Diabeteson MV 30 - litaelo tsa semmuso bakeng sa tšebeliso

E 'ngoe ea maemo a bohlokoa ka ho fetisisa bakeng sa kalafo e atlehileng ea lefu la tsoekere ke ho tsitsa ha maemo a tsoekere. Ka hona, ha u reka moemeli oa hypoglycemic Diabeteson MV 30 mg, litaelo tsa tšebeliso li lokela ho ithutoa ka hloko ho loants'oa lefu lena ka katleho.

Ho ba setho sa sehlopha sa bobeli sa sulfonylurea, sethethefatsi se fokotsa tsoekere ea mali mme se tlosa matšoao a lefu la tsoekere le sa ts'epeng insulin.

Lipalo-palo tse nyahamisang li bontša hore menyetla ea lefu lena e ntse e eketseha selemo se seng le se seng. Ho na le mabaka a mangata a susumetsang sena, empa har'a bona, liphatsa tsa lefutso le bophelo ba ho lula fatše li hloka tlhokomelo e khethehileng.

Lithethefatsi Diabeteson MV 30 mg ha e lekanye feela boemo ba glycemia, empa hape e thibela nts'etsopele ea mathata a mangata a lefu la tsoekere, mohlala, retinopathy, nephropathy, neuropathy le ba bang. Ntho ea bohlokoa ke ho tseba ho nka sethethefatsi sena ka nepo, se tla tšohloa sehloohong sena.

Tlhahisoleseling ka kakaretso ea lithethefatsi

Diabeteson MV 30 ke setlhare se tsebahalang se lokollotsoeng sa hypoglycemic lefats'eng ka bophara. E hlahisoa ke k'hamphani ea meriana ea Mafora e bitsoang Les Laboratoires Serviceier Іndustrie.

Moemeli oa hypoglycemic o sebelisetsoa lefu la tsoekere le sa itšetleheng ka insulin, ha boikoetliso ba 'mele le ho ja lijo tse nang le phepo li ke ke tsa fokotsa tsoekere ea mali. Ntle le moo, e 'ngoe ea matšoao a ts'ebeliso ea lithethefatsi ke thibelo ea mathata a kang microvascular (retinopathy le / kapa nephropathy) le lefu la macrovascular (stroke kapa infarction ea myocardial).

Motsoako o ka sehloohong oa sethethefatsi ke gliclazide - e tsoang ho sulfonylurea. Kamora ho tsamaisoa ka molomo, motsoako ona o kenella ka botlalo ka mpeng. Likahare tsa eona li eketseha butle butle, 'me boemo bo holimo bo fihlella ka nako ea lihora tse 6-12. Ke habohlokoa ho hlokomela hore ho ja ha ho ame lithethefatsi.

Matla a gliclazide e etselitsoe ho khothaletsa tlhahiso ea insulin ke lisele tsa beta tsa manyeme. Ntle le moo, ntho ena e na le phello ea hemovascular, ke hore, e fokotsa monyetla oa thrombosis ka likepeng tse nyane. Gliclazide e batla e kolobisitsoe ka botlalo ho sebete.

Bokantle ba ntho bo hlaha ka thuso ea liphio.

Litaelo tsa tšebeliso ea lithethefatsi

Moetsi o hlahisa moriana ka mokhoa oa litafole tsa litekanyetso tse fapaneng (30 le 60 mg), ho feta moo, ke bakuli ba baholo feela ba ka li noang.

Diabeteson MV 30 mg e ka rekoa khemising feela ka lengolo la ngaka. Ka hona, ngaka e beha qeto ea hore na ho ka sebelisoa lipilisi tsena joang, ha ho fuoa boemo ba glycemia le boemo ba bophelo bo botle ba mokuli.

Ho khothalletsoa ho nka moriana hang ka letsatsi nakong ea lijo tsa hoseng. Ho etsa sena, letlapa le lokela ho metsoa le ho hlatsuoa ka metsi ntle le ho hlafuna. Haeba mokuli a lebetse ho noa pilisi ka nako, ho lumeletsoe habeli tekanyetso ea moriana.

Litekanyetso tsa pele tsa hypoglycemic ke 30 mg ka letsatsi (1 kiba). Ka mokhoa o sa laoloeng oa lefu la tsoekere, mokhoa ona o ka fana ka taolo e lekaneng ea maemo a tsoekere. Ho seng joalo, ngaka ka boeona e eketsa litekanyetso tsa moriana ho mokuli, empa eseng pele ho matsatsi a 30 ka mor'a ho nka tekanyetso ea pele. Motho e moholo o lumelloa ho ja ka hohle kamoo ho ka khonehang ka letsatsi Diabeteson MV 30 ho isa ho 120 mg.

Ho na le litemoso tse ling mabapi le ts'ebeliso ea lithethefatsi ho batho ba lilemo tse fetang 60, hammoho le bakuli ba nang le tahi, ho nyekeloa ke meno kapa lefu la sebete, khaello ea glucose-6-phosphate dehydrogenase, khaello ea pituitary kapa adrenal, pelo le methapo ea methapo ea kutlo. Maemong a joalo, setsebi se khetha litekanyetso tsa moriana ka hloko.

Litaelo tse kentsoeng li re moriana o lokela ho bolokoa ka 30 ° C hole le bana ba banyenyane. Bophelo ba sehatsetsi bo lokela ho bontšoa ka har'a lipakete.

Kamora nako ena, meriana ha ea lumelloa.

Contraindra le kotsi e ka bang teng

Diabeteson MV 30 mg e tšoaetsanoe ho bakuli ba ka tlase ho lilemo tse 18. Qobello ena e bakoa ke khaello ea ya data mabapi le polokeho ea lichelete bakeng sa bana le bacha.

Hape ha ho na boiphihlelo bo sebelisang moemeli oa hypoglycemic nakong ea kemolo le ho lactation. Nakong ea kemaro, khetho e nepahetseng ka ho fetisisa ea ho laola glycemia ke kalafo ea insulin. Tabeng ea ho rera ho ima, u tla tlameha ho khaotsa ho sebelisa lithethefatsi tse theolelang tsoekere le ho chencha liente tsa li-hormone.

Ntle le li-contraindication tse kaholimo, leqephe la taelo le na le lethathamo la maloetse le maemo ao ho ona Diabeteson MV 30 e thibetsoeng ho e sebelisa. Tsena li kenyeletsa:

• lefu la tsoekere le itšetlehileng ka insulin
• Tšebeliso e tšoanang ea miconazole,
• lefu la tsoekere ketoacidosis,
• hypersensitivity ho likarolo tsa mantlha kapa tse thusang,
• lefu la tsoekere le letšollo,
• hepatic le / kapa ho se sebetse hantle haholo (ka sebopeho se matla).

Ka lebaka la tšebeliso e fosahetseng kapa boitšoaro bo feteletseng, ho ka ba le karabelo e sa rateheng. Haeba li etsahala, o lokela ho khaotsa ho sebelisa sethethefatsi sena mme ka potlako u batle thuso ho ngaka. U kanna ua hloka ho emisa ho e sebelisa haeba litletlebo tsa mokuli li amana le:

1. Ka ho theoha ka sekhahla ha maemo a tsoekere.
2. Ka maikutlo a sa feleng a tlala le mokhathala o eketsehileng.
3. Ka pherekano le ho akheha.
4. Ka ho nyehla, ho nyekeloa le pelo le ho hlatsa.
5. Ka ho opeloa ke hlooho le ho tsekela.
6. Ka tlhokomelo e fokolisang ea tlhokomelo.
7. Ka phefumoloho e sa tebang.
8. Ka pono le puo e sa sebetseng.
9. Ka ho ruruha, ho se utloane le khatello ea maikutlo.
10. Ka mokokotlo oa mokokotlo oa mesifa.
11. Ka khatello e phahameng ea mali.
12. Ka bradycardia, tachycardia, angina pectoris.
13. Ka karabelo ea letlalo (ho hlohlona, ​​lekhopho, erythema, urticaria, Quincke edema).
14. Ka karabelo e matla.
15. Ka mofufutso o eketsehileng.

Letšoao le ka sehloohong la overdose ke hypoglycemia, e ka felisoang ka lijo tse nang le lik'habohaedreite tse bonolo tse tsoekere (tsoekere, chokolete, litholoana tse monate). Ka mokhoa o tebileng le ho feta, ha mokuli a ka akheha kapa a oela, o tlameha ho kena sepetlele ka potlako. Mokhoa o mong oa ho etsa hore tsoekere e khutsitseng ka tsela e tloaelehileng ke ka ho tsamaisa tsoekere. Haeba ho hlokahala, kalafo ea matšoao e etsoa.

Ho kopanya le mekhoa e meng

Ha ho na le mafu a kopaneng, ho bohlokoa haholo hore mokuli a tlalehele ngaka ea hae ea bongaka. Ho boloka tlhahisoleseling ea bohlokoa joalo ho ka ama hampe litlamorao tsa lithethefatsi tsa lefu la tsoekere MV ka boeona.

Joalokaha u tseba, ho na le lithethefatsi tse 'maloa tse ka ntlafatsang kapa, ka lehlakoreng le leng, li fokolisa katleho ea moemeli oa hypoglycemic. Tse ling tsa tsona li ka baka litlamorao tse ling tse sa rateheng.

Meriana le lisebelisoa tse eketsang monyetla oa hypoglycemia:

1. Miconazole
2. Phenylbutazone.
3. Ethanol
4. Sulfonamides.
5. Thiazolidinidones.
6. Acarbose.
7. Ultrashort insulin.
8. Lithethefatsi tse seng khahlanong le ho ruruha.
9. Clarithromycin
10. Metformin.
11. GPP-1 agonists.
12. MAO inhibitors.
13. Li-inhibitors tsa Dipeptidyl peptidase-4.
14. Beta blockers.
15. Li-inhibitors tsa ACE.
16. Fluconazole
17. Li-blockers tsa H2-histamine receptor.

Meriana le lisebelisoa tse eketsang monyetla oa hyperglycemia:

• Danazole
• Chlorpromazine
• Glucocorticosteroids,
• Tetracosactide,
• Salbutamol,
• Ritodrin
• Terbutaline.

Ho lokela ho hopoloa hore tsamaiso e tšoanang ea tharollo ea sulfonylurea le anticoagulants e ka ntlafatsa phello ea morao. Ka hona, maemong a mang, ho hlokahala hore u fetole litekanyetso tsa bona.

Bakeng sa ho qoba karabelo efe kapa efe e mpe, mokuli o lokela ho ea ho setsebi se ka lekolang tšebelisano ea lithethefatsi hantle.

Lintho tse amang katleho ea sethethefatsi

Ha se meriana feela kapa lithethefatsi tse fetang tekano li ka amang katleho ea mofani oa lefu la tsoekere la Diabeteson MV 30. Ho na le lintlha tse ling tse amang boemo ba bophelo ba motho ea nang le lefu la tsoekere.

Lebaka la pele le atileng haholo la kalafo e sa kopaneng ke ho hana kapa ho se khonehe ha bakuli (haholo-holo ba baholo) ho laola boemo ba bona ba bophelo bo botle le ho latela litlhahiso tsohle tsa ngaka e eang.

Ntlha ea bobeli, ea bohlokoa ka ho tšoanang ke lijo tse sa leka-lekanang kapa lijo tse se nang moeli. Hape, katleho ea moriana o angoa ke tlala, likheo tsa ho amoheloa le phetoho lijong tse tloaelehileng.

Ntle le moo, bakeng sa kalafo e atlehileng, mokuli o tlameha ho laola palo ea lik'habohaedreite tse sebelisoang le ho ikoetlisa. Ho kheloha hofe kapa hofe ho ama tsoekere ea mali le bophelo bo botle.

Ho joalo, maloetse a kopaneng a bapala karolo ea bohlokoa. Pele ho tsohle, tsena ke li-pathologies tsa endocrine tse amanang le tšoelesa ea qoqotho le pituitary gland, hammoho le ho hloleha ho matla ha renal le hepatic.

Ka hona, ho fihlela botsitso ba boleng ba tsoekere le ho felisa matšoao a lefu la tsoekere, mokuli le ngaka ea hae e fanang ka kalafo ba hloka ho hlola kapa bonyane ho fokotsa tšusumetso ea lintlha tse kaholimo.

Litšenyehelo, litekolo le li-analogues

Lithethefatsi Diabeteson MV 30 mg e ka rekoa khemising efe kapa efe kapa ea odara marang-rang ho webosaete ea semolao ea morekisi. Litsenyehelo tsa moriana li latela palo ea matlapa a sephutheloaneng. Kahoo, theko ea sephutheloana se nang le matlapa a 30 a 30 mg ka 'ngoe e tloha ho 255 ho isa ho 288 li-ruble,' me theko ea sephutheloana se nang le matlapa a 60 a 30 mg ka 'ngoe e tloha ho li-ruble tse 300 ho isa ho tse 340.

Joalokaha u bona, lithethefatsi li ka fumaneha ho mokuli ka boemo bofe kapa bofe ba moputso, boo, ke tlatsetso e kholo. Kamora ho hlahloba litlhahlobo tse ntle tsa batho ba nang le lefu la tsoekere, re ka fihlela qeto mabapi le moriana ona:

1. Ho bonolo ho e sebelisa hammoho le liente tsa insulin.
2. Kotsi e tlase ea karabelo e mpe.
3. Ho tsitsa ha glycemia.

Leha ho le joalo, maemong a mang, ho ne ho fokotseha ka sekhahla sa maemo a tsoekere, a ileng a felisoa ka ho nka limatlafatsi tsa mmele. Ka kakaretso, maikutlo a lingaka le bakuli mabapi le lithethefatsi ke a nepahetseng. Ka tšebeliso e nepahetseng ea matlapa le ho latela litlhahiso tsohle tsa ngaka, u ka fihlela maemo a tloaelehileng a tsoekere le ho qoba litlamorao. Ho tlameha ho hopotsoa hore ke bakuli feela ba:

• khomarela phepo e nepahetseng,
• bapala lipapali
• boloka botsitso pakeng tsa ho phomola le ho sebetsa,
• laola tsoekere
• leka ho qoba ho sithabela maikutlo le khatello ea maikutlo.

Ba bang ba sebelisa moriana ona moahong oa 'mele ho eketsa boima ba mesifa. Leha ho le joalo, lingaka li lemosa tšebeliso ea lithethefatsi ka sepheo se seng.

Ka nts'etsopele ea karabelo e mpe kapa mabapi le li-contraindication, ngaka e na le bothata ba ho khethoa ha moriana o mong o ka bang le phello e tšoanang ea kalafo. Diabeteson MV e na le li-analogues tse ngata. Mohlala, hara lithethefatsi tse nang le "gliclazide" e sebetsang, tse tsebahalang haholo ke:

1. Glidiab MV (li-ruble tse 140),
2. Glyclazide MV (li-ruble tse 130),
3. Diabetesalong (li-ruble tse 105),
4. Diabefarm MV (li-ruble tse 125).

Har'a litokisetso tse nang le lintho tse ling, empa ho ba le phello e ts'oanang ea hypoglycemic, motho a ka khetholla Glemaz, Amaril, Gliclada, Glimepirid, Glyurenorm, Diamerid le ba bang.

Hoa bohlokoa ho hlokomela hore ha u khetha moriana, mokuli ha a tsotelle ts'ebetso ea ona feela, empa le litšenyehelo tsa eona. Palo e kholo ea li-analogues e etsa hore ho khonehe ho khetha khetho e nepahetseng ka ho fetisisa bakeng sa karo-karo ea theko le boleng.

Diabeteson MV 30 mg - sesebelisoa se sebetsang kalafo ea lefu la tsoekere la mofuta oa 2. Ha e sebelisoa ka nepo, moriana o tla thusa ho fokotsa sethala sa tsoekere 'me u lebale ka matšoao a "lefu le monate" ka nako e telele. Ntho ea bohlokoa ke ho se lebale ka litaelo tsa ngaka le ho phela bophelo bo phetseng hantle.

Setsebi se hlahang video e sehloohong sena se tla bua ka likarolo tsa meriana le lefu la tsoekere.

Foromo ea boholo:

Moetso:
Letlapa le leng le na le:
Lintho tse sebetsang: gliclazide - 30.0 mg.
Baeti: calcium hydrogen phosphate dihydrate 83.64 mg, hypromellose 100 cP 18.0 mg, hypromellose 4000 cP 16.0 mg, magnesium stearate 0.8 mg, maltodextrin 11.24 mg, anhydrous colloidal silicon dioxide 0,32 mg.

Tlhaloso
Matlapa a tšoeu a biconvex oval a ngotsoe ka "DIA 30" ka lehlakoreng le leng 'me letšoao la k'hamphani le ka lehlakoreng le leng.

Sehlopha sa Pharmacotherapeutic:

TLHALOSO YA PHARMACOLOGICAL
Pharadodynamics
Glyclazide ke sulfonylurea derivative, sethethefatsi sa hypoglycemic bakeng sa tsamaiso ea molomo, se fapaneng le lithethefatsi tse tšoanang ka boteng ba N - e nang le reng ea heterocyclic e nang le endocyclic bond.
Glyclazide e fokotsa bongata ba tsoekere ea mali, e tsosetsang sephiri sa insulin ka li-b-cell tsa li-islets tsa Langerhans. Keketseho ea khatello ea mali ea postprandial insulin le C-peptide e phehella kamora lilemo tse peli tsa kalafo.
Ntle le phello ea metabolism ea carbohydrate, gliclazide e na le litlamorao tsa hemovascular.
Kameho ho secretion ea insulin
Ho mofuta oa 2 lefu la tsoekere, lithethefatsi li khutlisa tlhoko ea pele ea "insulin secretion" ho arabela tšebeliso ea tsoekere le ho matlafatsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e bonoa ho arabela ho ts'oaroa ka lebaka la takatso ea lijo kapa tsamaiso ea tsoekere.
Litla-morao tsa pelo
Glyclazide e fokotsa kotsi ea ts'ebetso ea methapo e fokolang ea mali ts'ebetso e eketsehileng ea activator ea tisy ea plasminogen.
Taolo e matla ea glycemic e thehiloeng ts'ebelisong ea Diabeton® MV (HbA1c Leano la taolo e matla ea glycemic le kenyelelitse ho beoa ha moriana Diabeteson® MV le ho eketsa tekanyetso ea eona khahlanong le semelo sa (kapa ho e-na le ... kalafo e tloaelehileng pele o eketsa lithethefatsi tse ling tsa hypoglycemic (mohlala, metformin, alpha-glucosidase inhibitor ho eona) , derivative of thiazolidinedione kapa insulin. Karolelano ea litekanyetso tsa letsatsi le letsatsi tsa lithethefatsi Diabeteson® MV ho bakuli ba sehlopha se matla sa taolo e ne e le 103 mg, e phahameng ka ho fetisisa letsatsi le letsatsi lethal dose e ne e 120 mg,.
Khahlano le nalane ea ts'ebeliso ea lithethefatsi Diabeteson ® MV sehlopheng se matla sa taolo ea glycemic (nako ea ho latela lilemo tse 4,8, tekanyo ea HbA1c ea 6.5%) ha e bapisoa le sehlopha se laoloang (kakaretso ea HbA1c level 7.3%), ho bontšoa ho fokotseha ho hoholo ha 10% kotsi e lekanang ea maqhubu a kopaneng a mathata a maholo ka ho fetisisa le a manyane
Monyetla ona o fumanoe ka ho fokotsa kotsi e kaalo: mathata a maholo a microvascular ka 14%, ho qala le ho tsoelapele ha nephropathy ka 21%, ho hlaha ha microalbuminuria ka 9%, macroalbuminuria ka 30% le nts'etsopele ea mathata a renal ka 11%.
Melemo ea taolo ea glycemic e matla ha u ntse u nka Diabeton® MV ha ea ka ea itšetleha ka melemo e fumanoeng ka kalafo ea antihypertensive.

Mofumahali
Kamora ho tsamaisoa ka molomo, gliclazide e kenella ka botlalo. Ho bokellana ha gliclazide ho plasma ho eketseha butle butle, ho fihla sehlabeng kamora lihora tse 6-12. Phapang ea motho ka mong e tlaase.
Ho ja ha ho ame tekanyo ea ho amoheloa ha moriana. Kamano pakeng tsa tekanyo e nkuoeng (ho fihlela ho 120 mg) le sebaka se ka tlasa "pharmacokinetic curve" nthawi ea mahloriso "se mela. Hoo e ka bang 95% ea lithethefatsi li tlama ho protheine ea plasma. Glyclazide e tšelisoa haholo ka har'a sebete 'me e hloekisoa haholo ke liphio: excretion e etsoa ka sebopeho sa metabolites, e ka tlase ho 1% e hlahisoa ke liphio li sa fetohe. Ha ho na metabolites e sebetsang ho plasma.
Bophelo ba halofo ea gliclazide ke karolelano ea lihora tse 12 ho isa ho tse 20. Bophahamo ba kabo ea thepa e ka ba lilithara tse 30.
Ho batho ba tsofetseng, ha ho na liphetoho tse kholo maemong a pharmacokinetic.
Ho nka moriana oa lefu la tsoekere la Diabeteson ® MV ka lethal dose ea 30 mg hang ka letsatsi ho tiisa hore ho na le ts'ebetso ea "gliclazide" e sebetsang hantle ka har'a plasma ea mali ka nako e fetang lihora tse 24.

LIPUO TSA SEBELISO
Type 2 lefu la tsoekere la mellitus le sa sebetsang hantle kalafo ea ho ja, ho ikoetlisa le ho theola boima ba 'mele.
Thibelo ea mathata a lefu la tsoekere: ho fokotsa kotsi ea mathata a amanang le lefu la sethoathoa (lefu la pelo le lefu la sethoathoa, stroke) ho bakuli ba nang le mofuta oa 2 lefu la tsoekere ka taolo e matla ea glycemic.

• hypersensitivity ho gliclazide, tse ling tse tsoang ho sulfonylurea, sulfonamides kapa ho li-excipients tseo e leng karolo ea lithethefatsi,
• mofuta oa 1 lefu la tsoekere
• lefu la tsoekere ketoacidosis, lefu la tsoekere, lefu la tsoekere,
• ho ruruha haholo kapa ho fokola ha sebete (maemong ana, ho khothalletsoa ho sebelisa insulin)
• Phekolo e kopanetsoeng le miconazole (bona karolo "Ho sebelisana le lithethefatsi tse ling"),
• nako ea kemaro le kemaro ea pelehi (bona karolo "Nako ea kemaro le nako ea pelehi"),
• lilemo tse 18.

Ha e khothalletsoe ho sebelisoa hammoho le phenylbutazone le danazole (bona karolo "Tšebelisano le lithethefatsi tse ling").
Ka tlhokomelo:
Ho tsofala, ho se lekane le / kapa phepo e sa leka-lekanang, khaello ea glucose-6-phosphate dehydrogenase, mafu a matla a tsamaiso ea methapo ea pelo, hypothyroidism, adrenal kapa pituitary insuffence, renal le / kapa ho hloleha ha sebete, kalafo ea nako e telele le glucocorticosteroids (GCS), botahoa.

MOTSOALLE OA HO FIHLA LE HO FINYELETSA PELE
Boimana
Ha ho na boiphihlelo ka gliclazide nakong ea kemolo. Lintlha tse mabapi le tšebeliso ea tse ling tse tsoang sulfonylurea nakong ea kemaro li na le moeli.
Boithutong ba liphoofolo tse sebelisoang ka laboratoring, litla-morao tsa "gliclazide" ha li so tsejoe.
Ho fokotsa kotsi ea tšoaetso ea tlhaho ea tlhaho, ho hlokahala hore ho laoloe hantle (kalafo e nepahetseng) ea lefu la tsoekere.
Lithethefatsi tsa molomo tsa molomo nakong ea kemolo ha li sebelisoe.
Insulin ke lithethefatsi tsa khetho bakeng sa kalafo ea lefu la tsoekere ho basali baimana.
Ho khothalletsoa ho nka sebaka sa ts'ebeliso ea lithethefatsi tsa molomo tsa hypoglycemic ka kalafo ea insulin ka bobeli nakong ea kemaro e reriloeng, le hore na ho ima ho etsahetse ha u ntse u sebelisa moriana.
Lebone
Ka ho nahana ka ho haella ha tlhaiso-leseling mabapi le ho kenella ha gliclazide ka lebese la matsoele le kotsi ea ho ba le hypoglycemia ho ngoana ea anyesitsoeng, ho anyesa ho kopantsoe le nakong ea kalafo le moriana ona.

TLHALOSO LE PUSO
LITLHAKU TSE BUANG HO SEBELISOA FEELA HO BULETSA BATSOALI.
Tekanyetso e khothalletsoang ea lithethefatsi (matlapa a 1-4, 30-120 mg) e lokela ho nooa ka molomo, nako e le 1 ka letsatsi, haholo-holo nakong ea lijo tsa hoseng.
Ho khothalletsoa hore letlapa leo le me le felle ntle le ho hlafuna kapa ho silafatsoe.
Haeba u fetoa ke tekanyetso e le 'ngoe kapa tse' maloa tsa moriana, u ke ke ua nka tekanyetso e phahameng ho lethal e latelang, tekanyetso e lahlehileng e lokela ho nooa ka le hlahlamang.
Joalo ka lithethefatsi tse ling tsa hypoglycemic, lethal dose la lithethefatsi ka bomong le tlameha ho khethoa ka bonngoe, ho latela bongata ba glucose ea mali le glycosylated hemoglobin (HbA1c).
Tekanyetso ea pele
Tekanyetso ea pele e khothalletsoang (ho kenyeletsoa bakuli ba tsofetseng, ≥ lilemo tse 65) ke 30 mg ka letsatsi.
Tabeng ea taolo e lekaneng, sethethefatsi tekanyetso ena se ka sebelisoa bakeng sa kalafo ea tlhokomelo. Ka taolo e sa lekaneng ea glycemic, tekanyetso ea letsatsi le letsatsi ea lithethefatsi e ka eketseha ka tatellano ho isa ho 60, 90 kapa 120 mg.
Keketseho ea lethal dose e khonahala eseng pele ho khoeli ea 1 ea kalafo ea lithethefatsi ka tekanyetso e boletsoeng esale pele. Mokhelo ke bakuli bao khatello ea bona ea tsoekere ea mali e sa fokotsehang kamora libeke tse peli tsa kalafo. Maemong a joalo, tekanyetso e ka eketseha libeke tse 2 kamora ho qala tsamaiso.
Tekanyo e phahameng ka ho fetisisa e khothalletsoang ea letsatsi le letsatsi ea lithethefatsi ke 120 mg.

Ho tloha ho lefu la tsoekere ® Matlapa a 80 mg ho lekhoba la lefu la tsoekere ® Matlapa a lokolotsoeng a 30 mg
Letlapa le le leng la lithethefatsi Diabeteson ® 80 mg le ka nkeloa sebaka ke letlapa le le leng le nang le tlhahiso ea lefu la tsoekere la Diabeteson ® MV 30 mg. Ha u fetisetsa bakuli ho tloha ho Diabeteson ® 80 mg ho Diabeteson ® MV, ho kgothaletswa taolo ea glycemic ka hloko.
Ho tloha ho sethethefatsi se seng sa hypoglycemic ho ea Diabeton ® Matlapa a lokolotsoeng a 30 mg
Litafole tsa Diabeteson ® MV ea lithethefatsi tse nang le tlhahiso e fetotsoeng ea 30 mg li ka sebelisoa sebakeng sa lithethefatsi tse ling tsa hypoglycemic bakeng sa tsamaiso ea molomo. Ha u fetisetsa bakuli ba fumanang lithethefatsi tse ling tsa hypoglycemic bakeng sa tsamaiso ea molomo ho Diabeteson ® MV, tekanyo ea bona le halofo ea bophelo e lokela ho ananeloa. Ha e le molao, nako ea phetoho ha e hlokehe.
Tekanyetso ea pele e lokela ho ba 30 mg mme ebe ea kenngoa ka bongata ho latela bongata ba tsoekere ea mali.
Ha lefu la tsoekere la Diabeteson ® MV le nkeloa sebaka ke lipolao tsa sulfonylurea nako e telele ea halofo ea bophelo ho qoba hypoglycemia e bakoang ke ts'usumetso e eketsang ea liakhente tse peli tsa hypoglycemic, o ka emisa ho li nka matsatsi a 'maloa. Tekanyetso ea pele ea lithethefatsi Diabeteson ® MV le eona e fihla ho 30 mg mme, haeba ho hlokahala, e ka eketsoa nakong e tlang, joalo ka ha ho hlalositsoe kaholimo.
Tšebeliso e kopantsoeng le moriana o mong oa hypoglycemic
Diabeteson ® MB e ka sebelisoa hammoho le biguanides, alpha-glucosidase inhibitors kapa insulin.
Ka taolo e sa lekaneng ea glycemic, kalafo e eketsehileng ea insulin e lokela ho beoa ka tlhahlobo e hlokolosi ea bongaka.

Bakuli ba baholo
Phetoho ea khaba bakeng sa bakuli ba lilemo tse fetang 65 ha e ea hlokahala.

Bakuli ba nang le ho hloleha ha meno Liphetho tsa lithuto tsa kliniki li bonts'itse hore phetoho ea lethal dose ho bakuli ba nang le phofshoana ea ho hlaphoheloa ha ausi ha e hlokehe. Ho hlahlojoa tlhokomelo ea bongaka e haufi.
Bakuli ba Kotsi ea Hypoglycemia
Ho bakuli ba kotsing ea ho ba le hypoglycemia (phepo e sa lekaneng kapa e sa leka-lekanang, mathata a endocrine a matla kapa a sa fumaneng hantle - ho hloka tlhokomelo ea boemo bo holimo le lefu la ho hloleha ho phekola maloetse (glucocorticosteroids (GCS) kamora ts'ebeliso e telele le / kapa tsamaiso litekanyetso tse phahameng, lefu la pelo le matla haholo. tsamaiso ea methapo ea methapo - lefu le matla la pelo, lefu le matla la carotid, lefu le tloaelehileng la tšebetso ea methapo), ho khothalletsoa ho sebelisa lethalinyana (30 mg) la prep Ata Diabeton ® MV.

Thibelo ea mathata a lefu la tsoekere
Ho fihlella taolo e matla ea glycemic, butle-butle o ka eketsa tekanyetso ea lithethefatsi Diabeteson ® MV ho isa ho 120 mg / letsatsi ho kenyelletsa lijo le ho ikoetlisa ho fihlela boemo ba sepheo sa HbA1c. Hopola kotsi ea ho ba le hypoglycemia. Ntle le moo, lithethefatsi tse ling tsa hypoglycemic, mohlala, metformin, alpha glucosidase nigibitor, thiazolidatedione derivative kapa insulin, li ka eketsoa ho tsa bongaka.

Bana le bacha ba ka tlase ho lilemo tse 18.
Lintlha tse mabapi le katleho le polokeho ea lithethefatsi ho bana le bacha ba ka tlase ho lilemo tse 18 ha li fumanehe.

PUSELETSO MAHALA
Ha ho fanoa ka boiphihlelo ka gliclazide le tse ling tse tsoang ho sulfonylurea, litlamorao tse latelang li lokela ho tsotelloa.
Hypoglycemia
Joalo ka lithethefatsi tse ling tsa sehlopha sa sulfonylurea, Diabeteson ® MV e ka baka hypoglycemia haeba ho ka ba le lijo tse seng molaong, haholo-holo haeba lijo li sa fumanehe. Matšoao a ka bang teng a hypoglycemia: hlooho e opang, tlala e matla, ho nyekeloa, ho felloa ke matla, ho tšoenyeha ka boroko, ho teneha, ho fokotseha ha tlhokomelo, ho lieha ho arabela, khatello ea maikutlo, pherekano, pono e fifalitsoeng le puo, aphasia, thothomelo, pono , ho tsekela, ho fokola, ho tsitsipana, bradycardia, delirium, ho hloleha ho phefumoloha, ho otsela, ho lahleheloa ke kelello ka tsoelo-pele ea lefu la ho akheha, ho fihlela lefung.
Boitšoaro ba Andrenergic bo ka boela ba hlokomeleha: mofufutso o eketsehileng, letlalo "letheba", ho tšoenyeha, tachycardia, khatello e phahameng ea mali, palpitations, arrhythmia, le angina pectoris.
Ha e le molao, matšoao a hypoglycemia a emisoa ka ho nka limatlafatsi (tsoekere).
Ho nka li-sweeteners ha ho na thuso. Khahlano le semelo sa tse ling tse tlisoang ke sulfonylurea, liphapang tsa hypoglycemia li ile tsa lemohuoa kamora phomolo e atlehileng.
Ho hypoglycemia e matla kapa ea nako e telele, ho bontšoa tlhokomelo ea bongaka ea tšohanyetso, mohlomong ka ho kena sepetlele, le haeba ho e-na le phello ea ho nka lik'habohaedreite.

Litla-morao tse ling

• Ho tsoa pampiring ea ka mpeng: bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho sokela. Ho nwa moriana nakong ea lijo tsa hoseng ho qoba matšoao ana kapa ho a fokotsa.

Litlamorao tse latelang ha li sa tloaeleha:

• Karolong ea letlalo le lisele tse potolohileng: lekhopho, ho hlohlona, ​​urticaria, erythema, lekhopho la maculopapullous, lekhopho le matla.
• Ho tsoa lits'ebetsong tsa potoloho ea mali le li-lymphatic: mathata a hematological (anemia, leukopenia, thrombocytopenia, granulocytopenia) ke seoelo. Joaloka molao, liketsahalo tsena lia fetoha haeba phekolo e khaotsa.
• Karolong ea sebete le pampitšana ea biliary: ts'ebetso e eketsehileng ea li-enzymes tsa "sebete" (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (linyeoe tse ikhethileng). Haeba choleundatic jaundice e etsahala, phekolo e lokela ho khaotsa.

Litlamorao tse latelang li atisa ho fetoha ha phekolo e khaotsa.

• Ho tloha lehlakoreng la setho sa pono: Litšitiso tsa nakoana tsa pono li ka hlaha ka lebaka la phetoho ea khatello ea tsoekere ea mali, haholoholo qalong ea kalafo.
• Litla-morao tse hlahisoang ke sulfonylurea derivatives: ha u ntse u nka li-derivatives tse ling tsa sulfonylurea, litlamorao tse latelang tsa bonoa: erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, allergic vasculitis le hyponatremia. Ho bile le keketseho ea ts'ebetso ea li-enzyme tsa "sebete", ts'ebetso ea ho se sebetse hantle ha sebete (mohlala, ka nts'etsopele ea cholestasis le jaundice), lipontšo li ile tsa fokotseha ka mor'a nako kamora ho khaotsa litokisetso tsa sulfonylurea, empa maemong a mang ho lebisitse ho se atleheng ha sebete.

Litla-morao tse lemohileng litekong tsa bongaka
Phuputsong ea ADVANCE, ho bile le phapang e nyane khafetsa ea liketsahalo tse mpe tse mpe tse mpe lipakeng tsa lihlopha tsena tse peli tsa bakuli. Ha ho lintlha tse ncha tsa polokeho tse fumanoeng. Palo e fokolang ea bakuli e ne e e-na le hypoglycemia e matla, empa kakaretso ea hypoglycemia e ne e le tlase. Kotsi ea hypoglycemia sehlopheng se matla sa taolo ea glycemic e ne e phahame ho feta sehlopheng se laoloang ke glycemic. Likarolo tse ngata tsa hypoglycemia sehlopheng se matla sa taolo ea glycemic li ile tsa bonoa khahlano le semelo sa phekolo ea insulin.

PUSELETSO
Haeba ho na le lithethefatsi tse ngata tse tsoang ho sulfonylurea, ho ka hlaha hypoglycemia.
Haeba u ba le matšoao a bobebe a hypoglycemia ntle le ho lemala kapa matšoao a methapo, o lokela ho eketsa tekanyo ea lik'habohaedreite ka lijo, fokotsa tekanyo ea lithethefatsi le / kapa ho fetola lijo. Tlhahlobo ea bongaka ea haufi le boemo ba mokuli e lokela ho tsoela pele ho fihlela ho ba le tšepo ea hore ha ho na letho le sokelang bophelo ba hae.
Mohlomong nts'etsopele ea maemo a matla a hypoglycemic, e tsamaeang le komisi, ho akheha kapa mathata a mang a methapo ea methapo. Haeba matšoao a joalo a hlaha, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka le ho kena sepetlele hang-hang.
Maemong a coma ea hypoglycemic kapa haeba ho belaelloa, mokuli o kenngoa kahare ka methapo e 50 ml ea tharollo ea 20-30% dextrose (glucose). Ebe tharollo ea 10% ea dextrose e tsamaisoa ka mokhoa o tlohang ho boloka khatello ea tsoekere ea mali ka holimo ho 1 g / L. Ho lekola ka hloko tsoekere ea mali le ho hlahloba mokuli ho lokela ho etsoa bonyane lihora tse 48 tse latelang.
Kamora nako ena ea nako, ho latela boemo ba mokuli, ngaka e eang e nka qeto ea tlhoko ea tlhahlobo e ngoe hape. Ho buoa ka methapo ha ho na thuso ka lebaka la ho tlangoa ha gliclazide liprotheine tsa plasma.

KAMANO LE LITLHAKISO TSE LING
1) Lithethefatsi tse eketsang kotsi ea hypoglycemia:
(ho ntlafatsa phello ea gliclazide)
Motsoako o kopantsoeng
- Miconazole (ka tsamaiso ea methapo le ha o sebelisa li-gel ho mucosa ea molomo): e ntlafatsa phello ea hypoglycemic ea gliclazide (hypoglycemia e ka nyolohela ho komisi).
Ha e khothalletsoe motsoako
- Phenylbutazone (Tsamaiso ea tsamaiso): e ntlafatsa phello ea hypoglycemic ea lintho tse tsoang ho sulfonylurea (e li tlosa hole le puisano le liprotheine tsa plasma le / kapa e liehisa ho tsoa ha tsona 'meleng).
Ho molemo ho sebelisa sethethefatsi se seng se thibelang mafu. Haeba phenylbutazone e hlokahala, mokuli o lokela ho lemosoa ka tlhokahalo ea taolo ea glycemic. Haeba ho hlokahala, tekanyetso ea lithethefatsi Diabeteson ® MV e lokela ho fetoloa ha o ntse o nka phenylbutazone le kamora eona.
- Ethanol: e ntlafatsa hypoglycemia, e thibela mats'oafo a karabelo, e ka kenya letsoho kholisong ea komello ea hypoglycemic. Hoa hlokahala ho hana ho nka meriana, e kenyang ethanol le lino tse tahang.
Litlhokomelo
Gliclazide ha e kopana le lithethefatsi tse ling (mohlala, li-agents tse ling tsa hypoglycemic - insulin, alpha glucosidase inhibitor, biguanides, beta-blockers, fluconazole, angiotensin-converting inhibitors - Captopril, enalapril, H2S-histamine inhibitors lithethefatsi tse khahlanong le ho ruruha) li tsamaisana le keketseho ea phello ea hypoglycemic le kotsi ea hypoglycemia.
2) Lithethefatsi tse eketsang tsoekere ea mali:
(phello e fokotsang ea gliclazide)
Ha e khothalletsoe motsoako
- Danazole: e na le lefu la tsoekere. Haeba ho sebelisa lithethefatsi tsena hoa hlokahala, mokuli o khothalletsoa ho laola taolo ea glycemic ka hloko. Haeba ho hlokahala, tsamaiso e kopanetsoeng ea lithethefatsi, ho khothalletsoa hore tekanyetso ea moemeli oa hypoglycemic e khethoe ka bobeli nakong ea tsamaiso ea danazol le ka mor'a ho tlohela.
Litlhokomelo
- Chlorpromazine (antipsychotic): litekanyetso tse phahameng (tse fetang 100 mg ka letsatsi) e eketsa tsoekere e maling, e fokotsa sekhahla sa insulin.
Ho khothalletsoa taolo ea glycemic ka hloko. Haeba ho hlokahala, tsamaiso e kopanetsoeng ea lithethefatsi, ho khothalletsoa hore ho khethoe lethaliti la moemeli oa hypoglycemic, ka bobeli nakong ea tsamaiso ea antipsychotic le ka mor'a ho tlohela.
- SCS (Ts'ebetso ea methapo le ea lehae: tsamaiso ea methapo, letlalo, tsamaiso ea methapo): eketsa tsoekere ea mali ka nts'etsopele ea ketoacidosis (ho fokotseha ha mamello ho lik'habohaedreite). Ho laoloa ka hloko glycemic, haholo-holo qalong ea kalafo. Haeba ho hlokahala hore ho sebelisoe lithethefatsi mmoho, phetoho ea moemeli ea hypoglycemic e ka hlokahala ka bobeli nakong ea tsamaiso ea GCS le kamora ho itokolla.
- Ritodrin, salbutamol, terbutaline (Tsamaiso ea methapo): aga-2 adrenergic agonists e eketsa khatello ea tsoekere ea mali.
Ho lebisoa tlhokomelo e khethehileng ho bohlokoa ba taolo ea glycemic. Haeba ho hlokahala, ho khothalletsoa ho fetisetsa mokuli kalafo ea insulin.
3) Metsoako e lokelang ho ananeloa
- Li-Anticoagulants (mohlala warfarin)
Liphetho tsa sulfonylureas li ka ntlafatsa phello ea li-anticoagulants ha li kopane. Ho ka 'na ha hlokahala hore u ntlafatse tokiso ea litheko tsa anticoagulant.

TLHOKOMELISO LITLHAKISO
Hypoglycemia
Ha u nka lintho tse tsoang ho sulfonylurea, ho kenyelletsa le gliclazide, hypoglycemia e ka hlaha, maemong a mang e le ka sebopeho se matla le sa nako e telele, se hlokang ho kena sepetlele le tsamaiso e matla ea tharollo ea dextrose ka matsatsi a 'maloa (bona karolo ea "Litla-morao".
Setlhare se ka fuoa feela bakuli bao lijo tsa bona li leng teng khafetsa 'me li kenyelletsa lijo tsa hoseng. Ho bohlokoa haholo ho boloka phepelo e lekaneng ea lik'habohaedreite ka lijo, kaha menyetla ea ho ba le hypoglycemia e eketseha ka phepo e sa lekanyetsoang kapa e sa lekaneng, hammoho le lijo tse haelloang ke lik'habohaedreite.
Hypoglycemia hangata e hlaha ka ho ja lijo tse nang le khalori e tlase, kamora ho ikoetlisa nako e telele kapa e matla, ka mor'a ho sebelisa lithethefatsi tse nang le ethanol kapa ethanol, kapa ha u sebelisa lithethefatsi tse 'maloa tsa hypoglycemic ka nako e le' ngoe.
Ka tloaelo, matšoao a hypoglycemia a nyamela kamora ho ja lijo tse nang le lik'habohaedreite tse ngata (tse kang tsoekere). Re lokela ho hopola hore ho nka li-sweeteners ha ho thusa ho tlosa matšoao a hypoglycemic. Phihlelo ea ho sebelisa litlatsetso tse ling tsa sulfonylurea e fana ka maikutlo a hore hypoglycemia e ka khutla le ha boemo bona bo ka ba bonolo. Maemong matšoao a hypoglycemic a boletsoe kapa a nka nako e telele, le maemong a ntlafatso ea nakoana kamora ho ja lijo tse nang le lik'habohaedreite, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka, ho fihlela sepetlele.
Bakeng sa ho qoba kholo ea hypoglycemia, ho hlokahala hore motho a khethe lithethefatsi le mofuta oa kalafo ka hloko hammoho le ho fa mokuli tlhaiso-leseling e felletseng ka kalafo.
Kotsi e eketsehileng ea hypoglycemia e ka hlaha maemong a latelang:

• ho hana kapa ho se khonehe ha mokuli (haholo-holo batho ba baholo) ho latela litaelo tsa ngaka le ho hlokomela boemo ba hae,
• phepo e sa lekaneng le e sa sebetseng, ho tlōla lijo, ho itima lijo le ho fetola lijo,
• ho se lekane pakeng tsa ts'ebetso ea 'mele le palo ea lik'habohaedreite tse nkiloeng,
• ho hloleha ha rems
• ho hloleha ho matla ha sebete
• overdose of the drug Bareken ® MV,
• mathata a mang a endocrine: lefu la qoqotho, ho hloleha ha sethoathoa le ho hlaka,
• tšebeliso e tšoanang ea lithethefatsi tse ling (bona karolo "Ho sebelisana le lithethefatsi tse ling"). Lipontšo tsa kliniki tsa hypoglycemia li ka koaloa ha ho nkuoa li-beta-blockers, clonidine, reserpine, guanethidine.

Ho hloleha ha letsoalo le sebete
Ho bakuli ba nang le hepatic le / kapa ho se sebetse hantle haholo ka mpeng, pharmacokinetic le / kapa li-pharmacodynamic thepa ea gliclazide e ka fetoha.
Boemo ba hypoglycemia bo hlahang ho bakuli ba joalo bo ka ba telele haholo, maemong a joalo, ho hlokahala kalafo e loketseng hanghang.

Tlhahisoleseling ea mokuli
Hoa hlokahala ho tsebisa mokuli, hammoho le litho tsa lelapa la hae, ka kotsi ea ho ba le hypoglycemia, matšoao a eona le maemo a tsamaisanang le kholo ea eona. Mokuli o tlameha ho tsebisoa ka likotsi le melemo ea kalafo e boletsoeng.
Mokuli o hloka ho hlakisa bohlokoa ba ho ja, tlhoko ea ho ikoetlisa khafetsa le ho lekola likhahla tsa tsoekere ea mali.
Taolo ea tsoekere e sa lekaneng ea mali
Taolo ea glycemic ho bakuli ba fumanang kalafo ea hypoglycemic e ka fokola maemong a latelang: ts'ebetso e kholo ea ts'ebetso ea ho buoa le ho lemala, ho chesa haholo, mafu a tšoaetsanoang a nang le febrile syndrome. Ka maemo ana, ho ka 'na ha hlokahala hore u khaotse ho phekoloa ka moriana oa Diabeteson ® MV le ho fana ka kalafo ea insulin.
Ho bakuli ba bang, katleho ea li-antic hypoglycemic agents, ho kenyelletsa le gliclazide, e fokotseha ka mor'a nako e telele ea kalafo. Tšusumetso ena e ka bakoa ke ho tsoela pele ha lefu lena le ho fokotseha ha karabelo ea kalafo ho moriana. Phello ena e tsejoa e le ho hanyetsa lithethefatsi tsa bobeli, tse lokelang ho khetholloa ho ea mantlha, moo moriana o sa feng phello e lebelletsoeng ea kliniki e seng e le teng ka nako ea pele. Pele o tseba mokuli ka khatello ea bobeli ea lithethefatsi, ho hlokahala hore ho hlahlojoe ho lekana ha khetho ea lethal dose le ho lumellana le mokuli ka lijo tse boletsoeng.

Liteko tsa Lab
Ho hlahloba taolo ea glycemic, ho khothaletsoa boikemisetso ba ho itima lijo ba glucose le khatello ea "hemoglobin" ea HbA1c hangata. Ntle le moo, ho bohlokoa hore nako le nako u itlhahlobe ho tsepamisang mahlo tsoekere ea mali.
Lintho tse tsoang ho Sulfonylurea li ka baka anemia ea hemolytic ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase. Kaha gliclazide ke sulfonylurea e tsoang ho eona, tlhokomelo e lokela ho nkuoa ha e e fuoa ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase.
Monyetla oa ho hlahisa moriana oa hypoglycemic oa sehlopha se seng o lokela ho hlahlojoa.

HO SIRELETSA MOKHATLO OA HO FIHLA KOLOI LE HO ETSA MOSA OA HO BUA HO BUA KOTSI E HAHOLO
Bakuli ba lokela ho hlokomela matšoao a hypoglycemia mme ba lokela ho ba hlokolosi ha ba khanna kapa ba etsa mosebetsi o hlokang sekhahla se phahameng sa maikutlo le kelello, haholo qalong ea kalafo.

TLHOKOMELISO MOTSAMAI
Matlapa a lokolotsoeng a 30 mg
Matlapa a 30 ka blister e ngoe le e ngoe (PVC / Al), maleiri a le 1 kapa a mabeli a nang le litaelo tsa tšebeliso ea bongaka ka lebokoseng la karete.
Ha ho paka (ho paka) k'hamphaning ea Marang-rang ea Sensource ea Russia: Matlapa a 30 ka blister e ngoe le e ngoe (PVC / Al), mabili a mabeli a nang le litaelo tsa ho sebelisoa ka lebokoseng la karete.

MAHLOMPHO MOTS'ELISO
Ho hlokahala maemo a khethehileng a polokelo.
Qoba hole le bana.
Lenane B.

BOPHELO SHELF
Lilemo tse 3 Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

TS'ELISO MAHALA
Ka lengolo la ngaka.

Setifikeiti sa ho ingolisa se fanoeng ke bahlanka ba Laborata, Fora

E hlahisitsoe ke Servier Industry Lab, France
"Indasteri ea Basebeletsi ba Laborator":
905, tsela e kholo ea Saran, 45520 Gidey, Fora
905, tsela de Saran, 45520 Gidy, France

Bakeng sa lipotso tsohle, ikopanye le Ofisi ea Moemeli oa JSC "Worker's Laborator".

Phatlalatso ea "Mosebeletsi oa Laborator":
115054, Moscow, Paveletskaya pl. d.2, leq. 3

Serdix LLC:
142150, Russia, Setereke sa Moscow,
Setereke sa Podolsky, motsana oa Sof'ino, leq. 1/1

Setifikeiti sa ho ingolisa se fanoeng ke bahlanka ba Laborata, Fora
E hlahisitsoe ke: Serdix LLC, Russia
Serdix LLC:
142150, Russia, Setereke sa Moscow,
Setereke sa Podolsky, motsana oa Sof'ino, leq. 1/1
Bakeng sa lipotso tsohle, ikopanye le Ofisi ea Moemeli oa JSC "Worker's Laborator".

Phatlalatso ea "Mosebeletsi oa Laborator":
115054, Moscow, Paveletskaya pl. d.2, leq. 3