Litokisetso tsa Thioctic acid: lenane, mabitso, foromo ea ho lokolla, morero, litaelo tsa tšebeliso, matšoao le li-contraindication

Karolong ena, re nka hore litokisetso tsa thioctic acid ke eng.

Asiti ea Thioctic (α-lipoic) e khona ho tlama li-radicals tsa mahala. Ho theoa hoa 'mele ho etsahala nakong ea ha oxidative decarboxylation ea li-acid tsa α-keto. E nka karolo ts'ebetsong ea oxidative ea decarboxylation ea α-keto acid le pyruvic acid e le enzyme ea mitochondrial multenzyme complexes. Ka phello ea eona ea biochemical, ntho ena e haufi le livithamini tsa B. Litokisetso tsa Thioctic acid li thusa ho ntlafatsa methapo ea methapo ea methapo, khatello ea tsoekere e tlase, ho eketsa maemo a glycogen bokong, ho fokotseha ha insulin, ho ntlafatsa ts'ebetso ea sebete, mme li kenella ka kotlolloho ho metabolism ea lipid le carbohydrate.

Mofumahali

Ha e nkoa ka molomo, asiti ea thioctic e kenella ka potlako. Ka metsotso e 60, e fihla botebong ba 'mele. The bioavailability ea ntho ena ke 30%. Kamora ho kenella kahare ho moriana oa thioctic acid 600 mg ka mora metsotso e 30, ho fihlella boemo bo phahameng ba plasma.

Metabolism e etsahala ka har'a sebete ka ho oxidation ea liketane tse lehlakoreng le ho kopanya. Moriana o na le thepa ea ho fetela pele ka har'a sebete. Bophelo ba halofo ke metsotso e 30-50 (ka liphio).

Fomu ea tokollo

Thioctic acid e hlahisoa ka mefuta e fapaneng ea litekanyetso, haholo-holo ka mokhoa oa litafole le tharollo ea infusion. Litekanyetso li boetse li fapana haholo ho latela sebopeho sa sehlahisoa.

Matšoao a ts'ebeliso ea litokisetso tsa thioctic acid li hlalositsoe ka botlalo ka litaelo. E fuoa li-polyneuropathy tsa lefu la tsoekere le joala.

Contraindication

Lethathamo la li-contraindication ho sesebelisoa sena li kenyelletsa:

• lactose ho hloka mamello kapa ho hloleha,
• galactose le malabsorption ea glucose,
• ho nyeka, ho ima,
• ka tlase ho lilemo tse 18
• maikutlo a phahameng ho likarolo.

Ho kenella ka hare ho moriana ho lokela ho etsoa ka hloko ho batho kamora lilemo tse 75.

Thupelo ea ts'ebeliso

Litokisetso tsa Thioctic acid ka mokhoa oa litafole li nkuoa kaofela, metsotso e 30 pele ho lijo tsa hoseng, ka metsi. Motsoako o khothalelitsoeng ke 600 mg hang ka letsatsi. Lipilisi li qala kamora thuto ea batsoali ka libeke tse 2-5. Tlhahlobo e phahameng ka ho fetisisa ea kalafo ha e fetise libeke tse 12. Phekolo ea nako e telele e ea khonahala joalo ka ha u laetsoe ke ngaka.

Ho tsepamisa mohopolo bakeng sa tharollo ea infusion ho tsamaisoa ka mokhoa o kenang kahare butle-butle. Tharollo e lokela ho lokisoa hang-hang pele ho kenella. Sehlahisoa se lokiselitsoeng se lokela ho sireletsoa ho khanya ea letsatsi, ka sena se ka bolokoa lihora tse 6. Nako ea ts'ebeliso ea foromo ena ea bongaka ke libeke tse 1 - 4, ka mor'a moo u fetole letlapeng.

Ke litokisetso life tsa thioctic acid tse ntle ho khahlisang ho ba bangata.

Litlamorao

Maemo a latelang a bophelo a hlaha e le karabelo e mpe ha o sebelisa moriana ona:

• ho hlatsa, ho nyekeloa, lets'ollo, bohloko ba ka mpeng, ho otla ha pelo,
• karabelo (mziba oa letlalo, ho hlohlona), ho ts'oaroa ha anaphylactic,
• tlolo ea tatso
• hypoglycemia (mofufutso o feteletseng, cephalalgia, kizungu, pono e fifalitsoeng),
• thrombocytopathy, phenura, hemorrhages ea petechial mucous membrane le letlalo, hypocoagulation,
• autoimmune insulin syndrome (bathong ba nang le lefu la tsoekere),
• ho chesa haholo, makhopho,
• ts'ebetso e eketsehileng ea li-enzyme tsa tšiloanya lijo,
• bohloko bo ka pelong, ka ho kenella ka potlako ha moemeli oa pharmacological - ho eketseha ha sekhahla sa pelo,
• thrombophlebitis
• diplopia, pono e fifalitsoeng,
• boemo bo sa thabiseng sebakeng sa ente, hyperemia, ho ruruha.

Ka tsamaiso e potlakileng ea lithethefatsi, khatello ea intracranial (e fetang ka boeona) e ka eketseha, ho thatafalloa ho hema le ho fokola.

Lithethefatsi tse nang le Acid ena

Meriana e latelang ke litokisetso tse atileng haholo tsa thioctic acid:

• Berlition.
• "Lipothioxone."
• Oktolipen.
• "Thioctacid."
• "Neyrolipon".
• Thiogamma.
• "Lipolotiki".
• Tielepta.
• Espa Lipon.

Lithethefatsi "Berlition"

Sesebelisoa sa mantlha sa moemeli enoa oa meriana ke alpha-lipoic acid, e leng ntho e kang vithamine e bapala karolo ea coenzyme ts'ebetsong ea oxarative decarboxylation ea alpha-keto acid. E na le litla-morao tsa antioxidant, hypoglycemic, neurotrophic. Fokotsa boemo ba sucrose maling le ho eketsa bongata ba glycogen bokong, e fokotsa ho hanyetsa ha insulin. Ntle le moo, karolo ena e laola metabolism ea mafura le lik'habohaedreite, e ntlafatsa metabolism ea cholesterol.

Ho bakuli ba nang le lefu la tsoekere la mofuta o mong le o mong, thioctic acid e fetola khatello ea "pyruvic acid" maling, e thibela ho pepesetsoa ha glucose liprotheine tsa vascular le ho theoa hoa likarolo tsa ho qetela tsa glycosation. Ntle le moo, asiti e khothalletsa tlhahiso ea glutathione, e ntlafatsa ts'ebetso ea sebete ho bakuli ba nang le hepatic pathologies le ts'ebetso ea tsamaiso ea methapo ho bakuli ba nang le lefu la tsoekere la methapo ea pelo. E nka karolo ho metabolism ea mafura, thioctic acid e khona ho susumetsa tlhahiso ea li-phospholipids, ka lebaka leo litho tsa 'mele tsa lisele li khutlisitsoeng, metabolism ea matla le ho romella litšusumetso tsa methapo li tsitsitseng.

The drug "Lipothioxone"

Tokisetso ena ea thioctic acid ke mofuta oa li-antioxidant oa mofuta oa tlhaho o kopanyang li-radicals tsa mahala. Thioctic acid e bapala karolo ea bohlokoa ho mitochondrial metabolism liseleng, hape e sebetsa e le coenzyme ts'ebetsong ea phetoho ea lintho tse nang le litlamorao tsa antitoxic. Li sireletsa lisele ho li-radicals tse etsahalang nakong ea phapanyetsano e lipakeng kapa ho bola ha lintho tse tsoang kantle ho naha, hammoho le tšusumetsong ea tšepe e boima. Ntle le moo, ntho ea mantlha ke synergistic mabapi le insulin, e amanang le keketseho ea ts'ebeliso ea tsoekere. Ho diabetes, thioctic acid e khothalletsa phetoho maemong a madi a pyruvic acid.

Moriana "Oktolipen"

Ena ke moriana o mong o thehiloeng ho thioctic acid - coenzyme ea lihlopha tse ngata tsa methenzondme ea multenzyme, e nkang karolo ts'ebetsong ea oxarative decarboxylation ea acid ea α-keto le acid ea pyruvic. Ke antioxidant ea endo native: e felisang li-radicals tsa mahala, e khutlisetsa maemo a glutathione kahare ho lisele, e eketsa ts'ebetso ea superoxide dismutase, axonal conductivity le trophic neurons. E bapala karolo ea bohlokoa ho metabolism ea matla, e sebetsa hantle lipotropic, 'me e ntlafatsa ts'ebetso ea sebete. E na le phello ea detoxifying haeba ho na le chefo ea tšepe e boima le tahi e meng.

Litlhahiso tse khethehileng mabapi le tšebeliso ea meriana

Nakong ea kalafo ka lithethefatsi tse thehiloeng ho thioctic acid, motho o lokela ho hana ho noa joala. Bakuli ba nang le lefu la tsoekere ba hloka ho shebeloa khafetsa maemo a tsoekere ea mali, haholo-holo nakong ea ts'ebeliso ea moriana o itseng. Bakeng sa ho qoba nts'etsopele ea hypoglycemia, ho ka hlokahala litlatsetso tsa litekanyetso tsa insulin kapa meriana ea molomo ea hypoglycemic. Haeba matšoao a hypoglycemia a hlaha, tšebeliso ea thioctic acid e lokela ho emisoa hanghang. Ho boetse ho molemo maemong a ho ntlafatsoa ha methapo ea methapo ea kutlo, mohlala, ho hlohlona ha letlalo le malaise.

Tšebeliso ea lithethefatsi nakong ea kemolo, ho lactation le ho bana

Ho latela litlatsetso bakeng sa ts'ebeliso ea lithethefatsi tse nang le thioctic acid, lithethefatsi tsena li loants'oa nakong ea bokhachane le pelehi. Ho khethoa ha lichelete tsena bongoaneng ho boetse hoa hanyetsoa.

Ho sebelisana le lithethefatsi

Hoa hlokahala ho hlokomela nako ea ho qeta bonyane lihora tse peli ha u sebelisa thioctic acid e nang le lithethefatsi tse nang le tšepe, hammoho le lihlahisoa tsa lebese. Tšebelisano e kholo ea lithethefatsi ea asiti ena e bonoa ka lintho tse latelang:

• cisplatin: ts'ebetso ea eona ea fokotseha
• glucocorticosteroids: ho matlafatsa litlamorao tsa bona tse khahlanong le ho ruruha,
• ethanol le metabolites tsa eona: ho fokotsa ho pepesetsoa ha thioctic acid,
• lithethefatsi tsa hypoglycemic tsa molomo le insulin: litlamorao tsa tsona lia ntlafatsoa.

Lithethefatsi tsena ka mokhoa oa li-complication bakeng sa ho hlophisoa ha tharollo ea infusion ha li lumellane le tharollo ea dextrose, fructose, tharollo ea Ringer, hammoho le tharollo e arabang lihlopha tsa SH- le discride.

Theko ea litlhare tsena

Litsenyehelo tsa meriana le litaba tsa asiti ea thioctic acid li fapana haholo. Theko e hakantsoeng ea matlapa a 30 likhomphutha. ka tekanyetso ea 300 mg e lekane - li-ruble tse 290, li-pcs tse 30. ka tekanyetso ea li-ruble tse 600 - 650-690 li-ruble.

Litokisetso tse ntle tsa thioctic acid li tla thusa ngaka ho khetha.

Litlhahlobo mabapi le lithethefatsi

Litlhahlobo mabapi le lithethefatsi li ntle haholo. Litsebi li leboha haholo thepa ea tsona ea kalafo e le neuroprotective le antioxidant mme ba khothaletsa ts'ebeliso ea batho ba nang le lefu la tsoekere le mefuta e mengata ea polyneuropathies. Bakuli ba bangata, hangata basali, ba sebelisa lithethefatsi tse joalo ho theola boima, empa maikutlo a arotsoe ka katleho ea lithethefatsi tse joalo bakeng sa ho theola boima ba 'mele. Litsenyehelo tse phahameng tsa meriana ena le tsona lia hlokomeloa.

Ho ea ka bareki, meriana e fetisetsoa hantle haholo, litla-morao ha li hlahe hangata, 'me hangata lipakeng tsa tsona ho laoloa hangata, hangata ho leng bobebe, matšoao a iponahatsa a le mong kamora ho emisa moriana.

Re shebile lethathamo la litokisetso tsa acid ea thioctic.