisoa ka tekanyetso ea 200 mg, 400 mg le 600 mg e lekana le 2,5 μg / ml, 5 μg / ml le 6.9 μg / ml, ka ho latellana.

Ho ja ho ka fokotsa sekhahla sa karolo ea Zanocin e sebetsang, empa ha ho ame haholo ts'ebetso ea eona ea bioavailability.

Kamora ho kenella ka kotloloho e le 'ngoe ea 200 mg ofloxacin, e nkang metsotso e 60, karolelano e phahameng ea plasma ea ntho ke 2,7 μg / ml. Lihora tse 12 kamora tsamaiso, boleng ba eona bo theohela ho 0.3 μg / ml. Ho tsepamisa mohopolo ka tekano ho fihlelleha feela kamora ho hlahisoa ha bonyane litekanyetso tse 4 tsa Zanocin. Litekanyetso tse tlase le tse phahameng tsa tekano li fihlelloa kamora ho kenella kahare ho tsamaiso ea ofloxacin lihora tse ling le tse ling tse 12 bakeng sa matsatsi a 7 mme ke 0.5 le 2.9 μg / ml, ka ho latellana.

Bophahamo bo bonahalang ba thomello bo fihla ho lilithara tse 100. Ofloxacin e tsamaisoa hantle ka holim'a litho le lisele tsa 'mele, e kenella ka hare ho secretion ea tšoelesa ea senya, lisele (alveolar macrophages, leukocytes), bile, sesepa, moroto, letlalo, sistimi ea phefumoloho, masapo, lisele tse bonolo, litho tsa kahare le mpa. Sesebelisoa se hlola habonolo khatello ea mali le methapo ea mali, se qheleloa ka lebeseng 'me se shebelloa mokelikeli oa "cerebrospinal fluid" (14-60% ea lethal dose).

Metabolism ea Ofloxacin e etsoa ka har'a sebete (ho fihlela ho 5% ea lithethefatsi tse tlisoang ke biotransformation), mme metabolites ea mantlha ke demethylofloxacin le ofloxacin-N-oxide. Nako ea bophelo ba ho felisoa e fapana ho tloha lihora tse 4,5 ho isa ho tse 7 'me ha e ea itšetleha ka tekanyetso. K'honthinente e qheletsoe ka har'a moroto - ho fihlela 75-90% e sa fetohe, hoo e ka bang 4% ealoloacacin e hloekisoa kahare. Tlhahiso e eketsehileng ha e fetise 20%. Kamora ho kenngoa ka lethekeng le le leng la moriana ka tekanyetso ea 200 mg, ofloxacin e ikemiselitsoe ka har'a moroto bakeng sa lihora tse 20-25.

Bakeng sa bakuli ba nang le ho hloleha hoa hepatic kapa renal, tekanyo ea ho felisoa haloxacin e kanna ea tsamaea butle. Cumulation ea ntho e 'meleng ha e eo. Nakong ea ts'ebetso ea hemodialysis, ho fihla ho 10-30% ea ntho e sebetsang Zanocin e qotsitsoe.

Matšoao a ho sebelisoa

Ts'oaetso: pampitšana ea urinary, gynecological (ho kenyelletsa le lefu la tsoekere, chlamydia), litho tsa ENT, phepelo ea matšoafo, litho tsa pono, lisele tse bonolo le letlalo, pampitšana ea gastrointestinal,
Endocarditis
Lefuba (e le karolo ea kalafo e kopaneng joaloka sethethefatsi sa mola oa bobeli),
Bacteremia.

Litaelo tsa ho sebelisa Zanocin: mokhoa le litekanyetso

Tekanyo ea Zanocin e khethoa ka bonngoe.

Lithethefatsi ka mokhoa oa litafole li nooa ka molomo. Mokhoa oa kopo o khethoa ke matšoao:

Ts'oaetso ea kahare le ts'oaetso e sa rarahanang ea moroto: makhetlo a 2 ka letsatsi, 200 mg ka 'ngoe,
Tšoaetso ea etiology e fapaneng: makhetlo a 2 ka letsatsi, 200-400 mg,
Chlamydia: makhetlo a 2 ka letsatsi, 300-400 mg ka matsatsi a 7-10,
Prostatitis e bakoang ke E. coli: makhetlo a 2 ka letsatsi, 300 mg ka 'ngoe (ho fihlela libeke tse 6),
Kokonate e sa sebetseng habonolo: hang 400 mg.

Zanocin ka mokhoa oa tharollo ea infusion e sebelisoa kahare, mokelikeli, infusion. Hangata lithethefatsi li fanoa:

Tšoaetso ea pampitšana ea urinary: makhetlo a 2 ka letsatsi, 200 mg ka 'ngoe,
Ts'oaetso ea Intraabdominal, tšoaetso ea lisele tse bonolo, letlalo, pampitšana ea phefumoloho: makhetlo a 2 ka letsatsi, 200-400 mg.

Litlamorao

Nakong ea kalafo, litlamorao tse latelang li ka hlaha:

Tsamaiso ea methapo e bohareng: bofokoli, ho tsekela, tšitiso ea boroko, hlooho e bohloko, Photophobia,
Sistimi ea tšilo ea lijo: ho se sebetse hantle ka mpeng, ho nyekeloa ke pelo, lets'ollo, ho hlatsa, ho ipolaisa tlala,
Boitlhotlhollo: Ho feberu, ho ruruha, ho ruruha, ho hlohlona.

Bongata

Matšoao a bosholu ba Zanocin ke: ho lelefatsa nako ea QT, ho tsekela, ho otsela, ho ferekanya kelello, ho ferekana, ho ferekanya, ho hlatsa. Tabeng ena, ho kgothaletswa kalafo e tsoang ka mpeng le kalafo ea matšoao. Ka nako e telele ea nako ea QT, ho ka hlokahala leihlo la ECG kamehla.

Ho sebelisana le lithethefatsi

Kameho ea ts'ebeliso ea Zanocin e fokotsa li-antacids (ho koaloa ha inhibit).

Maemong a mang, Zanocin e ka eketsa maemo a theophylline ho plasma.

Litšoantšiso tsa Zanocin ke: Dancil, Zoflox, Tarivid, Ofloxacin, Ofloxacin Zentiva, Ofloxacin-Teva, Ofloxacin Protekh, Ofloxin, Uniflox, Phloxal.

Litlhahlobo mabapi le Zanocin

Ho latela maikutlo, Zanocin e tloaetse ho fuoa bakuli e le karolo ea kalafo ea metroneteetritis, perimetritis le salpingoophoritis, hammoho le mafu a mang a urological le gynecological. Ho latela litsebi, kalafo e ile ea sebetsa haholo 'me ea utloahala, kaha ofloxacin e sebetsa hantle ho basebelisi ba mafu ana. Boholo ba bakuli ba ne ba mamella kalafo hantle, ke karolo e nyane feela ea bona e neng e na le karabelo e fapaneng ea lets'ollo, ho nyekeloa le pelo le boits'its'oaro, hammoho le lipontšo tsa photosensitivity nakong ea kalafo le Zanocin nakong e futhumetseng.

Ofloxacin e sirelitsoe ka liphio, e leng se u lumellang ho phekola ka katleho lits'oaetso tsa ts'oaetso tse tsamaeang le mafu a urological. Hona joale ka letsatsi la bo77 kamora ho qala kalafo, bacteriuria ea nyamela mme bophelo ba bakuli ka kakaretso boa ntlafala. Litlamorao ha li na seoelo.

Zanocin e ka sebelisoa hape ho phekola mafu a tšoaetsanoang a bakoang ke Escherichia coli le pseudomonas. Hape, e na le phello e matlafatsang. Ka hona, lingaka hangata li fana ka eona bakeng sa kalafo ea AIDS le mofets'e, kaha maemo a joalo a tšoauoa ka ho fokola hoa mmele.

Melemo ea litheko tsa lithethefatsi Zanocin

Mofumahali Ofloxacin ((±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido1,2,3-de-1,4- benzoxazine-6-carboxylic acid) ke moemeli oa antimicrobial oa sehlopha sa fluoroquinolone. Matla a bactericidal aloloacacin, joalo ka li-quinolones tse ling tse nang le mocheso, e bakoa ke bokhoni ba eona ba ho thibela bacteric encyme ea DNA gyrase.
Boholo ba antibacterial ea lithethefatsi bo koahela likokoana-hloko tse loantšang penicillin, aminoglycosides, cephalosporins, le likokoana-hloko tse nang le ho hanyetsa hangata.
Zanocin OD - setlhare se nang le tokollo ea nako e telele ea ntho e sebetsang - ofloxacin. Moriana o nooa hanngoe ka letsatsi. Letlapa le le leng la Zanocin OD 400 kapa 800 mg, le nooa hang ka letsatsi, le fana ka phello ea kalafo e lekanang le ho nka matlapa a 2 a tloaelehileng aloxacin 200 le 400 mg, ka ho latellana, a nooa makhetlo a mabeli ka letsatsi.
Zanocin ka sebopeho sa letlhare e sebetsa khahlano le libaktheria tse fapaneng.
Libaktheria tse mpe tsa aerobic: E. coli, Klebsiella spp., Salmonella spp., Proteus spp., Shigella spp., Yersinia spp., Enterobacter spp., Morganella morganii, Providencia spp., Vibrio spp., Citrobacter spp., Serratia spp. , Pseudomonas aeruginosa, P. cepacia, Neisseria gonorrhoeae, N. meningitidis, Haemophilus influenzae, H. ducreyi, Acinetobacter spp., Moraxella catarrhalis, Gardnerella vaginalis, Pasteurella multocida, Helicobacter pyl. Mefuta e fapaneng ea lithethefatsi e na le lits'oants'o. Brucella melitensis.
Baktheria e ntle ea gram e ntle: staphylococci, ho kenyelletsa penicillinase e hlahisang mefuta, le mafu a hangoang ke methicillin, streptococci (haholo-holo Streptococcus pneumoniae), Listeria monocytogenes, Corynebacterium spp.
Ofloxacin e sebetsa haholo ho feta ciprofloxacin kamanong le Chlamydia trachomatis. E sebetsa hape khahlanong le Mycobacterium leprae le Lefuba la Mycobacterium le mefuta e meng Mycobacterium. Ho na le litlaleho tsa phello ea synergistic ealoloacacin le rifabutin mabapi le M. leprae.
Treponema pallidum, livaerase, li-fungus le protozoa ha li na taba le ofloxacin.
Mofumahali Setlhare sena se potlakile ebile se batla se kenelle ka botlalo mokhoeng oa ho silila. Bioavailability e felletseng ea ofloxacin ke 96% ka mor'a taolo ea molomo. Ts'oarello ea plasma ea mali e fihla ho 3-4 /g / ml ka mor'a lihora tse 1-2 ka mor'a taolo ka tekanyetso ea 400 mg. Ho ja ha ho fokotse ho kenella ha makhopho aloxacin, empa ho ka fokotsa lebelo la ho monya. Bophelo ba halofo ea lithethefatsi ke lihora tse 5-8. Hobane li-andloxacin li hlahisoa haholo ke liphio, li-pharmacokinetics tsa tsona li fetoha haholo ho bakuli ba nang le ts'ebetso ea renal function (clearinine clearance ≤50 ml / min) mme ka hona ba hloka tokiso ea tekanyetso.
Hemodialysis e fokotsa hanyane khatello ealoxacin maling a mali. Ofloxacin e ajoa haholo lithaoleng le maro a 'mele, ho kenyeletsoa CSF, bophahamo ba kabo ea thepa bo tsoa ho 1 ho isa ho 2,5 l / kg. Hoo e ka bang 25% ea lithethefatsi li tlama ho protheine ea plasma. Ofloxacin e feta ka har'a placenta le ho kena lebese la matsoele. E fihla botebong ba linama tse ngata le maro a 'mele, ho kenyelletsa le ascites, bile, mate, secretion ea bronchial, lesapo la nyooko, matšoafo, tšoelesa ea senya.
Ofloxacin e na le selikalikoe sa pyridobenzoxazine, se fokotsang sekhahla sa metabolic ea motsoako oa motsoali. Setlhare sena se tlosoa ka bongata ka har'a moroto o sa fetoheng, 'moho le 65-80% ka nako ea lihora tse 24- 48. Tlas'a 5% ea lethal dose e ntšoa ka har'a moroto ka mokhoa oa dimethyl kapa N-oxide metabolites. 4-8% ea lethal dose e nkuoeng e hlobolisoa mantle. Bongata bo bonyenyane ba peoxacin bo qheleloa kahare.
Ho ne ho se na phapang ea boholo ba karolelano ea moriana ho batho ba baholo, sethethefatsi se hlahisoa haholo ke liphio ka sebopeho se sa fetoheng, leha ho le joalo ka tekanyo e tlase. Kaha ofloxacin e pateloa haholo ke liphio, 'me ho bakuli ba tsofetseng, ts'ebetso ea kutlo e sa sebetseng hantle hangata e lemohuoa, litekanyetso tsa lithethefatsi li lokisoa bakeng sa ts'ebetso ea ho hlaka ea renal, joalo ka ha e khothaletsoe bakuli bohle.
Pharmacokinetics of Zanocin OD kenya letsoho ts'ebelisong ea eona. Lijo ha li ame tekanyo ea ho amoheloa ha moriana joalo. Matlapa a nako e telele aloxacin a kenella ka potlako mme a na le monko o phahameng ho feta ha o bapisoa le matlapa a tloaelehileng a "loxacin "a nkoang makhetlo a mabeli ka letsatsi. Kamora ho tsamaisoa ha molomo oa Zanocin OD 400 mg, palo e phahameng ea andloxacin ka plasma ea mali e fihlelloa kamora lihora tse 6.778 ± 3.154 mme ke 1.9088 μg / ml ± 0.46588 μg / ml. AUC0-11 ke 21.9907 ± 4.60537 μg • g / ml. Kamora ho tsamaisoa ha molomo oa Zanocin OD ka tekanyo ea 800 mg, tekanyo e phahameng ea lithethefatsi ho plasma e fihlella ka mor'a 7.792 ± 3.0357 h mme ke 5.22 ± 1.24 μg / ml. Boleng ba AUC0-t ke 55.64 ± 11.72 μg • g / ml. In vitro lithethefatsi li tlama liprotheine tsa plasma ke hoo e ka bang 32%.
Khokahano e lekanang ea lithethefatsi ho plasma ea mali e fihlelloa ka mora ts'ebetso e mene ea taolo ea moriana, mme AUC e phahame ho feta 40% ho feta ka mor'a ts'ebeliso e le 'ngoe.
Ho felisoa ha ofloxacin 'meleng ke biphasic. Ka taolo e tsoang khafetsa ea molomo, halofo ea bophelo ba moriana e ka ba lihora tse 4-5 le lihora tse 20-25. Matšoao a ho hlakisoa ka botlalo le bophahamo ba kabo ea thepa a batla a tšoana le ts'ebeliso e le 'ngoe kapa tse ngata.

Ts'ebeliso ea lithethefatsi Zanocin

Zanocin: lethal dose ho latela mofuta oa microorganism le botebo ba ts'oaetso, lilemo, boima ba 'mele le ts'ebetso ea liphio tsa mokuli. Maemong a mangata, phekolo ke matsatsi a 7-7, kalafo e lokela ho tsoelapele ka matsatsi a mang a 2-3 kamora hore matšoao a ts'oaetso a felisoe. Ho ts'oaetso e matla le e rarahaneng, kalafo e kanna ea nka nako e telele. Tekanyetso ea lithethefatsi ke 200-400 mg / letsatsi ho litekanyetso tse peli tse arohaneng. Tekanyetso ea 400 mg (matlapa a mabeli) e ka nooa ka nako e le ngoe, ka ho khetheha hoseng. Ho ka khothaletsoa tekanyetso e le 'ngoe ea 400 mg bakeng sa gonorrhea e bonolo e sa sebetseng. Tekanyetso ea 400 mg e khothaletsoa ke WHO bakeng sa kalafo ea lepera.
Intravenous Drip e tsamaisoa ka tekanyetso ea 200 mg (100 ml) ka tekanyo ea 400 mg / h ka makhetlo a 200-400 mg makhetlo a 2 ka letsatsi.
Haeba ho na le bothata ba ho renal bo sa sebetseng lethal dose e thehiloe ho nahanela botebo ba ho hloleha ha rems le tumello ea creatinine. Motsoako oa pele oa moriana o khothalletsoang ke ts'ebetso ea methapo ea methapo o lokela ho ba 200 mg, ebe monokotso o nkuoa ka lebaka la tumello ea creatinine: ponts'o ea 50-20 ml / min - ka tekanyetso e tloaelehileng ka lihora tse 24, ka tlase ho 20 ml / min - 100 mg (1/2 t cants) mong le e mong lihora tse 24
Ha ho kgothaletswe ho tsoella kalafo le moriana nako e fetang likhoeli tse peli.
Zanocin OD nka nako e le 1 ka letsatsi le lijo. Tekanyetso ea letsatsi le letsatsi e beoa ho latela tafole (bona ka tlase). Litlhahiso tsena li sebetsa ho bakuli ba nang le ts'ebetso e tloaelehileng ea renal (clearinine clearance 50 ml / min). Matlapa a metsitsoe ka botlalo.

Tekanyetso ea letsatsi le letsatsi mg

Ho eketseha ha bronchitis e sa foleng

Mafu a sa rarahanang a tšoaetsanoang ke letlalo le lisele tse poteletseng

Hlooho e sa rarahanang ea urethral le gonorrhea ea cervical

Non-neococcal cervicitis / urethritis e hlahisoang ke C. trachomatis

Tšoaetso e kopaneng ea urethra le cervix e bakoang ke Chlamidia trachomatis le / kapa Neisseria gonorrhoeae

Mafu a bakoang ke ho ruruha ha litho tsa kahare

Cystitis e sa rarahanang e bakoang ke Escherichia coli kapa Klebsiella pneumoniae

Cystitis e sa rarahanang e bakoang ke likokoana-hloko tse ling

1Moemeli oa lefu lena o thehiloe.

Haeba ho na le bothata ba ho renal bo sa sebetseng Tekanyetso e fetoloa ha tumello ea creatinine e le ≤50 ml / min. Kamora tekanyetso e tloaelehileng ea pele, ha u sebelisa Zanocin OD 400 mg, lethal dose le lokisoa ka tsela e latelang:

Tekanyo ea tlhokomelo le khafetsa ea tsamaiso

Bakeng sa mafu a tšoaetsanoang ke letlalo le lisele tse bonolo, pneumonia kapa ho mpefala ha mafu a sa foleng a mali, ho kgothaletswa ho nka Zanocin OD 400 mg ka nako e 'ngoe le e' ngoe ka lihora tse 24. Ho fihlela joale, ha ho na data e tšepahalang mabapi le liphetoho litekanyetsong.

Ho fihla joale, ha ho na data e sa lekanyetsoang mabapi le phetoho ea tekanyetso e khothalletsoang bakeng sa bakuli ba nang le tumello ea creatinine ≤20 ml / min.

Ha o sebelisa Zanocin OD 800 mg ho fihlela joale, ha ho na lintlha tse lekaneng mabapi le liphetoho tsa tekanyetso e khothalletsoang bakeng sa bakuli ba nang le tumello ea creatinine ≤50 ml / min. Haeba feela ho tsebahala ka tlhahiso ea "metabolinine" ka plasma ea mali, ho ka khethoa tumellano ea tlhahiso eaine.

72 (plasma creatinine (mg / dl)

bakeng sa basali: clearinine clearance (ml / min) = 0,85 men creatinine clearance.

Ts'ebetso ea "creatinine" plasma ea mali e hlahlojoa ho lekola boemo ba ts'ebetso ea liphio.
Ts'ebetso ea ho senyeha ha sebete / cirrhosis.
Exlotion ea Ofloxacin e ka fokotsoa ka ho senyeha ho matla ha hepatic (cirrhosis with / bila ascites), ka hona, tekanyetso e kholo ea ofloxacin ha ea lokela ho fetisoa - 400 mg ka letsatsi.
Ho bakuli ba tsofetseng ha ho na tlhoko ea ho fetola tekanyetso, ntle le ha ts'ebetso ea mokokotlo e senyehileng kapa ea hepatic.

Lingoloa tsa setsebi sa bongaka

Setlhare sa antibacterial se pharaletseng - Zanocin - se hlahisoang ke Indian Corporation Ranbaxi Laboratories Ltd. Ntho e sebetsang ealoxacin (ofloxacinum) e senya hampe gritase ea lisele tsa li-microorganisms tsa pathogenic, li sitisa bokhoni ba tsona ba ho ikhula.

Ts'oaetso Lentsoe lena le ile la kena bophelong ba rona ka thata hoo le ileng la emisa ho re tšosa. Batho ba bangata ba nahana hore, "Ke na le tšoaetso, ke noe pilisi, 'me tsohle li felile. Sena se fosahetse. Pathogenic microflora e khona ho senya 'mele ea rona ho tloha kahare ka ntle, esita le ho isa lefung. Sena se ka etsahala haeba mehato e sa nkuoe ka nako. Zanocin e sebelisang antibacterial e sebetsang e entsoe ke sehlopha sa lingaka le bo-rakhopisi e le ho thibela genome ea lisele tsa mofuta oa pathogenic, ho e senya. Kahoo ho imolla mokuli ho lisosa tsa ho hloloa ha hae.Zanocin ea lithethefatsi e tla etsa hore ho khonehe ho lebala ka moahelani ea joalo ea sa phutholohang le ea kotsi joalo ka mafu a tšoaetsanoang a mefuta e fapaneng ea genesis.

Ts'ebetso ea pharmacological ea Zanocin

Sethethefatsi se pharalletseng se loantšang hantle likokoana-hloko tse fapaneng 'meleng oa motho. E na le phello e tobileng ho li-encyme ea DNA ea baktheria, e netefatsang botsitso ba DNA ea baktheria. Ntle le moo, litaelo tsa Zanocin li bontša hore moriana ona o hlahisa phello ea bactericidal. E sebetsa khahlanong le likokoana-hloko tse hlahisang beta-lactamases, hammoho le khahlanong le mycobacteria ea atypical e potlakileng.

Dosing Zanocin le mofuta oa kalafo

Tsamaiso e kenelletseng ea Zanocin e khethoa haeba mokuli a na le ts'oaetso ea mofets'e oa moroto (100 mg), liphio le liphatsa tsa lefutso (100-200 mg), litho tsa ENT le phepelo ea matšoafo, masapo le manonyeletso, tšoaetso ea letlalo, mpeng ea mpa, litho tse bonolo. Ntle le moo, ho latela litlhahlobo, Zanocin e thusa hantle ka tšoaetso ea baktheria le tšoaetso ea septic (200 mg). Setlhare sena se fanoa habeli ka letsatsi. Tekanyetso e ka eketsoa kapa ea fokotseha ho latela boima ba lefu lena, ho sebetsa ha sebete le liphio, le kutloisiso ea likarolo tsa moriana.

Haeba mokuli a e-na le matšoao a hlakileng a ho fokotseha hoa boits'ireletso, molemong oa prophylactic, o fuoa 400-600 mg bakeng sa lihora tse 24.

Ka linako tse ling Zanocin e tsamaisoa ka mokhoa o theohileng ka 200 mg (tharollo e lokela ho ba ncha). Nako ea ts'ebetso ke metsotso e 30.

Litaelo tsa Zanocin li bontša hore moriana ona o boetse o laetsoe ka molomo. Bakeng sa batho ba baholo, tekanyo e phahameng ea letsatsi le letsatsi ke 800 mg. Nako ea kalafo ke libeke tse 1-1,5.

Bakuli ba nang le ts'ebetso e mpe ea menoana ba lokela ho etsa tlhahlobo e eketsehileng mme ba fumane likeletso tsa litsebi. Bakuli ba joalo hangata ba fuoa halofo ea lethal dose ea letsatsi le letsatsi (100 mg). Maemong a mang, 200 mg e tsamaisoa ka lekhetlo la pele, 'me ketsahalo ea kalafo e tsoela pele ka litekanyetso tsa 100 mg.

Maemong a ho hloleha ha sebete, tekanyetso ea letsatsi le letsatsi ke 100 mg (boleng bo phahameng boemong bona ha boa lokela ho feta 400 mg).

Matlapa a 400 a Zanocin OD ha a hlafuna, a hlatsuoa ka metsi a manyane nakong ea lijo kapa pele ho lijo. Tsela e akaretsang ea kalafo e latela boemo ba mokuli, hammoho le hore na lefu le na le nako e kae.

Contraindication

Zanocin ha e fuoe bakuli ba nang le hypersensitivity ho likarolo tsa moriana, ba nang le lefu la sethoathoa, kamora ho lemala hloho, le ts'oaetso ea methapo ea methapo e kholo ea methapo. Ho thibetsoe ka thata ho sebelisa lithethefatsi bakeng sa bana ba ka tlase ho lilemo tse 18, basali baimana, esita le nakong ea ho beleha.

Keletso e eketsehileng ea hlokahala bakeng sa bakuli ba nang le lefu la mokokotlo oa mokokotlo, lesapo la methapo ea methapo le koluoa ea methapo ea methapo.

Tekanyetso le tsamaiso

Ka mokhoa oa tharollo, Zanocin e tsamaisoa ka matla. Litekanyetso le liphoofotsoana tsa infusion li ipapisitse le mofuta oa ts'oaetso, ho teba ha lefu, lilemo tsa mokuli, ts'ebetso ea sebete sa hae le liphio, hammoho le kutloisiso ea likokoana-hloko.

Hangata bakuli ba baholo ba fuoa 200 mg hang kapa habeli ka letsatsi. Ho mafu a matla kapa a rarahaneng, keketseho ea lethal e ka bang 400 mg habeli ka letsatsi e ka khonahala. Sekhahla se phahameng se lumelletsoeng letsatsi ka leng ke 800 mg. Nako ea infusion ke metsotso e 30-60. Pele ho tsamaiso, Zanocin e hlapolotsoe ka tharollo ea 5% ea dextrose. Hang ha boemo ba mokuli bo ntlafala, o fetisetsoa ho tsamaiso ea moriana ka mokhoa oa litafole.

Ka hare, Zanocin e nkuoa 200-500 mg ka letsatsi. Haeba litekanyetso tsa letsatsi le letsatsi li sa feta 400 mg, ho kgothaletswa ho e nka ka nako, ka ho khetheha hoseng. Litekanyetso tse phahameng li arotsoe ka litekanyetso tse peli. Ho hlokahala hore u noe lipilisi pele ho lijo kapa nakong ea lijo.

Le gonorrhea, joalo ka molao, tekanyo e le 'ngoe ea 400 mg ealoxacin e lekane. Ka prostatitis, 300 mg ka letsatsi hangata e fanoa.

Tabeng ea ho senyeha ha mosebetsi oa renal, tekanyo ea Zanocin e ea fokotsoa:

Haeba KK e le 50-20 ml / min - 100-200 mg ka letsatsi,
Haeba CC e ka tlase ho 20 ml / motsotso - 100 mg / letsatsi.

Bakuli ba Hemodialysis ba fuoa 100 mg hang ka letsatsi.

Ka ho hloleha ha sebete le cirrhosis, tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 400 mg.

Nako ea kalafo ea Zanocin e itšetlehile ka kutloisiso ea pathogen ho ofloxacin le setšoantšo sa kliniki ka kakaretso. Ha e le molao, kalafo e tšoarella:

Bakeng sa tšoaetso ea letlalo le tsamaiso ea ho hema - matsatsi a 10,
Ka mafu a tšoaetsanoang a litho tsa pelvic - matsatsi a 10-14,
Ka tšoaetso ea pampiri ea urine - matsatsi a 3-10,
Ka prostatitis - ho fihlela libeke tse 6.

Kamora ho nyamela hoa matšoao ohle a lefu lena, ho sebelisa moriana ho khothaletsoa bonyane matsatsi a 2.

Matlapa a nkang nako e telele Zanocin OD hangata a fuoa:

Ka ts'oaetso ea pampitšana ea urinary le mafu a tšoaetsanoang ka thobalano - 400 mg / letsatsi bakeng sa matsatsi a 3-7, ka ts'oaetso e rarahaneng - matsatsi a 10,
Ka prostatitis - 400 mg ka letsatsi bakeng sa libeke tse 6,
Bakeng sa tšoaetso ea letlalo le lisele tse bonolo, mafu a phepelo ea phefumoloho - 800 mg / ka letsatsi. bakeng sa matsatsi a 10.

Litaelo tse khethehileng

Nako eohle ea kalafo ea hlokahala:

Netefatsa hore metsi a lula hantle 'meleng,
Nako le nako shebella tsoekere ea hau ea mali
Qoba ho pepeseha UV,
Sebelisa tlhokomeliso ha u khanna makoloi 'me u etsa mosebetsi o ka bang kotsi o hlokang tekanyo e phahameng ea karabelo.

Haeba u hloka tšebeliso ea nako e telele ea Zanocin, ho hlokahala hore u laole setšoantšo sa mali a potoloho, a liphio le a sebete.

Ho fokotseha ha khatello ea ofloxacin ho bonoa ka ts'ebeliso e tšoanang ea:

li-antacid tse nang le magnesium, calcium le / kapa aluminium,
Katleho
litokisetso tse nang le li-cation tse fapaneng le tse qabolang,
li-multivitamine, tse kenyeletsang zinki.

Ka lebaka lena, bonyane nako ea lihora tse peli e lokela ho shejoa lipakeng tsa litekanyetso tsa meriana ena.

Li-NSAIDs tse kopantsoeng le oflaxacin li eketsa kotsi ea ho ntlafatsa sephetho se matla sa tsamaiso ea methapo e kholo le nts'etsopele ea sehole.

Matlafatso ea ts'ebetso e kopanetsoeng e bonts'oa ts'ebeliso e kopaneng ea Zanocin e nang le aminoglycosides, lithibela-mafu tsa beta-lactam le metronidazole.

Ofloxacin e liehisa theophylline excretion, e lebisang keketseho ea khatello ea eona le nts'etsopele ea litlamorao tse amanang.

Ashof, Zoflox, Geoflox, Oflox, Ofloxacin, Ofloxabol, Oflomak, Oflotsid, Ofloxin, Tarivid, Taritsin, Tariferid.

Litla-morao tsa lithethefatsi Zanocin

Ka lebaka la lithuto tsa bongaka tse sebelisoang khafetsa ka ho sebelisa mofuta oa "loxacin ", lintlha tse latelang li ne li atisoa hangata: ho nyekeloa pelo (3%), hlooho e bohloko (1%), ho tsekela (1%), lets'ollo (1%), ho hlatsa (1%), lekhopho (1%), ho hlohlona letlalo (1%), ho hlohlona ha litho tsa ka ntle tsa botšehali ho basali (1%), vaginitis (1%), dysgeusia (1%).
Litekong tsa tleleniki, litlamorao tse atileng haholo tse bileng teng ho sa tsotelehe nako ea lithethefatsi e ne e le lefu la ho nyekeloa (10%), hlooho e bohloko (9%), dysomnia (7%), ho hlohlona ha litho tsa kahare tsa botšehali ho basali (6%), ho tsekela (5 %), vaginitis (5%), lets'ollo (4%), ho hlatsa (4%).
Litekong tsa bongaka, litlamorao tse atileng haholo tse bileng teng ho sa tsotelehe nako ea lithethefatsi li bile li bonoa ho 1-3% ea bakuli ba ne ba le bohloko ba ka mpeng le colic, bohloko ba sefuba, ho fokotseha takatso ea lijo, molomo o omileng, dysgeusia, mokhathala, ho bata, mathata a Tšubuhlellano ea ka mpeng, ho tšoha, pharyngitis, pruritus, feberu, ho ruruha, ho hlobaela, ho otsela, ho opeloa ke 'mele, ho senyeha ha botšehali, ho senyeha ha pono, ho ruruha.
Litla-morao tse ileng tsa bonoa lithutong tsa bongaka maemong a ka tlase ho 1%, ho sa tsotelehe nako ea lithethefatsi:
tlolo ea molao ka kakaretso: asthenia, chilliness, malaise, bohloko ba maoto le matsoho, nosebleeds,
ho tsoa ho ts'ebetso ea pelo: ho tšoaroa ke pelo, edema, khatello ea maikutlo, khatello ea maikutlo, maikutlo a ho otla ha pelo, vasodilation,
ho tsoa pampiring ea ka mpeng: dyspepsia
ho tsoa ho tsamaiso ea lefutso: maikutlo a mocheso, ho teneha, bohloko le leqeka sebakeng sa basali sa dysmenorrhea, metrorrhagia,
ho tsoa ho tsamaiso ea musculoskeletal: arthralgia, myalgia,
ho tsoa tsamaisong ea methapo e bohareng: ho tsitsipana, ho tšoenyeha, ho senyeha hoa kelello, ho sithabela maikutlo, litoro tse sa tloaelehang, ho thaba, ho bona lintho tse ling, ho nahana ka mathata, ho akheha, letsoalo, letsoalo,
lehlakoreng la metabolism: lenyora, ho theola boima ba 'mele,
ho tloha tsamaisong ea ho phefumoloha: ho ts'oaroa ha moea, ho khohlela, rhinorrhea,
karabelo le lintho tsohle tse amanang le letlalo: angioedema, hyperhidrosis, urticaria, rash, vasculitis,
ho litho tsa maikutlo: tahlehelo ea litsebe, tinnitus, Photophobia,
ho tsoa ts'ebetsong ea moroto: dysuria, khafetsa ho ntša, ho ntša metsi ka mokokotlong.
Liphetoho maemong a laboratori li ile tsa fumanoa ho ≥1% ea bakuli ba sebelisitsoeng khafetsa ofloxacin. Liphetoho tsena li bakoa ke ho nka moriana le lefu le tlasa lona:
ho tsoa tsamaisong ea mali: anemia, leukopenia, leukocytosis, neutropenia, neutrophilia, stab neutrophilia, lymphocytopenia, eosinophilia, lymphocytosis, thrombocytopenia, thrombocytosis, ESR,
ho tsoa ho hepatobiliary system: maemo a eketsehang a phosphatase ea alkaline, asat, alat,
paramethara ea laboratori: hyperglycemia, hypoglycemia, hypercreatininemia, litekanyo tse eketsehileng tsa urea, glucosuria, proteinuria, alkalinuria, hypostenuria, hematuria, pyuria.
Phihlelo ea ho bapatsa
Litlamorao tse ling tse bileng teng ho sa tsotelehe nako ea ts'ebeliso ea lithethefatsi li ile tsa bonoa ka lebaka la lipatlisiso tsa papatso tsa li-quinolones, ho kenyeletsoa leloloxacin.
Ho tsoa ho tsamaiso ea pelo le pelo: cerebral thrombosis, pulmonary edema, tachycardia, arterial hypotension / shock, failing, ventricular tachycardia e kang pirouette.
Ho tsoa ho endocrine system le metabolism: hyper- kapa hypoglycemia, haholo-holo ho bakuli ba nang le lefu la tsoekere ba sebelisang kalafo ea insulin kapa lithethefatsi tsa molomo.
Ho tsoa pampiring ea ka mpeng: hepatonecrosis, jaundice (cholestatic kapa hepatocellular), hepatitis, intestinal cosmetological, ho se sebetse ha sebete (ho kenyeletsa le linyeoe tse bolaeang), pseudomembranous colitis (matšoao a lefu la pseudomembranous colitis a ka ba teng ka nako le ka mora kalafo ea lithibela-mafu, ho tsoa mali ho tsoa mpeng ea ka mpeng. khetla ea mokokotlo oa molomo.
Ho tsoa ts'ebetsong ea genitourinary: vagidi candidiasis.
Ho tsoa tsamaisong ea mali: phokolo ea mali (ho kenyelletsa hemolytic le aplastic), hemorrhage, pancytopenia, agranulocytosis, leukopenia, reversible inhibition of marrow function, thrombocytopenia, thrombocytopenic purpura, petechiae, subcutaneous hemorrhage / stroke.
Ho tsoa ts'ebetsong ea musculoskeletal: tendonitis, ropo ea tendon, bofokoli, mokokotlo oa masapo le methapo.
Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: litoro, mehopolo ea ho ipolaea kapa liketso, ho ferekanya kelello, maikutlo a kelello, paranoia, phobia, ho ruruha, ho tšoenyeha, ho ba mabifi / ho hlohlona, ho ferekana kelellong, maikutlo a amang maikutlo, ho ruruha ha kelello, ho hloka kelello, ho hokahana ho joalo, ho mpefala ho ka etsahala. myasthenia gravis le mathata a tsoang ho 'mele, dysphasia, kizungu.
Ho tsoa ts'ebetsong ea phefumoloho: dyspnea, bronchospasm, allergic pneumonitis, Wheezing.
Bohloko ba ho kula le letlalo: anaphylactic / anaphylactoid reaction / shock, phenura, lefu la serum, multimorphic erythema / Stevens-Johnson syndrome, erythema nodosum, dermatitis, hyperpigmentation, chefo e hlahisang chefo e ka mpefatsang, ho hlasela kapa ho ts'oarolla mahlo.
Ho tsoa linthong tsa kutlo: diplopia, nystagmus, pono e foufalitsoeng, dysgeusia, monko o senyehileng, ho utloa le ho leka-lekana, tseo, e le molao, li fetang kamora ho emisa moriana.
Ho tsoa ts'ebetsong ea moroto: anuria, polyuria, calculi liphekeng, ho se sebetse hantle ha masapo, liphakeng tsa nephritis, hematuria.
Matšoao a laboratori: ho eketsoa ha nako ea prothrombin, acidosis, hypertriglyceridemia, cholesterol e eketsehileng, potasiamo, li-indices tsa ts'ebetso ea sebete, ho kenyelletsa le gamma-glutamyltranspeptidase, LDH, bilirubin, albinuria ,reliuria.
Litekong tsa kliniki ka tšebeliso ea khafetsa ea li-quinolones, mathata a ophthalmic a ile a fumanoa, ho kenyelletsa lera le ho hlahisa mahlo ka lense. Kamano pakeng tsa ho sebelisa moriana le ponahalo ea litšitiso tsena ha e e-so thehoe.
Ho hlaha ha crystalluria le cylindruria ho tlalehiloe ka ts'ebeliso ea li-quinolones tse ling.

Ts'ebelisano tsa Lithethefatsi Zanocin

Li-antacid, sucralfate, li-cations tsa tšepe, li-multivitamine. Quinolones e etsa metsoako e kopanyang le li-alkaline agents le bajari ba litšepe tsa tšepe. Ts'ebeliso ea li-quinolones hammoho le litokisetso tsa antacid tse nang le calcium, magnesium kapa aluminium, sucralfate, divalent kapa trivalent cations (iron), litokisetso tsa multivitamin tse nang le zinki, didanosine li ka fokotsa haholo ho amoheloa ha li-quinolones, ka ho etsa joalo li fokotsa ts'oarelo ea kemiso ea tsona. Lithethefatsi tse ka holimo li nooa lihora tse 2 pele kapa ka mor'a ho nka ofloxacin.
Caffeine Ha ho na litšebelisano tse fumanoeng.
Li-cyclosporins. Ha ho na litlaleho tsa keketseho ea boemo ba cyclosporine ho plasma ea mali ha e kopantsoe le li-quinolones. Tšebelisano e ka bang teng lipakeng tsa quinolones le cyclosporins ha e so ithutoe.
Cimetidine e bakile tlolo ea molao ea ho felisoa ha li-quinolones tse ling, e leng se entseng hore e eketsehe le halofo ea bophelo ba sethethefatsi le AUC. Tšebelisano e ka bang teng lipakeng tsa ofloxacin le cimetidine ha e e-so ithutoe.
Lithethefatsi tse entsoeng ka motsoako oa li-enzyme tsa cytochrome P450. Litokisetso tse ngata tsa quinolone li thibela tšebetso ea enzymatic ea cytochrome P450. Sena se ka lebisa ho holofatseng ha halofo ea bophelo ba lithethefatsi tse ntlafalitsoeng ke sistimi e tšoanang (cyclosporine, theophylline / methylxanthines, warfarin) ha e kopantsoe le quinolones.
NSAIDs. Ts'ebeliso e kopaneng ea li-NSAIDs le li-quinolones, ho kenyelletsa le ofloxacin, e ka lebisa kotsing e kholo ea phello e matlafatsang tsamaisong ea methapo ea methapo le ho tsitsa.
Propenecid. Ts'ebeliso e kopaneng ea "phenenecid" le "quinolones" e ka ama "renal tubular excretion". Tšusumetso ea probenecid ho onloxacin excretion ha e so ithutoe.
Theophylline. Maemo a theophylline a Plasma a ka eketseha ha a kopantsoe le ofloxacin. Joalo ka li-quinolones tse ling, ofloxacin e ka lelefatsa halofo ea bophelo ba theophylline, e eketsa maemo a theophylline le kotsi ea litlamorao tsa theophylline. Ho hlokahala khafetsa ho tseba palo ea theophylline ho plasma ea mali le ho fetola lethal dose ha e fanoa ka mokhoa o tšoanang le ofloxacin. Litla-morao (ho kenyelletsa ho tsitsipano) li ka hlaha le / ntle le keketseho ea litheko tsa theophylline maling a mali.
Warfarin. Li-quinolones tse ling li ka ntlafatsa litlamorao tsa tsamaiso ea molomo oa warfarin kapa tse tsoang ho eona. Ka hona, ka ts'ebeliso e kopaneng ea li-quinolones le warfarin kapa lihlahisoa tsa eona, nako ea prothrombin le matšoao a mang a ho fetoha ha mali li lula li beiloe leihlo.
Li-antidiabetesic agents (insulin, glyburide / glibenclamide). Ho tlalehiloe phetoho ea tsoekere ea mali, ho kenyelletsa hyper- le hypoglycemia, ha u ntse u sebelisa lithethefatsi tsa quinolone le meriana ea antidiabetic, kahoo glycemia e lokela ho lula e beiloe leihlo le ts'ebeliso e kopaneng ea lithethefatsi tse kaholimo.
Lithethefatsi tse amang renal tubular excretion (furosemide, methotrexate). Ka tsamaiso e ts'oanang ea li-quinolones le lithethefatsi tse amang masapo a methapo ea methapo, ho ka ba le tlolo ea molao oa ho pepesa le keketseho ea boemo ba li-quinolones maling a mali.
Kameho litekong tsa laboratori kapa tsa tlhahlobo ea mali. Li-quinolones tse ling, ho kenyelletsa le ofloxacin, li ka fana ka liphetho tse fosahetseng bakeng sa boikemisetso ba opiate ka har'a moroto ka tsamaiso ea molomo ea li-immunological agents.
Ha ho se na data mabapi le tharollo ea tharollo le tse ling tse tharollo ea infusion kapa litokisetso tsa Zanocin ka mokhoa oa tharollo ea infusion, e tlameha ho sebelisoa ka thoko. Setlhare se lumellana le tharollo ea isotonic sodium chloride, tharollo ea ringer, 5% tsoekere kapa tharollo ea fructose.