Amoxicillin Sandoz - litaelo tsa semmuso bakeng sa tšebeliso

Amoxicillin Sandoz: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Amoxicillin Sandoz

Khoutu ea ATX: J01CA04

Motsoako o sebetsang: amoxicillin (Amoxicillin)

Mohlahisi: Sandoz, GmbH (Sandoz, GmbH) (Austria)

Ho nchafatsa litlhaloso le foto: 07/10/2019

Litheko makaleng a litlhare: ho tloha li-ruble tse 123.

Amoxicillin Sandoz ke lithibela-mafu tse tsoang sehlopheng sa penisilini tsa semisynthetic.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - matlapa a koahetsoeng ka filimi: oblong (0.5 g e ngoe le e ngoe) kapa oval (1 g e le 'ngoe) li-pcs ho lithutsoana, ka lebokoseng la mekotla ea 1 le lilakane tsa tšebeliso ea Amoxicillin Sandoz, lipetlele bakeng sa lipetlele - lebokoseng la matlapa a 100 matlapa a 10, litekanyetso tsa 1 g: 6 le li-10 likhomphutha ka lilakane, likhabotong tse peli le malebela ho moriana, ho pakela lipetlele - ka lebokoseng la likarete tse 100).

Letlapa la 1

• ntho e sebetsang: amoxicillin (ka sebopeho sa hydrocrate) - 0.5 kapa 1 g,
• likarolo tse thusang: microcrystalline cellulose, povidone, sodium carboxymethyl starch (mofuta A), magnesium stearate,
• filimi sheath: hypromellose, talc, titanium dioxide.

Mofumahali

Amoxicillin - motsoako o sebetsang oa lithethefatsi - ke penicillin e entsoeng ka halofo e nang le litlamorao tsa bactericidal.

Mochine oa ts'ebetso o bakoa ke bokhoni ba amoxicillin ba ho senya membrane ea sele ea baktheria sethaleng sa ho ikatisa. Lithethefatsi ka ho khetheha li thibela li-enzyme tsa membrane ea lisele tsa likokoana-hloko (li-peptidoglycans), li fella ka hore li losesane le ho shoa.

Amoxicillin Sandoz e sebetsa khahlano le libaktheria tse latelang:

• Likokoana-hloko tse nang le likokoana-hloko tsa Gram tse ntle: Streptococcus spp. (ho kenyeletsoa le S. pneumoniae), Listeria monocytogenes, Enterococcus faecalis, Bacillus anthracis, Staphylococcus spp. (ntle le penicillinase e hlahisa likarolo), Corynebacterium spp. (ntle le C. jeikeium),
• gram-negative aerobic microorganisms: Neisseria spp., Borrelia spp., Shigella spp., Helicobacter pylori, Escherichia coli, Salmonella spp., Campylobacter, Haemophilus spp., Proteus mirabilis, Leptospira spp, Treponema spp.
• Libaktheria tsa anaerobic: Fusobacterium spp., bacteriides melaninogenicus, Peptostreptococcus spp., Clostridium spp.,
• Tse ling: Chlamydia spp.

Amoxicillin Sandoz ha e sebetse khahlanong le likokoana-hloko tse latelang.

• Baktheria ea aerobic e thusang: Graphylococcus (likhetla tse hlahisang lactamase),
• Baktheria ea gram-negative aerobic: Klebsiella spp., Proteus spp., Acinetobacter spp., Pseudomonas spp., Serratia spp., Moraxella catarrhalis, Enterobacter spp, Providencia spp.,
• Libaktheria tsa anaerobic: Bacteroides spp.,
• Ba bang: Rickettsia spp., Mycoplasma spp.

Mofumahali

Kamora tekanyetso ea molomo ea Amoxicillin Sandoz 0.5 g, mahlaseli a plasma a lithethefatsi a tloha ho 6 ho isa ho 11 mg / L. Nako ea ho fihlela mahloriso a mangata a plasma ke lihora tse 1-2. Ho ja ha ho ame ho amoheloa (lebelo le degree). Ho ba le bioavailability e felletseng ho itšetleha ka tekanyo ea tlhaho mme e ka ba 75-90%.

15-25% ea lethal dose e amohelang e hokahana le liprotheine tsa plasma. Amoxicillin e kenella ka potlako ka har'a bile, secretion ea bronchial, tishu ea matšoafo, moroto, mokelikeli oa tsebe e bohareng. Ka bongata bo kenella ka har'a mokelikeli oa "cerebrospinal fluid", ha ho na ts'oaetso ea meninge, ho seng joalo se ka har'a mokelikeli oa "cerebrospinal fluid" se ka fihla ho 20% ea mahlaseli a plasma. E kenella ka har'a placenta, ka bongata bo nyane ka lebese la matsoele.

Ho fihla ho 25% ea tekanyetso e amoheloang ea lithethefatsi e tšelisoa ka ho thehoa ha penicilloic acid, e se nang mesebetsi ea meriana.

E bonts'itsoe: 60-80% ea lethal dose - ke liphio ha lia fetoha bakeng sa lihora tse 6-8 kamora ho nka Amoxicillin Sandoz, e nyane - le bile.

Half-life (T_½) ke lihora tse 1‒1.5, ka ho se sebetse hantle ha 'mele oa' mele ho ka fapana ka lihora tse 5‒20.

Amoxicillin e tlosoa 'meleng nakong ea hemodialysis.

Foromo ea boholo:

matlapa a koahetsoeng ka filimi.

Tlhaloso

Letlapa la blongonvex ea Oblong (litekanyetso tsa 0.5 g) kapa oval (litekanyetso tsa 1,0 g) biconvex, filimi e koahetsoeng ho tloha ho tšoeu ho isa ho 'mala o moputsoa hanyane, e nang le lintlha ka mahlakore ka bobeli.

Letlapa le le leng la 0.5 g le 1.0 g le na le:
Ntho ea bohlokoa
Lintho tse sebetsang: amoxicillin (ka sebopeho sa amoxicillin trihydrate) 500.0 mg (574.0 mg) le 1000.0 mg (1148.0 mg), ka ho latellana.
Baeti: magnesium stearate 5.0 mg / 10,0 mg, povidone 12.5 mg / 25.0 mg, sodium carboxymethyl starch (mofuta A) 20,0 mg / 40.0 mg, microcrystalline cellulose 60,5 mg / 121 mg.
Filimi sheath: titanium dioxide 0,340 mg / 0.68 mg, talc 0.535 mg / 1.07 mg, hypromellose 2.125 mg / 4.25 mg.

Matšoao a ho sebelisoa

Amoxicillin Sandoz e sebelisoa kalafo ea mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke baktheria e amehang ka moriana:

• Litho tsa ENT, pampitšana ea ho phefumoloha e kaholimo le e ka tlase: a hlobaetsang le lefu la sethoathoa, qoqotho ea qoqotho, pneumonia, bronchitis, abscess ea lung.
• Sistimi ea genitourinary: cystitis, endometritis, adnexitis, septic abortion, pyelitis, pyelonephritis, epididymitis, urethritis, prostatitis e sa foleng, jj.
• gastrointestinal pampiri: Enteritis ea baktheria (bakeng sa ts'oaetso e bakoang ke likokoana-hloko tsa anaerobic, hangata moriana o sebelisoa e le karolo ea kalafo e kopaneng),
• ducts tsa bile: cholecystitis, cholangitis,
• listeriosis, leptospirosis, lefu la Lyme (borreliosis),
• tšoaetso ea letlalo le lisele tse bonolo,
• endocarditis (ho kenyelletsa thibelo ea eona nakong ea mekhoa ea meno).

Hape, matlapa a Amoxicillin Sandoz a sebelisoa e le karolo ea phekolo e kopaneng (hammoho le clarithromycin, metronidazole kapa proton pump inhibitors) ho felisa Helicobacter pylori.

Contraindication

• bana ba ka tlase ho lilemo tse 3,
• hypersensitivity ho lithibela-mafu tse ling tsa beta-lactam, mohlala, cephalosporins kapa carbapenems (karabelo ea sefapano e ka hlaha),
• sefuba
• kutloisiso e eketsehileng ea karolo efe kapa efe ea lithethefatsi kapa penicillin.

Matlapa a Amoxicillin Sandoz a lokela ho sebelisoa ka hloko maemong a latelang:

• mathata a matla a tšilo ea lijo, a tsamaeang le letšollo / ho hlatsa ha nako e telele,
• mosebetsi o sa sebetseng oa renal,
• tšoaetso ea vaerase
• asthma ea lefu la bronchial,
• allergic diathesis
• mononucleosis e tšoaetsanoang (kotsi e eketsehang ea lekhopho la letlalo la erythematous),
• acute lymphoblastic leukemia,
• bana ba fetang lilemo tse 3,
• boimana (melemo ho mme e lokela ho feta likotsi bakeng sa lesea).

Ketso ea Pharmacodynamic

Mofumahali
Amoxicillin ke penicillin e entsoeng ka halofo e nang le phello ea bactericidal.
Mohato oa ketso ea bactericidal ea amoxicillin e amahanngoa le ho senya sebopeho sa lisele tsa baktheria sethaleng sa phatlalatso. Amoxicillin ka ho khetheha e thibela li-enzyme tsa lisele tsa baktheria tsa lisele (li-peptidoglycans), li fella ka hore ebe ke lefu la tsona le lefu.
E sebetsang khahlanong le:
Baktheria ea aerobic ea gram
Bacillus anthracis
Corynebacterium spp. (ntle le Corynebacterium jeikeium)
Enterococcus faecalis
Listeria monocytogene
Streptococcus spp. (ho kenyeletsa Streptococcus pneumoniae)
Staphylococcus spp. (ntle le penicillinase e hlahisang lits'oaetso).
Baktheria ea aerobic ea Gram-negative
Borrelia sp.
Escherichia coli
Haemophilus spp.
Helicobacter pylori
Leptospira spp.
Nisseria spp
Proteus mirabilis
Salmonella spp
Shigella spp.
Treponema spp.
Campylobacter
Tse ling
Chlamydia spp.
Libaktheria tsa Anaerobic
Bacteroides melaninogenicus
Clostridium spp.
Fusobacterium spp.
Peptostreptococcus spp.
Ha e sebetse khahlanong le:
Baktheria ea aerobic ea gram
Staphylococcus (Mechini e hlahisang β-lactamase)
Baktheria ea aerobic ea Gram-negative
Spinetobacter spp.
Tsena ea spopr.
Enterobacter spp.
Klebsiella spp.
Moraxella catarrhalis
Proteus spp
Providencia spp.
Pseudomonas spp.
Serratia spp
Libaktheria tsa Anaerobic
Bacteroides spp.
Tse ling
Mycoplasma spp.
Rickettsia spp.
Mofumahali
Bioavailability e felletseng ea amoxicillin e itšetlehile ka lethalamo ebile e tloha ho 75 ho isa ho 90%. Boteng ba lijo ha bo ame monko sethethefatsi. Ka lebaka la taolo ea molomo ea amoxicillin ka tekanyetso e le 'ngoe ea 500 mg, khatello ea lithethefatsi ho plasma ke 6 - 11 mg / L. Kamora ho tsamaisoa ka molomo, boholo ba mahloriso a plasma bo fihlella kamora lihora tse 1-2.
Pakeng tsa 15% le 25% ea amoxicillin e hokahana le liprotheine tsa plasma.
Ka potlako moriana o kenella ka har'a lithane tsa matšoafo, secretion ea bronchial, fluid fluid e bohareng, bile le mkojo. Ha ho e-na le ho ruruha ha meninges, amoxicillin e kenella ka har'a mokelikeli oa "cerebrospinal" ka bongata.
Ka ho ruruha ha meninges, khatello ea moriana o ka har'a mokelikeli oa "cerebrospinal fluid" e ka ba karolo ea mashome a mabeli lekholong ea khatello ea mali maling a mali. Amoxicillin e tšela placenta mme e fumanoa ka bongata lebeseng la matsoele.
Ho fihla ho 25% ea lethal dose e laetsoeng metabolized ka ho thehoa ha penicilloic acid e sa sebetseng.
Hoo e ka bang 60-80% Amoxicillin e hlahella e sa fetoloe ke liphio nakong ea lihora tse 6 ho isa ho tse 8 kamora ho sebelisa moriana.
Tekanyo e nyane ea lithethefatsi e qheletsoe kahare.
Bophelo ba halofo ke lihora tse 1-1,5. Ho bakuli ba nang le bothata ba ho se sebetse hantle ha methapo e sa pheleng, halofo ea bona ea bophelo e fapana ho tloha lihora tse 5 ho isa ho tse 20. Lithethefatsi li hlahisoa ke hemodialysis.

Amoxicillin e bontšoa bakeng sa mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke libaktheria tse seng khahlanong le lithethefatsi:
• mafu a tšoaetsanoang a "lipilisi tsa" phepelo e phahameng le e tlase ea ho hema le litho tsa ENT (tonsillitis, media anditis acitis, pharyngitis, bronchitis, pneumonia, abscess ea lung),
• mafu a tšoaetsanoang a "genitourinary system" (urethritis, pyelonephritis, pyelitis, bacteratitis e sa foleng, cyidymitis, cystitis, adnexitis, ho ntša mpa ka septic, endometritis, jj)
• mafu a ka mpeng: bacteric Enteritis. Phekolo ea ho kopanya e ka hlokahala bakeng sa tšoaetso e bakoang ke likokoana-hloko tsa anaerobic,
• mafu a tšoaetsanoang le a tšoaetsanoang a leseli la biliary (cholangitis, cholecystitis),
• ho felisoa Helicobacter pylori (hammoho le proton pump inhibitors, clarithromycin kapa metronidazole),
• tšoaetso ea letlalo le lisele tse bonolo,
• leptospirosis, listeriosis, lefu la Lyme (borreliosis),
• endocarditis (ho kenyelletsa thibelo ea endocarditis nakong ea ts'ebetso ea meno).

Sebelisa nakong ea bokhachane le pelehi

Boithuto ba liphoofolo bo bontšitse hore amoxicillin ha e na phello ea embryotoxic, teratogenic le mutagenic ho fetus. Leha ho le joalo, lithuto tse lekaneng le tse laoloang hantle mabapi le tšebeliso ea amoxicillin ho basali ba baimana ha li e-so ka li etsoa, ​​ka hona, ts'ebeliso ea amoxicillin nakong ea kemolo e ka etsahala feela haeba molemo o reriloeng ho mme o feta kotsi e ka bang teng ho lesea. Setlhare sena se qhekelloa ka lebese la matsoele, ka hona, ha u alafa ka amoxicillin nakong ea lebese, ho hlokahala hore ho rarolloe bothata ba ho emisa ho anyesa, hobane lets'ollo le / kapa fungal colonization ea mucous membrane e ka ba teng, hammoho le ho susumetsa lithibela-mafu tsa beta-lactam ho lesea le anyesang.

Tekanyetso le tsamaiso

Ka hare.
Phekolo ea tšoaetso:
Joaloka molao, kalafo e khothalletsoa ho tsoela pele matsatsi a 2-3 kamora ho nyamela ha matšoao a lefu lena. Maemong a tšoaetso e bakoang ke β-hemolytic streptococcus, ho felisoa ha pathogen ka botlalo ho hloka kalafo bonyane matsatsi a 10.
Phekolo ea botsoali e bontšoa bakeng sa monyetla oa tsamaiso ea molomo le kalafo ea tšoaetso e mpe.
Litlhare tsa batho ba baholo (ho kenyeletsa bakuli ba tsofetseng):
Tekanyetso e tloaelehileng:
Tekanyetso e tloaelehileng e tsoa ho 750 mg ho isa ho 3 g ea amoxicillin ka letsatsi ka tekanyetso e 'maloa. Maemong a mang, ho khothalletsoa ho fokotsa tekanyetso ho 1500 mg ka letsatsi ho litekanyetso tse 'maloa.
Nako e khutšoanyane ea kalafo:
Ts'oaetso e sa sebetseng ea moroto: Ho nka 2 g ea moriana ka makhetlo a mabeli bakeng sa ente e 'ngoe le e' ngoe e nang le karohano pakeng tsa tekanyetso ea lihora tse 10-12.
Litekanyetso tsa bana (ho fihlela lilemo tse 12):
Sekhahla sa letsatsi le letsatsi bakeng sa bana ke 25-50 mg / kg / letsatsi ka tekanyetso e 'maloa (boholo ba 60 mg / kg / letsatsi), ho latela pontšo le ho teba ha lefu lena.
Bana ba boima bo fetang lik'hilograma tse 40 ba lokela ho fumana litekanyetso tsa batho ba baholo.
Tekanyetso ea ho hloleha ha liphio:
Bakeng sa bakuli ba nang le bothata bo matla ba ho phekola renal, lethal dose le lokela ho fokotsoa. Ka tumello ea ho ba le fig ka tlase ho 30 ml / min, ho eketsoa keketseho lipakeng tsa litekanyetso kapa ho fokotseha ha tekanyetso e latelang. Ka ho se sebetse hantle hantle, lithuto tse khutšoane tsa 3 g lia qhekelloa.

Batho ba baholo (ho kenyeletsa bakuli ba tsofetseng):

A amehile ka ho renal mosebetsi ho bana ba boima ba ka tlase ho 40 kg

Thibelo ea Endocarditis
Bakeng sa thibelo ea endocarditis ho bakuli ba sa sebetsanang le ho hlobaela ka kakaretso, 3 g ea amoxicillin e lokela ho fuoa hora e le 'ngoe pele ho buoa,' me haeba ho hlokahala, e ngoe 3 g kamora lihora tse 6.
Bana ba khothalletsoa ho fana ka amoxicillin ka tekanyo ea 50 mg / kg.
Bakeng sa tlhaiso-leseling e batsi le litlhaloso tsa mekhahlelo ea bakuli ba kotsing ea endocarditis, lebisa ho litataiso tsa semmuso tsa lehae.

Litla-morao

Liketsahalo tsa litla-morao li hlalositsoe ho latela gradation e latelang: khafetsa - ho feta 10%, khafetsa - ho tloha ho 1 ho isa ho 10%, infrequent - ho tloha 0,1% ho isa ho 1%, ka seoelo - ho tloha 0,01 ho isa ho 0.1%, haholo ka seoelo - ka tlase ho 0,01%.
Ho tsoa ho tsamaiso ea pelo le pelo:khafetsa: tachycardia, phlebitis, ka seoelo: ho theola khatello ea mali, ka seoelo: Phetiso ea nako ea QT.
Karolong ea mali le tsamaiso ea methapo ea kutlo:khafetsa: eosinophilia, leukopenia, bonyane: neutropenia, thrombocytopenia, agranulocytosis, ka seoelo: anemia (ho kenyelletsa hemolytic), thrombocytopenic purpura, pancytopenia.
Ho tsoa tsamaisong ea methapo:khafetsa: ho otsela, hlooho ea hlooho, ho tsekela, bonyane: ho tšoha, ho ruruha, ho tšoenyeha, ataxia, phetoho ea boits'oaro, ho ruruha ha maikutlo, ho tšoenyeha, ho tšoenyeha ka boroko, khatello ea maikutlo, ho opeloa ke thipa, ho thothomela, pherekano, ho tsitsipana, ka seoelo: hypersthesia, pono e sa sebetseng, monko le maikutlo a thetsang, lipono.
Ho tsoa ts'ebetsong ea genitourinary:bonyane: interstitial nephritis, eketseha serum creatinine mahloriso.
Ho tsoa pampiring ea mala le sebete: dysbiosis, phetoho ea tatso, stomatitis, glossitis, khafetsa: ho nyekeloa ke pelo, letšollo, ho eketseha hoa lintho tse amanang le lefu la hepatic (ALT, AST, alkaline phosphatase, γ-glutamyltransferase), keketseho ea bongata ba bilirubin serum ea mali. bonyane: ho hlatsa, dyspepsia, bohloko ba epigastric, hepatitis, choleundatic jaundice, ka seoelo: ho hloleha ha sebete haholo, lets'ollo le motsoako oa mali, pseudomembranous colitis, ponahalo ea 'mala o motšo oa leleme.
Ho tsoa ts'ebetsong ea musculoskeletal:bonyane: arthralgia, myalgia, maloetse a tendon ho kenyeletsa tendonitis, ka seoelo: Ho phatloha ha tendon (ho ka khonehang ka makhetlo a mabeli le lihora tse 48 kamora ho qala kalafo), bofokoli ba mesifa, rhabdomyolysis.
Ka lehlakoreng la letlalo:khafetsa: pruritus, rash, bonyane: urticaria ka seoelo: photosensitization, ho ruruha ha letlalo le lera la mucous, erythema e kotsi (Stevens-Johnson syndrome), chefo e ka fokotsang lefu lena (Lyell syndrome).
Ho tsoa tsamaisong ea endocrine:bonyane: anorexia ka seoelo: hypoglycemia, haholo-holo ho bakuli ba nang le lefu la tsoekere.
Ho tsoa ts'ebetsong ea phefumoloho:bonyane: bronchospasm, dyspnoea, ka seoelo: allergic pneumonitis.
Kakaretso:bonyane: bofokoli bo akaretsang ka seoelo: feberu.
Tse ling: ho hema hanyane, phepelo ea botšehali, bonyane: bonohe (haholoholo ho bakuli ba nang le mafu a sa foleng kapa ho fokotsoa ha matla a mmele), karabelo tse ts'oanang le lefu la serum, linyeoe tse ikemetseng: anaphylactic makala.

Bongata

Matšoao: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho leka-lekana ha motlakase oa motlakase, nephrotoxicity, crystalloria, ho ts'oaroa ha sethoathoa.
Phekolo: Tšebeliso ea merafo e kenngoeng ka matla, kalafo ea matšoao, khalemelo ea ho se leka-lekane ha metsi, hemodialysis e ka etsahala.

Ho sebelisana le lithethefatsi tse ling

Nako e ka eketsoang ea ho monya digoxin nakong ea phekolo Amoxicillin Sandoz ®.
Propenecid e fokotsa tlhahiso ea amoxicillin ke liphio mme e eketsa bongata ba amoxicillin ka bile le mali.
Ts'ebeliso e le 'ngoe ea amoxicillin le tse ling lithethefatsi tsa bacteriostatic (macrolides, tetracyclines, sulfonamides, chloramphenicol) ka lebaka la monyetla oa ho hanyetsa. Ka ts'ebeliso e tšoanang aminoglycosides mme amoxicillin e ka ba le phello ea synergistic.
Ts'ebeliso e le 'ngoe ea amoxicillin le disulfiram.
Ka ts'ebeliso e tšoanang methotrexate le amoxicillin, keketseho ea chefo ea pele e ka etsahala, mohlomong ka lebaka la phapanyetsano ea thibelo ea sechu ea secretion ea methotrexate ke amoxicillin.
Li-antacid, glucosamine, litlolo, lijo, aminoglycosides fokotsa lebelo mme o fokotse ho amoheloa, asiti ea ascorbic e eketsa ho kenngoa ha amoxicillin.
E eketsa ts'ebetso ea ho se tsamaisane anticoagulants (hatella microflora ea ka mpeng, e fokotsa mofuta oa vithamine K le index ea prothrombin), e fokotsa katleho estrogen e nang le lithibela-pelehi tsa molomo, lithethefatsi tse metabolite para-aminobenzoic acid (PABA), ethinyl estradiol - kotsi ea "phallo" ea mali.
Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, lithethefatsi tse seng khahlanong le ts'oaetso tsa mafu le lithethefatsi tse ling tse thibelang secretion ea tubular, eketsa mokokotlo oa amoxicillin maling.
Allopurinol e eketsa kotsi ea ho ba le lekhopho la letlalo.

Litaelo tse khethehileng

Pele o fana ka Amoxicillin Sandoz ®, o lokela ho etsa bonnete ba hore likokoana-hloko tsa likokoana-hloko tse bakang lefu lena le tšoaetsanoang li ela hloko moriana.
Ts'ebetsong e matla ea ts'oaetso le ea ho ruruha ea sefuba sa ka mpeng, e tsamaeang le lets'ollo le nako e telele, ha ho khothaletsoe ho nka Amoxicillin Sandoz ® kahare ka lebaka la moriana o ka tlase o ka fumanehang.
Ha o phekola lets'ollo le bonolo ka mokhoa oa kalafo, ho ka qojoa meriana e thibelang lefu la sethoathoa, 'me ho ka sebelisoa litlhare tsa kaolin kapa tse fumanehang ka har'a antidiarrheal. Bakeng sa letšollo le matla, etela ngaka.
Ka nts'etsopele ea letšollo le sa khaotseng le ho phehella, nts'etsopele ea pseudomembranous colitis (e bakoang ke Clostridium Hardile). Tabeng ena, Amoxicillin Sandoz ® e lokela ho khaotsa mme kalafo e nepahetseng e lokela ho fanoa. Ka nako e ts'oanang, lithethefatsi tse fokotsang motility oa mpa ea gastrointestinal lia hanyetsoa.
Ka mokhoa oa kalafo, hoa hlokahala ho lekola boemo ba ts'ebetso ea mali, sebete le liphio.
Hoa khoneha ho hlaolela superinitness ka lebaka la kholo ea microflora ha e na taba le eona, e hlokang phetoho e lekanang ea kalafo ea lithibela-mafu.
Ho bakuli ba nang le hypersensitivity ho penicillin, ho kopana le lintho tse ling tse sebetsanang le lithibela-mafu tse ling tsa beta-lactam hoa khoneha.
Phekolo e hlile e tsoela pele lihora tse ling tse 48-72 kamora ho nyamela hoa matšoao a bongaka a lefu lena.
Ka tšebeliso e ts'oanang ea lithibela-mafu tsa molomo tse nang le estrogen le amoxicillin, mekhoa e meng kapa e eketsehileng ea thibelo ea bokhachane e lokela ho sebelisoa haeba ho khonahala.
Amoxicillin Sandoz ® ha e khothalletsoe kalafo ea mafu a tšoaetsanoang a vaerase a tšoaetsanoang ka lebaka la ts'ebetso ea eona e tlase.
Ho hlokoa hloko haholo-holo ho bakuli ba nang le allergic diathesis kapa lefu la bronchial asthma, e leng nalane ea mafu a ka mpeng (haholo-holo colitis e bakoang ke kalafo ea lithibela-mafu).
Ka tšebeliso ea nako e telele ea Amoxicillin Sandoz ®, nystatin, levorin, kapa lithethefatsi tse ling tsa antifungal li lokela ho beoa ka nako e le ngoe.
Nakong ea kalafo, ethanol ha e khothalletsoe.
Ts'ebeliso ea Amoxicillin Sandoz ® ha e ame litholoana tsa tlhahlobo ea enzymatic ea glucosuria, leha ho le joalo, liphetho tsa urinalysis tsa 'nete tsa tsoekere e ka khona.
Ha u ntse u nka Amoxicillin Sandoz ®, ho kgothaletswa hore o noe metsi a mangata ho thibela sebopeho sa kristale ea amoxicillin ka har'a moroto.

Tšusumetso ho bokhoni ba ho khanna makoloi le ho etsa lintho tse ling tse hlokang ho tsepamisa mohopolo le lebelo la maikutlo a psychomotor

Ka lebaka la menyetla ea litla-morao, joalo ka ho otsela, ho tšoaroa ke hlooho le pherekano, tlhokomeliso e lokela ho ba teng ha u etsa lintho tse ka bang kotsi tse hlokang ho tsepamisa mohopolo le ho potlaka haholo ka karabelo ea psychomotor.

Sebopeho sa matlapa a Amoxicillin

Motsoako oa litlhare o hlahisoa ka litekanyetso ho tloha ho 125 mg ho isa ho gram e le ngoe. Karolo e sebetsang ea sethethefatsi ke ntho e nang le lebitso le le leng - amoxicillin ka sebopeho sa amohelang bophelo. Joalo ka ha ho sebelisoa likarolo tse thusang:

• magnesium stearate,
• talcum phofo
• litapole tsa litapole.

Li-capsules tsa kahare le tsona li na le likarolo tsa shell-ente-soluble.

Motsoako ke oa litlhare tse thibelang likokoana-hloko tsa penisilini. E ea sebetsa khahlano le libaktheria tse ntle tsa gram le gram, hammoho le lithutsoana tse mpe tsa gram. Karolo e sebetsang e kenya letsoho ho sitiseng sebopeho sa lisele tsa cell, ka ho etsa joalo e emisa keketseho ea likolone tsa likokoana-hloko tsa pathogenic.

Litaelo tsa matlapa a sebelisang Amoxicillin 250 mg

Lithethefatsi Amoxicillin 0,25 g e fuoe bana le batho ba baholo ba nang le 'mele o fokolang oa thuto bakeng sa bonyane matsatsi a 5. Nako e telele ea ts'ebeliso ke libeke tse peli.

Hoa hlokahala hore u noe meriana lihora tse ling le tse ling tse 8 pele u ja:

• Matlapa a - - lilemo tse 2,
• Letlapa lohle - ho tloha lilemong tse 5,
• Matlapa a 1-2 - ho tloha ho lilemo tse 10 le ho feta.

Matšoao a sebelisoang ke marang-rang a likokoana-hloko tsa moea o kaholimo le o ka tlase oa phefumoloho:

• bronchitis
• tracheitis
• pharyngitis
• tonsillitis
• sinusitis
• sinusitis
• sepsis
• hammoho le tšoaetso ea letlalo le sebopeho sa purulent letlalong.

Litaelo tsa ho sebelisoa ha litafole Amoxicillin 500 mg

Lithethefatsi Amoxicillin 0.5 g e etselitsoe batho ba baholo le bana ba ka holimo ho lilemo tse 10. Ho bohlokoa hore boima ba 'mele bo ka holimo ho 40 kg. Nako ea kalafo e khethoa ka bonngoe mme hangata ke matsatsi a 7-10.

Ka tšebeliso ea nako e telele ea lithethefatsi, hammoho le moriana o thibelang likokoana-hloko, ho khothalletsoa ho sebelisa lithethefatsi tse thibelang mahlo.

Ho thibetsoe ka thata ho feta tekanyo ea tumello e lumelloang, kaha sena se ka tsosa karabelo e mpe.

Litaelo tsa ho sebelisoa ha litafole Amoxicillin 875 + 125

Bakeng sa mafu a mang, ho hlokahala li-capsules tsa Amoxicillin tse nang le litekanyetso tsa 875 + 125. Linomoro tsena li bolela hore tekong e le 'ngoe ea moriana ho na le 875 mg ea ntho e thibelang likokoana-hloko le 125 mg ea motsoako o hatellang ho hanyetsa ha likokoana-hloko. Ka tloaelo, clavulanic acid e sebetsa e le thibelo. Ka lebaka leo, libaktheria tsa penicillinase-secretinging li ke ke tsa khona ho mamella moemeli oa likokoana-hloko kamoo li neng li ka khona ntle le thibelo.

Moriana o fuoe mafu a itekanetseng le a matla:

• tsamaiso ea ho phefumoloha
• lisele tsa mesifa ea lisele,
• ts'ebetso ea ho ruruha ea tsamaiso ea moroto le litho tsa botona.

Bana ba lilemo li 12 ho isa ho batho ba baholo ba behiloe 1 capsule (875 + 125) ka kamohelo e le ngoe. Nka makhetlo a mabeli nakong ea letsatsi. Nako ea kalafo ke matsatsi a 5-14.

Litaelo tsa matlapa a sebelisang Amoxicillin 1000 mg

Ngoliso ea amoxicillin e thibelang likokoana-hloko e fanoa ka tekanyetso ea gram e le 'ngoe bakeng sa bakuli ba nang le mafu a matla a amanang le tsamaiso ea phefumoloho. Moriana o ka sebelisoa ho bana bao boima ba 'mele ba bona bo fetang ka kilo tse 40, le ho batho ba baholo:

• tekanyetso e le 1 ea capsule,
• nka makhetlo a mabeli ka letsatsi kamora nako e lekanang,
• Nako ea ts'ebeliso ke libeke tse 1-2.

Ka feberu ea typhoid, lithibela-mafu tse ka bang 1.5-2 g li sebelisoa makhetlo a 3 ka letsatsi. Kamora ho kula, ka moo matšoao a lefu a felang, kalafo e tsoela pele matsatsi a mang a 2-3.

Matlapa a 3 a Amoxicillin - litaelo tsa tšebeliso

Bakeng sa kalafo ea gonorrhea, e tsoang ka mokhoa o sa rarahanang oa ho hlobaela, moemeli oa antimicrobial o beoa ka tekanyetso ea ligrame tse tharo. Ena ke eona feela boemo ha ho fanoa ka lethal e le leholo la kokoana-hloko bakeng sa tekanyetso e le 'ngoe.

Bakeng sa kalafo ea gonorrhea e sebelisitsoeng:

• ho banna, li-capsules tse 3 tsa 1000 mg hang,
• ho basali, 3 g ea lithethefatsi ka matsatsi a mabeli.

Ka maikutlo a ngaka, Amoxicillin e thibelang likokoana-hloko e kopantsoe le sehanyetsi se thehiloeng ho probenecid:

• Pele u nka moriana o thibelang likokoana-hloko u hloka ho noa motsoako oa gout,
• Kamora halofo ea hora, nka matlapa a 3 a Amoxicillin le litekanyetso tsa 1 g.

Litaelo tsa ho sebelisoa ha matlapa a Amoxicillin ho batho ba baholo

Bakeng sa bakuli ba baholo, moriana o laetsoe kalafo ea tšoaetso le mafu a tšoaetsanoang:

• tšilo ea lijo
• tsamaiso ea methapo
• liphatsa tsa lefutso
• sistimi e tlase ea ho hema,
• nasopharynx
• Litho tsa ENT.

Tšebeliso ea makhetlo a mangata makhetlo a mabeli ka letsatsi. Tekanyetso e beoa ka bomong ho tloha ho 250 ho isa ho 1000 mg. Matšoao:

• otitis media: sethala se bobebe - makhetlo a 500 mg makhetlo a 3 ka letsatsi, le ho ruruha ho matla - makhetlo a 875 mg makhetlo a 3 ka letsatsi ka lihora tse 8 ka matsatsi a 5,
• sinusitis: 1500 mg e arotsoe ka litekanyetso tse 3 nako le nako bakeng sa matsatsi a 7,
• rhinopharyngitis: 500 mg makhetlo a mararo ka letsatsi, nako ea kalafo ke matsatsi a 7-14,
• tracheitis: 0.5 g makhetlo a 3 ka letsatsi, le lefu le matla - 1 g makhetlo a mararo ka letsatsi,
• bronchitis: nka capsule e le 'ngoe (500 mg) makhetlo a 3 ka letsatsi ka mor'a lihora tse 8,
• pyelonephritis: 500 mg makhetlo a 3 ka letsatsi, maemong a matla - 1000 mg makhetlo a mararo ka letsatsi, nako ea kalafo ke matsatsi a 7- 7,
• cystitis: 250-500 mg e arotsoe ka litekanyetso tse tharo, ka lefu le tsoetseng pele - 1 g makhetlo a 3 ka letsatsi.

Amoxicillin 250 - litaelo tsa tšebeliso ea matlapa a batho ba baholo

Li-capsules tsa Amoxicillin tse nang le litekanyetso tsa 250 mg li fuoe batho ba baholo ba nang le:

• mafu a sa tsamaeeng le mathata,
• bonolo kapa bo itekanetseng ba thupelo ntle le tebello ea ho senyeha.

Litlhahiso tsa ho amoheloa:

• moriana o nooa matlapa a 1-2 ka nako pele ho lijo,
• khafetsa ea tšebeliso makhetlo a 3 ka letsatsi,
• karohano lipakeng tsa tekanyetso ke lihora tse 8.

Amoxicillin 500 - litaelo tsa tšebeliso ea matlapa a batho ba baholo

Ka tekanyo ea 500 mg, ho thibeloa lithibela-mafu bakeng sa bakuli ba baholo haeba lefu le sa rarahana mme le hlaha ka mokhoa o itekanetseng:

• Letlapa le le leng ka nako
• motšehare, litekanyetso tse 3 li nkuoa kamora nako e lekanang,
• nako ea tsamaiso ke matsatsi a 5-14.

Ha ho nka matsatsi a fetang 10, ho hlokahala hore ho hlahlojoe ts'ebetso ea sebete le a liphio.

Matlapa a Amoxicillin a 1000 - litaelo tsa ho sebelisoa ke batho ba baholo

Ho khethoa ha li-antibiotic tse 1000 mg bakeng sa kalafo ho batho ba baholo ho laetsoe mefuta e matla le e leka-lekaneng:

• otitis
• puruse tonillitis,
• pharyngitis e hlobaetsang
• pyelonephritis,
• cystitis
• mafu a tšoaetsanoang ka ho kopanela liphate
• tšoaetso ea letlalo la puroma.

• Letlapa le le leng ka tekanyetso
• khafetsa tšebeliso makhetlo a mabeli ka letsatsi,
• karohano pakeng tsa tekanyetso e lokela ho ba hantle lihora tse 12,
• Nako ea kalafo ke matsatsi a 5-10.

Tekanyetso e phahameng ea lithethefatsi e ka ama ts'ebetso ea sebete le liphio; ho khothaletsoa ho shebella ts'ebetso ea bona ea ts'ebetso ea bona.

Litaelo tsa ho sebelisa litafole tsa Amoxicillin bakeng sa bana

Amoxicillin bakeng sa bana ke moemeli oa antibacterial oa sehlopha sa penicillin. Ho bana ba banyenyane, moriana o ka baka karabelo ea hypersensitivity, ka hona, e fanoe ka temoso le tlasa taolo ea ngaka.

Tekanyetso ea Amoxicillin ea bana e behiloe ka bonngoe:

• masea le bana ba selemo sa pele sa bophelo ho latela lilemo tse 20-25 mg ka kilogramu,
• ho tloha ho lilemo tse 2 ho isa ho 125 mg,
• ho tloha ho lilemo tse 5 ho isa ho 250 mg,
• ho tloha ho lilemo tse 10 ho isa ho 500 mg.

Ho ipapisitsoe le anamnesis le data e rekotiloeng, bana ba fuoa tekanyetso e tloaelehileng ea 125-500 mg bakeng sa ts'ebeliso e le 'ngoe. Khafetsa ea tšebeliso ke 2-3, 'me nako ke matsatsi a 5-7. Ho khothalletsoa ho fana ka moriana qalong ea lijo. Sena se tla fokotsa menyetla ea ho sisinyeha ka mpeng ho atisang ho hlaha ho bana ha ho sebelisoa antimicrobial.

• mecha ea litaba ea otitis le otitis,
• pharyngitis le rhinopharyngitis,
• bronchitis
• tonsillitis le adenoiditis,
• cystitis le pyelonephritis,
• tšoaetso ea puroma ea lisele tse bonolo.

Matlapa a 250 a Amoxicillin - litaelo bakeng sa bana

Ho lumelletsoe ho sebelisa lithethefatsi ka litekanyetso tsa 250 mg ho bana ba tsoang lilemo tse peli.

Tekanyetso ena e lumella tšebeliso ea moriana ka tsela ea likhabapo. Haeba ngoana a sa khone ho e metha, o ka bula khetla, e tšollela phofo ho eona ebe o qhibiliha ka 5-10 ml ea metsi.

Litaelo tsa ho sebelisa matlapa a Amoxicillin bakeng sa basali baimana

Ho latela tlhaiso-leseling e tsoang ho litaelo tsa tšebeliso, moriana o ka laeloa ho bo-mme ba lebelletsoeng haeba ho na le matšoao a ho sebelisoa:

• gonorrhea
• urethritis
• cystitis
• pyelonephritis,
• tšoaetso e phahameng ea phepelo ea methapo ea kutlo e nang le lipontšo tsa catarrhal ka mokhoa oa khohlela, nko e phallang,
• bronchitis
• tracheitis.

Boithuto bo bontšitse hore lithibela-mafu ha li bake liphetoho ebile ha li khone ho senya tsoelo-pele ea embryonic.

Nakong ea kemolo, tekanyetso e tlase e sebetsang ea lithethefatsi e laetsoe - ho tloha 250 mg makhetlo a mararo ka letsatsi. Nako e fokolang ea ts'ebeliso ke matsatsi a 5-7. Leha ho le joalo, ngaka e ka fetola mekhoa le mekhoa ea kalafo ho latela mofuta oa lefu lena.

Amoxicillin - analogues - litaelo tsa tšebeliso

Ho ipapisitsoe le ntho e sebetsang, lithibela-mafu tse thibelang likokoana-hloko lia fumaneha. Matšoao a sebelisoang le tsona a a fetoha. Litaelong tsa ho sebelisa meriana e meng ho na le ho se lumellane ho regimen le contraindication.

Flemoxin Solutab

E sebelisoa ka mafolofolo ho bana, hobane matlapa a qhibilihang habonolo ka metsing. E fumaneha ka litekanyetso tsa 125, 250, 500 le 1000 mg. Amoxicillin, cellulose e jalang, litatso le linyatso li teng.

Ho se sebetse hantle ka molao ho tlatsetsa lethathamong le tloaelehileng la liphatlalatso. Setlhare sena se sebelisoa ho bana ho tloha tsoalong, 'me lethalamo le baloa ka boima ba' mele:

• likhoeling tse 12 tse qalang, 30-60 mg ka letsatsi,
• ho tloha ho lilemo tse 3 ho isa ho 375 mg habeli,
• ho tloha ho lilemo tse 10 750 mg habeli kapa 500 makhetlo a mararo.

Theko Flemoxin Solutab:

• 125 mg - 230 rub.,
• 500 le 250 mg - li-ruble tse 260.,
• 1000 mg - 450 li-ruble.

Setlhare se fumaneha ka tekanyetso ea 250, 500 le 1000 mg. Lithethefatsi li loants'itsoe:

• lefu la sethoathoa
• allergic diathesis
• hay fever
• tšoaetso ea mononucleosis,
• tšoaetso ea vaerase ea ho hema
• mafu a ka mpeng, ao ho hlatsoang, lets'oao le a lemohang.

Ospamox e nkuoa ka molomo kaofela, e hlatsuoa ka metsi. Setlhare se sebelisoa mefuteng e latelang:

• ho bana ba ka tlase ho lilemo tse 10 ka mokhoa oa ho emisoa, matlapa ha a beoa,
• ho tloha lilemo tse 10 ho isa ho 0.5 g hoseng le mantsiboea,
• ho tloha ho lilemo tse 16 ho isa ho 750 mg habeli,
• ho batho ba baholo, 1 g hoseng le mantsiboea.

Theko ea lithethefatsi ka litekanyetso tse fapaneng e maemong a fapaneng ho tloha ho li-ruble tse 30 ho isa ho tse 150.

E fumaneha ka tekanyetso ea 250 le 500 mg, ho khothalletsoa kalafo ea tšoaetso ea baktheria ho latela morero o le mong:

• 125 mg - kamora lilemo tse 2,
• 250 mg - kamora lilemo tse 5,
• 250-500 mg - kamora lilemo tse 10,
• bakeng sa batho ba baholo le ba lilemong tsa bocha ba lilemo li 18, 500 mg makhetlo a mararo kapa 1000 mg habeli.

Ha e ngoletsoe basali baimana.

Litsenyehelo tsa moriana ke li-ruble tse 30. bakeng sa li-250 mg le li-ruble tse 60. bakeng sa 500 mg.

Ntle le ntho ea mantlha e sebetsang ka bongata ba 250 le 500 mg, e na le lactulose, povidone, starch ea litapole, talc. Ha e ngoletsoe bana ba ka tlase ho lilemo tse 3. E khothalletsoa hore e sebelisoe:

• bakeng sa batho ba baholo 500-1000 mg,
• bakeng sa bacha 500-750 mg,
• bana ba lilemo li 3 ho isa ho tse 125-250 mg.

• 250 mg - li-ruble tse 60.,
• 500 mg - li-ruble tse 130.

Theko ea matlapa a Amoxicillin

Ho latela tekanyetso, palo ea litafole le moetsi, litšenyehelo tsa amoxicillin ea lithibela-mafu li fetoha:

• Hemofarm 16 likotoana tsa 500 mg - li-ruble tse 90.,
• Li-capsule tse 16 tsa Hemofarm tsa 250 mg - li-ruble tse 58.,
• Sandoz 12 likotoana tsa 1000 mg - li-ruble tse 165,
• Avva Rus matlapa a 20 a 500 mg - 85 li-ruble.

Litsenyehelo tsa lithethefatsi 500 mg li fapana ka litlhare tse fapaneng tsa marang-rang:

Mokhoa oa ho sebelisa: litekanyetso le kalafo

E etselitsoe tsamaiso ea molomo.

Joaloka molao, kalafo e khothalletsoa ho tsoela pele matsatsi a 2-3 kamora ho nyamela ha matšoao a lefu lena. Maemong a tšoaetso e bakoang ke D-hemolytic streptococcus, ho felisoa ha pathogen ka botlalo ho hloka kalafo bonyane matsatsi a 10.

Phekolo ea botsoali e bontšoa bakeng sa monyetla oa tsamaiso ea molomo le kalafo ea tšoaetso e mpe.

Litlhare tsa batho ba baholo (ho kenyeletsa bakuli ba tsofetseng):

Tekanyetso e tloaelehileng e tsoa ho 750 mg ho isa ho 3 g ea moriana ka letsatsi ho litekanyetso tse 'maloa. Maemong a mang, ho khothalletsoa ho fokotsa tekanyetso ho 1500 mg ka letsatsi ho litekanyetso tse 'maloa.

Nako e khutšoanyane ea kalafo:

Ts'oaetso e sa sebetseng ea moroto: Ho nka 2 g ea moriana ka makhetlo a mabeli bakeng sa ente e 'ngoe le e' ngoe e nang le karohano pakeng tsa tekanyetso ea lihora tse 10-12.

Litekanyetso tsa bana (ho fihlela lilemo tse 12):

Sekhahla sa letsatsi le letsatsi bakeng sa bana ke 25-50 mg / kg / letsatsi ka tekanyetso e 'maloa (boholo ba 60 mg / kg / letsatsi), ho latela pontšo le ho teba ha lefu lena.

Bana ba boima bo fetang lik'hilograma tse 40 ba lokela ho fumana litekanyetso tsa batho ba baholo.

Tekanyetso ea ho hloleha ha liphio:

Bakeng sa bakuli ba nang le bothata bo matla ba ho phekola renal, lethal dose le lokela ho fokotsoa. Ka tumello ea ho ba le fig ka tlase ho 30 ml / min, ho eketsoa keketseho lipakeng tsa litekanyetso kapa ho fokotseha ha tekanyetso e latelang. Ka ho se sebetse hantle hantle, lithuto tse khutšoane tsa 3 g lia qhekelloa.

Batho ba baholo (ho kenyeletsa bakuli ba tsofetseng):

Tlhahiso ea Creatinine> 30 di ml / min - ha ho hlokahale phetoho ea tekanyetso

Tlhahiso ea 'nete ea "ininine "10-30 ml / min - 500 mg ka lihora tse 12,

Tlhahiso ea Creatinine 30 di ml / min - ha ho hlokahale phetoho ea tekanyetso

Tlhahiso ea 'nete ea "ininine "10-30 ml / min - 15 mg / kg ka lihora tse 12,