Na li-statins li baka lefu la tsoekere la 2?

Statins, eo hangata e laeloang ho theola cholesterol e tlase, e eketsa kotsi ea lefu la tsoekere la 2 ka 30%. Liphetho tsa liteko tsa morao-rao li hlahisitse moelelo oa lipuisano lefatšeng la bongaka i.

Statins ke e 'ngoe ea lithethefatsi tse laetsoeng haholo ho la USA. Khale ka 2012, hoo e ka bang kotara ea baahi ba US ba fetang 40 ba hlile ba sebelisa lithethefatsi tse theolelang k'holeseterole, maemong a mangata - li-statins. Kajeno, palo ena e nyolohetse ho 28% (le ha ba ngolisitsoe palo e kholo haholo ea MaAmerika).

Statins e fokotsa cholesterol ea mali ka ho theola tlhahiso ea eona ke sebete. Ba thibela enzyme hydroxymethylglutaryl-coenzyme A-reductase ho eona, e amehang tlhahisong ea k'holeseterole.

Ntle le moo, li-statins li boetse li fokotsa khatello ea maikutlo le khatello ea maikutlo. Ha ho fanoa ka litlamorao tsena kaofela, motho a ka lebella hore li-statins li fokotse kotsi ea lefu la tsoekere la mofuta oa 2.

Leha ho le joalo, bopaki bo tsoang palo e ntseng e eketseha ea lithuto bo bontša ho fapana - tšebeliso ea nako e telele ea li-statins e eketsa kotsi ea lefu la tsoekere la mofuta oa 2. Boithuto ba pele joalo bo phatlalalitsoe morao ka selemo sa 2008. ii.

Ha ke e araba, lithuto tse 'maloa li ile tsa etsoa haufinyane,' me e 'ngoe ea tsona (ka 2009) ea re, ho latela mokhoa oa bona, ho ne ho se na litlamorao tse sa sebetseng tsa tšebeliso ea li-statin kotsing ea lefu la lefu la tsoekere mme ka hona lithuto tse ling li ne li hlokahala iii, le ba bang (ka selemo sa 2010 ) - - hore ho na le sebaka sa ho eketsa kotsi ea lefu la tsoekere, empa e le sa bohlokoa bo boholo iv (ho se lumellane ho joalo lithutong ho ka hlalosoa ke hore lithuto tse ling li tšehelitsoe ke likhamphani tsa meriana le tsona - Mofetoleli oa Mofetoleli).

Ho fumana boemo ba 'nete, bafuputsi ba koleche ea Albert Einstein of Medicine e New York ba ile ba etsa qeto ea ho atamela taba ena ka tsela e fapaneng' me ba tsepamisa maikutlo ho batho ba feteletseng 'me ka lebaka leo, ba na le monyetla oa ho ba le lefu la tsoekere la mofuta oa 2. Sehlopha sa bo-rasaense se sebelisitse data ea semmuso ho tsoa Lenaneong la Thibelo ea Lefu la Ts'oaetso la United States (DPPOS). Ka kakaretso, ts'ebeliso ea li-statins e lebisitse keketseho ea 36% kotsing ea lefu la tsoekere la mofuta oa 2. Lebaka feela le etsang hore ho be le lipelaelo ka lipalo tse kholo joalo tsa kholo ea kotsi ke hore li-statins li ne li laetsoe ho latela tlhahlobo ea mokuli ke ngaka, ka hona barupeluoa ha baa ka ba ajoa ka boomo. Liphetho li phatlalalitsoe ho patlisiso ea lefu la tsoekere ea BMJ le tlhokomelo v.

Sehlopha se sa tsoa boleloa sa bo-ramahlale se khothalelitse ka matla hore bakuli ba kotsing e kholo ba behiloeng li-statins bakeng sa ho thibela mafu a pelo le bona ba lekole maemo a bona a tsoekere ka mehla le ho phela bophelo bo phetseng hantle.

Tlas'a tšusumetso ea data e joalo, ka 2012, US Food and Drug Administration e ile ea fana ka temoso mabapi le kotsi e ka 'nang ea eketseha ea lefu la tsoekere ho bakuli ba nkang lithethefatsi tse theolang cholesterol le taolo e thata ea glycemic ho ba seng ba na le lefu la tsoekere vi.

Ka lebaka la hore li-statins li laetsoe haholo USA mme li hlile li fokotsa kotsi ea mathata a tebileng a pelo, puisano mabapi le lefu la tsoekere e hlahisang lefu la tsoekere ha e so fele.

Leha ho le joalo, haufinyane tjena, palo ea lithuto tse tšehetsang khopolo ena e ntse e eketseha joaloka sekhahla:

• "Tšebeliso ea li-statins le kotsi ea ho ba le lefu la tsoekere," Barty Chogtu le Rahul Bairy, Koranta ea Lefatše ea lefu la tsoekere, 2015 vii,
• "Statins le kotsi ea ho ba le lefu la tsoekere," Goodarz Danaei, A. Luis Garcia Rodriguez, Cantero Oscar Fernandez, Miguel Hernan A., Tlhokomelo ea Lefu la Tsoekere ea American Diabetes Association 2013 viii,
• "Ho Sebelisa Statin le Kotsi ea Lefu la Ts'oaetso," Jill R Crandell, Kiren Maser, Swapnil Rajpasak, RB Goldberg, Carol Watson, Sandra Foo, Robert Ratner, Elizabeth Barrett-Connor, Temproza ​​Marinella, BMJ Open Diabetes research and Care, 2017 ix,
• "Rosuvastatin bakeng sa thibelo ea liketsahalo tsa methapo ho banna le basali ba nang le protheine e phahameng ea C," Paul M. Ridker, Eleanor Danielson, Francisco HA Fonseca, Jacques Genest, Antonio M. Gotto, John JP Castelein, Wolfgang Cohenig, Peter Libby, Alberto J Lorenzatti, Jean G. MacPheiden, Borg G. Nordeard, James Shepherd, The New England Journal of Medicine, 2008 x,
• "Ts'ebeliso ea li-statins e eketsa kotsi ea lefu la tsoekere la mofuta oa 2," Jack Woodfield, Diabetes.co.uk, 2017 xi
• "Lefu la tsoekere la Statin le bakiloe ke litlamorao tsa lona tsa kalafo", Umme Ayman, Ahmad Najmi le Rahat Ali Khan, Journal of Pharmacology and Pharmacotherapeutics, 2014 xii.

Sengoloa sa ho qetela sea khahla haholo. O fana ka datha hore menyetla ea lefu la tsoekere e tlas'a tšusumetso ea li-statins e tloha ho 7% ho isa ho 32%, ho latela mofuta oa statin, lethal dose le lilemo tsa mokuli. Bo-rasaense ba fumane hore hangata li-statin li baka tsoekere 'me li mpefatsa boemo ba tsona. Sengoloa se boetse se fana ka mokhoa o ka hlahisang lefu la tsoekere la mofuta oa 2:

semelo sa eona se ikhutsetsang hanyane ka hofihlela taba ea hore, ntle le ho fokotsa tlhahiso ea k'holeseterole ke sebete, li-statins li boetse li fokotsa tlhahiso ea insulin le ho ts'oaroa ke insulin liseleng, tseo le tsona li bakang ho fokotseha ha molumo oa mesifa le matla a ho ikoetlisa.

Lingoloa tse ling tse ngata tsa mahlale li tiisa hore ts'ebeliso ea li-statins e na le bofokoli ba mesifa le bohloko ho bona ka lebaka la khaello ea k'holeseterole:

• "Kamano lipakeng tsa Statins and Exercises ...", Richard E. Deichmann, Carl Jay Lavi, Timothy Asher, James D. Dinicolantonio, James H. O'Keefe le Paul D. Thompson, Koranta ea Ochsner, 2015 xiii,
• "Litlamorao tsa mesifa ea mesifa ea marapo: boikoetliso, myopathy le matla a mesifa," Beth Parker, Paul Thompson, Tlhahlobo ea Boikoetliso le Lipapali tsa Saense ea Lipapali, 2012 xiv,
• "Ho ikoetlisa ho fokola hoa lithethefatsi tsa statin?", Ed Fiz, New York Times, 2017 xv.

Ntle le moo, lingoliloeng li hlaha khafetsa hore li-statins li hlile li eketsa menyetla ea ho hlaha ha lefu la Parkinson le nts'etsopele, ho fapana le liqoso tsa pele ho xvi xvii xviii xix.

Ke mang ea hlokang li-statins?

Ka lebaka la 'mele o ntseng o hola oa bopaki ba mahlale mabapi le litlamorao tse mpe tsa li-statin, lingoliloeng tse ling tsa bongaka li botsa lingaka le bakuli ho ipotsa hore na melemo ea ho sebelisa li-statins e feta litla-morao tsa bona tse mpe kapa che.

Kahoo, mohlala, haeba mokuli a e-na le pelo e kulang e nang le sekhahla sa "cholesterol" maling, a kanna a hloka ho nka li-statin, hobane ho seng joalo a ka shoa neng kapa neng. Ntle le moo, ho lokela ho hopoloa hore lefu la tsoekere ha le na ho hlaha ho eena ka monyetla oa 100%. Haeba k'holeseterole ea mokuli e sa phahama haholo mme boemo ba pelo ba mokuli bo sa khotsofala kapa ho sa khotsofale, mohlomong o lokela ho ja le ho ikoetlisa. Leha ho le joalo, le ntlheng ena, ho hana ho nka li-statins ho lokela ho nahanoa ka ho buisana le ngaka mme ho etsoa ka mekhahlelo le ka hloko. Haholo-holo, sengoloa se reng "Litla-morao tsa statin: lekanya melemo le likotsi tsa" basebetsi ba Mayo Clinic xx li batla mokhoa ona.

Lingoliloeng tse ling, joalo ka, mohlala, Aspirin vs. Statins, li bona tsela ea ho tlosa li-statin le aspirin bakeng sa bakuli ba seng boima. Ho fapana le li-statin, aspirin ha e theole cholesterol ea mali, empa e tsitsisa mali, e thibela likarolo tsa cholesterol hore li se ke tsa khomarela mali. Le ha litsebi tse ling li tšehetsa pono ena, ba bang ba lumela hore aspirin e ke ke ea nka sebaka se phethahetseng sa li-xxi statins.