Gliclada® (30 mg) Gliclazide > Phekolo le thibelo

Matlapa a lokolotsoeng a 30 mg

Letlapa le leng le na le

ntho e sebetsang - gliclazide 30 mg

Baeti: hypromellose (4000 **), hypromellose (100 **)

calcium carbonate, lactose monohydrate, colloidal silicon diode, magnesium stearate

** Boleng ba bophahamo ba lebitso bo hlalosang tharollo ea metsi e nang le 2% (m / v) ea hypromellose

Matlapa a oval, ho tloha ho o mosoeu ho isa ho o mosoeu, biconvex hanyane

Sehlopha sa Pharmacotherapeutic

Mokhoa oa ho phekola lefu la tsoekere. Lithethefatsi tse theolelang tsoekere bakeng sa tsamaiso ea molomo. Mehloli ea sulfonylureas. Gliclazide

Khoutu ea ATX A10VB09

Ketso ea pharmacological

Mofumahali

Tlhahiso le kabo

Kamora ho kenya moriana kahare, gliclazide e kenelletse ka botlalo ho tsoa pampiring ea mala. Khetla ea gliclazide ho plasma e eketseha hanyane ka hanyane nakong ea lihora tsa pele tsa 6 kamora tsamaiso mme e fihla sehlabeng se phehellang ho tloha ka la 6 ho isa ho la 12. Phapang ea motho ka mong e tlaase haholo. Ho ja ha ho ame boemo ba ho monya. Boholo ba thepa bo ajoa ka lilithara tse 30. Plasma protein e tlamang ke hoo e ka bang 95%. Tekanyetso e le 'ngoe ea letsatsi le leng le le leng ea lithethefatsi Gliclada® e netefatsa hore ho boloka motsoako o sebetsang oa glyclazide ho plasma ea mali ka lihora tse fetang tse 24.

Gliclazide e tšelisoa haholo-holo ka har'a sebete. Li-metabolites tse hlahisoang ha li na mesebetsi ea meriana. Kamano pakeng tsa lethal dose e nkiloeng ho fihlela ho 120 mg le ts'oarelo ea lithethefatsi ho plasma ke ts'ehetso ea nako ka nako.

Nako ea halofo ea bophelo (T1 / 2) ea gliclazide ke lihora tse 12-20. E hloekisoa haholo ke liphio ka mokhoa oa metabolites, e ka tlase ho 1% e pepesitsoeng ka har'a moroto o sa fetohe.

Pharmacokinetics maemong a khethehileng a kliniki

Ho batho ba tsofetseng, ha ho liphetoho tse bonts'itsoeng maemong a bongaka a pharmacokinetic.

Mofumahali

Gliclada® ke sethethefatsi se tsoang ka molomo se tsoang ho sehlopha sa sulfonylurea se tsoang molokong oa bobeli, se fapaneng le lithethefatsi tse tšoanang ka ho ba le selikalikoe se nang le heterocyclic sa N se nang le endocyclic bond.

Glyclada® e theola tsoekere ea mali ka ho susumetsa secretion ea "insulin" ke lihlekehleke tsa Langerhans tse nang le lisele tsa R. Kamora kalafo ea lilemo tse peli, keketseho ea boemo ba insulin ea secprandial le secretion ea C-peptides ea sala. Ho mofuta oa 2 lefu la tsoekere, lithethefatsi li khutlisa tlhoko ea pele ea "insulin secretion" ho arabela tšebeliso ea tsoekere le ho matlafatsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e bonoa ho arabela ts'usumetso ka lebaka la ho ja lijo le tsamaiso ea tsoekere.

Ntle le ho ama metabolism ea carbohydrate, Glyclada® e na le phello ho microcirculation. Setlhare se fokotsa kotsi ea "thrombosis" e nyane ea mali, e ama mekhoa e mmedi e ka amehang ho nts'etsopele ea mathata a lefu la tsoekere: ho thibela likarolo tsa methapo le ho khomarela le ho fokotseha ha lintho tse ngata tse amanang le mokokotlo oa mokokotlo (beta-thromboglobulin, thromboxane B2) vascular endothelial shughuli le tšebetso e eketsehang ea activator ea plasminogen.

Tekanyetso le tsamaiso

Setlhare sena se reretsoe bakuli ba baholo feela.

Ho khothalletsoa ho nka letlapa (s) ntle le ho hlafuna nakong ea lijo tsa hoseng. Haeba u fetoa ka tekanyetso e latelang ka letsatsi le hlahlamang, u ke ke ua eketsa tekanyo.

Tekanyetso ea letsatsi le letsatsi ea Glyclad® e tsoa ho 30 ho isa ho 120 mg (matlapa a 1 ho isa ho a 4). Tekanyo ea lithethefatsi e khethoa ho latela karabelo ea motho ka mong ea metabolic.

Motsoako oa ho qala o khothalelitsoeng ke 30 mg ka letsatsi. Ka taolo e sebetsang ea tsoekere, lethal dose lena le ka sebelisoa e le pheko ea tlhokomelo.

Ka taolo e sa lekanang ea litekanyetso tsa tsoekere, tekanyetso ea letsatsi le letsatsi ea lithethefatsi e ka eketseha butle-butle ea fihla ho 60, 90 kapa 120 mg. Nako e pakeng tsa keketseho e ngoe le e ngoe ea karo e lokela ho ba bonyane khoeli e le 'ngoe, ntle le ho bakuli bao boemo ba tsoekere bo sa fokotsehang kamora libeke tse peli tsa taolo. Maemong a joalo, tekanyetso e ka eketsoa libeke tse peli kamora ho qala kalafo. Sekhahla se khothalelitsoeng ke 120 mg ka letsatsi.

Ho fetoha ho tloha ho 80 mg Glyclazide Letlapa ho Glyclad Modised Release Tablets®

Tabeng ea taolo e sebetsang ea khatello ea tsoekere maling a mokuli ka matlapa a 80 mg glycoslide, a ka nkeloa sebaka ke Glyclada® ka tekanyo ea letlapa le le leng la glycoslide 80 mg = 1 letlapa la Glyclada®.

Ho tloha ho sethethefatsi se seng sa hypoglycemic ho ea Glyclad®

Kamora phetoho, litekanyetso le halofo ea bophelo ba moriana o fetileng li lokela ho tsotelloa. Nako ea phetoho hangata ha e hlokehe. Ho amoheloa ha lithethefatsi Glyclada® ho lokela ho qala ka 30 mg, e lateloe ke phetoho ho latela karabelo ea metabolic.

Ha o tloha ho lithethefatsi tse ling tsa sehlopha sa sulfonylurea tse nang le halofo ea bophelo, e le ho qoba tšusumetso e matla ea lithethefatsi tsena tse peli, nako e se nang lithethefatsi ea matsatsi a 'maloa e ka hlokahala.

Maemong a joalo, phetoho ea matlapeng a Glyclad ® e lokela ho qala ka lethal dose ea 30 mg e khothalletsoang, e lateloe ke keketseho ea tekanyetso ea litheko ho latela ts'ebetso ea metabolic.

Sebelisa hammoho le lithethefatsi tse ling tsa antidiabetes

Gliclada® e ka laetsoa hammoho le biguanides, alpha-glucosidase inhibitors kapa insulin. Tsamaiso e ts'oanang ea insulin e lokela ho qala ka tlasa taolo e tiileng ea ngaka.

Bakuli ba tsofetseng (ba fetang lilemo tse 65)

Moriana o fanoe ka tekanyetso e lekanang le ea bakuli ba ka tlase ho lilemo tse 65.

Bakeng sa bakuli ba nang le tsitsipano e bobebe kapa e itekanetseng ea ts'ebetso ea moriana, moriana o fanoa ka tekanyetso e tloaelehileng.

Bakuli ba nang le kotsi e eketsehileng ea hypoglycemia: khaello ea phepo e nepahetseng, mafu a nang le mathata a endocrine a matla kapa a futsanehileng haholo (hypopituitarism, hypothyroidism, ho haella ha adrenocorticotropic hormone, kamora kalafo ea nako e telele le / kapa ea tekanyetso e phahameng ea pelo, kalafo e khothalletsoa ho qala ka bonyane tekanyetso ea letsatsi le letsatsi ea 30 mg.

Litlamorao

hypoglycemia (haeba ho e-ja khafetsa kapa ho ja lijo tse sa tsitsang): hlooho ea hlooho, tlala e matla, ho nyekeloa, ho hlatsa, ho khathatseha boroko, ho ferekana, pherekano, ho hloka matla, ho se tsotelle haholo, ho fokotsa ts'ebetso, khatello ea maikutlo, ho hloka thuso, mathata a pono le puo , aphasia, paresis, ho thothomela, ho fokotseha ha maikutlo, ho tsekela, bradycardia, tsitsipano, ho felloa ke boitšoaro, ho otsela, ho hema ka thata, ho felloa ke kelello, ho ferekana kelellong, ho lebisang ho komeng le lefung. Matšoao a adrenergic a khoneha: mofufutso o thata, ho tšoenyeha, tachycardia, khatello e phahameng ea mali, bohloko pelong, arrhythmia

bohloko ba ka mpeng, ho nyekeloa, ho hlatsa, lets'ollo, ho sokela (ho ka fokotsoa ka ho sebelisa moriana nakong ea lijo tsa hoseng)

Keketseho e khutlisetsang maemong a hepatic enzymes (ALT, AST, alkaline phosphatase), hepatitis (ka seoelo), hyponatremia

lekhopho la letlalo, ho hlohlona, urticaria, angioedema, erythema, maculopapular rashes, maikutlo a lipolao (joalo ka Stevens-Johnson syndrome, chefo e ka pele ea chefo)

anemia, leukopenia, thrombocytopenia, granulocytopenia, pancytopenia (e fetoha hape kamora ho tlosoa hoa lithethefatsi)

ho senyeha ho sa bonahaleng ha nakoana, haholo qalong ea kalafo, ka lebaka la liphetoho tsoekere ea mali

Contraindication

hypersensitivity ho gliclazide kapa e 'ngoe ea likarolo tse thusang tsa lithethefatsi, hammoho le lithethefatsi tse ling tsa sehlopha sa sulfonylurea kapa sulfonamides

mofuta oa 1 lefu la tsoekere

lefu la tsoekere la ketoacidosis, precomatosis le lefu la tsoekere

ho ruruha haholo kapa ho hloleha ha sebete

ho ima le ho nyekeloa

Ho sebelisana le lithethefatsi

Ts'ebeliso e kopaneng ea gliclazide le miconazole e hokahane mabapi le kotsi ea hypoglycemia, ho fihlela ho hypoglycemic coma.

Glyclazide ha e khothalletsoe ho sebelisoa ka nako e ts'oanang le phenylbutazone le joala ka lebaka la kotsi e eketsehileng ea hypoglycemia. Nakong ea phekolo le moriana, ho bohlokoa ho hana ho noa joala le ho sebelisa meriana e nang le joala.

Mabapi le kotsi ea ho ba le hypoglycemia, tlhokomeliso e lokela ho sebelisoa ha ho ntse ho fanoa ka lithethefatsi tsa gliclazide le antidiabetic tsa lihlopha tse ling (insulin, acarbose, biguanides), beta-blockers, fluconazole, angiotensin-converting enzyme inhibitors (Captopril, enalapril), le H2 receptor antist. (IMAO), li-sulfonamides le lithethefatsi tse seng khahlanong le ts'oaetso tsa li-antiidal.

Tšebeliso e ts'oanang ea gliclazide le danazol ha e khothalletsoe ka lebaka la kotsi ea ho eketseha ha tsoekere ea mali. Haeba ho hlokahala, ho khethoa ha motsoako o joalo ho lokela ho hlokomela ka hloko boemo ba tsoekere maling le moroto, 'me maemong a mang, u lokise tekanyetso ea gliclazide nakong ea kalafo le danazol le kamora eona.

Ka lebaka la kotsi ea ho ba le hyperglycemia, tlhokomeliso e lokela ho sebelisoa ha ho kopantsoe gliclazide le chlorpromazine (ka tekanyetso ea> 100 mg ka letsatsi, e qetellang e baka ho fokola hoa secretion ea insulin). Bakeng sa nako ea kalafo ea chlorpromazine, ho ka hlokahala phetoho ea litheko tsa gliclazide.

Glucocorticosteroids (bakeng sa ts'ebeliso ea kemiso le ea lehae: intraarticular, sub- kapa subcutaneous, rectal) le tetracosactides, ha e nkuoa hammoho le glycoslazide, e eketsa litekanyetso tsa tsoekere ea mali mme, ka lebaka la phokotso ea mamello ea carbohydrate, e ka baka ketosis. Nakong ea kalafo le ka mor'a kalafo ea glucocorticoid, ho ka hlokahala phetoho ea litekanyetso tsa gliclazide.

Ho lokela ho ba hlokolosi ts'ebelisong ea gliclazide e kopaneng le ritodrine, salbutamol le tertbutaline (kahare) ka lebaka la kotsi ea ho ba le hyperglycemia. Haeba ho hlokahala, fetohela kalafo ea insulin.

Ka tšebeliso e kopaneng ea gliclazide e nang le li-anticoagulants (warfarin, jj), keketseho ea phello ea anticoagulant e ka bonoa.

Litaelo tse khethehileng

Moriana o lokela ho laeloa feela ka ho ja lijo tse tloaelehileng ke mokuli (ho kenyeletsa le lijo tsa hoseng).

Kotsi ea hypoglycemia e eketseha ka lijo tse nang le khalori e fokolang, ka mor'a ho ikoetlisa ka nako e telele kapa ho ikoetlisa ka ho feteletseng, ho noa joala kapa ho sebelisa lithethefatsi tse 'maloa tsa hypoglycemic.

Ka lebaka la kotsi e eketsehang ea hypoglycemia, ho khothalletsoa hore o noe lik'habohaedreine khafetsa (haeba lijo li nkuoa kapele, haeba lijo tse sa lekanang, kapa lijo li na le lik'habohaedreite tse tlase).

Hypoglycemia e ka hlaha kamora ts'ebeliso ea lintho tse tsoang ho sulfonylurea. Maemong a mang ho ka ba thata le ho qeta nako e telele. Ho kena sepetlele ho ka hlokahala, 'me tsoekere e ka hlokahala le matsatsi a' maloa.

Ho fokotsa kotsi ea ho ba le liketsahalo tsa hypoglycemic, ho hlokahala taeo e hlokolosi ea mokuli.

Lintho tse eketsang kotsi ea hypoglycemia:

Overdose

Ho hloleha ha letsoalo le sebete: Melemo ea pharmacokinetic le ea pharmacodynamic ea gliclazide e ka fetoha ho bakuli ba nang le hepatic kapa renal e thata ea ho hlaphoheloa. Likarolo tsa Hypoglycemic tse etsahalang ho bakuli ba joalo li ka ba telele ka nako e telele, ka hona ho lokelang ho tsamaisoa leihlo le nepahetseng.

Mokuli o lokela ho tsebisoa ka bohlokoa ba ho ja, tlhoko ea ho ikoetlisa khafetsa le ho lekola maemo a tsoekere ea mali kamehla. Bakuli le ba malapa a bona ba hloka ho hlalosa kotsi ea hypoglycemia, ho bua ka matšoao a eona, mekhoa ea kalafo le lintho tse rerang pele ho nts'etsopele ea khatello ena.

Taolo ea tsoekere e maling

Katleho ea ho laola ho kenella ha tsoekere maling maling a mokuli ea fumanang kalafo ea lefu la tsoekere e ka angoa ke lintlha tse latelang: feberu, ho lemala ha 'mele, ts'oaetso, kapa ho kenella. Maemong a mang, ho ka hlokahala ho fana ka insulin.

Ts'ebetso ea hypoglycemic ea lithethefatsi leha e le life tsa antidiabetic tsa molomo, ho kenyelletsa le gliclazide, ho bakuli ba bangata e fokotseha ho feta nako ka lebaka la tsoelo-pele ea lefu la tsoekere kapa ho fokotseha ha karabelo ea lithethefatsi (bobeli ho hloka phello ea kalafo). Qeto mabapi le ho ba sieo ha sekhahla sa phello ea kalafo e ka etsoa feela kamora phetoho e lekaneng ea tekanyetso le haeba mokuli a latela lijo.

Ha ho hlahlojoa taolo ea tsoekere ea mali, ho khothaletsoa hore tekanyo ea hemoglobin ea glycated (kapa glucose ho plasma ea mali a venous) e lekanngoe.

Ho fana ka litlhare tsa sulfonylurea ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase ho ka lebisa ho hemolytic anemia. Ho lokela hore ho sebelisoe tlhokomeliso ha ho laeloa bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase mme ba nahane ka kalafo e 'ngoe ka lithethefatsi tsa sehlopha se seng.

Tlhahisoleseling e khethehileng ho Bafani

Gliclada® e na le lactose. Bakuli ba nang le mafu a fumanehang ka seoelo a galactose ho hloka mamello, ho haella ha lappase kapa glucose-galactose malabsorption ha baa lokela ho nka moriana ona.

Lintlha tsa phello ea lithethefatsi ho bokhoni ba ho khanna makoloi kapa mekhoa e ka bang kotsi

Ho hlokahala hore u be hlokolosi ha u khanna makoloi kapa u sebelisa mekhoa e meng, haholo-holo qalong ea kalafo.

Bongata

Matšoao e leka-lekaneng ho isa ho hypoglycemia e matla.

Phekolo: matšoao a hypoglycemia e leka-lekaneng ntle le ho lahleheloa ke ho tseba kapa matšoao a ho senyeha ha methapo ea kutlo, tlosa tšebeliso ea lik'habohaedreite, tokiso ea litekanyetso le / kapa phetoho ea lijo. Tlhokomelo e matla ea bongaka e lokela ho tsoelapele ho fihlela ngaka e netefatsa hore mokuli o tsitsitse ebile o kotsing.

Likarolo tse matla tsa hypoglycemia, e tsamaeang le ho akheha, ho akheha kapa mafu a mang a methapo ea kutlo, e hloka tlhokomelo ea tšohanyetso le ho kena sepetlele hanghang. Haeba hypoglycemic coma e etsahala kapa e belaelloa, glucagon le 50 ml ea tharollo ea glucose e kenelletseng (20-30% kahare) e lokela ho kenngoa hang-hang, 'me joale u tsoele pele ho kenella ka tharollo ea tsoekere ea 10% ka tekanyo e netefatsang hore khatello ea tsoekere ea mali e feta 1 g / l . Mokuli o lokela ho ba tlas'a tlhokomelo e thata ea bongaka. Hemodialysis ha e sebetse.

Sehlopha sa mahlale

Li-ejenti tsa hypoglycemic tsa molomo, li-sulfonamides, li-urea tse tsoang. Khoutu ATX A10V B09.

Glyclazide ke sethethefatsi se tsoang ka molomo (hypoglycemic drug), se fumanoang sulfonylurea, se fapaneng le lithethefatsi tse ling ka ho ba le selikalikoe sa heterocyclic se nang le naetrojene 'me se na le litlamo tsa endocyclic.

Glyclazide e fokotsa maemo a tsoekere ea plasma ka lebaka la ho hlohlelletsoa ha seculin ka insulin ke lisele tsa β tsa lihlekehleke tsa "pancreatic" tsa Langerhans. Keketseho ea boemo ba insulin ea postprandial le secretion ea C-peptide e phehella esita le ka mor'a lilemo tse peli tsa ts'ebeliso ea lithethefatsi. Gliclazide e boetse e na le thepa ea hemovascular.

Kameho ho secretion ea insulin.

Ho bakuli ba nang le lefu la tsoekere la mofuta oa II, gliclazide e khutlisa tlhaselo ea pele ea insulin ha e arabela ho ja tsoekere le ho eketsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e etsahala ho ipapisa le moroalo oa lijo kapa tsoekere ea glucose.

Glyclazide e fokotsa microthrombosis ka lebaka la mekhoa e 'meli e ka amehang ho ntlafatseng mathata a lefu la tsoekere:

ka tsela e itseng e thibela ho kopana ha liplatelete le ho khomarela, ho fokotsa palo ea li-activation tsa liplatelese (β-thromboglobulin, thromboxane B 2)
e ama ts'ebetso ea fibrinolytic ea vascular endothelium (e eketsa mosebetsi oa tRA).

Phello ea mantlha e ne e le liketsahalo tse ka sehloohong tsa macrovascular (lefu la pelo, lefu le sa bolaeang la myocardial infarction, lefu le sa bolaeang) le li-microvascular (linyeoe tse ncha kapa nephropathy e mpe le ho feta).

Bakuli ba 11,140 ba kenyelelitsoe litekong tsa bongaka. Libekeng tse 6 tsa kenyelletso, bakuli ba ile ba tsoela pele ho nka kalafo ea bona e tloaelehileng ea ho theola tsoekere. Ebe ho latela molao-motheo o hlophisitsoeng, bakuli ba ile ba fuoa regimen e tloaelehileng ea taolo ea glycemic (n = 5569) kapa regimen ka tsamaiso ea glycoslide, matlapa a lokolotsoeng, a ipapisitseng le leano la taolo e matla ea glycemia (n = 5571). Leano la taolo e matla ea glycemic le ne le thehiloe ho khethoeng ha gliclazide, matlapa a nang le tokollo e fetotsoeng, ho tloha qalong ea kalafo, kapa ho khethoa ha gliclazide, matlapa a nang le tokollo e fetotsoeng, ho fapana le kalafo e tloaelehileng (kalafo eo mokuli a e fumaneng ka nako ea ho kenyelletsa) le kenyelletso ea lithethefatsi tse ling tse fokotsang tsoekere, haeba ho hlokahala, joalo ka metformin, acarbose, thiazolidinediones kapa insulin. Bakuli ba ne ba beiloe leihlo ka hloko 'me ba latela lijo ka tieo.

Ho shebella ho nkile lilemo tse 4,8. Sephetho sa kalafo ka gliclazide, matlapa a lokolotsoeng a fetotsoeng, eo e neng e le motheo oa leano la taolo e matla ea glycemic (boemo bo pakeng ba HbAlc - 6.5%) ha bo bapisoa le taolo e tloaelehileng ea glycemia (kakaretso e fihletsoeng ea HbAlc - 7,3%) Kotsi ea 10% ea likotsi tse kholo tsa macro- le microvascular ((HR) 0.90, 95% Cl 0.82, 0.98 p = 0.013, 18.1% ea bakuli ba tsoang sehlopheng sa taolo e matla ha ba bapisoa le 20% ea bakuli ba tsoang sehlopheng seo taolo e tloaelehileng). Melemo ea leano la taolo e matla ea glycemic le ho ts'oaroa ha gliclazide, matlapa a lokisitsoeng a lokolloang motheong oa kalafo a ne a hlahisoa ke:

ho fokotseha ho hoholo ha menyetla e meholo ea liketsahalo tse kholo tse potlakileng ke 14% (HR 0.86, 95% Cl 0.77, 0.97, p = 0.014, 9.4% bapisoa le 10.9%),
ho fokotseha ho hoholo hoa menyetla e lekanang ea linyeoe tse ncha kapa ho eketseha ha nephropathy ka 21% (HR 0.79, 95% Cl 0.66 - 0.93, p = 0.006, 4.1% bapisoa le 5.2%),
phokotso e kholo ea 8% menyetla e lekanyelitsoeng ea Microalbuminuria e etsahetseng ka lekhetlo la pele (HR 0.92, 95% Cl 0.85 - 0.99, p = 0.030, 34.9% bapisoa le 37,9%),
ho fokotseha ho hoholo hoa menyetla e lekanyelitsoeng ea liketsahalo tsa renal ka 11% (HR 0.89, 95% Cl 0.83, 0.96, p = 0.001, 26.5% khahlano.

Qetellong ea thuto, 65% le 81.1% ea bakuli sehlopheng se matla sa taolo (bapisoa le 28.8% le 50.2% ea sehlopha se laolehileng) ba fihletse HbAlc ≤ 6.5% le ≤ 7%, ka ho latellana. 90% ea bakuli ba sehlopheng se matla sa taolo ba ile ba nka gliclazide, matlapa a lokisitsoeng a lokolotsoeng (karolelano ea litekanyetso tsa letsatsi le letsatsi e ne e le 103 mg), 70% ea bona e ne e nka lethathamo la letsatsi le letsatsi la 120 mg. Ka sehlopha sa taolo e matla ea glycemic e thehiloeng ho gliclazide, matlapa a lokolotsoeng a lokolloang, boima ba 'mele oa mokuli bo ile ba lula bo tsitsitse.

Melemo ea leano la taolo e matla ea glycemic e thehiloeng gliclazide, matlapa a lokolotsoeng a lokolloang, a ne a sa itšetleha ka ho theola khatello ea mali.

Tekanyo ea gliclazide ho plasma ea mali e nyoloha nakong ea 6:00 ea pele, e fihla sehlabeng seo e leng lihora tse tšeletseng ho isa ho tse leshome le metso e mmedi ka mor'a taolo ea lithethefatsi.

Ho feto-fetoha ha maemo ha motho ka mong ha ho na letho.

Glyclazide e kenelletse ka botlalo. Ho ja ha ho ame sekhahla le boholo ba ho monya.

Plasma protein e tlamang ke hoo e ka bang 95%. Kamano lipakeng tsa lethal dose e nkuoeng ka bongata ho fihlela ho 120 mg le sebaka se katlaneng ea nako ea mahloriso se mela. Boholo ba thepa bo ajoa ka lilithara tse 30.

Gliclazide e tšelisoa ka har'a sebete 'me e tšeloa ka har'a moroto, ka tlase ho 1% ea ntho e sebetsang e pepesetsoa ka har'a moroto o sa fetoheng. Ha ho na metabolites e sebetsang ho plasma.

Bophelo ba halofo ea gliclazide ke lihora tse 12-20.

Bakeng sa bakuli ba tsofetseng, ha ho na liphetoho tse kholo tsa kliniki ho litlhare tsa meriana.

Tekanyetso e le 'ngoe ea lithethefatsi Glyclada, matlapa a nang le tlhahiso e fetotsoeng, e boloka motsoako o sebetsang oa glycazide ho plasma ka lihora tse 24.

Mofuta oa II oa lefu la tsoekere:

fokotseha le taolo ea tsoekere ea mali ho etsahala hore tsoekere e se ke ea fetoloa ka lijo, ho ikoetlisa kapa ho theola boima ba 'mele
thibelo ea mathata a mofuta oa lefu la tsoekere la mofuta oa II: ho fokotsa kotsi ea mathata a maholo ka ho fetisisa le a potlakileng, ho kenyelletsa linyeoe tse ncha kapa nephropathy e ntseng e mpefala ho bakuli ba nang le lefu la tsoekere la mofuta oa II.

Moetsi

Krka, dd Novo Mesto, Slovenia

Šmarješka 6, 8501 Novo Mesto, Slovenia

Aterese ea mokhatlo e amohelang likopo ho tsoa ho bareki ka boleng ba lihlahisoa (thepa) Rephaboliking ea Kazakhstan

Krka Kazakhstan LLP, Kazakhstan, 050059, Almaty, Al-Farabi Ave. 19, moaho oa 1 b,

Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano

Ha o sebelisa lithethefatsi, tsamaiso e tšoanang e ka bakang hypo- kapa hyperglycemia, Sidid e hlokomelisa mokuli ka tlhoko ea ho lekola maemo a tsoekere ea mali nakong ea kalafo. Phetoho ea litekanyetso tsa moriana oa hypoglycemic e ka hlokahala nakong ea kalafo le meriana ena le ka mor'a eona.

Mekhoa ea meriana e ka eketsang kotsi ea hypoglycemia

Miconazole (bakeng sa tšebeliso ea systemic, gel e rarahaneng) e ntlafatsa sephetho sa hypoglycemic ka nts'etsopele ea matšoao a hypoglycemia kapa esita le komisi.

Ha e khothalletsoe motsoako

Phenylbutazone (bakeng sa ts'ebeliso ea ts'ebetso) e ntlafatsa phello ea hypoglycemic ea sulfonylurea (e nkela khokahano ea eona le liprotheine tsa plasma le / kapa e fokotsa tlhahiso ea eona). Ho bohlokoa ho sebelisa sethethefatsi se seng se loantšang ho ruruha 'me se hohela tlhokomelo ea mokuli ho tlhoko le bohlokoa ba boitšoaro. Haeba ho hlokahala, litekanyetso tsa Glyclad li laoloa nakong le ka mor'a kalafo ea lithethefatsi tse khahlanong le ho ruruha.

Joala bo ntlafatsa karabelo ea hypoglycemic (ka ho thibela mats'oafo a mokokotlo), e ka lebisang ho qaleheng ha komello ea hypoglycemic. Qoba tšebeliso ea lithethefatsi tse nang le joala le tšebeliso ea joala.

Mekhaako e hlokang ho ba hlokolosi

Ho matlafatsa phello ea hypoglycemic ea lithethefatsi mme, maemong a mang, hypoglycemia e ka hlaha ka lebaka la ts'ebeliso e ts'oanang ea lithethefatsi tse ling tsa antidiabetic ka meriana e joalo (insulin, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase 4 inhibitors, glucose-1-phosphate receptor agonists, Li-inhibitors tsa ACE (Captopril, enalapril), bahanyetsi ba H 2 receptor, li-inhibitors tsa MAO, sulfonamides, clarithromycin, le lithethefatsi tse seng khahlanong le ts'oaetso tsa steroidal.

Meriana e ka bakang keketseho ea tsoekere ea mali

Ha e khothalletsoe motsoako

Danazole: Matla a diabetogenic a Danazol.

Haeba ts'ebeliso ea ntho ena e sebetsang e ke ke ea qojoa, mokuli o lokela ho lemosoa ka tlhoko le bohlokoa ba ho itlhahloba ha tsoekere maling le morong. Ho kanna ha hlokahala hore u fetole tekanyetso ea li-antidiabetesic agents nakong le ka mor'a kalafo le danazol.

Mekhaako e hlokang ho ba hlokolosi

Chlorpromazine (antipsychotic): tšebeliso ea litekanyetso tse phahameng tsa chlorpromazine (> 100 mg ka letsatsi) e eketsa boemo ba tsoekere maling (ka lebaka la ho fokotseha ha secretion ea insulin).

Mokuli o lokela ho lemosoa ka tlhoko le bohlokoa ba ho lekola maemo a tsoekere ea mali. Ho kanna ha hlokahala hore u fetole tekanyetso ea ntho e sebetsang ea antidiabetesic nakong le ka mor'a kalafo ea li-antipsychotic.

Glucocorticoids (bakeng sa ts'ebeliso ea tšebetso le ea li-topical: litokisetso tsa methapo, letlalo le litekanyo) le tetracosactrin e eketsa tsoekere ea mali ka nts'etsopele e ka khonehang ea ketosis (ka lebaka la mamello e fokotsitsoeng ea lik'habohaedreite ka glucocorticoids).

Mokuli o lokela ho lemosoa ka tlhoko le bohlokoa ba ho lekola maemo a tsoekere ea mali, haholo qalong ea kalafo. Ho kanna ha hlokahala ho fetola tekanyetso ea li-antidiabetesic agents nakong ea kalafo ea glucocorticoid le ka mor'a eona.

Ritodrin, salbutamol, terbutaline (c) e eketsa boemo ba tsoekere maling maling ka lebaka la bakuli ba beta-2.

E lokela ho hlokomelisoa ka tlhoko ea ho laola maemo a tsoekere ea mali. Haeba ho hlokahala, mokuli o lokela ho fetisetsoa ho insulin.

Metsoako eo u lokelang ho e hlokomela

Phekolo ka li-anticoagulants (joalo ka warfarin, jj) litokisetso tsa sulfonylurea li ka ntlafatsa phello ea anticoagulant ka kalafo e kopanetsoeng. Ho ka 'na ha hlokahala hore u ntlafatse tokiso ea litheko tsa anticoagulant.

Likarolo tsa ts'ebeliso

Kalafo e ngoletsoe bakuli ba khonang ho latela lijo tse tloaelehileng le tse tloaelehileng (ho kenyeletsa le lijo tsa hoseng). Ho bohlokoa hore o jang lik'habohaedreite kamehla ka lebaka la menyetla e eketsehang ea hypoglycemia, e etsahalang ha lijo li nkuoa ka nako e telele, ka tekanyo e sa lekaneng, kapa haeba lijo li le tlase ho lik'habohaedreite. Kotsi ea hypoglycemia e eketseha ka phepo e tlase ea khalori, ho ikoetlisa ka nako e telele le ka matla, ka joala kapa ka motsoako oa li-hypoglycemic agents.

Hypoglycemia e ka hlaha ka lebaka la tšebeliso e le 'ngoe ea litokisetso tsa sulfonylurea le (bona "liphetoho tse fapaneng") maemong a mang li ka ba matla le ho feta halelele. Ka linako tse ling ho hlokahala sepetlele le tšebeliso ea tsoekere ka matsatsi a 'maloa.

Tlhahlobo e felletseng ea bakuli, tšebeliso ea litekanyetso tse itseng tsa moriana le ho khomarela litekanyetso le litekanyetso tsa ts'ebeliso li hlokahala ho fokotsa kotsi ea hypoglycemia.

Lintho tse eketsang kotsi ea hypoglycemia:

ho hana kapa (haholo-holo ho bakuli ba tsofetseng) ho se khone ho sebelisana ha mokuli,
Lijo tse tlase-khalori kapa lijo tse sa tloaelehang, lijo tse bobebe, linako tsa ho itima lijo kapa liphetoho tsa lijo,
tlolo ea tekano lipakeng tsa boikoetliso ba 'mele le boemo ba ho ja nama ea lik'habohaedreite,
ho hloleha ha rems
ho hloleha ho matla ha sebete
overdose ea Glyclad,
maloetse a mang a tsamaiso ea endocrine: lefu la qoqotho, hypopituitarism le ho haella ha adrenal,
tšebeliso ea nako e tšoanang ea meriana e meng e itseng (bona karolo "Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano").

Ho hloleha ha letsoalo le sebete

Pharmacokinetics le / kapa pharmacodynamics ea gliclazide e ka fapana ho bakuli ba nang le hepatic kapa e matla ea renal. Likarolo tsa hypoglycemia tse etsahalang ho bakuli ba joalo li ka tšoarelleha 'me tsa hloka mehato e itseng.

Tlhahisoleseling ea mokuli

Mokuli le litho tsa lelapa la hae ba lokela ho hlokomelisoa ka kotsi ea hypoglycemia, ho hlalosa matšoao a eona (bona karolo "Karabelo e mpe"), kalafo, hammoho le lintlha tse eketsang kotsi ea kholo ea eona.

Bakuli ba lokela ho tseba bohlokoa ba lijo, ho ikoetlisa khafetsa le litekanyo tsa tsoekere ea mali khafetsa.

Tlolo ea molao oa tsoekere ea mali

Lintho tse latelang li ka ama taolo ea litekanyetso tsa tsoekere ea mali ho bakuli ba noang meriana e thibelang lefu la tsoekere: feberu, ho sithabela maikutlo, ts'oaetso, kapa ho buuoa. Maemong a mang, insulin e ka hlokahala.

Bokhabane ba hypoglycemic ba meriana efe kapa efe ea antidiabetes, ho kenyelletsa le gliclazide, bo fokotseha ha nako ho bakuli ba bangata: sena se ka hlaha ka lebaka la ho phahama ha lefu la tsoekere kapa ho fokotseha ha karabelo kalafong. Ketsahalo ena e tsejoa e le ho hloleha ho bobeli, e fapaneng le ea mantlha ha ntho e sebetsang e sa sebetse kalafong ka moriana oa mola oa pele. Ho lokela ho etsoa phetoho e nepahetseng ea lijo le lijo pele u fetisetsa mokuli ho sehlopha sa bobeli se sa sebetseng.

Ho khothalletsoa ho tseba hore na hemoglobin ea boemo ba "glycosylated hemoglobin" (kapa boemo ba tsoekere e potlakileng ho plasma ea mali). Ho ithekela tsoekere ea mali le hona e ka ba ho loketseng.

Phekolo ea bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase e nang le litokisetso tsa sulfonylurea e ka lebisa ho anemia ea hemolytic. Kaha gliclazide ke ea sehlopha sa lik'hemik'hale tsa litokisetso tsa sulfonylurea, bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase le bona ba lokela ho ba hlokolosi; kalafo e 'ngoe ka lithethefatsi tse se nang sulfonylurea le eona e lokela ho nahaneloa.

Litlhokomeliso Tse Khethehileng Mabapi le Lihlooho Tse Ling

Gliclada e na le lactose. Bakuli ba nang le ts'oaetso ea lefutso ea lactose e sa tloaelehang, ba nang le galactosemia kapa glucose-galactose malabsorption syndrome ha baa lokela ho nka sethethefatsi sena.

Sebelisa nakong ea bokhachane kapa leboteng.

Ha ho na boiphihlelo ka tšebeliso ea gliclazide nakong ea kemolo, leha ho na le bopaki bo teng mabapi le tšebeliso ea sulfonylureas tse ling.

Taolo ea lefu la tsoekere e lokela ho fihlella pele ho bokhachane ho fokotsa kotsi ea ts'ebetso ea tsoalo e amanang le khaello ea taolo ea lefu la tsoekere.

Ts'ebeliso ea lithethefatsi tsa antidiabetic tsa molomo ha e khothalletsoe, insulin ke lithethefatsi tse ka sehloohong bakeng sa kalafo ea lefu la tsoekere nakong ea kemolo. Ho khothalletsoa ho fetisetsa mokuli ho insulin haeba ho ka etsahala hore ho be le kemaro e reriloeng kapa ha e etsahala.

Lethathamo la ho kenella ha gliclazide kapa metabolite ea lona ka lebese la matsoele ha le fumanehe. Ka lebaka la kotsi ea ho ba le hypoglycemia ho ngoana, tšebeliso ea lithethefatsi e patiloe ho basali ba anyang matsoele.

Bokhoni ba ho susumetsa sekhahla sa karabelo ha u khanna kapa u sebetsa ka mekhoa e meng.

Gliclada ha e na tšusumetso e tsebahalang mabapi le bokhoni ba ho khanna koloi kapa ho sebetsa ka mochini. Leha ho le joalo, bakuli ba lokela ho ba hlokolosi mabapi le ho qala ha matšoao a hypoglycemia mme ba be hlokolosi ha o khanna kapa o sebelisa mochine, haholo-holo qalong ea kalafo.

Lintho tse fapaneng tse tla etsahala

Ho ipapisitsoe le boiphihlelo ka li-derivatives tsa gliclazide le sulfonylurea, litlamorao tse latelang li tlalehiloe.

Phepo e sa khaotseng, haholo-holo ho itima lijo nakong ea phekolo e nang le sulfonylureas, ho kenyeletsoa Glyclad, e ka lebisa nts'etsopele ea hypoglycemia. Matšoao a ka bang teng a hypoglycemia: hlooho e opang, tlala e matla, ho nyekeloa, ho hlatsa, ho ferekana, ho tšoenyeha ka boroko, ho tšoenyeha, ho teneha, ho tsepamisa mohopolo, ho lahleheloa ke tsebe le ho fokotsa lintho tse etsahalang, ho tepella maikutlo, ho se bone hantle le ho bua, aphasia, ho thothomela, paresis, ho senyeha ha methapo ea kutlo. , ho tsekela, ho felloa ke boitšoaro, ho ferekana kelellong, ho tsitsipana, ho hema ka thata, bradycardia, ho otsela, ho felloa ke letsoalo esita le ho nts'etsapele komello e nang le sephetho se bolaeang.

Ntle le moo, ho ka ba le lipontšo tsa pherekano ea tsamaiso ea adrenergic: ho ruruha ho feteletseng, ho tiea ha letlalo, ho tšoenyeha, tachycardia, khatello ea methapo ea pelo, palpitations ea pelo, angina pectoris le arrhasmia.

Ka mehla matšoao a nyamela kamora ho nka carbohydrate (tsoekere). Leha ho le joalo, linoko tse monate tsa maiketsetso ha li na phello. Phihlelo ka litokisetso tse ling tsa sulfonylurea e bontša hore hypoglycemia e ka hlaha khafetsa, le haeba mehato e sebetsang e ile ea nkuoa hang-hang.

Haeba likarolo tsa hypoglycemia li matla ebile li nka nako e telele, le haeba li laoloa ka nakoana ke tšebeliso ea tsoekere, ho kena sepetlele hang-hang le tlhokomelo ea bongaka ea tšohanyetso li hlokahala.

Maemo a mangata a hypoglycemia a bonoa ho bakuli ba nang le phekolo ea insulin.

Litla-morao tse ling

Ho tsoa pampitšana ea ka mpeng: bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, dyspepsia, lets'ollo le ho sokela. Matšoao ana a ka felisoa kapa a fokotsoa ka ho nka gliclazide nakong ea lijo tsa hoseng.

Tse latelang ke litlamorao tse sa rateheng tse sa tloaelehang.

Karolong ea letlalo le lisele tse poteletseng: ho ruruha, ho hlohlona, urticaria, angioedema, redness, maculopapular rash, reactionfulous (e.g. Stevens-Johnson syndrome le chefo e matla ea cyermalosis).

Ho tsoa lits'ebetsong tsa potoloho ea mali le li-lymphatic: liphetoho maemong a hematological, ho kenyelletsa phokolo ea mali, leukopenia, thrombocytopenia, granulocytopenia. Lintho tsena lia tloaeleha ebile hangata lia nyamela kamora hore moriana o felisitsoe.

Karolong ea sekhahla sa sebete le biliary: keketseho ea li-enzyme tsa sebete (AST, ALAT, alkaline phosphatase), hepatitis (linyeoe tse ikhethileng). Tabeng ea jaundice ea cholestatic, tšebeliso ea lithethefatsi e lokela ho emisoa.

Ho tloha lehlakoreng la setho sa pono: Ho senyeha ha nakoana hoa pono, ka lebaka la liphetoho maemong a tsoekere maling, ho senyeha hoa nakoana hoa pono ho etsahala, haholoholo qalong ea kalafo.

Liphello tsa tlhaho ea lihlahisoa tsa sulfonylurea:

Joalo ka litokisetso tse ling tsa sulfonylurea, ho bile le maemo a erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, allergic vasculitis, hyponatremia, li-enzymes tse phahameng tsa sebete le ts'ebetso e mpe ea sebete (mohlala, ka cholestasis le jaundice) le hepatitis e nyamela kamora ho tlohela kapa linyeoe ka bomong li lebisa ho ho senyeha ha sebete ha sebete.

Melemo ea pharmacological

Gliclazide e fokotsa maemo a tsoekere ea plasma ka lebaka la ho hlohlelletsoa ha seculin ka insulin ke li-cells-cell tsa li-isanc tsa li-pancreatic tsa Langerhans. Keketseho ea boemo ba insulin ea postprandial le secretion ea C-peptide e phehella esita le ka mor'a lilemo tse peli tsa ts'ebeliso ea lithethefatsi.

Gliclazide e boetse e na le thepa ea hemovascular.

Kameho ho secretion ea insulin.

Gliclazide e fokotsa microthrombosis ka mekhoa e 'meli e ka amehang ho hlahiseng mathata a lefu la tsoekere:

ka tsela e itseng e thibela ho kopana ha liplatelete le ho khomarela, ho fokotsa palo ea li-activation tsa liplatelese (β-thromboglobulin, thromboxane B 2)
e ama ts'ebetso ea fibrinolytic ea vascular endothelium (e eketsa mosebetsi oa tRA).

Thibelo ea mathata a lefu la tsoekere la mofuta oa II.

ADVANCE ke teko ea machabeng e nang le tlhaiso-leseling e nang le moralo oa bi-factorial, o reretsoeng ho supa melemo ea leano le matla la taolo ea glycemic (HbAlc ≤ 6.5%) e ipapisitse le litafole tse lokollotsoeng tsa glycoslide (Gliclazide MR) ha li bapisoa le taolo e tloaelehileng ea glycemic le melemo ea ho theola khatello ea mali. khatello ea ho sebelisa motsoako o tsitsitseng oa perindopril / indapamide ha e bapisoa le placebo mokokotlong oa kalafo e tloaelehileng ea morao-rao (bapisoa ka bofofu habeli) ho latela phello ea sehlooho liketsahalo tse Micro- and microvascular ho bakuli ba nang le lefu la tsoekere la mofuta oa II.

Phuputso e kenyelelitse bakuli ba 11 140 ba nang le lefu la tsoekere la II lefu la tsoekere (bolela: lilemo tse 66, BMI (boima ba 'mele) 28 kg / m 2, nako ea lefu la tsoekere lilemo tse 8, boemo ba HbAlc ba 7.5% le SBP / DBP (systolic khatello ea mali / khatello ea mali ea diastolic) 145/8 mmHg). Har'a bakuli bana, 83% e ne e na le khatello ea mali, ho bakuli ba 325 le ho 10%, mafu a macro- le micro-vascular a tlalehiloe nalane ea lefu lena, ka ho latellana, mme ho 27%, microalbuminuria (MAU) e fumanoe. Boholo ba bakuli ba ile ba phekoloa pele ho lefu la tsoekere la mofuta oa II, 90% - ka ho sebelisa moriana o (47% - monotherapy, 46% - kalafo habeli le 7% - makhetlo a mararo) le 1% e nang le insulin ha 9% e ne e le lijong feela. Qalong, sulfonylurea (72%) le metformin (61%) li ne li behiloe haholo-holo. Phekolo ea Concomitant e ne e kenyelletsa 75% ea lithethefatsi tse fokotsang khatello ea mali (BP), lithethefatsi tse fokotsang lipid (35%, haholo-holo li-statins - 28%), aspirin le li-antiplatelet agents tse ling (47%). Nakong ea libeke tse 6 tsa tsamaiso ea motsoako oa perindopril / indapamide le kalafo e fokotsang tsoekere e tloaelehileng, bakuli ba nang le molao-motheo ba khethiloeng ba fuoa regimen e tloaelehileng ea glycemic (n = 5569), kapa MR glycazide regimen e ipapisitse le leano la taolo ea glycemia e matla (n = 5571). Leano la taolo e matla ea glycemic le ne le thehiloe ho fana ka taelo ea Gliclazide MR ho tloha qalong ea kalafo kapa ho fana ka taelo ea Gliclazide MR sebakeng sa kalafo e tloaelehileng (kalafo eo mokuli a e fumaneng ka nako ea kenyelletso) ka keketseho ea tekanyetso ho fihlela moo ho hlokahalang, hape, ha ho hlokahala, tlatsetso ea lithethefatsi tse ling tsa hypoglycemic, joalo ka: metformin, acarbose, thiazolidinediones kapa insulin. Bakuli ba ne ba beiloe leihlo ka hloko 'me ba latela lijo ka tieo.

Ho shebella ho nkile lilemo tse 4,8. Liphetho tsa kalafo ea Gliclazide MR, eo e neng e le motheo oa leano la taolo e matla ea glycemic (karolelano e lekantsoeng ea HbAlc ke 6.5%) ha e bapisoa le taolo e tloaelehileng ea "glycemia" (kakaretso e fihletsoeng ke HbAlc ke 7.3%), phokotso e kholo ea 10% e amanang kotsi ea mathata a maholo a macro- le microvascular ((HR) 0.90, 95% Cl 0.82, 0.98 p = 0.013, 18.1% ea bakuli ba tsoang sehlopheng sa taolo e matla ha ba bapisoa le 20% ea bakuli ba tsoang sehlopheng se laoloang se tloaelehileng). Melemo ea leano la taolo e matla ea glycemic le ho khethoa ha MR gliclazide e thehiloeng kalafong e bile ka lebaka la:

ho fokotseha ho hoholo hoa menyetla e lekanang ea liketsahalo tse kholo tsa microvascular ka 14% (HR 0.86, 95% Cl 0.77, 0.97, p = 0.014, 9.4% vs 10.9%),
ho fokotseha ho hoholo hoa menyetla e lekanang ea linyeoe tse ncha kapa ho eketseha ha nephropathy ka 21% (HR 0.79, 95% Cl 0.66 - 0.93, p = 0.006, 4.1% vs 5.2%),
ho fokotseha ho hoholo hoa menyetla e lekanyelitsoeng ea microalbuminuria, e ileng ea hlaha ka lekhetlo la pele, ka 8% (HR 0.92, 95% Cl 0.85 - 0.99, p = 0.030, 34.9% vs 37.9%),
ho fokotseha ho hoholo hoa menyetla e lekanyelitsoeng ea liketsahalo tsa renal ka 11% (HR 0.89, 95% Cl 0.83, 0.96, p = 0.001, 26.5% vs 29.4%).

Qetellong ea thuto, 65% le 81.1% ea bakuli ba sehlopheng se matla sa taolo (vs. 288% le 50.2% ea sehlopha se laolehileng) ba fihletse sepheo sa HbAlc sa ≤ 6.5% le ≤ 7%, ka ho latellana.

90% ea bakuli ba sehlopheng se matla sa taolo ba ile ba nka Gliclazide MR (karolelano ea litekanyetso tsa letsatsi le letsatsi e ne e le 103 mg), 70% ea bona e nkile lethal dose le phahameng la letsatsi le letsatsi la 120 mg. Sehlopheng se matla sa taolo ea glycemic e thehiloeng ho Gliclazide MR, boima ba 'mele ba mokuli bo ile ba lula bo tsitsitse.

Melemo ea leano la Glycoslazide MR le etsoang ka matla ho laola glycemic e ne e sa itšetleha ka ho theola khatello ea mali.

Tekanyo ea gliclazide ho plasma ea mali e nyoloha nakong ea 6:00 ea pele, e fihla sehlabeng se phehellang lihora tse 6 ho isa ho tse tšeletseng ka mor'a ts'ebetso ea moriana. Gliclazide e kenelletse ka ho felletseng ka seterateng sa ka mpeng. Ho ja ha ho ame sekhahla le boholo ba ho monya.

Kamano e pakeng tsa lethal dose ho fihlela ho 120 mg le sebaka se katlasa nako ea mahlakore a mahloriso li ka mela. Ho kopanya liprotheine tsa plasma ke 95%.

Gliclazide e batla e na le metabolism e felletseng kahare 'me e tšeloa ka har'a moroto. Ka tlase ho 1% ea gliclazide e pepesitsoe e sa fetoloe ka har'a moroto. Ha ho na metabolites e sebetsang ho plasma.

Bophelo ba halofo ea gliclazide e tsoang 'meleng ke lihora tse 12-20. Boholo ba thepa bo ajoa ka lilithara tse 30.

Ha u sebelisa tekanyetso e le 'ngoe ea moriana, khatello ea gliclazide e plasma ea mali e bolokoa lihora tse 24.

Ho bakuli ba tsofetseng, paramo ea pharmacokinetic ha e fetoloe haholo.

Phapang pakeng tsa motho ka mong e tlaase.

Mofuta oa II oa lefu la tsoekere:

fokotseha le taolo ea tsoekere ea mali ha ho khonahala ho fokotsa maemo a tsoekere feela ka lijo, boikoetliso kapa ho theola boima ba 'mele
thibelo ea mathata a mofuta oa lefu la tsoekere la mofuta oa II: ho fokotsa kotsi ea mathata a maholo ka ho fetisisa le a potlakileng, ho kenyelletsa linyeoe tse ncha kapa nephropathy e ntseng e mpefala ho bakuli ba nang le lefu la tsoekere la mofuta oa II.

AnaChildren

Sebelisa nakong ea bokhachane kapa ka ho lactation

Ts'ebeliso ea lithethefatsi tsa antidiabetic tsa molomo ha e khothalletsoe, insulin ke lithethefatsi tse ka sehloohong bakeng sa kalafo ea lefu la tsoekere nakong ea kemolo. Ho khothalletsoa hore phetisetso ea mokuli ho insulin ketsahalong ea kemolo e reriloeng kapa ha e etsahala.