Setlhare se fumaneha ka mokhoa oa tharollo ea infusion. Ke mokelikeli o hlakileng o hlakileng o bosoeu bo bosehla.

Ho tsepamisa mohopolo ho boetse hoa rekisoa, e sebelisetsoang ho lokisa tharollo. Ke tharollo e hlakileng kapa e botala bo bosehla.

Litafole tsa Ciprinol 250 mg ke biconvex, li na le sebopeho se chitja, 'mala o mosoeu, mekhabiso e tlotsitsoeng. Li koaheloa ke membrane ea filimi, ka lehlakoreng le leng la tafole ho na le notch.

Litafole tsa Ciprinol 500 mg ke biconvex, li na le sebopeho sa oval, mmala o mosoeu. Letlapa le koahetsoe ka membrane ea filimi, ka lehlakoreng le leng ho na le notch.

Litafole tsa Ciprinol 750 mg li na le oval sebopeho, li na le koae e tšoeu ea filimi, 'me ho na le lintlha ka mahlakoreng a mabeli a letlapa.

Ketso ea pharmacological

Ciprinol (ciprofloxacin) e na le litlamorao tse khahlanong le 'mele. Ena ke moloko oa bobeli monofluorinated fluoroquinolone. Tlas'a tšusumetso ea eona, topoisomerase II, enzyme e khethollang pheko le biosynthesis ea baktheria deoxyribonucleic acid, e thibetsoe. O nka karolo ea hae molemong oa karohano ea lisele tsa libaktheria le khabong ea liprotheine.

Ciprinol e na le litlamorao tsa bactericidal, e sebetsa hantle haholo khahlanong le libaktheria tse seng ntle le gram. Ka hona, moriana o sebelisoa kalafo ea maloetse a bakoang ke libaktheria tsena.

Hape, libaktheria tse 'maloa tse nang le gram tse ntle li na le bothata ho Ciprinol: Staphylococcus spp., Streptococcus spp. E ama likokoana-hloko tse 'maloa tsa intracellular.

Ho sebetsa hantle ha lithethefatsi ho bonoa kalafong ea mafu a tšoaetsanoang a halefisitsoeng ke Pseudomonas aeruginosa. Ciprinol ha e sebetse khahlano le chlamydia, anaerobes, mycoplasmas. Li-Uyo, livaerase, protozoa haholo li bontša ho hanela ketso ea moriana.

Pharmacodynamics le pharmacokinetics

Ciprinol ka tsela ea litafole e kenngoa ka potlako, e kenella ka har'a tšilo ea lijo. Ho monya ha eona ha ho amehe ke tšebeliso ea lijo, bioavailability ea eona ha ea fokotseha. Bioavailability ke 50-85%. Karolelano ea lintho tse sebetsang maling a mokuli e bonoa lihora tse ka bang 1-1,5 kamora ho nka matlapa. Kamora ho monya, sesebelisoa se sebetsang se ajoa ka har'a lisele tsa genitourinary le phefumoloho, ho mokelikeli o kopaneng, mesifa, letlalo, linama tse mafura, mathe, sputum, fluid fluid. E kenella ka har'a lisele (macrophages, neutrophils), e khethang ts'ebetso ea eona kalafong ea mafu a tšoaetsanoang moo likokoana-hloko li fumanehang sebakeng sa tsona.

Ka lebaka la biotransformation e hlahang ka har'a sebete, li-metabolites tse sa sebetseng li hlaha. Lithethefatsi li tlosoa 'meleng ho tsoa lipelong, le ka ts'ebetso ea mekhoa e meng e fetelletseng (e nang le makhopho, e nang le bile). Bophelo ba halofo ea lithethefatsi ho tsoa 'meleng ke ho tloha ho lihora tse 5 ho isa ho tse 9. Ka hona, bakeng sa kalafo e sebetsang, ho lekane ho nka moriana oo habeli ka letsatsi.

Kamora ho kenngoa ha tharollo e kenelletseng ea Ciprinol, khatello e phahameng e fihlella kamora hora ea 1. Ka kenyelletso ea karolelano ea ho kenella kahare ho litho tsa 'mele, moo ho nang le khatello e phahameng ea ntho e sebetsang ha e bapisoa le plasma ea mali, ho boletsoe. Ciprofloxacin e kenella hantle ka har'a placenta.

Ho batho ba nang le ts'ebetso e tloaelehileng ea renal, bophelo ba halofo ea lithethefatsi bo tsoa ho lihora tse 3 ho isa ho tse 5. Bakeng sa bakuli ba nang le bothata ba ho phekoloa ke pheko, halofo ea bophelo e eketseha ho fihlela lihora tse 12.

Kamora ho kenella, sethethefatsi se qheleloa ka liphio. Hoo e ka bang 50-70% ea lithethefatsi ha li sa fetoloa, tse ling li 10% li hlahisoa ka mokhoa oa metabolites, palo e setseng - ka tšilo ea lijo. Ka lebese la matsoele, karolo e nyane ea ntho e sebetsang e ntšoa.

Matšoao Ciprinol

Ciprinol e laetsoe ha ho hlokahala ho phekola tšoaetso e hlahisitsoeng ke likokoana-hloko tse nang le sensitivity e phahameng ho ciprofloxacin, eo ho eona motho a bang le lefu le itseng. Ka hona, matšoao a ts'ebeliso ea lithethefatsi ke a latelang:

tšoaetso ea pampitsana ea phefumoloho:bronchitispneumonia, cystic fibrosis, bronchiectasis, jj.
mafu a tšoaetsanoang a ENT: mecha ea litaba ea otitis, mastoiditis, sinusitis,
pampitsana ea urine le mafu a liphio: cystitis, urethritispyelonephritis,
mafu a tšoaetsanoang a litho tsa botšehali, hammoho le litho tse ling tsa pelvic: prostatitis, epididymitis, endometritis, chlamydia, salpingitis, jj.
mafu a tšoaetsanoang a litho tsa ka mpeng: cholecystitischolangitis, abscess ea methapo, lets'ollo, ho hola ka lebaka la ts'oaetso, jj.
tšoaetso ea letlalo le lisele tse bonolo: ulc, burns le maqeba a hlahang tšoaetsong, phlegmon, abscesses,
ts'oaetso ea musculoskeletal: ramatiki ea lefutso, osteomyelitis,
nts'etsopele ea sepsis, ts'oaetso ho batho ba nang le bothata ba ho holofala ho itsireletsa,
mehato ea thibelo ho thibela kholo ea ts'oaetso nakong ea ts'ebetso ea bongaka le ea masapo,
kalafo le thibelo ea anthrax ea pulmonary.

Contraindication

Ciprinol ha ea lokela ho laeloa mafu le maemo a latelang:

tekanyo e phahameng ea kutlo ea ciprofloxacin, lithethefatsi tse ling tsa sehlopha sa fluoroquinolones kapa likarolo tse ling tsa lithethefatsi.
nako ea boimana le nako ea ho fepa,
lilemo ho isa ho lilemo tse 18 (ntle le kalafo ea mathata a bakoang ke Pseudomonas aeruginosa ho bana ba lilemo tse 5 ho isa ho 17 ba nang le lefu la pulmonic cystic fibrosis, le eona e sebelisetsoa kalafo le thibelo ea koatsi ho bana),
se ke ua sebelisa lithethefatsi ka nako e tšoanang le Tizanidine.

Ciprinol e laetsoe ka hloko ho bakuli ba boima atherosulinosis lijana tsa bokong, mali a sa tsoaleng bokong le bokong ba batho lefu la sethoathoa, bokuli ba kelello, ho hloleha ha liphio kapa sebete. Boemo ba batho ba tsofetseng ba ntseng ba phekoloa ka sethethefatsi, hammoho le ba nang le khaello ea glucose-6-phosphate dehydrogenase, bo lokela ho beoa leihlo ka ho hlaka.

Litlamorao

Sistimi ea lijo: tlhagiso ya dyspeptic phenomena, anorexia, hepatonecrosis, hepatitis, cholestatic jaundice, pseudomembranous colitis.
Tsamaiso ea methapo e bohareng:hlooho e bohloko, migraine, boemo bo phahameng ba ho tepella le ho tšoenyeha, ho akheha, ho nyekeloa, ho thothomela, ho ruruha, ICP e eketsehileng, khatello ea maikutlo, letsoalo le sa bonahaleng, ho bona lintho tse ling, maikutlo a mang a kelello.
Litho tsa maikutlo:pono e senyehileng, monko, ho utloa, tinnitus ea nakoana.
Tsamaiso ea pelo: Mathata a morethetho oa pelo, tachycardia, ho theola khatello ea mali, ho fofa nako le nako.
Hematopoietic sistimi: anemia, leukopenia, thrombocytopenia, granulocytopenia, thrombocytosis, leukocytosis.
Tsamaiso ea methapo: crystalluria, hematuria, glomerulonephritis, polyuria, dysuria, albinuria, phallo ea mali, nephritis, li fokotsehile tšebetso ea nitrogen ea liphihlelo.
Matšoao a ho kula: urticaria, ho hlohlona letlalong, ho ruruha le ho tsoa mali, ho hema ka mahlo, feberu ea lithethefatsi, edema, vasculitis, erythema nodosum, exanthema, jj.
Sistimi ea musculoskeletal: ramatiki, arthralgia, ropo ea tendon, tendovaginitis, myalgia, edema.
Liponahatso tse ling: candidiasis, kutlo ea leseli, ho fufuleloa, boemo ba bofokoli bo akaretsang.
Ho latela lipontšo tsa laboratori: ts'ebetso e eketsehileng ea li-transaminases tsa hepatic le phosphatase ea alkaline, hypoprothrombinemia, hyperuricemia, hypercreatininemia, hyperbilirubinemia, hyperglycemia
Ha e ts'oaroa, mokhoa oa lehae o ka hlaha.

Litaelo tsa ho sebelisa Ciprinol (mokhoa le litekanyetso)

Tsamaiso ka bobeli ea methapo ea tharollo ea Ciprinol le Ciprinol 500 mg (matlapeng) e beoa habeli ka letsatsi. Ka mefuta e bobebe ea mafu a tšoaetsanoang a moroto kapa oa ho hema, joalo joalo lets'ollo Tekanyetso e le 'ngoe ea lithethefatsi e behiloe 250 mg. Ka mefuta e matla ea mafu kapa ka tšoaetso e rarahaneng, mokuli o lokela ho nka 500 kapa 750 mg ea moriana.

Taeo ea Ciprinol 500 mg e fana ka hore ka lefu la gonorrhea moriana o nooa ena hang. Haeba tsamaiso ea methapo e etsoa, ho hlokahala hore ho kenngoe butle butle ka lethal dose ea 200-400 mg. Haeba mokuli a fumanoa a le leeme gonorrhea, 100 mg ea Ciprinol e kile ea tsamaisoa ka matla. Bakeng sa ho thibela mathata a tšoaetsanoang a ts'ebetso ea ts'oaetso, hoo e ka bang hora e le 'ngoe pele ho qala ts'ebetso ea ho buuoa, 200-400 mg ea Ciprinol e fuoa mokuli.

Haeba mokuli a e-na le tšenyo ea liphio, ka nako eo litekanyetso tsa letsatsi le letsatsi tsa lithethefatsi bakeng sa tsamaiso ea molomo li fokotsoa ka halofo.

U lokela ho noa matlapa pele ho lijo, ho bohlokoa ho noa moriana ona ka metsi a mangata.

Bongata

Ka overdose, pontšo ea matšoao a 'maloa e ka lemohuoa: ho tsekelaho opeloa ke hlooho, ho hlatsa, ho nyekeloa, lets'ollo. Haeba ho na le ts'ebeliso e matla ea ho feta tekano, ho akheha kelellong, ho thothomela, ho tsitsipana, lipontšo tsa hallucinations li ka etsahala.

Phekolo ea matšoao e etsoa, ho bohlokoa ho netefatsa hore mokuli o fumana mokelikeli o lekaneng, le ho hlatsoa mpa. Laxatives, khabone e sebetsang le eona lia ngolloa.

Tšebelisano

Haeba ho phekoloa ka nako e tšoanang Ciprinol le Didanosine, joale ho na le ho fokotseha ha ho kenngoa ha ciprofloxacin.

Tlas'a tšusumetso ea ciprofloxacin, khatello ea maikutlo e eketseha le halofo ea bophelo ba theophylline le li-xanthines tse ling li eketseha.

Ka kalafo e tšoanang e kopanang le ciprofloxacin le li-agents tsa hypoglycemic tsa molomo, hammoho le li-anticoagulants tse sa tobang, index ea prothrombin ea fokotseha.

Mohlomong nts'etsopele ea ho ts'oaroa ha u ntse u nka ciprofloxacin le NSAIDs.

Ho fufuleloa ha ciprofloxacin ho ka fokotseha ka kalafo e tšoanang ka li-antacid, lithethefatsi tse nang le aluminium, tšepe, zinki le ion ea magnesium. Ho bohlokoa ho netefatsa hore nako ea ho nka meriana ena ke bonyane lihora tse 4.

Haeba ciprofloxacin le cyclosporin li sebelisoa ka mokhoa o ts'oanang, joale phello ea nephrotoxic ea morao e ea matlafatsoa.

Metoclopramide activates ho amoheloa ha ciprofloxacin. Ka lebaka leo, nako ea ho fihlela mahloriso a eona a phahameng ka ho fetisisa a plasma e ea fokotseha.

Molemong oa phekolo ea ciprofloxacin le lithethefatsi tsa uricosuric, excretion ea ciprofloxacin e ea fokotseha 'me khatello ea tsona ho plasma e eketseha.

Ka tsamaiso e ts'oanang le lithethefatsi tse ling tse nang le phello ea antimicrobial, hangata synergism e hlokomeleha.

Litaelo tse khethehileng

Batho ba nang le lefu la ho akheha, lefu la sethoathoa, mafu a methapo ea mali le maloetse a bokong ba mmele, ciprofloxacin e ka laeloa feela moo ho nang le lipontšo tsa bohlokoa.

Haeba letšollo le matla le bonoa nakong ea kalafo, foromo e matla ha ea lokela ho qheleloa ka thoko.pseudomembranous colitis. Ha ho netefatsa ts'oaetso e joalo, ho bohlokoa ho hlakola sethethefatsi le ho phekola mokuli.

Haeba ho utloahala bohloko ba tendon, hammoho le matšoao a pele a tendovaginitis, nako ea kalafo e emisitsoe, joalo ka ha ho bile le maemo a ho ruruha ha tendon le ho phatloha nakong ea kalafo ka fluoroquinolones.

Ho ikoetlisa ka matla ha hoa lokela ho etsoa nakong ea kalafo ea ciprofloxacin.

Litekanyetso tse amohelehang tsa letsatsi le letsatsi ha lia lokela ho fetisoa, kaha kotsi ea crystalluria e eketseha. Ho boloka boemo ba moroto o tloaelehileng, ho bohlokoa ho nka mekelikeli e lekaneng nakong ea kalafo.

Nakong ea kalafo le lithethefatsi, mahlaseli a matla a UV ha a lokela ho lumelloa.

Ho batho ba nang le khaello ea glucose-6-phosphate dehydrogenase, khaello ea hemolytic e ka hlaha le tsamaiso ea Ciprinol.

Ha motho a phekoloa ka moriana o thibelang likokoana-hloko, o tlameha ho khanna makoloi ka hloko 'me a etsa tse ling tse amanang le tlhokomelo e eketsehileng.

Li-Analogs tse nang le phello e ts'oanang ke lithethefatsi Tsiprovin, Cyprrosan, Ciprolon, Cypropane, Cyproquin, Tariferide, Syflox, Perty, Lenaneo, Oflomak, Norilese, Oflocide, Negaflox, Norfacin le ba bang. Litaba tsena kaofela li ka fanoa feela kamora hore a lumelloe ke ngaka. Ho bohlokoa ho botsa ngaka ea hau hore na ke lithethefatsi life tse loketseng ho li khetha, le hore na ke lithibela-mafu kapa che.

Ka lithibela-mafu

Ho kopana ha ciprinol le ceftazidime le azlocillin ha ho phekoloa maloetse a halefisitsoeng ke Pseudomonas spp. kalafo ea ts'oaetso ea lefu la lefutso la streptococcal, motsoako le meslocillin, azlocillin, le lithibela-mafu tse ling tsa beta-lactam lia lumelloa. Molemong oa ts'oaetso ea tšoaetso ea staph, moriana o kopantsoe le vancomycin le isoxazolepenicillins. Molemong oa phekolo ea tšoaetso ea anaerobic, motsoako le metronidazole le clindamycin lia lumelloa.

Ka joala

Ha hoa lumelloa ho noa lino tse tahang nakong ea kalafo le Ciprinol.

Moriana o ka laeloa bakeng sa kalafo ea bana le bacha ba ka tlase ho lilemo tse 18 ha feela ho hlokahala kalafo le prophylaxis ea anthrax, hammoho le kalafong ea mathata a bakoang ke Pseudomonas aeruginosa ho bana ba nang le pulmonary cystic fibrosis.

Koprofloxacin

Ciprofloxacin: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Ciprofloxacinum

Khoutu ea ATX: S03AA07

Motsoako o sebetsang: Ciprofloxacin (Ciprofloxacinum)

Mohlahisi: PJSC Farmak, PJSC Technolog, OJSC Kyivmedpreparat (Ukraine), LLC Ozon, OJSC Veropharm, OJSC Synthesis (Russia), C.O. Khamphani ea Rompharm S.R.L. (Romania)

Ho nchafatsa litlhaloso le foto: 04/30/2018

Litheko makaleng a litlhare: ho tloha li-ruble tse 6.

Ciprofloxacin ke sethethefatsi se loantšang likokoana-hloko se nang le bongata bo bongata ba ketso ea bactericidal e tsoang sehlopheng sa fluoroquinolones.

Litlhahlobo mabapi le Ciprinol

Tlhahlobo ea bakuli e bontša hore ka thuso ea Ciprinol ba ile ba khona ho hlola tšoaetso e ileng ea qholotsa lefu lena. Leha ho le joalo, ho na le litlhahlobo tse ngata mabapi le ponahatso ea litla-morao nakong ea phekolo. Ka ho khetheha, dysbacteriosis, ts'oaetso ea fungal, le ho senyeha ha lipalo tsa mali tsa laboratori li boletsoe. Hoa hlokomeleha hore moriana o thibelang likokoana-hloko o lokela ho nkuoa nakong eo ngaka e laetsoeng ke ngaka.

Tekanyetso le tsamaiso

Tekanyetso e khethoa ke ngaka, ho latela boima ba lefu lena, mofuta oa ts'oaetso, boemo ba 'mele, lilemo (lilemo tse ka tlase ho 18 kapa tse fetang 60), boima ba mmele le ts'ebetso ea liphio.

Matšoao a ho sebelisoa

Litekanyetso tse le 'ngoe / tsa batho ba baholo ka letsatsi

Nako eohle ea kalafo

(ho nka kalafo kalafo ka mefuta ea boprisloloacacin)

Tšoaetso e tlase ea phefumoloho

Tšoaetso ea phepelo ea phefumoloho e holimo

Ho eketseha ha sinusitis e sa foleng

Ramatiki e sa feleng ea tšehetso ea maikutlo

Malignant otitis externa

Tšoaetso ea pampitšana ea urinary

Basali ba menoparance - hang 500 mg

Cystitis e rarahaneng, pyelonephritis e sa rarahanang

Bonyane matsatsi a 10, maemong a mang (mohlala, ka li-abscesses) - ho fihlela matsatsi a 21

Libeke tse 2-4 (a hlobaetsang)

Libeke tse 4-6 (tse sa foleng)

Tšoaetso ea lefutso

Gonococcal urethritis le cervicitis

Tekanyetso e le 'ngoe ea 500 mg

Orchoepididymitis le mafu a tšoaetsanoang a litho tsa kahare

Eseng matsatsi a ka tlase ho 14

Ts'oaetso ea ka mpeng le tšoaetso ea methapo

Letšollo le bakoang ke ts'oaetso ea baktheria, ho kenyelletsa le Shigella spp, ntle le mofuta oa Shigella dysenteriae I le kalafo ea moemphera ea letšollo le matla la baeti

Letšollo le bakoang ke mofuta oa Shigella dysenteriae I

Vibrio chlera lets'ollo

Tšoaetso ea intra-mpa ea ka mpeng

Letlalo le tšoaetso ea lisele tse bonolo

Mafu a kopaneng le a masapo

Thibelo le kalafo ea tšoaetso ho bakuli ba nang le neutropenia. Khothaletsa kopano le lithethefatsi tse ling

Phekolo e tsoela pele ho fihlela qetellong ea nako ea neutropenia.

Thibelo ea tšoaetso e kenang e bakoang ke meningitides ea Neisseria

Postexposure prophylaxis le kalafo ea koatsi. Phekolo e lokela ho qala hang hang ka mor'a ho tšoaetsoa kapa tšoaetso e netefalitsoeng.

Matsatsi a 60 ho tloha netefatso

Bakeng sa bakuli ba tsofetseng, tekanyo e fokotsoa ke 30%.

Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng: ho lokisoa ha lethal dose ha ho hlokehe.

Bakuli ba nang le ts'ebetso ea renal e sa sebetseng: lethal dose le lokisoa ho latela tafole:

250-500 mg hang hang ka lihora tse 24

250-500 mg hang ka mor'a lihora tse ling le tse ling tse 24 ka mor'a ho hlohlona

Litla-morao

Ka lehlakoreng la letlalo le lisele tse nyane: erythema multiforme le nodosum.

Ho tsoa ho tsamaiso ea pelo le pelo: Katoloso ea karohano ea QT, arrhythmias ea ventricular (ho kenyeletsoa mofuta oa pirouette), vasculitis, ho chesa haholo, migraine, ho akheha.

Ho tsoa pampiring ea mala le sebete: flatulence, anorexia.

Ho tloha lehlakoreng la tsamaiso ea methapo le psyche: ts'ebetso ea methapo e kholo ea methapo, ho hloka boroko, ho tsitsipana, ho thothomela, maemong a sa tloaelehang, ho ferekana ha maikutlo, ho ruruha, paresthesia le dysesthesia, ts'ebelisano e mpe, ho senyeha ha marapo, ho tsitsipana, maikutlo a tšabo le pherekano, lits'oants'o tse mpe tsa maikutlo, khatello ea maikutlo, maikutlo likhathatso tsa pono (diplopia, chromatopsia), tinnitus, tahlehelo ea nakoana ea kutlo. Haeba lintho tsena li etsahala, tlohela hang-hang lithethefatsi tseo 'me u tsebise ngaka e eang.

Ho tsoa ho sheropoietic system: thrombocytopenia, ka seoelo - leukocytosis, thrombocytosis, hemolytic anemia, anemia, agranulocytosis, pancytopenia (e behang bophelo kotsing), khatello ea masapo a mokokotlo (ho sokela bophelo).

Liphetoho le lintho tse ling: feberu ea lithethefatsi, hammoho le photosensitization, ka seoelo bronchospasm, ka seoelo aaphylactic makala, myalgia, lefu la Lyell, nephritis ea mahareng, hepatitis.

Sistimi ea musculoskeletal: ramatiki, molumo o eketsehileng oa mesifa le maratsoana. Ka seoelo - bofokoli ba mesifa, tendonitis, tendon ruptures (haholo-holo Achilles tendon), ho mpefatsa ha matšoao a myasthenia gravis.

Litho tse khahlisang: ho hema hanyane (ho kenyeletsoa maemo a asthmatic).

Boemo ka kakaretso: asthenia, feberu, ho ruruha, ho fufuleloa (hyperhidrosis).

Tšusumetso ho lipontšo tsa laboratori: hyperglycemia, phetoho kholisong ea prothrombin, keketseho ea mesebetsi ea amylase.

Likarolo tsa ts'ebeliso

Pele u qala kalafo, etela ngaka ea hau!

Haeba lets'ollo le matla le le lelelele le ba teng nakong ea kalafo kapa kamora 'kalafo, etela ngaka hanghang.

Haeba ho na le bohloko bo teng ka har'a 'mele oa "tendon", o lokela ho emisa ho nka meriana le ho ea ngakeng.

Tšusumetso ho bokhoni ba ho khanna koloi le ho sebetsa ka mekhoa

Nakong ea kalafo, motho o lokela ho hana ho etsa lintho tse kotsi tse hlokang ho tsepamisa mohopolo le ho potlakisa karabelo ea kelello le koloi.

Litlhokahalo tsa polokeho

Matšoafo a matla a methapo ea methapo ea pelo, kotsi ea mokokotlo, bokuli ba kelello, lefu la sethoathoa, lefu la sethoathoa, ho ruruha haholo le / kapa ho hloleha ha sebete, botsofe.

Mathata a pelo. Ciprofloxacin e lokela ho sebelisoa ka hloko ho kopantsoe le lithethefatsi tse eketsang nako ea QT (mohlala, Class I A le lithethefatsi tsa antiarrhythmic), kapa ho bakuli ba nang le menyetla ea ho eketseha ha nako ea pirouette arrhythmias (mohlala, ka nako e telele e tsebahalang ea karohano ea QT, hypokalemia e lokisitsoeng).

Sistimi ea musculoskeletal.Ho matšoao a pele a tendonitis (ho ruruha ho bohloko ha manonyeletso, ho ruruha), ts'ebeliso ea ciprofloxacin e lokela ho emisoa, ts'ebetso ea 'mele e lokela ho laoloa, hobane, ho na le kotsi ea ho phatloha ha tendon, mme o bone ngaka. Ciprofloxacin e lokela ho sebelisoa ka hloko ho bakuli ba nkang li-steroid tse nang le nalane ea mafu a tendon a amanang le quinolones.

Ciprofloxacin e ntlafatsa bofokoli ba mesifa ho bakuli ba nang le myasthenia gravis.

Sebelisa ka hlokolosi haeba ho na le nalane ea ho otloa, lefu la kelello (khatello ea maikutlo, psychosis), ho se sebetse hantle (le hona ho tsamaisana le ho hloleha ha sebete). Maemong a sa tloaelehang haholo, mathata a kelello a bonahatsoa ke liteko tsa ho ipolaea. Maemong ana, o lokela ho emisa hang hang ho nka ciprofloxacin mme o tsebise ngaka ea hau.

Ha u nka ciprofloxacin, karabelo ea photosensitization e ka hlaha, ka hona bakuli ba lokela ho qoba ho kopana le khanya ea letsatsi le khanya ea UV. Phekolo ho sena e lokela ho khaotsa.

Ho lokela ho ba hlokolosi ha u sebelisa ciprofloxacin le theophylline, methylxanthine, caffeine, duloxetine, clozapine, hobane keketseho ea khatello ea meriana ena maling e ka baka karabelo e khethehileng.

E le ho qoba nts'etsopele ea "crystalluria"

Mofumahali

Ha ho nooa ka molomo, ciprofloxacin e batla e amoheloa ka ho fetelletseng le ka potlako ho tsoa mokhoeng oa ho silila (haholo ho jejunum le duodenum). Ho ja ho thibela ho kenngoa, empa ha ho ame bioavailability le khatello e kholo. Bioavailability ke 50-85%, mme bophahamo ba phepelo ke 2-3.5 l / kg. Ciprofloxacin e tlama ho liprotheine tsa plasma ke hoo e ka bang 20-40%. Palo e phahameng ea ntho e 'meleng ha e nkuoa ka molomo e fihlelloa kamora metsotso e ka bang 60-90. Khatello e kholo e hokahane ka ho lekana le tekanyetso e nkuoeng le ho tekanyetso ea 1000, 750, 500 le 250 mg ke 5.4, 4.3, 2.4 le 1.2 μg / ml, ka ho latellana. Lihora tse 12 kamora ho kenella ka 750, 500 le 250 mg, litaba tsa ciprofloxacin ho plasma li fokotsoa ho 0,4, 0,2 le 0,1g / ml, ka ho latellana.

Ntho ena e tsamaisoa hantle liseleng tsa 'mele (ntle le linama tse ntlafalitsoeng mafura, mohlala, lithane tsa methapo). Likahare tsa eona liseleng li phahame makhetlo a 2 ho feta ho plasma ea mali. Metsoako ea phekolo e fumanoa letlalong, makhopho, mokelikeli oa methapo, methapo ea methapo, mokokotlo oa mokokotlo, lesapo la masapo le mesifa, mala, sebete, bile, lesapo la mokokotlo, liphio le tsamaiso ea mokokotlo, litho tsa mokokotlo oa mokokotlo le mokokotlo o monyane li-tubes, endometrium), lisele tsa tšoelesa ea senya, mokelikeli oa seminal, secretion ea bronchial, tishu ea matšoafo.

Ciprofloxacin e kenella ka har'a mokelikeli oa "cerebrospinal" maemong a manyane, moo litaba tsa teng li le sieo ha ts'ebetso ea ho ruruha methapong ea banna ke 6-10% ea tseo serumeng ea mali, 'me ka tsepamiso ea kelello e seng e le teng, ke 14- 37%.

Ciprofloxacin hape e kenella hantle ho limmal, pleura, mokelikeli oa potoloho, peritoneum le ka har'a placenta. Ho ts'oaroa ha eona ho neutrophils ea mali ho phahame makhetlo a 2-7 ho feta ho serum ea mali. K'holeseterole e tšelisoa ka har'a sebete ka hoo e ka bang ka 15-30%, 'me e ba le metabolites e sa sebetseng (formylcycrofloxacin, diethylcycrofloxacin, oxociprofloxacin, sulfociprofloxacin).

Bophelo ba halofo ea ciprofloxacin hoo e ka bang lihora tse 4, le ho hloleha ha renal ho sa feleng ho eketseha ho fihlela lihora tse 12. E hloekisoa haholo-holo ka liphio ka mokhoa oa secretion oa tubular le filtara ea tubular ka sebopeho se sa fetoheng (40-50%) le ka sebopeho sa metabolites (15%), se phomotsoang se hlahisoa ka ts'ebetso ea mpa. Karolo e nyane ea ciprofloxacin e hloekisoa lebeseng la matsoele. Hlakollo ea renal ke 3-5 ml / min / kg, mme botlalo ba botlalo ke 8-10 ml / min / kg.

Ho sa sebetseng hantle ha renal (CC ho feta 20 ml / min), tekanyo ea phallo ea ciprofloxacin ka liphio e ea fokotseha, empa ha e fokotse 'meleng ka lebaka la keketseho e lekantsoeng ea metabolism ea ntho ena le phello ea eona ka mpeng ea mpa.

Ha o kenya motsoako o kenelletseng oa moriana ka tekanyetso ea 200 mg, palo e phahameng ea koprofloxacin ea 2.1 μg / ml e fihlella kamora metsotso e 60. Kamora ts'ebetso ea methapo, litaba tsa ciprofloxacin ka har'a moroto nakong ea lihora tse 2 tsa pele kamora ho kenngoa, li ka makhetlo a 100 ho feta plasma ea mali, e fetang haholo tekanyetso ea inhibitory bakeng sa likokoana-hloko tse ngata tsa ts'oaetso ea mofets'e ea moroto.

Ha e sebelisoa ka ho qaqileng, ciprofloxacin e kenella ka har'a litho tsa leihlo: kamore ea ka ntle le cornea, haholoholo le ts'enyo ea "corneal epithelium". Ha e senyehile, ntho e bokellana ho eona ka likhakanyo tse ka felisang boholo ba lisosa tsa ts'oaetso ea corneal.

Kamora ts'ebetso e le 'ngoe, litaba tsa ciprofloxacin mongobo oa kamore e ka ntle ea leihlo e khethoa kamora metsotso e 10 mme ke 100 μg / ml. Khatiso e kholo ea mochini ka mongobo oa kamore ea kantle e fihlelloa kamora hora ea 1 mme e lekana le 190 μg / ml. Kamora lihora tse peli, khatello ea ciprofloxacin e qala ho fokotseha, empa phello ea eona ea antibacterial liseleng tsa methapo ea methapo e meleele e telele ebile e nka lihora tse 6, mongobo oa kamore ea kantle - ho fihlela lihora tse 4.

Kamora ho kenya, ho monya tsamaiso ea ciprofloxacin ho ka bonoa. Ha e sebelisoa ka mokhoa oa leihlo le theoha makhetlo a 4 ka letsatsi mahlong ka bobeli bakeng sa matsatsi a 7, karolelano ea ntho e teng ka har'a plasma ea mali ha e fetele 2-2.5 ng / ml, 'me khatello e phahameng e ka tlase ho 5 ng / ml.

Ts'ebeliso ea systemic (matlapa, tharollo ea infusion, tsepamisa maikutlo ha ho hlophisoa tharollo ea infusion)

Ho bakuli ba baholo, ciprofloxacin e sebelisoa bakeng sa kalafo le thibelo ea mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke likokoana-hloko tse qalang:

bronchitis (e sa foleng mokhatlong o matla le o hlobaetsang), bronchiectasis, pneumonia, cystic fibrosis le mafu a mang a amanang le ho hema,
frontitis, sinusitis, pharyngitis, otitis media, sinusitis, tonsillitis, mastoiditis le mafu a mang a litho tsa ENT,
pyelonephritis, cystitis le tšoaetso e 'ngoe ea liphio le pampitšana ea ho ntša metsi,
adnexitis, gonorrhea, prostatitis, chlamydia le mafu a mang a litho tsa pelvic le liphatsa tsa lefutso,
baktheria ea lisele tsa ka mpeng: (gastrointestinal tract), ducts ea bile, leqhetsoana le kenang kahare le mafu a mang a ka mpeng.
tšoaetso ea ka mpeng, ho chesa, makhopho, maqeba, phlegmon le mafu a mang a letlalo le lisele tse bonolo,
ramatiki, lefu la ho fokola ha masapo le mafu a mang a masapo le manonyeletso,
tšebetso ea ho buoa (ho thibela tšoaetso),
pulmonary anthrax (bakeng sa thibelo le kalafo),
tshwaetso kgahlano le semelo sa ho se sebetse hantle ho tlisoang ke kalafo ka lithethefatsi tsa immunosuppression kapa ka neutropenia.

Bakeng sa bana ba lilemo tse 5 ho isa ho 17, Ciprofloxacin e laetsoe ka mokhoa o hlophisehileng bakeng sa pulmonary cystic fibrosis bakeng sa kalafo ea mathata a bakoang ke Pseudomonas aeruginosa, hammoho le thibelo le kalafo ea pulmonary anthrax (Bacillus anthracis).

Tharollo ea infusion le ho tsepamisa mohopolo ha ho etsoa tharollo ea infusion ho boetse ho sebelisetsoa tšoaetso ea mahlo le ts'oaetso e matla ea mmele - sepsis.

Ho fuoa matlapa bakeng sa KFOR (selection decontamination e khethiloeng) bakeng sa bakuli ba nang le boits'ireletso ba mmele.

Ts'ebeliso ea lihlooho (marotholi a mahlo, marotholi a mahlo le tsebe)

Masapo a Ciprofloxacin a sebelisetsoa kalafo le thibelo ea tšoaetso e latelang e tšoaetsanoang e bakoang ke likokoana-hloko tse utluoang ke ciprofloxacin:

ophthalmology (marotholi a mahlo, marotholi a mahlo le a tsebe): blepharitis, subacute and acute conjunctivitis, blepharoconjunctivitis, keratitis, keratoconjunctivitis, meibomite (barele), dacryocystitis e sa foleng, tšoaetso ea baktheria ea makhopho a sefahleho, le tšoaetso ea lera ka lebaka la ts'oaetso ea leihlo. opereishene ea mahlo
otorhinolaryngology (marotholi a mahlo le a tsebe): media oa otitis ea kantle, kalafo ea mathata a tšoaetsanoang nakong ea ts'ebetso ea post.

Matlapa a koahetsoeng ka filimi

Matlapa a Ciprofloxacin a nooa ka molomo ka mor'a lijo, a koenya kaofela, ka mokelikeli o fokolang. Ho nka litafole ka mpeng e se nang letho ho potlakisa ho monngoa ha ntho e sebetsang.

Tekanyetso e khothalletsoang: 250 mg makhetlo a 2-3 ka letsatsi, le ts'oaetso e matla - 500-750 mg makhetlo a 2 ka letsatsi (nako e 1 ho lihora tse 12).

Melemo ho latela bokuli / boemo:

ts'oaetso ea pampitšana ea urinary: habeli ka letsatsi, 250-500 mg ka nako ea matsatsi a 7 ho isa ho a 10,
Ramatiki e sa foleng: habeli ka letsatsi ka 500 mg ka matsatsi a 28,
gonorrhea e sa rarahaneng: 250-500 mg hang,
ts'oaetso ea gonococcal hammoho le chlamydia le mycoplasmosis: habeli ka letsatsi (nako e le 1 ho lihora tse 12) 750 mg ka karolelano ea matsatsi a 7 ho isa ho a 10,
chancroid: habeli ka letsatsi, 500 mg ka matsatsi a 'maloa,
meningococcal koloeana ka nasopharynx: 500-750 mg hang,
kalafo e sa foleng ea salmonella: habeli ka letsatsi, 500 mg ka ngoe (haeba ho hlokahala, e nyolohela ho 750 mg) ka nako e fihlang ho matsatsi a 28,
ts'oaetso e matla (cyotic cystic fibrosis, ts'oaetso ea mokokotlo oa mpa, masapo, manonyeletso) e bakoang ke pseudomonads kapa staphylococci, pneumonia e hlohlelletsang lefu la methapo ea mafu ea genitourinary: habeli ka letsatsi (nako e le 'ngoe ka lihora tse 12) ka lethal dose ea 750 mg (nete ea kalafo bakeng sa osteomyelitis e ka nka matsatsi a 60
ts'oaetso ea ts'oaetso ea mokokotlo e bakoang ke Staphylococcus aureus: habeli ka letsatsi (nako e le ngoe ho lihora tse 12) ka tekanyetso ea 750 mg ka nako ea matsatsi a 7 ho isa ho a 28,
mathata a bakoang ke Pseudomonas aeruginosa ho bana ba lilemo li 5-17 ka pulmonary cystic fibrosis: habeli ka letsatsi ka 20 mg / kg (boholo ba letsatsi le letsatsi - 1500 mg) ka matsatsi a 10 ho isa ho a 14,
pulmonary anthrax (kalafo le thibelo): habeli ka letsatsi bakeng sa bana 15 mg / kg, batho ba baholo ba 500 mg (litekanyetso tse kholo: single - 500 mg, letsatsi le letsatsi - 1000 mg), nako ea kalafo - ho fihlela matsatsi a 60, qala ho sebelisa moriana E lokela ho ba hang hang kamora ts'oaetso (e belaelloa kapa e tiisitsoe).

Tekanyo e phahameng ea letsatsi le letsatsi ea ciprofloxacin ka ho se sebetse hantle ha renal:

creatinine clearance (CC) 31-60 ml / metsotso / 1.73 m 2 kapa serum ea tlhahiso ea mahlaseli a 1.4-1.9 mg / 100 ml - 1000 mg,
KK 2 kapa serum creatinine mahloriso> 2 mg / 100 ml - 500 mg.

Bakuli ho hemo- kapa peritoneal dialysis ba lokela ho nka lipilisi kamora kemiso ea dialysis.

Bakuli ba tsofetseng ba hloka ho fokotsa tekanyetso ea 30%.

Tharollo ea infusion, tsepamisa mohopolo ha ho etsoa tharollo ea infusion

Moriana o fanoa kahare kahare, butle, ka mothapo o moholo, hona ho fokotsa kotsi ea mathata a teng setsing sa ente. Ka tlhahiso ea 200 mg ea ciprofloxacin, infusion e nka metsotso e 30, 400 mg - 60 metsotso.

Pele o sebelisoa, tsepamiso ea mohopolo bakeng sa ho hlophisoa ha tharollo ea infusion e lokela ho theoleloa bophahamo ba bonyane ba 50 di ml ka tharollo tse latelang tsa tharollo: tharollo ea 0.9% sodium chloride, tharollo ea Ringer, 5% kapa 10% dextrose tharollo, 10% tharollo ea tharollo, le 5% dextrose ka 0.225 -0.45% tharollo ea sodium chloride.

Tharollo ea infusion e tsamaisoa e le 'ngoe kapa hammoho le tharollo e lumellanang ea infusion: tharollo ea 0,9% ea sodium chloride, Ringer le Ringer Lactate tharollo, 5% kapa 10% dextrose tharollo, 10% tharollo ea tharollo, 5% dextrose tharollo ho tsoa ho 0.225-0.45 % tharollo ea sodium chloride. Tharollo e fumanoeng kamora ho kopanya e lokela ho sebelisoa kapele kamoo ho ka khonehang bakeng sa ho boloka letsoalo la eona.

Haeba ho na le khakanyo e sa netefatsoang ka tharollo e 'ngoe / lithethefatsi, tharollo ea infrofloxacin infusion e tsamaisoa ka thoko. Matšoao a bonahalang a ho se lumellane ke pula, ho fifala kapa ho fifala ha metsi. Lenane la haedrojene (pH) la tharollo ea tlhahiso ea ciprofloxacin ke 3.5-4.6, ka hona, ha le lumellane ka tharollo / litokisetso tsohle tse sa tsitsang 'meleng kapa ka lik'hemik'hale litsing tse joalo tsa pH (tharollo ea heparin, penicillin), haholo-holo le li-pH-modifying agents lehlakoreng la alkaline. Ka lebaka la polokelo ea tharollo ka lithemparetjha tse tlase, ho ka etsoa sebopeho sa qhibilihang ka nako e telele mochesong oa kamore. Ha ho kgothaletswe ho boloka tharollo ea infusion ka sehatsetsing ebe oa e tsokolisa, kaha ke tharollo e hloekileng le e pepeneneng feela e loketseng ho sebelisoa.

Mokhoa o khothalelitsoeng oa litekanyetso tsa kalafo ea ciprofloxacin bakeng sa bakuli ba baholo:

tšoaetso ea pampitšana ea phefumoloho: ho latela boemo ba mokuli le ho teba ha tšoaetso - 2 makhetlo a 3 ka letsatsi, 400 mg
ts'oaetso ea genitourinary system: a hlobaetsang, a sa rarahane - makhetlo a 2 ka letsatsi ho tloha ho 200 ho isa ho 400 mg, e rarahaneng - makhetlo a 2 kapa a 3 ka letsatsi, 400 mg,
adnexitis, "bactericitis" e sa foleng ea baktheria kapa lefu la ho ruruha, "habeli kapa ka makhetlo a 3 ka letsatsi, 400 mg ka 'ngoe,
lets'ollo: makhetlo a 2 ka letsatsi, 400 mg ka ngoe,
tšoaetso e ngoe e thathamisitsoeng karolong ea "Indication for Use": makhetlo a 2 ka letsatsi, 400 mg ka 'ngoe,
tšoaetso e matla e behang bophelo kotsing, haholoholo e bakoang ke Staphylococcus spp., Pseudomonas spp., streptococcus spp. ,
mofuta oa anthrax ea pulmonary (inhalation): makhetlo a 2 ka letsatsi, 400 mg ka nako ea matsatsi a 60 (bakeng sa kalafo le thibelo).

Khalemelo ea tekanyo ea ciprofloxacin ho bakuli ba tsofetseng e etsoa tlase, ho latela botebo ba lefu lena le sesupo sa QC.

Bakeng sa kalafo ho bana ba lilemo li 5 - 17, mathata a Pseudomonas aeruginosa a bakoang ke pulmonary cystic fibrosis e khothalletsoa makhetlo a 3 ka tekanyetso ea letsatsi ea 10 mg / kg (boholo ba letsatsi le letsatsi - 1200 mg) bakeng sa matsatsi a 10-14. Bakeng sa kalafo le thibelo ea anthrax ea pulmonary, infusions tse 2 ka letsatsi tsa 10 mg / kg ea ciprofloxacin li khothalletsoa (boholo bo le bong - 400 mg, letsatsi le letsatsi - 800 mg), nete - matsatsi a 60.

Tekanyo e phahameng ea letsatsi le letsatsi ea ciprofloxacin ka ho se sebetse hantle ha renal:

creatinine clearance (CC) 31-60 ml / min / 1.73 m 2 kapa serum ea tlhahiso ea mahlaseli a 1.4-1.9 mg / 100 ml - 800 mg,
KK 2 kapa serum creatinine mahloriso> 2 mg / 100 ml - 400 mg.

Bakeng sa bakuli ba nang le hemodialysis, ciprofloxacin e tsamaisoa hang ka mor'a seboka.

Nako e tloaelehileng ea kalafo:

gonorrhea e hlobaetsang le e sa rarahaneng - 1 letsatsi,
ts'oaetso ea liphio, pampitsana ea ho ntša metsi 'meleng le mpa ea mpa - ho fihlela matsatsi a 7,
osteomyelitis - matsatsi a sa feteng 60,
ts'oaetso ea lefua la streptococcal (ka lebaka la kotsi ea mathata a morao) - bonyane matsatsi a 10,
tshwaetso khahlano le nalane ea boits'ireletso bo bakoang ke kalafo ka lithethefatsi tsa immunosuppression - nakong eohle ea neutropenia,
tšoaetso e 'ngoe - matsatsi a 7-14.

Ho theoha ha mahlo, leihlo le tsebe

Ka ts'ebetso ea mahlo a mahlo, marotholi a ciprofloxacin (ophthalmic, ophthalmic le tsebe) a kenngoa ka har'a sac ea conjunctival.

Mokhoa oa ho koetlisa ho latela mofuta oa tšoaetso le ho teba ha ts'ebetso ea ho ruruha:

baktheria e matla ea baktheria e hlabang, blepharitis (e bonolo, e scaly le ulcerative), meibomites: 1-2 e theoha makhetlo a 4-8 ka letsatsi matsatsi a 5-14,
keratitis: Ho theoha makhetlo a 6 ka letsatsi ka matsatsi a 14-31,
leqeba la likokoana-hloko tsa lera la mokokotlo: Letsatsi la 1 - 1 le theoha metsotso e meng le e meng e 15 bakeng sa lihora tse 6 tsa pele tsa kalafo, ebe o theoha metsotso e meng le e meng e 30 ka nako ea lihora tse 2, ka la 2 - ho isa 1 hora e ngoe le e ngoe nakong ea lihora tse matla, 3 ho isa ho 14 Matsatsi - nakong ea lihora tse tsohang, theoha 1 lihora tse ling le tse ling. Haeba epithelization e sa etsahale kamora matsatsi a 14 a kalafo, kalafo e lumelletsoe ho tsoela pele matsatsi a mang a 7,
dacryocystitis e hlobaetsang: 1 le theoha makhetlo a 6-12 ka letsatsi ka karolelano ea matsatsi a sa feteng 14,
likotsi tsa mahlo, ho kenyelletsa le litopo tsa kantle ho naha (thibelo ea mathata a tšoaetsanoang): ho theoha makhetlo a 4-8 ka letsatsi matsatsi a 7-14,
Boitokisetso ba ts'ebetso: ho theola makhetlo a 4 ka letsatsi matsatsi a mabeli pele ho ts'ebetso, ho theoha makhetlo a 5 le nako ea metsotso e 10 pele ho ts'ebetso,
nako ea ts'ebetso (thibelo ea mathata a tšoaetsanoang): theoha makhetlo a 4-6 ka letsatsi nako eohle, hangata ho tloha matsatsing a 5 ho isa ho a 30.

Ho otorhinolaryngology, lithethefatsi (marotholi a mahlo le a tsebe) li kenngoa ka har'a canal ea kantle ea libuka, kaha esale e e hloekisitse ka hloko.

Mokhoa o khothalelitsoeng oa dosing: makhetlo a 2-5 ka letsatsi (kapa hangata, ha ho hlokahala) bakeng sa marotholi a 3-4. Nako ea kalafo ha ea lokela ho feta matsatsi a 5-10, ntle le haeba lipalesa tsa lehae li le bonolo, ebe ho atoloha ha thupelo ho lumelloa.

Bakeng sa ts'ebetso, ho khothalletsoa ho tlisa tharollo mochesong oa kamore kapa mocheso oa 'mele bakeng sa ho qoba ho tsosa ka mokhoa o ts'oanang. Mokuli o lokela ho robala ka lehlakoreng la hae, ka lehlakoreng la tsebe e amehileng, 'me a lule sebakeng sena metsotso e 5-10 ka mor'a ho kenngoa.

Ka linako tse ling, kamora ho hlatsoa lehae la patsi ea kantle ho naha, ho lumelloa ho kenya swab ea k'hothone e kenngoeng ka tharollo ea Ciprofloxacin tsebeng ebe e e boloka e le teng ho fihlela tlhahiso e latelang.

Ho sebelisana le lithethefatsi

Ka lebaka la ts'ebetso e phahameng ea pharmacological ea Ciprofloxacin le kotsi ea litlamorao tsa ts'ebelisano ea lithethefatsi, qeto mabapi le tsamaiso e kopanetsoeng le lithethefatsi tse ling / litlhare li etsoa ke ngaka e eang.

Analogues ea ciprofloxacin ka sebopeho sa matlapa: Quintor, Procipro, Ceprova, Ciprinol, Ciprobay, Ciprobid, Ciprodox, Ciprolet, Cipropan, Cifran, jj.

Likhatiso tsa tharollo ea infusion le ho tsepamisa mohopolo ho lokiseng tharollo ea infusion ea Ciprofloxacin: Basigen, Ififpro, Quintor, Procipro, Tseprova, Ciprinol, Tsiprobid, jj.

Li-analoggs tsa ophthalmic / ocular le tsebe li theoha Ciprofloxacin: Betaciprol, Rocip, Ciprolet, Ciprolon, Cipromed, Ciprofloxacin-AKOS.

Lipehelo le maemo a polokelo

Boloka sebakeng se omileng, se lefifi ka lithemparetjha ho fihlela ho 25 ° C, tharollo ea infusion, tsepamisa mohopolo le marotholi - u se ke oa bata. Qoba hole le bana.

Bophelo ba matlapa a matlapa ke ho tloha ho lilemo tse peli ho isa ho tse 5 (ho latela moetsi), tharollo le ho tsepamisa maikutlo - lilemo tse 2, leihlo / leihlo le tsebe le theoha - lilemo tse 3.

Kamora ho bula botlolo, marokho a leihlo le tsebe ha a fetise matsatsi a 28, mahlo a theoha ka nako e sa feteng matsatsi a 14.

Matlapa a 250 kapa 500 mg

Matlapa a lokela ho nooa ka mpeng e se nang letho, o se ke oa hlafuna le ho noa ka metsi. Tekanyetso e tloaelehileng ea lithethefatsi ke 250 mg makhetlo a 2-3 ka letsatsi. Ho ts'oaetso e matla, ho kgothaletswa ho nka 500-750 mg ea moriana o mong le o mong ka lihora tse 12 (makhetlo a 2 ka letsatsi).

Litekanyetso tse khothalelitsoeng tsa ciprofloxacin li ipapisitse le mofuta oa ts'oaetso, botebo ba lefu lena, boemo ba 'mele, ts'ebetso ea liphio, boima le lilemo tsa mokuli.

Ha ho phekoloa tšoaetso e sa rarahanang ea liphio le pampitšana ea ho ntša metsi, 250 mg ea Ciprinol e lokela ho nooa makhetlo a 2 ka letsatsi bakeng sa matsatsi a 7- 7, ka ts'oaetso e rarahaneng - 500 mg makhetlo a 2 ka letsatsi ka matsatsi a 3.

A sa foleng a prostatitis, 500 mg ea moriana o fuoa makhetlo a 2 ka letsatsi ka matsatsi a 28.

Bakeng sa kalafo ea mafu a tšoaetsanoang le a tšoaetsanoang a pampiri e fokolang ea ho hema ka mokhoa o leka-lekaneng, ho kgothaletswa ho nka 250-500 mg ea Ciprinol makhetlo a 2 ka letsatsi. Ha kalafo ea linyeoe tse mpe haholo, lethal dose le eketseha ho 750 mg makhetlo a 2 ka letsatsi.

Ho gonorrhea e matla, ho fanoa ka tekanyo e le 'ngoe ea 250-500 mg ea ciprofloxacin. Haeba ts'oaetso ea gonococcal e tsamaisana le mycoplasma le chlamydia, joale lethal dose le khothalletsoang ke 750 mg ea moriana ka mong lihora tse 12 (nako ea tsamaiso e tsoa matsatsing a 7 ho isa ho a 10).

Ka chancroid, ho kgothaletswa ho nka 500 mg ea Ciprinol makhetlo a 2 ka letsatsi matsatsi a 'maloa.

Tekanyetso e le 'ngoe ea ciprofloxacin e nang le Salmonellatyphi ke 250 mg, leha ho le joalo, ha ho hlokahala, e ka eketseha ho 500 kapa 750 mg. Nako ea ho amoheloa hangata ke makhetlo a 2 ka letsatsi, nako ea kalafo e fihla ho libeke tse 4.

Ho mafu a tšoaetsanoang a bokhoni ba ka mpeng, osteomyelitis le tšoaetso e 'ngoe e matla, 750 mg ea moriana o fuoa makhetlo a 2 ka letsatsi. Nako ea kalafo ea osteomyelitis e ka nka likhoeli tse peli.

Ho alafa tšoaetso ea ka mpeng e bakoang ke Staphylococcus aureus, 750 mg ea Ciprinol e lokela ho nkuoa lihora tse ling le tse ling tse 12 ka matsatsi a 7- 28.

Ka letšollo la baeti, 500 mg ea ciprofloxacin e beoa makhetlo a 2 ka letsatsi bakeng sa matsatsi a 5-7 (maemong a mang ho fihlela matsatsi a 14).

Ts'oaetsong ea tsebe, 'metso le nko, lethal dose le ipapisitse le boima ba lefu lena: ho lekana - ho tloha ho 250 ho isa ho 500 mg, le boima - ho tloha ho 500 ho isa ho 750 mg. Moriana o nooa habeli ka letsatsi.

Bakeng sa kalafo ea mathata a bakoang ke Pseudomonas aeruginosa ho bana ba nang le pulmonary cystic fibrosis ho tloha ho lilemo tse 5 ho isa ho tse 17, ho khothalletsoa ho sebelisa ciprofloxacin ka litekanyetso tsa 20 mg ka kilo e le 1 (boima bo boholo ke 1500 mg). Maemong a joalo, Ciprinol e nkuoa makhetlo a 2 ka letsatsi matsatsi a 10-14.

Thibelo ea tšoaetso nakong ea ts'ebetso ea opereishene, 500-750 mg ea Ciprinol e laetsoe lihora tse 1-1,5 pele ho buuoa.

Bakeng sa thibelo le kalafo ea koatsi, bakuli ba baholo ba fuoa 500 mg ea ciprinol makhetlo a 2 ka letsatsi, bana - 15 mg ea ciprofloxacin ka kilo e le 'ngoe ea boima ba' mele makhetlo a 2 ka letsatsi. Hoa hlokahala ho qala ho nka moriana hang ka mor'a ts'oaetso (ho belaelloa kapa ho netefatsoa). Boemong ba pele ba kalafo, ho khothalletsoa ho sebelisa mekhoa ea botsoali. Nako eohle ea kalafo ke matsatsi a 60.

Ka tloaelo, nako ea kalafo ka lithethefatsi e tsoa matsatsing a 7 ho isa ho a 10, leha ho le joalo, kamora hore mocheso o tloaele, ho lula ho hlokahala hore o nke Ciprinol matsatsi a mang a 3.

Bakuli ba nang le ts'oaetso e matla ea methapo ea kutlo ba lokela ho fumana tekanyetso ea halofo ea moriana. Phekolo ea bakuli ba nang le bothata ba ho phekoloa ke a reistile ho sa feleng, ho khothaletsoa mofuta o latelang oa litekanyetso:

KK e fetang 50 di ml / min - tekanyetso e tloaelehileng,
CC ho tloha ho 30 ho isa ho 50 ml / min - ho tloha ho 250 ho isa ho 500 mg ea Ciprinol hang ka mor'a lihora tse 12,
KK ho tloha ho 5 ho isa ho 29 ml / min - ho tloha ho 250 ho isa ho 500 mg ea moriana hang ka lihora tse 18,
bakuli ba ntseng ba qoelisoa ka peritoneal dialysis kapa hemodialysis - ho tloha ho 250 ho isa ho 500 mg ea ciprofloxacin nako e 1 ka lihora tse 24

Matlapa a 750 mg

Matlapa a tlameha ho nkuoa kamora lijo, u se ke oa hlafuna le ho noa ka metsi. Litekanyetso tse khothalelitsoeng tsa ciprofloxacin li ipapisitse le mofuta oa ts'oaetso, botebo ba lefu lena, boemo ba 'mele, ts'ebetso ea liphio, boima le lilemo tsa mokuli.

Maemong a mafu a tšoaetsanoang le a tšoaetsanoang a pampiri e fokolang ea ho phefumoloha e nang le tekanyo e matla makhetlo a 2 ka letsatsi, ho fanoa ka 750 mg ea moriana.

Ka pyelonephritis e rarahaneng, ho kgothaletswa ho nka makhetlo a 750 mg makhetlo a 2 ka letsatsi. Nako ea kalafo e tsoa matsatsing a 10, 'me maemong a ikhethang (ka mohlala, le lekhopho la liphio), nako ea kalafo e ka feta matsatsi a 21.

Ho tšoaetso e matla ea letlalo le lisele tse bonolo, moriana o nooa habeli ka letsatsi bakeng sa 750 mg. Nako ea kalafo ke matsatsi a 7-14.

Mefuteng e matla ea tšoaetso ea masapo le ea kopane (septic arthritis, osteomyelitis), 750 mg ea Ciprinol e beoa makhetlo a 2 ka letsatsi. Nako ea kalafo ea osteomyelitis e fihla ho likhoeli tse peli.

Bakeng sa tšoaetso ea litho tsa botona le tsa botšehali, moriana o khothalletsoa ho nooa makhetlo a 2 ka letsatsi, 750 mg ka 'ngoe.

Bakeng sa tšoaetso ea bokhachane ba mpeng bo bakoang ke libaktheria tse se nang gram, khafetsa ho nka ciprofloxacin makhetlo a 2 ka letsatsi ho 750 mg.

Maemong a tšoaetso e khahlanong le semelo sa ts'oaetso ea mmele, moriana o laetsoe hammoho le li-antibacterial agents makhetlo a 2 ka letsatsi, 750 mg ka 'ngoe.

Bakeng sa prophylaxis ea ts'oaetso nakong ea ts'ebetso ea ts'ebetso ea opereishene, lihora tse 1-1,5 pele ho ts'ebetso, ho kenoa ka 500-750 mg ea ciprofloxacin ho bontšoa.

Botebo ba lefu lena bo ama nako ea kalafo, leha ho le joalo, kamora hore mocheso o tloaele, mocheso o tlameha ho tsoelapele bonyane matsatsi a mararo. Nako e tloaelehileng ea kalafo ke matsatsi a 7-10.

Sebelisa bongoaneng

Ka thibelo le kalafo ea anthrax ea pulmonary ho bana ba lilemo li 5-17, 10 mg ea ciprofloxacin ka kilo e le 'ngoe ea boima ba' mele e beoa makhetlo a 2 ka letsatsi. Tekanyetso e phahameng ea letsatsi le letsatsi bakeng sa tsamaiso ea methapo ke 800 mg (boholo ba lethal dose le le leng ke 400 mg).

Bakeng sa bakuli ba nang le pulmonary cystic fibrosis ea bana ba lilemo li 5-17, kalafong ea mathata a bakoang ke Pseudomonas aeruginosa, 10 mg ea ciprofloxacin ka kilo e le 'ngoe ea boima ba' mele e beoa lihora tse ling le tse ling tse 8 (ha a fanoa kahare ho lihora tse ling le tse ling tse 8, tekanyo e phahameng ha ea lokela ho feta 400 mg). Nako ea kalafo e tsoa matsatsing a 10 ho isa ho a 14.

Ka mosebetsi o sa sebetseng oa renal

Bakuli ba nang le methapo ea kutlo ea ts'ebetso ea liphio ba lokela ho fumana tekanyetso ea halofo ea lithethefatsi (bona "Litekanyetso le Tsamaiso: 250 le 500 mg Tablets").

Ka mahloriso a serum creatinine lipakeng tsa 1,4 / 100 ml le 1,9 mg / 100 ml kapa tumello ea creatinine ea 31 ml / min / 1.73 sq. m ho isa ho 60 ml / min / 1,73 sq. m boholo ba letsatsi le letsatsi lethal dose la moriana ke 800 mg.

Bakeng sa kalafo ea bakuli ba nang le bothata ba ho hlaba ka thata ba renaline (clearinine clearance - ho fihlela ho 30 ml / min / 1.73 sq. M, khakanyo ea creatinine - ho feta 2 mg / 100 ml), halofo ea tekanyetso ea letsatsi le letsatsi (eseng ho feta 400 mg ka letsatsi) e laetsoe. Ka peritonitis ho bakuli ba tsoang ho outpatient peritoneal dialysis, ho ka etsahala ho tsamaisa ciprofloxacin intraperitoneally makhetlo a 4 ka letsatsi, 50 mg ka ho ya ka litara e le 1 ea dialysate.

Litlhahlobo mabapi le Ciprinol

Tlhahlobo ea Ciprinol e bonts'a katleho ea moriana ona - e thusa ho hlola ts'oaetso e ileng ea qholotsa lefu lena. Ka nako e ts'oanang, basebelisi ba bangata ba tlaleha nts'etsopele ea litla-morao (ho senyeha ha lipalo tsa mali tsa laboratori, tšoaetso ea fungal, dysbiosis). Hoa hlokomeleha hore moriana o lokela ho nooa feela nakong ea nako e boletsoeng ke ngaka.

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Sebopeho le mofuta oa tokollo

Setlhare se fumaneha ka mefuta e 'maloa - marotholi a mahlo le tsebe, matlapa, ente, setlolo sa mahlo. Ho latela litaelo, motheo oa e 'ngoe le e' ngoe ea tsona ke ciprofloxacin hydrochloride. Ke litekanyetso tsa sehlahisoa sena le likarolo tse thusang li fapana. Sebopeho sa moriana se hlalosoa tafoleng:

Sebopeho sa tokrofloxacin (lebitso la Latin - ciprofloxacin)

Matlapa a ho sebelisoa ka molomo

250, 500 kapa 750 mg

Ho koaheloa ka koae ea filimi, ponahalo e latela moqapi le litekanyetso.

silica colloidal anhydrous,

Leihlo le tsebe le theoha 0,3%

Mokelikeli o se nang mmala, o pepeneng kapa o bokhutšoaane hanyane. E rekisetsoa ka libotlolong tsa polymer tsa dropper tsa 1 ka lebokoseng.

Tharollo ea infusion ka ampoules bakeng sa ba tlohelang

Mokelikeli o sa bonahaleng kapa o nang le 'mala o bosesaane ho li-vials tsa 100 ml.

hlapolla hydrochloric acid,

E fumaneha ka meqomo ea aluminium, e pakiloeng ka har'a karete ea karete.

Nahanela tharollo ea infusion

Botala bo botala bo bosehla bo bosehla kapa bo se nang 'mala bo 10 ml ka botlolong. Li rekisoa ka likotoana tse 5 ka pakete e ngoe.

disodium edetate dihydrate,

metsi bakeng sa ente

Melemo ea pharmacological

Ho ea ka litaelo, mefuta eohle ea lithethefatsi e na le pono e fapaneng ea antibacterial ea ketso e khahlano le libaktheria tse ntle tsa gram le tse mpe tsa aerobic le anaerobic, joalo ka:

Lefuba la Mycobacterium,
Brucella spp.,
Listeria monocytogene,
Mycobacterium kansasii,
Chlamydia trachomatis,
Legionella pneumophila,
Mycobacterium avium-intracellulare.

Staphylococci e hananang le methicillin ha e amehe ka ciprofloxacin. Ha ho na phello ho Treponema pallidum. Streptococcus pneumoniae le Enterococcus faecalis libaktheria li nahanela seriti ka mokhoa o itekanetseng. Setlhare se sebetsa ho likokoana-hloko tsena ka ho thibela DNA ea bona le ho hatella ligrase ea DNA. Ntho e sebetsang e kenella hantle ho mokelikeli oa mahlo, mesifa, letlalo, bile, plasma, lymph. Kamora ts'ebeliso ea ka hare, bioavailability ke 70%. Ho monya ha likarolo ho ameha hanyane ke takatso ea lijo.

Tekanyetso le tsamaiso

Ngoliso ea kalafo e khethoa ke mofuta le botebo ba ts'oaetso. Ciprofloxacin - litaelo tsa tšebeliso ea eona li bonts'a mekhoa e 3 ea ts'ebeliso. Moriana o ka sebelisoa ka ntle, kahare kapa ka ente. Ts'ebetso ea manonyeletso e boetse e ama litekanyetso, 'me ka linako tse ling botsofali le boima ba' mele. Bakeng sa batho ba baholo le bana, e tlaase haholo. Ka hare ho pilisi, ho khothalletsoa ho e etsa ka mpeng e se nang letho. Liente li sebelisoa maemong a boima haholo, e le hore setlhare se sebetsa ka potlako. Ho latela litaelo pele ho kopano, ho etsoa tlhahlobo bakeng sa kutloisiso ea pathogen ho ea meriana.

Litla-morao le lithethefatsi tse ngata

Monyetla oa mefuta eohle ea phekolo ke mamello e ntle, empa bakuli ba bang ba sa na le karabelo e bohloko, e kang:

hlooho e bohloko
thothomela
ho tsekela
mokhathala
tsosa.

Hangata hona ke karabelo e mpe mabapi le ts'ebeliso ea ciprofloxacin. Taeo e boetse e bonts'a litla-morao tse sa tloaelehang. Maemong a mang, bakuli ba ka ba le:

intracranial hypertension,
maqhubu
mofufutso
bohloko ba ka mpeng
ho nyekeloa ke pelo kapa ho hlatsa
hepatitis
tachycardia
khatello ea maikutlo
letlalo la letlalo le boreleli
botlaela.

Ho ahloloa ke litekolo, maemong a ikhethang, bakuli ba fetoha bronchospasm, anaphylactic makala, lefu la Lyell, creatinine, vasculitis. ha e sebelisoa ho otology, moriana o ka baka tinnitus, dermatitis, hlooho ea hlooho. U sebelisa moriana ho phekola mahlo, o ka ikutloa:

maikutlo a tsoang kantle ho naha ka leihlong, ho hloka botsitso le ho tepella,
ponahalo ea kobo e tšoeu leseling la mahlo,
hypjunctival hyperemia,
lacrimation
fokotseha ha leihlo le bonoang,
Photophobia
Ho ruruha ha lintshi,
lits'oants'o tsa cornea.

Lipehelo tsa thekiso le polokelo

Mefuta eohle ea ho lokolla lithethefatsi e fanoa feela ka taelo ea ngaka.Sebaka sa polokelo ea bona e lokela ho ba thata ho fihlella bakeng sa bana mme ba hlekiloe hampe. Ho latela litaelo, mocheso o khothalletsoang ke mocheso oa kamore. Bophelo ba Shelf bo itšetlehile ka mofuta oa tokollo mme ke: