Metfogamm® 850 (Metfogamma® 850)

Letlapa le leng le na le:

Lintho tse sebetsang: metformin hydrochloride - 850 mg.

Baeti: hypromellose, povidone, stearate ea magnesium.

Sebopeho sa Shell: hypromellose, macrogol 6000, titanium dioxide (E 171).

Matlapa a tšoeu a bosoeu, a kopantsoeng le filimi, a nang le mola o nang le liphoso ka mahlakoreng ka bobeli, a batlang a le thata.

Ketso ea pharmacological

Metphogamma 850 ke setlhare sa molomo sa hypoglycemic se tsoang sehlopheng sa Biguanide. E thibela gluconeogeneis ka har'a sebete, e fokotsa ho monya ha tsoekere ka mpeng, e ntlafatsa ts'ebeliso ea tsoekere, hape e eketsa kutloisiso ea lisele tsa mmele ho insulin. Leha ho le joalo, ha e ame sephiri sa insulin ke lisele tsa beta tsa manyeme. Fokotsa boemo ba triglycerides le lipoprotein tse tlaase maling. E tsitsisa kapa e theola boima ba 'mele. E na le phello ea fibrinolytic ka lebaka la khatello ea inhibitor ea tisy ea plasminogen activator.

Mofumahali

Kamora ho tsamaisoa ka molomo, moriana o ananeloa ho tsoa mokokotlong oa mpa. Bioavailability kamora ho nka tekanyetso e tloaelehileng ke -50-60%. Palo e phahameng ea plasma ea mali e fihlella lihora tse peli ka mor'a ho kenella. Ha e lumellane le liprotheine tsa plasma. E bokellana ka har'a litsoelesa tse tsoang ka mothong, sebete le liphio. E hloekisoa e sa fetoloe ke liphio. Bophelo ba halofo ke lihora tse 1.5-4,5.

Ka ts'ebetso ea renal e sa sebetseng hantle, ho sebelisoa hoa lithethefatsi hoa khoneha.

Tekanyetso le tsamaiso

Tekanyo ea Metfogamm 850 e behiloe ka mokhoa o le mong, ho nahanela boemo ba tsoekere maling. Tekanyetso ea pele hangata hangata ke 850 mg (pilisi e le 'ngoe) ka letsatsi, keketseho e tsoelang pele ea butle-butle ea litekanyetso e ka khona ho latela phello ea kalafo. Tekanyo ea tlhokomelo ea lithethefatsi ke 850-1700 mg (matlapa a 1-2) ka letsatsi. Tekanyetso e kholo ea letsatsi le letsatsi ke 1700 mg (matlapa a mabeli), ho beoa ha litekanyetso tse phahameng ha ho eke phello ea kalafo.

Tekanyetso ea letsatsi le letsatsi e fetang 850 mg e khothaletsoa ho tekanyetso tse peli (hoseng le mantsiboea). Bakeng sa bakuli ba tsofetseng, tekanyetso ea letsatsi le letsatsi e khothalletsoang ha ea lokela ho feta 850 mg.

Matlapa a Metphogamm 850 a lokela ho nooa le lijo, a felletse, a hlatsoitsoe ka metsi a fokolang (khalase ea metsi). Tsela ea kalafo ka moriana e telele.

Litla-morao

Ho tsoa pampitšana ea ka mpeng: ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, lets'ollo, ho hloka takatso ea lijo, tatso ea "tšepe" molomong. Maemong ana, ho khaotsa kalafo hangata ha ho hlokehe, 'me matšoao a rarolla a le mong ntle le ho fetola tekanyetso. Khafetsa le ho teba ha litla-morao tse tsoang mpeng ea mpa li ka fokotseha ka keketseho ea butle-butle ea lethal dose ea metformin.

Litla-morao:

Ho tsoa tsamaisong ea endocrine: hypoglycemia (haholo ha e sebelisoa ka tekanyetso e sa lekanang).

Metabolism: maemong a sa tloaelehang, lactic acidosis (e hloka ho felisoa ha kalafo).

Ho tsoa ho sistimi ea hemopoietic: maemong a mang - anemia ea megaloblastic.

Bongata

Ka overdose ea Metfogamma 850, lactic acidosis e nang le sephetho se bolaeang e ka etsahala. Sesosa sa nts'etsopele ea lactic acidosis le eona e ka ba ho lutla ha moriana ka lebaka la ts'ebetso ea renal e sa sebetseng. Matšoao a pele a lactic acidosis ke ho nyekeloa pelo, ho hlatsa, lets'ollo, feberu, bohloko ba ka mpeng, bohloko ba mesifa, joale ho kanna ha eketsoa ho hema, ho tsekela, ho akheha kelellong le ho holofala ha lets'oaetso. sepetlele mokuli ka potlako mme, ha a se a lemohile hore na ke lactate e kae, netefatsa lefu lena. Mohato o sebetsang ka ho fetisisa oa ho tlosa lactate le Metphogamm 850 'meleng ke hemodialysis. Phekolo ea matšoao le eona ea etsoa. Ka kalafo e kopaneng ea Metphogamm 850 ka litokisetso tsa sulfonylurea, hypoglycemia e ka hlaha.

Ho sebelisana le lithethefatsi tse ling

Ka tšebeliso e le 'ngoe le metsoako ea sulfonylurea, acarbose, insulin, lithethefatsi tse seng khahlanong le' mele tse thibelang mafu, li-inhibitors tsa MAO, oxytetracycline, li-inhibitors tsa ACE, li-derifatives tsa cyofophrate, cyclophosphamide, B-blockers, ho khonahala ho eketsa phello ea hypoglycemic ea metformin. Ka ts'ebeliso e ts'oanang le glucocorticosteroids, lithibela-pelehi tsa molomo, epinephrine, sympathomimetics, glucagon, lihormone tsa qoqotho, thiazide le "loop" diuretics, melemo ea phenothiazine, li-nicotinic acid tse tsoang teng, ho ka etsahala ho fokotsa phello ea hypoglycemic ea metformin.

Cimetidine e liehisa ho felisoa ha metformin, e eketsang kotsi ea lactic acidosis.

Metformin e ka fokolisa phello ea li-anticoagulants (tse tsoang ho coumarin). Ka tšebeliso e ngata ea joala ka nako e tšoanang, lactic acidosis e ka hlaha.

Likarolo tsa ts'ebeliso

Ha e khothalletsoe tšoaetso e matla, ho mpefatsa ha mafu a tšoaetsanoang a sa foleng le ho ruruha, likotsi, maloetse a opang ka matla, ha ho bontšoa kalafo ea insulin. Se ke oa sebelisa pele u buuoa le pele ho feta matsatsi a mabeli kamora hore a buuoe.

Ts'ebeliso ea Metfogamm 850 ha e khothaletsoe bonyane matsatsi a 2 pele le matsatsi a 2 kamora x-ray kapa tlhatlhobo ea radiology o sebelisa liakhente tse fapaneng. Ha ho kgothaletswe ho sebelisa lithethefatsi ho bakuli phepelong e nang le lithibelo ho kenella ka caloric (

Tlhophiso ea Nosological (ICD-10)

Mofumahali

E thibela gluconeogeneis ka har'a sebete, e fokotsa ho monya ha tsoekere ka mpeng, e ntlafatsa ts'ebeliso ea tsoekere, 'me e phahamisa kutloisiso ea lisele tsa mmele ho insulin. Fokotsa boemo ba triglycerides le lipoprotein tse tlaase maling. E na le phello ea fibrinolytic (e thibela ts'ebetso ea mofuta oa li-inhibitor tsa mofuta oa lisele), e tsitsisa kapa e theola boima ba 'mele.

Contraindication

lefu la tsoekere la ketoacidosis, lefu la tsoekere le leta,

Ho lemala hampe ha renal le hepatic,

pelo le ho hloleha ho phefumoloha,

karolo e mpe ea infarction ea myocardial,

kotsi e mpe ea methapo ea pelo

lactic acidosis le lipontšo tsa eona historing, maemo a ka kenyang letsoho ho nts'etsopele ea lactic acidosis, ho kenyelletsa joala bo sa foleng,

Litlamorao

Ho tsoa ho tsamaiso ea pelo le mali (hematopoiesis, heestasis): maemong a mang me anemblastic anemia.

Ho tsoa ho tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, lets'ollo, ho hloka takatso ea lijo, tatso ea tšepe e ka hanong.

Ka lehlakoreng la metabolism: hypoglycemia, maemong a sa tloaelehang, lactic acidosis (e hloka kalafo).

Litla-morao: lekhopho la letlalo.

Litaelo tse khethehileng

Ha e khothalletsoe mafu a tšoaetsanoang a tšoaetsanoang kapa ho ata ha maloetse a sa foleng le a sa foleng, likotsi, maloetse a bohloko a pelehi, pele ho ts'oaetso le matsatsing a 2 kamora hore a etsoe opereishene, le matsatsing a 2 pele le kamora liteko tsa tlhahlobo (radiological and radiological) ts'ebeliso ea mecha ea litaba e bapisoang). Ha ea lokela ho sebelisoa ho bakuli phepelong e nang le litekanyetso tsa ho kenella ka caloric (ka tlase ho 1000 kcal / ka letsatsi). Ts'ebeliso ea lithethefatsi ha e khothalletsoe ho batho ba lilemo tse fetang 60 ba etsang mosebetsi o boima oa 'mele (ka lebaka la kotsi e eketsang ea ho holisa lactic acidosis).

Tšusumetso ho bokhoni ba ho khanna makoloi le ho sebetsa ka mekhoa. Ha ho na phello (ha e sebelisoa e le monotherapy). Hammoho le li-agents tse ling tsa hypoglycemic (sulfonylurea derivatives, insulin, joalo-joalo), nts'etsopele ea linaha tsa hypoglycemic e khonahala, moo bokhoni ba ho khanna makoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang tlhokomelo e potlakileng le lebelo la karabelo ea psychomotor li senyehile.

Moetsi

Werwag Pharma GmbH & Co KG, Kalverstrasse 7, 71034, Beblingen, Jeremane.

Moetsi: Artesan Pharma GmbH & Co KG, Wendlandstrasse, 1, 29439, Lyukhov, Jeremane.

Dragenopharm Apotheker Püschl GmbH & Co KG, Gellstrasse, 1, 84529, Tittmoning, Jeremane.

CJSC ZiO-Zdorovye, Russia, 142103, Setereke sa Moscow, Podolsk, ul. Terene, 2.

Ofisi ea moemeli / mokhatlo o amohelang likopo: Ofisi ea moemeli oa k'hamphani Vervag Pharma GmbH & Co CG in the Russian Federation.

117587, Moscow, tsela e kholo ea Warsaw, 125 F, bldg. 6.

Mohala: (495) 382-85-56.

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi, 850 mg

Letlapa le leng le na le

ntho e sebetsang - metformin hydrochloride 850 mg

(e lekanang le metformin 662.8 mg),

excipients: hypromellose (15000 mPas), Povidone K25, magnesium stearate,

sebopeho sa sheath: hypromellose (5mPas), macrogol 6000, titanium dioxide (E171).

Matlapa a bopehileng a nang le biconvex holimo, a koaheletsoeng ka koae e tšoeu ea filimi, a nang le kotsi ka mahlakoreng ka bobeli, bophara (7.5 ± 0.5 x 21.5 ± 0.5) mm le bolelele (6.0 ± 6.8) mm.

Melemo ea pharmacological

Kamora ho tsamaisoa ka molomo, metformin e nkuoa ho tsoa mokokotlong oa mpa. Bioavailability kamora ho nka tekanyetso e tloaelehileng ke 50-60%. Cmax e phahameng ka ho fetisisa ea plasma e fihlella lihora tse 2,5 ka mor'a ho kenella. Ha e lumellane le liprotheine tsa plasma. E bokellana ka har'a litsoelesa tse qhekellang, mesifa, sebete le liphio. Metformin e tsamaisoa ka lisele tse khubelu tsa mali; lisele tse khubelu tsa mali mohlomong ke depo ea bobeli ea phepelo. E hloekisoa e sa fetoloe ke liphio. Bophelo ba halofo ke lihora tse 6.5. Haeba ho sebetsoa ka mokhoa o sa sebetseng oa renal, ho fumaneha ha moriana hoa khoneha. Ho nahanoa hore li-pharmacokinetics tsa metformin adsorption ha li tsamaee.

Metfogamm ® 850 inhibits gluconeogenesis bokong, e fokotsa ho monya ha tsoekere maling, e ntlafatsa ts'ebeliso ea glucose, hape e eketsa kutloisiso ea lithane ho insulin. Metformin e phahamisa motsoako oa glycogen o kenang ka ho sebetsa ka glycogen synthase, e eketsa palo ea lipalangoang ea mefuta eohle ea li-protein tsa membrane glucose. Leha ho le joalo, ha e ame sephiri sa insulin ke lisele tsa beta tsa manyeme. Lowers cholesterol e felletseng, triglycerides le lipoprotein tse tlaase maling. E tsitsisa kapa e theola boima ba 'mele. E na le phello ea fibrinolytic ka lebaka la khatello ea inhibitor ea tisy ea plasminogen activator.

Fomati ea ho lokolla, ho paka le ho hlophisa Metfogamma ® 850

Matlapa, a koahetsoeng ka koae e tšoeu ea filimi, a pepetehile, a na le kotsi, a se na monko.

Bahlomphehi: hypromellose (1500CPS), hypromellose (5CPS), povidone (K25), magnesium stearate, macrogol 6000, titanium dioxide.

Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (12) - lipakete tsa karete.
20 likhomphutha. - lithutsoana (6) - lipakete tsa karete.

Melemo ea litekanyetso

Beha ka bomong, o ela hloko boemo ba glucose maling.

Tekanyetso ea pele ke hangata 850 mg (1 tab.) / Letsatsi. Keketseho e ntseng e eketseha butle-butle ea tekanyetso e ka khonahala ho latela phello ea kalafo. Tekanyetso ea tlhokomelo ke 850-1700 mg (matlapa a 1-2) / letsatsi. Sekhahla se phahameng sa letsatsi ke 2550 mg (matlapa a 3).

Tekanyetso ea letsatsi le letsatsi e fetang 850 mg e khothaletsoa ho tekanyetso tse peli tse arohaneng (hoseng le mantsiboea).

Bakeng sa bakuli ba tsofetseng, tekanyo e khothalletsoang ha ea lokela ho feta 850 mg / ka letsatsi.

Matlapa a lokela ho nooa le lijo ka kakaretso, a hlatsoe ka metsi a fokolang (khalase ea metsi).

Setlhare sena se reretsoe tšebeliso ea nako e telele.

Ka lebaka la kotsi e eketsehang ea lactic acidosis, mathateng a tebileng a metabolic, lethal dose e lokela ho fokotsoa.

Ho sebelisana le lithethefatsi

Ka ts'ebeliso e le 'ngoe le sulfonylurea derivatives, acarbose, insulin, NSAIDs, li-inhibitors tsa MAO, oxetetracycline, li-inhibitors tsa ACE, li-derifatives tse tsoang ka har'a marang-rang, cyclophosphamide le beta-blockers, ho khonahala ho eketsa phello ea hypoglycemic ea metformin.

Ka ts'ebeliso e le 'ngoe le GCS, lithibela-pelehi tsa molomo, epinephrine (adrenaline), sympathomimetics, glucagon, lihomone tsa qoqotho, thiazide le loopback diuretics, li-phenothiazine derivatives le nicotinic acid, ho fokotseha hoa phello ea hypoglycemic ea metformin ho ka etsahala.

Cimetidine e liehisa ho felisoa ha metformin, ka lebaka leo kotsi ea lactic acidosis e eketsehang.

Metformin e ka fokolisa phello ea li-anticoagulants (tse tsoang ho coumarin).

Ka tsamaiso e ts'oanang ka ethanol, nts'etsopele ea lactic acidosis e khonahala.

Ka tšebeliso e tšoanang ea nifedipine e eketsa ho amoheloa ha metformin, C max, e liehisa ho tebela.

Lithethefatsi tsa cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) tse fumanehang ka har'a marang-rang li qothisana le litsamaiso tsa tsamaiso ea lefutso, 'me ka kalafo ea nako e telele li ka eketsa C max metformin ka 60%.

Matšoao a ho sebelisoa

- kalafo ea mofuta oa lefu la tsoekere la mofuta oa 2 ho batho ba baholo, haholo ho bakuli ba boima bo feteletseng, haeba ho ja le ho ikoetlisa ho sa fane ka taolo e lekaneng ea glycemic,

e le monotherapy kapa hammoho le li-antidiabetesic tse ling tsa molomo, kapa ka insulin

Ho sebelisana le lithethefatsi

Motsoako o sa khothalletsoang.

Ho itlopa joala haholo ho eketsa kotsi ea ho lactic acidosis, haholo maemong a latelang:

- tlala kapa khaello ea phepo e nepahetseng,

Hoa hlokahala ho qoba tšebeliso ea lino tse tahang le tse nang le lino tse tahang kalafo ea metformin.

Manonyeletso a nang le iodine

Tšebeliso ea methapo ea methapo e nang le iodine e tsamaeang ka har'a methapo e ka lebisa ho ho hloleha ha liphio, ho lebisang ho bokelleng ha metformin, le kotsi e kholo ea lactic acidosis. Ts'ebeliso ea metformin e lokela ho emisoa pele ho ts'ebeliso ea basebelisi ba phapang e joalo, nakong ea lithuto ka ts'ebeliso ea bona le nakong ea lihora tse 48 kamora hore ba phethe. Phekolo e lokela ho tsoelapele ka lihora tse 48 kamora ho qeta thuto le kamora feela hore ho etsoe tlhahlobo ea bobeli ea ts'ebetso ea liphio ebe ho fumanoa sephetho se tloaelehileng.

Motsoako o hlokang mehato e khethehileng ea ho ba hlokolosi ha o sebelisa

M meriana ka ts'ebetso ea eona ea tlhaho ea hyperglycemic, ka mohlala, li-glucocorticoids (bakeng sa ts'ebeliso ea kemiso le ea lehae), li-agonists tsa beta-2, sympathomimetics.

Bakuli ba lokela ho tsebisoa ka sena, ba khothaletsa hore ba hlahlobe likhahla tsa tsoekere ea mali hangata, haholo-holo ha ba qala kalafo. Haeba ho hlokahala, litekanyetso tsa metformin nakong ea kalafo li lokela ho laoloa, haholo ha o sebelisa lithethefatsi tse ling le kamora ho khaotsa ho li sebelisa.

Diuretics, haholo-holo loop diuretics.

Kaha ho na le kotsi ea ho fokotsa ts'ebetso ea renal, ho na le kotsi e kholo ea ho nts'etsapele lactic acidosis.

Li-inhibitors tsa ACE li ka baka ho fokotseha hoa maemo a tsoekere ea mali. Haeba ho hlokahala, litekanyetso tsa moriana oa hypoglycemic li lokela ho fetoloa nakong ea kalafo u sebelisa li-inhibitors tsa ACE le kamora ho khaotsa kalafo ena.